-- dump date 20140619_150120 -- class Genbank::misc_feature -- table misc_feature_note -- id note 648999000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 648999000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999000003 Walker A motif; other site 648999000004 ATP binding site [chemical binding]; other site 648999000005 Walker B motif; other site 648999000006 arginine finger; other site 648999000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 648999000008 DnaA box-binding interface [nucleotide binding]; other site 648999000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 648999000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 648999000011 putative DNA binding surface [nucleotide binding]; other site 648999000012 dimer interface [polypeptide binding]; other site 648999000013 beta-clamp/clamp loader binding surface; other site 648999000014 beta-clamp/translesion DNA polymerase binding surface; other site 648999000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 648999000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 648999000017 recombination protein F; Reviewed; Region: recF; PRK00064 648999000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 648999000019 Walker A/P-loop; other site 648999000020 ATP binding site [chemical binding]; other site 648999000021 Q-loop/lid; other site 648999000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999000023 ABC transporter signature motif; other site 648999000024 Walker B; other site 648999000025 D-loop; other site 648999000026 H-loop/switch region; other site 648999000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 648999000028 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999000029 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000030 putative DNA binding site [nucleotide binding]; other site 648999000031 putative Zn2+ binding site [ion binding]; other site 648999000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 648999000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999000034 Mg2+ binding site [ion binding]; other site 648999000035 G-X-G motif; other site 648999000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 648999000037 anchoring element; other site 648999000038 dimer interface [polypeptide binding]; other site 648999000039 ATP binding site [chemical binding]; other site 648999000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 648999000041 active site 648999000042 putative metal-binding site [ion binding]; other site 648999000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 648999000044 DNA gyrase subunit A; Validated; Region: PRK05560 648999000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 648999000046 CAP-like domain; other site 648999000047 active site 648999000048 primary dimer interface [polypeptide binding]; other site 648999000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 648999000056 EamA-like transporter family; Region: EamA; pfam00892 648999000057 Predicted ATPase [General function prediction only]; Region: COG3911 648999000058 AAA domain; Region: AAA_28; pfam13521 648999000059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000060 putative DNA binding site [nucleotide binding]; other site 648999000061 dimerization interface [polypeptide binding]; other site 648999000062 putative Zn2+ binding site [ion binding]; other site 648999000063 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000064 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 648999000065 Dienelactone hydrolase family; Region: DLH; pfam01738 648999000066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000067 dimerization interface [polypeptide binding]; other site 648999000068 putative DNA binding site [nucleotide binding]; other site 648999000069 putative Zn2+ binding site [ion binding]; other site 648999000070 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 648999000071 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 648999000072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 648999000073 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 648999000074 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 648999000075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999000076 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 648999000077 Soluble P-type ATPase [General function prediction only]; Region: COG4087 648999000078 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 648999000079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999000080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999000081 NADH(P)-binding; Region: NAD_binding_10; pfam13460 648999000082 NAD(P) binding site [chemical binding]; other site 648999000083 active site 648999000084 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 648999000085 putative deacylase active site [active] 648999000086 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 648999000087 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 648999000088 catalytic residues [active] 648999000089 Fe-S metabolism associated domain; Region: SufE; cl00951 648999000090 FOG: CBS domain [General function prediction only]; Region: COG0517 648999000091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 648999000092 prolyl-tRNA synthetase; Provisional; Region: PRK09194 648999000093 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 648999000094 dimer interface [polypeptide binding]; other site 648999000095 motif 1; other site 648999000096 active site 648999000097 motif 2; other site 648999000098 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 648999000099 putative deacylase active site [active] 648999000100 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 648999000101 active site 648999000102 motif 3; other site 648999000103 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 648999000104 anticodon binding site; other site 648999000105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999000106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000107 active site 648999000108 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999000109 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999000110 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999000112 Walker A/P-loop; other site 648999000113 ATP binding site [chemical binding]; other site 648999000114 Q-loop/lid; other site 648999000115 ABC transporter signature motif; other site 648999000116 Walker B; other site 648999000117 D-loop; other site 648999000118 H-loop/switch region; other site 648999000119 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 648999000120 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999000121 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999000123 S-adenosylmethionine binding site [chemical binding]; other site 648999000124 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999000125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 648999000126 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999000127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999000128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999000129 DNA binding residues [nucleotide binding] 648999000130 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 648999000131 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999000132 PQQ-like domain; Region: PQQ_2; pfam13360 648999000133 Trp docking motif [polypeptide binding]; other site 648999000134 active site 648999000135 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999000136 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 648999000137 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 648999000138 active site 648999000139 catalytic triad [active] 648999000140 oxyanion hole [active] 648999000141 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 648999000142 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 648999000143 active site residue [active] 648999000144 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 648999000145 active site residue [active] 648999000146 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999000147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999000148 DNA binding residues [nucleotide binding] 648999000149 FAD binding domain; Region: FAD_binding_3; pfam01494 648999000150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999000151 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999000152 HSP90 family protein; Provisional; Region: PRK14083 648999000153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999000154 ATP binding site [chemical binding]; other site 648999000155 Mg2+ binding site [ion binding]; other site 648999000156 G-X-G motif; other site 648999000157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999000158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999000159 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 648999000160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999000161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999000162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 648999000163 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 648999000164 active site 648999000165 catalytic residues [active] 648999000166 metal binding site [ion binding]; metal-binding site 648999000167 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 648999000168 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 648999000169 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 648999000170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999000171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999000172 active site 648999000173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999000174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999000175 non-specific DNA binding site [nucleotide binding]; other site 648999000176 salt bridge; other site 648999000177 sequence-specific DNA binding site [nucleotide binding]; other site 648999000178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999000179 MarR family; Region: MarR; pfam01047 648999000180 Uncharacterized conserved protein [Function unknown]; Region: COG2353 648999000181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999000182 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 648999000183 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999000184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999000185 sequence-specific DNA binding site [nucleotide binding]; other site 648999000186 salt bridge; other site 648999000187 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999000188 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 648999000189 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 648999000190 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 648999000191 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 648999000192 NAD binding site [chemical binding]; other site 648999000193 homotetramer interface [polypeptide binding]; other site 648999000194 homodimer interface [polypeptide binding]; other site 648999000195 active site 648999000196 substrate binding site [chemical binding]; other site 648999000197 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 648999000198 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 648999000199 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 648999000200 phosphopeptide binding site; other site 648999000201 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 648999000202 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 648999000203 phosphopeptide binding site; other site 648999000204 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 648999000205 active site 648999000206 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 648999000207 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 648999000208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999000209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999000210 active site 648999000211 ATP binding site [chemical binding]; other site 648999000212 substrate binding site [chemical binding]; other site 648999000213 activation loop (A-loop); other site 648999000214 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 648999000215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999000216 active site 648999000217 ATP binding site [chemical binding]; other site 648999000218 substrate binding site [chemical binding]; other site 648999000219 activation loop (A-loop); other site 648999000220 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999000221 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999000222 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999000223 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 648999000224 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 648999000225 glutamine binding [chemical binding]; other site 648999000226 catalytic triad [active] 648999000227 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 648999000228 active site 648999000229 catalytic site [active] 648999000230 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 648999000231 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 648999000232 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 648999000233 4Fe-4S binding domain; Region: Fer4; pfam00037 648999000234 Cysteine-rich domain; Region: CCG; pfam02754 648999000235 Cysteine-rich domain; Region: CCG; pfam02754 648999000236 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 648999000237 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999000238 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999000239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999000240 Transporter associated domain; Region: CorC_HlyC; smart01091 648999000241 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999000242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999000243 FOG: CBS domain [General function prediction only]; Region: COG0517 648999000244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 648999000245 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999000246 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999000247 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 648999000248 amidase catalytic site [active] 648999000249 Zn binding residues [ion binding]; other site 648999000250 substrate binding site [chemical binding]; other site 648999000251 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999000252 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999000253 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 648999000254 trimer interface [polypeptide binding]; other site 648999000255 active site 648999000256 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999000257 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 648999000258 active site 648999000259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999000260 hydrophobic ligand binding site; other site 648999000261 RibD C-terminal domain; Region: RibD_C; cl17279 648999000262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999000263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999000264 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 648999000265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000266 active site 648999000267 metal binding site [ion binding]; metal-binding site 648999000268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999000269 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 648999000270 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 648999000271 dimerization interface [polypeptide binding]; other site 648999000272 substrate binding pocket [chemical binding]; other site 648999000273 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999000274 nudix motif; other site 648999000275 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 648999000276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999000277 DNA binding residues [nucleotide binding] 648999000278 drug binding residues [chemical binding]; other site 648999000279 dimer interface [polypeptide binding]; other site 648999000280 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 648999000281 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 648999000282 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999000283 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 648999000284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999000285 active site 648999000286 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 648999000287 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 648999000288 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999000289 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 648999000290 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 648999000291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999000292 active site 648999000293 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 648999000294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999000295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999000296 active site 648999000297 catalytic tetrad [active] 648999000298 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999000299 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999000300 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 648999000301 catalytic core [active] 648999000302 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 648999000303 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 648999000304 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 648999000305 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 648999000306 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 648999000307 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 648999000308 putative active site [active] 648999000309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999000310 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999000311 NHL repeat; Region: NHL; pfam01436 648999000312 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999000313 E3 interaction surface; other site 648999000314 lipoyl attachment site [posttranslational modification]; other site 648999000315 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 648999000316 e3 binding domain; Region: E3_binding; pfam02817 648999000317 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999000318 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999000319 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 648999000320 alpha subunit interface [polypeptide binding]; other site 648999000321 TPP binding site [chemical binding]; other site 648999000322 heterodimer interface [polypeptide binding]; other site 648999000323 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999000324 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 648999000325 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 648999000326 TPP-binding site [chemical binding]; other site 648999000327 tetramer interface [polypeptide binding]; other site 648999000328 heterodimer interface [polypeptide binding]; other site 648999000329 phosphorylation loop region [posttranslational modification] 648999000330 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 648999000331 G1 box; other site 648999000332 GTP/Mg2+ binding site [chemical binding]; other site 648999000333 G2 box; other site 648999000334 Switch I region; other site 648999000335 G3 box; other site 648999000336 Switch II region; other site 648999000337 G4 box; other site 648999000338 Dynamin family; Region: Dynamin_N; pfam00350 648999000339 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 648999000340 G1 box; other site 648999000341 GTP/Mg2+ binding site [chemical binding]; other site 648999000342 G2 box; other site 648999000343 Switch I region; other site 648999000344 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 648999000345 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 648999000346 nucleotide binding site [chemical binding]; other site 648999000347 NEF interaction site [polypeptide binding]; other site 648999000348 SBD interface [polypeptide binding]; other site 648999000349 GrpE; Region: GrpE; pfam01025 648999000350 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 648999000351 dimer interface [polypeptide binding]; other site 648999000352 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 648999000353 chaperone protein DnaJ; Provisional; Region: PRK14279 648999000354 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 648999000355 HSP70 interaction site [polypeptide binding]; other site 648999000356 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 648999000357 Zn binding sites [ion binding]; other site 648999000358 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 648999000359 dimer interface [polypeptide binding]; other site 648999000360 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999000361 DNA binding residues [nucleotide binding] 648999000362 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999000363 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 648999000364 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 648999000365 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 648999000366 TrkA-C domain; Region: TrkA_C; pfam02080 648999000367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999000368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999000369 DNA-binding site [nucleotide binding]; DNA binding site 648999000370 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999000371 DivIVA protein; Region: DivIVA; pfam05103 648999000372 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 648999000373 Clp amino terminal domain; Region: Clp_N; pfam02861 648999000374 Clp amino terminal domain; Region: Clp_N; pfam02861 648999000375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999000376 Walker A motif; other site 648999000377 ATP binding site [chemical binding]; other site 648999000378 Walker B motif; other site 648999000379 arginine finger; other site 648999000380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999000381 Walker A motif; other site 648999000382 ATP binding site [chemical binding]; other site 648999000383 Walker B motif; other site 648999000384 arginine finger; other site 648999000385 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 648999000386 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 648999000387 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 648999000388 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 648999000389 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 648999000390 spermidine synthase; Provisional; Region: PRK03612 648999000391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999000392 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 648999000393 classical (c) SDRs; Region: SDR_c; cd05233 648999000394 NAD(P) binding site [chemical binding]; other site 648999000395 active site 648999000396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999000397 active site 648999000398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000399 dimerization interface [polypeptide binding]; other site 648999000400 putative DNA binding site [nucleotide binding]; other site 648999000401 putative Zn2+ binding site [ion binding]; other site 648999000402 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999000403 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 648999000404 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 648999000405 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 648999000406 active site 648999000407 metal binding site [ion binding]; metal-binding site 648999000408 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 648999000409 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 648999000410 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999000411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999000412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999000413 DNA binding residues [nucleotide binding] 648999000414 Transcriptional regulator [Transcription]; Region: LytR; COG1316 648999000415 Predicted membrane protein [Function unknown]; Region: COG1950 648999000416 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 648999000417 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 648999000418 active site 648999000419 intersubunit interface [polypeptide binding]; other site 648999000420 zinc binding site [ion binding]; other site 648999000421 Na+ binding site [ion binding]; other site 648999000422 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 648999000423 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 648999000424 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 648999000425 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 648999000426 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 648999000427 GDP-binding site [chemical binding]; other site 648999000428 ACT binding site; other site 648999000429 IMP binding site; other site 648999000430 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 648999000431 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 648999000432 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 648999000433 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 648999000434 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 648999000435 acyl-CoA synthetase; Validated; Region: PRK07788 648999000436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999000437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999000438 acyl-activating enzyme (AAE) consensus motif; other site 648999000439 AMP binding site [chemical binding]; other site 648999000440 active site 648999000441 acyl-activating enzyme (AAE) consensus motif; other site 648999000442 CoA binding site [chemical binding]; other site 648999000443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999000444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999000445 active site 648999000446 SCP-2 sterol transfer family; Region: SCP2; pfam02036 648999000447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999000448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999000449 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999000450 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999000451 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 648999000452 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 648999000453 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 648999000454 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 648999000455 active site 648999000456 substrate binding site [chemical binding]; other site 648999000457 activation loop (A-loop); other site 648999000458 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 648999000459 nudix motif; other site 648999000460 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 648999000461 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 648999000462 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 648999000463 active site 1 [active] 648999000464 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 648999000465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999000466 NAD(P) binding site [chemical binding]; other site 648999000467 active site 648999000468 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 648999000469 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999000470 dimer interface [polypeptide binding]; other site 648999000471 active site 648999000472 Right handed beta helix region; Region: Beta_helix; pfam13229 648999000473 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 648999000474 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 648999000475 PKC phosphorylation site [posttranslational modification]; other site 648999000476 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 648999000477 PKC phosphorylation site [posttranslational modification]; other site 648999000478 adenylosuccinate lyase; Region: purB; TIGR00928 648999000479 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 648999000480 tetramer interface [polypeptide binding]; other site 648999000481 Uncharacterized conserved protein [Function unknown]; Region: COG0393 648999000482 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 648999000483 active site 648999000484 substrate binding sites [chemical binding]; other site 648999000485 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 648999000486 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 648999000487 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 648999000488 putative active site [active] 648999000489 catalytic triad [active] 648999000490 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 648999000491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 648999000492 dimerization interface [polypeptide binding]; other site 648999000493 ATP binding site [chemical binding]; other site 648999000494 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 648999000495 dimerization interface [polypeptide binding]; other site 648999000496 ATP binding site [chemical binding]; other site 648999000497 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 648999000498 amidophosphoribosyltransferase; Provisional; Region: PRK07847 648999000499 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 648999000500 active site 648999000501 tetramer interface [polypeptide binding]; other site 648999000502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999000503 active site 648999000504 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 648999000505 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 648999000506 dimerization interface [polypeptide binding]; other site 648999000507 putative ATP binding site [chemical binding]; other site 648999000508 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 648999000509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999000510 FeS/SAM binding site; other site 648999000511 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 648999000512 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 648999000513 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 648999000514 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 648999000515 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 648999000516 NAD binding site [chemical binding]; other site 648999000517 Phe binding site; other site 648999000518 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 648999000519 DNA binding residues [nucleotide binding] 648999000520 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 648999000521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999000522 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 648999000523 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999000524 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999000525 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 648999000526 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999000527 substrate binding site [chemical binding]; other site 648999000528 oxyanion hole (OAH) forming residues; other site 648999000529 trimer interface [polypeptide binding]; other site 648999000530 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 648999000531 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999000532 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 648999000533 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 648999000534 putative hydrophobic ligand binding site [chemical binding]; other site 648999000535 CLM binding site; other site 648999000536 L1 loop; other site 648999000537 DNA binding site [nucleotide binding] 648999000538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000539 putative DNA binding site [nucleotide binding]; other site 648999000540 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999000541 putative Zn2+ binding site [ion binding]; other site 648999000542 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 648999000543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000544 putative metal binding site [ion binding]; other site 648999000545 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 648999000546 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 648999000547 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999000548 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 648999000549 NodB motif; other site 648999000550 active site 648999000551 catalytic site [active] 648999000552 metal binding site [ion binding]; metal-binding site 648999000553 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999000554 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999000555 DNA binding residues [nucleotide binding] 648999000556 B12 binding domain; Region: B12-binding_2; pfam02607 648999000557 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 648999000558 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 648999000559 active site 648999000560 metal binding site [ion binding]; metal-binding site 648999000561 nudix motif; other site 648999000562 phytoene desaturase; Region: crtI_fam; TIGR02734 648999000563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999000564 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999000565 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999000566 substrate binding pocket [chemical binding]; other site 648999000567 chain length determination region; other site 648999000568 substrate-Mg2+ binding site; other site 648999000569 catalytic residues [active] 648999000570 aspartate-rich region 1; other site 648999000571 active site lid residues [active] 648999000572 aspartate-rich region 2; other site 648999000573 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 648999000574 active site lid residues [active] 648999000575 substrate binding pocket [chemical binding]; other site 648999000576 catalytic residues [active] 648999000577 substrate-Mg2+ binding site; other site 648999000578 aspartate-rich region 1; other site 648999000579 aspartate-rich region 2; other site 648999000580 DNA photolyase; Region: DNA_photolyase; pfam00875 648999000581 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 648999000582 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999000583 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999000584 mercuric reductase; Validated; Region: PRK06370 648999000585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999000586 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999000587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999000588 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 648999000589 substrate binding site [chemical binding]; other site 648999000590 oxyanion hole (OAH) forming residues; other site 648999000591 trimer interface [polypeptide binding]; other site 648999000592 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 648999000593 iron-sulfur cluster [ion binding]; other site 648999000594 [2Fe-2S] cluster binding site [ion binding]; other site 648999000595 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 648999000596 TadE-like protein; Region: TadE; pfam07811 648999000597 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 648999000598 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 648999000599 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 648999000600 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999000601 Walker A motif; other site 648999000602 ATP binding site [chemical binding]; other site 648999000603 Walker B motif; other site 648999000604 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 648999000605 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 648999000606 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 648999000607 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 648999000608 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 648999000609 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 648999000610 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999000611 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 648999000612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999000613 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999000614 Uncharacterized conserved protein [Function unknown]; Region: COG2128 648999000615 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 648999000616 Epoxide hydrolase N terminus; Region: EHN; pfam06441 648999000617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999000618 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999000619 MarR family; Region: MarR; pfam01047 648999000620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000621 putative DNA binding site [nucleotide binding]; other site 648999000622 putative Zn2+ binding site [ion binding]; other site 648999000623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999000624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999000625 Walker A/P-loop; other site 648999000626 ATP binding site [chemical binding]; other site 648999000627 Q-loop/lid; other site 648999000628 ABC transporter signature motif; other site 648999000629 Walker B; other site 648999000630 D-loop; other site 648999000631 H-loop/switch region; other site 648999000632 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 648999000633 putative active site [active] 648999000634 Domain of unknown function DUF87; Region: DUF87; pfam01935 648999000635 AAA-like domain; Region: AAA_10; pfam12846 648999000636 Zonular occludens toxin (Zot); Region: Zot; cl17485 648999000637 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999000638 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 648999000639 putative NAD(P) binding site [chemical binding]; other site 648999000640 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999000641 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999000642 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 648999000643 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999000644 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999000645 putative sugar binding sites [chemical binding]; other site 648999000646 Q-X-W motif; other site 648999000647 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999000648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999000649 S-adenosylmethionine binding site [chemical binding]; other site 648999000650 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999000651 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999000652 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 648999000653 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999000654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999000655 Histidine kinase; Region: HisKA_3; pfam07730 648999000656 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999000657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999000658 active site 648999000659 phosphorylation site [posttranslational modification] 648999000660 intermolecular recognition site; other site 648999000661 dimerization interface [polypeptide binding]; other site 648999000662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999000663 DNA binding residues [nucleotide binding] 648999000664 dimerization interface [polypeptide binding]; other site 648999000665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999000666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999000667 NAD(P) binding site [chemical binding]; other site 648999000668 active site 648999000669 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 648999000670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 648999000671 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 648999000672 Coenzyme A binding pocket [chemical binding]; other site 648999000673 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 648999000674 Protein phosphatase 2C; Region: PP2C; pfam00481 648999000675 active site 648999000676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999000677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999000678 non-specific DNA binding site [nucleotide binding]; other site 648999000679 salt bridge; other site 648999000680 sequence-specific DNA binding site [nucleotide binding]; other site 648999000681 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 648999000682 benzoate transporter; Region: benE; TIGR00843 648999000683 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 648999000684 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 648999000685 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 648999000686 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999000687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999000688 DNA-binding site [nucleotide binding]; DNA binding site 648999000689 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 648999000690 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999000691 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 648999000692 anti sigma factor interaction site; other site 648999000693 regulatory phosphorylation site [posttranslational modification]; other site 648999000694 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 648999000695 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 648999000696 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 648999000697 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999000698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 648999000699 ATP binding site [chemical binding]; other site 648999000700 Mg2+ binding site [ion binding]; other site 648999000701 G-X-G motif; other site 648999000702 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 648999000703 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 648999000704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999000705 dimer interface [polypeptide binding]; other site 648999000706 phosphorylation site [posttranslational modification] 648999000707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999000708 ATP binding site [chemical binding]; other site 648999000709 Mg2+ binding site [ion binding]; other site 648999000710 G-X-G motif; other site 648999000711 Response regulator receiver domain; Region: Response_reg; pfam00072 648999000712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999000713 active site 648999000714 phosphorylation site [posttranslational modification] 648999000715 intermolecular recognition site; other site 648999000716 dimerization interface [polypeptide binding]; other site 648999000717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999000718 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 648999000719 TIGR03086 family protein; Region: TIGR03086 648999000720 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999000721 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999000722 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999000723 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999000724 Walker A/P-loop; other site 648999000725 ATP binding site [chemical binding]; other site 648999000726 Q-loop/lid; other site 648999000727 ABC transporter signature motif; other site 648999000728 Walker B; other site 648999000729 D-loop; other site 648999000730 H-loop/switch region; other site 648999000731 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 648999000732 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999000733 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 648999000734 FAD binding domain; Region: FAD_binding_4; pfam01565 648999000735 GAF domain; Region: GAF_3; pfam13492 648999000736 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999000737 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 648999000738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000739 dimerization interface [polypeptide binding]; other site 648999000740 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 648999000741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000742 dimerization interface [polypeptide binding]; other site 648999000743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000744 dimerization interface [polypeptide binding]; other site 648999000745 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 648999000746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000747 dimerization interface [polypeptide binding]; other site 648999000748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000749 dimerization interface [polypeptide binding]; other site 648999000750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000751 dimerization interface [polypeptide binding]; other site 648999000752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999000753 dimerization interface [polypeptide binding]; other site 648999000754 GAF domain; Region: GAF_2; pfam13185 648999000755 GAF domain; Region: GAF; pfam01590 648999000756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999000757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999000758 ATP binding site [chemical binding]; other site 648999000759 Mg2+ binding site [ion binding]; other site 648999000760 G-X-G motif; other site 648999000761 Response regulator receiver domain; Region: Response_reg; pfam00072 648999000762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999000763 active site 648999000764 phosphorylation site [posttranslational modification] 648999000765 intermolecular recognition site; other site 648999000766 dimerization interface [polypeptide binding]; other site 648999000767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999000768 Response regulator receiver domain; Region: Response_reg; pfam00072 648999000769 active site 648999000770 phosphorylation site [posttranslational modification] 648999000771 intermolecular recognition site; other site 648999000772 dimerization interface [polypeptide binding]; other site 648999000773 Predicted transcriptional regulators [Transcription]; Region: COG1510 648999000774 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999000775 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999000776 Walker A/P-loop; other site 648999000777 ATP binding site [chemical binding]; other site 648999000778 Q-loop/lid; other site 648999000779 ABC transporter signature motif; other site 648999000780 Walker B; other site 648999000781 D-loop; other site 648999000782 H-loop/switch region; other site 648999000783 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 648999000784 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 648999000785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999000786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999000787 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999000788 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999000789 anti sigma factor interaction site; other site 648999000790 regulatory phosphorylation site [posttranslational modification]; other site 648999000791 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 648999000792 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999000793 inhibitor-cofactor binding pocket; inhibition site 648999000794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999000795 catalytic residue [active] 648999000796 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999000797 catalytic core [active] 648999000798 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 648999000799 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999000800 catalytic residues [active] 648999000801 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 648999000802 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 648999000803 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 648999000804 ResB-like family; Region: ResB; pfam05140 648999000805 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 648999000806 Archaeal ATPase; Region: Arch_ATPase; pfam01637 648999000807 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999000808 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 648999000809 Uncharacterized conserved protein [Function unknown]; Region: COG2128 648999000810 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 648999000811 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 648999000812 prenyltransferase; Reviewed; Region: ubiA; PRK12888 648999000813 UbiA prenyltransferase family; Region: UbiA; pfam01040 648999000814 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 648999000815 substrate binding pocket [chemical binding]; other site 648999000816 substrate-Mg2+ binding site; other site 648999000817 aspartate-rich region 1; other site 648999000818 aspartate-rich region 2; other site 648999000819 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 648999000820 Flavoprotein; Region: Flavoprotein; pfam02441 648999000821 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 648999000822 DNA binding residues [nucleotide binding] 648999000823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 648999000824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000825 putative DNA binding site [nucleotide binding]; other site 648999000826 putative Zn2+ binding site [ion binding]; other site 648999000827 AsnC family; Region: AsnC_trans_reg; pfam01037 648999000828 classical (c) SDRs; Region: SDR_c; cd05233 648999000829 NAD(P) binding site [chemical binding]; other site 648999000830 active site 648999000831 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 648999000832 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 648999000833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999000834 catalytic residue [active] 648999000835 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 648999000836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 648999000837 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999000838 ATP binding site [chemical binding]; other site 648999000839 Mg++ binding site [ion binding]; other site 648999000840 motif III; other site 648999000841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999000842 nucleotide binding region [chemical binding]; other site 648999000843 ATP-binding site [chemical binding]; other site 648999000844 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999000845 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999000846 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 648999000847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999000848 FeS/SAM binding site; other site 648999000849 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 648999000850 putative active site [active] 648999000851 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 648999000852 putative active site [active] 648999000853 Zn binding site [ion binding]; other site 648999000854 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 648999000855 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 648999000856 putative binding site residues; other site 648999000857 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 648999000858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999000859 ABC-ATPase subunit interface; other site 648999000860 dimer interface [polypeptide binding]; other site 648999000861 putative PBP binding regions; other site 648999000862 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999000863 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 648999000864 Walker A/P-loop; other site 648999000865 ATP binding site [chemical binding]; other site 648999000866 Q-loop/lid; other site 648999000867 ABC transporter signature motif; other site 648999000868 Walker B; other site 648999000869 D-loop; other site 648999000870 H-loop/switch region; other site 648999000871 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999000872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999000873 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999000874 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 648999000875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000876 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 648999000877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999000878 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999000879 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999000880 Walker A/P-loop; other site 648999000881 ATP binding site [chemical binding]; other site 648999000882 Q-loop/lid; other site 648999000883 ABC transporter signature motif; other site 648999000884 Walker B; other site 648999000885 D-loop; other site 648999000886 H-loop/switch region; other site 648999000887 Proteins of 100 residues with WXG; Region: WXG100; cl02005 648999000888 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 648999000889 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 648999000890 Anticodon-binding domain; Region: AD; cl10767 648999000891 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 648999000892 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999000893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999000894 non-specific DNA binding site [nucleotide binding]; other site 648999000895 salt bridge; other site 648999000896 sequence-specific DNA binding site [nucleotide binding]; other site 648999000897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999000898 putative DNA binding site [nucleotide binding]; other site 648999000899 dimerization interface [polypeptide binding]; other site 648999000900 putative Zn2+ binding site [ion binding]; other site 648999000901 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 648999000902 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 648999000903 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 648999000904 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 648999000905 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 648999000906 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 648999000907 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 648999000908 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 648999000909 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 648999000910 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 648999000911 FAD binding pocket [chemical binding]; other site 648999000912 FAD binding motif [chemical binding]; other site 648999000913 phosphate binding motif [ion binding]; other site 648999000914 beta-alpha-beta structure motif; other site 648999000915 NAD(p) ribose binding residues [chemical binding]; other site 648999000916 NAD binding pocket [chemical binding]; other site 648999000917 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 648999000918 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 648999000919 catalytic loop [active] 648999000920 iron binding site [ion binding]; other site 648999000921 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 648999000922 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 648999000923 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 648999000924 putative active site [active] 648999000925 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 648999000926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999000927 FeS/SAM binding site; other site 648999000928 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 648999000929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999000930 S-adenosylmethionine binding site [chemical binding]; other site 648999000931 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 648999000932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999000933 NADH dehydrogenase subunit A; Validated; Region: PRK07928 648999000934 NADH dehydrogenase subunit B; Validated; Region: PRK06411 648999000935 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 648999000936 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 648999000937 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 648999000938 NADH dehydrogenase subunit D; Validated; Region: PRK06075 648999000939 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 648999000940 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 648999000941 putative dimer interface [polypeptide binding]; other site 648999000942 [2Fe-2S] cluster binding site [ion binding]; other site 648999000943 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 648999000944 SLBB domain; Region: SLBB; pfam10531 648999000945 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 648999000946 NADH dehydrogenase subunit G; Validated; Region: PRK07860 648999000947 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 648999000948 catalytic loop [active] 648999000949 iron binding site [ion binding]; other site 648999000950 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 648999000951 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999000952 molybdopterin cofactor binding site; other site 648999000953 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 648999000954 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 648999000955 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 648999000956 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 648999000957 4Fe-4S binding domain; Region: Fer4; pfam00037 648999000958 4Fe-4S binding domain; Region: Fer4; pfam00037 648999000959 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 648999000960 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 648999000961 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 648999000962 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 648999000963 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 648999000964 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999000965 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 648999000966 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999000967 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 648999000968 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999000969 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999000970 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999000971 substrate binding pocket [chemical binding]; other site 648999000972 chain length determination region; other site 648999000973 substrate-Mg2+ binding site; other site 648999000974 catalytic residues [active] 648999000975 aspartate-rich region 1; other site 648999000976 active site lid residues [active] 648999000977 aspartate-rich region 2; other site 648999000978 Transcriptional regulator [Transcription]; Region: IclR; COG1414 648999000979 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 648999000980 Bacterial transcriptional regulator; Region: IclR; pfam01614 648999000981 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 648999000982 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 648999000983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999000984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999000985 DNA binding residues [nucleotide binding] 648999000986 Putative zinc-finger; Region: zf-HC2; pfam13490 648999000987 Predicted permeases [General function prediction only]; Region: RarD; COG2962 648999000988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999000989 Coenzyme A binding pocket [chemical binding]; other site 648999000990 Membrane protein of unknown function; Region: DUF360; pfam04020 648999000991 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 648999000992 Proteins of 100 residues with WXG; Region: WXG100; cl02005 648999000993 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 648999000994 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999000995 active site 648999000996 catalytic residues [active] 648999000997 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999000998 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 648999000999 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 648999001000 acetyl-CoA synthetase; Provisional; Region: PRK00174 648999001001 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 648999001002 active site 648999001003 CoA binding site [chemical binding]; other site 648999001004 acyl-activating enzyme (AAE) consensus motif; other site 648999001005 AMP binding site [chemical binding]; other site 648999001006 acetate binding site [chemical binding]; other site 648999001007 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 648999001008 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 648999001009 Phosphotransferase enzyme family; Region: APH; pfam01636 648999001010 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999001011 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 648999001012 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 648999001013 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 648999001014 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 648999001015 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 648999001016 Walker A motif; other site 648999001017 ATP binding site [chemical binding]; other site 648999001018 Walker B motif; other site 648999001019 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 648999001020 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 648999001021 Tubby C 2; Region: Tub_2; cl02043 648999001022 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 648999001023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999001024 ATP binding site [chemical binding]; other site 648999001025 putative Mg++ binding site [ion binding]; other site 648999001026 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 648999001027 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999001028 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 648999001029 anti sigma factor interaction site; other site 648999001030 regulatory phosphorylation site [posttranslational modification]; other site 648999001031 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999001032 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 648999001033 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 648999001034 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 648999001035 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 648999001036 active site 648999001037 interdomain interaction site; other site 648999001038 putative metal-binding site [ion binding]; other site 648999001039 nucleotide binding site [chemical binding]; other site 648999001040 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 648999001041 domain I; other site 648999001042 phosphate binding site [ion binding]; other site 648999001043 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 648999001044 domain II; other site 648999001045 domain III; other site 648999001046 nucleotide binding site [chemical binding]; other site 648999001047 DNA binding groove [nucleotide binding] 648999001048 catalytic site [active] 648999001049 domain IV; other site 648999001050 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 648999001051 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 648999001052 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 648999001053 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 648999001054 FAD binding domain; Region: FAD_binding_4; pfam01565 648999001055 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 648999001056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999001057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999001058 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 648999001059 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 648999001060 dimer interface [polypeptide binding]; other site 648999001061 active site 648999001062 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999001063 substrate binding site [chemical binding]; other site 648999001064 catalytic residue [active] 648999001065 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999001067 thymidylate kinase; Validated; Region: tmk; PRK00698 648999001068 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 648999001069 TMP-binding site; other site 648999001070 ATP-binding site [chemical binding]; other site 648999001071 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 648999001072 DNA polymerase III subunit delta'; Validated; Region: PRK08485 648999001073 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 648999001074 PSP1 C-terminal conserved region; Region: PSP1; cl00770 648999001075 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999001076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999001077 salt bridge; other site 648999001078 non-specific DNA binding site [nucleotide binding]; other site 648999001079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999001080 sequence-specific DNA binding site [nucleotide binding]; other site 648999001081 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 648999001082 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 648999001083 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 648999001084 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 648999001085 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 648999001086 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 648999001087 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 648999001088 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 648999001089 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 648999001090 putative dimer interface [polypeptide binding]; other site 648999001091 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 648999001092 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 648999001093 putative active site [active] 648999001094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999001095 active site 648999001096 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999001097 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 648999001098 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 648999001099 active site 648999001100 nucleotide binding site [chemical binding]; other site 648999001101 HIGH motif; other site 648999001102 KMSKS motif; other site 648999001103 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 648999001104 intracellular protease, PfpI family; Region: PfpI; TIGR01382 648999001105 proposed catalytic triad [active] 648999001106 conserved cys residue [active] 648999001107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999001108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999001109 putative substrate translocation pore; other site 648999001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999001111 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999001112 nudix motif; other site 648999001113 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 648999001114 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 648999001115 dimer interface [polypeptide binding]; other site 648999001116 acyl-activating enzyme (AAE) consensus motif; other site 648999001117 putative active site [active] 648999001118 AMP binding site [chemical binding]; other site 648999001119 putative CoA binding site [chemical binding]; other site 648999001120 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 648999001121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999001122 NAD(P) binding site [chemical binding]; other site 648999001123 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 648999001124 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 648999001125 NAD binding site [chemical binding]; other site 648999001126 catalytic Zn binding site [ion binding]; other site 648999001127 structural Zn binding site [ion binding]; other site 648999001128 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 648999001129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 648999001130 motif I; other site 648999001131 active site 648999001132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999001133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 648999001134 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 648999001135 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 648999001136 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 648999001137 putative DNA binding site [nucleotide binding]; other site 648999001138 putative homodimer interface [polypeptide binding]; other site 648999001139 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 648999001140 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 648999001141 active site 648999001142 DNA binding site [nucleotide binding] 648999001143 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 648999001144 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 648999001145 nucleotide binding site [chemical binding]; other site 648999001146 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 648999001147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999001148 WHG domain; Region: WHG; pfam13305 648999001149 TIGR03089 family protein; Region: TIGR03089 648999001150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999001151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999001152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999001153 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 648999001154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999001155 active site 648999001156 HIGH motif; other site 648999001157 nucleotide binding site [chemical binding]; other site 648999001158 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999001159 active site 648999001160 KMSKS motif; other site 648999001161 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 648999001162 tRNA binding surface [nucleotide binding]; other site 648999001163 anticodon binding site; other site 648999001164 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999001165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999001166 Walker A/P-loop; other site 648999001167 ATP binding site [chemical binding]; other site 648999001168 Q-loop/lid; other site 648999001169 ABC transporter signature motif; other site 648999001170 Walker B; other site 648999001171 D-loop; other site 648999001172 H-loop/switch region; other site 648999001173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999001174 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999001175 Walker A/P-loop; other site 648999001176 ATP binding site [chemical binding]; other site 648999001177 Q-loop/lid; other site 648999001178 ABC transporter signature motif; other site 648999001179 Walker B; other site 648999001180 D-loop; other site 648999001181 H-loop/switch region; other site 648999001182 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 648999001183 PUA-like domain; Region: PUA_2; pfam14306 648999001184 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 648999001185 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 648999001186 ligand-binding site [chemical binding]; other site 648999001187 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 648999001188 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 648999001189 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 648999001190 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 648999001191 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 648999001192 dimer interface [polypeptide binding]; other site 648999001193 active site 648999001194 isocitrate dehydrogenase; Validated; Region: PRK08299 648999001195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999001196 malate dehydrogenase; Reviewed; Region: PRK06223 648999001197 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 648999001198 NAD(P) binding site [chemical binding]; other site 648999001199 dimer interface [polypeptide binding]; other site 648999001200 tetramer (dimer of dimers) interface [polypeptide binding]; other site 648999001201 substrate binding site [chemical binding]; other site 648999001202 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 648999001203 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 648999001204 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 648999001205 homodimer interface [polypeptide binding]; other site 648999001206 NADP binding site [chemical binding]; other site 648999001207 substrate binding site [chemical binding]; other site 648999001208 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 648999001209 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 648999001210 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999001211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999001212 dimer interface [polypeptide binding]; other site 648999001213 conserved gate region; other site 648999001214 putative PBP binding loops; other site 648999001215 ABC-ATPase subunit interface; other site 648999001216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999001218 dimer interface [polypeptide binding]; other site 648999001219 conserved gate region; other site 648999001220 putative PBP binding loops; other site 648999001221 ABC-ATPase subunit interface; other site 648999001222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999001223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999001224 Walker A/P-loop; other site 648999001225 ATP binding site [chemical binding]; other site 648999001226 Q-loop/lid; other site 648999001227 ABC transporter signature motif; other site 648999001228 Walker B; other site 648999001229 D-loop; other site 648999001230 H-loop/switch region; other site 648999001231 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999001232 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 648999001233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999001234 Walker A/P-loop; other site 648999001235 ATP binding site [chemical binding]; other site 648999001236 Q-loop/lid; other site 648999001237 ABC transporter signature motif; other site 648999001238 Walker B; other site 648999001239 D-loop; other site 648999001240 H-loop/switch region; other site 648999001241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999001242 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 648999001243 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 648999001244 purine monophosphate binding site [chemical binding]; other site 648999001245 dimer interface [polypeptide binding]; other site 648999001246 putative catalytic residues [active] 648999001247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 648999001248 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 648999001249 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 648999001250 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 648999001251 active site 648999001252 substrate binding site [chemical binding]; other site 648999001253 cosubstrate binding site; other site 648999001254 catalytic site [active] 648999001255 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 648999001256 CoA binding domain; Region: CoA_binding; smart00881 648999001257 CoA-ligase; Region: Ligase_CoA; pfam00549 648999001258 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 648999001259 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 648999001260 CoA-ligase; Region: Ligase_CoA; pfam00549 648999001261 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 648999001262 B12 binding site [chemical binding]; other site 648999001263 cobalt ligand [ion binding]; other site 648999001264 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999001265 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999001266 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999001267 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999001268 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 648999001269 Part of AAA domain; Region: AAA_19; pfam13245 648999001270 Family description; Region: UvrD_C_2; pfam13538 648999001271 Chorismate mutase type II; Region: CM_2; cl00693 648999001272 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 648999001273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999001274 Walker A/P-loop; other site 648999001275 ATP binding site [chemical binding]; other site 648999001276 Q-loop/lid; other site 648999001277 ABC transporter signature motif; other site 648999001278 Walker B; other site 648999001279 D-loop; other site 648999001280 H-loop/switch region; other site 648999001281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999001282 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999001283 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999001284 Walker A/P-loop; other site 648999001285 ATP binding site [chemical binding]; other site 648999001286 Q-loop/lid; other site 648999001287 ABC transporter signature motif; other site 648999001288 Walker B; other site 648999001289 D-loop; other site 648999001290 H-loop/switch region; other site 648999001291 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999001292 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999001293 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 648999001294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999001295 dimer interface [polypeptide binding]; other site 648999001296 conserved gate region; other site 648999001297 putative PBP binding loops; other site 648999001298 ABC-ATPase subunit interface; other site 648999001299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999001300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999001301 dimer interface [polypeptide binding]; other site 648999001302 conserved gate region; other site 648999001303 putative PBP binding loops; other site 648999001304 ABC-ATPase subunit interface; other site 648999001305 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 648999001306 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999001307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999001309 active site 648999001310 phosphorylation site [posttranslational modification] 648999001311 intermolecular recognition site; other site 648999001312 dimerization interface [polypeptide binding]; other site 648999001313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999001314 DNA binding residues [nucleotide binding] 648999001315 dimerization interface [polypeptide binding]; other site 648999001316 PspC domain; Region: PspC; pfam04024 648999001317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999001318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999001319 ATP binding site [chemical binding]; other site 648999001320 G-X-G motif; other site 648999001321 PspC domain; Region: PspC; cl00864 648999001322 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 648999001323 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 648999001324 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 648999001325 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999001326 nudix motif; other site 648999001327 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999001328 nudix motif; other site 648999001329 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 648999001330 nudix motif; other site 648999001331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999001332 nudix motif; other site 648999001333 PspC domain; Region: PspC; pfam04024 648999001334 GMP synthase; Reviewed; Region: guaA; PRK00074 648999001335 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 648999001336 AMP/PPi binding site [chemical binding]; other site 648999001337 candidate oxyanion hole; other site 648999001338 catalytic triad [active] 648999001339 potential glutamine specificity residues [chemical binding]; other site 648999001340 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 648999001341 ATP Binding subdomain [chemical binding]; other site 648999001342 Ligand Binding sites [chemical binding]; other site 648999001343 Dimerization subdomain; other site 648999001344 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 648999001345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999001346 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 648999001347 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 648999001348 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 648999001349 Zn binding site [ion binding]; other site 648999001350 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 648999001351 Zn binding site [ion binding]; other site 648999001352 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 648999001353 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999001354 phosphate binding site [ion binding]; other site 648999001355 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 648999001356 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999001357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 648999001358 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 648999001359 active site 648999001360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999001361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999001362 DNA binding residues [nucleotide binding] 648999001363 dimerization interface [polypeptide binding]; other site 648999001364 Transcription factor WhiB; Region: Whib; pfam02467 648999001365 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 648999001366 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 648999001367 Moco binding site; other site 648999001368 metal coordination site [ion binding]; other site 648999001369 dimerization interface [polypeptide binding]; other site 648999001370 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 648999001371 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 648999001372 ring oligomerisation interface [polypeptide binding]; other site 648999001373 ATP/Mg binding site [chemical binding]; other site 648999001374 stacking interactions; other site 648999001375 hinge regions; other site 648999001376 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 648999001377 oligomerisation interface [polypeptide binding]; other site 648999001378 mobile loop; other site 648999001379 roof hairpin; other site 648999001380 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 648999001381 putative deacylase active site [active] 648999001382 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 648999001383 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 648999001384 putative ligand binding site [chemical binding]; other site 648999001385 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 648999001386 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999001387 Walker A/P-loop; other site 648999001388 ATP binding site [chemical binding]; other site 648999001389 Q-loop/lid; other site 648999001390 ABC transporter signature motif; other site 648999001391 Walker B; other site 648999001392 D-loop; other site 648999001393 H-loop/switch region; other site 648999001394 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 648999001395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999001396 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999001397 TM-ABC transporter signature motif; other site 648999001398 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999001399 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999001400 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 648999001401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 648999001402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999001403 Walker A/P-loop; other site 648999001404 ATP binding site [chemical binding]; other site 648999001405 Q-loop/lid; other site 648999001406 ABC transporter signature motif; other site 648999001407 Walker B; other site 648999001408 D-loop; other site 648999001409 H-loop/switch region; other site 648999001410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 648999001411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999001412 Walker A/P-loop; other site 648999001413 ATP binding site [chemical binding]; other site 648999001414 Q-loop/lid; other site 648999001415 ABC transporter signature motif; other site 648999001416 Walker B; other site 648999001417 D-loop; other site 648999001418 H-loop/switch region; other site 648999001419 UGMP family protein; Validated; Region: PRK09604 648999001420 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 648999001421 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 648999001422 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 648999001423 Glycoprotease family; Region: Peptidase_M22; pfam00814 648999001424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999001425 non-specific DNA binding site [nucleotide binding]; other site 648999001426 salt bridge; other site 648999001427 sequence-specific DNA binding site [nucleotide binding]; other site 648999001428 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 648999001429 ligand binding site [chemical binding]; other site 648999001430 active site 648999001431 UGI interface [polypeptide binding]; other site 648999001432 catalytic site [active] 648999001433 Secretory lipase; Region: LIP; pfam03583 648999001434 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 648999001435 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999001436 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 648999001437 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 648999001438 alanine racemase; Reviewed; Region: alr; PRK00053 648999001439 active site 648999001440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999001441 dimer interface [polypeptide binding]; other site 648999001442 substrate binding site [chemical binding]; other site 648999001443 catalytic residues [active] 648999001444 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 648999001445 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 648999001446 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 648999001447 putative substrate binding site [chemical binding]; other site 648999001448 putative ATP binding site [chemical binding]; other site 648999001449 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 648999001450 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 648999001451 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 648999001452 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 648999001453 glutaminase active site [active] 648999001454 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 648999001455 dimer interface [polypeptide binding]; other site 648999001456 active site 648999001457 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 648999001458 dimer interface [polypeptide binding]; other site 648999001459 active site 648999001460 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 648999001461 aminotransferase; Validated; Region: PRK07777 648999001462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999001463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999001464 homodimer interface [polypeptide binding]; other site 648999001465 catalytic residue [active] 648999001466 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 648999001467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999001468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999001469 catalytic residue [active] 648999001470 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 648999001471 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 648999001472 active site 648999001473 substrate binding site [chemical binding]; other site 648999001474 metal binding site [ion binding]; metal-binding site 648999001475 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 648999001476 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 648999001477 23S rRNA interface [nucleotide binding]; other site 648999001478 L3 interface [polypeptide binding]; other site 648999001479 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 648999001480 PemK-like protein; Region: PemK; cl00995 648999001481 DNA binding domain, excisionase family; Region: excise; TIGR01764 648999001482 PIN domain; Region: PIN_3; pfam13470 648999001483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999001484 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 648999001485 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 648999001486 [4Fe-4S] binding site [ion binding]; other site 648999001487 molybdopterin cofactor binding site; other site 648999001488 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 648999001489 molybdopterin cofactor binding site; other site 648999001490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 648999001491 nitrite reductase subunit NirD; Provisional; Region: PRK14989 648999001492 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 648999001493 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 648999001494 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 648999001495 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 648999001496 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 648999001497 active site 648999001498 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999001499 DNA binding site [nucleotide binding] 648999001500 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 648999001501 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 648999001502 G1 box; other site 648999001503 GTP/Mg2+ binding site [chemical binding]; other site 648999001504 G2 box; other site 648999001505 Switch I region; other site 648999001506 G3 box; other site 648999001507 Switch II region; other site 648999001508 G4 box; other site 648999001509 G5 box; other site 648999001510 Protein of unknown function (DUF742); Region: DUF742; pfam05331 648999001511 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 648999001512 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999001513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999001514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999001515 ATP binding site [chemical binding]; other site 648999001516 Mg2+ binding site [ion binding]; other site 648999001517 G-X-G motif; other site 648999001518 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 648999001519 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999001520 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 648999001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999001522 dimer interface [polypeptide binding]; other site 648999001523 conserved gate region; other site 648999001524 putative PBP binding loops; other site 648999001525 ABC-ATPase subunit interface; other site 648999001526 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 648999001527 NMT1/THI5 like; Region: NMT1; pfam09084 648999001528 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 648999001529 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 648999001530 Walker A/P-loop; other site 648999001531 ATP binding site [chemical binding]; other site 648999001532 Q-loop/lid; other site 648999001533 ABC transporter signature motif; other site 648999001534 Walker B; other site 648999001535 D-loop; other site 648999001536 H-loop/switch region; other site 648999001537 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 648999001538 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999001539 Cupin domain; Region: Cupin_2; cl17218 648999001540 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 648999001541 ThiC-associated domain; Region: ThiC-associated; pfam13667 648999001542 ThiC family; Region: ThiC; pfam01964 648999001543 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 648999001544 active site 648999001545 thiamine phosphate binding site [chemical binding]; other site 648999001546 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 648999001547 dimer interface [polypeptide binding]; other site 648999001548 substrate binding site [chemical binding]; other site 648999001549 ATP binding site [chemical binding]; other site 648999001550 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 648999001551 ThiS interaction site; other site 648999001552 putative active site [active] 648999001553 tetramer interface [polypeptide binding]; other site 648999001554 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 648999001555 thiS-thiF/thiG interaction site; other site 648999001556 hydroxyglutarate oxidase; Provisional; Region: PRK11728 648999001557 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 648999001558 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 648999001559 thiamine phosphate binding site [chemical binding]; other site 648999001560 active site 648999001561 pyrophosphate binding site [ion binding]; other site 648999001562 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 648999001563 putative active site [active] 648999001564 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999001565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999001566 active site 648999001567 catalytic tetrad [active] 648999001568 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 648999001569 active site 648999001570 NTP binding site [chemical binding]; other site 648999001571 metal binding triad [ion binding]; metal-binding site 648999001572 antibiotic binding site [chemical binding]; other site 648999001573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 648999001574 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999001575 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999001576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999001577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999001578 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 648999001579 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 648999001580 active site 648999001581 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 648999001582 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 648999001583 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 648999001584 alphaNTD homodimer interface [polypeptide binding]; other site 648999001585 alphaNTD - beta interaction site [polypeptide binding]; other site 648999001586 alphaNTD - beta' interaction site [polypeptide binding]; other site 648999001587 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 648999001588 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 648999001589 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 648999001590 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 648999001591 RNA binding surface [nucleotide binding]; other site 648999001592 30S ribosomal protein S11; Validated; Region: PRK05309 648999001593 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 648999001594 30S ribosomal protein S13; Region: bact_S13; TIGR03631 648999001595 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 648999001596 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 648999001597 rRNA binding site [nucleotide binding]; other site 648999001598 predicted 30S ribosome binding site; other site 648999001599 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 648999001600 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 648999001601 active site 648999001602 adenylate kinase; Reviewed; Region: adk; PRK00279 648999001603 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 648999001604 AMP-binding site [chemical binding]; other site 648999001605 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 648999001606 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 648999001607 SecY translocase; Region: SecY; pfam00344 648999001608 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 648999001609 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 648999001610 23S rRNA binding site [nucleotide binding]; other site 648999001611 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 648999001612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 648999001613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 648999001614 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 648999001615 5S rRNA interface [nucleotide binding]; other site 648999001616 L27 interface [polypeptide binding]; other site 648999001617 23S rRNA interface [nucleotide binding]; other site 648999001618 L5 interface [polypeptide binding]; other site 648999001619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 648999001620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 648999001621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 648999001622 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 648999001623 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 648999001624 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 648999001625 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 648999001626 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 648999001627 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 648999001628 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 648999001629 RNA binding site [nucleotide binding]; other site 648999001630 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 648999001631 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 648999001632 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 648999001633 putative translocon interaction site; other site 648999001634 signal recognition particle (SRP54) interaction site; other site 648999001635 L23 interface [polypeptide binding]; other site 648999001636 trigger factor interaction site; other site 648999001637 23S rRNA interface [nucleotide binding]; other site 648999001638 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 648999001639 23S rRNA interface [nucleotide binding]; other site 648999001640 5S rRNA interface [nucleotide binding]; other site 648999001641 putative antibiotic binding site [chemical binding]; other site 648999001642 L25 interface [polypeptide binding]; other site 648999001643 L27 interface [polypeptide binding]; other site 648999001644 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 648999001645 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 648999001646 G-X-X-G motif; other site 648999001647 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 648999001648 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 648999001649 putative translocon binding site; other site 648999001650 protein-rRNA interface [nucleotide binding]; other site 648999001651 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 648999001652 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 648999001653 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 648999001654 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 648999001655 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 648999001656 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 648999001657 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 648999001658 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 648999001659 elongation factor Tu; Reviewed; Region: PRK00049 648999001660 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 648999001661 G1 box; other site 648999001662 GEF interaction site [polypeptide binding]; other site 648999001663 GTP/Mg2+ binding site [chemical binding]; other site 648999001664 Switch I region; other site 648999001665 G2 box; other site 648999001666 G3 box; other site 648999001667 Switch II region; other site 648999001668 G4 box; other site 648999001669 G5 box; other site 648999001670 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 648999001671 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 648999001672 Antibiotic Binding Site [chemical binding]; other site 648999001673 elongation factor G; Reviewed; Region: PRK00007 648999001674 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 648999001675 G1 box; other site 648999001676 putative GEF interaction site [polypeptide binding]; other site 648999001677 GTP/Mg2+ binding site [chemical binding]; other site 648999001678 Switch I region; other site 648999001679 G2 box; other site 648999001680 G3 box; other site 648999001681 Switch II region; other site 648999001682 G4 box; other site 648999001683 G5 box; other site 648999001684 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 648999001685 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 648999001686 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 648999001687 30S ribosomal protein S7; Validated; Region: PRK05302 648999001688 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 648999001689 S17 interaction site [polypeptide binding]; other site 648999001690 S8 interaction site; other site 648999001691 16S rRNA interaction site [nucleotide binding]; other site 648999001692 streptomycin interaction site [chemical binding]; other site 648999001693 23S rRNA interaction site [nucleotide binding]; other site 648999001694 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 648999001695 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 648999001696 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 648999001697 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 648999001698 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 648999001699 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 648999001700 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 648999001701 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 648999001702 G-loop; other site 648999001703 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 648999001704 DNA binding site [nucleotide binding] 648999001705 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 648999001706 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 648999001707 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 648999001708 RPB12 interaction site [polypeptide binding]; other site 648999001709 RPB1 interaction site [polypeptide binding]; other site 648999001710 RPB10 interaction site [polypeptide binding]; other site 648999001711 RPB11 interaction site [polypeptide binding]; other site 648999001712 RPB3 interaction site [polypeptide binding]; other site 648999001713 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 648999001714 core dimer interface [polypeptide binding]; other site 648999001715 peripheral dimer interface [polypeptide binding]; other site 648999001716 L10 interface [polypeptide binding]; other site 648999001717 L11 interface [polypeptide binding]; other site 648999001718 putative EF-Tu interaction site [polypeptide binding]; other site 648999001719 putative EF-G interaction site [polypeptide binding]; other site 648999001720 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 648999001721 23S rRNA interface [nucleotide binding]; other site 648999001722 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 648999001723 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 648999001724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999001725 Walker A/P-loop; other site 648999001726 ATP binding site [chemical binding]; other site 648999001727 Q-loop/lid; other site 648999001728 ABC transporter signature motif; other site 648999001729 Walker B; other site 648999001730 D-loop; other site 648999001731 H-loop/switch region; other site 648999001732 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 648999001733 mRNA/rRNA interface [nucleotide binding]; other site 648999001734 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 648999001735 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 648999001736 23S rRNA interface [nucleotide binding]; other site 648999001737 L7/L12 interface [polypeptide binding]; other site 648999001738 putative thiostrepton binding site; other site 648999001739 L25 interface [polypeptide binding]; other site 648999001740 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 648999001741 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 648999001742 putative homodimer interface [polypeptide binding]; other site 648999001743 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 648999001744 heterodimer interface [polypeptide binding]; other site 648999001745 homodimer interface [polypeptide binding]; other site 648999001746 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 648999001747 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 648999001748 active site 648999001749 catalytic site [active] 648999001750 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 648999001751 active site 648999001752 catalytic site [active] 648999001753 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 648999001754 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999001755 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 648999001756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999001757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999001758 metal binding site [ion binding]; metal-binding site 648999001759 active site 648999001760 I-site; other site 648999001761 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999001762 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999001763 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 648999001764 active site 648999001765 catalytic residues [active] 648999001766 DNA binding site [nucleotide binding] 648999001767 Int/Topo IB signature motif; other site 648999001768 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999001769 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999001770 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 648999001771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999001772 active site 648999001773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999001774 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999001775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999001776 DNA-binding site [nucleotide binding]; DNA binding site 648999001777 UTRA domain; Region: UTRA; pfam07702 648999001778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999001779 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999001780 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 648999001781 Divergent AAA domain; Region: AAA_4; pfam04326 648999001782 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 648999001783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999001784 putative DNA binding site [nucleotide binding]; other site 648999001785 putative Zn2+ binding site [ion binding]; other site 648999001786 Transposase, Mutator family; Region: Transposase_mut; pfam00872 648999001787 MULE transposase domain; Region: MULE; pfam10551 648999001788 Abortive infection C-terminus; Region: Abi_C; pfam14355 648999001789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 648999001790 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 648999001791 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999001792 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999001793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999001794 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999001795 DNA binding residues [nucleotide binding] 648999001796 heat shock protein HtpX; Provisional; Region: PRK03072 648999001797 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999001798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999001799 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999001800 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 648999001801 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 648999001802 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 648999001803 4Fe-4S binding domain; Region: Fer4; pfam00037 648999001804 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 648999001805 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 648999001806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999001807 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 648999001808 putative dimer interface [polypeptide binding]; other site 648999001809 N-terminal domain interface [polypeptide binding]; other site 648999001810 putative substrate binding pocket (H-site) [chemical binding]; other site 648999001811 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999001812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999001813 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999001814 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999001815 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 648999001816 active site 648999001817 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 648999001818 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 648999001819 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 648999001820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999001821 ATP binding site [chemical binding]; other site 648999001822 putative Mg++ binding site [ion binding]; other site 648999001823 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999001824 nucleotide binding region [chemical binding]; other site 648999001825 ATP-binding site [chemical binding]; other site 648999001826 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999001827 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 648999001828 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 648999001829 WYL domain; Region: WYL; pfam13280 648999001830 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 648999001831 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999001832 DNA-binding site [nucleotide binding]; DNA binding site 648999001833 RNA-binding motif; other site 648999001834 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 648999001835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999001836 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999001837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999001838 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 648999001839 putative NAD(P) binding site [chemical binding]; other site 648999001840 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 648999001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999001842 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 648999001843 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 648999001844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999001845 MarR family; Region: MarR; pfam01047 648999001846 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999001847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999001848 putative substrate translocation pore; other site 648999001849 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 648999001850 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 648999001851 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 648999001852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999001853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999001854 active site 648999001855 catalytic tetrad [active] 648999001856 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 648999001857 phosphoserine aminotransferase; Provisional; Region: PRK03080 648999001858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999001859 catalytic residue [active] 648999001860 citrate synthase 2; Provisional; Region: PRK12350 648999001861 Citrate synthase; Region: Citrate_synt; pfam00285 648999001862 oxalacetate binding site [chemical binding]; other site 648999001863 citrylCoA binding site [chemical binding]; other site 648999001864 coenzyme A binding site [chemical binding]; other site 648999001865 catalytic triad [active] 648999001866 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 648999001867 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999001868 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 648999001869 enterobactin exporter EntS; Provisional; Region: PRK10489 648999001870 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 648999001871 active site 648999001872 catalytic residues [active] 648999001873 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 648999001874 putative FMN binding site [chemical binding]; other site 648999001875 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 648999001876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999001877 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999001878 active site 648999001879 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 648999001880 PspC domain; Region: PspC; pfam04024 648999001881 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 648999001882 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 648999001883 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 648999001884 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 648999001885 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999001886 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 648999001887 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 648999001888 Walker A/P-loop; other site 648999001889 ATP binding site [chemical binding]; other site 648999001890 Q-loop/lid; other site 648999001891 ABC transporter signature motif; other site 648999001892 Walker B; other site 648999001893 D-loop; other site 648999001894 H-loop/switch region; other site 648999001895 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 648999001896 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 648999001897 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999001898 active site 648999001899 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 648999001900 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 648999001901 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 648999001902 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 648999001903 Walker A/P-loop; other site 648999001904 ATP binding site [chemical binding]; other site 648999001905 Q-loop/lid; other site 648999001906 ABC transporter signature motif; other site 648999001907 Walker B; other site 648999001908 D-loop; other site 648999001909 H-loop/switch region; other site 648999001910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999001911 non-specific DNA binding site [nucleotide binding]; other site 648999001912 salt bridge; other site 648999001913 sequence-specific DNA binding site [nucleotide binding]; other site 648999001914 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999001915 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999001916 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 648999001917 Phosphotransferase enzyme family; Region: APH; pfam01636 648999001918 putative active site [active] 648999001919 putative substrate binding site [chemical binding]; other site 648999001920 ATP binding site [chemical binding]; other site 648999001921 DDE superfamily endonuclease; Region: DDE_5; cl17874 648999001922 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 648999001923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999001924 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 648999001925 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 648999001926 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 648999001927 NAD binding site [chemical binding]; other site 648999001928 catalytic Zn binding site [ion binding]; other site 648999001929 structural Zn binding site [ion binding]; other site 648999001930 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999001931 active site 648999001932 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999001933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999001934 DNA-binding site [nucleotide binding]; DNA binding site 648999001935 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 648999001936 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999001937 Walker A/P-loop; other site 648999001938 ATP binding site [chemical binding]; other site 648999001939 Q-loop/lid; other site 648999001940 ABC transporter signature motif; other site 648999001941 Walker B; other site 648999001942 D-loop; other site 648999001943 H-loop/switch region; other site 648999001944 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 648999001945 CoenzymeA binding site [chemical binding]; other site 648999001946 subunit interaction site [polypeptide binding]; other site 648999001947 PHB binding site; other site 648999001948 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 648999001949 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 648999001950 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 648999001951 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 648999001952 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 648999001953 catalytic residues [active] 648999001954 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 648999001955 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 648999001956 DNA binding residues [nucleotide binding] 648999001957 putative dimer interface [polypeptide binding]; other site 648999001958 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999001959 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 648999001960 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 648999001961 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999001962 putative active site [active] 648999001963 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999001964 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 648999001965 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 648999001966 Protein of unknown function (DUF690); Region: DUF690; cl04939 648999001967 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 648999001968 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 648999001969 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 648999001970 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 648999001971 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999001972 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 648999001973 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999001974 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999001975 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 648999001976 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 648999001977 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 648999001978 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999001979 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 648999001980 active site 648999001981 catalytic residues [active] 648999001982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999001983 MarR family; Region: MarR_2; pfam12802 648999001984 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 648999001985 active site clefts [active] 648999001986 zinc binding site [ion binding]; other site 648999001987 dimer interface [polypeptide binding]; other site 648999001988 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 648999001989 YibE/F-like protein; Region: YibE_F; pfam07907 648999001990 Short C-terminal domain; Region: SHOCT; pfam09851 648999001991 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 648999001992 putative homodimer interface [polypeptide binding]; other site 648999001993 putative homotetramer interface [polypeptide binding]; other site 648999001994 putative allosteric switch controlling residues; other site 648999001995 putative metal binding site [ion binding]; other site 648999001996 putative homodimer-homodimer interface [polypeptide binding]; other site 648999001997 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 648999001998 metal-binding site [ion binding] 648999001999 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 648999002000 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 648999002001 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 648999002002 metal-binding site [ion binding] 648999002003 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999002004 CsbD-like; Region: CsbD; pfam05532 648999002005 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 648999002006 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 648999002007 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999002008 DNA binding residues [nucleotide binding] 648999002009 YCII-related domain; Region: YCII; cl00999 648999002010 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 648999002011 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 648999002012 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999002013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999002014 S-adenosylmethionine binding site [chemical binding]; other site 648999002015 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999002016 GAF domain; Region: GAF; cl17456 648999002017 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 648999002018 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999002019 anti sigma factor interaction site; other site 648999002020 regulatory phosphorylation site [posttranslational modification]; other site 648999002021 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 648999002022 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 648999002023 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 648999002024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999002025 Soluble P-type ATPase [General function prediction only]; Region: COG4087 648999002026 K+-transporting ATPase, c chain; Region: KdpC; cl00944 648999002027 K+-transporting ATPase, c chain; Region: KdpC; cl00944 648999002028 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 648999002029 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 648999002030 Ligand Binding Site [chemical binding]; other site 648999002031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999002032 dimer interface [polypeptide binding]; other site 648999002033 phosphorylation site [posttranslational modification] 648999002034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999002035 ATP binding site [chemical binding]; other site 648999002036 Mg2+ binding site [ion binding]; other site 648999002037 G-X-G motif; other site 648999002038 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999002039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999002040 active site 648999002041 phosphorylation site [posttranslational modification] 648999002042 intermolecular recognition site; other site 648999002043 dimerization interface [polypeptide binding]; other site 648999002044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999002045 DNA binding site [nucleotide binding] 648999002046 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 648999002047 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 648999002048 oligomer interface [polypeptide binding]; other site 648999002049 metal binding site [ion binding]; metal-binding site 648999002050 metal binding site [ion binding]; metal-binding site 648999002051 putative Cl binding site [ion binding]; other site 648999002052 basic sphincter; other site 648999002053 hydrophobic gate; other site 648999002054 periplasmic entrance; other site 648999002055 Ion transport protein; Region: Ion_trans; pfam00520 648999002056 Predicted membrane protein [Function unknown]; Region: COG2261 648999002057 conserved hypothetical protein; Region: TIGR02231 648999002058 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 648999002059 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 648999002060 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 648999002061 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999002062 anti sigma factor interaction site; other site 648999002063 regulatory phosphorylation site [posttranslational modification]; other site 648999002064 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999002065 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 648999002066 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 648999002067 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999002069 dimer interface [polypeptide binding]; other site 648999002070 conserved gate region; other site 648999002071 putative PBP binding loops; other site 648999002072 ABC-ATPase subunit interface; other site 648999002073 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999002074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999002075 dimer interface [polypeptide binding]; other site 648999002076 conserved gate region; other site 648999002077 putative PBP binding loops; other site 648999002078 ABC-ATPase subunit interface; other site 648999002079 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999002080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999002081 Walker A/P-loop; other site 648999002082 ATP binding site [chemical binding]; other site 648999002083 Q-loop/lid; other site 648999002084 ABC transporter signature motif; other site 648999002085 Walker B; other site 648999002086 D-loop; other site 648999002087 H-loop/switch region; other site 648999002088 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999002089 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999002090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999002091 Walker A/P-loop; other site 648999002092 ATP binding site [chemical binding]; other site 648999002093 Q-loop/lid; other site 648999002094 ABC transporter signature motif; other site 648999002095 Walker B; other site 648999002096 D-loop; other site 648999002097 H-loop/switch region; other site 648999002098 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 648999002099 cleavage site 648999002100 active site 648999002101 substrate binding sites [chemical binding]; other site 648999002102 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999002103 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999002104 Bacterial SH3 domain; Region: SH3_3; cl17532 648999002105 TspO/MBR family; Region: TspO_MBR; pfam03073 648999002106 short chain dehydrogenase; Provisional; Region: PRK06197 648999002107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002108 NAD(P) binding site [chemical binding]; other site 648999002109 active site 648999002110 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999002111 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 648999002112 PAS fold; Region: PAS_4; pfam08448 648999002113 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999002114 GAF domain; Region: GAF; pfam01590 648999002115 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 648999002116 CBD_II domain; Region: CBD_II; smart00637 648999002117 SpoOM protein; Region: Spo0M; pfam07070 648999002118 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 648999002119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999002120 DNA binding residues [nucleotide binding] 648999002121 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999002122 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999002123 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999002124 ATP binding site [chemical binding]; other site 648999002125 Mg2+ binding site [ion binding]; other site 648999002126 G-X-G motif; other site 648999002127 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999002128 anti sigma factor interaction site; other site 648999002129 regulatory phosphorylation site [posttranslational modification]; other site 648999002130 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999002131 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999002132 DNA-binding site [nucleotide binding]; DNA binding site 648999002133 RNA-binding motif; other site 648999002134 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 648999002135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999002136 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999002137 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 648999002138 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 648999002139 DNA binding residues [nucleotide binding] 648999002140 high affinity sulphate transporter 1; Region: sulP; TIGR00815 648999002141 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 648999002142 Sulfate transporter family; Region: Sulfate_transp; pfam00916 648999002143 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 648999002144 CAAX protease self-immunity; Region: Abi; pfam02517 648999002145 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 648999002146 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 648999002147 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 648999002148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999002149 active site 648999002150 motif I; other site 648999002151 motif II; other site 648999002152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999002153 S-adenosylmethionine binding site [chemical binding]; other site 648999002154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 648999002155 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 648999002156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999002157 motif II; other site 648999002158 Thioesterase domain; Region: Thioesterase; pfam00975 648999002159 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999002160 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999002161 acyl-activating enzyme (AAE) consensus motif; other site 648999002162 AMP binding site [chemical binding]; other site 648999002163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999002164 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999002165 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999002166 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999002167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002168 Walker A/P-loop; other site 648999002169 ATP binding site [chemical binding]; other site 648999002170 Q-loop/lid; other site 648999002171 ABC transporter signature motif; other site 648999002172 Walker B; other site 648999002173 D-loop; other site 648999002174 H-loop/switch region; other site 648999002175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999002176 FeS/SAM binding site; other site 648999002177 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 648999002178 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999002179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999002180 active site 648999002181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999002182 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 648999002183 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 648999002184 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 648999002185 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999002186 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999002187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999002188 S-adenosylmethionine binding site [chemical binding]; other site 648999002189 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 648999002190 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999002191 acyl-activating enzyme (AAE) consensus motif; other site 648999002192 AMP binding site [chemical binding]; other site 648999002193 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 648999002194 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999002195 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 648999002196 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999002197 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999002198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999002199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002200 NAD(P) binding site [chemical binding]; other site 648999002201 active site 648999002202 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 648999002203 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 648999002204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999002205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999002206 catalytic residue [active] 648999002207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999002208 active site 648999002209 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999002210 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999002211 Phosphotransferase enzyme family; Region: APH; pfam01636 648999002212 active site 648999002213 ATP binding site [chemical binding]; other site 648999002214 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999002215 substrate binding site [chemical binding]; other site 648999002216 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999002217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999002218 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999002219 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 648999002220 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 648999002221 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 648999002222 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 648999002223 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 648999002224 polymerase nucleotide-binding site; other site 648999002225 DNA-binding residues [nucleotide binding]; DNA binding site 648999002226 nucleotide binding site [chemical binding]; other site 648999002227 primase nucleotide-binding site [nucleotide binding]; other site 648999002228 AAA domain; Region: AAA_25; pfam13481 648999002229 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 648999002230 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 648999002231 catalytic residues [active] 648999002232 catalytic nucleophile [active] 648999002233 Presynaptic Site I dimer interface [polypeptide binding]; other site 648999002234 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 648999002235 Synaptic Flat tetramer interface [polypeptide binding]; other site 648999002236 Synaptic Site I dimer interface [polypeptide binding]; other site 648999002237 DNA binding site [nucleotide binding] 648999002238 Recombinase; Region: Recombinase; pfam07508 648999002239 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 648999002240 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999002241 active site 648999002242 DNA binding site [nucleotide binding] 648999002243 Int/Topo IB signature motif; other site 648999002244 SprT-like family; Region: SprT-like; pfam10263 648999002245 SprT homologues; Region: SprT; cl01182 648999002246 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999002247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999002248 DNA-binding site [nucleotide binding]; DNA binding site 648999002249 Eukaryotic phosphomannomutase; Region: PMM; cl17107 648999002250 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 648999002251 Clp protease; Region: CLP_protease; pfam00574 648999002252 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 648999002253 oligomer interface [polypeptide binding]; other site 648999002254 active site residues [active] 648999002255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999002256 sequence-specific DNA binding site [nucleotide binding]; other site 648999002257 salt bridge; other site 648999002258 Ion channel; Region: Ion_trans_2; pfam07885 648999002259 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 648999002260 TrkA-N domain; Region: TrkA_N; pfam02254 648999002261 MarR family; Region: MarR_2; pfam12802 648999002262 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 648999002263 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 648999002264 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 648999002265 TPP-binding site [chemical binding]; other site 648999002266 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 648999002267 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 648999002268 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 648999002269 dimer interface [polypeptide binding]; other site 648999002270 PYR/PP interface [polypeptide binding]; other site 648999002271 TPP binding site [chemical binding]; other site 648999002272 substrate binding site [chemical binding]; other site 648999002273 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 648999002274 dihydropteroate synthase; Region: DHPS; TIGR01496 648999002275 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 648999002276 substrate binding pocket [chemical binding]; other site 648999002277 dimer interface [polypeptide binding]; other site 648999002278 inhibitor binding site; inhibition site 648999002279 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999002280 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999002281 hydrophobic ligand binding site; other site 648999002282 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 648999002283 enoyl-CoA hydratase; Provisional; Region: PRK08140 648999002284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999002285 substrate binding site [chemical binding]; other site 648999002286 oxyanion hole (OAH) forming residues; other site 648999002287 trimer interface [polypeptide binding]; other site 648999002288 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 648999002289 PaaX-like protein; Region: PaaX; pfam07848 648999002290 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 648999002291 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 648999002292 multifunctional aminopeptidase A; Provisional; Region: PRK00913 648999002293 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 648999002294 interface (dimer of trimers) [polypeptide binding]; other site 648999002295 Substrate-binding/catalytic site; other site 648999002296 Zn-binding sites [ion binding]; other site 648999002297 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 648999002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999002299 S-adenosylmethionine binding site [chemical binding]; other site 648999002300 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 648999002301 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 648999002302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 648999002303 sec-independent translocase; Provisional; Region: PRK01371 648999002304 Domain of unknown function DUF59; Region: DUF59; pfam01883 648999002305 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 648999002306 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 648999002307 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 648999002308 MgtE intracellular N domain; Region: MgtE_N; smart00924 648999002309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 648999002310 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 648999002311 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 648999002312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999002313 motif II; other site 648999002314 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 648999002315 EamA-like transporter family; Region: EamA; cl17759 648999002316 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 648999002317 short chain dehydrogenase; Provisional; Region: PRK06197 648999002318 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 648999002319 putative NAD(P) binding site [chemical binding]; other site 648999002320 active site 648999002321 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 648999002322 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 648999002323 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002325 NAD(P) binding site [chemical binding]; other site 648999002326 active site 648999002327 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 648999002328 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999002329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999002330 active site 648999002331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999002332 CoA binding domain; Region: CoA_binding; cl17356 648999002333 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 648999002334 protein-splicing catalytic site; other site 648999002335 thioester formation/cholesterol transfer; other site 648999002336 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 648999002337 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 648999002338 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 648999002339 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999002340 catalytic residues [active] 648999002341 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 648999002342 putative active site [active] 648999002343 putative catalytic site [active] 648999002344 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 648999002345 Bacterial PH domain; Region: DUF304; pfam03703 648999002346 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999002347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999002348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999002349 DNA binding residues [nucleotide binding] 648999002350 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 648999002351 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 648999002352 active site 648999002353 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 648999002354 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 648999002355 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 648999002356 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 648999002357 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 648999002358 metal binding site 2 [ion binding]; metal-binding site 648999002359 putative DNA binding helix; other site 648999002360 metal binding site 1 [ion binding]; metal-binding site 648999002361 dimer interface [polypeptide binding]; other site 648999002362 structural Zn2+ binding site [ion binding]; other site 648999002363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 648999002364 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 648999002365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999002366 dimerization interface [polypeptide binding]; other site 648999002367 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999002368 GAF domain; Region: GAF; cl17456 648999002369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999002370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999002371 metal binding site [ion binding]; metal-binding site 648999002372 active site 648999002373 I-site; other site 648999002374 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 648999002375 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 648999002376 active site 648999002377 tetramer interface; other site 648999002378 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 648999002379 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 648999002380 dimer interface [polypeptide binding]; other site 648999002381 putative functional site; other site 648999002382 putative MPT binding site; other site 648999002383 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999002384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999002385 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 648999002386 active site 648999002387 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 648999002388 putative hydrophobic ligand binding site [chemical binding]; other site 648999002389 CLM binding site; other site 648999002390 L1 loop; other site 648999002391 DNA binding site [nucleotide binding] 648999002392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999002393 putative DNA binding site [nucleotide binding]; other site 648999002394 dimerization interface [polypeptide binding]; other site 648999002395 putative Zn2+ binding site [ion binding]; other site 648999002396 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 648999002397 large tegument protein UL36; Provisional; Region: PHA03247 648999002398 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999002399 hypothetical protein; Provisional; Region: PRK06834 648999002400 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999002401 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 648999002402 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 648999002403 conserved cys residue [active] 648999002404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999002405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002406 NAD(P) binding site [chemical binding]; other site 648999002407 Cellulose binding domain; Region: CBM_2; pfam00553 648999002408 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 648999002409 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 648999002410 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 648999002411 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999002412 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 648999002413 active site 648999002414 metal binding site [ion binding]; metal-binding site 648999002415 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 648999002416 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 648999002417 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 648999002418 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 648999002419 metal ion-dependent adhesion site (MIDAS); other site 648999002420 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 648999002421 Predicted methyltransferases [General function prediction only]; Region: COG0313 648999002422 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 648999002423 putative SAM binding site [chemical binding]; other site 648999002424 putative homodimer interface [polypeptide binding]; other site 648999002425 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 648999002426 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 648999002427 active site 648999002428 HIGH motif; other site 648999002429 KMSKS motif; other site 648999002430 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 648999002431 tRNA binding surface [nucleotide binding]; other site 648999002432 anticodon binding site; other site 648999002433 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999002434 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 648999002435 TAP-like protein; Region: Abhydrolase_4; pfam08386 648999002436 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 648999002437 active site 648999002438 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 648999002439 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 648999002440 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 648999002441 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 648999002442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002443 Walker A/P-loop; other site 648999002444 ATP binding site [chemical binding]; other site 648999002445 Q-loop/lid; other site 648999002446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999002447 ABC transporter; Region: ABC_tran_2; pfam12848 648999002448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999002449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999002450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999002451 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 648999002452 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 648999002453 Substrate binding site; other site 648999002454 Mg++ binding site; other site 648999002455 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 648999002456 active site 648999002457 substrate binding site [chemical binding]; other site 648999002458 CoA binding site [chemical binding]; other site 648999002459 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 648999002460 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 648999002461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999002462 active site 648999002463 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 648999002464 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 648999002465 5S rRNA interface [nucleotide binding]; other site 648999002466 CTC domain interface [polypeptide binding]; other site 648999002467 L16 interface [polypeptide binding]; other site 648999002468 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 648999002469 putative active site [active] 648999002470 catalytic residue [active] 648999002471 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999002472 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 648999002473 active site 648999002474 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 648999002475 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 648999002476 Active Sites [active] 648999002477 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 648999002478 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 648999002479 CysD dimerization site [polypeptide binding]; other site 648999002480 G1 box; other site 648999002481 putative GEF interaction site [polypeptide binding]; other site 648999002482 GTP/Mg2+ binding site [chemical binding]; other site 648999002483 Switch I region; other site 648999002484 G2 box; other site 648999002485 G3 box; other site 648999002486 Switch II region; other site 648999002487 G4 box; other site 648999002488 G5 box; other site 648999002489 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 648999002490 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 648999002491 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 648999002492 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 648999002493 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 648999002494 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 648999002495 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 648999002496 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 648999002497 NAD binding site [chemical binding]; other site 648999002498 homodimer interface [polypeptide binding]; other site 648999002499 active site 648999002500 substrate binding site [chemical binding]; other site 648999002501 FOG: CBS domain [General function prediction only]; Region: COG0517 648999002502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999002503 Transporter associated domain; Region: CorC_HlyC; smart01091 648999002504 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 648999002505 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 648999002506 active site 648999002507 HIGH motif; other site 648999002508 dimer interface [polypeptide binding]; other site 648999002509 KMSKS motif; other site 648999002510 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 648999002511 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 648999002512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999002513 DNA-binding site [nucleotide binding]; DNA binding site 648999002514 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 648999002515 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 648999002516 active site 648999002517 catalytic site [active] 648999002518 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 648999002519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999002520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999002521 DNA binding site [nucleotide binding] 648999002522 domain linker motif; other site 648999002523 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 648999002524 putative dimerization interface [polypeptide binding]; other site 648999002525 putative ligand binding site [chemical binding]; other site 648999002526 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 648999002527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999002528 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 648999002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999002530 dimer interface [polypeptide binding]; other site 648999002531 conserved gate region; other site 648999002532 putative PBP binding loops; other site 648999002533 ABC-ATPase subunit interface; other site 648999002534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999002536 dimer interface [polypeptide binding]; other site 648999002537 conserved gate region; other site 648999002538 putative PBP binding loops; other site 648999002539 ABC-ATPase subunit interface; other site 648999002540 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 648999002541 homodimer interface [polypeptide binding]; other site 648999002542 maltodextrin glucosidase; Provisional; Region: PRK10785 648999002543 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 648999002544 active site 648999002545 homodimer interface [polypeptide binding]; other site 648999002546 catalytic site [active] 648999002547 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 648999002548 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 648999002549 ligand binding site [chemical binding]; other site 648999002550 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 648999002551 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999002552 Walker A/P-loop; other site 648999002553 ATP binding site [chemical binding]; other site 648999002554 Q-loop/lid; other site 648999002555 ABC transporter signature motif; other site 648999002556 Walker B; other site 648999002557 D-loop; other site 648999002558 H-loop/switch region; other site 648999002559 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 648999002560 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999002561 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 648999002562 TM-ABC transporter signature motif; other site 648999002563 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999002564 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 648999002565 TM-ABC transporter signature motif; other site 648999002566 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 648999002567 active site 648999002568 catalytic motif [active] 648999002569 Zn binding site [ion binding]; other site 648999002570 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 648999002571 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 648999002572 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 648999002573 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 648999002574 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 648999002575 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 648999002576 MarR family; Region: MarR_2; pfam12802 648999002577 Predicted membrane protein [Function unknown]; Region: COG2364 648999002578 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 648999002579 Predicted flavoprotein [General function prediction only]; Region: COG0431 648999002580 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999002581 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 648999002582 adenosine deaminase; Provisional; Region: PRK09358 648999002583 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 648999002584 active site 648999002585 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999002586 active site 648999002587 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 648999002588 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999002589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999002590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999002591 ATP binding site [chemical binding]; other site 648999002592 Mg2+ binding site [ion binding]; other site 648999002593 G-X-G motif; other site 648999002594 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 648999002595 Protein of unknown function (DUF742); Region: DUF742; pfam05331 648999002596 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 648999002597 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 648999002598 G1 box; other site 648999002599 GTP/Mg2+ binding site [chemical binding]; other site 648999002600 G2 box; other site 648999002601 Switch I region; other site 648999002602 G3 box; other site 648999002603 Switch II region; other site 648999002604 G4 box; other site 648999002605 G5 box; other site 648999002606 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 648999002607 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999002608 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999002609 Transcriptional regulator PadR-like family; Region: PadR; cl17335 648999002610 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999002611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002612 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999002613 Walker A/P-loop; other site 648999002614 ATP binding site [chemical binding]; other site 648999002615 Q-loop/lid; other site 648999002616 ABC transporter signature motif; other site 648999002617 Walker B; other site 648999002618 D-loop; other site 648999002619 H-loop/switch region; other site 648999002620 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 648999002621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999002622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002623 Walker A/P-loop; other site 648999002624 ATP binding site [chemical binding]; other site 648999002625 Q-loop/lid; other site 648999002626 ABC transporter signature motif; other site 648999002627 Walker B; other site 648999002628 D-loop; other site 648999002629 H-loop/switch region; other site 648999002630 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 648999002631 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 648999002632 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 648999002633 Peptidase family M48; Region: Peptidase_M48; cl12018 648999002634 Penicillinase repressor; Region: Pencillinase_R; pfam03965 648999002635 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999002636 NAD(P) binding site [chemical binding]; other site 648999002637 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 648999002638 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999002639 NAD(P) binding site [chemical binding]; other site 648999002640 catalytic residues [active] 648999002641 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 648999002642 intersubunit interface [polypeptide binding]; other site 648999002643 active site 648999002644 catalytic residue [active] 648999002645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999002646 active site 648999002647 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 648999002648 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 648999002649 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 648999002650 active site 648999002651 substrate binding site [chemical binding]; other site 648999002652 metal binding site [ion binding]; metal-binding site 648999002653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999002654 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 648999002655 active site 648999002656 ATP binding site [chemical binding]; other site 648999002657 substrate binding site [chemical binding]; other site 648999002658 activation loop (A-loop); other site 648999002659 PsbP; Region: PsbP; cl03356 648999002660 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 648999002661 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 648999002662 amidohydrolase; Region: amidohydrolases; TIGR01891 648999002663 metal binding site [ion binding]; metal-binding site 648999002664 putative dimer interface [polypeptide binding]; other site 648999002665 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 648999002666 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999002667 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 648999002668 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 648999002669 putative active site pocket [active] 648999002670 dimerization interface [polypeptide binding]; other site 648999002671 putative catalytic residue [active] 648999002672 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 648999002673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999002674 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999002675 Protein of unknown function (DUF998); Region: DUF998; pfam06197 648999002676 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999002677 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 648999002678 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 648999002679 active site 648999002680 dimer interface [polypeptide binding]; other site 648999002681 motif 1; other site 648999002682 motif 2; other site 648999002683 motif 3; other site 648999002684 Anticodon binding domain; Region: HGTP_anticodon; pfam03129 648999002685 anticodon binding site; other site 648999002686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999002687 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 648999002688 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 648999002689 Walker A/P-loop; other site 648999002690 ATP binding site [chemical binding]; other site 648999002691 Q-loop/lid; other site 648999002692 ABC transporter signature motif; other site 648999002693 Walker B; other site 648999002694 D-loop; other site 648999002695 H-loop/switch region; other site 648999002696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 648999002697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999002698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002699 Walker A/P-loop; other site 648999002700 ATP binding site [chemical binding]; other site 648999002701 Q-loop/lid; other site 648999002702 ABC transporter signature motif; other site 648999002703 Walker B; other site 648999002704 D-loop; other site 648999002705 H-loop/switch region; other site 648999002706 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999002707 MarR family; Region: MarR_2; cl17246 648999002708 MarR family; Region: MarR; pfam01047 648999002709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999002710 putative substrate translocation pore; other site 648999002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999002712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999002713 WHG domain; Region: WHG; pfam13305 648999002714 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 648999002715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999002716 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 648999002717 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 648999002718 active site 648999002719 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 648999002720 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999002721 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 648999002722 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 648999002723 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 648999002724 carboxyltransferase (CT) interaction site; other site 648999002725 biotinylation site [posttranslational modification]; other site 648999002726 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999002727 Transcriptional regulator PadR-like family; Region: PadR; cl17335 648999002728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999002729 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999002730 Walker A/P-loop; other site 648999002731 ATP binding site [chemical binding]; other site 648999002732 Q-loop/lid; other site 648999002733 ABC transporter signature motif; other site 648999002734 Walker B; other site 648999002735 D-loop; other site 648999002736 H-loop/switch region; other site 648999002737 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 648999002738 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999002739 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 648999002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999002741 S-adenosylmethionine binding site [chemical binding]; other site 648999002742 Maf-like protein; Reviewed; Region: PRK00078 648999002743 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 648999002744 active site 648999002745 dimer interface [polypeptide binding]; other site 648999002746 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999002747 active site 648999002748 catalytic residues [active] 648999002749 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999002750 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999002751 active site 648999002752 ATP binding site [chemical binding]; other site 648999002753 substrate binding site [chemical binding]; other site 648999002754 activation loop (A-loop); other site 648999002755 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 648999002756 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 648999002757 active site 648999002758 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 648999002759 putative active site [active] 648999002760 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 648999002761 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 648999002762 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 648999002763 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 648999002764 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999002765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999002766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999002767 DNA binding residues [nucleotide binding] 648999002768 Flagellar L-ring protein; Region: FlgH; cl17277 648999002769 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 648999002770 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 648999002771 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 648999002772 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 648999002773 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 648999002774 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 648999002775 Bacterial PH domain; Region: DUF304; pfam03703 648999002776 Predicted membrane protein [Function unknown]; Region: COG2246 648999002777 GtrA-like protein; Region: GtrA; pfam04138 648999002778 Predicted membrane protein [Function unknown]; Region: COG2246 648999002779 GtrA-like protein; Region: GtrA; pfam04138 648999002780 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 648999002781 active site 648999002782 substrate-binding site [chemical binding]; other site 648999002783 metal-binding site [ion binding] 648999002784 GTP binding site [chemical binding]; other site 648999002785 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 648999002786 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 648999002787 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 648999002788 catalytic residue [active] 648999002789 putative FPP diphosphate binding site; other site 648999002790 putative FPP binding hydrophobic cleft; other site 648999002791 dimer interface [polypeptide binding]; other site 648999002792 putative IPP diphosphate binding site; other site 648999002793 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 648999002794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999002795 active site 648999002796 motif I; other site 648999002797 motif II; other site 648999002798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999002799 sequence-specific DNA binding site [nucleotide binding]; other site 648999002800 salt bridge; other site 648999002801 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 648999002802 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 648999002803 putative active site [active] 648999002804 PhoH-like protein; Region: PhoH; pfam02562 648999002805 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 648999002806 N-acetyl-D-glucosamine binding site [chemical binding]; other site 648999002807 catalytic residue [active] 648999002808 Rhomboid family; Region: Rhomboid; pfam01694 648999002809 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 648999002810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999002811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999002812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999002813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999002814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002815 NAD(P) binding site [chemical binding]; other site 648999002816 active site 648999002817 Protein of unknown function, DUF606; Region: DUF606; pfam04657 648999002818 Protein of unknown function, DUF606; Region: DUF606; pfam04657 648999002819 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 648999002820 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 648999002821 putative active site [active] 648999002822 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 648999002823 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 648999002824 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 648999002825 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 648999002826 generic binding surface II; other site 648999002827 generic binding surface I; other site 648999002828 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 648999002829 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 648999002830 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999002831 active site 648999002832 catalytic residues [active] 648999002833 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 648999002834 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 648999002835 RmuC family; Region: RmuC; pfam02646 648999002836 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 648999002837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999002838 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 648999002839 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 648999002840 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 648999002841 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 648999002842 putative dimer interface [polypeptide binding]; other site 648999002843 catalytic triad [active] 648999002844 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 648999002845 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 648999002846 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 648999002847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999002848 ATP binding site [chemical binding]; other site 648999002849 putative Mg++ binding site [ion binding]; other site 648999002850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999002851 nucleotide binding region [chemical binding]; other site 648999002852 ATP-binding site [chemical binding]; other site 648999002853 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 648999002854 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 648999002855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 648999002856 homodimer interface [polypeptide binding]; other site 648999002857 metal binding site [ion binding]; metal-binding site 648999002858 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 648999002859 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 648999002860 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 648999002861 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 648999002862 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 648999002863 putative NADH binding site [chemical binding]; other site 648999002864 putative active site [active] 648999002865 nudix motif; other site 648999002866 putative metal binding site [ion binding]; other site 648999002867 enolase; Provisional; Region: eno; PRK00077 648999002868 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 648999002869 dimer interface [polypeptide binding]; other site 648999002870 metal binding site [ion binding]; metal-binding site 648999002871 substrate binding pocket [chemical binding]; other site 648999002872 Septum formation initiator; Region: DivIC; pfam04977 648999002873 Protein of unknown function (DUF501); Region: DUF501; cl00652 648999002874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999002875 Coenzyme A binding pocket [chemical binding]; other site 648999002876 exopolyphosphatase; Region: exo_poly_only; TIGR03706 648999002877 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 648999002878 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999002879 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999002880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999002881 non-specific DNA binding site [nucleotide binding]; other site 648999002882 salt bridge; other site 648999002883 sequence-specific DNA binding site [nucleotide binding]; other site 648999002884 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 648999002885 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 648999002886 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 648999002887 Fe-S cluster binding site [ion binding]; other site 648999002888 DNA binding site [nucleotide binding] 648999002889 active site 648999002890 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 648999002891 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999002892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999002893 Walker A motif; other site 648999002894 ATP binding site [chemical binding]; other site 648999002895 Walker B motif; other site 648999002896 arginine finger; other site 648999002897 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 648999002898 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999002899 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 648999002900 Protein of unknown function (DUF1188); Region: DUF1188; cl01642 648999002901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999002902 Bax inhibitor 1 like; Region: BaxI_1; cl17691 648999002903 Bax inhibitor 1 like; Region: BaxI_1; cl17691 648999002904 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 648999002905 putative active site; other site 648999002906 putative metal binding residues [ion binding]; other site 648999002907 signature motif; other site 648999002908 putative triphosphate binding site [ion binding]; other site 648999002909 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 648999002910 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 648999002911 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999002912 dimer interface [polypeptide binding]; other site 648999002913 active site 648999002914 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 648999002915 active site 648999002916 catalytic triad [active] 648999002917 oxyanion hole [active] 648999002918 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 648999002919 active site 648999002920 catalytic triad [active] 648999002921 oxyanion hole [active] 648999002922 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 648999002923 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 648999002924 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 648999002925 dimer interface [polypeptide binding]; other site 648999002926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999002927 catalytic residue [active] 648999002928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 648999002929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999002930 Coenzyme A binding pocket [chemical binding]; other site 648999002931 ribonuclease Z; Reviewed; Region: PRK00055 648999002932 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 648999002933 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 648999002934 putative oligomer interface [polypeptide binding]; other site 648999002935 putative active site [active] 648999002936 metal binding site [ion binding]; metal-binding site 648999002937 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 648999002938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999002939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999002940 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 648999002941 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 648999002942 active site 648999002943 dimer interface [polypeptide binding]; other site 648999002944 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 648999002945 Ligand Binding Site [chemical binding]; other site 648999002946 Molecular Tunnel; other site 648999002947 methionine sulfoxide reductase A; Provisional; Region: PRK00058 648999002948 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 648999002949 nucleotide binding site/active site [active] 648999002950 HIT family signature motif; other site 648999002951 catalytic residue [active] 648999002952 cystathionine gamma-synthase; Provisional; Region: PRK07811 648999002953 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 648999002954 homodimer interface [polypeptide binding]; other site 648999002955 substrate-cofactor binding pocket; other site 648999002956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999002957 catalytic residue [active] 648999002958 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 648999002959 Amidase; Region: Amidase; cl11426 648999002960 Amidase; Region: Amidase; cl11426 648999002961 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 648999002962 threonine dehydratase; Provisional; Region: PRK08198 648999002963 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 648999002964 tetramer interface [polypeptide binding]; other site 648999002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999002966 catalytic residue [active] 648999002967 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 648999002968 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 648999002969 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 648999002970 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 648999002971 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 648999002972 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 648999002973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999002974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999002975 metal binding site [ion binding]; metal-binding site 648999002976 active site 648999002977 I-site; other site 648999002978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999002979 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 648999002980 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 648999002981 catalytic residues [active] 648999002982 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 648999002983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999002984 ATP-grasp domain; Region: ATP-grasp; pfam02222 648999002985 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 648999002986 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 648999002987 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 648999002988 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 648999002989 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 648999002990 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999002991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999002992 active site 648999002993 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 648999002994 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 648999002995 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 648999002996 acyl-activating enzyme (AAE) consensus motif; other site 648999002997 putative AMP binding site [chemical binding]; other site 648999002998 putative active site [active] 648999002999 putative CoA binding site [chemical binding]; other site 648999003000 TIGR03089 family protein; Region: TIGR03089 648999003001 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 648999003002 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 648999003003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999003004 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 648999003005 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 648999003006 Substrate binding site; other site 648999003007 Cupin domain; Region: Cupin_2; cl17218 648999003008 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 648999003009 nudix motif; other site 648999003010 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 648999003011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999003012 dimerization interface [polypeptide binding]; other site 648999003013 putative DNA binding site [nucleotide binding]; other site 648999003014 putative Zn2+ binding site [ion binding]; other site 648999003015 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 648999003016 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 648999003017 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 648999003018 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 648999003019 phosphate binding site [ion binding]; other site 648999003020 dimer interface [polypeptide binding]; other site 648999003021 substrate binding site [chemical binding]; other site 648999003022 FO synthase; Reviewed; Region: fbiC; PRK09234 648999003023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999003024 FeS/SAM binding site; other site 648999003025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999003026 FeS/SAM binding site; other site 648999003027 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 648999003028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999003029 Transcription factor WhiB; Region: Whib; pfam02467 648999003030 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 648999003031 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 648999003032 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 648999003033 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 648999003034 hypothetical protein; Provisional; Region: PRK06541 648999003035 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999003036 inhibitor-cofactor binding pocket; inhibition site 648999003037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999003038 catalytic residue [active] 648999003039 dimerization interface [polypeptide binding]; other site 648999003040 putative DNA binding site [nucleotide binding]; other site 648999003041 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 648999003042 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 648999003043 putative Zn2+ binding site [ion binding]; other site 648999003044 AsnC family; Region: AsnC_trans_reg; pfam01037 648999003045 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 648999003046 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 648999003047 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 648999003048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003049 Walker A/P-loop; other site 648999003050 ATP binding site [chemical binding]; other site 648999003051 Q-loop/lid; other site 648999003052 ABC transporter signature motif; other site 648999003053 Walker B; other site 648999003054 D-loop; other site 648999003055 H-loop/switch region; other site 648999003056 TOBE domain; Region: TOBE_2; pfam08402 648999003057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999003058 dimer interface [polypeptide binding]; other site 648999003059 conserved gate region; other site 648999003060 putative PBP binding loops; other site 648999003061 ABC-ATPase subunit interface; other site 648999003062 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 648999003063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999003064 dimer interface [polypeptide binding]; other site 648999003065 conserved gate region; other site 648999003066 ABC-ATPase subunit interface; other site 648999003067 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 648999003068 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 648999003069 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 648999003070 agmatinase; Region: agmatinase; TIGR01230 648999003071 Agmatinase-like family; Region: Agmatinase-like; cd09990 648999003072 active site 648999003073 oligomer interface [polypeptide binding]; other site 648999003074 Mn binding site [ion binding]; other site 648999003075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999003076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999003077 non-specific DNA binding site [nucleotide binding]; other site 648999003078 salt bridge; other site 648999003079 sequence-specific DNA binding site [nucleotide binding]; other site 648999003080 Protein of unknown function (DUF779); Region: DUF779; pfam05610 648999003081 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999003082 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999003083 NAD(P) binding site [chemical binding]; other site 648999003084 catalytic residues [active] 648999003085 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 648999003086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999003087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999003088 active site 648999003089 phosphorylation site [posttranslational modification] 648999003090 intermolecular recognition site; other site 648999003091 dimerization interface [polypeptide binding]; other site 648999003092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999003093 DNA binding site [nucleotide binding] 648999003094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999003095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999003096 dimerization interface [polypeptide binding]; other site 648999003097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999003098 dimer interface [polypeptide binding]; other site 648999003099 phosphorylation site [posttranslational modification] 648999003100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999003101 ATP binding site [chemical binding]; other site 648999003102 Mg2+ binding site [ion binding]; other site 648999003103 G-X-G motif; other site 648999003104 Predicted membrane protein [Function unknown]; Region: COG4763 648999003105 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 648999003106 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 648999003107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999003108 catalytic residue [active] 648999003109 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 648999003110 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 648999003111 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 648999003112 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 648999003113 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 648999003114 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999003115 inhibitor-cofactor binding pocket; inhibition site 648999003116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999003117 catalytic residue [active] 648999003118 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 648999003119 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 648999003120 tetrameric interface [polypeptide binding]; other site 648999003121 NAD binding site [chemical binding]; other site 648999003122 catalytic residues [active] 648999003123 substrate binding site [chemical binding]; other site 648999003124 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 648999003125 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999003126 NAD(P) binding site [chemical binding]; other site 648999003127 catalytic residues [active] 648999003128 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 648999003129 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 648999003130 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 648999003131 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 648999003132 metal binding triad [ion binding]; metal-binding site 648999003133 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 648999003134 Active_site [active] 648999003135 Trm112p-like protein; Region: Trm112p; cl01066 648999003136 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 648999003137 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 648999003138 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 648999003139 dimer interface [polypeptide binding]; other site 648999003140 active site 648999003141 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 648999003142 Cation efflux family; Region: Cation_efflux; pfam01545 648999003143 mannose-6-phosphate isomerase; Region: PLN02288 648999003144 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 648999003145 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 648999003146 Adenosylhomocysteinase; Provisional; Region: PTZ00075 648999003147 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 648999003148 homotetramer interface [polypeptide binding]; other site 648999003149 ligand binding site [chemical binding]; other site 648999003150 catalytic site [active] 648999003151 NAD binding site [chemical binding]; other site 648999003152 Iron permease FTR1 family; Region: FTR1; pfam03239 648999003153 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 648999003154 Imelysin; Region: Peptidase_M75; pfam09375 648999003155 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 648999003156 RDD family; Region: RDD; pfam06271 648999003157 Integral membrane protein DUF95; Region: DUF95; pfam01944 648999003158 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 648999003159 Transglutaminase family, C-terminal ig like domain; Region: Transglut_C; pfam00927 648999003160 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999003161 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999003162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999003163 Walker A motif; other site 648999003164 ATP binding site [chemical binding]; other site 648999003165 Walker B motif; other site 648999003166 arginine finger; other site 648999003167 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 648999003168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999003170 active site 648999003171 phosphorylation site [posttranslational modification] 648999003172 intermolecular recognition site; other site 648999003173 dimerization interface [polypeptide binding]; other site 648999003174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999003175 DNA binding site [nucleotide binding] 648999003176 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 648999003177 dimerization interface [polypeptide binding]; other site 648999003178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999003179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999003180 dimer interface [polypeptide binding]; other site 648999003181 phosphorylation site [posttranslational modification] 648999003182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999003183 ATP binding site [chemical binding]; other site 648999003184 Mg2+ binding site [ion binding]; other site 648999003185 G-X-G motif; other site 648999003186 lipoprotein LpqB; Provisional; Region: PRK13616 648999003187 Sporulation and spore germination; Region: Germane; pfam10646 648999003188 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 648999003189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999003190 active site 648999003191 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 648999003192 30S subunit binding site; other site 648999003193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999003194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999003195 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999003196 Coenzyme A binding pocket [chemical binding]; other site 648999003197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999003198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999003199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999003200 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 648999003201 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 648999003202 nucleotide binding region [chemical binding]; other site 648999003203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 648999003204 SEC-C motif; Region: SEC-C; pfam02810 648999003205 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999003206 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999003207 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 648999003208 NAD(P) binding site [chemical binding]; other site 648999003209 catalytic residues [active] 648999003210 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999003211 Transcriptional regulator PadR-like family; Region: PadR; cl17335 648999003212 peptide chain release factor 2; Validated; Region: prfB; PRK00578 648999003213 This domain is found in peptide chain release factors; Region: PCRF; smart00937 648999003214 RF-1 domain; Region: RF-1; pfam00472 648999003215 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 648999003216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003217 Walker A/P-loop; other site 648999003218 ATP binding site [chemical binding]; other site 648999003219 Q-loop/lid; other site 648999003220 ABC transporter signature motif; other site 648999003221 Walker B; other site 648999003222 D-loop; other site 648999003223 H-loop/switch region; other site 648999003224 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 648999003225 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 648999003226 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 648999003227 SmpB-tmRNA interface; other site 648999003228 benzoylformate decarboxylase; Reviewed; Region: PRK07092 648999003229 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 648999003230 PYR/PP interface [polypeptide binding]; other site 648999003231 dimer interface [polypeptide binding]; other site 648999003232 TPP binding site [chemical binding]; other site 648999003233 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 648999003234 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 648999003235 TPP-binding site [chemical binding]; other site 648999003236 dimer interface [polypeptide binding]; other site 648999003237 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 648999003238 hypothetical protein; Validated; Region: PRK00228 648999003239 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 648999003240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999003241 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 648999003242 putative dimer interface [polypeptide binding]; other site 648999003243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999003244 Homeodomain-like domain; Region: HTH_23; pfam13384 648999003245 Winged helix-turn helix; Region: HTH_29; pfam13551 648999003246 DDE superfamily endonuclease; Region: DDE_3; pfam13358 648999003247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 648999003248 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 648999003249 Cupin; Region: Cupin_6; pfam12852 648999003250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999003252 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999003253 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999003254 active site 648999003255 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 648999003256 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 648999003257 active site 648999003258 catalytic site [active] 648999003259 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 648999003260 Chitin binding domain; Region: Chitin_bind_3; pfam03067 648999003261 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999003262 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999003263 active site 648999003264 catalytic tetrad [active] 648999003265 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999003266 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999003267 active site 648999003268 catalytic tetrad [active] 648999003269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999003270 Histidine kinase; Region: HisKA_3; pfam07730 648999003271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999003272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999003273 active site 648999003274 phosphorylation site [posttranslational modification] 648999003275 intermolecular recognition site; other site 648999003276 dimerization interface [polypeptide binding]; other site 648999003277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999003278 dimerization interface [polypeptide binding]; other site 648999003279 DNA binding residues [nucleotide binding] 648999003280 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 648999003281 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 648999003282 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 648999003283 metal ion-dependent adhesion site (MIDAS); other site 648999003284 Transposase, Mutator family; Region: Transposase_mut; pfam00872 648999003285 MULE transposase domain; Region: MULE; pfam10551 648999003286 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 648999003287 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 648999003288 conserved cys residue [active] 648999003289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999003290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999003291 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999003292 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999003293 putative sugar binding sites [chemical binding]; other site 648999003294 Q-X-W motif; other site 648999003295 Domain of unknown function (DUF427); Region: DUF427; pfam04248 648999003296 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 648999003297 putative deacylase active site [active] 648999003298 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 648999003299 FAD binding domain; Region: FAD_binding_4; pfam01565 648999003300 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 648999003301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999003302 S-adenosylmethionine binding site [chemical binding]; other site 648999003303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999003304 dimerization interface [polypeptide binding]; other site 648999003305 putative DNA binding site [nucleotide binding]; other site 648999003306 putative Zn2+ binding site [ion binding]; other site 648999003307 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999003308 hydrophobic ligand binding site; other site 648999003309 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 648999003310 putative hydrophobic ligand binding site [chemical binding]; other site 648999003311 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 648999003312 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 648999003313 active site triad [active] 648999003314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999003315 dimerization interface [polypeptide binding]; other site 648999003316 putative DNA binding site [nucleotide binding]; other site 648999003317 putative Zn2+ binding site [ion binding]; other site 648999003318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999003319 metal binding site [ion binding]; metal-binding site 648999003320 active site 648999003321 I-site; other site 648999003322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999003323 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 648999003324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999003325 DNA binding residues [nucleotide binding] 648999003326 dimer interface [polypeptide binding]; other site 648999003327 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 648999003328 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999003329 fructuronate transporter; Provisional; Region: PRK10034; cl15264 648999003330 fructuronate transporter; Provisional; Region: PRK10034; cl15264 648999003331 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 648999003332 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 648999003333 N- and C-terminal domain interface [polypeptide binding]; other site 648999003334 active site 648999003335 catalytic site [active] 648999003336 metal binding site [ion binding]; metal-binding site 648999003337 carbohydrate binding site [chemical binding]; other site 648999003338 ATP binding site [chemical binding]; other site 648999003339 Phosphotransferase enzyme family; Region: APH; pfam01636 648999003340 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999003341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999003342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999003343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 648999003344 Haemolytic domain; Region: Haemolytic; pfam01809 648999003345 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 648999003346 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 648999003347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999003348 MMPL family; Region: MMPL; pfam03176 648999003349 MMPL family; Region: MMPL; pfam03176 648999003350 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 648999003351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999003352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999003353 active site 648999003354 phosphorylation site [posttranslational modification] 648999003355 intermolecular recognition site; other site 648999003356 dimerization interface [polypeptide binding]; other site 648999003357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999003358 DNA binding residues [nucleotide binding] 648999003359 dimerization interface [polypeptide binding]; other site 648999003360 Histidine kinase; Region: HisKA_3; pfam07730 648999003361 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999003362 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 648999003363 PLD-like domain; Region: PLDc_2; pfam13091 648999003364 putative homodimer interface [polypeptide binding]; other site 648999003365 putative active site [active] 648999003366 catalytic site [active] 648999003367 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 648999003368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999003369 ATP binding site [chemical binding]; other site 648999003370 putative Mg++ binding site [ion binding]; other site 648999003371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999003372 nucleotide binding region [chemical binding]; other site 648999003373 ATP-binding site [chemical binding]; other site 648999003374 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 648999003375 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999003376 Phosphotransferase enzyme family; Region: APH; pfam01636 648999003377 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999003378 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999003379 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999003380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999003381 S-adenosylmethionine binding site [chemical binding]; other site 648999003382 Part of AAA domain; Region: AAA_19; pfam13245 648999003383 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 648999003384 AAA domain; Region: AAA_12; pfam13087 648999003385 LabA_like proteins; Region: LabA_like; cd06167 648999003386 putative metal binding site [ion binding]; other site 648999003387 Uncharacterized conserved protein [Function unknown]; Region: COG1432 648999003388 Nuclease-related domain; Region: NERD; pfam08378 648999003389 AAA domain; Region: AAA_22; pfam13401 648999003390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 648999003391 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 648999003392 AAA ATPase domain; Region: AAA_16; pfam13191 648999003393 Walker A motif; other site 648999003394 ATP binding site [chemical binding]; other site 648999003395 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999003396 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999003397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003398 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999003399 Walker A/P-loop; other site 648999003400 ATP binding site [chemical binding]; other site 648999003401 Q-loop/lid; other site 648999003402 ABC transporter signature motif; other site 648999003403 Walker B; other site 648999003404 D-loop; other site 648999003405 H-loop/switch region; other site 648999003406 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999003407 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999003408 active site 648999003409 catalytic tetrad [active] 648999003410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999003411 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999003412 active site 648999003413 catalytic tetrad [active] 648999003414 Endonuclease I; Region: Endonuclease_1; pfam04231 648999003415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999003416 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 648999003417 substrate binding pocket [chemical binding]; other site 648999003418 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 648999003419 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999003420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 648999003421 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 648999003422 Sulfatase; Region: Sulfatase; cl17466 648999003423 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 648999003424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999003425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003426 Walker A/P-loop; other site 648999003427 ATP binding site [chemical binding]; other site 648999003428 Q-loop/lid; other site 648999003429 ABC transporter signature motif; other site 648999003430 Walker B; other site 648999003431 D-loop; other site 648999003432 H-loop/switch region; other site 648999003433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999003434 Histidine kinase; Region: HisKA_3; pfam07730 648999003435 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999003436 ATP binding site [chemical binding]; other site 648999003437 Mg2+ binding site [ion binding]; other site 648999003438 G-X-G motif; other site 648999003439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999003440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999003441 active site 648999003442 phosphorylation site [posttranslational modification] 648999003443 intermolecular recognition site; other site 648999003444 dimerization interface [polypeptide binding]; other site 648999003445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999003446 DNA binding residues [nucleotide binding] 648999003447 dimerization interface [polypeptide binding]; other site 648999003448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 648999003449 putative Zn2+ binding site [ion binding]; other site 648999003450 putative DNA binding site [nucleotide binding]; other site 648999003451 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 648999003452 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999003453 Peptidase M15; Region: Peptidase_M15_3; cl01194 648999003454 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 648999003455 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 648999003456 NADH(P)-binding; Region: NAD_binding_10; pfam13460 648999003457 NAD binding site [chemical binding]; other site 648999003458 substrate binding site [chemical binding]; other site 648999003459 putative active site [active] 648999003460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999003461 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999003462 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 648999003463 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 648999003464 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 648999003465 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 648999003466 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 648999003467 Beta protein; Region: Beta_protein; pfam14350 648999003468 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 648999003469 threonine synthase; Validated; Region: PRK08197 648999003470 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 648999003471 homodimer interface [polypeptide binding]; other site 648999003472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999003473 catalytic residue [active] 648999003474 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 648999003475 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 648999003476 active site 648999003477 DNA binding site [nucleotide binding] 648999003478 Phage-related protein [Function unknown]; Region: COG5412 648999003479 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999003480 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 648999003481 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 648999003482 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 648999003483 catalytic residues [active] 648999003484 catalytic nucleophile [active] 648999003485 Recombinase; Region: Recombinase; pfam07508 648999003486 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 648999003487 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999003488 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999003489 active site 648999003490 catalytic tetrad [active] 648999003491 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 648999003492 Cellulose binding domain; Region: CBM_2; pfam00553 648999003493 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999003494 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 648999003495 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 648999003496 D-pathway; other site 648999003497 Putative ubiquinol binding site [chemical binding]; other site 648999003498 Low-spin heme (heme b) binding site [chemical binding]; other site 648999003499 Putative water exit pathway; other site 648999003500 Binuclear center (heme o3/CuB) [ion binding]; other site 648999003501 K-pathway; other site 648999003502 Putative proton exit pathway; other site 648999003503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999003504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999003505 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 648999003506 Isochorismatase family; Region: Isochorismatase; pfam00857 648999003507 catalytic triad [active] 648999003508 conserved cis-peptide bond; other site 648999003509 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 648999003510 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 648999003511 active site 648999003512 AAA ATPase domain; Region: AAA_16; pfam13191 648999003513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999003514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999003515 DNA binding residues [nucleotide binding] 648999003516 dimerization interface [polypeptide binding]; other site 648999003517 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 648999003518 G3 box; other site 648999003519 Switch II region; other site 648999003520 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 648999003521 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 648999003522 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 648999003523 MPN+ (JAMM) motif; other site 648999003524 Zinc-binding site [ion binding]; other site 648999003525 Ubiquitin-like proteins; Region: UBQ; cl00155 648999003526 charged pocket; other site 648999003527 hydrophobic patch; other site 648999003528 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 648999003529 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 648999003530 dimer interface [polypeptide binding]; other site 648999003531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999003532 catalytic residue [active] 648999003533 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 648999003534 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999003535 ribonuclease PH; Reviewed; Region: rph; PRK00173 648999003536 Ribonuclease PH; Region: RNase_PH_bact; cd11362 648999003537 hexamer interface [polypeptide binding]; other site 648999003538 active site 648999003539 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 648999003540 active site 648999003541 dimerization interface [polypeptide binding]; other site 648999003542 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 648999003543 active sites [active] 648999003544 tetramer interface [polypeptide binding]; other site 648999003545 imidazolonepropionase; Provisional; Region: PRK14085 648999003546 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 648999003547 active site 648999003548 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 648999003549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999003550 active site 648999003551 allantoate amidohydrolase; Reviewed; Region: PRK09290 648999003552 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 648999003553 active site 648999003554 metal binding site [ion binding]; metal-binding site 648999003555 dimer interface [polypeptide binding]; other site 648999003556 urocanate hydratase; Provisional; Region: PRK05414 648999003557 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 648999003558 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 648999003559 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 648999003560 putative active site [active] 648999003561 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999003562 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 648999003563 Probable Catalytic site; other site 648999003564 metal-binding site 648999003565 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 648999003566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999003567 active site 648999003568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999003569 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999003570 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999003571 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 648999003572 Probable Catalytic site; other site 648999003573 metal-binding site 648999003574 Chain length determinant protein; Region: Wzz; pfam02706 648999003575 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 648999003576 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 648999003577 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 648999003578 substrate binding site; other site 648999003579 tetramer interface; other site 648999003580 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 648999003581 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 648999003582 NAD binding site [chemical binding]; other site 648999003583 substrate binding site [chemical binding]; other site 648999003584 homodimer interface [polypeptide binding]; other site 648999003585 active site 648999003586 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 648999003587 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 648999003588 NADP binding site [chemical binding]; other site 648999003589 active site 648999003590 putative substrate binding site [chemical binding]; other site 648999003591 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 648999003592 Bacterial sugar transferase; Region: Bac_transf; pfam02397 648999003593 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 648999003594 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 648999003595 Pollen allergen; Region: Pollen_allerg_1; cl08320 648999003596 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999003597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999003598 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999003599 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999003600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999003601 Coenzyme A binding pocket [chemical binding]; other site 648999003602 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 648999003603 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 648999003604 catalytic triad [active] 648999003605 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 648999003606 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 648999003607 PDGLE domain; Region: PDGLE; pfam13190 648999003608 Cobalt transport protein; Region: CbiQ; cl00463 648999003609 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999003610 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 648999003611 Walker A/P-loop; other site 648999003612 ATP binding site [chemical binding]; other site 648999003613 Q-loop/lid; other site 648999003614 ABC transporter signature motif; other site 648999003615 Walker B; other site 648999003616 D-loop; other site 648999003617 H-loop/switch region; other site 648999003618 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999003619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999003620 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999003621 Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917 648999003622 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 648999003623 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 648999003624 catalytic residues [active] 648999003625 Methylamine utilisation protein MauE; Region: MauE; pfam07291 648999003626 RNA polymerase sigma factor; Provisional; Region: PRK12535 648999003627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999003628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999003629 DNA binding residues [nucleotide binding] 648999003630 CopC domain; Region: CopC; pfam04234 648999003631 Copper resistance protein D; Region: CopD; cl00563 648999003632 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 648999003633 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 648999003634 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 648999003635 catalytic site [active] 648999003636 putative active site [active] 648999003637 putative substrate binding site [chemical binding]; other site 648999003638 dimer interface [polypeptide binding]; other site 648999003639 Bacterial Ig-like domain; Region: Big_5; pfam13205 648999003640 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 648999003641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 648999003642 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 648999003643 Bacterial Ig-like domain; Region: Big_5; pfam13205 648999003644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 648999003645 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 648999003646 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 648999003647 hypothetical protein; Provisional; Region: PRK06762 648999003648 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 648999003649 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999003650 DNA binding residues [nucleotide binding] 648999003651 drug binding residues [chemical binding]; other site 648999003652 dimer interface [polypeptide binding]; other site 648999003653 Family description; Region: VCBS; pfam13517 648999003654 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 648999003655 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 648999003656 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 648999003657 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 648999003658 RHS Repeat; Region: RHS_repeat; pfam05593 648999003659 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 648999003660 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 648999003661 protein-splicing catalytic site; other site 648999003662 thioester formation/cholesterol transfer; other site 648999003663 Pretoxin HINT domain; Region: PT-HINT; pfam07591 648999003664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999003665 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999003666 von Willebrand factor type D domain; Region: VWD; cl02516 648999003667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999003668 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 648999003669 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 648999003670 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 648999003671 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 648999003672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999003673 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 648999003674 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 648999003675 Clp protease ATP binding subunit; Region: clpC; CHL00095 648999003676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999003677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999003678 Protein of unknown function, DUF393; Region: DUF393; pfam04134 648999003679 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 648999003680 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 648999003681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999003682 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 648999003683 non-specific DNA interactions [nucleotide binding]; other site 648999003684 DNA binding site [nucleotide binding] 648999003685 sequence specific DNA binding site [nucleotide binding]; other site 648999003686 putative cAMP binding site [chemical binding]; other site 648999003687 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999003688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999003689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003691 Walker A/P-loop; other site 648999003692 ATP binding site [chemical binding]; other site 648999003693 Q-loop/lid; other site 648999003694 ABC transporter signature motif; other site 648999003695 Walker B; other site 648999003696 D-loop; other site 648999003697 H-loop/switch region; other site 648999003698 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999003699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999003700 Walker A/P-loop; other site 648999003701 ATP binding site [chemical binding]; other site 648999003702 ABC transporter signature motif; other site 648999003703 Walker B; other site 648999003704 D-loop; other site 648999003705 H-loop/switch region; other site 648999003706 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 648999003707 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 648999003708 substrate binding site [chemical binding]; other site 648999003709 dimer interface [polypeptide binding]; other site 648999003710 ATP binding site [chemical binding]; other site 648999003711 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999003712 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999003713 enoyl-CoA hydratase; Provisional; Region: PRK05862 648999003714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999003715 substrate binding site [chemical binding]; other site 648999003716 oxyanion hole (OAH) forming residues; other site 648999003717 trimer interface [polypeptide binding]; other site 648999003718 hypothetical protein; Provisional; Region: PRK05858 648999003719 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 648999003720 PYR/PP interface [polypeptide binding]; other site 648999003721 dimer interface [polypeptide binding]; other site 648999003722 TPP binding site [chemical binding]; other site 648999003723 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 648999003724 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 648999003725 TPP-binding site; other site 648999003726 dimer interface [polypeptide binding]; other site 648999003727 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 648999003728 Domain of unknown function (DUF202); Region: DUF202; cl09954 648999003729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 648999003730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999003731 Coenzyme A binding pocket [chemical binding]; other site 648999003732 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 648999003733 Ligand binding site [chemical binding]; other site 648999003734 Electron transfer flavoprotein domain; Region: ETF; pfam01012 648999003735 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 648999003736 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 648999003737 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 648999003738 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999003739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999003740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999003741 DNA binding residues [nucleotide binding] 648999003742 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 648999003743 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 648999003744 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 648999003745 active site 648999003746 putative catalytic site [active] 648999003747 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 648999003748 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 648999003749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999003750 catalytic residue [active] 648999003751 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 648999003752 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 648999003753 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 648999003754 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999003755 active site 648999003756 metal binding site [ion binding]; metal-binding site 648999003757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999003758 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 648999003759 PemK-like protein; Region: PemK; pfam02452 648999003760 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 648999003761 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 648999003762 nucleotide binding pocket [chemical binding]; other site 648999003763 K-X-D-G motif; other site 648999003764 catalytic site [active] 648999003765 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 648999003766 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 648999003767 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 648999003768 Dimer interface [polypeptide binding]; other site 648999003769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999003770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999003771 metal binding site [ion binding]; metal-binding site 648999003772 active site 648999003773 I-site; other site 648999003774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999003775 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 648999003776 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 648999003777 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 648999003778 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 648999003779 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 648999003780 GatB domain; Region: GatB_Yqey; smart00845 648999003781 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 648999003782 TPP-binding site [chemical binding]; other site 648999003783 PYR/PP interface [polypeptide binding]; other site 648999003784 dimer interface [polypeptide binding]; other site 648999003785 TPP binding site [chemical binding]; other site 648999003786 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 648999003787 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999003788 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999003789 active site 648999003790 metal binding site [ion binding]; metal-binding site 648999003791 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 648999003792 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 648999003793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999003794 GAF domain; Region: GAF; pfam01590 648999003795 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 648999003796 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999003797 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999003798 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 648999003799 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 648999003800 putative ligand binding site [chemical binding]; other site 648999003801 putative NAD binding site [chemical binding]; other site 648999003802 catalytic site [active] 648999003803 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 648999003804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999003805 I-site; other site 648999003806 active site 648999003807 metal binding site [ion binding]; metal-binding site 648999003808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999003809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999003810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999003811 DNA binding site [nucleotide binding] 648999003812 domain linker motif; other site 648999003813 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999003814 ligand binding site [chemical binding]; other site 648999003815 dimerization interface [polypeptide binding]; other site 648999003816 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 648999003817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999003818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999003819 dimer interface [polypeptide binding]; other site 648999003820 conserved gate region; other site 648999003821 putative PBP binding loops; other site 648999003822 ABC-ATPase subunit interface; other site 648999003823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999003825 dimer interface [polypeptide binding]; other site 648999003826 conserved gate region; other site 648999003827 putative PBP binding loops; other site 648999003828 ABC-ATPase subunit interface; other site 648999003829 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 648999003830 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 648999003831 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 648999003832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999003833 dimerization interface [polypeptide binding]; other site 648999003834 putative DNA binding site [nucleotide binding]; other site 648999003835 putative Zn2+ binding site [ion binding]; other site 648999003836 Sulfate transporter family; Region: Sulfate_transp; pfam00916 648999003837 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 648999003838 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 648999003839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999003840 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999003841 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 648999003842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999003843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999003844 metal binding site [ion binding]; metal-binding site 648999003845 active site 648999003846 I-site; other site 648999003847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999003848 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 648999003849 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 648999003850 PYR/PP interface [polypeptide binding]; other site 648999003851 dimer interface [polypeptide binding]; other site 648999003852 TPP binding site [chemical binding]; other site 648999003853 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 648999003854 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 648999003855 TPP-binding site [chemical binding]; other site 648999003856 dimer interface [polypeptide binding]; other site 648999003857 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 648999003858 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 648999003859 putative valine binding site [chemical binding]; other site 648999003860 dimer interface [polypeptide binding]; other site 648999003861 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 648999003862 ketol-acid reductoisomerase; Provisional; Region: PRK05479 648999003863 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 648999003864 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 648999003865 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 648999003866 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 648999003867 ligand binding site [chemical binding]; other site 648999003868 NAD binding site [chemical binding]; other site 648999003869 dimerization interface [polypeptide binding]; other site 648999003870 catalytic site [active] 648999003871 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 648999003872 putative L-serine binding site [chemical binding]; other site 648999003873 ApbE family; Region: ApbE; pfam02424 648999003874 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 648999003875 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 648999003876 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 648999003877 homodimer interface [polypeptide binding]; other site 648999003878 substrate-cofactor binding pocket; other site 648999003879 catalytic residue [active] 648999003880 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 648999003881 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 648999003882 active site 648999003883 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 648999003884 Uncharacterized conserved protein [Function unknown]; Region: COG2128 648999003885 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 648999003886 peroxiredoxin; Region: AhpC; TIGR03137 648999003887 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 648999003888 dimer interface [polypeptide binding]; other site 648999003889 decamer (pentamer of dimers) interface [polypeptide binding]; other site 648999003890 catalytic triad [active] 648999003891 peroxidatic and resolving cysteines [active] 648999003892 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 648999003893 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 648999003894 active site 648999003895 catalytic residues [active] 648999003896 metal binding site [ion binding]; metal-binding site 648999003897 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 648999003898 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999003899 putative catalytic site [active] 648999003900 putative phosphate binding site [ion binding]; other site 648999003901 putative metal binding site [ion binding]; other site 648999003902 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999003903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999003904 Walker A motif; other site 648999003905 ATP binding site [chemical binding]; other site 648999003906 Walker B motif; other site 648999003907 arginine finger; other site 648999003908 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999003909 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 648999003910 metal ion-dependent adhesion site (MIDAS); other site 648999003911 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 648999003912 hypothetical protein; Provisional; Region: PRK09256 648999003913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999003914 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999003915 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 648999003916 active site 648999003917 catalytic triad [active] 648999003918 oxyanion hole [active] 648999003919 Cellulose binding domain; Region: CBM_2; pfam00553 648999003920 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 648999003921 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 648999003922 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 648999003923 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 648999003924 Transcriptional regulator [Transcription]; Region: IclR; COG1414 648999003925 Bacterial transcriptional regulator; Region: IclR; pfam01614 648999003926 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 648999003927 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 648999003928 substrate binding site [chemical binding]; other site 648999003929 ligand binding site [chemical binding]; other site 648999003930 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 648999003931 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 648999003932 substrate binding site [chemical binding]; other site 648999003933 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 648999003934 IHF dimer interface [polypeptide binding]; other site 648999003935 IHF - DNA interface [nucleotide binding]; other site 648999003936 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999003937 putative catalytic site [active] 648999003938 putative metal binding site [ion binding]; other site 648999003939 putative phosphate binding site [ion binding]; other site 648999003940 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 648999003941 active site 648999003942 Ap6A binding site [chemical binding]; other site 648999003943 nudix motif; other site 648999003944 metal binding site [ion binding]; metal-binding site 648999003945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999003946 catalytic core [active] 648999003947 polyphosphate kinase; Provisional; Region: PRK05443 648999003948 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 648999003949 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 648999003950 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 648999003951 putative domain interface [polypeptide binding]; other site 648999003952 putative active site [active] 648999003953 catalytic site [active] 648999003954 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 648999003955 putative domain interface [polypeptide binding]; other site 648999003956 putative active site [active] 648999003957 catalytic site [active] 648999003958 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999003959 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999003960 putative acyl-acceptor binding pocket; other site 648999003961 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 648999003962 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 648999003963 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 648999003964 cystathionine gamma-lyase; Validated; Region: PRK07582 648999003965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999003966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999003967 catalytic residue [active] 648999003968 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 648999003969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999003970 S-adenosylmethionine binding site [chemical binding]; other site 648999003971 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999003972 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999003973 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999003974 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999003975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999003976 non-specific DNA binding site [nucleotide binding]; other site 648999003977 salt bridge; other site 648999003978 sequence-specific DNA binding site [nucleotide binding]; other site 648999003979 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 648999003980 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 648999003981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999003982 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 648999003983 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 648999003984 AsnC family; Region: AsnC_trans_reg; pfam01037 648999003985 thiamine monophosphate kinase; Provisional; Region: PRK05731 648999003986 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 648999003987 ATP binding site [chemical binding]; other site 648999003988 dimerization interface [polypeptide binding]; other site 648999003989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999003990 Coenzyme A binding pocket [chemical binding]; other site 648999003991 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 648999003992 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 648999003993 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 648999003994 DAK2 domain; Region: Dak2; cl03685 648999003995 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 648999003996 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 648999003997 generic binding surface II; other site 648999003998 ssDNA binding site; other site 648999003999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999004000 ATP binding site [chemical binding]; other site 648999004001 putative Mg++ binding site [ion binding]; other site 648999004002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999004003 nucleotide binding region [chemical binding]; other site 648999004004 ATP-binding site [chemical binding]; other site 648999004005 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999004006 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999004007 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 648999004008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999004009 S-adenosylmethionine binding site [chemical binding]; other site 648999004010 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 648999004011 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 648999004012 active site 648999004013 (T/H)XGH motif; other site 648999004014 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 648999004015 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 648999004016 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 648999004017 ribonuclease III; Reviewed; Region: rnc; PRK00102 648999004018 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 648999004019 dimerization interface [polypeptide binding]; other site 648999004020 active site 648999004021 metal binding site [ion binding]; metal-binding site 648999004022 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 648999004023 dsRNA binding site [nucleotide binding]; other site 648999004024 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 648999004025 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 648999004026 DNA binding site [nucleotide binding] 648999004027 catalytic residue [active] 648999004028 H2TH interface [polypeptide binding]; other site 648999004029 putative catalytic residues [active] 648999004030 turnover-facilitating residue; other site 648999004031 intercalation triad [nucleotide binding]; other site 648999004032 8OG recognition residue [nucleotide binding]; other site 648999004033 putative reading head residues; other site 648999004034 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 648999004035 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 648999004036 MMPL family; Region: MMPL; pfam03176 648999004037 MMPL family; Region: MMPL; pfam03176 648999004038 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 648999004039 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 648999004040 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 648999004041 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 648999004042 AAA domain; Region: AAA_23; pfam13476 648999004043 Walker A/P-loop; other site 648999004044 ATP binding site [chemical binding]; other site 648999004045 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 648999004046 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 648999004047 ABC transporter signature motif; other site 648999004048 Walker B; other site 648999004049 D-loop; other site 648999004050 H-loop/switch region; other site 648999004051 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 648999004052 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 648999004053 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 648999004054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999004055 putative DNA binding site [nucleotide binding]; other site 648999004056 putative Zn2+ binding site [ion binding]; other site 648999004057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999004058 Ligand Binding Site [chemical binding]; other site 648999004059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999004060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999004061 putative substrate translocation pore; other site 648999004062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999004063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999004064 MarR family; Region: MarR_2; cl17246 648999004065 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 648999004066 putative active site [active] 648999004067 putative metal binding site [ion binding]; other site 648999004068 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999004069 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 648999004070 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 648999004071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999004072 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 648999004073 Phosphotransferase enzyme family; Region: APH; pfam01636 648999004074 active site 648999004075 substrate binding site [chemical binding]; other site 648999004076 ATP binding site [chemical binding]; other site 648999004077 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 648999004078 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 648999004079 Nitrogen regulatory protein P-II; Region: P-II; smart00938 648999004080 PII uridylyl-transferase; Provisional; Region: PRK03381 648999004081 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 648999004082 metal binding triad; other site 648999004083 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 648999004084 Family of unknown function (DUF706); Region: DUF706; pfam05153 648999004085 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 648999004086 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 648999004087 signal recognition particle protein; Provisional; Region: PRK10867 648999004088 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 648999004089 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 648999004090 P loop; other site 648999004091 GTP binding site [chemical binding]; other site 648999004092 Signal peptide binding domain; Region: SRP_SPB; pfam02978 648999004093 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 648999004094 putative active site [active] 648999004095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999004096 active site 648999004097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999004098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999004099 prolyl-tRNA synthetase; Provisional; Region: PRK08661 648999004100 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 648999004101 dimer interface [polypeptide binding]; other site 648999004102 motif 1; other site 648999004103 active site 648999004104 motif 2; other site 648999004105 motif 3; other site 648999004106 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 648999004107 anticodon binding site; other site 648999004108 Protein of unknown function (DUF402); Region: DUF402; pfam04167 648999004109 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 648999004110 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 648999004111 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 648999004112 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 648999004113 RimM N-terminal domain; Region: RimM; pfam01782 648999004114 PRC-barrel domain; Region: PRC; pfam05239 648999004115 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 648999004116 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 648999004117 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 648999004118 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 648999004119 Catalytic site [active] 648999004120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 648999004121 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 648999004122 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 648999004123 Catalytic site [active] 648999004124 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 648999004125 nudix motif; other site 648999004126 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 648999004127 RNA/DNA hybrid binding site [nucleotide binding]; other site 648999004128 active site 648999004129 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 648999004130 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 648999004131 Moco binding site; other site 648999004132 metal coordination site [ion binding]; other site 648999004133 dimerization interface [polypeptide binding]; other site 648999004134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999004135 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999004136 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999004137 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999004138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999004139 catalytic residue [active] 648999004140 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 648999004141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999004142 active site 648999004143 DNA binding site [nucleotide binding] 648999004144 Int/Topo IB signature motif; other site 648999004145 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 648999004146 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 648999004147 catalytic residues [active] 648999004148 catalytic nucleophile [active] 648999004149 Recombinase; Region: Recombinase; pfam07508 648999004150 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 648999004151 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999004152 PCI domain; Region: PCI; cl02111 648999004153 Helix-turn-helix domain; Region: HTH_36; pfam13730 648999004154 Domain of unknown function DUF87; Region: DUF87; pfam01935 648999004155 Helix-turn-helix domain; Region: HTH_36; pfam13730 648999004156 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 648999004157 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 648999004158 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 648999004159 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 648999004160 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 648999004161 hypothetical protein; Reviewed; Region: PRK12497 648999004162 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 648999004163 rRNA interaction site [nucleotide binding]; other site 648999004164 S8 interaction site; other site 648999004165 putative laminin-1 binding site; other site 648999004166 elongation factor Ts; Provisional; Region: tsf; PRK09377 648999004167 UBA/TS-N domain; Region: UBA; pfam00627 648999004168 Elongation factor TS; Region: EF_TS; pfam00889 648999004169 Elongation factor TS; Region: EF_TS; pfam00889 648999004170 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 648999004171 putative nucleotide binding site [chemical binding]; other site 648999004172 uridine monophosphate binding site [chemical binding]; other site 648999004173 homohexameric interface [polypeptide binding]; other site 648999004174 ribosome recycling factor; Reviewed; Region: frr; PRK00083 648999004175 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 648999004176 hinge region; other site 648999004177 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 648999004178 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 648999004179 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 648999004180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999004181 FeS/SAM binding site; other site 648999004182 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999004183 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999004184 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999004185 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 648999004186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 648999004187 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 648999004188 iron-sulfur cluster [ion binding]; other site 648999004189 [2Fe-2S] cluster binding site [ion binding]; other site 648999004190 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 648999004191 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 648999004192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999004193 hypothetical protein; Provisional; Region: PRK06771 648999004194 hypothetical protein; Provisional; Region: PRK06771 648999004195 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 648999004196 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 648999004197 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 648999004198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999004199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004200 Coenzyme A binding pocket [chemical binding]; other site 648999004201 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 648999004202 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 648999004203 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 648999004204 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 648999004205 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 648999004206 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 648999004207 active site 648999004208 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 648999004209 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 648999004210 putative substrate binding region [chemical binding]; other site 648999004211 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 648999004212 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 648999004213 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 648999004214 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999004215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999004216 dimerization interface [polypeptide binding]; other site 648999004217 putative DNA binding site [nucleotide binding]; other site 648999004218 putative Zn2+ binding site [ion binding]; other site 648999004219 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999004220 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999004221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999004222 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 648999004223 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999004224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004225 Walker A/P-loop; other site 648999004226 ATP binding site [chemical binding]; other site 648999004227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004228 ABC transporter signature motif; other site 648999004229 Walker B; other site 648999004230 D-loop; other site 648999004231 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 648999004232 Predicted membrane protein [Function unknown]; Region: COG1511 648999004233 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 648999004234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999004235 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 648999004236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999004237 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999004238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004239 Walker A/P-loop; other site 648999004240 ATP binding site [chemical binding]; other site 648999004241 Q-loop/lid; other site 648999004242 ABC transporter signature motif; other site 648999004243 Walker B; other site 648999004244 D-loop; other site 648999004245 H-loop/switch region; other site 648999004246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999004247 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999004248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004249 Walker A/P-loop; other site 648999004250 ATP binding site [chemical binding]; other site 648999004251 Q-loop/lid; other site 648999004252 ABC transporter signature motif; other site 648999004253 Walker B; other site 648999004254 D-loop; other site 648999004255 H-loop/switch region; other site 648999004256 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 648999004257 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 648999004258 active site 648999004259 FMN binding site [chemical binding]; other site 648999004260 substrate binding site [chemical binding]; other site 648999004261 homotetramer interface [polypeptide binding]; other site 648999004262 catalytic residue [active] 648999004263 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 648999004264 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 648999004265 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 648999004266 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999004267 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 648999004268 putative dimer interface [polypeptide binding]; other site 648999004269 N-terminal domain interface [polypeptide binding]; other site 648999004270 putative substrate binding pocket (H-site) [chemical binding]; other site 648999004271 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 648999004272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999004273 dimer interface [polypeptide binding]; other site 648999004274 active site 648999004275 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999004276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999004277 S-adenosylmethionine binding site [chemical binding]; other site 648999004278 PAS domain S-box; Region: sensory_box; TIGR00229 648999004279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 648999004280 putative active site [active] 648999004281 heme pocket [chemical binding]; other site 648999004282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999004283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999004284 metal binding site [ion binding]; metal-binding site 648999004285 active site 648999004286 I-site; other site 648999004287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999004288 Protein of unknown function (DUF456); Region: DUF456; pfam04306 648999004289 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 648999004290 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999004291 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 648999004292 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999004293 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999004294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999004295 non-specific DNA binding site [nucleotide binding]; other site 648999004296 salt bridge; other site 648999004297 sequence-specific DNA binding site [nucleotide binding]; other site 648999004298 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 648999004299 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 648999004300 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 648999004301 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 648999004302 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999004303 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 648999004304 NAD(P) binding site [chemical binding]; other site 648999004305 catalytic residues [active] 648999004306 short chain dehydrogenase; Provisional; Region: PRK06057 648999004307 classical (c) SDRs; Region: SDR_c; cd05233 648999004308 NAD(P) binding site [chemical binding]; other site 648999004309 active site 648999004310 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 648999004311 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 648999004312 catalytic triad [active] 648999004313 GAF domain; Region: GAF_3; pfam13492 648999004314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999004315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999004316 dimer interface [polypeptide binding]; other site 648999004317 phosphorylation site [posttranslational modification] 648999004318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999004319 ATP binding site [chemical binding]; other site 648999004320 Mg2+ binding site [ion binding]; other site 648999004321 G-X-G motif; other site 648999004322 Response regulator receiver domain; Region: Response_reg; pfam00072 648999004323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999004324 active site 648999004325 phosphorylation site [posttranslational modification] 648999004326 intermolecular recognition site; other site 648999004327 dimerization interface [polypeptide binding]; other site 648999004328 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 648999004329 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999004330 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999004331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 648999004332 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999004333 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999004334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999004335 anti sigma factor interaction site; other site 648999004336 regulatory phosphorylation site [posttranslational modification]; other site 648999004337 methionine aminopeptidase; Provisional; Region: PRK12318 648999004338 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 648999004339 active site 648999004340 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 648999004341 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 648999004342 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999004343 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999004344 Walker A/P-loop; other site 648999004345 ATP binding site [chemical binding]; other site 648999004346 Q-loop/lid; other site 648999004347 ABC transporter signature motif; other site 648999004348 Walker B; other site 648999004349 D-loop; other site 648999004350 H-loop/switch region; other site 648999004351 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999004352 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999004353 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 648999004354 dinuclear metal binding motif [ion binding]; other site 648999004355 ribosome maturation protein RimP; Reviewed; Region: PRK00092 648999004356 hypothetical protein; Provisional; Region: PRK14641 648999004357 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 648999004358 putative oligomer interface [polypeptide binding]; other site 648999004359 putative RNA binding site [nucleotide binding]; other site 648999004360 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 648999004361 NusA N-terminal domain; Region: NusA_N; pfam08529 648999004362 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 648999004363 RNA binding site [nucleotide binding]; other site 648999004364 homodimer interface [polypeptide binding]; other site 648999004365 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 648999004366 G-X-X-G motif; other site 648999004367 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 648999004368 G-X-X-G motif; other site 648999004369 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 648999004370 putative RNA binding cleft [nucleotide binding]; other site 648999004371 translation initiation factor IF-2; Region: IF-2; TIGR00487 648999004372 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 648999004373 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 648999004374 G1 box; other site 648999004375 putative GEF interaction site [polypeptide binding]; other site 648999004376 GTP/Mg2+ binding site [chemical binding]; other site 648999004377 Switch I region; other site 648999004378 G2 box; other site 648999004379 G3 box; other site 648999004380 Switch II region; other site 648999004381 G4 box; other site 648999004382 G5 box; other site 648999004383 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 648999004384 Translation-initiation factor 2; Region: IF-2; pfam11987 648999004385 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 648999004386 Methyltransferase domain; Region: Methyltransf_26; pfam13659 648999004387 Protein of unknown function (DUF503); Region: DUF503; pfam04456 648999004388 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 648999004389 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 648999004390 DHH family; Region: DHH; pfam01368 648999004391 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 648999004392 putative efflux protein, MATE family; Region: matE; TIGR00797 648999004393 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 648999004394 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 648999004395 RNA binding site [nucleotide binding]; other site 648999004396 active site 648999004397 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 648999004398 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 648999004399 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 648999004400 active site 648999004401 Riboflavin kinase; Region: Flavokinase; smart00904 648999004402 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 648999004403 16S/18S rRNA binding site [nucleotide binding]; other site 648999004404 S13e-L30e interaction site [polypeptide binding]; other site 648999004405 25S rRNA binding site [nucleotide binding]; other site 648999004406 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 648999004407 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 648999004408 RNase E interface [polypeptide binding]; other site 648999004409 trimer interface [polypeptide binding]; other site 648999004410 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 648999004411 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 648999004412 RNase E interface [polypeptide binding]; other site 648999004413 trimer interface [polypeptide binding]; other site 648999004414 active site 648999004415 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 648999004416 putative nucleic acid binding region [nucleotide binding]; other site 648999004417 G-X-X-G motif; other site 648999004418 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 648999004419 RNA binding site [nucleotide binding]; other site 648999004420 domain interface; other site 648999004421 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 648999004422 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 648999004423 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 648999004424 dihydrodipicolinate reductase; Provisional; Region: PRK00048 648999004425 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 648999004426 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 648999004427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999004428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004429 Coenzyme A binding pocket [chemical binding]; other site 648999004430 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 648999004431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 648999004432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004433 Coenzyme A binding pocket [chemical binding]; other site 648999004434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 648999004435 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 648999004436 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 648999004437 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 648999004438 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 648999004439 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 648999004440 dimer interface [polypeptide binding]; other site 648999004441 active site 648999004442 catalytic residue [active] 648999004443 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 648999004444 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999004445 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 648999004446 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 648999004447 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 648999004448 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 648999004449 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 648999004450 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 648999004451 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999004452 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 648999004453 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 648999004454 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 648999004455 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 648999004456 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 648999004457 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 648999004458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999004459 FeS/SAM binding site; other site 648999004460 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 648999004461 Competence-damaged protein; Region: CinA; pfam02464 648999004462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999004463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999004464 non-specific DNA binding site [nucleotide binding]; other site 648999004465 salt bridge; other site 648999004466 sequence-specific DNA binding site [nucleotide binding]; other site 648999004467 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 648999004468 Fibronectin type III domain; Region: fn3; pfam00041 648999004469 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999004470 Interdomain contacts; other site 648999004471 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 648999004472 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 648999004473 putative DNA binding site [nucleotide binding]; other site 648999004474 catalytic residue [active] 648999004475 putative H2TH interface [polypeptide binding]; other site 648999004476 putative catalytic residues [active] 648999004477 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 648999004478 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 648999004479 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 648999004480 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 648999004481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999004482 ATP binding site [chemical binding]; other site 648999004483 putative Mg++ binding site [ion binding]; other site 648999004484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999004485 nucleotide binding region [chemical binding]; other site 648999004486 ATP-binding site [chemical binding]; other site 648999004487 DEAD/H associated; Region: DEAD_assoc; pfam08494 648999004488 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 648999004489 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999004490 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 648999004491 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 648999004492 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 648999004493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999004494 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 648999004495 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 648999004496 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 648999004497 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999004498 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999004499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999004500 Transporter associated domain; Region: CorC_HlyC; pfam03471 648999004501 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999004502 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999004503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999004504 SpoOM protein; Region: Spo0M; pfam07070 648999004505 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 648999004506 leucine export protein LeuE; Provisional; Region: PRK10958 648999004507 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 648999004508 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999004509 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999004510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999004511 DNA-binding site [nucleotide binding]; DNA binding site 648999004512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999004513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999004514 catalytic residue [active] 648999004515 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 648999004516 Fe-S cluster binding site [ion binding]; other site 648999004517 active site 648999004518 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999004519 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 648999004520 aromatic arch; other site 648999004521 DCoH dimer interaction site [polypeptide binding]; other site 648999004522 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 648999004523 DCoH tetramer interaction site [polypeptide binding]; other site 648999004524 substrate binding site [chemical binding]; other site 648999004525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999004526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999004527 active site 648999004528 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 648999004529 recombinase A; Provisional; Region: recA; PRK09354 648999004530 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 648999004531 hexamer interface [polypeptide binding]; other site 648999004532 Walker A motif; other site 648999004533 ATP binding site [chemical binding]; other site 648999004534 Walker B motif; other site 648999004535 recombination regulator RecX; Reviewed; Region: recX; PRK00117 648999004536 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 648999004537 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 648999004538 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 648999004539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999004540 Zn2+ binding site [ion binding]; other site 648999004541 Mg2+ binding site [ion binding]; other site 648999004542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999004543 dimer interface [polypeptide binding]; other site 648999004544 conserved gate region; other site 648999004545 putative PBP binding loops; other site 648999004546 ABC-ATPase subunit interface; other site 648999004547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999004548 dimer interface [polypeptide binding]; other site 648999004549 conserved gate region; other site 648999004550 putative PBP binding loops; other site 648999004551 ABC-ATPase subunit interface; other site 648999004552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999004553 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 648999004554 substrate binding pocket [chemical binding]; other site 648999004555 membrane-bound complex binding site; other site 648999004556 hinge residues; other site 648999004557 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 648999004558 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 648999004559 Walker A/P-loop; other site 648999004560 ATP binding site [chemical binding]; other site 648999004561 Q-loop/lid; other site 648999004562 ABC transporter signature motif; other site 648999004563 Walker B; other site 648999004564 D-loop; other site 648999004565 H-loop/switch region; other site 648999004566 selenophosphate synthetase; Provisional; Region: PRK00943 648999004567 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 648999004568 dimerization interface [polypeptide binding]; other site 648999004569 putative ATP binding site [chemical binding]; other site 648999004570 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 648999004571 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 648999004572 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 648999004573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999004574 FeS/SAM binding site; other site 648999004575 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 648999004576 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 648999004577 CBD_II domain; Region: CBD_II; smart00637 648999004578 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 648999004579 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 648999004580 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 648999004581 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 648999004582 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 648999004583 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 648999004584 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 648999004585 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 648999004586 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 648999004587 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 648999004588 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 648999004589 Malic enzyme, N-terminal domain; Region: malic; pfam00390 648999004590 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 648999004591 NAD(P) binding pocket [chemical binding]; other site 648999004592 GTPases [General function prediction only]; Region: HflX; COG2262 648999004593 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 648999004594 HflX GTPase family; Region: HflX; cd01878 648999004595 G1 box; other site 648999004596 GTP/Mg2+ binding site [chemical binding]; other site 648999004597 Switch I region; other site 648999004598 G2 box; other site 648999004599 G3 box; other site 648999004600 Switch II region; other site 648999004601 G4 box; other site 648999004602 G5 box; other site 648999004603 LexA repressor; Validated; Region: PRK00215 648999004604 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 648999004605 putative switch regulator; other site 648999004606 non-specific DNA interactions [nucleotide binding]; other site 648999004607 DNA binding site [nucleotide binding] 648999004608 sequence specific DNA binding site [nucleotide binding]; other site 648999004609 putative cAMP binding site [chemical binding]; other site 648999004610 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 648999004611 Catalytic site [active] 648999004612 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 648999004613 ATP cone domain; Region: ATP-cone; pfam03477 648999004614 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 648999004615 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 648999004616 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 648999004617 active site 648999004618 dimer interface [polypeptide binding]; other site 648999004619 effector binding site; other site 648999004620 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 648999004621 TSCPD domain; Region: TSCPD; pfam12637 648999004622 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999004623 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 648999004624 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999004625 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 648999004626 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 648999004627 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 648999004628 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 648999004629 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 648999004630 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 648999004631 active site residue [active] 648999004632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 648999004633 active site residue [active] 648999004634 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 648999004635 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 648999004636 active site 648999004637 Zn binding site [ion binding]; other site 648999004638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999004639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004640 Coenzyme A binding pocket [chemical binding]; other site 648999004641 CoA binding domain; Region: CoA_binding_2; pfam13380 648999004642 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 648999004643 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 648999004644 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 648999004645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999004646 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 648999004647 putative hydrophobic ligand binding site [chemical binding]; other site 648999004648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999004649 dimerization interface [polypeptide binding]; other site 648999004650 putative DNA binding site [nucleotide binding]; other site 648999004651 putative Zn2+ binding site [ion binding]; other site 648999004652 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 648999004653 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 648999004654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999004655 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999004656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999004657 DNA binding residues [nucleotide binding] 648999004658 SpoOM protein; Region: Spo0M; pfam07070 648999004659 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 648999004660 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 648999004661 putative active site [active] 648999004662 dimerization interface [polypeptide binding]; other site 648999004663 putative tRNAtyr binding site [nucleotide binding]; other site 648999004664 putative methyltransferase; Provisional; Region: PRK14967 648999004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999004666 S-adenosylmethionine binding site [chemical binding]; other site 648999004667 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 648999004668 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 648999004669 calcium binding site 2 [ion binding]; other site 648999004670 active site 648999004671 catalytic triad [active] 648999004672 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 648999004673 calcium binding site 1 [ion binding]; other site 648999004674 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 648999004675 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999004676 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 648999004677 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 648999004678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 648999004679 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999004680 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 648999004681 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 648999004682 Predicted membrane protein [Function unknown]; Region: COG2860 648999004683 UPF0126 domain; Region: UPF0126; pfam03458 648999004684 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 648999004685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999004686 ATP binding site [chemical binding]; other site 648999004687 putative Mg++ binding site [ion binding]; other site 648999004688 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 648999004689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 648999004690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999004691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999004692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999004693 DNA binding residues [nucleotide binding] 648999004694 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999004695 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 648999004696 active site 648999004697 dimerization interface [polypeptide binding]; other site 648999004698 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 648999004699 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 648999004700 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 648999004701 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 648999004702 trimer interface [polypeptide binding]; other site 648999004703 active site 648999004704 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 648999004705 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 648999004706 ssDNA binding site; other site 648999004707 generic binding surface II; other site 648999004708 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 648999004709 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 648999004710 TrkA-N domain; Region: TrkA_N; pfam02254 648999004711 TrkA-C domain; Region: TrkA_C; pfam02080 648999004712 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 648999004713 TrkA-N domain; Region: TrkA_N; pfam02254 648999004714 TrkA-C domain; Region: TrkA_C; pfam02080 648999004715 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 648999004716 K+ potassium transporter; Region: K_trans; cl15781 648999004717 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 648999004718 TRAM domain; Region: TRAM; pfam01938 648999004719 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 648999004720 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 648999004721 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 648999004722 TPP-binding site; other site 648999004723 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 648999004724 PYR/PP interface [polypeptide binding]; other site 648999004725 dimer interface [polypeptide binding]; other site 648999004726 TPP binding site [chemical binding]; other site 648999004727 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999004728 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 648999004729 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999004730 Trp docking motif [polypeptide binding]; other site 648999004731 active site 648999004732 PQQ-like domain; Region: PQQ_2; pfam13360 648999004733 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999004734 PQQ-like domain; Region: PQQ_2; pfam13360 648999004735 Trp docking motif [polypeptide binding]; other site 648999004736 active site 648999004737 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 648999004738 putative active site [active] 648999004739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999004740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999004741 active site 648999004742 phosphorylation site [posttranslational modification] 648999004743 intermolecular recognition site; other site 648999004744 dimerization interface [polypeptide binding]; other site 648999004745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999004746 DNA binding site [nucleotide binding] 648999004747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999004748 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 648999004749 dimerization interface [polypeptide binding]; other site 648999004750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999004751 dimer interface [polypeptide binding]; other site 648999004752 phosphorylation site [posttranslational modification] 648999004753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999004754 ATP binding site [chemical binding]; other site 648999004755 Mg2+ binding site [ion binding]; other site 648999004756 G-X-G motif; other site 648999004757 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 648999004758 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 648999004759 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999004760 substrate binding site [chemical binding]; other site 648999004761 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 648999004762 oxyanion hole (OAH) forming residues; other site 648999004763 trimer interface [polypeptide binding]; other site 648999004764 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999004765 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999004766 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999004767 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 648999004768 dimer interface [polypeptide binding]; other site 648999004769 active site 648999004770 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 648999004771 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 648999004772 catalytic site [active] 648999004773 putative active site [active] 648999004774 putative substrate binding site [chemical binding]; other site 648999004775 Helicase and RNase D C-terminal; Region: HRDC; smart00341 648999004776 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 648999004777 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 648999004778 substrate binding site [chemical binding]; other site 648999004779 active site 648999004780 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 648999004781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999004782 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 648999004783 Chitin binding domain; Region: Chitin_bind_3; pfam03067 648999004784 Cellulose binding domain; Region: CBM_2; pfam00553 648999004785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999004786 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 648999004787 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 648999004788 SelR domain; Region: SelR; pfam01641 648999004789 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 648999004790 nucleotide binding site [chemical binding]; other site 648999004791 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999004792 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999004793 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999004794 Walker A/P-loop; other site 648999004795 ATP binding site [chemical binding]; other site 648999004796 Q-loop/lid; other site 648999004797 ABC transporter signature motif; other site 648999004798 Walker B; other site 648999004799 D-loop; other site 648999004800 H-loop/switch region; other site 648999004801 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999004802 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999004803 Walker A/P-loop; other site 648999004804 ATP binding site [chemical binding]; other site 648999004805 Q-loop/lid; other site 648999004806 ABC transporter signature motif; other site 648999004807 Walker B; other site 648999004808 D-loop; other site 648999004809 H-loop/switch region; other site 648999004810 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999004811 Coenzyme A binding pocket [chemical binding]; other site 648999004812 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999004813 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 648999004814 structural tetrad; other site 648999004815 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 648999004816 TAP-like protein; Region: Abhydrolase_4; pfam08386 648999004817 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 648999004818 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 648999004819 active site 648999004820 DNA binding site [nucleotide binding] 648999004821 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 648999004822 DNA binding site [nucleotide binding] 648999004823 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 648999004824 putative hydrophobic ligand binding site [chemical binding]; other site 648999004825 putative acetyltransferase; Provisional; Region: PRK03624 648999004826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004827 Coenzyme A binding pocket [chemical binding]; other site 648999004828 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 648999004829 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 648999004830 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 648999004831 helix-hairpin-helix signature motif; other site 648999004832 active site 648999004833 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 648999004834 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 648999004835 Putative zinc-finger; Region: zf-HC2; pfam13490 648999004836 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 648999004837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999004838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999004839 DNA binding residues [nucleotide binding] 648999004840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999004841 S-adenosylmethionine binding site [chemical binding]; other site 648999004842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 648999004843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004844 AAA domain; Region: AAA_23; pfam13476 648999004845 Walker A/P-loop; other site 648999004846 ATP binding site [chemical binding]; other site 648999004847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004848 Q-loop/lid; other site 648999004849 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 648999004850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999004851 ABC transporter signature motif; other site 648999004852 Walker B; other site 648999004853 D-loop; other site 648999004854 H-loop/switch region; other site 648999004855 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 648999004856 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 648999004857 active site 648999004858 metal binding site [ion binding]; metal-binding site 648999004859 DNA binding site [nucleotide binding] 648999004860 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 648999004861 HerA helicase [Replication, recombination, and repair]; Region: COG0433 648999004862 hypothetical protein; Provisional; Region: PRK14059 648999004863 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 648999004864 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 648999004865 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999004866 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999004867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 648999004868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999004869 ABC-ATPase subunit interface; other site 648999004870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999004871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999004872 dimer interface [polypeptide binding]; other site 648999004873 conserved gate region; other site 648999004874 putative PBP binding loops; other site 648999004875 ABC-ATPase subunit interface; other site 648999004876 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999004877 beta-galactosidase; Region: BGL; TIGR03356 648999004878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999004879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999004880 DNA binding site [nucleotide binding] 648999004881 domain linker motif; other site 648999004882 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 648999004883 putative dimerization interface [polypeptide binding]; other site 648999004884 putative ligand binding site [chemical binding]; other site 648999004885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999004886 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 648999004887 FAD binding site [chemical binding]; other site 648999004888 substrate binding site [chemical binding]; other site 648999004889 catalytic base [active] 648999004890 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 648999004891 putative active site [active] 648999004892 putative substrate binding site [chemical binding]; other site 648999004893 ATP binding site [chemical binding]; other site 648999004894 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 648999004895 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 648999004896 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 648999004897 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999004898 NAD(P) binding site [chemical binding]; other site 648999004899 catalytic residues [active] 648999004900 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 648999004901 endoglucanase; Region: PLN02308 648999004902 Cellulose binding domain; Region: CBM_3; cl03026 648999004903 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999004904 Interdomain contacts; other site 648999004905 Cellulose binding domain; Region: CBM_2; pfam00553 648999004906 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 648999004907 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999004908 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999004909 putative sugar binding sites [chemical binding]; other site 648999004910 Q-X-W motif; other site 648999004911 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 648999004912 active site 648999004913 Protein of unknown function, DUF488; Region: DUF488; pfam04343 648999004914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 648999004915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999004916 Coenzyme A binding pocket [chemical binding]; other site 648999004917 biotin synthase; Validated; Region: PRK06256 648999004918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999004919 FeS/SAM binding site; other site 648999004920 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 648999004921 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 648999004922 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 648999004923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999004924 catalytic residue [active] 648999004925 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 648999004926 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999004927 Cytochrome P450; Region: p450; cl12078 648999004928 Predicted methyltransferase [General function prediction only]; Region: COG3897 648999004929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999004930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999004931 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 648999004932 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 648999004933 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 648999004934 oligomerization interface [polypeptide binding]; other site 648999004935 active site 648999004936 metal binding site [ion binding]; metal-binding site 648999004937 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 648999004938 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999004939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999004940 NAD(P) binding site [chemical binding]; other site 648999004941 active site 648999004942 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 648999004943 dimer interface [polypeptide binding]; other site 648999004944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999004945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999004946 active site 648999004947 phosphorylation site [posttranslational modification] 648999004948 intermolecular recognition site; other site 648999004949 dimerization interface [polypeptide binding]; other site 648999004950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999004951 DNA binding residues [nucleotide binding] 648999004952 dimerization interface [polypeptide binding]; other site 648999004953 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999004954 GAF domain; Region: GAF; pfam01590 648999004955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999004956 Histidine kinase; Region: HisKA_3; pfam07730 648999004957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999004958 ATP binding site [chemical binding]; other site 648999004959 Mg2+ binding site [ion binding]; other site 648999004960 G-X-G motif; other site 648999004961 hypothetical protein; Provisional; Region: PRK07877 648999004962 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 648999004963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999004964 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 648999004965 Hemerythrin-like domain; Region: Hr-like; cd12108 648999004966 Fe binding site [ion binding]; other site 648999004967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999004968 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999004969 Ligand Binding Site [chemical binding]; other site 648999004970 putative phosphoketolase; Provisional; Region: PRK05261 648999004971 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 648999004972 TPP-binding site; other site 648999004973 XFP C-terminal domain; Region: XFP_C; pfam09363 648999004974 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999004975 Ligand Binding Site [chemical binding]; other site 648999004976 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 648999004977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 648999004978 Clp amino terminal domain; Region: Clp_N; pfam02861 648999004979 Clp amino terminal domain; Region: Clp_N; pfam02861 648999004980 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 648999004981 lipid kinase; Reviewed; Region: PRK13054 648999004982 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 648999004983 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 648999004984 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 648999004985 active site 648999004986 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 648999004987 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 648999004988 active site 648999004989 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999004990 putative catalytic site [active] 648999004991 putative metal binding site [ion binding]; other site 648999004992 putative phosphate binding site [ion binding]; other site 648999004993 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 648999004994 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999004995 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 648999004996 Cellulose binding domain; Region: CBM_2; pfam00553 648999004997 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 648999004998 Melibiase; Region: Melibiase; pfam02065 648999004999 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999005000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999005001 dimer interface [polypeptide binding]; other site 648999005002 conserved gate region; other site 648999005003 putative PBP binding loops; other site 648999005004 ABC-ATPase subunit interface; other site 648999005005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999005006 dimer interface [polypeptide binding]; other site 648999005007 conserved gate region; other site 648999005008 putative PBP binding loops; other site 648999005009 ABC-ATPase subunit interface; other site 648999005010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999005011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999005012 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 648999005013 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 648999005014 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 648999005015 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 648999005016 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 648999005017 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 648999005018 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 648999005019 SpoOM protein; Region: Spo0M; pfam07070 648999005020 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 648999005021 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 648999005022 Part of AAA domain; Region: AAA_19; pfam13245 648999005023 Family description; Region: UvrD_C_2; pfam13538 648999005024 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 648999005025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999005027 active site 648999005028 phosphorylation site [posttranslational modification] 648999005029 intermolecular recognition site; other site 648999005030 dimerization interface [polypeptide binding]; other site 648999005031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999005032 DNA binding site [nucleotide binding] 648999005033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999005034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999005035 dimerization interface [polypeptide binding]; other site 648999005036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999005037 dimer interface [polypeptide binding]; other site 648999005038 phosphorylation site [posttranslational modification] 648999005039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999005040 ATP binding site [chemical binding]; other site 648999005041 Mg2+ binding site [ion binding]; other site 648999005042 G-X-G motif; other site 648999005043 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999005044 Tetratricopeptide repeat; Region: TPR_10; pfam13374 648999005045 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999005046 MarR family; Region: MarR_2; cl17246 648999005047 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 648999005048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999005049 putative active site [active] 648999005050 putative metal binding site [ion binding]; other site 648999005051 Ion channel; Region: Ion_trans_2; pfam07885 648999005052 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 648999005053 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 648999005054 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 648999005055 FMN binding site [chemical binding]; other site 648999005056 dimer interface [polypeptide binding]; other site 648999005057 Predicted transcriptional regulator [Transcription]; Region: COG1959 648999005058 Transcriptional regulator; Region: Rrf2; pfam02082 648999005059 Helix-turn-helix domain; Region: HTH_18; pfam12833 648999005060 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 648999005061 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 648999005062 NADP binding site [chemical binding]; other site 648999005063 active site 648999005064 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 648999005065 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 648999005066 putative transposase OrfB; Reviewed; Region: PHA02517 648999005067 HTH-like domain; Region: HTH_21; pfam13276 648999005068 Integrase core domain; Region: rve; pfam00665 648999005069 Integrase core domain; Region: rve_3; pfam13683 648999005070 Transposase; Region: HTH_Tnp_1; pfam01527 648999005071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 648999005072 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 648999005073 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999005074 DinB superfamily; Region: DinB_2; pfam12867 648999005075 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 648999005076 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999005077 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999005078 DNA binding site [nucleotide binding] 648999005079 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999005080 Predicted ATPase [General function prediction only]; Region: COG3903 648999005081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999005082 Epoxide hydrolase N terminus; Region: EHN; pfam06441 648999005083 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999005084 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 648999005085 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 648999005086 putative active site [active] 648999005087 metal binding site [ion binding]; metal-binding site 648999005088 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 648999005089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999005090 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 648999005091 Predicted transcriptional regulator [Transcription]; Region: COG2378 648999005092 HTH domain; Region: HTH_11; pfam08279 648999005093 WYL domain; Region: WYL; pfam13280 648999005094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999005095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999005096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 648999005097 dimerization interface [polypeptide binding]; other site 648999005098 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 648999005099 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 648999005100 putative hydrophobic ligand binding site [chemical binding]; other site 648999005101 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999005102 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 648999005103 Ligand binding site; other site 648999005104 metal-binding site 648999005105 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 648999005106 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 648999005107 XdhC Rossmann domain; Region: XdhC_C; pfam13478 648999005108 metallochaperone-like domain; Region: TRASH; smart00746 648999005109 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 648999005110 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 648999005111 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 648999005112 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 648999005113 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 648999005114 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 648999005115 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 648999005116 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 648999005117 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 648999005118 XdhC Rossmann domain; Region: XdhC_C; pfam13478 648999005119 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999005120 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999005121 Walker A/P-loop; other site 648999005122 ATP binding site [chemical binding]; other site 648999005123 Q-loop/lid; other site 648999005124 ABC transporter signature motif; other site 648999005125 Walker B; other site 648999005126 D-loop; other site 648999005127 H-loop/switch region; other site 648999005128 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 648999005129 Phosphotransferase enzyme family; Region: APH; pfam01636 648999005130 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999005131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999005132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999005133 active site 648999005134 catalytic tetrad [active] 648999005135 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 648999005136 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 648999005137 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 648999005138 Mg++ binding site [ion binding]; other site 648999005139 putative catalytic motif [active] 648999005140 putative substrate binding site [chemical binding]; other site 648999005141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999005142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999005143 putative DNA binding site [nucleotide binding]; other site 648999005144 putative Zn2+ binding site [ion binding]; other site 648999005145 hypothetical protein; Provisional; Region: PRK07236 648999005146 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 648999005147 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999005148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999005149 Cupin domain; Region: Cupin_2; cl17218 648999005150 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 648999005151 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 648999005152 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999005153 Interdomain contacts; other site 648999005154 Cytokine receptor motif; other site 648999005155 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999005156 Interdomain contacts; other site 648999005157 Cytokine receptor motif; other site 648999005158 Cellulose binding domain; Region: CBM_2; pfam00553 648999005159 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 648999005160 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 648999005161 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999005162 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999005163 Interdomain contacts; other site 648999005164 Cytokine receptor motif; other site 648999005165 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 648999005166 putative hydrophobic ligand binding site [chemical binding]; other site 648999005167 Cellulose binding domain; Region: CBM_2; pfam00553 648999005168 Helix-turn-helix domain; Region: HTH_31; pfam13560 648999005169 short chain dehydrogenase; Provisional; Region: PRK12939 648999005170 classical (c) SDRs; Region: SDR_c; cd05233 648999005171 NAD(P) binding site [chemical binding]; other site 648999005172 active site 648999005173 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 648999005174 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 648999005175 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 648999005176 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 648999005177 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 648999005178 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 648999005179 Ligand binding site; other site 648999005180 Putative Catalytic site; other site 648999005181 DXD motif; other site 648999005182 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999005183 DinB superfamily; Region: DinB_2; pfam12867 648999005184 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 648999005185 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 648999005186 active site 648999005187 catalytic triad [active] 648999005188 oxyanion hole [active] 648999005189 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999005190 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999005191 putative sugar binding sites [chemical binding]; other site 648999005192 Q-X-W motif; other site 648999005193 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 648999005194 substrate binding site [chemical binding]; other site 648999005195 active site 648999005196 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 648999005197 metal binding site [ion binding]; metal-binding site 648999005198 ligand binding site [chemical binding]; other site 648999005199 Cellulose binding domain; Region: CBM_2; pfam00553 648999005200 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 648999005201 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999005202 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999005203 putative sugar binding sites [chemical binding]; other site 648999005204 Q-X-W motif; other site 648999005205 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 648999005206 Cellulose binding domain; Region: CBM_2; pfam00553 648999005207 MarR family; Region: MarR_2; pfam12802 648999005208 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999005209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999005210 nucleotide binding site [chemical binding]; other site 648999005211 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999005212 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 648999005213 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 648999005214 active site 648999005215 substrate binding pocket [chemical binding]; other site 648999005216 homodimer interaction site [polypeptide binding]; other site 648999005217 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999005218 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999005219 nucleotide binding site [chemical binding]; other site 648999005220 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999005221 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999005222 TM-ABC transporter signature motif; other site 648999005223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 648999005224 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 648999005225 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999005226 catalytic residue [active] 648999005227 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999005228 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999005229 Walker A/P-loop; other site 648999005230 ATP binding site [chemical binding]; other site 648999005231 Q-loop/lid; other site 648999005232 ABC transporter signature motif; other site 648999005233 Walker B; other site 648999005234 D-loop; other site 648999005235 H-loop/switch region; other site 648999005236 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 648999005237 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999005238 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999005239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999005240 dimer interface [polypeptide binding]; other site 648999005241 conserved gate region; other site 648999005242 putative PBP binding loops; other site 648999005243 ABC-ATPase subunit interface; other site 648999005244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999005245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999005246 dimer interface [polypeptide binding]; other site 648999005247 conserved gate region; other site 648999005248 putative PBP binding loops; other site 648999005249 ABC-ATPase subunit interface; other site 648999005250 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999005251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999005252 Walker A/P-loop; other site 648999005253 ATP binding site [chemical binding]; other site 648999005254 Q-loop/lid; other site 648999005255 ABC transporter signature motif; other site 648999005256 Walker B; other site 648999005257 D-loop; other site 648999005258 H-loop/switch region; other site 648999005259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 648999005260 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999005261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999005262 Walker A/P-loop; other site 648999005263 ATP binding site [chemical binding]; other site 648999005264 Q-loop/lid; other site 648999005265 ABC transporter signature motif; other site 648999005266 Walker B; other site 648999005267 D-loop; other site 648999005268 H-loop/switch region; other site 648999005269 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 648999005270 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 648999005271 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 648999005272 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 648999005273 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 648999005274 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 648999005275 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 648999005276 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 648999005277 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 648999005278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999005279 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 648999005280 active site 648999005281 SnoaL-like domain; Region: SnoaL_3; pfam13474 648999005282 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999005283 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999005284 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 648999005285 NAD(P) binding site [chemical binding]; other site 648999005286 TIGR04076 family protein; Region: TIGR04076 648999005287 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 648999005288 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999005289 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 648999005290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999005291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999005292 non-specific DNA binding site [nucleotide binding]; other site 648999005293 salt bridge; other site 648999005294 sequence-specific DNA binding site [nucleotide binding]; other site 648999005295 Cupin domain; Region: Cupin_2; pfam07883 648999005296 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999005297 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999005298 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999005299 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 648999005300 Walker A/P-loop; other site 648999005301 ATP binding site [chemical binding]; other site 648999005302 Q-loop/lid; other site 648999005303 ABC transporter signature motif; other site 648999005304 Walker B; other site 648999005305 D-loop; other site 648999005306 H-loop/switch region; other site 648999005307 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999005308 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999005309 DNA binding site [nucleotide binding] 648999005310 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999005311 Predicted ATPase [General function prediction only]; Region: COG3903 648999005312 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999005313 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999005314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999005315 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999005316 Walker A/P-loop; other site 648999005317 ATP binding site [chemical binding]; other site 648999005318 Q-loop/lid; other site 648999005319 ABC transporter signature motif; other site 648999005320 Walker B; other site 648999005321 D-loop; other site 648999005322 H-loop/switch region; other site 648999005323 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 648999005324 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 648999005325 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 648999005326 putative active site [active] 648999005327 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 648999005328 putative dimer interface [polypeptide binding]; other site 648999005329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999005330 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 648999005331 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999005332 RibD C-terminal domain; Region: RibD_C; cl17279 648999005333 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 648999005334 active site residue [active] 648999005335 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 648999005336 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 648999005337 conserved cys residue [active] 648999005338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999005339 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999005340 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 648999005341 putative hydrophobic ligand binding site [chemical binding]; other site 648999005342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999005343 dimerization interface [polypeptide binding]; other site 648999005344 putative DNA binding site [nucleotide binding]; other site 648999005345 putative Zn2+ binding site [ion binding]; other site 648999005346 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 648999005347 hydroxyglutarate oxidase; Provisional; Region: PRK11728 648999005348 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 648999005349 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 648999005350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999005351 active site 648999005352 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999005353 RibD C-terminal domain; Region: RibD_C; cl17279 648999005354 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 648999005355 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 648999005356 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999005357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999005358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 648999005359 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 648999005360 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999005361 substrate binding site [chemical binding]; other site 648999005362 ATP binding site [chemical binding]; other site 648999005363 Survival protein SurE; Region: SurE; cl00448 648999005364 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999005365 RNA polymerase factor sigma-70; Validated; Region: PRK08241 648999005366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999005367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999005368 DNA binding residues [nucleotide binding] 648999005369 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999005370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999005371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999005372 DNA binding site [nucleotide binding] 648999005373 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 648999005374 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999005375 active site 648999005376 catalytic residues [active] 648999005377 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 648999005378 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 648999005379 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 648999005380 Kelch motif; Region: Kelch_1; pfam01344 648999005381 Kelch motif; Region: Kelch_1; pfam01344 648999005382 Kelch domain; Region: Kelch; smart00612 648999005383 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 648999005384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999005385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999005386 DNA binding site [nucleotide binding] 648999005387 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999005388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999005389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999005390 DNA binding residues [nucleotide binding] 648999005391 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 648999005392 Protein of unknown function DUF72; Region: DUF72; pfam01904 648999005393 RF-1 domain; Region: RF-1; cl17422 648999005394 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 648999005395 hypothetical protein; Reviewed; Region: PRK09588 648999005396 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 648999005397 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 648999005398 active site 648999005399 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 648999005400 Glyco_18 domain; Region: Glyco_18; smart00636 648999005401 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 648999005402 active site 648999005403 Ricin-type beta-trefoil; Region: RICIN; smart00458 648999005404 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999005405 putative sugar binding sites [chemical binding]; other site 648999005406 Q-X-W motif; other site 648999005407 hydroperoxidase II; Provisional; Region: katE; PRK11249 648999005408 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 648999005409 heme binding pocket [chemical binding]; other site 648999005410 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 648999005411 conserved cys residue [active] 648999005412 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 648999005413 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 648999005414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999005415 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999005416 active site 648999005417 metal binding site [ion binding]; metal-binding site 648999005418 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 648999005419 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 648999005420 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 648999005421 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999005422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999005423 ATP binding site [chemical binding]; other site 648999005424 Mg2+ binding site [ion binding]; other site 648999005425 G-X-G motif; other site 648999005426 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 648999005427 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999005428 anti sigma factor interaction site; other site 648999005429 regulatory phosphorylation site [posttranslational modification]; other site 648999005430 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 648999005431 DinB superfamily; Region: DinB_2; pfam12867 648999005432 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999005433 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 648999005434 SCP-2 sterol transfer family; Region: SCP2; pfam02036 648999005435 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 648999005436 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 648999005437 Protein of unknown function DUF72; Region: DUF72; pfam01904 648999005438 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 648999005439 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 648999005440 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 648999005441 heme-binding site [chemical binding]; other site 648999005442 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 648999005443 FAD binding pocket [chemical binding]; other site 648999005444 FAD binding motif [chemical binding]; other site 648999005445 phosphate binding motif [ion binding]; other site 648999005446 beta-alpha-beta structure motif; other site 648999005447 NAD binding pocket [chemical binding]; other site 648999005448 Heme binding pocket [chemical binding]; other site 648999005449 Transcriptional regulator; Region: Rrf2; cl17282 648999005450 Rrf2 family protein; Region: rrf2_super; TIGR00738 648999005451 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999005452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999005453 S-adenosylmethionine binding site [chemical binding]; other site 648999005454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999005455 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 648999005456 active site 648999005457 oxyanion hole [active] 648999005458 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 648999005459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999005460 ATP binding site [chemical binding]; other site 648999005461 Mg2+ binding site [ion binding]; other site 648999005462 G-X-G motif; other site 648999005463 DNA gyrase B; Region: DNA_gyraseB; pfam00204 648999005464 ATP binding site [chemical binding]; other site 648999005465 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 648999005466 active site 648999005467 metal binding site [ion binding]; metal-binding site 648999005468 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 648999005469 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 648999005470 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 648999005471 CAP-like domain; other site 648999005472 active site 648999005473 primary dimer interface [polypeptide binding]; other site 648999005474 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 648999005475 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 648999005476 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 648999005477 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 648999005478 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 648999005479 Acyltransferase family; Region: Acyl_transf_3; pfam01757 648999005480 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999005481 putative active site [active] 648999005482 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999005483 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 648999005484 substrate binding site; other site 648999005485 dimer interface; other site 648999005486 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999005487 classical (c) SDRs; Region: SDR_c; cd05233 648999005488 NAD(P) binding site [chemical binding]; other site 648999005489 active site 648999005490 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 648999005491 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999005492 Walker A/P-loop; other site 648999005493 ATP binding site [chemical binding]; other site 648999005494 Q-loop/lid; other site 648999005495 ABC transporter signature motif; other site 648999005496 Walker B; other site 648999005497 D-loop; other site 648999005498 H-loop/switch region; other site 648999005499 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 648999005500 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999005501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005503 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 648999005504 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 648999005505 inhibitor-cofactor binding pocket; inhibition site 648999005506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999005507 catalytic residue [active] 648999005508 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999005509 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999005510 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999005511 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005512 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999005513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005514 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005519 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005520 putative glycosyl transferase; Provisional; Region: PRK10073 648999005521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999005522 active site 648999005523 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 648999005524 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 648999005525 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 648999005526 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 648999005527 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 648999005528 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 648999005529 putative trimer interface [polypeptide binding]; other site 648999005530 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 648999005531 putative CoA binding site [chemical binding]; other site 648999005532 putative trimer interface [polypeptide binding]; other site 648999005533 putative active site [active] 648999005534 putative substrate binding site [chemical binding]; other site 648999005535 putative CoA binding site [chemical binding]; other site 648999005536 Protein of unknown function (DUF952); Region: DUF952; pfam06108 648999005537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999005538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999005539 active site 648999005540 phosphorylation site [posttranslational modification] 648999005541 intermolecular recognition site; other site 648999005542 dimerization interface [polypeptide binding]; other site 648999005543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999005544 DNA binding site [nucleotide binding] 648999005545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999005546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999005547 dimer interface [polypeptide binding]; other site 648999005548 phosphorylation site [posttranslational modification] 648999005549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999005550 ATP binding site [chemical binding]; other site 648999005551 Mg2+ binding site [ion binding]; other site 648999005552 G-X-G motif; other site 648999005553 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 648999005554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999005555 substrate binding pocket [chemical binding]; other site 648999005556 membrane-bound complex binding site; other site 648999005557 hypothetical protein; Validated; Region: PRK02101 648999005558 Uncharacterized conserved protein [Function unknown]; Region: COG4850 648999005559 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 648999005560 glycogen branching enzyme; Provisional; Region: PRK05402 648999005561 Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Region: CBM_48; pfam02922 648999005562 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 648999005563 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 648999005564 active site 648999005565 catalytic site [active] 648999005566 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 648999005567 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 648999005568 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 648999005569 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 648999005570 active site 648999005571 homodimer interface [polypeptide binding]; other site 648999005572 catalytic site [active] 648999005573 acceptor binding site [chemical binding]; other site 648999005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999005575 S-adenosylmethionine binding site [chemical binding]; other site 648999005576 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 648999005577 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999005578 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 648999005579 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 648999005580 ligand binding site; other site 648999005581 oligomer interface; other site 648999005582 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 648999005583 dimer interface [polypeptide binding]; other site 648999005584 N-terminal domain interface [polypeptide binding]; other site 648999005585 sulfate 1 binding site; other site 648999005586 phosphoglucomutase; Validated; Region: PRK07564 648999005587 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 648999005588 active site 648999005589 substrate binding site [chemical binding]; other site 648999005590 metal binding site [ion binding]; metal-binding site 648999005591 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 648999005592 ATP-NAD kinase; Region: NAD_kinase; pfam01513 648999005593 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 648999005594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999005595 active site 648999005596 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999005597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999005598 NAD(P) binding site [chemical binding]; other site 648999005599 active site 648999005600 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 648999005601 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 648999005602 NAD binding site [chemical binding]; other site 648999005603 substrate binding site [chemical binding]; other site 648999005604 active site 648999005605 O-Antigen ligase; Region: Wzy_C; pfam04932 648999005606 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 648999005607 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005609 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005611 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999005612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999005613 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 648999005614 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 648999005615 inhibitor-cofactor binding pocket; inhibition site 648999005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999005617 catalytic residue [active] 648999005618 Domain of unknown function (DUF389); Region: DUF389; cl00781 648999005619 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 648999005620 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 648999005621 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 648999005622 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 648999005623 RNA binding site [nucleotide binding]; other site 648999005624 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 648999005625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999005626 Zn2+ binding site [ion binding]; other site 648999005627 Mg2+ binding site [ion binding]; other site 648999005628 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 648999005629 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 648999005630 putative trimer interface [polypeptide binding]; other site 648999005631 putative CoA binding site [chemical binding]; other site 648999005632 Bacterial sugar transferase; Region: Bac_transf; pfam02397 648999005633 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999005634 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 648999005635 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 648999005636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999005637 NAD(P) binding site [chemical binding]; other site 648999005638 active site 648999005639 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 648999005640 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 648999005641 NAD binding site [chemical binding]; other site 648999005642 catalytic Zn binding site [ion binding]; other site 648999005643 structural Zn binding site [ion binding]; other site 648999005644 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 648999005645 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 648999005646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999005647 NAD(P) binding site [chemical binding]; other site 648999005648 active site 648999005649 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 648999005650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999005651 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 648999005652 acyl-activating enzyme (AAE) consensus motif; other site 648999005653 acyl-activating enzyme (AAE) consensus motif; other site 648999005654 putative AMP binding site [chemical binding]; other site 648999005655 putative active site [active] 648999005656 putative CoA binding site [chemical binding]; other site 648999005657 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 648999005658 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 648999005659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005667 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 648999005668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999005669 dimer interface [polypeptide binding]; other site 648999005670 active site 648999005671 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 648999005672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999005673 substrate binding site [chemical binding]; other site 648999005674 oxyanion hole (OAH) forming residues; other site 648999005675 trimer interface [polypeptide binding]; other site 648999005676 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999005677 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999005678 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 648999005679 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 648999005680 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 648999005681 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 648999005682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999005683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999005684 active site 648999005685 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999005686 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 648999005687 NAD(P) binding site [chemical binding]; other site 648999005688 catalytic residues [active] 648999005689 Transcriptional regulators [Transcription]; Region: GntR; COG1802 648999005690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999005691 DNA-binding site [nucleotide binding]; DNA binding site 648999005692 enoyl-CoA hydratase; Provisional; Region: PRK06210 648999005693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999005694 substrate binding site [chemical binding]; other site 648999005695 oxyanion hole (OAH) forming residues; other site 648999005696 trimer interface [polypeptide binding]; other site 648999005697 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 648999005698 CoA-transferase family III; Region: CoA_transf_3; pfam02515 648999005699 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 648999005700 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999005701 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999005702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999005703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999005704 active site 648999005705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999005706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999005707 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 648999005708 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 648999005709 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 648999005710 L-aspartate oxidase; Provisional; Region: PRK06175 648999005711 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 648999005712 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 648999005713 proximal heme binding site [chemical binding]; other site 648999005714 distal heme binding site [chemical binding]; other site 648999005715 putative dimer interface [polypeptide binding]; other site 648999005716 putative Iron-sulfur protein interface [polypeptide binding]; other site 648999005717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999005718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999005719 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 648999005720 dimerization interface [polypeptide binding]; other site 648999005721 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 648999005722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999005723 ATP binding site [chemical binding]; other site 648999005724 putative Mg++ binding site [ion binding]; other site 648999005725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999005726 nucleotide binding region [chemical binding]; other site 648999005727 ATP-binding site [chemical binding]; other site 648999005728 Helicase associated domain (HA2); Region: HA2; pfam04408 648999005729 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 648999005730 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 648999005731 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 648999005732 active site 648999005733 catalytic motif [active] 648999005734 Zn binding site [ion binding]; other site 648999005735 YCII-related domain; Region: YCII; cl00999 648999005736 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 648999005737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999005738 DNA binding residues [nucleotide binding] 648999005739 dimer interface [polypeptide binding]; other site 648999005740 FecCD transport family; Region: FecCD; pfam01032 648999005741 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 648999005742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999005743 putative PBP binding regions; other site 648999005744 ABC-ATPase subunit interface; other site 648999005745 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999005746 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 648999005747 Walker A/P-loop; other site 648999005748 ATP binding site [chemical binding]; other site 648999005749 Q-loop/lid; other site 648999005750 ABC transporter signature motif; other site 648999005751 Walker B; other site 648999005752 D-loop; other site 648999005753 H-loop/switch region; other site 648999005754 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 648999005755 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 648999005756 siderophore binding site; other site 648999005757 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 648999005758 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 648999005759 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 648999005760 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999005761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999005762 ATP binding site [chemical binding]; other site 648999005763 putative Mg++ binding site [ion binding]; other site 648999005764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999005765 nucleotide binding region [chemical binding]; other site 648999005766 ATP-binding site [chemical binding]; other site 648999005767 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 648999005768 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 648999005769 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 648999005770 active site 648999005771 putative catalytic site [active] 648999005772 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 648999005773 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 648999005774 catalytic residues [active] 648999005775 catalytic nucleophile [active] 648999005776 Recombinase; Region: Recombinase; pfam07508 648999005777 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 648999005778 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 648999005779 nucleotide binding site [chemical binding]; other site 648999005780 AAA domain; Region: AAA_25; pfam13481 648999005781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999005782 ATP binding site [chemical binding]; other site 648999005783 Walker B motif; other site 648999005784 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 648999005785 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999005786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999005787 DNA-binding site [nucleotide binding]; DNA binding site 648999005788 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 648999005789 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999005790 putative catalytic site [active] 648999005791 putative metal binding site [ion binding]; other site 648999005792 putative phosphate binding site [ion binding]; other site 648999005793 PAC2 family; Region: PAC2; pfam09754 648999005794 EcsC protein family; Region: EcsC; pfam12787 648999005795 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 648999005796 active site 648999005797 catalytic triad [active] 648999005798 oxyanion hole [active] 648999005799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 648999005800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999005801 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 648999005802 NAD(P) binding site [chemical binding]; other site 648999005803 catalytic residues [active] 648999005804 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999005805 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 648999005806 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 648999005807 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 648999005808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999005809 DinB superfamily; Region: DinB_2; pfam12867 648999005810 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 648999005811 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 648999005812 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 648999005813 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 648999005814 Cellulose binding domain; Region: CBM_2; pfam00553 648999005815 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 648999005816 active site 648999005817 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 648999005818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999005819 putative Mg++ binding site [ion binding]; other site 648999005820 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 648999005821 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 648999005822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999005823 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999005824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999005825 DNA binding residues [nucleotide binding] 648999005826 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 648999005827 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 648999005828 putative active site [active] 648999005829 catalytic site [active] 648999005830 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 648999005831 putative active site [active] 648999005832 catalytic site [active] 648999005833 Pirin-related protein [General function prediction only]; Region: COG1741 648999005834 Pirin; Region: Pirin; pfam02678 648999005835 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 648999005836 MarR family; Region: MarR_2; pfam12802 648999005837 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999005838 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 648999005839 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 648999005840 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 648999005841 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 648999005842 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 648999005843 active site 648999005844 metal binding site [ion binding]; metal-binding site 648999005845 homotetramer interface [polypeptide binding]; other site 648999005846 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 648999005847 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 648999005848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999005849 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 648999005850 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 648999005851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999005852 motif II; other site 648999005853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999005854 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 648999005855 GAF domain; Region: GAF_3; pfam13492 648999005856 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999005857 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999005858 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999005859 Conserved TM helix; Region: TM_helix; pfam05552 648999005860 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 648999005861 putative hydrophobic ligand binding site [chemical binding]; other site 648999005862 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 648999005863 ChaB; Region: ChaB; pfam06150 648999005864 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 648999005865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999005866 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 648999005867 NAD(P) binding site [chemical binding]; other site 648999005868 catalytic residues [active] 648999005869 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 648999005870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999005871 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 648999005872 Ligand binding site; other site 648999005873 Putative Catalytic site; other site 648999005874 DXD motif; other site 648999005875 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 648999005876 hydrophobic ligand binding site; other site 648999005877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999005878 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 648999005879 active site 648999005880 motif I; other site 648999005881 motif II; other site 648999005882 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 648999005883 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 648999005884 putative active site [active] 648999005885 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999005886 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 648999005887 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 648999005888 putative ADP-binding pocket [chemical binding]; other site 648999005889 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 648999005890 dimer interface [polypeptide binding]; other site 648999005891 active site 648999005892 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 648999005893 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999005894 substrate binding site [chemical binding]; other site 648999005895 ATP binding site [chemical binding]; other site 648999005896 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 648999005897 active site 648999005898 nucleotide binding site [chemical binding]; other site 648999005899 HIGH motif; other site 648999005900 KMSKS motif; other site 648999005901 classical (c) SDRs; Region: SDR_c; cd05233 648999005902 NAD(P) binding site [chemical binding]; other site 648999005903 active site 648999005904 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 648999005905 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 648999005906 putative active site [active] 648999005907 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 648999005908 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 648999005909 active site 648999005910 DNA binding site [nucleotide binding] 648999005911 Int/Topo IB signature motif; other site 648999005912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999005913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999005914 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999005915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999005916 ATP binding site [chemical binding]; other site 648999005917 putative Mg++ binding site [ion binding]; other site 648999005918 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 648999005919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999005920 nucleotide binding region [chemical binding]; other site 648999005921 ATP-binding site [chemical binding]; other site 648999005922 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 648999005923 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 648999005924 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 648999005925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999005926 Coenzyme A binding pocket [chemical binding]; other site 648999005927 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999005928 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999005929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999005930 catalytic residue [active] 648999005931 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 648999005932 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 648999005933 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 648999005934 Mechanosensitive ion channel; Region: MS_channel; pfam00924 648999005935 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 648999005936 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 648999005937 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 648999005938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999005939 DNA-binding site [nucleotide binding]; DNA binding site 648999005940 RNA-binding motif; other site 648999005941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999005942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999005943 active site 648999005944 catalytic tetrad [active] 648999005945 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 648999005946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999005947 S-adenosylmethionine binding site [chemical binding]; other site 648999005948 adenosine deaminase; Provisional; Region: PRK09358 648999005949 active site 648999005950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999005951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999005952 dimerization interface [polypeptide binding]; other site 648999005953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999005954 dimer interface [polypeptide binding]; other site 648999005955 phosphorylation site [posttranslational modification] 648999005956 ATP binding site [chemical binding]; other site 648999005957 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 648999005958 Mg2+ binding site [ion binding]; other site 648999005959 G-X-G motif; other site 648999005960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999005962 active site 648999005963 phosphorylation site [posttranslational modification] 648999005964 intermolecular recognition site; other site 648999005965 dimerization interface [polypeptide binding]; other site 648999005966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999005967 DNA binding site [nucleotide binding] 648999005968 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 648999005969 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 648999005970 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 648999005971 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 648999005972 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 648999005973 active site 648999005974 dimer interface [polypeptide binding]; other site 648999005975 motif 1; other site 648999005976 motif 2; other site 648999005977 motif 3; other site 648999005978 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 648999005979 anticodon binding site; other site 648999005980 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 648999005981 nucleotide binding site/active site [active] 648999005982 HIT family signature motif; other site 648999005983 catalytic residue [active] 648999005984 glycogen branching enzyme; Provisional; Region: PRK14705 648999005985 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999005986 active site 648999005987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999005988 catalytic tetrad [active] 648999005989 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 648999005990 elongation factor G; Reviewed; Region: PRK12740 648999005991 G1 box; other site 648999005992 putative GEF interaction site [polypeptide binding]; other site 648999005993 GTP/Mg2+ binding site [chemical binding]; other site 648999005994 Switch I region; other site 648999005995 G2 box; other site 648999005996 G3 box; other site 648999005997 Switch II region; other site 648999005998 G4 box; other site 648999005999 G5 box; other site 648999006000 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 648999006001 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 648999006002 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 648999006003 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 648999006004 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 648999006005 putative acyl-acceptor binding pocket; other site 648999006006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999006007 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999006008 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 648999006009 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 648999006010 active site 648999006011 multimer interface [polypeptide binding]; other site 648999006012 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 648999006013 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 648999006014 predicted active site [active] 648999006015 catalytic triad [active] 648999006016 hypothetical protein; Validated; Region: PRK00110 648999006017 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999006018 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 648999006019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999006020 Walker A/P-loop; other site 648999006021 ATP binding site [chemical binding]; other site 648999006022 Q-loop/lid; other site 648999006023 ABC transporter signature motif; other site 648999006024 Walker B; other site 648999006025 D-loop; other site 648999006026 H-loop/switch region; other site 648999006027 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 648999006028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999006029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999006030 active site 648999006031 phosphorylation site [posttranslational modification] 648999006032 intermolecular recognition site; other site 648999006033 dimerization interface [polypeptide binding]; other site 648999006034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999006035 DNA binding residues [nucleotide binding] 648999006036 dimerization interface [polypeptide binding]; other site 648999006037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999006038 Histidine kinase; Region: HisKA_3; pfam07730 648999006039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999006040 ATP binding site [chemical binding]; other site 648999006041 Mg2+ binding site [ion binding]; other site 648999006042 G-X-G motif; other site 648999006043 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999006044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999006045 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 648999006046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999006047 active site 648999006048 ATP binding site [chemical binding]; other site 648999006049 substrate binding site [chemical binding]; other site 648999006050 activation loop (A-loop); other site 648999006051 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999006052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999006053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999006054 DNA binding residues [nucleotide binding] 648999006055 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999006056 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999006057 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 648999006058 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 648999006059 active site 648999006060 PHP Thumb interface [polypeptide binding]; other site 648999006061 metal binding site [ion binding]; metal-binding site 648999006062 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 648999006063 generic binding surface II; other site 648999006064 generic binding surface I; other site 648999006065 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 648999006066 amidase catalytic site [active] 648999006067 Zn binding residues [ion binding]; other site 648999006068 substrate binding site [chemical binding]; other site 648999006069 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 648999006070 putative metal binding site [ion binding]; other site 648999006071 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999006072 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999006073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999006074 catalytic residue [active] 648999006075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999006076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999006077 active site 648999006078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999006079 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999006080 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 648999006081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999006082 NAD binding site [chemical binding]; other site 648999006083 catalytic residues [active] 648999006084 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 648999006085 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 648999006086 NAD binding site [chemical binding]; other site 648999006087 catalytic Zn binding site [ion binding]; other site 648999006088 substrate binding site [chemical binding]; other site 648999006089 structural Zn binding site [ion binding]; other site 648999006090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999006091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999006092 hypothetical protein; Provisional; Region: PRK07236 648999006093 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 648999006094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999006097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999006098 GAF domain; Region: GAF_2; pfam13185 648999006099 GAF domain; Region: GAF; pfam01590 648999006100 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999006101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999006102 NAD(P) binding site [chemical binding]; other site 648999006103 active site 648999006104 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 648999006105 active site 648999006106 putative DNA-binding cleft [nucleotide binding]; other site 648999006107 dimer interface [polypeptide binding]; other site 648999006108 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 648999006109 RuvA N terminal domain; Region: RuvA_N; pfam01330 648999006110 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 648999006111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006112 Walker A motif; other site 648999006113 ATP binding site [chemical binding]; other site 648999006114 Walker B motif; other site 648999006115 arginine finger; other site 648999006116 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 648999006117 Preprotein translocase subunit; Region: YajC; pfam02699 648999006118 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 648999006119 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 648999006120 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 648999006121 Protein export membrane protein; Region: SecD_SecF; cl14618 648999006122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999006123 active site 648999006124 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 648999006125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999006126 Zn2+ binding site [ion binding]; other site 648999006127 Mg2+ binding site [ion binding]; other site 648999006128 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 648999006129 synthetase active site [active] 648999006130 NTP binding site [chemical binding]; other site 648999006131 metal binding site [ion binding]; metal-binding site 648999006132 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 648999006133 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 648999006134 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 648999006135 active site 648999006136 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 648999006137 active site 648999006138 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 648999006139 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 648999006140 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 648999006141 dimer interface [polypeptide binding]; other site 648999006142 motif 1; other site 648999006143 active site 648999006144 motif 2; other site 648999006145 motif 3; other site 648999006146 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 648999006147 anticodon binding site; other site 648999006148 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 648999006149 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 648999006150 homodimer interface [polypeptide binding]; other site 648999006151 putative substrate binding pocket [chemical binding]; other site 648999006152 diiron center [ion binding]; other site 648999006153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 648999006154 CoenzymeA binding site [chemical binding]; other site 648999006155 subunit interaction site [polypeptide binding]; other site 648999006156 PHB binding site; other site 648999006157 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999006158 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999006159 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 648999006160 Protein of unknown function (DUF998); Region: DUF998; pfam06197 648999006161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 648999006162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 648999006163 dimer interface [polypeptide binding]; other site 648999006164 anticodon binding site; other site 648999006165 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 648999006166 homodimer interface [polypeptide binding]; other site 648999006167 motif 1; other site 648999006168 active site 648999006169 motif 2; other site 648999006170 GAD domain; Region: GAD; pfam02938 648999006171 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 648999006172 motif 3; other site 648999006173 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 648999006174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999006175 NAD(P) binding site [chemical binding]; other site 648999006176 active site 648999006177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999006178 putative DNA binding site [nucleotide binding]; other site 648999006179 dimerization interface [polypeptide binding]; other site 648999006180 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999006181 putative Zn2+ binding site [ion binding]; other site 648999006182 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 648999006183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999006184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999006186 recombination factor protein RarA; Reviewed; Region: PRK13342 648999006187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006188 Walker A motif; other site 648999006189 ATP binding site [chemical binding]; other site 648999006190 Walker B motif; other site 648999006191 arginine finger; other site 648999006192 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 648999006193 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 648999006194 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 648999006195 motif 1; other site 648999006196 active site 648999006197 motif 2; other site 648999006198 motif 3; other site 648999006199 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 648999006200 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 648999006201 YceG-like family; Region: YceG; pfam02618 648999006202 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 648999006203 dimerization interface [polypeptide binding]; other site 648999006204 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 648999006205 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 648999006206 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 648999006207 NAD(P) binding site [chemical binding]; other site 648999006208 shikimate binding site; other site 648999006209 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 648999006210 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 648999006211 Tetramer interface [polypeptide binding]; other site 648999006212 active site 648999006213 FMN-binding site [chemical binding]; other site 648999006214 shikimate kinase; Reviewed; Region: aroK; PRK00131 648999006215 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 648999006216 ADP binding site [chemical binding]; other site 648999006217 magnesium binding site [ion binding]; other site 648999006218 putative shikimate binding site; other site 648999006219 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 648999006220 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 648999006221 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 648999006222 active site 648999006223 dimer interface [polypeptide binding]; other site 648999006224 metal binding site [ion binding]; metal-binding site 648999006225 Dehydroquinase class II; Region: DHquinase_II; pfam01220 648999006226 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 648999006227 trimer interface [polypeptide binding]; other site 648999006228 active site 648999006229 dimer interface [polypeptide binding]; other site 648999006230 elongation factor P; Validated; Region: PRK00529 648999006231 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 648999006232 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 648999006233 RNA binding site [nucleotide binding]; other site 648999006234 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 648999006235 RNA binding site [nucleotide binding]; other site 648999006236 transcription antitermination factor NusB; Region: nusB; TIGR01951 648999006237 putative RNA binding site [nucleotide binding]; other site 648999006238 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999006239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999006240 non-specific DNA binding site [nucleotide binding]; other site 648999006241 salt bridge; other site 648999006242 sequence-specific DNA binding site [nucleotide binding]; other site 648999006243 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 648999006244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999006245 active site 648999006246 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 648999006247 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 648999006248 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 648999006249 dihydroorotase; Validated; Region: pyrC; PRK09357 648999006250 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999006251 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 648999006252 active site 648999006253 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 648999006254 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 648999006255 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 648999006256 catalytic site [active] 648999006257 subunit interface [polypeptide binding]; other site 648999006258 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 648999006259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999006260 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999006261 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 648999006262 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999006263 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999006264 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 648999006265 IMP binding site; other site 648999006266 dimer interface [polypeptide binding]; other site 648999006267 interdomain contacts; other site 648999006268 partial ornithine binding site; other site 648999006269 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 648999006270 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 648999006271 quinone interaction residues [chemical binding]; other site 648999006272 active site 648999006273 catalytic residues [active] 648999006274 FMN binding site [chemical binding]; other site 648999006275 substrate binding site [chemical binding]; other site 648999006276 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 648999006277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999006278 inhibitor-cofactor binding pocket; inhibition site 648999006279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999006280 catalytic residue [active] 648999006281 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 648999006282 active site 648999006283 dimer interface [polypeptide binding]; other site 648999006284 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 648999006285 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999006286 active site 648999006287 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 648999006288 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 648999006289 Flavoprotein; Region: Flavoprotein; pfam02441 648999006290 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 648999006291 S-adenosylmethionine synthetase; Validated; Region: PRK05250 648999006292 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 648999006293 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 648999006294 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 648999006295 primosome assembly protein PriA; Provisional; Region: PRK14873 648999006296 cytidylate kinase; Provisional; Region: PRK04182 648999006297 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 648999006298 CMP-binding site; other site 648999006299 The sites determining sugar specificity; other site 648999006300 ParB-like nuclease domain; Region: ParBc; cl02129 648999006301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999006302 Cytochrome P450; Region: p450; cl12078 648999006303 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 648999006304 active site 648999006305 catalytic residues [active] 648999006306 metal binding site [ion binding]; metal-binding site 648999006307 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 648999006308 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 648999006309 putative active site [active] 648999006310 substrate binding site [chemical binding]; other site 648999006311 putative cosubstrate binding site; other site 648999006312 catalytic site [active] 648999006313 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 648999006314 substrate binding site [chemical binding]; other site 648999006315 16S rRNA methyltransferase B; Provisional; Region: PRK14902 648999006316 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 648999006317 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 648999006318 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 648999006319 Peptidase family M28; Region: Peptidase_M28; pfam04389 648999006320 active site 648999006321 metal binding site [ion binding]; metal-binding site 648999006322 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 648999006323 Septum formation; Region: Septum_form; pfam13845 648999006324 Septum formation; Region: Septum_form; pfam13845 648999006325 Septum formation; Region: Septum_form; pfam13845 648999006326 Septum formation; Region: Septum_form; pfam13845 648999006327 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 648999006328 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 648999006329 substrate binding site [chemical binding]; other site 648999006330 hexamer interface [polypeptide binding]; other site 648999006331 metal binding site [ion binding]; metal-binding site 648999006332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999006333 active site 648999006334 phosphorylation site [posttranslational modification] 648999006335 intermolecular recognition site; other site 648999006336 dimerization interface [polypeptide binding]; other site 648999006337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999006338 metal binding site [ion binding]; metal-binding site 648999006339 active site 648999006340 I-site; other site 648999006341 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 648999006342 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 648999006343 catalytic motif [active] 648999006344 Zn binding site [ion binding]; other site 648999006345 RibD C-terminal domain; Region: RibD_C; cl17279 648999006346 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 648999006347 Lumazine binding domain; Region: Lum_binding; pfam00677 648999006348 Lumazine binding domain; Region: Lum_binding; pfam00677 648999006349 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 648999006350 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 648999006351 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 648999006352 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 648999006353 dimerization interface [polypeptide binding]; other site 648999006354 active site 648999006355 6,7-dimethyl-8-ribityllumazine synthase; Provisional; Region: ribH; PRK00061 648999006356 active site 648999006357 homopentamer interface [polypeptide binding]; other site 648999006358 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 648999006359 homodimer interface [polypeptide binding]; other site 648999006360 putative metal binding site [ion binding]; other site 648999006361 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 648999006362 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 648999006363 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 648999006364 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 648999006365 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 648999006366 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 648999006367 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 648999006368 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 648999006369 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 648999006370 23S rRNA binding site [nucleotide binding]; other site 648999006371 L21 binding site [polypeptide binding]; other site 648999006372 L13 binding site [polypeptide binding]; other site 648999006373 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 648999006374 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 648999006375 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 648999006376 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 648999006377 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 648999006378 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 648999006379 dimer interface [polypeptide binding]; other site 648999006380 motif 1; other site 648999006381 active site 648999006382 motif 2; other site 648999006383 motif 3; other site 648999006384 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 648999006385 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 648999006386 putative tRNA-binding site [nucleotide binding]; other site 648999006387 B3/4 domain; Region: B3_4; pfam03483 648999006388 tRNA synthetase B5 domain; Region: B5; smart00874 648999006389 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 648999006390 dimer interface [polypeptide binding]; other site 648999006391 motif 1; other site 648999006392 motif 3; other site 648999006393 motif 2; other site 648999006394 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 648999006395 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 648999006396 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 648999006397 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 648999006398 heterotetramer interface [polypeptide binding]; other site 648999006399 active site pocket [active] 648999006400 cleavage site 648999006401 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 648999006402 feedback inhibition sensing region; other site 648999006403 homohexameric interface [polypeptide binding]; other site 648999006404 nucleotide binding site [chemical binding]; other site 648999006405 N-acetyl-L-glutamate binding site [chemical binding]; other site 648999006406 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 648999006407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999006408 inhibitor-cofactor binding pocket; inhibition site 648999006409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999006410 catalytic residue [active] 648999006411 ornithine carbamoyltransferase; Provisional; Region: PRK00779 648999006412 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 648999006413 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 648999006414 arginine repressor; Provisional; Region: PRK03341 648999006415 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 648999006416 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 648999006417 argininosuccinate synthase; Provisional; Region: PRK13820 648999006418 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 648999006419 ANP binding site [chemical binding]; other site 648999006420 Substrate Binding Site II [chemical binding]; other site 648999006421 Substrate Binding Site I [chemical binding]; other site 648999006422 argininosuccinate lyase; Provisional; Region: PRK00855 648999006423 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 648999006424 active sites [active] 648999006425 tetramer interface [polypeptide binding]; other site 648999006426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 648999006427 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 648999006428 active site 648999006429 DNA binding site [nucleotide binding] 648999006430 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 648999006431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999006432 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999006433 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 648999006434 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999006435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999006436 Ligand Binding Site [chemical binding]; other site 648999006437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999006438 Ligand Binding Site [chemical binding]; other site 648999006439 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 648999006440 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 648999006441 ligand binding site [chemical binding]; other site 648999006442 flexible hinge region; other site 648999006443 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 648999006444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999006445 FeS/SAM binding site; other site 648999006446 Pyruvate formate lyase 1; Region: PFL1; cd01678 648999006447 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 648999006448 coenzyme A binding site [chemical binding]; other site 648999006449 active site 648999006450 catalytic residues [active] 648999006451 glycine loop; other site 648999006452 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 648999006453 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 648999006454 NAD binding site [chemical binding]; other site 648999006455 substrate binding site [chemical binding]; other site 648999006456 catalytic Zn binding site [ion binding]; other site 648999006457 tetramer interface [polypeptide binding]; other site 648999006458 structural Zn binding site [ion binding]; other site 648999006459 pyruvate phosphate dikinase; Provisional; Region: PRK09279 648999006460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 648999006461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 648999006462 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 648999006463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999006464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999006465 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999006466 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999006467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999006468 Transporter associated domain; Region: CorC_HlyC; smart01091 648999006469 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 648999006470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 648999006471 CoenzymeA binding site [chemical binding]; other site 648999006472 subunit interaction site [polypeptide binding]; other site 648999006473 PHB binding site; other site 648999006474 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 648999006475 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 648999006476 active site 648999006477 HIGH motif; other site 648999006478 dimer interface [polypeptide binding]; other site 648999006479 KMSKS motif; other site 648999006480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 648999006481 RNA binding surface [nucleotide binding]; other site 648999006482 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 648999006483 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 648999006484 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 648999006485 VanW like protein; Region: VanW; pfam04294 648999006486 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 648999006487 putative NADH binding site [chemical binding]; other site 648999006488 putative active site [active] 648999006489 nudix motif; other site 648999006490 putative metal binding site [ion binding]; other site 648999006491 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 648999006492 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999006493 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999006494 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999006495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999006496 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 648999006497 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 648999006498 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 648999006499 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 648999006500 EamA-like transporter family; Region: EamA; pfam00892 648999006501 hypothetical protein; Provisional; Region: PRK07945 648999006502 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 648999006503 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 648999006504 active site 648999006505 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999006506 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999006507 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 648999006508 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 648999006509 nucleoside/Zn binding site; other site 648999006510 dimer interface [polypeptide binding]; other site 648999006511 catalytic motif [active] 648999006512 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 648999006513 active site 648999006514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999006515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999006516 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 648999006517 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 648999006518 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 648999006519 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 648999006520 nudix motif; other site 648999006521 YCII-related domain; Region: YCII; cl00999 648999006522 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 648999006523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 648999006524 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 648999006525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006526 Walker A motif; other site 648999006527 ATP binding site [chemical binding]; other site 648999006528 Walker B motif; other site 648999006529 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 648999006530 hypothetical protein; Validated; Region: PRK00153 648999006531 recombination protein RecR; Reviewed; Region: recR; PRK00076 648999006532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 648999006533 RecR protein; Region: RecR; pfam02132 648999006534 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 648999006535 putative active site [active] 648999006536 putative metal-binding site [ion binding]; other site 648999006537 tetramer interface [polypeptide binding]; other site 648999006538 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 648999006539 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999006540 peptide binding site [polypeptide binding]; other site 648999006541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999006542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999006543 dimer interface [polypeptide binding]; other site 648999006544 conserved gate region; other site 648999006545 putative PBP binding loops; other site 648999006546 ABC-ATPase subunit interface; other site 648999006547 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999006548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999006549 dimer interface [polypeptide binding]; other site 648999006550 conserved gate region; other site 648999006551 putative PBP binding loops; other site 648999006552 ABC-ATPase subunit interface; other site 648999006553 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999006554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999006555 Walker A/P-loop; other site 648999006556 ATP binding site [chemical binding]; other site 648999006557 Q-loop/lid; other site 648999006558 ABC transporter signature motif; other site 648999006559 Walker B; other site 648999006560 D-loop; other site 648999006561 H-loop/switch region; other site 648999006562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999006563 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 648999006564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999006565 Walker A/P-loop; other site 648999006566 ATP binding site [chemical binding]; other site 648999006567 Q-loop/lid; other site 648999006568 ABC transporter signature motif; other site 648999006569 Walker B; other site 648999006570 D-loop; other site 648999006571 H-loop/switch region; other site 648999006572 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999006573 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 648999006574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006575 putative substrate translocation pore; other site 648999006576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006577 2-isopropylmalate synthase; Validated; Region: PRK03739 648999006578 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 648999006579 active site 648999006580 catalytic residues [active] 648999006581 metal binding site [ion binding]; metal-binding site 648999006582 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 648999006583 aspartate kinase; Reviewed; Region: PRK06635 648999006584 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 648999006585 putative nucleotide binding site [chemical binding]; other site 648999006586 putative catalytic residues [active] 648999006587 putative Mg ion binding site [ion binding]; other site 648999006588 putative aspartate binding site [chemical binding]; other site 648999006589 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 648999006590 putative allosteric regulatory site; other site 648999006591 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 648999006592 putative allosteric regulatory residue; other site 648999006593 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 648999006594 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 648999006595 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 648999006596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999006597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999006598 metal binding site [ion binding]; metal-binding site 648999006599 active site 648999006600 I-site; other site 648999006601 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 648999006602 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 648999006603 active site 648999006604 metal binding site [ion binding]; metal-binding site 648999006605 hexamer interface [polypeptide binding]; other site 648999006606 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 648999006607 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 648999006608 putative active site [active] 648999006609 putative metal binding site [ion binding]; other site 648999006610 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 648999006611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999006612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999006613 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 648999006614 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 648999006615 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 648999006616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999006617 motif II; other site 648999006618 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 648999006619 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 648999006620 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999006621 putative active site [active] 648999006622 putative metal binding site [ion binding]; other site 648999006623 Yqey-like protein; Region: YqeY; cl17540 648999006624 Transglycosylase; Region: Transgly; pfam00912 648999006625 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 648999006626 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999006627 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999006628 Transcription factor WhiB; Region: Whib; pfam02467 648999006629 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 648999006630 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 648999006631 DTAP/Switch II; other site 648999006632 Switch I; other site 648999006633 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999006634 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 648999006635 DTAP/Switch II; other site 648999006636 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 648999006637 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 648999006638 homotrimer interaction site [polypeptide binding]; other site 648999006639 putative active site [active] 648999006640 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999006641 Double zinc ribbon; Region: DZR; pfam12773 648999006642 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 648999006643 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 648999006644 cyclase homology domain; Region: CHD; cd07302 648999006645 nucleotidyl binding site; other site 648999006646 metal binding site [ion binding]; metal-binding site 648999006647 dimer interface [polypeptide binding]; other site 648999006648 AAA ATPase domain; Region: AAA_16; pfam13191 648999006649 Protein kinase domain; Region: Pkinase; pfam00069 648999006650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999006651 active site 648999006652 ATP binding site [chemical binding]; other site 648999006653 substrate binding site [chemical binding]; other site 648999006654 activation loop (A-loop); other site 648999006655 TAP-like protein; Region: Abhydrolase_4; pfam08386 648999006656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999006657 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 648999006658 active site 648999006659 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 648999006660 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999006661 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999006662 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 648999006663 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 648999006664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 648999006665 carboxyltransferase (CT) interaction site; other site 648999006666 biotinylation site [posttranslational modification]; other site 648999006667 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 648999006668 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 648999006669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999006670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999006671 active site 648999006672 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 648999006673 TIGR03084 family protein; Region: TIGR03084 648999006674 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 648999006675 Wyosine base formation; Region: Wyosine_form; pfam08608 648999006676 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 648999006677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999006678 active site 648999006679 metal binding site [ion binding]; metal-binding site 648999006680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 648999006681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 648999006682 ligand binding site [chemical binding]; other site 648999006683 flexible hinge region; other site 648999006684 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 648999006685 non-specific DNA interactions [nucleotide binding]; other site 648999006686 DNA binding site [nucleotide binding] 648999006687 sequence specific DNA binding site [nucleotide binding]; other site 648999006688 putative cAMP binding site [chemical binding]; other site 648999006689 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 648999006690 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 648999006691 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 648999006692 putative active site [active] 648999006693 putative metal binding site [ion binding]; other site 648999006694 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 648999006695 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 648999006696 minor groove reading motif; other site 648999006697 helix-hairpin-helix signature motif; other site 648999006698 substrate binding pocket [chemical binding]; other site 648999006699 active site 648999006700 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 648999006701 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 648999006702 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999006703 catalytic residues [active] 648999006704 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 648999006705 putative active site [active] 648999006706 putative CoA binding site [chemical binding]; other site 648999006707 nudix motif; other site 648999006708 metal binding site [ion binding]; metal-binding site 648999006709 Colicin V production protein; Region: Colicin_V; pfam02674 648999006710 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 648999006711 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 648999006712 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 648999006713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 648999006714 active site 648999006715 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 648999006716 active site 648999006717 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 648999006718 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999006719 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 648999006720 active site 648999006721 catalytic residues [active] 648999006722 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 648999006723 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999006724 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 648999006725 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999006726 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999006727 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 648999006728 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 648999006729 dimer interface [polypeptide binding]; other site 648999006730 substrate binding site [chemical binding]; other site 648999006731 metal binding sites [ion binding]; metal-binding site 648999006732 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 648999006733 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 648999006734 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 648999006735 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 648999006736 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 648999006737 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 648999006738 TilS substrate binding domain; Region: TilS; pfam09179 648999006739 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 648999006740 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 648999006741 conserved cys residue [active] 648999006742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999006743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999006744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999006745 active site 648999006746 FtsH Extracellular; Region: FtsH_ext; pfam06480 648999006747 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 648999006748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006749 Walker A motif; other site 648999006750 ATP binding site [chemical binding]; other site 648999006751 Walker B motif; other site 648999006752 arginine finger; other site 648999006753 Peptidase family M41; Region: Peptidase_M41; pfam01434 648999006754 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 648999006755 homodecamer interface [polypeptide binding]; other site 648999006756 GTP cyclohydrolase I; Provisional; Region: PLN03044 648999006757 active site 648999006758 putative catalytic site residues [active] 648999006759 zinc binding site [ion binding]; other site 648999006760 GTP-CH-I/GFRP interaction surface; other site 648999006761 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999006762 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999006763 AAA-like domain; Region: AAA_10; pfam12846 648999006764 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 648999006765 dihydropteroate synthase; Region: DHPS; TIGR01496 648999006766 substrate binding pocket [chemical binding]; other site 648999006767 dimer interface [polypeptide binding]; other site 648999006768 inhibitor binding site; inhibition site 648999006769 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 648999006770 homooctamer interface [polypeptide binding]; other site 648999006771 active site 648999006772 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 648999006773 catalytic center binding site [active] 648999006774 ATP binding site [chemical binding]; other site 648999006775 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 648999006776 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 648999006777 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 648999006778 Walker A/P-loop; other site 648999006779 ATP binding site [chemical binding]; other site 648999006780 Q-loop/lid; other site 648999006781 ABC transporter signature motif; other site 648999006782 Walker B; other site 648999006783 D-loop; other site 648999006784 H-loop/switch region; other site 648999006785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999006786 ABC-ATPase subunit interface; other site 648999006787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999006788 ABC-ATPase subunit interface; other site 648999006789 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 648999006790 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 648999006791 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 648999006792 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 648999006793 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 648999006794 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 648999006795 pantoate--beta-alanine ligase; Region: panC; TIGR00018 648999006796 active site 648999006797 nucleotide binding site [chemical binding]; other site 648999006798 HIGH motif; other site 648999006799 KMSKS motif; other site 648999006800 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 648999006801 tetramerization interface [polypeptide binding]; other site 648999006802 active site 648999006803 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999006804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999006805 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999006806 Septum formation; Region: Septum_form; pfam13845 648999006807 Septum formation; Region: Septum_form; pfam13845 648999006808 L-aspartate oxidase; Provisional; Region: PRK07804 648999006809 L-aspartate oxidase; Provisional; Region: PRK06175 648999006810 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 648999006811 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 648999006812 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 648999006813 dimerization interface [polypeptide binding]; other site 648999006814 active site 648999006815 pantothenate kinase; Reviewed; Region: PRK13318 648999006816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999006817 S-adenosylmethionine binding site [chemical binding]; other site 648999006818 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 648999006819 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 648999006820 dimer interface [polypeptide binding]; other site 648999006821 putative anticodon binding site; other site 648999006822 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 648999006823 motif 1; other site 648999006824 dimer interface [polypeptide binding]; other site 648999006825 active site 648999006826 motif 2; other site 648999006827 motif 3; other site 648999006828 Lsr2; Region: Lsr2; pfam11774 648999006829 Clp protease ATP binding subunit; Region: clpC; CHL00095 648999006830 Clp amino terminal domain; Region: Clp_N; pfam02861 648999006831 Clp amino terminal domain; Region: Clp_N; pfam02861 648999006832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006833 Walker A motif; other site 648999006834 ATP binding site [chemical binding]; other site 648999006835 Walker B motif; other site 648999006836 arginine finger; other site 648999006837 UvrB/uvrC motif; Region: UVR; pfam02151 648999006838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999006839 Walker A motif; other site 648999006840 ATP binding site [chemical binding]; other site 648999006841 Walker B motif; other site 648999006842 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 648999006843 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 648999006844 endonuclease III; Region: ENDO3c; smart00478 648999006845 minor groove reading motif; other site 648999006846 helix-hairpin-helix signature motif; other site 648999006847 substrate binding pocket [chemical binding]; other site 648999006848 active site 648999006849 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 648999006850 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 648999006851 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 648999006852 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 648999006853 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 648999006854 active site 648999006855 catalytic residues [active] 648999006856 metal binding site [ion binding]; metal-binding site 648999006857 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 648999006858 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 648999006859 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 648999006860 DNA repair protein RadA; Provisional; Region: PRK11823 648999006861 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999006862 Walker A motif; other site 648999006863 ATP binding site [chemical binding]; other site 648999006864 Walker B motif; other site 648999006865 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 648999006866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999006867 S-adenosylmethionine binding site [chemical binding]; other site 648999006868 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 648999006869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999006870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999006871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999006872 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 648999006873 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 648999006874 malonyl-CoA binding site [chemical binding]; other site 648999006875 dimer interface [polypeptide binding]; other site 648999006876 active site 648999006877 product binding site; other site 648999006878 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 648999006879 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 648999006880 dimer interface; other site 648999006881 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 648999006882 homotrimer interaction site [polypeptide binding]; other site 648999006883 zinc binding site [ion binding]; other site 648999006884 CDP-binding sites; other site 648999006885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 648999006886 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999006887 CGNR zinc finger; Region: zf-CGNR; pfam11706 648999006888 TPR repeat; Region: TPR_11; pfam13414 648999006889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999006890 TPR motif; other site 648999006891 binding surface 648999006892 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 648999006893 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 648999006894 putative NAD(P) binding site [chemical binding]; other site 648999006895 putative substrate binding site [chemical binding]; other site 648999006896 catalytic Zn binding site [ion binding]; other site 648999006897 structural Zn binding site [ion binding]; other site 648999006898 dimer interface [polypeptide binding]; other site 648999006899 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 648999006900 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 648999006901 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 648999006902 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 648999006903 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999006904 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 648999006905 hydrophobic ligand binding site; other site 648999006906 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999006907 PQQ-like domain; Region: PQQ_2; pfam13360 648999006908 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 648999006909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999006910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999006911 homodimer interface [polypeptide binding]; other site 648999006912 catalytic residue [active] 648999006913 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 648999006914 RDD family; Region: RDD; pfam06271 648999006915 RDD family; Region: RDD; pfam06271 648999006916 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 648999006917 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 648999006918 dimer interface [polypeptide binding]; other site 648999006919 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 648999006920 active site 648999006921 Fe binding site [ion binding]; other site 648999006922 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 648999006923 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 648999006924 putative DNA binding site [nucleotide binding]; other site 648999006925 putative Zn2+ binding site [ion binding]; other site 648999006926 AsnC family; Region: AsnC_trans_reg; pfam01037 648999006927 PQQ-like domain; Region: PQQ_2; pfam13360 648999006928 fumarate hydratase; Provisional; Region: PRK15389 648999006929 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 648999006930 Fumarase C-terminus; Region: Fumerase_C; pfam05683 648999006931 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999006932 DNA binding site [nucleotide binding] 648999006933 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999006934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999006935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999006936 fumarate hydratase; Reviewed; Region: fumC; PRK00485 648999006937 Class II fumarases; Region: Fumarase_classII; cd01362 648999006938 active site 648999006939 tetramer interface [polypeptide binding]; other site 648999006940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999006941 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999006942 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 648999006943 CGNR zinc finger; Region: zf-CGNR; pfam11706 648999006944 EamA-like transporter family; Region: EamA; pfam00892 648999006945 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999006946 active site 648999006947 catalytic residues [active] 648999006948 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 648999006949 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 648999006950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999006951 active site 648999006952 HIGH motif; other site 648999006953 nucleotide binding site [chemical binding]; other site 648999006954 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 648999006955 KMSKS motif; other site 648999006956 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 648999006957 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 648999006958 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 648999006959 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 648999006960 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 648999006961 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 648999006962 Walker A/P-loop; other site 648999006963 ATP binding site [chemical binding]; other site 648999006964 Q-loop/lid; other site 648999006965 ABC transporter signature motif; other site 648999006966 Walker B; other site 648999006967 D-loop; other site 648999006968 H-loop/switch region; other site 648999006969 TOBE domain; Region: TOBE_2; pfam08402 648999006970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999006971 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999006972 active site 648999006973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999006974 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999006975 Coenzyme A binding pocket [chemical binding]; other site 648999006976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999006977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999006978 Helix-turn-helix domain; Region: HTH_18; pfam12833 648999006979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999006980 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 648999006981 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 648999006982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999006983 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999006984 catalytic core [active] 648999006985 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 648999006986 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 648999006987 potential catalytic triad [active] 648999006988 conserved cys residue [active] 648999006989 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 648999006990 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 648999006991 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 648999006992 active site 648999006993 Zn binding site [ion binding]; other site 648999006994 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 648999006995 enoyl-CoA hydratase; Provisional; Region: PRK06127 648999006996 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999006997 substrate binding site [chemical binding]; other site 648999006998 oxyanion hole (OAH) forming residues; other site 648999006999 trimer interface [polypeptide binding]; other site 648999007000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 648999007001 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 648999007002 putative catalytic residues [active] 648999007003 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999007004 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 648999007005 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 648999007006 active site 648999007007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999007008 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 648999007009 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 648999007010 TrkA-N domain; Region: TrkA_N; pfam02254 648999007011 TrkA-C domain; Region: TrkA_C; pfam02080 648999007012 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 648999007013 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 648999007014 active site 648999007015 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 648999007016 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 648999007017 active site 648999007018 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 648999007019 Chitinase C; Region: ChiC; pfam06483 648999007020 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 648999007021 aromatic chitin/cellulose binding site residues [chemical binding]; other site 648999007022 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 648999007023 aromatic chitin/cellulose binding site residues [chemical binding]; other site 648999007024 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 648999007025 active site 648999007026 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 648999007027 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 648999007028 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 648999007029 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 648999007030 active site 648999007031 dimer interface [polypeptide binding]; other site 648999007032 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999007033 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999007034 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 648999007035 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 648999007036 dimer interface [polypeptide binding]; other site 648999007037 active site 648999007038 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 648999007039 dimer interface [polypeptide binding]; other site 648999007040 active site 648999007041 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 648999007042 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 648999007043 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 648999007044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999007045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999007046 Walker A/P-loop; other site 648999007047 ATP binding site [chemical binding]; other site 648999007048 Q-loop/lid; other site 648999007049 ABC transporter signature motif; other site 648999007050 Walker B; other site 648999007051 D-loop; other site 648999007052 H-loop/switch region; other site 648999007053 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 648999007054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999007055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999007056 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 648999007057 putative hydrophobic ligand binding site [chemical binding]; other site 648999007058 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 648999007059 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 648999007060 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 648999007061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999007062 Walker A motif; other site 648999007063 ATP binding site [chemical binding]; other site 648999007064 Walker B motif; other site 648999007065 arginine finger; other site 648999007066 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 648999007067 Switch I region; other site 648999007068 G3 box; other site 648999007069 Switch II region; other site 648999007070 Protein of unknown function (DUF742); Region: DUF742; pfam05331 648999007071 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 648999007072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999007073 HAMP domain; Region: HAMP; pfam00672 648999007074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007075 ATP binding site [chemical binding]; other site 648999007076 Mg2+ binding site [ion binding]; other site 648999007077 G-X-G motif; other site 648999007078 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 648999007079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999007080 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 648999007081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999007082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999007083 Walker A/P-loop; other site 648999007084 ATP binding site [chemical binding]; other site 648999007085 Q-loop/lid; other site 648999007086 ABC transporter signature motif; other site 648999007087 Walker B; other site 648999007088 D-loop; other site 648999007089 H-loop/switch region; other site 648999007090 Predicted membrane protein [Function unknown]; Region: COG2259 648999007091 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 648999007092 threonine synthase; Validated; Region: PRK07591 648999007093 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 648999007094 homodimer interface [polypeptide binding]; other site 648999007095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999007096 catalytic residue [active] 648999007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007098 Coenzyme A binding pocket [chemical binding]; other site 648999007099 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 648999007100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999007101 NAD(P) binding site [chemical binding]; other site 648999007102 catalytic residues [active] 648999007103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007104 Coenzyme A binding pocket [chemical binding]; other site 648999007105 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999007106 DNA-binding site [nucleotide binding]; DNA binding site 648999007107 RNA-binding motif; other site 648999007108 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 648999007109 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 648999007110 ring oligomerisation interface [polypeptide binding]; other site 648999007111 ATP/Mg binding site [chemical binding]; other site 648999007112 stacking interactions; other site 648999007113 hinge regions; other site 648999007114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007115 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 648999007116 Coenzyme A binding pocket [chemical binding]; other site 648999007117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999007118 Coenzyme A binding pocket [chemical binding]; other site 648999007119 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999007120 active site 648999007121 catalytic residues [active] 648999007122 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 648999007123 FAD binding domain; Region: FAD_binding_4; pfam01565 648999007124 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 648999007125 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 648999007126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 648999007127 Predicted membrane protein [Function unknown]; Region: COG4129 648999007128 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999007129 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999007130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999007131 catalytic residue [active] 648999007132 Protease prsW family; Region: PrsW-protease; pfam13367 648999007133 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 648999007134 oligomerisation interface [polypeptide binding]; other site 648999007135 mobile loop; other site 648999007136 roof hairpin; other site 648999007137 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 648999007138 Domain of unknown function DUF20; Region: UPF0118; pfam01594 648999007139 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 648999007140 DEAD/DEAH box helicase; Region: DEAD; pfam00270 648999007141 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 648999007142 Protein of unknown function (DUF402); Region: DUF402; cl00979 648999007143 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 648999007144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999007145 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999007146 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999007147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999007148 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999007149 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 648999007150 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 648999007151 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 648999007152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999007153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999007154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999007155 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999007156 DinB superfamily; Region: DinB_2; pfam12867 648999007157 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 648999007158 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 648999007159 Walker A/P-loop; other site 648999007160 ATP binding site [chemical binding]; other site 648999007161 Q-loop/lid; other site 648999007162 ABC transporter signature motif; other site 648999007163 Walker B; other site 648999007164 D-loop; other site 648999007165 H-loop/switch region; other site 648999007166 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 648999007167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007168 dimer interface [polypeptide binding]; other site 648999007169 conserved gate region; other site 648999007170 putative PBP binding loops; other site 648999007171 ABC-ATPase subunit interface; other site 648999007172 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 648999007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007174 dimer interface [polypeptide binding]; other site 648999007175 conserved gate region; other site 648999007176 putative PBP binding loops; other site 648999007177 ABC-ATPase subunit interface; other site 648999007178 PBP superfamily domain; Region: PBP_like_2; cl17296 648999007179 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 648999007180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007181 Coenzyme A binding pocket [chemical binding]; other site 648999007182 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 648999007183 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999007184 NodB motif; other site 648999007185 active site 648999007186 catalytic site [active] 648999007187 metal binding site [ion binding]; metal-binding site 648999007188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999007189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999007190 DNA binding site [nucleotide binding] 648999007191 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 648999007192 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 648999007193 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 648999007194 active site residue [active] 648999007195 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 648999007196 active site residue [active] 648999007197 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 648999007198 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 648999007199 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 648999007200 SCP-2 sterol transfer family; Region: SCP2; pfam02036 648999007201 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 648999007202 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 648999007203 heme-binding site [chemical binding]; other site 648999007204 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 648999007205 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 648999007206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999007207 catalytic residue [active] 648999007208 ferric uptake regulator; Provisional; Region: fur; PRK09462 648999007209 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 648999007210 metal binding site 2 [ion binding]; metal-binding site 648999007211 putative DNA binding helix; other site 648999007212 metal binding site 1 [ion binding]; metal-binding site 648999007213 dimer interface [polypeptide binding]; other site 648999007214 structural Zn2+ binding site [ion binding]; other site 648999007215 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 648999007216 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 648999007217 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 648999007218 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 648999007219 L-asparaginase II; Region: Asparaginase_II; pfam06089 648999007220 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 648999007221 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 648999007222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999007223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999007224 non-specific DNA binding site [nucleotide binding]; other site 648999007225 salt bridge; other site 648999007226 sequence-specific DNA binding site [nucleotide binding]; other site 648999007227 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 648999007228 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 648999007229 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 648999007230 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 648999007231 CGNR zinc finger; Region: zf-CGNR; pfam11706 648999007232 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 648999007233 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 648999007234 short chain dehydrogenase; Provisional; Region: PRK08303 648999007235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999007236 NAD(P) binding site [chemical binding]; other site 648999007237 active site 648999007238 Predicted transcriptional regulator [Transcription]; Region: COG2378 648999007239 HTH domain; Region: HTH_11; pfam08279 648999007240 WYL domain; Region: WYL; pfam13280 648999007241 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 648999007242 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 648999007243 putative ADP-ribose binding site [chemical binding]; other site 648999007244 putative active site [active] 648999007245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999007246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007247 Coenzyme A binding pocket [chemical binding]; other site 648999007248 putative acetyltransferase; Provisional; Region: PRK03624 648999007249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999007250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999007251 DNA binding site [nucleotide binding] 648999007252 domain linker motif; other site 648999007253 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 648999007254 putative dimerization interface [polypeptide binding]; other site 648999007255 putative ligand binding site [chemical binding]; other site 648999007256 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999007257 beta-galactosidase; Region: BGL; TIGR03356 648999007258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007260 dimer interface [polypeptide binding]; other site 648999007261 conserved gate region; other site 648999007262 putative PBP binding loops; other site 648999007263 ABC-ATPase subunit interface; other site 648999007264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007265 dimer interface [polypeptide binding]; other site 648999007266 conserved gate region; other site 648999007267 ABC-ATPase subunit interface; other site 648999007268 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999007269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999007270 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 648999007271 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 648999007272 SCP-2 sterol transfer family; Region: SCP2; cl01225 648999007273 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 648999007274 FAD binding domain; Region: FAD_binding_4; pfam01565 648999007275 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 648999007276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999007277 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 648999007278 NAD(P) binding site [chemical binding]; other site 648999007279 active site 648999007280 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 648999007281 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 648999007282 putative ADP-binding pocket [chemical binding]; other site 648999007283 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 648999007284 transcription termination factor Rho; Provisional; Region: PRK12678 648999007285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999007286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999007289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999007291 catalytic core [active] 648999007292 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 648999007293 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 648999007294 PhoU domain; Region: PhoU; pfam01895 648999007295 PhoU domain; Region: PhoU; pfam01895 648999007296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999007297 dimer interface [polypeptide binding]; other site 648999007298 phosphorylation site [posttranslational modification] 648999007299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007300 ATP binding site [chemical binding]; other site 648999007301 Mg2+ binding site [ion binding]; other site 648999007302 G-X-G motif; other site 648999007303 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999007304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999007305 active site 648999007306 phosphorylation site [posttranslational modification] 648999007307 intermolecular recognition site; other site 648999007308 dimerization interface [polypeptide binding]; other site 648999007309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999007310 DNA binding site [nucleotide binding] 648999007311 exopolyphosphatase; Region: exo_poly_only; TIGR03706 648999007312 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 648999007313 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999007314 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 648999007315 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 648999007316 CGNR zinc finger; Region: zf-CGNR; pfam11706 648999007317 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 648999007318 Proline dehydrogenase; Region: Pro_dh; cl03282 648999007319 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999007320 active site 648999007321 metal binding site [ion binding]; metal-binding site 648999007322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999007323 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 648999007324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999007325 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 648999007326 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 648999007327 HlyD family secretion protein; Region: HlyD_3; pfam13437 648999007328 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 648999007329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999007330 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999007331 Walker A/P-loop; other site 648999007332 ATP binding site [chemical binding]; other site 648999007333 Q-loop/lid; other site 648999007334 ABC transporter signature motif; other site 648999007335 Walker B; other site 648999007336 D-loop; other site 648999007337 H-loop/switch region; other site 648999007338 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999007339 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 648999007340 FtsX-like permease family; Region: FtsX; pfam02687 648999007341 DNA binding domain, excisionase family; Region: excise; TIGR01764 648999007342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999007343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999007344 NAD(P) binding site [chemical binding]; other site 648999007345 active site 648999007346 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999007347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 648999007348 putative acyl-acceptor binding pocket; other site 648999007349 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 648999007350 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 648999007351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 648999007352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999007353 acyl-activating enzyme (AAE) consensus motif; other site 648999007354 AMP binding site [chemical binding]; other site 648999007355 active site 648999007356 CoA binding site [chemical binding]; other site 648999007357 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 648999007358 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 648999007359 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 648999007360 active site 1 [active] 648999007361 active site 2 [active] 648999007362 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 648999007363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999007364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999007365 active site 648999007366 phosphorylation site [posttranslational modification] 648999007367 intermolecular recognition site; other site 648999007368 dimerization interface [polypeptide binding]; other site 648999007369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999007370 DNA binding residues [nucleotide binding] 648999007371 dimerization interface [polypeptide binding]; other site 648999007372 Putative sensor; Region: Sensor; pfam13796 648999007373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999007374 Histidine kinase; Region: HisKA_3; pfam07730 648999007375 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 648999007376 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 648999007377 CoA binding domain; Region: CoA_binding; cl17356 648999007378 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 648999007379 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 648999007380 tRNA; other site 648999007381 putative tRNA binding site [nucleotide binding]; other site 648999007382 putative NADP binding site [chemical binding]; other site 648999007383 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 648999007384 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 648999007385 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 648999007386 domain interfaces; other site 648999007387 active site 648999007388 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 648999007389 active site 648999007390 homodimer interface [polypeptide binding]; other site 648999007391 SAM binding site [chemical binding]; other site 648999007392 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 648999007393 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 648999007394 active site 648999007395 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 648999007396 dimer interface [polypeptide binding]; other site 648999007397 active site 648999007398 Schiff base residues; other site 648999007399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999007400 non-specific DNA binding site [nucleotide binding]; other site 648999007401 salt bridge; other site 648999007402 sequence-specific DNA binding site [nucleotide binding]; other site 648999007403 Lamin Tail Domain; Region: LTD; pfam00932 648999007404 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 648999007405 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 648999007406 generic binding surface I; other site 648999007407 generic binding surface II; other site 648999007408 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999007409 putative catalytic site [active] 648999007410 putative phosphate binding site [ion binding]; other site 648999007411 putative metal binding site [ion binding]; other site 648999007412 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999007413 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 648999007414 N-acetyl-D-glucosamine binding site [chemical binding]; other site 648999007415 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 648999007416 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 648999007417 cyclase homology domain; Region: CHD; cd07302 648999007418 nucleotidyl binding site; other site 648999007419 metal binding site [ion binding]; metal-binding site 648999007420 dimer interface [polypeptide binding]; other site 648999007421 Predicted ATPase [General function prediction only]; Region: COG3903 648999007422 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 648999007423 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 648999007424 amino acid transporter; Region: 2A0306; TIGR00909 648999007425 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 648999007426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999007427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007428 dimer interface [polypeptide binding]; other site 648999007429 conserved gate region; other site 648999007430 putative PBP binding loops; other site 648999007431 ABC-ATPase subunit interface; other site 648999007432 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 648999007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007434 dimer interface [polypeptide binding]; other site 648999007435 conserved gate region; other site 648999007436 putative PBP binding loops; other site 648999007437 ABC-ATPase subunit interface; other site 648999007438 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999007439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 648999007440 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 648999007441 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 648999007442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999007443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999007444 DNA binding site [nucleotide binding] 648999007445 domain linker motif; other site 648999007446 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999007447 dimerization interface [polypeptide binding]; other site 648999007448 ligand binding site [chemical binding]; other site 648999007449 BON domain; Region: BON; pfam04972 648999007450 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999007451 Methyltransferase domain; Region: Methyltransf_11; pfam08241 648999007452 S-adenosylmethionine binding site [chemical binding]; other site 648999007453 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 648999007454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999007455 Walker A/P-loop; other site 648999007456 ATP binding site [chemical binding]; other site 648999007457 Q-loop/lid; other site 648999007458 ABC transporter signature motif; other site 648999007459 Walker B; other site 648999007460 D-loop; other site 648999007461 H-loop/switch region; other site 648999007462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999007463 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999007464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999007465 nucleotide binding site [chemical binding]; other site 648999007466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999007467 binding surface 648999007468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 648999007469 TPR motif; other site 648999007470 Tetratricopeptide repeat; Region: TPR_16; pfam13432 648999007471 Smr domain; Region: Smr; pfam01713 648999007472 AAA domain; Region: AAA_21; pfam13304 648999007473 YCII-related domain; Region: YCII; pfam03795 648999007474 YCII-related domain; Region: YCII; cl00999 648999007475 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999007476 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999007477 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 648999007478 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 648999007479 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 648999007480 Peptidase family M28; Region: Peptidase_M28; pfam04389 648999007481 metal binding site [ion binding]; metal-binding site 648999007482 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 648999007483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999007484 active site 648999007485 phosphorylation site [posttranslational modification] 648999007486 intermolecular recognition site; other site 648999007487 dimerization interface [polypeptide binding]; other site 648999007488 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999007489 CHASE3 domain; Region: CHASE3; pfam05227 648999007490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999007491 dimerization interface [polypeptide binding]; other site 648999007492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999007493 dimer interface [polypeptide binding]; other site 648999007494 phosphorylation site [posttranslational modification] 648999007495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007496 ATP binding site [chemical binding]; other site 648999007497 G-X-G motif; other site 648999007498 Response regulator receiver domain; Region: Response_reg; pfam00072 648999007499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999007500 active site 648999007501 phosphorylation site [posttranslational modification] 648999007502 intermolecular recognition site; other site 648999007503 dimerization interface [polypeptide binding]; other site 648999007504 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 648999007505 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999007506 active site 648999007507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999007509 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 648999007510 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999007511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999007512 active site 648999007513 ATP binding site [chemical binding]; other site 648999007514 substrate binding site [chemical binding]; other site 648999007515 activation loop (A-loop); other site 648999007516 Cellulose binding domain; Region: CBM_2; pfam00553 648999007517 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 648999007518 TrkA-N domain; Region: TrkA_N; pfam02254 648999007519 TrkA-C domain; Region: TrkA_C; pfam02080 648999007520 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 648999007521 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 648999007522 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 648999007523 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 648999007524 putative active site [active] 648999007525 catalytic site [active] 648999007526 putative metal binding site [ion binding]; other site 648999007527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999007528 DNA-binding site [nucleotide binding]; DNA binding site 648999007529 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999007530 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 648999007531 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999007532 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 648999007533 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 648999007534 Walker A/P-loop; other site 648999007535 ATP binding site [chemical binding]; other site 648999007536 Q-loop/lid; other site 648999007537 ABC transporter signature motif; other site 648999007538 Walker B; other site 648999007539 D-loop; other site 648999007540 H-loop/switch region; other site 648999007541 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 648999007542 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 648999007543 Walker A/P-loop; other site 648999007544 ATP binding site [chemical binding]; other site 648999007545 Q-loop/lid; other site 648999007546 ABC transporter signature motif; other site 648999007547 Walker B; other site 648999007548 D-loop; other site 648999007549 H-loop/switch region; other site 648999007550 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 648999007551 TM-ABC transporter signature motif; other site 648999007552 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 648999007553 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 648999007554 TM-ABC transporter signature motif; other site 648999007555 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999007556 DNA binding site [nucleotide binding] 648999007557 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999007558 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 648999007559 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999007560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999007561 ATP binding site [chemical binding]; other site 648999007562 putative Mg++ binding site [ion binding]; other site 648999007563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999007564 nucleotide binding region [chemical binding]; other site 648999007565 ATP-binding site [chemical binding]; other site 648999007566 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 648999007567 metal-binding site [ion binding] 648999007568 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999007569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999007570 non-specific DNA binding site [nucleotide binding]; other site 648999007571 salt bridge; other site 648999007572 sequence-specific DNA binding site [nucleotide binding]; other site 648999007573 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999007574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999007575 S-adenosylmethionine binding site [chemical binding]; other site 648999007576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 648999007577 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999007578 ATP binding site [chemical binding]; other site 648999007579 Mg++ binding site [ion binding]; other site 648999007580 motif III; other site 648999007581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999007582 nucleotide binding region [chemical binding]; other site 648999007583 ATP-binding site [chemical binding]; other site 648999007584 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 648999007585 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 648999007586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999007587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999007588 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 648999007589 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 648999007590 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 648999007591 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 648999007592 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 648999007593 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 648999007594 ATP binding site [chemical binding]; other site 648999007595 substrate interface [chemical binding]; other site 648999007596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999007597 active site residue [active] 648999007598 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 648999007599 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 648999007600 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 648999007601 putative catalytic cysteine [active] 648999007602 gamma-glutamyl kinase; Provisional; Region: PRK05429 648999007603 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 648999007604 nucleotide binding site [chemical binding]; other site 648999007605 homotetrameric interface [polypeptide binding]; other site 648999007606 putative phosphate binding site [ion binding]; other site 648999007607 putative allosteric binding site; other site 648999007608 PUA domain; Region: PUA; pfam01472 648999007609 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 648999007610 DNA binding site [nucleotide binding] 648999007611 active site 648999007612 MFS/sugar transport protein; Region: MFS_2; pfam13347 648999007613 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 648999007614 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 648999007615 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 648999007616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999007617 catalytic residue [active] 648999007618 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999007619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999007620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999007621 DNA binding residues [nucleotide binding] 648999007622 NADH dehydrogenase subunit B; Validated; Region: PRK06411 648999007623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 648999007624 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 648999007625 Glucose dehydrogenase; Region: glucose_DH; cd08230 648999007626 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 648999007627 NADP binding site [chemical binding]; other site 648999007628 catalytic Zn binding site [ion binding]; other site 648999007629 structural Zn binding site [ion binding]; other site 648999007630 dimer interface [polypeptide binding]; other site 648999007631 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 648999007632 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 648999007633 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 648999007634 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999007635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999007636 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999007637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999007638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999007639 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999007640 Walker A/P-loop; other site 648999007641 ATP binding site [chemical binding]; other site 648999007642 Q-loop/lid; other site 648999007643 ABC transporter signature motif; other site 648999007644 Walker B; other site 648999007645 D-loop; other site 648999007646 H-loop/switch region; other site 648999007647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999007648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999007649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999007650 Walker A/P-loop; other site 648999007651 ATP binding site [chemical binding]; other site 648999007652 Q-loop/lid; other site 648999007653 ABC transporter signature motif; other site 648999007654 Walker B; other site 648999007655 D-loop; other site 648999007656 H-loop/switch region; other site 648999007657 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 648999007658 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 648999007659 DNA binding site [nucleotide binding] 648999007660 active site 648999007661 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 648999007662 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 648999007663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999007664 AlkA N-terminal domain; Region: AlkA_N; pfam06029 648999007665 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 648999007666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 648999007667 helix-hairpin-helix signature motif; other site 648999007668 substrate binding pocket [chemical binding]; other site 648999007669 active site 648999007670 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 648999007671 EamA-like transporter family; Region: EamA; pfam00892 648999007672 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999007673 MarR family; Region: MarR; pfam01047 648999007674 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 648999007675 active site pocket [active] 648999007676 oxyanion hole [active] 648999007677 catalytic triad [active] 648999007678 active site nucleophile [active] 648999007679 GTP-binding protein YchF; Reviewed; Region: PRK09601 648999007680 YchF GTPase; Region: YchF; cd01900 648999007681 G1 box; other site 648999007682 GTP/Mg2+ binding site [chemical binding]; other site 648999007683 Switch I region; other site 648999007684 G2 box; other site 648999007685 Switch II region; other site 648999007686 G3 box; other site 648999007687 G4 box; other site 648999007688 G5 box; other site 648999007689 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 648999007690 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 648999007691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999007692 NAD(P) binding site [chemical binding]; other site 648999007693 active site 648999007694 RibD C-terminal domain; Region: RibD_C; cl17279 648999007695 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 648999007696 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 648999007697 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999007698 Walker A/P-loop; other site 648999007699 ATP binding site [chemical binding]; other site 648999007700 Q-loop/lid; other site 648999007701 ABC transporter signature motif; other site 648999007702 Walker B; other site 648999007703 D-loop; other site 648999007704 H-loop/switch region; other site 648999007705 Predicted transcriptional regulators [Transcription]; Region: COG1725 648999007706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999007707 DNA-binding site [nucleotide binding]; DNA binding site 648999007708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 648999007709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999007710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999007711 Coenzyme A binding pocket [chemical binding]; other site 648999007712 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999007713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999007714 S-adenosylmethionine binding site [chemical binding]; other site 648999007715 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 648999007716 putative active site [active] 648999007717 Pleckstrin homology-like domain; Region: PH-like; cl17171 648999007718 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 648999007719 aromatic arch; other site 648999007720 DCoH dimer interaction site [polypeptide binding]; other site 648999007721 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 648999007722 DCoH tetramer interaction site [polypeptide binding]; other site 648999007723 substrate binding site [chemical binding]; other site 648999007724 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 648999007725 active site 648999007726 8-oxo-dGMP binding site [chemical binding]; other site 648999007727 nudix motif; other site 648999007728 metal binding site [ion binding]; metal-binding site 648999007729 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 648999007730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 648999007731 catalytic loop [active] 648999007732 iron binding site [ion binding]; other site 648999007733 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 648999007734 L-aspartate oxidase; Provisional; Region: PRK06175 648999007735 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 648999007736 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 648999007737 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 648999007738 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 648999007739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 648999007740 putative active site [active] 648999007741 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999007742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999007743 Walker A/P-loop; other site 648999007744 ATP binding site [chemical binding]; other site 648999007745 Q-loop/lid; other site 648999007746 ABC transporter signature motif; other site 648999007747 Walker B; other site 648999007748 D-loop; other site 648999007749 H-loop/switch region; other site 648999007750 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999007751 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 648999007752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999007753 Walker A/P-loop; other site 648999007754 ATP binding site [chemical binding]; other site 648999007755 Q-loop/lid; other site 648999007756 ABC transporter signature motif; other site 648999007757 Walker B; other site 648999007758 D-loop; other site 648999007759 H-loop/switch region; other site 648999007760 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999007761 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 648999007762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007763 dimer interface [polypeptide binding]; other site 648999007764 conserved gate region; other site 648999007765 putative PBP binding loops; other site 648999007766 ABC-ATPase subunit interface; other site 648999007767 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999007769 dimer interface [polypeptide binding]; other site 648999007770 conserved gate region; other site 648999007771 putative PBP binding loops; other site 648999007772 ABC-ATPase subunit interface; other site 648999007773 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 648999007774 peptide binding site [polypeptide binding]; other site 648999007775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999007776 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 648999007777 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999007778 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 648999007779 hypothetical protein; Provisional; Region: PRK05415 648999007780 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999007781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999007782 Ferredoxin [Energy production and conversion]; Region: COG1146 648999007783 4Fe-4S binding domain; Region: Fer4; pfam00037 648999007784 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 648999007785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999007786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999007787 homodimer interface [polypeptide binding]; other site 648999007788 catalytic residue [active] 648999007789 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 648999007790 prephenate dehydrogenase; Validated; Region: PRK08507 648999007791 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 648999007792 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 648999007793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999007794 active site 648999007795 maltose O-acetyltransferase; Provisional; Region: PRK10092 648999007796 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 648999007797 active site 648999007798 substrate binding site [chemical binding]; other site 648999007799 trimer interface [polypeptide binding]; other site 648999007800 CoA binding site [chemical binding]; other site 648999007801 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999007802 active site 648999007803 catalytic residues [active] 648999007804 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 648999007805 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 648999007806 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 648999007807 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 648999007808 putative trimer interface [polypeptide binding]; other site 648999007809 putative CoA binding site [chemical binding]; other site 648999007810 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 648999007811 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 648999007812 metal binding site [ion binding]; metal-binding site 648999007813 putative dimer interface [polypeptide binding]; other site 648999007814 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 648999007815 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 648999007816 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 648999007817 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 648999007818 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 648999007819 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 648999007820 Part of AAA domain; Region: AAA_19; pfam13245 648999007821 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 648999007822 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999007823 DNA-binding site [nucleotide binding]; DNA binding site 648999007824 RNA-binding motif; other site 648999007825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 648999007826 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999007827 ATP binding site [chemical binding]; other site 648999007828 putative Mg++ binding site [ion binding]; other site 648999007829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999007830 nucleotide binding region [chemical binding]; other site 648999007831 ATP-binding site [chemical binding]; other site 648999007832 Predicted transcriptional regulator [Transcription]; Region: COG1959 648999007833 Transcriptional regulator; Region: Rrf2; pfam02082 648999007834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 648999007835 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 648999007836 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 648999007837 Walker A/P-loop; other site 648999007838 ATP binding site [chemical binding]; other site 648999007839 Q-loop/lid; other site 648999007840 ABC transporter signature motif; other site 648999007841 Walker B; other site 648999007842 D-loop; other site 648999007843 H-loop/switch region; other site 648999007844 NMT1-like family; Region: NMT1_2; pfam13379 648999007845 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 648999007846 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 648999007847 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 648999007848 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 648999007849 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 648999007850 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 648999007851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 648999007852 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 648999007853 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 648999007854 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 648999007855 putative NADH binding site [chemical binding]; other site 648999007856 putative active site [active] 648999007857 nudix motif; other site 648999007858 putative metal binding site [ion binding]; other site 648999007859 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999007860 Helix-turn-helix domain; Region: HTH_31; pfam13560 648999007861 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999007862 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 648999007863 catalytic residues [active] 648999007864 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 648999007865 Part of AAA domain; Region: AAA_19; pfam13245 648999007866 Family description; Region: UvrD_C_2; pfam13538 648999007867 HRDC domain; Region: HRDC; pfam00570 648999007868 Transcription factor WhiB; Region: Whib; pfam02467 648999007869 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 648999007870 ABC1 family; Region: ABC1; pfam03109 648999007871 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 648999007872 active site 648999007873 ATP binding site [chemical binding]; other site 648999007874 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 648999007875 Protein of unknown function DUF45; Region: DUF45; pfam01863 648999007876 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 648999007877 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 648999007878 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 648999007879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 648999007880 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 648999007881 hypothetical protein; Validated; Region: PRK00068 648999007882 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 648999007883 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999007884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999007885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999007886 DNA binding residues [nucleotide binding] 648999007887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999007888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999007889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007890 putative substrate translocation pore; other site 648999007891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999007892 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999007893 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 648999007894 ATP binding site [chemical binding]; other site 648999007895 active site 648999007896 substrate binding site [chemical binding]; other site 648999007897 glycerol kinase; Provisional; Region: glpK; PRK00047 648999007898 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 648999007899 N- and C-terminal domain interface [polypeptide binding]; other site 648999007900 active site 648999007901 MgATP binding site [chemical binding]; other site 648999007902 catalytic site [active] 648999007903 metal binding site [ion binding]; metal-binding site 648999007904 putative homotetramer interface [polypeptide binding]; other site 648999007905 glycerol binding site [chemical binding]; other site 648999007906 homodimer interface [polypeptide binding]; other site 648999007907 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 648999007908 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 648999007909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999007910 active site 648999007911 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999007912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007913 ATP binding site [chemical binding]; other site 648999007914 Mg2+ binding site [ion binding]; other site 648999007915 G-X-G motif; other site 648999007916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007917 ATP binding site [chemical binding]; other site 648999007918 Mg2+ binding site [ion binding]; other site 648999007919 G-X-G motif; other site 648999007920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999007921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999007922 active site 648999007923 phosphorylation site [posttranslational modification] 648999007924 intermolecular recognition site; other site 648999007925 dimerization interface [polypeptide binding]; other site 648999007926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999007927 DNA binding residues [nucleotide binding] 648999007928 dimerization interface [polypeptide binding]; other site 648999007929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999007930 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999007931 short chain dehydrogenase; Provisional; Region: PRK09072 648999007932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999007933 NAD(P) binding site [chemical binding]; other site 648999007934 active site 648999007935 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 648999007936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999007937 putative ADP-binding pocket [chemical binding]; other site 648999007938 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999007939 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 648999007940 active site 648999007941 Predicted GTPases [General function prediction only]; Region: COG1162 648999007942 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 648999007943 GTPase/Zn-binding domain interface [polypeptide binding]; other site 648999007944 GTP/Mg2+ binding site [chemical binding]; other site 648999007945 G4 box; other site 648999007946 G5 box; other site 648999007947 G1 box; other site 648999007948 Switch I region; other site 648999007949 G2 box; other site 648999007950 G3 box; other site 648999007951 Switch II region; other site 648999007952 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 648999007953 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 648999007954 hinge; other site 648999007955 active site 648999007956 Uncharacterized conserved protein [Function unknown]; Region: COG2135 648999007957 Transcription factor WhiB; Region: Whib; pfam02467 648999007958 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 648999007959 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 648999007960 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999007961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999007962 DNA binding residues [nucleotide binding] 648999007963 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 648999007964 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 648999007965 carboxyltransferase (CT) interaction site; other site 648999007966 biotinylation site [posttranslational modification]; other site 648999007967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999007968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999007969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999007970 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 648999007971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007972 putative substrate translocation pore; other site 648999007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999007974 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 648999007975 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 648999007976 dimer interface [polypeptide binding]; other site 648999007977 active site 648999007978 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 648999007979 dimer interface [polypeptide binding]; other site 648999007980 active site 648999007981 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 648999007982 PAS fold; Region: PAS_4; pfam08448 648999007983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 648999007984 Histidine kinase; Region: HisKA_2; pfam07568 648999007985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999007986 ATP binding site [chemical binding]; other site 648999007987 Mg2+ binding site [ion binding]; other site 648999007988 G-X-G motif; other site 648999007989 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 648999007990 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 648999007991 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 648999007992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 648999007993 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 648999007994 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 648999007995 Active Sites [active] 648999007996 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 648999007997 putative active site [active] 648999007998 Transcription factor WhiB; Region: Whib; pfam02467 648999007999 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 648999008000 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 648999008001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 648999008002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 648999008003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999008004 Coenzyme A binding pocket [chemical binding]; other site 648999008005 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 648999008006 Predicted transcriptional regulator [Transcription]; Region: COG2932 648999008007 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 648999008008 Catalytic site [active] 648999008009 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 648999008010 Malic enzyme, N-terminal domain; Region: malic; pfam00390 648999008011 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 648999008012 NAD(P) binding pocket [chemical binding]; other site 648999008013 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999008014 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999008015 NAD(P) binding site [chemical binding]; other site 648999008016 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999008017 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 648999008018 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999008019 Serine hydrolase (FSH1); Region: FSH1; pfam03959 648999008020 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 648999008021 propionate/acetate kinase; Provisional; Region: PRK12379 648999008022 phosphate acetyltransferase; Reviewed; Region: PRK05632 648999008023 DRTGG domain; Region: DRTGG; pfam07085 648999008024 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 648999008025 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 648999008026 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999008027 NodB motif; other site 648999008028 putative active site [active] 648999008029 putative catalytic site [active] 648999008030 putative Zn binding site [ion binding]; other site 648999008031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999008032 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 648999008033 DXD motif; other site 648999008034 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 648999008035 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999008036 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 648999008037 TPP-binding site [chemical binding]; other site 648999008038 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 648999008039 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999008040 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 648999008041 Walker A/P-loop; other site 648999008042 ATP binding site [chemical binding]; other site 648999008043 Q-loop/lid; other site 648999008044 ABC transporter signature motif; other site 648999008045 Walker B; other site 648999008046 D-loop; other site 648999008047 H-loop/switch region; other site 648999008048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 648999008049 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999008050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999008051 putative acyl-acceptor binding pocket; other site 648999008052 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 648999008053 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 648999008054 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999008055 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999008056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999008057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999008058 active site 648999008059 phosphorylation site [posttranslational modification] 648999008060 intermolecular recognition site; other site 648999008061 dimerization interface [polypeptide binding]; other site 648999008062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999008063 DNA binding site [nucleotide binding] 648999008064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999008065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999008066 dimerization interface [polypeptide binding]; other site 648999008067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999008068 dimer interface [polypeptide binding]; other site 648999008069 phosphorylation site [posttranslational modification] 648999008070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999008071 ATP binding site [chemical binding]; other site 648999008072 Mg2+ binding site [ion binding]; other site 648999008073 G-X-G motif; other site 648999008074 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 648999008075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 648999008076 protein binding site [polypeptide binding]; other site 648999008077 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 648999008078 BON domain; Region: BON; pfam04972 648999008079 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 648999008080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999008081 putative ADP-binding pocket [chemical binding]; other site 648999008082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999008083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999008084 active site 648999008085 ATP binding site [chemical binding]; other site 648999008086 substrate binding site [chemical binding]; other site 648999008087 activation loop (A-loop); other site 648999008088 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 648999008089 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 648999008090 nucleophile elbow; other site 648999008091 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999008092 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 648999008093 putative acyl-acceptor binding pocket; other site 648999008094 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 648999008095 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 648999008096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008097 NAD(P) binding site [chemical binding]; other site 648999008098 active site 648999008099 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 648999008100 Fatty acid desaturase; Region: FA_desaturase; pfam00487 648999008101 putative di-iron ligands [ion binding]; other site 648999008102 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 648999008103 phosphopeptide binding site; other site 648999008104 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999008105 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 648999008106 inhibitor-cofactor binding pocket; inhibition site 648999008107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999008108 catalytic residue [active] 648999008109 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 648999008110 Amidinotransferase; Region: Amidinotransf; pfam02274 648999008111 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 648999008112 active site 648999008113 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999008114 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999008115 putative sugar binding sites [chemical binding]; other site 648999008116 Q-X-W motif; other site 648999008117 Cellulose binding domain; Region: CBM_2; pfam00553 648999008118 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 648999008119 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 648999008120 putative DNA binding site [nucleotide binding]; other site 648999008121 catalytic residue [active] 648999008122 putative H2TH interface [polypeptide binding]; other site 648999008123 putative catalytic residues [active] 648999008124 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 648999008125 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 648999008126 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 648999008127 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 648999008128 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999008129 Trp docking motif [polypeptide binding]; other site 648999008130 active site 648999008131 PQQ-like domain; Region: PQQ_2; pfam13360 648999008132 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 648999008133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999008134 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999008135 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 648999008136 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 648999008137 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 648999008138 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 648999008139 active site 648999008140 catalytic residues [active] 648999008141 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 648999008142 metal binding site [ion binding]; metal-binding site 648999008143 ligand binding site [chemical binding]; other site 648999008144 Cellulose binding domain; Region: CBM_2; pfam00553 648999008145 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999008146 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 648999008147 active site 648999008148 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999008149 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999008150 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 648999008151 trehalose synthase; Region: treS_nterm; TIGR02456 648999008152 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 648999008153 active site 648999008154 catalytic site [active] 648999008155 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 648999008156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008157 NAD(P) binding site [chemical binding]; other site 648999008158 active site 648999008159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999008160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999008161 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 648999008162 Erythromycin esterase; Region: Erythro_esteras; pfam05139 648999008163 MMPL family; Region: MMPL; pfam03176 648999008164 MMPL family; Region: MMPL; pfam03176 648999008165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999008166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999008167 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999008168 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999008169 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 648999008170 nucleotide binding site [chemical binding]; other site 648999008171 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 648999008172 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 648999008173 Cupin; Region: Cupin_1; smart00835 648999008174 Cupin; Region: Cupin_1; smart00835 648999008175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999008176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999008177 DNA binding residues [nucleotide binding] 648999008178 dimerization interface [polypeptide binding]; other site 648999008179 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 648999008180 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999008181 Walker A/P-loop; other site 648999008182 ATP binding site [chemical binding]; other site 648999008183 Q-loop/lid; other site 648999008184 ABC transporter signature motif; other site 648999008185 Walker B; other site 648999008186 D-loop; other site 648999008187 H-loop/switch region; other site 648999008188 Predicted transcriptional regulators [Transcription]; Region: COG1725 648999008189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999008190 DNA-binding site [nucleotide binding]; DNA binding site 648999008191 AAA domain; Region: AAA_21; pfam13304 648999008192 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 648999008193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 648999008194 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 648999008195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008196 NAD(P) binding site [chemical binding]; other site 648999008197 active site 648999008198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999008199 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999008200 non-specific DNA binding site [nucleotide binding]; other site 648999008201 salt bridge; other site 648999008202 sequence-specific DNA binding site [nucleotide binding]; other site 648999008203 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 648999008204 sequence-specific DNA binding site [nucleotide binding]; other site 648999008205 salt bridge; other site 648999008206 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999008207 nudix motif; other site 648999008208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999008209 sequence-specific DNA binding site [nucleotide binding]; other site 648999008210 salt bridge; other site 648999008211 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999008212 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 648999008213 polymerase nucleotide-binding site; other site 648999008214 DNA-binding residues [nucleotide binding]; DNA binding site 648999008215 nucleotide binding site [chemical binding]; other site 648999008216 primase nucleotide-binding site [nucleotide binding]; other site 648999008217 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 648999008218 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 648999008219 Transposase; Region: HTH_Tnp_1; pfam01527 648999008220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 648999008221 putative transposase OrfB; Reviewed; Region: PHA02517 648999008222 HTH-like domain; Region: HTH_21; pfam13276 648999008223 Integrase core domain; Region: rve; pfam00665 648999008224 Integrase core domain; Region: rve_3; pfam13683 648999008225 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999008226 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 648999008227 active site 648999008228 catalytic residues [active] 648999008229 DNA binding site [nucleotide binding] 648999008230 Int/Topo IB signature motif; other site 648999008231 Winged helix-turn helix; Region: HTH_33; pfam13592 648999008232 Domain of unknown function (DUF305); Region: DUF305; pfam03713 648999008233 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 648999008234 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 648999008235 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 648999008236 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 648999008237 active site 648999008238 HIGH motif; other site 648999008239 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999008240 KMSK motif region; other site 648999008241 tRNA binding surface [nucleotide binding]; other site 648999008242 DALR anticodon binding domain; Region: DALR_1; smart00836 648999008243 anticodon binding site; other site 648999008244 diaminopimelate decarboxylase; Region: lysA; TIGR01048 648999008245 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 648999008246 active site 648999008247 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999008248 substrate binding site [chemical binding]; other site 648999008249 catalytic residues [active] 648999008250 dimer interface [polypeptide binding]; other site 648999008251 homoserine dehydrogenase; Provisional; Region: PRK06349 648999008252 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 648999008253 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 648999008254 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 648999008255 threonine synthase; Reviewed; Region: PRK06721 648999008256 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 648999008257 homodimer interface [polypeptide binding]; other site 648999008258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999008259 catalytic residue [active] 648999008260 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 648999008261 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999008262 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 648999008263 NodB motif; other site 648999008264 active site 648999008265 metal binding site [ion binding]; metal-binding site 648999008266 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999008267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999008268 homoserine kinase; Provisional; Region: PRK01212 648999008269 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 648999008270 transcription termination factor Rho; Provisional; Region: PRK12608 648999008271 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 648999008272 RNA binding site [nucleotide binding]; other site 648999008273 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999008274 Walker A motif; other site 648999008275 ATP binding site [chemical binding]; other site 648999008276 Walker B motif; other site 648999008277 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 648999008278 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999008279 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 648999008280 active site 648999008281 metal binding site [ion binding]; metal-binding site 648999008282 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 648999008283 This domain is found in peptide chain release factors; Region: PCRF; smart00937 648999008284 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 648999008285 RF-1 domain; Region: RF-1; pfam00472 648999008286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999008287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999008288 metal binding site [ion binding]; metal-binding site 648999008289 active site 648999008290 I-site; other site 648999008291 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 648999008292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999008293 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 648999008294 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 648999008295 Low molecular weight phosphatase family; Region: LMWPc; cl00105 648999008296 active site 648999008297 Transglycosylase; Region: Transgly; pfam00912 648999008298 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 648999008299 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999008300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999008301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999008302 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 648999008303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999008304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008305 NAD(P) binding site [chemical binding]; other site 648999008306 active site 648999008307 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 648999008308 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 648999008309 putative NAD(P) binding site [chemical binding]; other site 648999008310 putative active site [active] 648999008311 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 648999008312 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 648999008313 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 648999008314 dimer interface [polypeptide binding]; other site 648999008315 active site 648999008316 glycine-pyridoxal phosphate binding site [chemical binding]; other site 648999008317 folate binding site [chemical binding]; other site 648999008318 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 648999008319 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 648999008320 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 648999008321 ATP synthase subunit C; Region: ATP-synt_C; cl00466 648999008322 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 648999008323 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 648999008324 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 648999008325 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 648999008326 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 648999008327 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 648999008328 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 648999008329 beta subunit interaction interface [polypeptide binding]; other site 648999008330 Walker A motif; other site 648999008331 ATP binding site [chemical binding]; other site 648999008332 Walker B motif; other site 648999008333 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 648999008334 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 648999008335 core domain interface [polypeptide binding]; other site 648999008336 delta subunit interface [polypeptide binding]; other site 648999008337 epsilon subunit interface [polypeptide binding]; other site 648999008338 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 648999008339 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 648999008340 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 648999008341 alpha subunit interaction interface [polypeptide binding]; other site 648999008342 Walker A motif; other site 648999008343 ATP binding site [chemical binding]; other site 648999008344 Walker B motif; other site 648999008345 inhibitor binding site; inhibition site 648999008346 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 648999008347 Transcriptional regulator [Transcription]; Region: LytR; COG1316 648999008348 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 648999008349 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 648999008350 gamma subunit interface [polypeptide binding]; other site 648999008351 epsilon subunit interface [polypeptide binding]; other site 648999008352 LBP interface [polypeptide binding]; other site 648999008353 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 648999008354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 648999008355 putative dimer interface [polypeptide binding]; other site 648999008356 ligand binding site [chemical binding]; other site 648999008357 Zn binding site [ion binding]; other site 648999008358 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 648999008359 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 648999008360 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 648999008361 hinge; other site 648999008362 active site 648999008363 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999008364 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 648999008365 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999008366 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999008367 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999008368 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999008369 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999008370 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999008371 Walker A/P-loop; other site 648999008372 ATP binding site [chemical binding]; other site 648999008373 Q-loop/lid; other site 648999008374 ABC transporter signature motif; other site 648999008375 Walker B; other site 648999008376 D-loop; other site 648999008377 H-loop/switch region; other site 648999008378 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999008379 Transcriptional regulator PadR-like family; Region: PadR; cl17335 648999008380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999008381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999008382 Walker A/P-loop; other site 648999008383 ATP binding site [chemical binding]; other site 648999008384 Q-loop/lid; other site 648999008385 ABC transporter signature motif; other site 648999008386 Walker B; other site 648999008387 D-loop; other site 648999008388 H-loop/switch region; other site 648999008389 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 648999008390 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 648999008391 B12 binding site [chemical binding]; other site 648999008392 cobalt ligand [ion binding]; other site 648999008393 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 648999008394 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 648999008395 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 648999008396 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 648999008397 hypothetical protein; Provisional; Region: PRK03298 648999008398 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999008399 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 648999008400 NAD(P) binding site [chemical binding]; other site 648999008401 catalytic residues [active] 648999008402 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 648999008403 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 648999008404 phosphopeptide binding site; other site 648999008405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999008406 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 648999008407 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999008408 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999008409 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 648999008410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999008411 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999008412 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999008413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999008414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999008415 DNA binding residues [nucleotide binding] 648999008416 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999008417 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 648999008418 major vault protein; Provisional; Region: PTZ00491 648999008419 DivIVA protein; Region: DivIVA; pfam05103 648999008420 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999008421 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 648999008422 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999008423 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 648999008424 NAD(P) binding site [chemical binding]; other site 648999008425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999008426 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 648999008427 dimer interface [polypeptide binding]; other site 648999008428 substrate binding site [chemical binding]; other site 648999008429 metal binding site [ion binding]; metal-binding site 648999008430 putative acyltransferase; Provisional; Region: PRK05790 648999008431 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999008432 dimer interface [polypeptide binding]; other site 648999008433 active site 648999008434 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 648999008435 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 648999008436 Walker A; other site 648999008437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999008438 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 648999008439 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999008440 Asp23 family; Region: Asp23; pfam03780 648999008441 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999008442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999008443 DNA-binding site [nucleotide binding]; DNA binding site 648999008444 FCD domain; Region: FCD; pfam07729 648999008445 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 648999008446 putative active site pocket [active] 648999008447 cleavage site 648999008448 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 648999008449 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999008450 Uncharacterized conserved protein [Function unknown]; Region: COG1262 648999008451 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 648999008452 tartrate dehydrogenase; Region: TTC; TIGR02089 648999008453 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 648999008454 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999008455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999008456 DNA-binding site [nucleotide binding]; DNA binding site 648999008457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999008458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999008459 homodimer interface [polypeptide binding]; other site 648999008460 catalytic residue [active] 648999008461 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 648999008462 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 648999008463 metal binding site [ion binding]; metal-binding site 648999008464 dimer interface [polypeptide binding]; other site 648999008465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999008466 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999008467 NAD(P) binding site [chemical binding]; other site 648999008468 catalytic residues [active] 648999008469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999008470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999008471 dimer interface [polypeptide binding]; other site 648999008472 conserved gate region; other site 648999008473 putative PBP binding loops; other site 648999008474 ABC-ATPase subunit interface; other site 648999008475 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 648999008476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999008477 putative PBP binding loops; other site 648999008478 ABC-ATPase subunit interface; other site 648999008479 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999008480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999008481 Walker A/P-loop; other site 648999008482 ATP binding site [chemical binding]; other site 648999008483 Q-loop/lid; other site 648999008484 ABC transporter signature motif; other site 648999008485 Walker B; other site 648999008486 D-loop; other site 648999008487 H-loop/switch region; other site 648999008488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999008489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 648999008490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999008491 Walker A/P-loop; other site 648999008492 ATP binding site [chemical binding]; other site 648999008493 Q-loop/lid; other site 648999008494 ABC transporter signature motif; other site 648999008495 Walker B; other site 648999008496 D-loop; other site 648999008497 H-loop/switch region; other site 648999008498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999008499 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 648999008500 classical (c) SDRs; Region: SDR_c; cd05233 648999008501 NAD(P) binding site [chemical binding]; other site 648999008502 active site 648999008503 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 648999008504 Sulfatase; Region: Sulfatase; pfam00884 648999008505 Sulfatase; Region: Sulfatase; cl17466 648999008506 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 648999008507 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 648999008508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999008509 E3 interaction surface; other site 648999008510 lipoyl attachment site [posttranslational modification]; other site 648999008511 e3 binding domain; Region: E3_binding; pfam02817 648999008512 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999008513 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999008514 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 648999008515 alpha subunit interface [polypeptide binding]; other site 648999008516 TPP binding site [chemical binding]; other site 648999008517 heterodimer interface [polypeptide binding]; other site 648999008518 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999008519 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 648999008520 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 648999008521 TPP-binding site [chemical binding]; other site 648999008522 tetramer interface [polypeptide binding]; other site 648999008523 heterodimer interface [polypeptide binding]; other site 648999008524 phosphorylation loop region [posttranslational modification] 648999008525 hypothetical protein; Provisional; Region: PRK06062 648999008526 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999008527 inhibitor-cofactor binding pocket; inhibition site 648999008528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999008529 catalytic residue [active] 648999008530 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 648999008531 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 648999008532 tetrameric interface [polypeptide binding]; other site 648999008533 NAD binding site [chemical binding]; other site 648999008534 catalytic residues [active] 648999008535 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 648999008536 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999008537 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 648999008538 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 648999008539 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999008540 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 648999008541 active site 648999008542 Mn binding site [ion binding]; other site 648999008543 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 648999008544 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 648999008545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 648999008546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 648999008547 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 648999008548 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 648999008549 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 648999008550 active site 648999008551 putative catalytic site [active] 648999008552 Cellulose binding domain; Region: CBM_2; pfam00553 648999008553 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 648999008554 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 648999008555 Na binding site [ion binding]; other site 648999008556 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999008557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999008558 ATP binding site [chemical binding]; other site 648999008559 Mg2+ binding site [ion binding]; other site 648999008560 G-X-G motif; other site 648999008561 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 648999008562 Protein of unknown function (DUF742); Region: DUF742; pfam05331 648999008563 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 648999008564 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 648999008565 G1 box; other site 648999008566 GTP/Mg2+ binding site [chemical binding]; other site 648999008567 G2 box; other site 648999008568 Switch I region; other site 648999008569 G3 box; other site 648999008570 Switch II region; other site 648999008571 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 648999008572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 648999008573 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 648999008574 metal ion-dependent adhesion site (MIDAS); other site 648999008575 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 648999008576 Bacterial sugar transferase; Region: Bac_transf; pfam02397 648999008577 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999008578 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999008579 MarR family; Region: MarR_2; pfam12802 648999008580 B12 binding domain; Region: B12-binding_2; pfam02607 648999008581 B12 binding domain; Region: B12-binding; pfam02310 648999008582 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 648999008583 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999008584 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999008585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999008586 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 648999008587 xylose isomerase; Provisional; Region: PRK12677 648999008588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999008589 D-xylulose kinase; Region: XylB; TIGR01312 648999008590 nucleotide binding site [chemical binding]; other site 648999008591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999008592 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 648999008593 active site 648999008594 catalytic site [active] 648999008595 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999008596 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999008597 DNA binding site [nucleotide binding] 648999008598 domain linker motif; other site 648999008599 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999008600 ligand binding site [chemical binding]; other site 648999008601 dimerization interface [polypeptide binding]; other site 648999008602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999008603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999008604 dimer interface [polypeptide binding]; other site 648999008605 conserved gate region; other site 648999008606 putative PBP binding loops; other site 648999008607 ABC-ATPase subunit interface; other site 648999008608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999008609 dimer interface [polypeptide binding]; other site 648999008610 conserved gate region; other site 648999008611 putative PBP binding loops; other site 648999008612 ABC-ATPase subunit interface; other site 648999008613 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999008614 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999008615 TspO/MBR family; Region: TspO_MBR; pfam03073 648999008616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999008617 active site 648999008618 metal binding site [ion binding]; metal-binding site 648999008619 Protein of unknown function DUF91; Region: DUF91; cl00709 648999008620 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 648999008621 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 648999008622 TMP-binding site; other site 648999008623 ATP-binding site [chemical binding]; other site 648999008624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008625 NAD(P) binding site [chemical binding]; other site 648999008626 active site 648999008627 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 648999008628 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 648999008629 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 648999008630 putative active site [active] 648999008631 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 648999008632 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 648999008633 putative active site [active] 648999008634 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 648999008635 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 648999008636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999008637 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999008638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999008639 DNA binding residues [nucleotide binding] 648999008640 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999008641 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999008642 integral membrane protein; Region: integ_memb_HG; TIGR03954 648999008643 Glucitol operon activator protein (GutM); Region: GutM; cl01890 648999008644 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999008645 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 648999008646 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 648999008647 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 648999008648 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 648999008649 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 648999008650 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 648999008651 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 648999008652 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 648999008653 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 648999008654 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 648999008655 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 648999008656 FOG: CBS domain [General function prediction only]; Region: COG0517 648999008657 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 648999008658 SCP-2 sterol transfer family; Region: SCP2; pfam02036 648999008659 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 648999008660 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 648999008661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999008662 active site 648999008663 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 648999008664 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999008665 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999008666 putative acyl-acceptor binding pocket; other site 648999008667 Response regulator receiver domain; Region: Response_reg; pfam00072 648999008668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 648999008669 active site 648999008670 phosphorylation site [posttranslational modification] 648999008671 intermolecular recognition site; other site 648999008672 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 648999008673 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 648999008674 DNA binding residues [nucleotide binding] 648999008675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999008676 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 648999008677 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 648999008678 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 648999008679 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999008680 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 648999008681 short chain dehydrogenase; Validated; Region: PRK08264 648999008682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999008683 NAD(P) binding site [chemical binding]; other site 648999008684 active site 648999008685 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 648999008686 Barstar (barnase inhibitor); Region: Barstar; pfam01337 648999008687 RNAase interaction site [polypeptide binding]; other site 648999008688 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999008689 nudix motif; other site 648999008690 AAA domain; Region: AAA_18; pfam13238 648999008691 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999008692 active site 648999008693 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 648999008694 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 648999008695 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 648999008696 30S subunit binding site; other site 648999008697 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 648999008698 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 648999008699 dimer interface [polypeptide binding]; other site 648999008700 ssDNA binding site [nucleotide binding]; other site 648999008701 tetramer (dimer of dimers) interface [polypeptide binding]; other site 648999008702 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 648999008703 cobyric acid synthase; Provisional; Region: PRK00784 648999008704 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 648999008705 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 648999008706 catalytic triad [active] 648999008707 Rhodanese Homology Domain; Region: RHOD; smart00450 648999008708 active site residue [active] 648999008709 hypothetical protein; Provisional; Region: PRK06547 648999008710 hypothetical protein; Provisional; Region: PRK07907 648999008711 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 648999008712 active site 648999008713 metal binding site [ion binding]; metal-binding site 648999008714 dimer interface [polypeptide binding]; other site 648999008715 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 648999008716 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 648999008717 active site 648999008718 DNA binding site [nucleotide binding] 648999008719 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 648999008720 DNA binding site [nucleotide binding] 648999008721 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 648999008722 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 648999008723 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 648999008724 conserved cys residue [active] 648999008725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999008726 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999008727 Transglycosylase; Region: Transgly; pfam00912 648999008728 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 648999008729 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999008730 hypothetical protein; Provisional; Region: PRK07908 648999008731 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999008732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999008733 homodimer interface [polypeptide binding]; other site 648999008734 catalytic residue [active] 648999008735 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 648999008736 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 648999008737 putative dimer interface [polypeptide binding]; other site 648999008738 active site pocket [active] 648999008739 putative cataytic base [active] 648999008740 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 648999008741 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 648999008742 active site 648999008743 SAM binding site [chemical binding]; other site 648999008744 homodimer interface [polypeptide binding]; other site 648999008745 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 648999008746 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 648999008747 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 648999008748 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 648999008749 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 648999008750 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 648999008751 active site 648999008752 homotetramer interface [polypeptide binding]; other site 648999008753 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 648999008754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999008755 Walker A/P-loop; other site 648999008756 ATP binding site [chemical binding]; other site 648999008757 Q-loop/lid; other site 648999008758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999008759 ABC transporter; Region: ABC_tran_2; pfam12848 648999008760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999008761 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 648999008762 active site 648999008763 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 648999008764 apolar tunnel; other site 648999008765 heme binding site [chemical binding]; other site 648999008766 dimerization interface [polypeptide binding]; other site 648999008767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999008768 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999008769 putative substrate translocation pore; other site 648999008770 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 648999008771 Mechanosensitive ion channel; Region: MS_channel; pfam00924 648999008772 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 648999008773 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 648999008774 active site 648999008775 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 648999008776 active site 648999008777 putative catalytic site [active] 648999008778 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 648999008779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999008780 dimerization interface [polypeptide binding]; other site 648999008781 putative Zn2+ binding site [ion binding]; other site 648999008782 putative DNA binding site [nucleotide binding]; other site 648999008783 AsnC family; Region: AsnC_trans_reg; pfam01037 648999008784 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 648999008785 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999008786 kynureninase; Region: kynureninase; TIGR01814 648999008787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999008788 catalytic residue [active] 648999008789 FAD binding domain; Region: FAD_binding_3; pfam01494 648999008790 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999008791 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999008792 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 648999008793 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 648999008794 NAD binding site [chemical binding]; other site 648999008795 catalytic residues [active] 648999008796 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 648999008797 acetaldehyde dehydrogenase; Validated; Region: PRK08300 648999008798 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 648999008799 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 648999008800 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 648999008801 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 648999008802 active site 648999008803 catalytic residues [active] 648999008804 metal binding site [ion binding]; metal-binding site 648999008805 DmpG-like communication domain; Region: DmpG_comm; pfam07836 648999008806 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 648999008807 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 648999008808 homotrimer interaction site [polypeptide binding]; other site 648999008809 putative active site [active] 648999008810 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 648999008811 Amidohydrolase; Region: Amidohydro_2; pfam04909 648999008812 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999008813 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 648999008814 Amidase; Region: Amidase; cl11426 648999008815 Repair protein; Region: Repair_PSII; pfam04536 648999008816 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 648999008817 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 648999008818 Zn binding site [ion binding]; other site 648999008819 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 648999008820 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 648999008821 catalytic residues [active] 648999008822 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 648999008823 Uncharacterized conserved protein [Function unknown]; Region: COG4198 648999008824 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 648999008825 hypothetical protein; Provisional; Region: PRK01346 648999008826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 648999008827 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 648999008828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999008829 acyl-activating enzyme (AAE) consensus motif; other site 648999008830 AMP binding site [chemical binding]; other site 648999008831 active site 648999008832 CoA binding site [chemical binding]; other site 648999008833 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 648999008834 active site 648999008835 Zn binding site [ion binding]; other site 648999008836 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 648999008837 nucleotide binding site [chemical binding]; other site 648999008838 putative NEF/HSP70 interaction site [polypeptide binding]; other site 648999008839 SBD interface [polypeptide binding]; other site 648999008840 PQQ-like domain; Region: PQQ_2; pfam13360 648999008841 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 648999008842 Trp docking motif [polypeptide binding]; other site 648999008843 active site 648999008844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 648999008845 MOSC domain; Region: MOSC; pfam03473 648999008846 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 648999008847 nucleoside/Zn binding site; other site 648999008848 dimer interface [polypeptide binding]; other site 648999008849 catalytic motif [active] 648999008850 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 648999008851 putative ADP-ribose binding site [chemical binding]; other site 648999008852 putative active site [active] 648999008853 trigger factor; Provisional; Region: tig; PRK01490 648999008854 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 648999008855 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 648999008856 Clp protease; Region: CLP_protease; pfam00574 648999008857 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 648999008858 oligomer interface [polypeptide binding]; other site 648999008859 active site residues [active] 648999008860 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 648999008861 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 648999008862 oligomer interface [polypeptide binding]; other site 648999008863 active site residues [active] 648999008864 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 648999008865 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 648999008866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999008867 Walker A motif; other site 648999008868 ATP binding site [chemical binding]; other site 648999008869 Walker B motif; other site 648999008870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 648999008871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999008872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999008873 non-specific DNA binding site [nucleotide binding]; other site 648999008874 salt bridge; other site 648999008875 sequence-specific DNA binding site [nucleotide binding]; other site 648999008876 Cupin domain; Region: Cupin_2; pfam07883 648999008877 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 648999008878 putative active site [active] 648999008879 catalytic triad [active] 648999008880 dimer interface [polypeptide binding]; other site 648999008881 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 648999008882 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 648999008883 HIGH motif; other site 648999008884 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 648999008885 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 648999008886 active site 648999008887 KMSKS motif; other site 648999008888 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 648999008889 tRNA binding surface [nucleotide binding]; other site 648999008890 anticodon binding site; other site 648999008891 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 648999008892 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 648999008893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999008894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 648999008895 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 648999008896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999008897 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999008898 active site 648999008899 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 648999008900 active site 648999008901 multimer interface [polypeptide binding]; other site 648999008902 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 648999008903 Uncharacterized conserved protein [Function unknown]; Region: COG2128 648999008904 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 648999008905 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 648999008906 putative active site [active] 648999008907 putative metal binding site [ion binding]; other site 648999008908 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 648999008909 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 648999008910 HIGH motif; other site 648999008911 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 648999008912 active site 648999008913 KMSKS motif; other site 648999008914 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 648999008915 tRNA binding surface [nucleotide binding]; other site 648999008916 anticodon binding site; other site 648999008917 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999008918 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999008919 putative acyl-acceptor binding pocket; other site 648999008920 superantigen-like protein; Reviewed; Region: PRK13042 648999008921 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 648999008922 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 648999008923 B12 binding site [chemical binding]; other site 648999008924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999008925 FeS/SAM binding site; other site 648999008926 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999008927 active site 648999008928 catalytic residues [active] 648999008929 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 648999008930 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 648999008931 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 648999008932 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 648999008933 homodimer interface [polypeptide binding]; other site 648999008934 oligonucleotide binding site [chemical binding]; other site 648999008935 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 648999008936 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 648999008937 GTPase CgtA; Reviewed; Region: obgE; PRK12296 648999008938 GTP1/OBG; Region: GTP1_OBG; pfam01018 648999008939 Obg GTPase; Region: Obg; cd01898 648999008940 G1 box; other site 648999008941 GTP/Mg2+ binding site [chemical binding]; other site 648999008942 Switch I region; other site 648999008943 G2 box; other site 648999008944 G3 box; other site 648999008945 Switch II region; other site 648999008946 G4 box; other site 648999008947 G5 box; other site 648999008948 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 648999008949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999008950 Coenzyme A binding pocket [chemical binding]; other site 648999008951 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 648999008952 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 648999008953 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 648999008954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999008955 active site 648999008956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999008957 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999008958 Cytochrome P450; Region: p450; cl12078 648999008959 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999008960 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 648999008961 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 648999008962 Zn binding site [ion binding]; other site 648999008963 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 648999008964 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 648999008965 active site 648999008966 (T/H)XGH motif; other site 648999008967 Oligomerisation domain; Region: Oligomerisation; pfam02410 648999008968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999008969 catalytic core [active] 648999008970 EDD domain protein, DegV family; Region: DegV; TIGR00762 648999008971 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 648999008972 classical (c) SDRs; Region: SDR_c; cd05233 648999008973 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 648999008974 NAD(P) binding site [chemical binding]; other site 648999008975 active site 648999008976 SLBB domain; Region: SLBB; pfam10531 648999008977 comEA protein; Region: comE; TIGR01259 648999008978 Helix-hairpin-helix motif; Region: HHH; pfam00633 648999008979 Competence protein; Region: Competence; pfam03772 648999008980 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 648999008981 hypothetical protein; Reviewed; Region: PRK07914 648999008982 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 648999008983 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 648999008984 Phosphotransferase enzyme family; Region: APH; pfam01636 648999008985 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 648999008986 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 648999008987 GTP-binding protein LepA; Provisional; Region: PRK05433 648999008988 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 648999008989 G1 box; other site 648999008990 putative GEF interaction site [polypeptide binding]; other site 648999008991 GTP/Mg2+ binding site [chemical binding]; other site 648999008992 Switch I region; other site 648999008993 G2 box; other site 648999008994 G3 box; other site 648999008995 Switch II region; other site 648999008996 G4 box; other site 648999008997 G5 box; other site 648999008998 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 648999008999 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 648999009000 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 648999009001 Predicted membrane protein [Function unknown]; Region: COG2261 648999009002 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 648999009003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999009004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999009005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999009006 ABC-ATPase subunit interface; other site 648999009007 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999009008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999009009 dimer interface [polypeptide binding]; other site 648999009010 conserved gate region; other site 648999009011 putative PBP binding loops; other site 648999009012 ABC-ATPase subunit interface; other site 648999009013 enoyl-CoA hydratase; Provisional; Region: PRK07827 648999009014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999009015 substrate binding site [chemical binding]; other site 648999009016 oxyanion hole (OAH) forming residues; other site 648999009017 trimer interface [polypeptide binding]; other site 648999009018 coproporphyrinogen III oxidase; Validated; Region: PRK05628 648999009019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999009020 FeS/SAM binding site; other site 648999009021 Tic20-like protein; Region: Tic20; pfam09685 648999009022 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 648999009023 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 648999009024 chaperone protein DnaJ; Provisional; Region: PRK14278 648999009025 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 648999009026 HSP70 interaction site [polypeptide binding]; other site 648999009027 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 648999009028 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 648999009029 dimer interface [polypeptide binding]; other site 648999009030 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 648999009031 RNA methyltransferase, RsmE family; Region: TIGR00046 648999009032 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 648999009033 classical (c) SDRs; Region: SDR_c; cd05233 648999009034 NAD(P) binding site [chemical binding]; other site 648999009035 active site 648999009036 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 648999009037 nucleotide binding site/active site [active] 648999009038 HIT family signature motif; other site 648999009039 catalytic residue [active] 648999009040 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999009041 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999009042 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 648999009043 PhoH-like protein; Region: PhoH; pfam02562 648999009044 metal-binding heat shock protein; Provisional; Region: PRK00016 648999009045 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999009046 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999009047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999009048 Transporter associated domain; Region: CorC_HlyC; smart01091 648999009049 GTPase Era; Reviewed; Region: era; PRK00089 648999009050 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 648999009051 G1 box; other site 648999009052 GTP/Mg2+ binding site [chemical binding]; other site 648999009053 Switch I region; other site 648999009054 G2 box; other site 648999009055 Switch II region; other site 648999009056 G3 box; other site 648999009057 G4 box; other site 648999009058 G5 box; other site 648999009059 KH domain; Region: KH_2; pfam07650 648999009060 Acyltransferase family; Region: Acyl_transf_3; pfam01757 648999009061 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 648999009062 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 648999009063 Recombination protein O N terminal; Region: RecO_N; pfam11967 648999009064 Recombination protein O C terminal; Region: RecO_C; pfam02565 648999009065 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 648999009066 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 648999009067 catalytic residue [active] 648999009068 putative FPP diphosphate binding site; other site 648999009069 putative FPP binding hydrophobic cleft; other site 648999009070 dimer interface [polypeptide binding]; other site 648999009071 putative IPP diphosphate binding site; other site 648999009072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 648999009073 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 648999009074 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 648999009075 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 648999009076 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999009077 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 648999009078 Walker A/P-loop; other site 648999009079 ATP binding site [chemical binding]; other site 648999009080 Q-loop/lid; other site 648999009081 ABC transporter signature motif; other site 648999009082 Walker B; other site 648999009083 D-loop; other site 648999009084 H-loop/switch region; other site 648999009085 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 648999009086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 648999009087 Walker A/P-loop; other site 648999009088 ATP binding site [chemical binding]; other site 648999009089 Q-loop/lid; other site 648999009090 ABC transporter signature motif; other site 648999009091 Walker B; other site 648999009092 D-loop; other site 648999009093 H-loop/switch region; other site 648999009094 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 648999009095 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999009096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 648999009097 hypothetical protein; Provisional; Region: PRK02947 648999009098 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 648999009099 putative active site [active] 648999009100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999009101 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999009102 active site 648999009103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999009104 dimerization interface [polypeptide binding]; other site 648999009105 putative DNA binding site [nucleotide binding]; other site 648999009106 putative Zn2+ binding site [ion binding]; other site 648999009107 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 648999009108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999009109 dimer interface [polypeptide binding]; other site 648999009110 putative PBP binding regions; other site 648999009111 ABC-ATPase subunit interface; other site 648999009112 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 648999009113 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 648999009114 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 648999009115 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 648999009116 intersubunit interface [polypeptide binding]; other site 648999009117 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999009118 glycyl-tRNA synthetase; Provisional; Region: PRK04173 648999009119 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 648999009120 dimer interface [polypeptide binding]; other site 648999009121 motif 1; other site 648999009122 active site 648999009123 motif 2; other site 648999009124 motif 3; other site 648999009125 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 648999009126 anticodon binding site; other site 648999009127 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 648999009128 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 648999009129 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 648999009130 FMN binding site [chemical binding]; other site 648999009131 active site 648999009132 catalytic residues [active] 648999009133 substrate binding site [chemical binding]; other site 648999009134 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999009135 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 648999009136 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 648999009137 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 648999009138 active site 648999009139 pyruvate phosphate dikinase; Provisional; Region: PRK09279 648999009140 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 648999009141 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 648999009142 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 648999009143 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 648999009144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999009145 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999009146 active site 648999009147 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 648999009148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999009149 Zn2+ binding site [ion binding]; other site 648999009150 Mg2+ binding site [ion binding]; other site 648999009151 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 648999009152 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 648999009153 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 648999009154 FAD binding pocket [chemical binding]; other site 648999009155 FAD binding motif [chemical binding]; other site 648999009156 phosphate binding motif [ion binding]; other site 648999009157 NAD binding pocket [chemical binding]; other site 648999009158 BCCT family transporter; Region: BCCT; pfam02028 648999009159 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999009160 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999009161 Walker A/P-loop; other site 648999009162 ATP binding site [chemical binding]; other site 648999009163 Q-loop/lid; other site 648999009164 ABC transporter signature motif; other site 648999009165 Walker B; other site 648999009166 D-loop; other site 648999009167 H-loop/switch region; other site 648999009168 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 648999009169 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999009170 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999009171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999009172 non-specific DNA binding site [nucleotide binding]; other site 648999009173 salt bridge; other site 648999009174 sequence-specific DNA binding site [nucleotide binding]; other site 648999009175 DNA primase; Validated; Region: dnaG; PRK05667 648999009176 CHC2 zinc finger; Region: zf-CHC2; pfam01807 648999009177 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 648999009178 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 648999009179 active site 648999009180 metal binding site [ion binding]; metal-binding site 648999009181 interdomain interaction site; other site 648999009182 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 648999009183 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 648999009184 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 648999009185 putative active site [active] 648999009186 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 648999009187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999009188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999009189 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999009190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999009191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999009192 Walker A/P-loop; other site 648999009193 ATP binding site [chemical binding]; other site 648999009194 Q-loop/lid; other site 648999009195 ABC transporter signature motif; other site 648999009196 Walker B; other site 648999009197 D-loop; other site 648999009198 H-loop/switch region; other site 648999009199 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999009200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999009201 Coenzyme A binding pocket [chemical binding]; other site 648999009202 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 648999009203 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 648999009204 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 648999009205 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999009206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999009207 ATP binding site [chemical binding]; other site 648999009208 Mg2+ binding site [ion binding]; other site 648999009209 G-X-G motif; other site 648999009210 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 648999009211 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 648999009212 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 648999009213 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 648999009214 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999009215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999009216 nucleotide binding site [chemical binding]; other site 648999009217 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 648999009218 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999009219 Walker A/P-loop; other site 648999009220 ATP binding site [chemical binding]; other site 648999009221 Q-loop/lid; other site 648999009222 ABC transporter signature motif; other site 648999009223 Walker B; other site 648999009224 D-loop; other site 648999009225 H-loop/switch region; other site 648999009226 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 648999009227 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999009228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999009229 TM-ABC transporter signature motif; other site 648999009230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 648999009231 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999009232 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999009233 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999009234 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999009235 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 648999009236 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 648999009237 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999009238 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 648999009239 TatD related DNase; Region: TatD_DNase; pfam01026 648999009240 active site 648999009241 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 648999009242 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 648999009243 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999009244 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999009245 substrate binding pocket [chemical binding]; other site 648999009246 chain length determination region; other site 648999009247 substrate-Mg2+ binding site; other site 648999009248 catalytic residues [active] 648999009249 aspartate-rich region 1; other site 648999009250 active site lid residues [active] 648999009251 aspartate-rich region 2; other site 648999009252 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 648999009253 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 648999009254 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 648999009255 metal binding site [ion binding]; metal-binding site 648999009256 ligand binding site [chemical binding]; other site 648999009257 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999009258 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999009259 putative sugar binding sites [chemical binding]; other site 648999009260 Q-X-W motif; other site 648999009261 Trehalose utilisation; Region: ThuA; pfam06283 648999009262 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 648999009263 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 648999009264 metal binding site [ion binding]; metal-binding site 648999009265 ligand binding site [chemical binding]; other site 648999009266 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999009267 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999009268 putative sugar binding sites [chemical binding]; other site 648999009269 Q-X-W motif; other site 648999009270 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999009271 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 648999009272 Metal-binding active site; metal-binding site 648999009273 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 648999009274 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999009275 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999009276 nucleotide binding site [chemical binding]; other site 648999009277 MMPL family; Region: MMPL; pfam03176 648999009278 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 648999009279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999009280 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 648999009281 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999009282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999009283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999009284 DNA binding residues [nucleotide binding] 648999009285 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 648999009286 putative hydrophobic ligand binding site [chemical binding]; other site 648999009287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999009288 Coenzyme A binding pocket [chemical binding]; other site 648999009289 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 648999009290 putative hydrophobic ligand binding site [chemical binding]; other site 648999009291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999009292 dimerization interface [polypeptide binding]; other site 648999009293 putative DNA binding site [nucleotide binding]; other site 648999009294 putative Zn2+ binding site [ion binding]; other site 648999009295 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 648999009296 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999009297 FAD binding domain; Region: FAD_binding_4; pfam01565 648999009298 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 648999009299 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 648999009300 active site 648999009301 Peptidase family M50; Region: Peptidase_M50; pfam02163 648999009302 putative substrate binding region [chemical binding]; other site 648999009303 FOG: CBS domain [General function prediction only]; Region: COG0517 648999009304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 648999009305 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 648999009306 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999009307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999009308 non-specific DNA binding site [nucleotide binding]; other site 648999009309 salt bridge; other site 648999009310 sequence-specific DNA binding site [nucleotide binding]; other site 648999009311 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999009312 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 648999009313 putative active site [active] 648999009314 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 648999009315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999009316 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 648999009317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999009318 NAD(P) binding site [chemical binding]; other site 648999009319 active site 648999009320 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 648999009321 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 648999009322 active site 648999009323 Ca binding site [ion binding]; other site 648999009324 catalytic site [active] 648999009325 Aamy_C domain; Region: Aamy_C; smart00632 648999009326 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 648999009327 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 648999009328 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 648999009329 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 648999009330 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999009331 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999009332 seryl-tRNA synthetase; Provisional; Region: PRK05431 648999009333 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 648999009334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 648999009335 motif 1; other site 648999009336 dimer interface [polypeptide binding]; other site 648999009337 active site 648999009338 motif 2; other site 648999009339 motif 3; other site 648999009340 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 648999009341 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999009342 DNA binding residues [nucleotide binding] 648999009343 drug binding residues [chemical binding]; other site 648999009344 dimer interface [polypeptide binding]; other site 648999009345 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 648999009346 beta-clamp/clamp loader binding surface; other site 648999009347 beta-clamp/translesion DNA polymerase binding surface; other site 648999009348 Uncharacterized conserved protein [Function unknown]; Region: COG3268 648999009349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999009350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 648999009351 NAD(P) binding site [chemical binding]; other site 648999009352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999009353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999009354 DNA binding residues [nucleotide binding] 648999009355 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 648999009356 Thioredoxin; Region: Thioredoxin_4; pfam13462 648999009357 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999009358 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999009359 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 648999009360 BON domain; Region: BON; pfam04972 648999009361 BON domain; Region: BON; pfam04972 648999009362 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999009363 anti sigma factor interaction site; other site 648999009364 regulatory phosphorylation site [posttranslational modification]; other site 648999009365 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999009366 hydrophobic ligand binding site; other site 648999009367 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 648999009368 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 648999009369 Part of AAA domain; Region: AAA_19; pfam13245 648999009370 Family description; Region: UvrD_C_2; pfam13538 648999009371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999009372 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 648999009373 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 648999009374 active site clefts [active] 648999009375 zinc binding site [ion binding]; other site 648999009376 dimer interface [polypeptide binding]; other site 648999009377 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 648999009378 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 648999009379 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 648999009380 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 648999009381 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999009382 dimer interface [polypeptide binding]; other site 648999009383 active site 648999009384 acyl carrier protein; Provisional; Region: acpP; PRK00982 648999009385 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 648999009386 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 648999009387 dimer interface [polypeptide binding]; other site 648999009388 active site 648999009389 CoA binding pocket [chemical binding]; other site 648999009390 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 648999009391 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999009392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999009393 E3 interaction surface; other site 648999009394 lipoyl attachment site [posttranslational modification]; other site 648999009395 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999009396 CopC domain; Region: CopC; pfam04234 648999009397 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 648999009398 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999009399 active site 648999009400 HIGH motif; other site 648999009401 nucleotide binding site [chemical binding]; other site 648999009402 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 648999009403 active site 648999009404 KMSKS motif; other site 648999009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999009406 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999009407 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999009408 beta-galactosidase; Region: BGL; TIGR03356 648999009409 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 648999009410 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 648999009411 dimer interface [polypeptide binding]; other site 648999009412 TPP-binding site [chemical binding]; other site 648999009413 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 648999009414 PhoD-like phosphatase; Region: PhoD; pfam09423 648999009415 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 648999009416 putative active site [active] 648999009417 putative metal binding site [ion binding]; other site 648999009418 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 648999009419 MarR family; Region: MarR; pfam01047 648999009420 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 648999009421 TPP-binding site [chemical binding]; other site 648999009422 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999009423 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 648999009424 PYR/PP interface [polypeptide binding]; other site 648999009425 dimer interface [polypeptide binding]; other site 648999009426 TPP binding site [chemical binding]; other site 648999009427 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999009428 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 648999009429 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 648999009430 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 648999009431 dimer interface [polypeptide binding]; other site 648999009432 catalytic triad [active] 648999009433 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 648999009434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999009435 Walker A/P-loop; other site 648999009436 ATP binding site [chemical binding]; other site 648999009437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999009438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999009439 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 648999009440 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 648999009441 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 648999009442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999009443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999009444 sequence-specific DNA binding site [nucleotide binding]; other site 648999009445 salt bridge; other site 648999009446 Cupin domain; Region: Cupin_2; pfam07883 648999009447 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999009448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 648999009449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999009450 putative substrate translocation pore; other site 648999009451 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999009452 MarR family; Region: MarR; pfam01047 648999009453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999009454 Ligand Binding Site [chemical binding]; other site 648999009455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 648999009456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 648999009457 ligand binding site [chemical binding]; other site 648999009458 flexible hinge region; other site 648999009459 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 648999009460 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 648999009461 cyclase homology domain; Region: CHD; cd07302 648999009462 nucleotidyl binding site; other site 648999009463 metal binding site [ion binding]; metal-binding site 648999009464 dimer interface [polypeptide binding]; other site 648999009465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999009466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999009467 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999009468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999009469 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999009470 Phosphotransferase enzyme family; Region: APH; pfam01636 648999009471 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999009472 active site 648999009473 ATP binding site [chemical binding]; other site 648999009474 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999009475 RibD C-terminal domain; Region: RibD_C; cl17279 648999009476 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 648999009477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999009478 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 648999009479 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999009480 DinB superfamily; Region: DinB_2; pfam12867 648999009481 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999009482 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 648999009483 SNF2 Helicase protein; Region: DUF3670; pfam12419 648999009484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999009485 ATP binding site [chemical binding]; other site 648999009486 putative Mg++ binding site [ion binding]; other site 648999009487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999009488 nucleotide binding region [chemical binding]; other site 648999009489 ATP-binding site [chemical binding]; other site 648999009490 Uncharacterized conserved protein [Function unknown]; Region: COG4279 648999009491 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 648999009492 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 648999009493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 648999009494 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 648999009495 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 648999009496 FAD binding pocket [chemical binding]; other site 648999009497 FAD binding motif [chemical binding]; other site 648999009498 phosphate binding motif [ion binding]; other site 648999009499 beta-alpha-beta structure motif; other site 648999009500 NAD binding pocket [chemical binding]; other site 648999009501 FMN-binding domain; Region: FMN_bind; pfam04205 648999009502 ApbE family; Region: ApbE; pfam02424 648999009503 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 648999009504 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999009505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999009506 non-specific DNA binding site [nucleotide binding]; other site 648999009507 salt bridge; other site 648999009508 sequence-specific DNA binding site [nucleotide binding]; other site 648999009509 Flavoprotein; Region: Flavoprotein; pfam02441 648999009510 Uncharacterized conserved protein [Function unknown]; Region: COG0327 648999009511 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 648999009512 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 648999009513 Putative zinc ribbon domain; Region: DUF164; pfam02591 648999009514 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 648999009515 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 648999009516 RNA/DNA hybrid binding site [nucleotide binding]; other site 648999009517 active site 648999009518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999009519 catalytic core [active] 648999009520 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 648999009521 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 648999009522 Na binding site [ion binding]; other site 648999009523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999009524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999009525 putative DNA binding site [nucleotide binding]; other site 648999009526 putative Zn2+ binding site [ion binding]; other site 648999009527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999009528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999009529 putative substrate translocation pore; other site 648999009530 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 648999009531 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 648999009532 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999009533 active site 648999009534 metal binding site [ion binding]; metal-binding site 648999009535 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 648999009536 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 648999009537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999009538 catalytic residue [active] 648999009539 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999009540 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999009541 RNB domain; Region: RNB; pfam00773 648999009542 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 648999009543 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 648999009544 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 648999009545 oligomerization interface [polypeptide binding]; other site 648999009546 active site 648999009547 metal binding site [ion binding]; metal-binding site 648999009548 NAD synthetase; Provisional; Region: PRK13981 648999009549 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 648999009550 multimer interface [polypeptide binding]; other site 648999009551 active site 648999009552 catalytic triad [active] 648999009553 protein interface 1 [polypeptide binding]; other site 648999009554 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 648999009555 homodimer interface [polypeptide binding]; other site 648999009556 NAD binding pocket [chemical binding]; other site 648999009557 ATP binding pocket [chemical binding]; other site 648999009558 Mg binding site [ion binding]; other site 648999009559 active-site loop [active] 648999009560 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 648999009561 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 648999009562 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 648999009563 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 648999009564 HTH domain; Region: HTH_11; pfam08279 648999009565 WYL domain; Region: WYL; pfam13280 648999009566 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 648999009567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999009568 Carbohydrate binding domain; Region: CBM_25; smart01066 648999009569 Carbohydrate binding domain; Region: CBM_25; smart01066 648999009570 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 648999009571 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 648999009572 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 648999009573 active site 648999009574 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 648999009575 active site 648999009576 catalytic site [active] 648999009577 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 648999009578 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 648999009579 dimer interface [polypeptide binding]; other site 648999009580 catalytic triad [active] 648999009581 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 648999009582 catalytic triad [active] 648999009583 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 648999009584 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 648999009585 metal binding triad; other site 648999009586 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 648999009587 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 648999009588 metal binding triad; other site 648999009589 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 648999009590 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 648999009591 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 648999009592 AAA domain; Region: AAA_33; pfam13671 648999009593 glutamine synthetase, type I; Region: GlnA; TIGR00653 648999009594 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 648999009595 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 648999009596 RDD family; Region: RDD; pfam06271 648999009597 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 648999009598 AAA ATPase domain; Region: AAA_16; pfam13191 648999009599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999009600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999009601 DNA binding residues [nucleotide binding] 648999009602 dimerization interface [polypeptide binding]; other site 648999009603 lipoyl synthase; Provisional; Region: PRK05481 648999009604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999009605 FeS/SAM binding site; other site 648999009606 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 648999009607 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 648999009608 Dimer interface [polypeptide binding]; other site 648999009609 anticodon binding site; other site 648999009610 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 648999009611 motif 1; other site 648999009612 dimer interface [polypeptide binding]; other site 648999009613 active site 648999009614 motif 2; other site 648999009615 motif 3; other site 648999009616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999009617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 648999009618 lipoate-protein ligase B; Provisional; Region: PRK14345 648999009619 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 648999009620 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 648999009621 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 648999009622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999009623 NAD(P) binding site [chemical binding]; other site 648999009624 active site 648999009625 DNA binding domain, excisionase family; Region: excise; TIGR01764 648999009626 PIN domain; Region: PIN_3; pfam13470 648999009627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999009628 active site 648999009629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999009630 catalytic tetrad [active] 648999009631 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 648999009632 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999009633 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999009634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999009635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999009636 oxidoreductase; Provisional; Region: PRK06196 648999009637 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 648999009638 putative NAD(P) binding site [chemical binding]; other site 648999009639 active site 648999009640 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999009641 E3 interaction surface; other site 648999009642 lipoyl attachment site [posttranslational modification]; other site 648999009643 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999009644 E3 interaction surface; other site 648999009645 lipoyl attachment site [posttranslational modification]; other site 648999009646 e3 binding domain; Region: E3_binding; pfam02817 648999009647 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 648999009648 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999009649 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 648999009650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999009651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999009652 multifunctional aminopeptidase A; Provisional; Region: PRK00913 648999009653 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 648999009654 interface (dimer of trimers) [polypeptide binding]; other site 648999009655 Substrate-binding/catalytic site; other site 648999009656 Zn-binding sites [ion binding]; other site 648999009657 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 648999009658 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 648999009659 cobalamin synthase; Reviewed; Region: cobS; PRK00235 648999009660 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 648999009661 homotrimer interface [polypeptide binding]; other site 648999009662 Walker A motif; other site 648999009663 GTP binding site [chemical binding]; other site 648999009664 Walker B motif; other site 648999009665 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 648999009666 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 648999009667 active site pocket [active] 648999009668 putative cataytic base [active] 648999009669 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 648999009670 Peptidase family M50; Region: Peptidase_M50; pfam02163 648999009671 active site 648999009672 putative substrate binding region [chemical binding]; other site 648999009673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999009674 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999009675 active site 648999009676 catalytic tetrad [active] 648999009677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999009678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999009679 Cupin domain; Region: Cupin_2; pfam07883 648999009680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999009681 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 648999009682 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 648999009683 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 648999009684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999009685 Walker A/P-loop; other site 648999009686 ATP binding site [chemical binding]; other site 648999009687 Q-loop/lid; other site 648999009688 ABC transporter signature motif; other site 648999009689 Walker B; other site 648999009690 D-loop; other site 648999009691 H-loop/switch region; other site 648999009692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999009693 sequence-specific DNA binding site [nucleotide binding]; other site 648999009694 salt bridge; other site 648999009695 Cupin domain; Region: Cupin_2; pfam07883 648999009696 AzlC protein; Region: AzlC; pfam03591 648999009697 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 648999009698 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 648999009699 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 648999009700 hinge; other site 648999009701 active site 648999009702 quinolinate synthetase; Provisional; Region: PRK09375 648999009703 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 648999009704 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 648999009705 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 648999009706 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 648999009707 substrate binding site [chemical binding]; other site 648999009708 ATP binding site [chemical binding]; other site 648999009709 AAA domain; Region: AAA_33; pfam13671 648999009710 AAA domain; Region: AAA_17; pfam13207 648999009711 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 648999009712 CPxP motif; other site 648999009713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999009714 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 648999009715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999009716 catalytic residue [active] 648999009717 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 648999009718 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 648999009719 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 648999009720 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 648999009721 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 648999009722 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 648999009723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 648999009724 phosphorylation site [posttranslational modification] 648999009725 intermolecular recognition site; other site 648999009726 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 648999009727 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 648999009728 Subunit I/III interface [polypeptide binding]; other site 648999009729 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 648999009730 Cytochrome c; Region: Cytochrom_C; pfam00034 648999009731 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 648999009732 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 648999009733 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 648999009734 iron-sulfur cluster [ion binding]; other site 648999009735 [2Fe-2S] cluster binding site [ion binding]; other site 648999009736 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 648999009737 intrachain domain interface; other site 648999009738 interchain domain interface [polypeptide binding]; other site 648999009739 heme bL binding site [chemical binding]; other site 648999009740 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 648999009741 heme bH binding site [chemical binding]; other site 648999009742 Qo binding site; other site 648999009743 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 648999009744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 648999009745 AsnC family; Region: AsnC_trans_reg; pfam01037 648999009746 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 648999009747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999009748 active site 648999009749 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 648999009750 putative trimer interface [polypeptide binding]; other site 648999009751 putative CoA binding site [chemical binding]; other site 648999009752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999009753 nudix motif; other site 648999009754 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 648999009755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999009756 Zn2+ binding site [ion binding]; other site 648999009757 Mg2+ binding site [ion binding]; other site 648999009758 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 648999009759 synthetase active site [active] 648999009760 NTP binding site [chemical binding]; other site 648999009761 metal binding site [ion binding]; metal-binding site 648999009762 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 648999009763 hypothetical protein; Validated; Region: PRK07883 648999009764 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 648999009765 active site 648999009766 catalytic site [active] 648999009767 substrate binding site [chemical binding]; other site 648999009768 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 648999009769 GIY-YIG motif/motif A; other site 648999009770 active site 648999009771 catalytic site [active] 648999009772 putative DNA binding site [nucleotide binding]; other site 648999009773 metal binding site [ion binding]; metal-binding site 648999009774 YacP-like NYN domain; Region: NYN_YacP; cl01491 648999009775 Peptidase family M48; Region: Peptidase_M48; cl12018 648999009776 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999009777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999009778 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999009779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999009780 metal binding site [ion binding]; metal-binding site 648999009781 active site 648999009782 I-site; other site 648999009783 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999009784 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999009785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999009786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999009787 active site 648999009788 phosphorylation site [posttranslational modification] 648999009789 intermolecular recognition site; other site 648999009790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999009791 DNA binding residues [nucleotide binding] 648999009792 dimerization interface [polypeptide binding]; other site 648999009793 GAF domain; Region: GAF_3; pfam13492 648999009794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999009795 Histidine kinase; Region: HisKA_3; pfam07730 648999009796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999009797 ATP binding site [chemical binding]; other site 648999009798 Mg2+ binding site [ion binding]; other site 648999009799 G-X-G motif; other site 648999009800 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 648999009801 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 648999009802 acyl-activating enzyme (AAE) consensus motif; other site 648999009803 putative AMP binding site [chemical binding]; other site 648999009804 putative active site [active] 648999009805 putative CoA binding site [chemical binding]; other site 648999009806 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 648999009807 putative hydrophobic ligand binding site [chemical binding]; other site 648999009808 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 648999009809 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999009810 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999009811 putative catalytic site [active] 648999009812 putative metal binding site [ion binding]; other site 648999009813 putative phosphate binding site [ion binding]; other site 648999009814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 648999009815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 648999009816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999009817 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 648999009818 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 648999009819 active site 648999009820 homotetramer interface [polypeptide binding]; other site 648999009821 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 648999009822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999009823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999009824 putative acyl-acceptor binding pocket; other site 648999009825 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 648999009826 cyclase homology domain; Region: CHD; cd07302 648999009827 nucleotidyl binding site; other site 648999009828 metal binding site [ion binding]; metal-binding site 648999009829 dimer interface [polypeptide binding]; other site 648999009830 AAA ATPase domain; Region: AAA_16; pfam13191 648999009831 AAA domain; Region: AAA_22; pfam13401 648999009832 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 648999009833 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 648999009834 ligand binding site [chemical binding]; other site 648999009835 flexible hinge region; other site 648999009836 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 648999009837 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 648999009838 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999009839 phosphofructokinase; Region: PFK_mixed; TIGR02483 648999009840 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 648999009841 active site 648999009842 ADP/pyrophosphate binding site [chemical binding]; other site 648999009843 dimerization interface [polypeptide binding]; other site 648999009844 allosteric effector site; other site 648999009845 fructose-1,6-bisphosphate binding site; other site 648999009846 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 648999009847 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 648999009848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999009849 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 648999009850 putative substrate translocation pore; other site 648999009851 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 648999009852 alpha-gamma subunit interface [polypeptide binding]; other site 648999009853 beta-gamma subunit interface [polypeptide binding]; other site 648999009854 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 648999009855 alpha-beta subunit interface [polypeptide binding]; other site 648999009856 urease subunit alpha; Reviewed; Region: ureC; PRK13207 648999009857 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 648999009858 subunit interactions [polypeptide binding]; other site 648999009859 active site 648999009860 flap region; other site 648999009861 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 648999009862 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 648999009863 dimer interface [polypeptide binding]; other site 648999009864 catalytic residues [active] 648999009865 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 648999009866 UreF; Region: UreF; pfam01730 648999009867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999009868 UreD urease accessory protein; Region: UreD; cl00530 648999009869 Urea transporter; Region: UT; cl01829 648999009870 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 648999009871 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 648999009872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999009873 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 648999009874 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 648999009875 putative active site [active] 648999009876 putative metal binding site [ion binding]; other site 648999009877 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 648999009878 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 648999009879 active site 648999009880 catalytic triad [active] 648999009881 oxyanion hole [active] 648999009882 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 648999009883 catalytic residues [active] 648999009884 dimer interface [polypeptide binding]; other site 648999009885 CBD_II domain; Region: CBD_II; smart00637 648999009886 Glyco_18 domain; Region: Glyco_18; smart00636 648999009887 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 648999009888 active site 648999009889 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 648999009890 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 648999009891 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 648999009892 tetramer interface [polypeptide binding]; other site 648999009893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999009894 catalytic residue [active] 648999009895 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 648999009896 AP endonuclease family 2; Region: AP2Ec; smart00518 648999009897 AP (apurinic/apyrimidinic) site pocket; other site 648999009898 DNA interaction; other site 648999009899 Metal-binding active site; metal-binding site 648999009900 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999009901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999009902 active site 648999009903 ATP binding site [chemical binding]; other site 648999009904 substrate binding site [chemical binding]; other site 648999009905 activation loop (A-loop); other site 648999009906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 648999009907 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999009908 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999009909 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 648999009910 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999009911 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999009912 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999009913 substrate binding pocket [chemical binding]; other site 648999009914 chain length determination region; other site 648999009915 substrate-Mg2+ binding site; other site 648999009916 catalytic residues [active] 648999009917 aspartate-rich region 1; other site 648999009918 active site lid residues [active] 648999009919 aspartate-rich region 2; other site 648999009920 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 648999009921 FAD binding site [chemical binding]; other site 648999009922 phytoene desaturase; Region: crtI_fam; TIGR02734 648999009923 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 648999009924 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 648999009925 active site 648999009926 Protein of unknown function (DUF422); Region: DUF422; cl00991 648999009927 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 648999009928 putative deacylase active site [active] 648999009929 DNA Polymerase Y-family; Region: PolY_like; cd03468 648999009930 active site 648999009931 DNA binding site [nucleotide binding] 648999009932 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 648999009933 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 648999009934 active site 648999009935 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 648999009936 generic binding surface II; other site 648999009937 generic binding surface I; other site 648999009938 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999009939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999009940 S-adenosylmethionine binding site [chemical binding]; other site 648999009941 Uncharacterized conserved protein [Function unknown]; Region: COG3379 648999009942 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 648999009943 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 648999009944 active site 648999009945 DNA polymerase IV; Validated; Region: PRK02406 648999009946 DNA binding site [nucleotide binding] 648999009947 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 648999009948 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 648999009949 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 648999009950 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 648999009951 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999009952 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999009953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999009954 Walker A motif; other site 648999009955 ATP binding site [chemical binding]; other site 648999009956 Walker B motif; other site 648999009957 arginine finger; other site 648999009958 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 648999009959 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 648999009960 HIGH motif; other site 648999009961 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 648999009962 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999009963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999009964 active site 648999009965 KMSKS motif; other site 648999009966 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 648999009967 tRNA binding surface [nucleotide binding]; other site 648999009968 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999009969 Uncharacterized conserved protein [Function unknown]; Region: COG0398 648999009970 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 648999009971 catalytic triad [active] 648999009972 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 648999009973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999009974 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 648999009975 cell division protein MraZ; Reviewed; Region: PRK00326 648999009976 MraZ protein; Region: MraZ; pfam02381 648999009977 MraZ protein; Region: MraZ; pfam02381 648999009978 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 648999009979 MraW methylase family; Region: Methyltransf_5; cl17771 648999009980 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 648999009981 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 648999009982 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 648999009983 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 648999009984 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 648999009985 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999009986 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 648999009987 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 648999009988 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 648999009989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999009990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 648999009991 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 648999009992 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 648999009993 Mg++ binding site [ion binding]; other site 648999009994 putative catalytic motif [active] 648999009995 putative substrate binding site [chemical binding]; other site 648999009996 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 648999009997 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 648999009998 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 648999009999 active site 648999010000 homodimer interface [polypeptide binding]; other site 648999010001 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 648999010002 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 648999010003 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999010004 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 648999010005 cell division protein FtsQ; Provisional; Region: PRK05529 648999010006 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 648999010007 cell division protein FtsZ; Validated; Region: PRK09330 648999010008 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 648999010009 nucleotide binding site [chemical binding]; other site 648999010010 SulA interaction site; other site 648999010011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 648999010012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999010013 catalytic residue [active] 648999010014 Protein of unknown function (DUF552); Region: DUF552; pfam04472 648999010015 YGGT family; Region: YGGT; pfam02325 648999010016 DivIVA protein; Region: DivIVA; pfam05103 648999010017 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999010018 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 648999010019 potassium/proton antiporter; Reviewed; Region: PRK05326 648999010020 TrkA-C domain; Region: TrkA_C; pfam02080 648999010021 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 648999010022 lipoprotein signal peptidase; Provisional; Region: PRK14764 648999010023 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 648999010024 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 648999010025 active site 648999010026 AAA domain; Region: AAA_31; pfam13614 648999010027 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 648999010028 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 648999010029 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 648999010030 NAD binding site [chemical binding]; other site 648999010031 dimerization interface [polypeptide binding]; other site 648999010032 product binding site; other site 648999010033 substrate binding site [chemical binding]; other site 648999010034 zinc binding site [ion binding]; other site 648999010035 catalytic residues [active] 648999010036 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 648999010037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999010038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999010039 homodimer interface [polypeptide binding]; other site 648999010040 catalytic residue [active] 648999010041 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 648999010042 putative active site pocket [active] 648999010043 4-fold oligomerization interface [polypeptide binding]; other site 648999010044 metal binding residues [ion binding]; metal-binding site 648999010045 3-fold/trimer interface [polypeptide binding]; other site 648999010046 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 648999010047 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 648999010048 putative active site [active] 648999010049 oxyanion strand; other site 648999010050 catalytic triad [active] 648999010051 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 648999010052 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 648999010053 catalytic residues [active] 648999010054 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 648999010055 homotrimer interaction site [polypeptide binding]; other site 648999010056 putative active site [active] 648999010057 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999010058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010059 putative Zn2+ binding site [ion binding]; other site 648999010060 putative DNA binding site [nucleotide binding]; other site 648999010061 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 648999010062 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 648999010063 Prostaglandin dehydrogenases; Region: PGDH; cd05288 648999010064 NAD(P) binding site [chemical binding]; other site 648999010065 substrate binding site [chemical binding]; other site 648999010066 dimer interface [polypeptide binding]; other site 648999010067 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 648999010068 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 648999010069 substrate binding site [chemical binding]; other site 648999010070 glutamase interaction surface [polypeptide binding]; other site 648999010071 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 648999010072 Predicted membrane protein [Function unknown]; Region: COG2364 648999010073 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999010074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999010075 DNA-binding site [nucleotide binding]; DNA binding site 648999010076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999010077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999010078 homodimer interface [polypeptide binding]; other site 648999010079 catalytic residue [active] 648999010080 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999010081 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 648999010082 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 648999010083 acyl-activating enzyme (AAE) consensus motif; other site 648999010084 putative AMP binding site [chemical binding]; other site 648999010085 putative active site [active] 648999010086 putative CoA binding site [chemical binding]; other site 648999010087 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 648999010088 substrate binding pocket [chemical binding]; other site 648999010089 substrate-Mg2+ binding site; other site 648999010090 aspartate-rich region 1; other site 648999010091 aspartate-rich region 2; other site 648999010092 TIGR03085 family protein; Region: TIGR03085 648999010093 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999010094 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 648999010095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999010096 Walker A/P-loop; other site 648999010097 ATP binding site [chemical binding]; other site 648999010098 Q-loop/lid; other site 648999010099 ABC transporter signature motif; other site 648999010100 Walker B; other site 648999010101 D-loop; other site 648999010102 H-loop/switch region; other site 648999010103 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 648999010104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999010105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999010106 Walker A/P-loop; other site 648999010107 ATP binding site [chemical binding]; other site 648999010108 Q-loop/lid; other site 648999010109 ABC transporter signature motif; other site 648999010110 Walker B; other site 648999010111 D-loop; other site 648999010112 H-loop/switch region; other site 648999010113 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 648999010114 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 648999010115 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 648999010116 RNA binding surface [nucleotide binding]; other site 648999010117 transcriptional regulator BetI; Validated; Region: PRK00767 648999010118 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999010119 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999010120 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 648999010121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999010122 Walker A/P-loop; other site 648999010123 ATP binding site [chemical binding]; other site 648999010124 Q-loop/lid; other site 648999010125 ABC transporter signature motif; other site 648999010126 Walker B; other site 648999010127 D-loop; other site 648999010128 H-loop/switch region; other site 648999010129 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 648999010130 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 648999010131 DNA binding residues [nucleotide binding] 648999010132 putative dimer interface [polypeptide binding]; other site 648999010133 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 648999010134 anthranilate synthase component I; Provisional; Region: PRK13571 648999010135 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 648999010136 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 648999010137 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 648999010138 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 648999010139 active site 648999010140 ribulose/triose binding site [chemical binding]; other site 648999010141 phosphate binding site [ion binding]; other site 648999010142 substrate (anthranilate) binding pocket [chemical binding]; other site 648999010143 product (indole) binding pocket [chemical binding]; other site 648999010144 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 648999010145 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 648999010146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999010147 catalytic residue [active] 648999010148 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 648999010149 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 648999010150 substrate binding site [chemical binding]; other site 648999010151 active site 648999010152 catalytic residues [active] 648999010153 heterodimer interface [polypeptide binding]; other site 648999010154 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999010155 nudix motif; other site 648999010156 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 648999010157 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999010158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999010159 Coenzyme A binding pocket [chemical binding]; other site 648999010160 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 648999010161 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 648999010162 active site 648999010163 dimer interface [polypeptide binding]; other site 648999010164 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 648999010165 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 648999010166 active site 648999010167 FMN binding site [chemical binding]; other site 648999010168 substrate binding site [chemical binding]; other site 648999010169 3Fe-4S cluster binding site [ion binding]; other site 648999010170 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 648999010171 domain interface; other site 648999010172 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 648999010173 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 648999010174 Peptidase family M1; Region: Peptidase_M1; pfam01433 648999010175 Zn binding site [ion binding]; other site 648999010176 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 648999010177 active site 648999010178 catalytic triad [active] 648999010179 oxyanion hole [active] 648999010180 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999010181 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 648999010182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999010183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999010184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999010185 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 648999010186 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999010187 Lipase (class 2); Region: Lipase_2; pfam01674 648999010188 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 648999010189 choline dehydrogenase; Validated; Region: PRK02106 648999010190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999010191 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 648999010192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999010193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999010194 active site 648999010195 catalytic tetrad [active] 648999010196 YCII-related domain; Region: YCII; cl00999 648999010197 pyruvate kinase; Provisional; Region: PRK06247 648999010198 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 648999010199 domain interfaces; other site 648999010200 active site 648999010201 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 648999010202 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 648999010203 active site 648999010204 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 648999010205 catalytic triad [active] 648999010206 dimer interface [polypeptide binding]; other site 648999010207 Predicted transcriptional regulator [Transcription]; Region: COG1959 648999010208 Transcriptional regulator; Region: Rrf2; pfam02082 648999010209 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 648999010210 Cellulose binding domain; Region: CBM_2; pfam00553 648999010211 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 648999010212 metal binding site [ion binding]; metal-binding site 648999010213 active site 648999010214 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 648999010215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999010216 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 648999010217 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 648999010218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010219 putative DNA binding site [nucleotide binding]; other site 648999010220 putative Zn2+ binding site [ion binding]; other site 648999010221 AsnC family; Region: AsnC_trans_reg; pfam01037 648999010222 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 648999010223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999010224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999010225 catalytic residue [active] 648999010226 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 648999010227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999010228 active site 648999010229 phosphorylation site [posttranslational modification] 648999010230 intermolecular recognition site; other site 648999010231 dimerization interface [polypeptide binding]; other site 648999010232 ANTAR domain; Region: ANTAR; pfam03861 648999010233 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 648999010234 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 648999010235 dimerization interface [polypeptide binding]; other site 648999010236 ligand binding site [chemical binding]; other site 648999010237 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 648999010238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999010239 TM-ABC transporter signature motif; other site 648999010240 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 648999010241 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 648999010242 TM-ABC transporter signature motif; other site 648999010243 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 648999010244 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 648999010245 Walker A/P-loop; other site 648999010246 ATP binding site [chemical binding]; other site 648999010247 Q-loop/lid; other site 648999010248 ABC transporter signature motif; other site 648999010249 Walker B; other site 648999010250 D-loop; other site 648999010251 H-loop/switch region; other site 648999010252 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 648999010253 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 648999010254 Walker A/P-loop; other site 648999010255 ATP binding site [chemical binding]; other site 648999010256 Q-loop/lid; other site 648999010257 ABC transporter signature motif; other site 648999010258 Walker B; other site 648999010259 D-loop; other site 648999010260 H-loop/switch region; other site 648999010261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999010262 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 648999010263 substrate binding pocket [chemical binding]; other site 648999010264 membrane-bound complex binding site; other site 648999010265 hinge residues; other site 648999010266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 648999010268 dimer interface [polypeptide binding]; other site 648999010269 conserved gate region; other site 648999010270 putative PBP binding loops; other site 648999010271 ABC-ATPase subunit interface; other site 648999010272 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 648999010273 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 648999010274 Walker A/P-loop; other site 648999010275 ATP binding site [chemical binding]; other site 648999010276 Q-loop/lid; other site 648999010277 ABC transporter signature motif; other site 648999010278 Walker B; other site 648999010279 D-loop; other site 648999010280 H-loop/switch region; other site 648999010281 DNA polymerase I; Provisional; Region: PRK05755 648999010282 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 648999010283 active site 648999010284 metal binding site 1 [ion binding]; metal-binding site 648999010285 putative 5' ssDNA interaction site; other site 648999010286 metal binding site 3; metal-binding site 648999010287 metal binding site 2 [ion binding]; metal-binding site 648999010288 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 648999010289 putative DNA binding site [nucleotide binding]; other site 648999010290 putative metal binding site [ion binding]; other site 648999010291 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 648999010292 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 648999010293 active site 648999010294 DNA binding site [nucleotide binding] 648999010295 catalytic site [active] 648999010296 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 648999010297 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999010298 DNA binding residues [nucleotide binding] 648999010299 putative dimer interface [polypeptide binding]; other site 648999010300 classical (c) SDRs; Region: SDR_c; cd05233 648999010301 NAD(P) binding site [chemical binding]; other site 648999010302 active site 648999010303 CAAX protease self-immunity; Region: Abi; pfam02517 648999010304 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 648999010305 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 648999010306 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 648999010307 putative active site [active] 648999010308 Methyltransferase domain; Region: Methyltransf_11; pfam08241 648999010309 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 648999010310 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 648999010311 RNA binding site [nucleotide binding]; other site 648999010312 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 648999010313 RNA binding site [nucleotide binding]; other site 648999010314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 648999010315 RNA binding site [nucleotide binding]; other site 648999010316 S1 RNA binding domain; Region: S1; pfam00575 648999010317 RNA binding site [nucleotide binding]; other site 648999010318 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 648999010319 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 648999010320 CoA-binding site [chemical binding]; other site 648999010321 ATP-binding [chemical binding]; other site 648999010322 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 648999010323 excinuclease ABC subunit B; Provisional; Region: PRK05298 648999010324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999010325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999010326 nucleotide binding region [chemical binding]; other site 648999010327 ATP-binding site [chemical binding]; other site 648999010328 Ultra-violet resistance protein B; Region: UvrB; pfam12344 648999010329 UvrB/uvrC motif; Region: UVR; pfam02151 648999010330 Helix-turn-helix domain; Region: HTH_18; pfam12833 648999010331 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 648999010332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999010333 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 648999010334 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 648999010335 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999010336 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999010337 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 648999010338 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 648999010339 metal binding site [ion binding]; metal-binding site 648999010340 substrate binding pocket [chemical binding]; other site 648999010341 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 648999010342 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 648999010343 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 648999010344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999010345 S-adenosylmethionine binding site [chemical binding]; other site 648999010346 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 648999010347 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 648999010348 G1 box; other site 648999010349 putative GEF interaction site [polypeptide binding]; other site 648999010350 GTP/Mg2+ binding site [chemical binding]; other site 648999010351 Switch I region; other site 648999010352 G2 box; other site 648999010353 G3 box; other site 648999010354 Switch II region; other site 648999010355 G4 box; other site 648999010356 G5 box; other site 648999010357 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 648999010358 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 648999010359 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999010360 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 648999010361 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 648999010362 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 648999010363 N-acetyl-D-glucosamine binding site [chemical binding]; other site 648999010364 catalytic residue [active] 648999010365 MMPL family; Region: MMPL; pfam03176 648999010366 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999010367 MarR family; Region: MarR; pfam01047 648999010368 Predicted acyl esterases [General function prediction only]; Region: COG2936 648999010369 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 648999010370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010371 putative DNA binding site [nucleotide binding]; other site 648999010372 putative Zn2+ binding site [ion binding]; other site 648999010373 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999010374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999010375 DNA-binding site [nucleotide binding]; DNA binding site 648999010376 RNA-binding motif; other site 648999010377 Predicted methyltransferase [General function prediction only]; Region: COG3897 648999010378 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999010379 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 648999010380 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 648999010381 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 648999010382 Predicted GTPases [General function prediction only]; Region: COG1162 648999010383 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 648999010384 RNA binding site [nucleotide binding]; other site 648999010385 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 648999010386 GTPase/Zn-binding domain interface [polypeptide binding]; other site 648999010387 GTP/Mg2+ binding site [chemical binding]; other site 648999010388 G4 box; other site 648999010389 G5 box; other site 648999010390 G1 box; other site 648999010391 Switch I region; other site 648999010392 G2 box; other site 648999010393 G3 box; other site 648999010394 Switch II region; other site 648999010395 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 648999010396 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 648999010397 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 648999010398 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 648999010399 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 648999010400 iron-sulfur cluster [ion binding]; other site 648999010401 [2Fe-2S] cluster binding site [ion binding]; other site 648999010402 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 648999010403 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 648999010404 GIY-YIG motif/motif A; other site 648999010405 active site 648999010406 catalytic site [active] 648999010407 putative DNA binding site [nucleotide binding]; other site 648999010408 metal binding site [ion binding]; metal-binding site 648999010409 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 648999010410 Helix-hairpin-helix motif; Region: HHH; pfam00633 648999010411 helix-hairpin-helix signature motif; other site 648999010412 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999010413 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 648999010414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999010415 ATP binding site [chemical binding]; other site 648999010416 putative Mg++ binding site [ion binding]; other site 648999010417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999010418 nucleotide binding region [chemical binding]; other site 648999010419 ATP-binding site [chemical binding]; other site 648999010420 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 648999010421 HRDC domain; Region: HRDC; pfam00570 648999010422 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 648999010423 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 648999010424 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 648999010425 phosphate binding site [ion binding]; other site 648999010426 putative substrate binding pocket [chemical binding]; other site 648999010427 dimer interface [polypeptide binding]; other site 648999010428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 648999010429 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 648999010430 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 648999010431 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 648999010432 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 648999010433 Phosphoglycerate kinase; Region: PGK; pfam00162 648999010434 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 648999010435 substrate binding site [chemical binding]; other site 648999010436 hinge regions; other site 648999010437 ADP binding site [chemical binding]; other site 648999010438 catalytic site [active] 648999010439 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 648999010440 triosephosphate isomerase; Provisional; Region: PRK14567 648999010441 substrate binding site [chemical binding]; other site 648999010442 dimer interface [polypeptide binding]; other site 648999010443 catalytic triad [active] 648999010444 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 648999010445 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 648999010446 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 648999010447 putative active site [active] 648999010448 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 648999010449 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 648999010450 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 648999010451 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 648999010452 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 648999010453 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 648999010454 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 648999010455 putative active site [active] 648999010456 transaldolase; Provisional; Region: PRK03903 648999010457 catalytic residue [active] 648999010458 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 648999010459 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 648999010460 TPP-binding site [chemical binding]; other site 648999010461 dimer interface [polypeptide binding]; other site 648999010462 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 648999010463 PYR/PP interface [polypeptide binding]; other site 648999010464 dimer interface [polypeptide binding]; other site 648999010465 TPP binding site [chemical binding]; other site 648999010466 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999010467 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 648999010468 UbiA prenyltransferase family; Region: UbiA; pfam01040 648999010469 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999010470 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 648999010471 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 648999010472 CAAX protease self-immunity; Region: Abi; cl00558 648999010473 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 648999010474 Right handed beta helix region; Region: Beta_helix; pfam13229 648999010475 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 648999010476 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 648999010477 Predicted transcriptional regulator [Transcription]; Region: COG2345 648999010478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010479 putative Zn2+ binding site [ion binding]; other site 648999010480 putative DNA binding site [nucleotide binding]; other site 648999010481 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 648999010482 FeS assembly protein SufB; Region: sufB; TIGR01980 648999010483 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 648999010484 FeS assembly protein SufD; Region: sufD; TIGR01981 648999010485 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 648999010486 [2Fe-2S] cluster binding site [ion binding]; other site 648999010487 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 648999010488 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 648999010489 Walker A/P-loop; other site 648999010490 ATP binding site [chemical binding]; other site 648999010491 Q-loop/lid; other site 648999010492 ABC transporter signature motif; other site 648999010493 Walker B; other site 648999010494 D-loop; other site 648999010495 H-loop/switch region; other site 648999010496 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999010497 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 648999010498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999010499 catalytic residue [active] 648999010500 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 648999010501 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 648999010502 trimerization site [polypeptide binding]; other site 648999010503 active site 648999010504 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 648999010505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999010506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999010507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999010508 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999010509 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999010510 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999010511 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999010512 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 648999010513 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 648999010514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999010515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999010516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999010517 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 648999010518 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 648999010519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999010520 substrate binding site [chemical binding]; other site 648999010521 oxyanion hole (OAH) forming residues; other site 648999010522 trimer interface [polypeptide binding]; other site 648999010523 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 648999010524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999010525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999010526 Walker A/P-loop; other site 648999010527 ATP binding site [chemical binding]; other site 648999010528 Q-loop/lid; other site 648999010529 ABC transporter signature motif; other site 648999010530 Walker B; other site 648999010531 D-loop; other site 648999010532 H-loop/switch region; other site 648999010533 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 648999010534 active site 648999010535 SUMO-1 interface [polypeptide binding]; other site 648999010536 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 648999010537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999010538 NAD(P) binding site [chemical binding]; other site 648999010539 active site 648999010540 hypothetical protein; Provisional; Region: PRK05409 648999010541 TIGR04222 domain; Region: near_uncomplex 648999010542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999010543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999010544 Predicted amidohydrolase [General function prediction only]; Region: COG0388 648999010545 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 648999010546 active site 648999010547 catalytic triad [active] 648999010548 dimer interface [polypeptide binding]; other site 648999010549 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 648999010550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999010551 motif II; other site 648999010552 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 648999010553 ATP binding site [chemical binding]; other site 648999010554 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 648999010555 Cytochrome P450; Region: p450; cl12078 648999010556 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999010557 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 648999010558 substrate binding pocket [chemical binding]; other site 648999010559 substrate-Mg2+ binding site; other site 648999010560 aspartate-rich region 1; other site 648999010561 aspartate-rich region 2; other site 648999010562 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 648999010563 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999010564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999010565 ATP binding site [chemical binding]; other site 648999010566 Mg2+ binding site [ion binding]; other site 648999010567 G-X-G motif; other site 648999010568 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 648999010569 Protein of unknown function (DUF742); Region: DUF742; pfam05331 648999010570 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 648999010571 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 648999010572 G1 box; other site 648999010573 GTP/Mg2+ binding site [chemical binding]; other site 648999010574 G2 box; other site 648999010575 Switch I region; other site 648999010576 G3 box; other site 648999010577 Switch II region; other site 648999010578 G4 box; other site 648999010579 G5 box; other site 648999010580 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 648999010581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999010582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 648999010583 dimerization interface [polypeptide binding]; other site 648999010584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999010585 short chain dehydrogenase; Provisional; Region: PRK12937 648999010586 NAD(P) binding site [chemical binding]; other site 648999010587 active site 648999010588 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 648999010589 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999010590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999010591 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999010592 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 648999010593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999010594 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999010595 aconitate hydratase; Validated; Region: PRK09277 648999010596 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 648999010597 substrate binding site [chemical binding]; other site 648999010598 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 648999010599 ligand binding site [chemical binding]; other site 648999010600 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 648999010601 substrate binding site [chemical binding]; other site 648999010602 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 648999010603 dimer interface [polypeptide binding]; other site 648999010604 putative metal binding site [ion binding]; other site 648999010605 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999010606 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999010607 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 648999010608 Amino acid permease; Region: AA_permease; pfam00324 648999010609 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 648999010610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999010611 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999010612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999010613 Coenzyme A binding pocket [chemical binding]; other site 648999010614 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 648999010615 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 648999010616 active site 648999010617 catalytic site [active] 648999010618 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 648999010619 carbohydrate binding site [chemical binding]; other site 648999010620 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 648999010621 carbohydrate binding site [chemical binding]; other site 648999010622 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 648999010623 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 648999010624 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 648999010625 Ca binding site [ion binding]; other site 648999010626 active site 648999010627 catalytic site [active] 648999010628 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 648999010629 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 648999010630 proline aminopeptidase P II; Provisional; Region: PRK10879 648999010631 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 648999010632 active site 648999010633 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 648999010634 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 648999010635 active site 648999010636 dimer interface [polypeptide binding]; other site 648999010637 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 648999010638 Ligand Binding Site [chemical binding]; other site 648999010639 Molecular Tunnel; other site 648999010640 Chitin binding domain; Region: Chitin_bind_3; pfam03067 648999010641 Cellulose binding domain; Region: CBM_2; pfam00553 648999010642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 648999010643 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 648999010644 substrate binding site [chemical binding]; other site 648999010645 ATP binding site [chemical binding]; other site 648999010646 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 648999010647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999010648 MarR family; Region: MarR; pfam01047 648999010649 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999010650 Phosphotransferase enzyme family; Region: APH; pfam01636 648999010651 active site 648999010652 substrate binding site [chemical binding]; other site 648999010653 ATP binding site [chemical binding]; other site 648999010654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999010655 Predicted thioesterase [General function prediction only]; Region: COG5496 648999010656 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 648999010657 active site 648999010658 Predicted membrane protein [Function unknown]; Region: COG3428 648999010659 Bacterial PH domain; Region: DUF304; pfam03703 648999010660 Bacterial PH domain; Region: DUF304; pfam03703 648999010661 Bacterial PH domain; Region: DUF304; pfam03703 648999010662 Bacterial PH domain; Region: DUF304; cl01348 648999010663 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999010664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999010665 Walker A motif; other site 648999010666 ATP binding site [chemical binding]; other site 648999010667 Walker B motif; other site 648999010668 arginine finger; other site 648999010669 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999010670 von Willebrand factor type A domain; Region: VWA_2; pfam13519 648999010671 metal ion-dependent adhesion site (MIDAS); other site 648999010672 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 648999010673 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 648999010674 NAD(P) binding site [chemical binding]; other site 648999010675 homotetramer interface [polypeptide binding]; other site 648999010676 homodimer interface [polypeptide binding]; other site 648999010677 active site 648999010678 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 648999010679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999010680 NAD(P) binding site [chemical binding]; other site 648999010681 active site 648999010682 ferrochelatase; Reviewed; Region: hemH; PRK00035 648999010683 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 648999010684 C-terminal domain interface [polypeptide binding]; other site 648999010685 active site 648999010686 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 648999010687 active site 648999010688 N-terminal domain interface [polypeptide binding]; other site 648999010689 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 648999010690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999010691 active site 648999010692 motif I; other site 648999010693 motif II; other site 648999010694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999010695 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 648999010696 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999010697 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999010698 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 648999010699 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 648999010700 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 648999010701 Transglycosylase; Region: Transgly; pfam00912 648999010702 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 648999010703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999010704 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999010705 active site 648999010706 RibD C-terminal domain; Region: RibD_C; cl17279 648999010707 thiamine pyrophosphate protein; Provisional; Region: PRK08273 648999010708 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 648999010709 PYR/PP interface [polypeptide binding]; other site 648999010710 dimer interface [polypeptide binding]; other site 648999010711 tetramer interface [polypeptide binding]; other site 648999010712 TPP binding site [chemical binding]; other site 648999010713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 648999010714 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 648999010715 TPP-binding site [chemical binding]; other site 648999010716 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 648999010717 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 648999010718 argininosuccinate synthase; Validated; Region: PRK05370 648999010719 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 648999010720 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999010721 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 648999010722 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 648999010723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 648999010724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999010725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999010726 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 648999010727 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999010728 inhibitor-cofactor binding pocket; inhibition site 648999010729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999010730 catalytic residue [active] 648999010731 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 648999010732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999010733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010734 dimer interface [polypeptide binding]; other site 648999010735 conserved gate region; other site 648999010736 putative PBP binding loops; other site 648999010737 ABC-ATPase subunit interface; other site 648999010738 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999010739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010740 dimer interface [polypeptide binding]; other site 648999010741 conserved gate region; other site 648999010742 putative PBP binding loops; other site 648999010743 ABC-ATPase subunit interface; other site 648999010744 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 648999010745 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 648999010746 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 648999010747 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 648999010748 putative active site [active] 648999010749 hypothetical protein; Provisional; Region: PRK02947 648999010750 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 648999010751 putative active site [active] 648999010752 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 648999010753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999010754 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 648999010755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010756 putative PBP binding loops; other site 648999010757 ABC-ATPase subunit interface; other site 648999010758 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010760 dimer interface [polypeptide binding]; other site 648999010761 conserved gate region; other site 648999010762 ABC-ATPase subunit interface; other site 648999010763 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 648999010764 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 648999010765 active site 648999010766 DNA binding site [nucleotide binding] 648999010767 catalytic site [active] 648999010768 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 648999010769 metal-binding site 648999010770 TfoX N-terminal domain; Region: TfoX_N; cl17592 648999010771 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999010772 active site 648999010773 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999010774 active site 648999010775 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 648999010776 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999010777 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 648999010778 phosphate binding site [ion binding]; other site 648999010779 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999010780 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999010781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999010782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010783 dimer interface [polypeptide binding]; other site 648999010784 conserved gate region; other site 648999010785 putative PBP binding loops; other site 648999010786 ABC-ATPase subunit interface; other site 648999010787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010788 dimer interface [polypeptide binding]; other site 648999010789 conserved gate region; other site 648999010790 putative PBP binding loops; other site 648999010791 ABC-ATPase subunit interface; other site 648999010792 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999010793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999010794 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 648999010795 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999010796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999010797 DNA binding site [nucleotide binding] 648999010798 domain linker motif; other site 648999010799 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999010800 dimerization interface [polypeptide binding]; other site 648999010801 ligand binding site [chemical binding]; other site 648999010802 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 648999010803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999010804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999010805 active site 648999010806 ATP binding site [chemical binding]; other site 648999010807 substrate binding site [chemical binding]; other site 648999010808 activation loop (A-loop); other site 648999010809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999010810 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999010811 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 648999010812 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 648999010813 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 648999010814 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 648999010815 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 648999010816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999010817 motif II; other site 648999010818 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 648999010819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999010820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999010821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010822 dimer interface [polypeptide binding]; other site 648999010823 conserved gate region; other site 648999010824 putative PBP binding loops; other site 648999010825 ABC-ATPase subunit interface; other site 648999010826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999010827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999010828 dimer interface [polypeptide binding]; other site 648999010829 conserved gate region; other site 648999010830 putative PBP binding loops; other site 648999010831 ABC-ATPase subunit interface; other site 648999010832 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 648999010833 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 648999010834 Walker A/P-loop; other site 648999010835 ATP binding site [chemical binding]; other site 648999010836 Q-loop/lid; other site 648999010837 ABC transporter signature motif; other site 648999010838 Walker B; other site 648999010839 D-loop; other site 648999010840 H-loop/switch region; other site 648999010841 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 648999010842 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999010843 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 648999010844 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999010845 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 648999010846 Glutamine amidotransferase class-I; Region: GATase; pfam00117 648999010847 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 648999010848 glutamine binding [chemical binding]; other site 648999010849 catalytic triad [active] 648999010850 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 648999010851 D-xylulose kinase; Region: XylB; TIGR01312 648999010852 N- and C-terminal domain interface [polypeptide binding]; other site 648999010853 active site 648999010854 catalytic site [active] 648999010855 metal binding site [ion binding]; metal-binding site 648999010856 carbohydrate binding site [chemical binding]; other site 648999010857 ATP binding site [chemical binding]; other site 648999010858 Nitrate and nitrite sensing; Region: NIT; pfam08376 648999010859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999010860 ATP binding site [chemical binding]; other site 648999010861 Mg2+ binding site [ion binding]; other site 648999010862 G-X-G motif; other site 648999010863 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 648999010864 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999010865 beta-galactosidase; Region: BGL; TIGR03356 648999010866 Cellulose binding domain; Region: CBM_2; pfam00553 648999010867 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 648999010868 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 648999010869 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 648999010870 active site 648999010871 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 648999010872 Uncharacterized conserved protein [Function unknown]; Region: COG3342 648999010873 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 648999010874 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999010875 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 648999010876 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 648999010877 classical (c) SDRs; Region: SDR_c; cd05233 648999010878 NAD(P) binding site [chemical binding]; other site 648999010879 active site 648999010880 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999010881 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 648999010882 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 648999010883 Protein of unknown function DUF58; Region: DUF58; pfam01882 648999010884 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999010885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999010886 Walker A motif; other site 648999010887 ATP binding site [chemical binding]; other site 648999010888 Walker B motif; other site 648999010889 arginine finger; other site 648999010890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999010891 Interdomain contacts; other site 648999010892 Cytokine receptor motif; other site 648999010893 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999010894 Interdomain contacts; other site 648999010895 Cytokine receptor motif; other site 648999010896 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999010897 Interdomain contacts; other site 648999010898 Cytokine receptor motif; other site 648999010899 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999010900 Interdomain contacts; other site 648999010901 Cytokine receptor motif; other site 648999010902 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 648999010903 active site 648999010904 catalytic residues [active] 648999010905 Int/Topo IB signature motif; other site 648999010906 DNA binding site [nucleotide binding] 648999010907 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 648999010908 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 648999010909 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 648999010910 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 648999010911 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 648999010912 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 648999010913 active site 648999010914 catalytic residues [active] 648999010915 LexA repressor; Validated; Region: PRK00215 648999010916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010917 putative DNA binding site [nucleotide binding]; other site 648999010918 putative Zn2+ binding site [ion binding]; other site 648999010919 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 648999010920 Catalytic site [active] 648999010921 AAA domain; Region: AAA_23; pfam13476 648999010922 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 648999010923 putative transposase OrfB; Reviewed; Region: PHA02517 648999010924 HTH-like domain; Region: HTH_21; pfam13276 648999010925 Integrase core domain; Region: rve; pfam00665 648999010926 Integrase core domain; Region: rve_3; pfam13683 648999010927 Transposase; Region: HTH_Tnp_1; pfam01527 648999010928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 648999010929 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 648999010930 Predicted amidohydrolase [General function prediction only]; Region: COG0388 648999010931 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 648999010932 active site 648999010933 catalytic triad [active] 648999010934 dimer interface [polypeptide binding]; other site 648999010935 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 648999010936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999010937 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 648999010938 Walker A/P-loop; other site 648999010939 ATP binding site [chemical binding]; other site 648999010940 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 648999010941 putative active site [active] 648999010942 putative metal-binding site [ion binding]; other site 648999010943 Part of AAA domain; Region: AAA_19; pfam13245 648999010944 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 648999010945 Family description; Region: UvrD_C_2; pfam13538 648999010946 Endodeoxyribonuclease RusA; Region: RusA; cl01885 648999010947 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 648999010948 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999010949 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999010950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999010951 catalytic residue [active] 648999010952 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 648999010953 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 648999010954 active site 648999010955 catalytic residues [active] 648999010956 DNA binding site [nucleotide binding] 648999010957 Int/Topo IB signature motif; other site 648999010958 Family description; Region: DsbD_2; pfam13386 648999010959 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 648999010960 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 648999010961 metal-binding site [ion binding] 648999010962 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 648999010963 MMPL family; Region: MMPL; pfam03176 648999010964 MMPL family; Region: MMPL; pfam03176 648999010965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999010966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999010967 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 648999010968 sequence-specific DNA binding site [nucleotide binding]; other site 648999010969 Helix-turn-helix domain; Region: HTH_18; pfam12833 648999010970 salt bridge; other site 648999010971 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 648999010972 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 648999010973 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 648999010974 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 648999010975 putative active site [active] 648999010976 catalytic triad [active] 648999010977 putative dimer interface [polypeptide binding]; other site 648999010978 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 648999010979 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 648999010980 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 648999010981 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999010982 catalytic residues [active] 648999010983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010984 dimerization interface [polypeptide binding]; other site 648999010985 putative DNA binding site [nucleotide binding]; other site 648999010986 putative Zn2+ binding site [ion binding]; other site 648999010987 ResB-like family; Region: ResB; pfam05140 648999010988 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 648999010989 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 648999010990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999010991 dimerization interface [polypeptide binding]; other site 648999010992 putative DNA binding site [nucleotide binding]; other site 648999010993 putative Zn2+ binding site [ion binding]; other site 648999010994 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 648999010995 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 648999010996 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 648999010997 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 648999010998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999010999 Soluble P-type ATPase [General function prediction only]; Region: COG4087 648999011000 Cation efflux family; Region: Cation_efflux; cl00316 648999011001 Predicted membrane protein [Function unknown]; Region: COG3428 648999011002 mercuric reductase; Region: MerA; TIGR02053 648999011003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999011004 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999011005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999011006 dimerization interface [polypeptide binding]; other site 648999011007 putative DNA binding site [nucleotide binding]; other site 648999011008 putative Zn2+ binding site [ion binding]; other site 648999011009 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 648999011010 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999011011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999011012 active site 648999011013 motif I; other site 648999011014 motif II; other site 648999011015 Domain of unknown function (DUF305); Region: DUF305; cl17794 648999011016 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 648999011017 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 648999011018 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 648999011019 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 648999011020 NADH dehydrogenase; Region: NADHdh; cl00469 648999011021 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 648999011022 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999011023 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 648999011024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999011025 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 648999011026 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999011027 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999011028 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999011029 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 648999011030 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 648999011031 Multicopper oxidase; Region: Cu-oxidase; pfam00394 648999011032 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 648999011033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999011034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011035 active site 648999011036 phosphorylation site [posttranslational modification] 648999011037 intermolecular recognition site; other site 648999011038 dimerization interface [polypeptide binding]; other site 648999011039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999011040 DNA binding site [nucleotide binding] 648999011041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999011042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 648999011043 dimerization interface [polypeptide binding]; other site 648999011044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999011045 dimer interface [polypeptide binding]; other site 648999011046 phosphorylation site [posttranslational modification] 648999011047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999011048 ATP binding site [chemical binding]; other site 648999011049 Mg2+ binding site [ion binding]; other site 648999011050 G-X-G motif; other site 648999011051 Short C-terminal domain; Region: SHOCT; pfam09851 648999011052 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 648999011053 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 648999011054 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999011055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999011056 active site 648999011057 motif II; other site 648999011058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999011059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999011060 Walker A/P-loop; other site 648999011061 ATP binding site [chemical binding]; other site 648999011062 Q-loop/lid; other site 648999011063 ABC transporter signature motif; other site 648999011064 Walker B; other site 648999011065 D-loop; other site 648999011066 H-loop/switch region; other site 648999011067 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 648999011068 Domain of unknown function (DUF305); Region: DUF305; pfam03713 648999011069 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999011070 putative active site [active] 648999011071 Penicillinase repressor; Region: Pencillinase_R; pfam03965 648999011072 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 648999011073 catalytic residues [active] 648999011074 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 648999011075 metal-binding site [ion binding] 648999011076 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 648999011077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999011078 putative substrate translocation pore; other site 648999011079 CopC domain; Region: CopC; pfam04234 648999011080 AAA domain; Region: AAA_11; pfam13086 648999011081 Part of AAA domain; Region: AAA_19; pfam13245 648999011082 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 648999011083 AAA domain; Region: AAA_12; pfam13087 648999011084 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 648999011085 PLD-like domain; Region: PLDc_2; pfam13091 648999011086 putative active site [active] 648999011087 catalytic site [active] 648999011088 DEAD-like helicases superfamily; Region: DEXDc; smart00487 648999011089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999011090 ATP binding site [chemical binding]; other site 648999011091 putative Mg++ binding site [ion binding]; other site 648999011092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999011093 nucleotide binding region [chemical binding]; other site 648999011094 ATP-binding site [chemical binding]; other site 648999011095 Recombinase; Region: Recombinase; pfam07508 648999011096 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 648999011097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 648999011098 helicase superfamily c-terminal domain; Region: HELICc; smart00490 648999011099 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 648999011100 NB-ARC domain; Region: NB-ARC; pfam00931 648999011101 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011103 binding surface 648999011104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011105 TPR motif; other site 648999011106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011107 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011109 binding surface 648999011110 TPR motif; other site 648999011111 Mrr N-terminal domain; Region: Mrr_N; pfam14338 648999011112 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999011113 beta-galactosidase; Region: BGL; TIGR03356 648999011114 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999011115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011116 dimer interface [polypeptide binding]; other site 648999011117 conserved gate region; other site 648999011118 putative PBP binding loops; other site 648999011119 ABC-ATPase subunit interface; other site 648999011120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011121 dimer interface [polypeptide binding]; other site 648999011122 conserved gate region; other site 648999011123 putative PBP binding loops; other site 648999011124 ABC-ATPase subunit interface; other site 648999011125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999011126 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999011127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999011128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999011129 DNA binding site [nucleotide binding] 648999011130 domain linker motif; other site 648999011131 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999011132 ligand binding site [chemical binding]; other site 648999011133 dimerization interface [polypeptide binding]; other site 648999011134 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 648999011135 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 648999011136 active site 648999011137 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 648999011138 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999011139 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999011140 putative sugar binding sites [chemical binding]; other site 648999011141 Q-X-W motif; other site 648999011142 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 648999011143 O-methyltransferase; Region: Methyltransf_2; pfam00891 648999011144 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999011145 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999011146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999011147 catalytic residue [active] 648999011148 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 648999011149 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 648999011150 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999011151 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999011152 Transposase; Region: HTH_Tnp_1; pfam01527 648999011153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011154 Response regulator receiver domain; Region: Response_reg; pfam00072 648999011155 active site 648999011156 phosphorylation site [posttranslational modification] 648999011157 intermolecular recognition site; other site 648999011158 dimerization interface [polypeptide binding]; other site 648999011159 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999011160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999011161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999011162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999011163 ATP binding site [chemical binding]; other site 648999011164 Mg2+ binding site [ion binding]; other site 648999011165 G-X-G motif; other site 648999011166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999011167 Putative esterase; Region: Esterase; pfam00756 648999011168 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 648999011169 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999011170 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999011171 Family description; Region: VCBS; pfam13517 648999011172 Family description; Region: VCBS; pfam13517 648999011173 Family description; Region: VCBS; pfam13517 648999011174 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 648999011175 Family description; Region: VCBS; pfam13517 648999011176 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 648999011177 putative metal binding site [ion binding]; other site 648999011178 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 648999011179 active site 648999011180 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 648999011181 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999011182 Walker A/P-loop; other site 648999011183 ATP binding site [chemical binding]; other site 648999011184 Q-loop/lid; other site 648999011185 ABC transporter signature motif; other site 648999011186 Walker B; other site 648999011187 D-loop; other site 648999011188 H-loop/switch region; other site 648999011189 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 648999011190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999011191 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999011192 TM-ABC transporter signature motif; other site 648999011193 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 648999011194 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 648999011195 putative ligand binding site [chemical binding]; other site 648999011196 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 648999011197 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 648999011198 N- and C-terminal domain interface [polypeptide binding]; other site 648999011199 putative active site [active] 648999011200 MgATP binding site [chemical binding]; other site 648999011201 catalytic site [active] 648999011202 metal binding site [ion binding]; metal-binding site 648999011203 putative xylulose binding site [chemical binding]; other site 648999011204 putative homodimer interface [polypeptide binding]; other site 648999011205 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 648999011206 hexamer (dimer of trimers) interface [polypeptide binding]; other site 648999011207 trimer interface [polypeptide binding]; other site 648999011208 substrate binding site [chemical binding]; other site 648999011209 Mn binding site [ion binding]; other site 648999011210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999011211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999011212 DNA binding site [nucleotide binding] 648999011213 domain linker motif; other site 648999011214 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999011215 ligand binding site [chemical binding]; other site 648999011216 dimerization interface [polypeptide binding]; other site 648999011217 Family description; Region: VCBS; pfam13517 648999011218 FG-GAP repeat; Region: FG-GAP; pfam01839 648999011219 Family description; Region: VCBS; pfam13517 648999011220 Family description; Region: VCBS; pfam13517 648999011221 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 648999011222 amidase catalytic site [active] 648999011223 Zn binding residues [ion binding]; other site 648999011224 substrate binding site [chemical binding]; other site 648999011225 Family description; Region: VCBS; pfam13517 648999011226 Family description; Region: VCBS; pfam13517 648999011227 Family description; Region: VCBS; pfam13517 648999011228 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 648999011229 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 648999011230 putative ligand binding residues [chemical binding]; other site 648999011231 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 648999011232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999011233 dimer interface [polypeptide binding]; other site 648999011234 putative PBP binding regions; other site 648999011235 ABC-ATPase subunit interface; other site 648999011236 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999011237 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 648999011238 Walker A/P-loop; other site 648999011239 ATP binding site [chemical binding]; other site 648999011240 Q-loop/lid; other site 648999011241 ABC transporter signature motif; other site 648999011242 Walker B; other site 648999011243 D-loop; other site 648999011244 H-loop/switch region; other site 648999011245 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999011246 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 648999011247 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 648999011248 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 648999011249 active site 648999011250 SAM binding site [chemical binding]; other site 648999011251 homodimer interface [polypeptide binding]; other site 648999011252 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 648999011253 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999011254 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 648999011255 catalytic triad [active] 648999011256 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 648999011257 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 648999011258 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 648999011259 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 648999011260 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 648999011261 metal ion-dependent adhesion site (MIDAS); other site 648999011262 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 648999011263 active site 648999011264 putative homodimer interface [polypeptide binding]; other site 648999011265 SAM binding site [chemical binding]; other site 648999011266 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 648999011267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011268 S-adenosylmethionine binding site [chemical binding]; other site 648999011269 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 648999011270 active site 648999011271 homodimer interface [polypeptide binding]; other site 648999011272 SAM binding site [chemical binding]; other site 648999011273 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 648999011274 active site 648999011275 SAM binding site [chemical binding]; other site 648999011276 homodimer interface [polypeptide binding]; other site 648999011277 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 648999011278 active site 648999011279 SAM binding site [chemical binding]; other site 648999011280 homodimer interface [polypeptide binding]; other site 648999011281 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 648999011282 Precorrin-8X methylmutase; Region: CbiC; pfam02570 648999011283 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 648999011284 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 648999011285 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 648999011286 dimer interface [polypeptide binding]; other site 648999011287 [2Fe-2S] cluster binding site [ion binding]; other site 648999011288 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 648999011289 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 648999011290 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 648999011291 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 648999011292 active site 648999011293 SAM binding site [chemical binding]; other site 648999011294 homodimer interface [polypeptide binding]; other site 648999011295 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 648999011296 Winged helix-turn helix; Region: HTH_29; pfam13551 648999011297 Integrase core domain; Region: rve; pfam00665 648999011298 Integrase core domain; Region: rve_3; pfam13683 648999011299 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 648999011300 putative metal binding residues [ion binding]; other site 648999011301 signature motif; other site 648999011302 dimer interface [polypeptide binding]; other site 648999011303 active site 648999011304 polyP binding site; other site 648999011305 substrate binding site [chemical binding]; other site 648999011306 acceptor-phosphate pocket; other site 648999011307 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 648999011308 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 648999011309 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 648999011310 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 648999011311 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 648999011312 Major royal jelly protein; Region: MRJP; pfam03022 648999011313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 648999011314 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 648999011315 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 648999011316 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 648999011317 FAD binding pocket [chemical binding]; other site 648999011318 FAD binding motif [chemical binding]; other site 648999011319 phosphate binding motif [ion binding]; other site 648999011320 NAD binding pocket [chemical binding]; other site 648999011321 muropeptide transporter; Validated; Region: ampG; cl17669 648999011322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999011323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999011324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999011325 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 648999011326 IucA / IucC family; Region: IucA_IucC; pfam04183 648999011327 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 648999011328 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 648999011329 IucA / IucC family; Region: IucA_IucC; pfam04183 648999011330 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 648999011331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 648999011332 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 648999011333 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999011334 catalytic residue [active] 648999011335 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999011336 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999011337 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 648999011338 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 648999011339 Clp amino terminal domain; Region: Clp_N; pfam02861 648999011340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999011341 Walker A motif; other site 648999011342 ATP binding site [chemical binding]; other site 648999011343 Walker B motif; other site 648999011344 arginine finger; other site 648999011345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999011346 Walker A motif; other site 648999011347 ATP binding site [chemical binding]; other site 648999011348 Walker B motif; other site 648999011349 arginine finger; other site 648999011350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 648999011351 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 648999011352 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 648999011353 Mechanosensitive ion channel; Region: MS_channel; pfam00924 648999011354 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 648999011355 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 648999011356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999011357 nucleotide binding site [chemical binding]; other site 648999011358 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 648999011359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011360 active site 648999011361 phosphorylation site [posttranslational modification] 648999011362 intermolecular recognition site; other site 648999011363 dimerization interface [polypeptide binding]; other site 648999011364 PAS fold; Region: PAS; pfam00989 648999011365 PAS domain; Region: PAS; smart00091 648999011366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999011367 ATP binding site [chemical binding]; other site 648999011368 Mg2+ binding site [ion binding]; other site 648999011369 G-X-G motif; other site 648999011370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 648999011371 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 648999011372 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 648999011373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999011374 Ligand Binding Site [chemical binding]; other site 648999011375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999011376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999011377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 648999011378 dimerization interface [polypeptide binding]; other site 648999011379 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 648999011380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999011381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011382 active site 648999011383 phosphorylation site [posttranslational modification] 648999011384 intermolecular recognition site; other site 648999011385 dimerization interface [polypeptide binding]; other site 648999011386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999011387 DNA binding site [nucleotide binding] 648999011388 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 648999011389 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 648999011390 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 648999011391 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 648999011392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999011393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999011394 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 648999011395 dimerization interface [polypeptide binding]; other site 648999011396 substrate binding pocket [chemical binding]; other site 648999011397 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 648999011398 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 648999011399 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 648999011400 lipoyl attachment site [posttranslational modification]; other site 648999011401 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 648999011402 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 648999011403 dimer interface [polypeptide binding]; other site 648999011404 active site 648999011405 glycine-pyridoxal phosphate binding site [chemical binding]; other site 648999011406 folate binding site [chemical binding]; other site 648999011407 Proline dehydrogenase; Region: Pro_dh; cl03282 648999011408 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 648999011409 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 648999011410 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 648999011411 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 648999011412 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 648999011413 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 648999011414 hydroxyglutarate oxidase; Provisional; Region: PRK11728 648999011415 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 648999011416 proline aminopeptidase P II; Provisional; Region: PRK10879 648999011417 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 648999011418 active site 648999011419 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 648999011420 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 648999011421 NAD(P) binding site [chemical binding]; other site 648999011422 catalytic residues [active] 648999011423 Proline racemase; Region: Pro_racemase; pfam05544 648999011424 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 648999011425 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 648999011426 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 648999011427 inhibitor site; inhibition site 648999011428 active site 648999011429 dimer interface [polypeptide binding]; other site 648999011430 catalytic residue [active] 648999011431 Transcriptional regulators [Transcription]; Region: GntR; COG1802 648999011432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999011433 DNA-binding site [nucleotide binding]; DNA binding site 648999011434 FCD domain; Region: FCD; pfam07729 648999011435 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 648999011436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 648999011437 TPR motif; other site 648999011438 Fusaric acid resistance protein family; Region: FUSC; pfam04632 648999011439 Protein of unknown function (DUF808); Region: DUF808; cl01002 648999011440 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 648999011441 RibD C-terminal domain; Region: RibD_C; cl17279 648999011442 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 648999011443 S-adenosylmethionine synthetase; Validated; Region: PRK05250 648999011444 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 648999011445 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 648999011446 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 648999011447 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 648999011448 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 648999011449 NAD binding site [chemical binding]; other site 648999011450 substrate binding site [chemical binding]; other site 648999011451 homodimer interface [polypeptide binding]; other site 648999011452 active site 648999011453 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 648999011454 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 648999011455 substrate binding site; other site 648999011456 tetramer interface; other site 648999011457 Putative cyclase; Region: Cyclase; pfam04199 648999011458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 648999011459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011460 NAD(P) binding site [chemical binding]; other site 648999011461 active site 648999011462 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011463 homodimer interface [polypeptide binding]; other site 648999011464 active site 648999011465 TDP-binding site; other site 648999011466 acceptor substrate-binding pocket; other site 648999011467 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 648999011468 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999011469 dimer interface [polypeptide binding]; other site 648999011470 active site 648999011471 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 648999011472 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999011473 active site 648999011474 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999011475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011476 NAD(P) binding site [chemical binding]; other site 648999011477 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 648999011478 active site 648999011479 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 648999011480 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 648999011481 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 648999011482 [2Fe-2S] cluster binding site [ion binding]; other site 648999011483 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999011484 hydrophobic ligand binding site; other site 648999011485 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 648999011486 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999011487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011488 S-adenosylmethionine binding site [chemical binding]; other site 648999011489 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 648999011490 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999011491 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011492 homodimer interface [polypeptide binding]; other site 648999011493 active site 648999011494 TDP-binding site; other site 648999011495 acceptor substrate-binding pocket; other site 648999011496 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 648999011497 putative hydrophobic ligand binding site [chemical binding]; other site 648999011498 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 648999011499 putative hydrophobic ligand binding site [chemical binding]; other site 648999011500 Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945 648999011501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999011502 NAD(P) binding site [chemical binding]; other site 648999011503 homodimer interface [polypeptide binding]; other site 648999011504 substrate binding site [chemical binding]; other site 648999011505 active site 648999011506 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999011507 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011508 homodimer interface [polypeptide binding]; other site 648999011509 active site 648999011510 TDP-binding site; other site 648999011511 acceptor substrate-binding pocket; other site 648999011512 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999011513 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011514 homodimer interface [polypeptide binding]; other site 648999011515 active site 648999011516 TDP-binding site; other site 648999011517 acceptor substrate-binding pocket; other site 648999011518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999011519 Cytochrome P450; Region: p450; cl12078 648999011520 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999011521 extended (e) SDRs; Region: SDR_e; cd08946 648999011522 substrate binding site [chemical binding]; other site 648999011523 active site 648999011524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011525 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 648999011526 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999011527 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011528 homodimer interface [polypeptide binding]; other site 648999011529 active site 648999011530 TDP-binding site; other site 648999011531 acceptor substrate-binding pocket; other site 648999011532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999011533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999011534 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 648999011535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011536 NAD(P) binding site [chemical binding]; other site 648999011537 active site 648999011538 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011539 homodimer interface [polypeptide binding]; other site 648999011540 active site 648999011541 TDP-binding site; other site 648999011542 acceptor substrate-binding pocket; other site 648999011543 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 648999011544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011545 NAD(P) binding site [chemical binding]; other site 648999011546 active site 648999011547 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 648999011548 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 648999011549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011550 S-adenosylmethionine binding site [chemical binding]; other site 648999011551 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 648999011552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011553 NAD(P) binding site [chemical binding]; other site 648999011554 active site 648999011555 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 648999011556 FAD binding domain; Region: FAD_binding_4; pfam01565 648999011557 Berberine and berberine like; Region: BBE; pfam08031 648999011558 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999011559 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999011560 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999011561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999011562 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999011563 Walker A/P-loop; other site 648999011564 ATP binding site [chemical binding]; other site 648999011565 Q-loop/lid; other site 648999011566 ABC transporter signature motif; other site 648999011567 Walker B; other site 648999011568 D-loop; other site 648999011569 H-loop/switch region; other site 648999011570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011572 active site 648999011573 phosphorylation site [posttranslational modification] 648999011574 intermolecular recognition site; other site 648999011575 dimerization interface [polypeptide binding]; other site 648999011576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999011577 DNA binding residues [nucleotide binding] 648999011578 dimerization interface [polypeptide binding]; other site 648999011579 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999011580 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999011581 NTPase; Region: NTPase_1; cl17478 648999011582 AAA domain; Region: AAA_22; pfam13401 648999011583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999011584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999011585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999011586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011587 S-adenosylmethionine binding site [chemical binding]; other site 648999011588 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 648999011589 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 648999011590 inhibitor-cofactor binding pocket; inhibition site 648999011591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999011592 catalytic residue [active] 648999011593 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 648999011594 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 648999011595 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011596 homodimer interface [polypeptide binding]; other site 648999011597 active site 648999011598 TDP-binding site; other site 648999011599 acceptor substrate-binding pocket; other site 648999011600 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 648999011601 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999011602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999011603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011604 S-adenosylmethionine binding site [chemical binding]; other site 648999011605 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 648999011606 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999011607 homodimer interface [polypeptide binding]; other site 648999011608 active site 648999011609 TDP-binding site; other site 648999011610 acceptor substrate-binding pocket; other site 648999011611 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 648999011612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999011613 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 648999011614 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999011615 DNA binding site [nucleotide binding] 648999011616 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999011617 NB-ARC domain; Region: NB-ARC; pfam00931 648999011618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011619 binding surface 648999011620 TPR motif; other site 648999011621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011623 binding surface 648999011624 TPR motif; other site 648999011625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011626 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 648999011627 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 648999011628 Catalytic site [active] 648999011629 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999011630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999011631 Walker A/P-loop; other site 648999011632 ATP binding site [chemical binding]; other site 648999011633 Q-loop/lid; other site 648999011634 ABC transporter signature motif; other site 648999011635 Walker B; other site 648999011636 D-loop; other site 648999011637 H-loop/switch region; other site 648999011638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999011639 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999011640 DNA binding site [nucleotide binding] 648999011641 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999011642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999011643 CopC domain; Region: CopC; pfam04234 648999011644 Penicillinase repressor; Region: Pencillinase_R; pfam03965 648999011645 Domain of unknown function (DUF305); Region: DUF305; pfam03713 648999011646 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 648999011647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999011648 putative substrate translocation pore; other site 648999011649 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 648999011650 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 648999011651 dimer interface [polypeptide binding]; other site 648999011652 putative functional site; other site 648999011653 putative MPT binding site; other site 648999011654 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 648999011655 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 648999011656 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 648999011657 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 648999011658 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 648999011659 [4Fe-4S] binding site [ion binding]; other site 648999011660 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999011661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999011662 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999011663 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 648999011664 molybdopterin cofactor binding site; other site 648999011665 Hemerythrin-like domain; Region: Hr-like; cd12108 648999011666 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 648999011667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999011668 putative DNA binding site [nucleotide binding]; other site 648999011669 dimerization interface [polypeptide binding]; other site 648999011670 Predicted transcriptional regulator [Transcription]; Region: COG2345 648999011671 putative Zn2+ binding site [ion binding]; other site 648999011672 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 648999011673 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 648999011674 YwiC-like protein; Region: YwiC; pfam14256 648999011675 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999011676 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 648999011677 putative NAD(P) binding site [chemical binding]; other site 648999011678 Chitin binding domain; Region: Chitin_bind_3; pfam03067 648999011679 Cellulose binding domain; Region: CBM_2; pfam00553 648999011680 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 648999011681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999011682 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999011683 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 648999011684 active site clefts [active] 648999011685 zinc binding site [ion binding]; other site 648999011686 dimer interface [polypeptide binding]; other site 648999011687 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999011688 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 648999011689 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 648999011690 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 648999011691 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 648999011692 Fatty acid desaturase; Region: FA_desaturase; pfam00487 648999011693 Di-iron ligands [ion binding]; other site 648999011694 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 648999011695 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 648999011696 TPR repeat; Region: TPR_11; pfam13414 648999011697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011698 binding surface 648999011699 TPR motif; other site 648999011700 TPR repeat; Region: TPR_11; pfam13414 648999011701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999011702 binding surface 648999011703 TPR motif; other site 648999011704 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 648999011705 substrate binding pocket [chemical binding]; other site 648999011706 catalytic residues [active] 648999011707 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999011708 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999011709 putative sugar binding sites [chemical binding]; other site 648999011710 Q-X-W motif; other site 648999011711 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 648999011712 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 648999011713 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999011714 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 648999011715 Walker A/P-loop; other site 648999011716 ATP binding site [chemical binding]; other site 648999011717 Q-loop/lid; other site 648999011718 ABC transporter signature motif; other site 648999011719 Walker B; other site 648999011720 D-loop; other site 648999011721 H-loop/switch region; other site 648999011722 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999011723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999011724 Walker A/P-loop; other site 648999011725 ATP binding site [chemical binding]; other site 648999011726 Q-loop/lid; other site 648999011727 ABC transporter signature motif; other site 648999011728 Walker B; other site 648999011729 D-loop; other site 648999011730 H-loop/switch region; other site 648999011731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999011732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999011733 active site 648999011734 phosphorylation site [posttranslational modification] 648999011735 intermolecular recognition site; other site 648999011736 dimerization interface [polypeptide binding]; other site 648999011737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999011738 DNA binding residues [nucleotide binding] 648999011739 dimerization interface [polypeptide binding]; other site 648999011740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 648999011741 Histidine kinase; Region: HisKA_3; pfam07730 648999011742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999011743 ATP binding site [chemical binding]; other site 648999011744 Mg2+ binding site [ion binding]; other site 648999011745 G-X-G motif; other site 648999011746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999011747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999011748 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999011749 Walker A/P-loop; other site 648999011750 ATP binding site [chemical binding]; other site 648999011751 Q-loop/lid; other site 648999011752 ABC transporter signature motif; other site 648999011753 Walker B; other site 648999011754 D-loop; other site 648999011755 H-loop/switch region; other site 648999011756 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 648999011757 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 648999011758 metal binding site [ion binding]; metal-binding site 648999011759 substrate binding pocket [chemical binding]; other site 648999011760 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 648999011761 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 648999011762 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 648999011763 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999011764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999011765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999011766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011767 dimer interface [polypeptide binding]; other site 648999011768 ABC-ATPase subunit interface; other site 648999011769 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 648999011770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011771 dimer interface [polypeptide binding]; other site 648999011772 conserved gate region; other site 648999011773 putative PBP binding loops; other site 648999011774 ABC-ATPase subunit interface; other site 648999011775 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 648999011776 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 648999011777 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 648999011778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011779 NAD(P) binding site [chemical binding]; other site 648999011780 active site 648999011781 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 648999011782 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 648999011783 short chain dehydrogenase; Provisional; Region: PRK06180 648999011784 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 648999011785 NADP binding site [chemical binding]; other site 648999011786 active site 648999011787 steroid binding site; other site 648999011788 Peptidase family M23; Region: Peptidase_M23; pfam01551 648999011789 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 648999011790 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 648999011791 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 648999011792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999011793 acyl-activating enzyme (AAE) consensus motif; other site 648999011794 AMP binding site [chemical binding]; other site 648999011795 active site 648999011796 CoA binding site [chemical binding]; other site 648999011797 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 648999011798 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 648999011799 dimer interface [polypeptide binding]; other site 648999011800 active site 648999011801 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 648999011802 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 648999011803 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 648999011804 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 648999011805 ligand binding site [chemical binding]; other site 648999011806 flexible hinge region; other site 648999011807 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 648999011808 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 648999011809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999011810 phosphate binding site [ion binding]; other site 648999011811 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 648999011812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999011813 substrate binding site [chemical binding]; other site 648999011814 oxyanion hole (OAH) forming residues; other site 648999011815 trimer interface [polypeptide binding]; other site 648999011816 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011817 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011818 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011819 active site 648999011820 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 648999011821 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999011822 putative NADP binding site [chemical binding]; other site 648999011823 active site 648999011824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011825 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011826 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011827 active site 648999011828 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999011829 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999011830 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 648999011831 KR domain; Region: KR; pfam08659 648999011832 putative NADP binding site [chemical binding]; other site 648999011833 active site 648999011834 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011836 active site 648999011837 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 648999011838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999011839 substrate binding site [chemical binding]; other site 648999011840 oxyanion hole (OAH) forming residues; other site 648999011841 trimer interface [polypeptide binding]; other site 648999011842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011843 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011844 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011845 active site 648999011846 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999011847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999011848 NAD(P) binding site [chemical binding]; other site 648999011849 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999011850 active site 648999011851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011852 S-adenosylmethionine binding site [chemical binding]; other site 648999011853 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999011854 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011855 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011856 active site 648999011857 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 648999011858 putative NADP binding site [chemical binding]; other site 648999011859 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999011860 active site 648999011861 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011862 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011863 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011864 active site 648999011865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011866 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999011867 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 648999011868 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999011869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999011870 catalytic residue [active] 648999011871 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 648999011872 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 648999011873 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999011874 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 648999011875 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 648999011876 dimer interface [polypeptide binding]; other site 648999011877 active site 648999011878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999011879 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999011880 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999011881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999011882 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999011883 Walker A/P-loop; other site 648999011884 ATP binding site [chemical binding]; other site 648999011885 Q-loop/lid; other site 648999011886 ABC transporter signature motif; other site 648999011887 Walker B; other site 648999011888 D-loop; other site 648999011889 H-loop/switch region; other site 648999011890 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999011891 Cytochrome P450; Region: p450; cl12078 648999011892 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 648999011893 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 648999011894 inhibitor-cofactor binding pocket; inhibition site 648999011895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999011896 catalytic residue [active] 648999011897 Thioesterase domain; Region: Thioesterase; pfam00975 648999011898 Condensation domain; Region: Condensation; pfam00668 648999011899 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999011900 Nonribosomal peptide synthase; Region: NRPS; pfam08415 648999011901 Condensation domain; Region: Condensation; pfam00668 648999011902 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 648999011903 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999011904 acyl-activating enzyme (AAE) consensus motif; other site 648999011905 AMP binding site [chemical binding]; other site 648999011906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011907 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 648999011908 NADPH bind site [chemical binding]; other site 648999011909 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999011910 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999011911 active site 648999011912 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 648999011913 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999011914 PfaD family protein; Region: pfaD_fam; TIGR02814 648999011915 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999011916 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999011917 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999011918 acyl-activating enzyme (AAE) consensus motif; other site 648999011919 AMP binding site [chemical binding]; other site 648999011920 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999011921 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 648999011922 acyl carrier protein; Validated; Region: PRK07117 648999011923 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 648999011924 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999011925 active site 648999011926 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 648999011927 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999011928 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 648999011929 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999011930 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999011931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011932 ABC-ATPase subunit interface; other site 648999011933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999011934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999011935 putative PBP binding loops; other site 648999011936 dimer interface [polypeptide binding]; other site 648999011937 ABC-ATPase subunit interface; other site 648999011938 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 648999011939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999011940 Walker A/P-loop; other site 648999011941 ATP binding site [chemical binding]; other site 648999011942 Q-loop/lid; other site 648999011943 ABC transporter signature motif; other site 648999011944 Walker B; other site 648999011945 D-loop; other site 648999011946 H-loop/switch region; other site 648999011947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999011948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999011949 Walker A/P-loop; other site 648999011950 ATP binding site [chemical binding]; other site 648999011951 Q-loop/lid; other site 648999011952 ABC transporter signature motif; other site 648999011953 Walker B; other site 648999011954 D-loop; other site 648999011955 H-loop/switch region; other site 648999011956 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999011957 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 648999011958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999011959 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999011960 active site 648999011961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999011962 S-adenosylmethionine binding site [chemical binding]; other site 648999011963 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 648999011964 B12 binding site [chemical binding]; other site 648999011965 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 648999011966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999011967 FeS/SAM binding site; other site 648999011968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 648999011969 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999011970 Predicted ATPase [General function prediction only]; Region: COG3899 648999011971 AAA ATPase domain; Region: AAA_16; pfam13191 648999011972 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 648999011973 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999011974 Family description; Region: VCBS; pfam13517 648999011975 Family description; Region: VCBS; pfam13517 648999011976 Family description; Region: VCBS; pfam13517 648999011977 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 648999011978 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 648999011979 dimer interface [polypeptide binding]; other site 648999011980 active site 648999011981 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999011982 catalytic residues [active] 648999011983 substrate binding site [chemical binding]; other site 648999011984 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 648999011985 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999011986 active site 648999011987 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 648999011988 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 648999011989 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999011990 acyl-activating enzyme (AAE) consensus motif; other site 648999011991 AMP binding site [chemical binding]; other site 648999011992 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999011993 active site 648999011994 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 648999011995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999011996 acyl-activating enzyme (AAE) consensus motif; other site 648999011997 AMP binding site [chemical binding]; other site 648999011998 active site 648999011999 CoA binding site [chemical binding]; other site 648999012000 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 648999012001 MatE; Region: MatE; pfam01554 648999012002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999012003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999012004 active site 648999012005 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999012006 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 648999012007 active site 648999012008 catalytic residues [active] 648999012009 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 648999012010 RHS Repeat; Region: RHS_repeat; cl11982 648999012011 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 648999012012 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999012013 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999012014 RHS Repeat; Region: RHS_repeat; pfam05593 648999012015 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 648999012016 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 648999012017 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999012018 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999012019 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999012020 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 648999012021 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 648999012022 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 648999012023 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 648999012024 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 648999012025 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999012026 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 648999012027 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999012028 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999012029 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 648999012030 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 648999012031 Protein of unknown function (DUF690); Region: DUF690; cl04939 648999012032 Right handed beta helix region; Region: Beta_helix; pfam13229 648999012033 Right handed beta helix region; Region: Beta_helix; pfam13229 648999012034 Right handed beta helix region; Region: Beta_helix; pfam13229 648999012035 Right handed beta helix region; Region: Beta_helix; pfam13229 648999012036 stage V sporulation protein K; Region: spore_V_K; TIGR02881 648999012037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999012038 Walker A motif; other site 648999012039 ATP binding site [chemical binding]; other site 648999012040 Walker B motif; other site 648999012041 arginine finger; other site 648999012042 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 648999012043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 648999012044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999012045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999012046 DNA binding residues [nucleotide binding] 648999012047 dimerization interface [polypeptide binding]; other site 648999012048 DNA binding site [nucleotide binding] 648999012049 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999012050 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999012051 AAA ATPase domain; Region: AAA_16; pfam13191 648999012052 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 648999012053 DNA binding site [nucleotide binding] 648999012054 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999012055 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999012056 CBD_II domain; Region: CBD_II; smart00637 648999012057 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999012058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999012059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012060 ABC-ATPase subunit interface; other site 648999012061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999012062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012063 dimer interface [polypeptide binding]; other site 648999012064 conserved gate region; other site 648999012065 putative PBP binding loops; other site 648999012066 ABC-ATPase subunit interface; other site 648999012067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 648999012068 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 648999012069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999012070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999012071 DNA binding site [nucleotide binding] 648999012072 domain linker motif; other site 648999012073 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 648999012074 ligand binding site [chemical binding]; other site 648999012075 dimerization interface (open form) [polypeptide binding]; other site 648999012076 dimerization interface (closed form) [polypeptide binding]; other site 648999012077 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999012078 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012079 putative sugar binding sites [chemical binding]; other site 648999012080 Q-X-W motif; other site 648999012081 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 648999012082 active site 648999012083 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999012084 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 648999012085 Ca binding site [ion binding]; other site 648999012086 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999012087 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999012088 DNA binding site [nucleotide binding] 648999012089 domain linker motif; other site 648999012090 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999012091 dimerization interface [polypeptide binding]; other site 648999012092 ligand binding site [chemical binding]; other site 648999012093 Cellulose binding domain; Region: CBM_2; pfam00553 648999012094 Cellulose binding domain; Region: CBM_2; pfam00553 648999012095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999012096 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 648999012097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999012098 active site 648999012099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012100 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 648999012101 Walker A/P-loop; other site 648999012102 ATP binding site [chemical binding]; other site 648999012103 Q-loop/lid; other site 648999012104 ABC transporter signature motif; other site 648999012105 Walker B; other site 648999012106 D-loop; other site 648999012107 H-loop/switch region; other site 648999012108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999012109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999012111 Walker A/P-loop; other site 648999012112 ATP binding site [chemical binding]; other site 648999012113 Q-loop/lid; other site 648999012114 ABC transporter signature motif; other site 648999012115 Walker B; other site 648999012116 D-loop; other site 648999012117 H-loop/switch region; other site 648999012118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999012119 active site 648999012120 nucleotide binding site [chemical binding]; other site 648999012121 HIGH motif; other site 648999012122 KMSKS motif; other site 648999012123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999012124 S-adenosylmethionine binding site [chemical binding]; other site 648999012125 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 648999012126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999012127 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 648999012128 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 648999012129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999012130 active site 648999012131 KMSKS motif; other site 648999012132 Cupin domain; Region: Cupin_2; pfam07883 648999012133 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999012134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999012135 non-specific DNA binding site [nucleotide binding]; other site 648999012136 salt bridge; other site 648999012137 sequence-specific DNA binding site [nucleotide binding]; other site 648999012138 AAA ATPase domain; Region: AAA_16; pfam13191 648999012139 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 648999012140 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999012141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999012142 DNA-binding site [nucleotide binding]; DNA binding site 648999012143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999012144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999012145 homodimer interface [polypeptide binding]; other site 648999012146 catalytic residue [active] 648999012147 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 648999012148 FAD binding domain; Region: FAD_binding_4; pfam01565 648999012149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999012150 dimerization interface [polypeptide binding]; other site 648999012151 putative DNA binding site [nucleotide binding]; other site 648999012152 putative Zn2+ binding site [ion binding]; other site 648999012153 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 648999012154 Low molecular weight phosphatase family; Region: LMWPc; cd00115 648999012155 active site 648999012156 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 648999012157 arsenical-resistance protein; Region: acr3; TIGR00832 648999012158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999012159 putative DNA binding site [nucleotide binding]; other site 648999012160 dimerization interface [polypeptide binding]; other site 648999012161 putative Zn2+ binding site [ion binding]; other site 648999012162 Low molecular weight phosphatase family; Region: LMWPc; cl00105 648999012163 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 648999012164 active site 648999012165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999012166 dimerization interface [polypeptide binding]; other site 648999012167 putative DNA binding site [nucleotide binding]; other site 648999012168 putative Zn2+ binding site [ion binding]; other site 648999012169 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 648999012170 VanZ like family; Region: VanZ; pfam04892 648999012171 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 648999012172 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 648999012173 putative ligand binding site [chemical binding]; other site 648999012174 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 648999012175 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999012176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999012177 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999012178 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 648999012179 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 648999012180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012181 Walker A/P-loop; other site 648999012182 ATP binding site [chemical binding]; other site 648999012183 Q-loop/lid; other site 648999012184 ABC transporter signature motif; other site 648999012185 Walker B; other site 648999012186 D-loop; other site 648999012187 H-loop/switch region; other site 648999012188 TOBE domain; Region: TOBE_2; pfam08402 648999012189 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 648999012190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012191 dimer interface [polypeptide binding]; other site 648999012192 conserved gate region; other site 648999012193 putative PBP binding loops; other site 648999012194 ABC-ATPase subunit interface; other site 648999012195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012196 dimer interface [polypeptide binding]; other site 648999012197 conserved gate region; other site 648999012198 putative PBP binding loops; other site 648999012199 ABC-ATPase subunit interface; other site 648999012200 Creatinine amidohydrolase; Region: Creatininase; pfam02633 648999012201 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 648999012202 tetramer interface [polypeptide binding]; other site 648999012203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999012204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999012205 nucleotide binding site [chemical binding]; other site 648999012206 enoyl-CoA hydratase; Provisional; Region: PRK05870 648999012207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 648999012208 substrate binding site [chemical binding]; other site 648999012209 oxyanion hole (OAH) forming residues; other site 648999012210 trimer interface [polypeptide binding]; other site 648999012211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999012212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999012213 active site 648999012214 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 648999012215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999012216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999012217 Coenzyme A transferase; Region: CoA_trans; cl17247 648999012218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999012219 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999012220 NAD(P) binding site [chemical binding]; other site 648999012221 active site 648999012222 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 648999012223 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 648999012224 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999012225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 648999012226 putative acyltransferase; Provisional; Region: PRK05790 648999012227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999012228 dimer interface [polypeptide binding]; other site 648999012229 active site 648999012230 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 648999012231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999012232 acyl-activating enzyme (AAE) consensus motif; other site 648999012233 AMP binding site [chemical binding]; other site 648999012234 active site 648999012235 CoA binding site [chemical binding]; other site 648999012236 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 648999012237 active site 648999012238 metal binding site [ion binding]; metal-binding site 648999012239 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 648999012240 CoA-transferase family III; Region: CoA_transf_3; pfam02515 648999012241 short chain dehydrogenase; Provisional; Region: PRK06523 648999012242 classical (c) SDRs; Region: SDR_c; cd05233 648999012243 NAD(P) binding site [chemical binding]; other site 648999012244 active site 648999012245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999012246 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 648999012247 DNA-binding site [nucleotide binding]; DNA binding site 648999012248 FCD domain; Region: FCD; pfam07729 648999012249 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 648999012250 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 648999012251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999012252 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999012253 active site 648999012254 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 648999012255 Putative cyclase; Region: Cyclase; pfam04199 648999012256 Putative cyclase; Region: Cyclase; cl00814 648999012257 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 648999012258 CoA-transferase family III; Region: CoA_transf_3; pfam02515 648999012259 Transcriptional regulator [Transcription]; Region: IclR; COG1414 648999012260 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 648999012261 Bacterial transcriptional regulator; Region: IclR; pfam01614 648999012262 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 648999012263 EamA-like transporter family; Region: EamA; pfam00892 648999012264 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 648999012265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999012266 hypothetical protein; Provisional; Region: PRK06446 648999012267 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 648999012268 metal binding site [ion binding]; metal-binding site 648999012269 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 648999012270 classical (c) SDRs; Region: SDR_c; cd05233 648999012271 NAD(P) binding site [chemical binding]; other site 648999012272 active site 648999012273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 648999012274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012275 dimer interface [polypeptide binding]; other site 648999012276 conserved gate region; other site 648999012277 putative PBP binding loops; other site 648999012278 ABC-ATPase subunit interface; other site 648999012279 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 648999012280 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 648999012281 Walker A/P-loop; other site 648999012282 ATP binding site [chemical binding]; other site 648999012283 Q-loop/lid; other site 648999012284 ABC transporter signature motif; other site 648999012285 Walker B; other site 648999012286 D-loop; other site 648999012287 H-loop/switch region; other site 648999012288 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999012289 NMT1/THI5 like; Region: NMT1; pfam09084 648999012290 substrate binding pocket [chemical binding]; other site 648999012291 membrane-bound complex binding site; other site 648999012292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999012293 S-adenosylmethionine binding site [chemical binding]; other site 648999012294 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 648999012295 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999012296 phosphate binding site [ion binding]; other site 648999012297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999012298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999012299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999012300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999012301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999012302 Walker A/P-loop; other site 648999012303 ATP binding site [chemical binding]; other site 648999012304 Q-loop/lid; other site 648999012305 ABC transporter signature motif; other site 648999012306 Walker B; other site 648999012307 D-loop; other site 648999012308 H-loop/switch region; other site 648999012309 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999012310 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 648999012311 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 648999012312 putative hydrophobic ligand binding site [chemical binding]; other site 648999012313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999012314 dimerization interface [polypeptide binding]; other site 648999012315 putative DNA binding site [nucleotide binding]; other site 648999012316 putative Zn2+ binding site [ion binding]; other site 648999012317 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 648999012318 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999012319 CBD_II domain; Region: CBD_II; smart00637 648999012320 PaaX-like protein; Region: PaaX; pfam07848 648999012321 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 648999012322 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999012323 Cytochrome P450; Region: p450; cl12078 648999012324 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999012325 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 648999012326 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999012327 dimer interface [polypeptide binding]; other site 648999012328 active site 648999012329 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 648999012330 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999012331 active site 648999012332 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 648999012333 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 648999012334 Condensation domain; Region: Condensation; pfam00668 648999012335 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999012336 Cytochrome P450; Region: p450; cl12078 648999012337 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999012338 active site 648999012339 TDP-binding site; other site 648999012340 acceptor substrate-binding pocket; other site 648999012341 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999012342 Cytochrome P450; Region: p450; cl12078 648999012343 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 648999012344 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 648999012345 active site 648999012346 iron coordination sites [ion binding]; other site 648999012347 substrate binding pocket [chemical binding]; other site 648999012348 O-methyltransferase; Region: Methyltransf_2; pfam00891 648999012349 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999012350 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999012351 substrate binding pocket [chemical binding]; other site 648999012352 chain length determination region; other site 648999012353 substrate-Mg2+ binding site; other site 648999012354 catalytic residues [active] 648999012355 aspartate-rich region 1; other site 648999012356 active site lid residues [active] 648999012357 aspartate-rich region 2; other site 648999012358 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 648999012359 UbiA prenyltransferase family; Region: UbiA; pfam01040 648999012360 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 648999012361 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 648999012362 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 648999012363 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 648999012364 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 648999012365 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999012366 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 648999012367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999012368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999012369 homodimer interface [polypeptide binding]; other site 648999012370 catalytic residue [active] 648999012371 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 648999012372 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 648999012373 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999012374 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999012375 active site 648999012376 TDP-binding site; other site 648999012377 acceptor substrate-binding pocket; other site 648999012378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012379 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999012380 Walker A/P-loop; other site 648999012381 ATP binding site [chemical binding]; other site 648999012382 Q-loop/lid; other site 648999012383 ABC transporter signature motif; other site 648999012384 Walker B; other site 648999012385 D-loop; other site 648999012386 H-loop/switch region; other site 648999012387 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 648999012388 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999012389 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999012390 AMP-binding enzyme; Region: AMP-binding; pfam00501 648999012391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999012392 acyl-activating enzyme (AAE) consensus motif; other site 648999012393 active site 648999012394 AMP binding site [chemical binding]; other site 648999012395 CoA binding site [chemical binding]; other site 648999012396 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 648999012397 N-acetyl-D-glucosamine binding site [chemical binding]; other site 648999012398 catalytic residue [active] 648999012399 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 648999012400 N-acetyl-D-glucosamine binding site [chemical binding]; other site 648999012401 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012402 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999012403 putative sugar binding sites [chemical binding]; other site 648999012404 Q-X-W motif; other site 648999012405 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 648999012406 Cellulose binding domain; Region: CBM_2; cl17741 648999012407 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 648999012408 metal binding site 2 [ion binding]; metal-binding site 648999012409 putative DNA binding helix; other site 648999012410 metal binding site 1 [ion binding]; metal-binding site 648999012411 dimer interface [polypeptide binding]; other site 648999012412 structural Zn2+ binding site [ion binding]; other site 648999012413 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 648999012414 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 648999012415 dimer interface [polypeptide binding]; other site 648999012416 active site 648999012417 heme binding site [chemical binding]; other site 648999012418 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 648999012419 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 648999012420 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 648999012421 active site 648999012422 Ca binding site [ion binding]; other site 648999012423 catalytic site [active] 648999012424 Aamy_C domain; Region: Aamy_C; smart00632 648999012425 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 648999012426 starch-binding site 2 [chemical binding]; other site 648999012427 starch-binding site 1 [chemical binding]; other site 648999012428 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 648999012429 starch-binding site 2 [chemical binding]; other site 648999012430 starch-binding site 1 [chemical binding]; other site 648999012431 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999012432 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012433 putative sugar binding sites [chemical binding]; other site 648999012434 Q-X-W motif; other site 648999012435 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012436 putative sugar binding sites [chemical binding]; other site 648999012437 Q-X-W motif; other site 648999012438 AAA ATPase domain; Region: AAA_16; pfam13191 648999012439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999012440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999012441 DNA binding residues [nucleotide binding] 648999012442 dimerization interface [polypeptide binding]; other site 648999012443 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999012444 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 648999012445 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 648999012446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999012447 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 648999012448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999012449 motif II; other site 648999012450 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 648999012451 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999012452 Ligand Binding Site [chemical binding]; other site 648999012453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999012454 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999012455 anti sigma factor interaction site; other site 648999012456 regulatory phosphorylation site [posttranslational modification]; other site 648999012457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999012458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999012459 dimer interface [polypeptide binding]; other site 648999012460 phosphorylation site [posttranslational modification] 648999012461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999012462 ATP binding site [chemical binding]; other site 648999012463 Mg2+ binding site [ion binding]; other site 648999012464 G-X-G motif; other site 648999012465 Response regulator receiver domain; Region: Response_reg; pfam00072 648999012466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999012467 active site 648999012468 phosphorylation site [posttranslational modification] 648999012469 intermolecular recognition site; other site 648999012470 dimerization interface [polypeptide binding]; other site 648999012471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 648999012472 PAS domain; Region: PAS_9; pfam13426 648999012473 putative active site [active] 648999012474 heme pocket [chemical binding]; other site 648999012475 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 648999012476 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999012477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 648999012478 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999012479 phosphoenolpyruvate synthase; Validated; Region: PRK06241 648999012480 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 648999012481 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 648999012482 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999012483 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999012484 DNA binding residues [nucleotide binding] 648999012485 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 648999012486 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 648999012487 phosphate binding site [ion binding]; other site 648999012488 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 648999012489 Cellulose binding domain; Region: CBM_2; pfam00553 648999012490 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 648999012491 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 648999012492 putative ligand binding site [chemical binding]; other site 648999012493 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 648999012494 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999012495 Walker A/P-loop; other site 648999012496 ATP binding site [chemical binding]; other site 648999012497 Q-loop/lid; other site 648999012498 ABC transporter signature motif; other site 648999012499 Walker B; other site 648999012500 D-loop; other site 648999012501 H-loop/switch region; other site 648999012502 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 648999012503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999012504 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999012505 TM-ABC transporter signature motif; other site 648999012506 alpha-galactosidase; Region: PLN02808; cl17638 648999012507 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012508 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999012509 putative sugar binding sites [chemical binding]; other site 648999012510 Q-X-W motif; other site 648999012511 ribulokinase; Provisional; Region: PRK04123 648999012512 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 648999012513 N- and C-terminal domain interface [polypeptide binding]; other site 648999012514 active site 648999012515 MgATP binding site [chemical binding]; other site 648999012516 catalytic site [active] 648999012517 metal binding site [ion binding]; metal-binding site 648999012518 carbohydrate binding site [chemical binding]; other site 648999012519 homodimer interface [polypeptide binding]; other site 648999012520 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 648999012521 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 648999012522 intersubunit interface [polypeptide binding]; other site 648999012523 active site 648999012524 Zn2+ binding site [ion binding]; other site 648999012525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 648999012526 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 648999012527 putative ligand binding site [chemical binding]; other site 648999012528 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 648999012529 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 648999012530 Walker A/P-loop; other site 648999012531 ATP binding site [chemical binding]; other site 648999012532 Q-loop/lid; other site 648999012533 ABC transporter signature motif; other site 648999012534 Walker B; other site 648999012535 D-loop; other site 648999012536 H-loop/switch region; other site 648999012537 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 648999012538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999012539 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999012540 TM-ABC transporter signature motif; other site 648999012541 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 648999012542 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 648999012543 TM-ABC transporter signature motif; other site 648999012544 L-arabinose isomerase; Provisional; Region: PRK02929 648999012545 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 648999012546 hexamer (dimer of trimers) interface [polypeptide binding]; other site 648999012547 trimer interface [polypeptide binding]; other site 648999012548 substrate binding site [chemical binding]; other site 648999012549 Mn binding site [ion binding]; other site 648999012550 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999012551 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999012552 putative sugar binding sites [chemical binding]; other site 648999012553 Q-X-W motif; other site 648999012554 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 648999012555 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 648999012556 active site 648999012557 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 648999012558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999012559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999012560 DNA binding site [nucleotide binding] 648999012561 domain linker motif; other site 648999012562 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 648999012563 ligand binding site [chemical binding]; other site 648999012564 dimerization interface (open form) [polypeptide binding]; other site 648999012565 dimerization interface (closed form) [polypeptide binding]; other site 648999012566 CopC domain; Region: CopC; pfam04234 648999012567 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 648999012568 Protein of unknown function (DUF461); Region: DUF461; pfam04314 648999012569 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 648999012570 metal binding site 2 [ion binding]; metal-binding site 648999012571 putative DNA binding helix; other site 648999012572 metal binding site 1 [ion binding]; metal-binding site 648999012573 dimer interface [polypeptide binding]; other site 648999012574 structural Zn2+ binding site [ion binding]; other site 648999012575 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 648999012576 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999012577 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999012578 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 648999012579 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 648999012580 carboxyltransferase (CT) interaction site; other site 648999012581 biotinylation site [posttranslational modification]; other site 648999012582 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 648999012583 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 648999012584 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 648999012585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999012586 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999012587 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999012588 active site residue [active] 648999012589 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999012590 active site residue [active] 648999012591 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999012592 active site residue [active] 648999012593 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999012594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999012595 S-adenosylmethionine binding site [chemical binding]; other site 648999012596 sugar efflux transporter; Region: 2A0120; TIGR00899 648999012597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999012598 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 648999012599 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 648999012600 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 648999012601 Walker A/P-loop; other site 648999012602 ATP binding site [chemical binding]; other site 648999012603 Q-loop/lid; other site 648999012604 ABC transporter signature motif; other site 648999012605 Walker B; other site 648999012606 D-loop; other site 648999012607 H-loop/switch region; other site 648999012608 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 648999012609 heme binding pocket [chemical binding]; other site 648999012610 heme ligand [chemical binding]; other site 648999012611 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 648999012612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999012613 ABC-ATPase subunit interface; other site 648999012614 dimer interface [polypeptide binding]; other site 648999012615 putative PBP binding regions; other site 648999012616 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 648999012617 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 648999012618 intersubunit interface [polypeptide binding]; other site 648999012619 Htaa; Region: HtaA; pfam04213 648999012620 WxL domain surface cell wall-binding; Region: WxL; pfam13731 648999012621 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 648999012622 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 648999012623 active site 648999012624 FMN binding site [chemical binding]; other site 648999012625 substrate binding site [chemical binding]; other site 648999012626 3Fe-4S cluster binding site [ion binding]; other site 648999012627 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999012628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999012629 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 648999012630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999012631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999012632 DNA binding site [nucleotide binding] 648999012633 domain linker motif; other site 648999012634 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999012635 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999012636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999012637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012638 dimer interface [polypeptide binding]; other site 648999012639 conserved gate region; other site 648999012640 putative PBP binding loops; other site 648999012641 ABC-ATPase subunit interface; other site 648999012642 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999012643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012644 dimer interface [polypeptide binding]; other site 648999012645 conserved gate region; other site 648999012646 ABC-ATPase subunit interface; other site 648999012647 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 648999012648 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 648999012649 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 648999012650 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 648999012651 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999012652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999012653 active site 648999012654 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 648999012655 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 648999012656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 648999012657 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 648999012658 Probable transposase; Region: OrfB_IS605; pfam01385 648999012659 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 648999012660 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 648999012661 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999012662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999012663 catalytic residue [active] 648999012664 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999012665 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999012666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999012667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999012668 DNA binding residues [nucleotide binding] 648999012669 dimerization interface [polypeptide binding]; other site 648999012670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999012671 S-adenosylmethionine binding site [chemical binding]; other site 648999012672 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999012673 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999012674 hypothetical protein; Provisional; Region: PRK06184 648999012675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999012676 hypothetical protein; Provisional; Region: PRK07236 648999012677 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999012678 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 648999012679 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999012680 Cytochrome P450; Region: p450; cl12078 648999012681 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 648999012682 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 648999012683 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 648999012684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999012685 Right handed beta helix region; Region: Beta_helix; pfam13229 648999012686 Cellulose binding domain; Region: CBM_2; pfam00553 648999012687 putative pectinesterase; Region: PLN02432; cl01911 648999012688 Pectinesterase; Region: Pectinesterase; pfam01095 648999012689 Cellulose binding domain; Region: CBM_2; pfam00553 648999012690 Pectate lyase; Region: Pec_lyase_C; cl01593 648999012691 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 648999012692 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 648999012693 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 648999012694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999012695 motif II; other site 648999012696 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 648999012697 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999012698 DNA binding residues [nucleotide binding] 648999012699 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 648999012700 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 648999012701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 648999012702 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 648999012703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012704 dimer interface [polypeptide binding]; other site 648999012705 conserved gate region; other site 648999012706 putative PBP binding loops; other site 648999012707 ABC-ATPase subunit interface; other site 648999012708 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 648999012709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012710 Walker A/P-loop; other site 648999012711 ATP binding site [chemical binding]; other site 648999012712 Q-loop/lid; other site 648999012713 ABC transporter signature motif; other site 648999012714 Walker B; other site 648999012715 D-loop; other site 648999012716 H-loop/switch region; other site 648999012717 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999012718 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 648999012719 putative NAD(P) binding site [chemical binding]; other site 648999012720 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 648999012721 active site 648999012722 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999012723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999012724 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 648999012725 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 648999012726 dimerization interface [polypeptide binding]; other site 648999012727 active site 648999012728 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 648999012729 RibD C-terminal domain; Region: RibD_C; cl17279 648999012730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999012731 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 648999012732 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 648999012733 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999012734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012735 ABC-ATPase subunit interface; other site 648999012736 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 648999012737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 648999012738 Walker A/P-loop; other site 648999012739 ATP binding site [chemical binding]; other site 648999012740 Q-loop/lid; other site 648999012741 ABC transporter signature motif; other site 648999012742 Walker B; other site 648999012743 D-loop; other site 648999012744 H-loop/switch region; other site 648999012745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012746 dimer interface [polypeptide binding]; other site 648999012747 conserved gate region; other site 648999012748 putative PBP binding loops; other site 648999012749 ABC-ATPase subunit interface; other site 648999012750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 648999012751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999012752 substrate binding pocket [chemical binding]; other site 648999012753 membrane-bound complex binding site; other site 648999012754 hinge residues; other site 648999012755 hypothetical protein; Provisional; Region: PRK07208 648999012756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999012757 SWIM zinc finger; Region: SWIM; pfam04434 648999012758 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999012759 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999012760 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 648999012761 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 648999012762 active site 648999012763 dimer interface [polypeptide binding]; other site 648999012764 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 648999012765 dimer interface [polypeptide binding]; other site 648999012766 active site 648999012767 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999012768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012769 Walker A/P-loop; other site 648999012770 ATP binding site [chemical binding]; other site 648999012771 Q-loop/lid; other site 648999012772 ABC transporter signature motif; other site 648999012773 Walker B; other site 648999012774 D-loop; other site 648999012775 H-loop/switch region; other site 648999012776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999012777 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999012778 active site 648999012779 catalytic tetrad [active] 648999012780 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 648999012781 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 648999012782 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 648999012783 Moco binding site; other site 648999012784 metal coordination site [ion binding]; other site 648999012785 dimerization interface [polypeptide binding]; other site 648999012786 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 648999012787 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 648999012788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012789 Walker A/P-loop; other site 648999012790 ATP binding site [chemical binding]; other site 648999012791 Q-loop/lid; other site 648999012792 ABC transporter signature motif; other site 648999012793 Walker B; other site 648999012794 D-loop; other site 648999012795 H-loop/switch region; other site 648999012796 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 648999012797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012798 dimer interface [polypeptide binding]; other site 648999012799 conserved gate region; other site 648999012800 putative PBP binding loops; other site 648999012801 ABC-ATPase subunit interface; other site 648999012802 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 648999012803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 648999012804 substrate binding pocket [chemical binding]; other site 648999012805 membrane-bound complex binding site; other site 648999012806 hinge residues; other site 648999012807 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 648999012808 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 648999012809 dimer interface [polypeptide binding]; other site 648999012810 active site 648999012811 non-prolyl cis peptide bond; other site 648999012812 insertion regions; other site 648999012813 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999012814 nudix motif; other site 648999012815 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 648999012816 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 648999012817 putative hydrophobic ligand binding site [chemical binding]; other site 648999012818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999012819 dimerization interface [polypeptide binding]; other site 648999012820 putative DNA binding site [nucleotide binding]; other site 648999012821 putative Zn2+ binding site [ion binding]; other site 648999012822 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 648999012823 amidase catalytic site [active] 648999012824 Zn binding residues [ion binding]; other site 648999012825 substrate binding site [chemical binding]; other site 648999012826 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 648999012827 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 648999012828 active site 648999012829 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 648999012830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 648999012831 YCII-related domain; Region: YCII; cl00999 648999012832 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 648999012833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999012834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999012835 DNA binding residues [nucleotide binding] 648999012836 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 648999012837 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 648999012838 Walker A/P-loop; other site 648999012839 ATP binding site [chemical binding]; other site 648999012840 Q-loop/lid; other site 648999012841 ABC transporter signature motif; other site 648999012842 Walker B; other site 648999012843 D-loop; other site 648999012844 H-loop/switch region; other site 648999012845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 648999012846 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 648999012847 Walker A/P-loop; other site 648999012848 ATP binding site [chemical binding]; other site 648999012849 Q-loop/lid; other site 648999012850 ABC transporter signature motif; other site 648999012851 Walker B; other site 648999012852 D-loop; other site 648999012853 H-loop/switch region; other site 648999012854 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 648999012855 TM-ABC transporter signature motif; other site 648999012856 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 648999012857 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 648999012858 TM-ABC transporter signature motif; other site 648999012859 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999012860 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 648999012861 Helix-turn-helix domains; Region: HTH; cl00088 648999012862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999012863 MarR family; Region: MarR; pfam01047 648999012864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 648999012865 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 648999012866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999012867 Walker A/P-loop; other site 648999012868 ATP binding site [chemical binding]; other site 648999012869 Q-loop/lid; other site 648999012870 ABC transporter signature motif; other site 648999012871 Walker B; other site 648999012872 D-loop; other site 648999012873 H-loop/switch region; other site 648999012874 DivIVA protein; Region: DivIVA; pfam05103 648999012875 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999012876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999012877 DNA-binding site [nucleotide binding]; DNA binding site 648999012878 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 648999012879 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 648999012880 active site 648999012881 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 648999012882 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 648999012883 Zn binding site [ion binding]; other site 648999012884 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 648999012885 ribonuclease; Region: Ribonuclease; pfam00545 648999012886 active site 648999012887 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 648999012888 RNAase interaction site [polypeptide binding]; other site 648999012889 HD domain; Region: HD_4; pfam13328 648999012890 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999012891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 648999012892 Amb_all domain; Region: Amb_all; smart00656 648999012893 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999012894 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999012895 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 648999012896 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 648999012897 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 648999012898 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 648999012899 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 648999012900 metal binding site [ion binding]; metal-binding site 648999012901 substrate binding pocket [chemical binding]; other site 648999012902 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 648999012903 glucuronate isomerase; Reviewed; Region: PRK02925 648999012904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999012905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999012906 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999012907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999012908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999012909 DNA binding site [nucleotide binding] 648999012910 domain linker motif; other site 648999012911 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999012912 dimerization interface [polypeptide binding]; other site 648999012913 ligand binding site [chemical binding]; other site 648999012914 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999012915 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 648999012916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012917 dimer interface [polypeptide binding]; other site 648999012918 putative PBP binding loops; other site 648999012919 ABC-ATPase subunit interface; other site 648999012920 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999012921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999012922 dimer interface [polypeptide binding]; other site 648999012923 conserved gate region; other site 648999012924 putative PBP binding loops; other site 648999012925 ABC-ATPase subunit interface; other site 648999012926 Methane oxygenase PmoA; Region: PmoA; pfam14100 648999012927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 648999012928 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 648999012929 substrate binding site [chemical binding]; other site 648999012930 ATP binding site [chemical binding]; other site 648999012931 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 648999012932 active site 648999012933 intersubunit interface [polypeptide binding]; other site 648999012934 catalytic residue [active] 648999012935 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 648999012936 putative metal binding site [ion binding]; other site 648999012937 phage tail protein domain; Region: tail_TIGR02242 648999012938 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 648999012939 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 648999012940 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 648999012941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 648999012942 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 648999012943 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 648999012944 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 648999012945 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 648999012946 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 648999012947 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 648999012948 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 648999012949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999012950 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 648999012951 acyl-activating enzyme (AAE) consensus motif; other site 648999012952 AMP binding site [chemical binding]; other site 648999012953 active site 648999012954 CoA binding site [chemical binding]; other site 648999012955 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 648999012956 CoenzymeA binding site [chemical binding]; other site 648999012957 subunit interaction site [polypeptide binding]; other site 648999012958 PHB binding site; other site 648999012959 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 648999012960 cyclase homology domain; Region: CHD; cd07302 648999012961 nucleotidyl binding site; other site 648999012962 metal binding site [ion binding]; metal-binding site 648999012963 dimer interface [polypeptide binding]; other site 648999012964 AAA ATPase domain; Region: AAA_16; pfam13191 648999012965 AAA ATPase domain; Region: AAA_16; pfam13191 648999012966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999012967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999012968 DNA binding residues [nucleotide binding] 648999012969 dimerization interface [polypeptide binding]; other site 648999012970 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999012971 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 648999012972 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999012973 Y-family of DNA polymerases; Region: PolY; cl12025 648999012974 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 648999012975 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 648999012976 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 648999012977 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 648999012978 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 648999012979 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 648999012980 carboxyltransferase (CT) interaction site; other site 648999012981 biotinylation site [posttranslational modification]; other site 648999012982 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 648999012983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 648999012984 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999012985 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 648999012986 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 648999012987 putative hydrophobic ligand binding site [chemical binding]; other site 648999012988 active site 648999012989 catalytic residues_2 [active] 648999012990 catalytic residues_1 [active] 648999012991 Cupin domain; Region: Cupin_2; pfam07883 648999012992 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 648999012993 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999012994 dimer interface [polypeptide binding]; other site 648999012995 active site 648999012996 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999012997 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999012998 active site 648999012999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999013000 Coenzyme A binding pocket [chemical binding]; other site 648999013001 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 648999013002 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999013003 acyl-activating enzyme (AAE) consensus motif; other site 648999013004 AMP binding site [chemical binding]; other site 648999013005 active site 648999013006 CoA binding site [chemical binding]; other site 648999013007 Phosphopantetheine attachment site; Region: PP-binding; cl09936 648999013008 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999013009 active site 648999013010 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 648999013011 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 648999013012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999013013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999013014 acyl-activating enzyme (AAE) consensus motif; other site 648999013015 acyl-activating enzyme (AAE) consensus motif; other site 648999013016 AMP binding site [chemical binding]; other site 648999013017 active site 648999013018 CoA binding site [chemical binding]; other site 648999013019 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 648999013020 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 648999013021 dimer interface [polypeptide binding]; other site 648999013022 active site 648999013023 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 648999013024 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 648999013025 dimer interface [polypeptide binding]; other site 648999013026 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 648999013027 active site 648999013028 Fe binding site [ion binding]; other site 648999013029 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 648999013030 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 648999013031 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 648999013032 tetramer interface [polypeptide binding]; other site 648999013033 TPP-binding site [chemical binding]; other site 648999013034 heterodimer interface [polypeptide binding]; other site 648999013035 phosphorylation loop region [posttranslational modification] 648999013036 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999013037 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 648999013038 PYR/PP interface [polypeptide binding]; other site 648999013039 dimer interface [polypeptide binding]; other site 648999013040 TPP binding site [chemical binding]; other site 648999013041 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999013042 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 648999013043 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 648999013044 active site 648999013045 catalytic triad [active] 648999013046 oxyanion hole [active] 648999013047 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 648999013048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999013049 motif II; other site 648999013050 Protein of unknown function (DUF419); Region: DUF419; cl15265 648999013051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013052 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999013053 putative substrate translocation pore; other site 648999013054 acyl-CoA synthetase; Validated; Region: PRK06188 648999013055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999013056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999013057 acyl-activating enzyme (AAE) consensus motif; other site 648999013058 AMP binding site [chemical binding]; other site 648999013059 active site 648999013060 CoA binding site [chemical binding]; other site 648999013061 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 648999013062 active site 648999013063 catalytic triad [active] 648999013064 oxyanion hole [active] 648999013065 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999013066 Cytochrome P450; Region: p450; cl12078 648999013067 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 648999013068 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 648999013069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999013070 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 648999013071 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 648999013072 active site 648999013073 substrate binding site [chemical binding]; other site 648999013074 FMN binding site [chemical binding]; other site 648999013075 putative catalytic residues [active] 648999013076 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 648999013077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999013078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999013079 homodimer interface [polypeptide binding]; other site 648999013080 catalytic residue [active] 648999013081 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 648999013082 serine hydroxymethyltransferase; Provisional; Region: PRK13580 648999013083 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 648999013084 dimer interface [polypeptide binding]; other site 648999013085 active site 648999013086 glycine-pyridoxal phosphate binding site [chemical binding]; other site 648999013087 folate binding site [chemical binding]; other site 648999013088 Hemerythrin-like domain; Region: Hr-like; cd12108 648999013089 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999013090 active site 648999013091 catalytic residues [active] 648999013092 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999013093 catalytic residues [active] 648999013094 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 648999013095 putative substrate binding site [chemical binding]; other site 648999013096 putative ATP binding site [chemical binding]; other site 648999013097 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999013098 catalytic core [active] 648999013099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013101 active site 648999013102 phosphorylation site [posttranslational modification] 648999013103 intermolecular recognition site; other site 648999013104 dimerization interface [polypeptide binding]; other site 648999013105 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 648999013106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999013107 Histidine kinase; Region: HisKA_3; pfam07730 648999013108 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999013109 Mg2+ binding site [ion binding]; other site 648999013110 G-X-G motif; other site 648999013111 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999013112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999013113 Walker A/P-loop; other site 648999013114 ATP binding site [chemical binding]; other site 648999013115 Q-loop/lid; other site 648999013116 ABC transporter signature motif; other site 648999013117 Walker B; other site 648999013118 D-loop; other site 648999013119 H-loop/switch region; other site 648999013120 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 648999013121 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 648999013122 MoxR-like ATPases [General function prediction only]; Region: COG0714 648999013123 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 648999013124 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 648999013125 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 648999013126 metal ion-dependent adhesion site (MIDAS); other site 648999013127 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 648999013128 nucleotide binding site [chemical binding]; other site 648999013129 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 648999013130 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 648999013131 putative DNA binding site [nucleotide binding]; other site 648999013132 putative Zn2+ binding site [ion binding]; other site 648999013133 AsnC family; Region: AsnC_trans_reg; pfam01037 648999013134 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 648999013135 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 648999013136 tetramer interface [polypeptide binding]; other site 648999013137 TPP-binding site [chemical binding]; other site 648999013138 heterodimer interface [polypeptide binding]; other site 648999013139 phosphorylation loop region [posttranslational modification] 648999013140 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999013141 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 648999013142 alpha subunit interface [polypeptide binding]; other site 648999013143 TPP binding site [chemical binding]; other site 648999013144 heterodimer interface [polypeptide binding]; other site 648999013145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999013146 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999013147 E3 interaction surface; other site 648999013148 lipoyl attachment site [posttranslational modification]; other site 648999013149 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 648999013150 e3 binding domain; Region: E3_binding; pfam02817 648999013151 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999013152 Bacterial Ig-like domain; Region: Big_5; pfam13205 648999013153 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 648999013154 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 648999013155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 648999013156 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 648999013157 Strictosidine synthase; Region: Str_synth; pfam03088 648999013158 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999013159 anti sigma factor interaction site; other site 648999013160 regulatory phosphorylation site [posttranslational modification]; other site 648999013161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 648999013162 FOG: CBS domain [General function prediction only]; Region: COG0517 648999013163 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 648999013164 BON domain; Region: BON; pfam04972 648999013165 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 648999013166 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 648999013167 intersubunit interface [polypeptide binding]; other site 648999013168 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 648999013169 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 648999013170 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 648999013171 Lsr2; Region: Lsr2; pfam11774 648999013172 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 648999013173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999013174 Walker A motif; other site 648999013175 ATP binding site [chemical binding]; other site 648999013176 Walker B motif; other site 648999013177 arginine finger; other site 648999013178 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 648999013179 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 648999013180 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 648999013181 ATP binding site [chemical binding]; other site 648999013182 Mg++ binding site [ion binding]; other site 648999013183 motif III; other site 648999013184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999013185 nucleotide binding region [chemical binding]; other site 648999013186 ATP-binding site [chemical binding]; other site 648999013187 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 648999013188 RNA binding site [nucleotide binding]; other site 648999013189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999013190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013192 active site 648999013193 phosphorylation site [posttranslational modification] 648999013194 intermolecular recognition site; other site 648999013195 dimerization interface [polypeptide binding]; other site 648999013196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013197 DNA binding residues [nucleotide binding] 648999013198 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 648999013199 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 648999013200 putative substrate binding site [chemical binding]; other site 648999013201 active site 648999013202 dimerization interface [polypeptide binding]; other site 648999013203 putative DNA binding site [nucleotide binding]; other site 648999013204 putative Zn2+ binding site [ion binding]; other site 648999013205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 648999013206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999013207 Cytochrome P450; Region: p450; cl12078 648999013208 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 648999013209 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 648999013210 oligomerization interface [polypeptide binding]; other site 648999013211 active site 648999013212 metal binding site [ion binding]; metal-binding site 648999013213 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 648999013214 active site 648999013215 dimer interface [polypeptide binding]; other site 648999013216 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 648999013217 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 648999013218 Ligand Binding Site [chemical binding]; other site 648999013219 Molecular Tunnel; other site 648999013220 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 648999013221 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 648999013222 active site 648999013223 Zn2+ binding site [ion binding]; other site 648999013224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 648999013225 Mg2+ binding site [ion binding]; other site 648999013226 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 648999013227 Domain of unknown function (DUF305); Region: DUF305; pfam03713 648999013228 Histidine kinase; Region: HisKA_3; pfam07730 648999013229 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999013230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013232 active site 648999013233 phosphorylation site [posttranslational modification] 648999013234 intermolecular recognition site; other site 648999013235 dimerization interface [polypeptide binding]; other site 648999013236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013237 DNA binding residues [nucleotide binding] 648999013238 dimerization interface [polypeptide binding]; other site 648999013239 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999013240 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999013241 Walker A/P-loop; other site 648999013242 ATP binding site [chemical binding]; other site 648999013243 Q-loop/lid; other site 648999013244 ABC transporter signature motif; other site 648999013245 Walker B; other site 648999013246 D-loop; other site 648999013247 H-loop/switch region; other site 648999013248 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999013249 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 648999013250 FtsX-like permease family; Region: FtsX; pfam02687 648999013251 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 648999013252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999013253 active site 648999013254 ATP binding site [chemical binding]; other site 648999013255 substrate binding site [chemical binding]; other site 648999013256 activation loop (A-loop); other site 648999013257 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999013258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999013259 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 648999013260 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 648999013261 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 648999013262 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 648999013263 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 648999013264 putative active site [active] 648999013265 putative dimer interface [polypeptide binding]; other site 648999013266 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 648999013267 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 648999013268 Predicted membrane protein [Function unknown]; Region: COG2119 648999013269 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 648999013270 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 648999013271 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 648999013272 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 648999013273 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 648999013274 NAD(P) binding site [chemical binding]; other site 648999013275 homodimer interface [polypeptide binding]; other site 648999013276 substrate binding site [chemical binding]; other site 648999013277 active site 648999013278 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 648999013279 Chain length determinant protein; Region: Wzz; cl15801 648999013280 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 648999013281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 648999013282 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 648999013283 Low molecular weight phosphatase family; Region: LMWPc; cl00105 648999013284 active site 648999013285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999013286 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 648999013287 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 648999013288 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 648999013289 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 648999013290 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 648999013291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999013292 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 648999013293 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999013294 NodB motif; other site 648999013295 putative active site [active] 648999013296 putative catalytic site [active] 648999013297 putative Zn binding site [ion binding]; other site 648999013298 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 648999013299 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 648999013300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999013301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999013302 DNA binding site [nucleotide binding] 648999013303 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 648999013304 putative dimerization interface [polypeptide binding]; other site 648999013305 putative ligand binding site [chemical binding]; other site 648999013306 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 648999013307 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 648999013308 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999013309 S-formylglutathione hydrolase; Region: PLN02442 648999013310 Predicted esterase [General function prediction only]; Region: COG0627 648999013311 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 648999013312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999013313 motif II; other site 648999013314 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 648999013315 hypothetical protein; Reviewed; Region: PRK09588 648999013316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999013317 non-specific DNA binding site [nucleotide binding]; other site 648999013318 salt bridge; other site 648999013319 sequence-specific DNA binding site [nucleotide binding]; other site 648999013320 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 648999013321 RibD C-terminal domain; Region: RibD_C; cl17279 648999013322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999013323 Zn2+ binding site [ion binding]; other site 648999013324 Mg2+ binding site [ion binding]; other site 648999013325 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 648999013326 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999013327 Methyltransferase domain; Region: Methyltransf_11; pfam08241 648999013328 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 648999013329 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 648999013330 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999013331 active site 648999013332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999013333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999013334 active site 648999013335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013336 NADH(P)-binding; Region: NAD_binding_10; pfam13460 648999013337 NAD(P) binding site [chemical binding]; other site 648999013338 active site 648999013339 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 648999013340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999013341 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999013342 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 648999013343 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 648999013344 transmembrane helices; other site 648999013345 TIR domain; Region: TIR_2; pfam13676 648999013346 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999013347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999013348 NACHT domain; Region: NACHT; pfam05729 648999013349 Walker A motif; other site 648999013350 ATP binding site [chemical binding]; other site 648999013351 Walker B motif; other site 648999013352 arginine finger; other site 648999013353 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 648999013354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 648999013355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 648999013356 WD40 repeats; Region: WD40; smart00320 648999013357 PQQ-like domain; Region: PQQ_2; pfam13360 648999013358 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 648999013359 structural tetrad; other site 648999013360 FOG: WD40 repeat [General function prediction only]; Region: COG2319 648999013361 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 648999013362 structural tetrad; other site 648999013363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999013364 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999013365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999013366 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999013367 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 648999013368 active site 648999013369 catalytic residues [active] 648999013370 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999013371 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999013372 putative sugar binding sites [chemical binding]; other site 648999013373 Q-X-W motif; other site 648999013374 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999013375 Helix-turn-helix domain; Region: HTH_20; pfam12840 648999013376 putative DNA binding site [nucleotide binding]; other site 648999013377 dimerization interface [polypeptide binding]; other site 648999013378 putative Zn2+ binding site [ion binding]; other site 648999013379 DinB superfamily; Region: DinB_2; pfam12867 648999013380 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 648999013381 SmpB-tmRNA interface; other site 648999013382 YhhN-like protein; Region: YhhN; cl01505 648999013383 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 648999013384 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 648999013385 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999013386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999013387 DNA-binding site [nucleotide binding]; DNA binding site 648999013388 heat shock protein 90; Provisional; Region: PRK05218 648999013389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999013390 ATP binding site [chemical binding]; other site 648999013391 Mg2+ binding site [ion binding]; other site 648999013392 G-X-G motif; other site 648999013393 short chain dehydrogenase; Validated; Region: PRK08264 648999013394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013395 NAD(P) binding site [chemical binding]; other site 648999013396 active site 648999013397 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999013398 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999013399 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 648999013400 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 648999013401 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999013402 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 648999013403 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 648999013404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 648999013405 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 648999013406 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 648999013407 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 648999013408 active site 648999013409 Zn binding site [ion binding]; other site 648999013410 Transglycosylase; Region: Transgly; pfam00912 648999013411 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 648999013412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999013413 putative lipid kinase; Reviewed; Region: PRK13057 648999013414 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 648999013415 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 648999013416 FAD binding domain; Region: FAD_binding_4; pfam01565 648999013417 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 648999013418 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 648999013419 classical (c) SDRs; Region: SDR_c; cd05233 648999013420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999013421 NAD(P) binding site [chemical binding]; other site 648999013422 active site 648999013423 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 648999013424 active site 648999013425 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 648999013426 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 648999013427 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 648999013428 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 648999013429 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 648999013430 Cellulose binding domain; Region: CBM_2; pfam00553 648999013431 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 648999013432 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 648999013433 Uncharacterized conserved protein [Function unknown]; Region: COG1359 648999013434 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 648999013435 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 648999013436 active site 648999013437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013439 active site 648999013440 phosphorylation site [posttranslational modification] 648999013441 intermolecular recognition site; other site 648999013442 dimerization interface [polypeptide binding]; other site 648999013443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013444 DNA binding residues [nucleotide binding] 648999013445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999013446 Histidine kinase; Region: HisKA_3; pfam07730 648999013447 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 648999013448 NAD-dependent deacetylase; Provisional; Region: PRK00481 648999013449 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 648999013450 NAD+ binding site [chemical binding]; other site 648999013451 substrate binding site [chemical binding]; other site 648999013452 Zn binding site [ion binding]; other site 648999013453 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999013454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999013455 AAA ATPase domain; Region: AAA_16; pfam13191 648999013456 Walker A motif; other site 648999013457 ATP binding site [chemical binding]; other site 648999013458 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013460 dimerization interface [polypeptide binding]; other site 648999013461 DNA binding residues [nucleotide binding] 648999013462 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 648999013463 putative lipid kinase; Reviewed; Region: PRK13057 648999013464 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 648999013465 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 648999013466 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999013467 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 648999013468 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013470 active site 648999013471 phosphorylation site [posttranslational modification] 648999013472 intermolecular recognition site; other site 648999013473 dimerization interface [polypeptide binding]; other site 648999013474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013475 DNA binding residues [nucleotide binding] 648999013476 dimerization interface [polypeptide binding]; other site 648999013477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999013478 Histidine kinase; Region: HisKA_3; pfam07730 648999013479 DNA polymerase IV; Validated; Region: PRK03858 648999013480 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 648999013481 active site 648999013482 DNA binding site [nucleotide binding] 648999013483 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 648999013484 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 648999013485 active site 648999013486 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 648999013487 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999013488 sugar binding site [chemical binding]; other site 648999013489 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 648999013490 amidase catalytic site [active] 648999013491 Zn binding residues [ion binding]; other site 648999013492 substrate binding site [chemical binding]; other site 648999013493 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 648999013494 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999013495 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999013496 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 648999013497 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999013498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999013499 active site 648999013500 ATP binding site [chemical binding]; other site 648999013501 substrate binding site [chemical binding]; other site 648999013502 activation loop (A-loop); other site 648999013503 Conserved TM helix; Region: TM_helix; pfam05552 648999013504 transketolase; Reviewed; Region: PRK05899 648999013505 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 648999013506 TPP-binding site [chemical binding]; other site 648999013507 dimer interface [polypeptide binding]; other site 648999013508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 648999013509 PYR/PP interface [polypeptide binding]; other site 648999013510 dimer interface [polypeptide binding]; other site 648999013511 TPP binding site [chemical binding]; other site 648999013512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999013513 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 648999013514 hypothetical protein; Provisional; Region: PRK04233 648999013515 SEC-C motif; Region: SEC-C; pfam02810 648999013516 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 648999013517 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 648999013518 Fructosamine kinase; Region: Fructosamin_kin; cl17579 648999013519 Phosphotransferase enzyme family; Region: APH; pfam01636 648999013520 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 648999013521 active site 648999013522 putative catalytic site [active] 648999013523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999013524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999013525 active site 648999013526 phosphorylation site [posttranslational modification] 648999013527 intermolecular recognition site; other site 648999013528 dimerization interface [polypeptide binding]; other site 648999013529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999013530 DNA binding residues [nucleotide binding] 648999013531 dimerization interface [polypeptide binding]; other site 648999013532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999013533 Histidine kinase; Region: HisKA_3; pfam07730 648999013534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999013535 ATP binding site [chemical binding]; other site 648999013536 Mg2+ binding site [ion binding]; other site 648999013537 G-X-G motif; other site 648999013538 YCII-related domain; Region: YCII; cl00999 648999013539 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 648999013540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999013541 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999013542 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999013543 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 648999013544 lycopene cyclase; Region: lycopene_cycl; TIGR01789 648999013545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999013546 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999013547 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 648999013548 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 648999013549 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 648999013550 RNA/DNA hybrid binding site [nucleotide binding]; other site 648999013551 active site 648999013552 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 648999013553 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 648999013554 Subtilisin inhibitor-like; Region: SSI; cl11594 648999013555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999013556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999013557 dimer interface [polypeptide binding]; other site 648999013558 conserved gate region; other site 648999013559 putative PBP binding loops; other site 648999013560 ABC-ATPase subunit interface; other site 648999013561 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 648999013562 peptide binding site [polypeptide binding]; other site 648999013563 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999013564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999013565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999013566 ABC-ATPase subunit interface; other site 648999013567 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999013568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999013569 Walker A/P-loop; other site 648999013570 ATP binding site [chemical binding]; other site 648999013571 Q-loop/lid; other site 648999013572 ABC transporter signature motif; other site 648999013573 Walker B; other site 648999013574 D-loop; other site 648999013575 H-loop/switch region; other site 648999013576 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999013577 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 648999013578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999013579 Walker A/P-loop; other site 648999013580 ATP binding site [chemical binding]; other site 648999013581 Q-loop/lid; other site 648999013582 ABC transporter signature motif; other site 648999013583 Walker B; other site 648999013584 D-loop; other site 648999013585 H-loop/switch region; other site 648999013586 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999013587 oxidoreductase; Provisional; Region: PRK12743 648999013588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013589 NAD(P) binding site [chemical binding]; other site 648999013590 active site 648999013591 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 648999013592 B3/4 domain; Region: B3_4; pfam03483 648999013593 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 648999013594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999013595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999013596 DNA-binding site [nucleotide binding]; DNA binding site 648999013597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999013598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999013599 homodimer interface [polypeptide binding]; other site 648999013600 catalytic residue [active] 648999013601 Predicted transcriptional regulator [Transcription]; Region: COG2378 648999013602 HTH domain; Region: HTH_11; pfam08279 648999013603 WYL domain; Region: WYL; pfam13280 648999013604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999013605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999013606 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 648999013607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 648999013608 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 648999013609 classical (c) SDRs; Region: SDR_c; cd05233 648999013610 NAD(P) binding site [chemical binding]; other site 648999013611 active site 648999013612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999013613 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 648999013614 catalytic site [active] 648999013615 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999013616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999013617 DNA-binding site [nucleotide binding]; DNA binding site 648999013618 FCD domain; Region: FCD; pfam07729 648999013619 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999013620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013621 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 648999013622 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 648999013623 NAD binding site [chemical binding]; other site 648999013624 catalytic Zn binding site [ion binding]; other site 648999013625 substrate binding site [chemical binding]; other site 648999013626 structural Zn binding site [ion binding]; other site 648999013627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 648999013628 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 648999013629 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999013630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 648999013631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013632 putative substrate translocation pore; other site 648999013633 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 648999013634 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 648999013635 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 648999013636 NAD binding site [chemical binding]; other site 648999013637 substrate binding site [chemical binding]; other site 648999013638 catalytic Zn binding site [ion binding]; other site 648999013639 structural Zn binding site [ion binding]; other site 648999013640 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 648999013641 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 648999013642 active site 648999013643 metal binding site [ion binding]; metal-binding site 648999013644 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 648999013645 short chain dehydrogenase; Provisional; Region: PRK06701 648999013646 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 648999013647 NAD binding site [chemical binding]; other site 648999013648 metal binding site [ion binding]; metal-binding site 648999013649 active site 648999013650 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 648999013651 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999013652 molybdopterin cofactor binding site; other site 648999013653 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999013654 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 648999013655 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 648999013656 molybdopterin cofactor binding site; other site 648999013657 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 648999013658 4Fe-4S binding domain; Region: Fer4_6; pfam12837 648999013659 selenocysteine synthase; Provisional; Region: PRK04311 648999013660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999013661 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 648999013662 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 648999013663 G1 box; other site 648999013664 GTP/Mg2+ binding site [chemical binding]; other site 648999013665 G2 box; other site 648999013666 Switch I region; other site 648999013667 G3 box; other site 648999013668 Switch II region; other site 648999013669 G5 box; other site 648999013670 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 648999013671 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 648999013672 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 648999013673 Domain of unknown function DUF21; Region: DUF21; pfam01595 648999013674 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 648999013675 Transporter associated domain; Region: CorC_HlyC; smart01091 648999013676 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 648999013677 Ligand Binding Site [chemical binding]; other site 648999013678 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999013679 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999013680 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 648999013681 MarR family; Region: MarR; pfam01047 648999013682 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 648999013683 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 648999013684 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 648999013685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 648999013686 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 648999013687 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 648999013688 lipoyl attachment site [posttranslational modification]; other site 648999013689 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 648999013690 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 648999013691 phosphopeptide binding site; other site 648999013692 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 648999013693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999013694 DNA binding residues [nucleotide binding] 648999013695 Bifunctional nuclease; Region: DNase-RNase; pfam02577 648999013696 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999013697 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 648999013698 DNA binding residues [nucleotide binding] 648999013699 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 648999013700 apolar tunnel; other site 648999013701 heme binding site [chemical binding]; other site 648999013702 dimerization interface [polypeptide binding]; other site 648999013703 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 648999013704 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 648999013705 heme-binding site [chemical binding]; other site 648999013706 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 648999013707 FAD binding pocket [chemical binding]; other site 648999013708 conserved FAD binding motif [chemical binding]; other site 648999013709 phosphate binding motif [ion binding]; other site 648999013710 beta-alpha-beta structure motif; other site 648999013711 NAD binding pocket [chemical binding]; other site 648999013712 DivIVA domain; Region: DivI1A_domain; TIGR03544 648999013713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013714 NADH(P)-binding; Region: NAD_binding_10; pfam13460 648999013715 NAD(P) binding site [chemical binding]; other site 648999013716 active site 648999013717 NAD-dependent deacetylase; Provisional; Region: PRK00481 648999013718 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 648999013719 glycine dehydrogenase; Provisional; Region: PRK05367 648999013720 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999013721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999013722 catalytic residue [active] 648999013723 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 648999013724 tetramer interface [polypeptide binding]; other site 648999013725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999013726 catalytic residue [active] 648999013727 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 648999013728 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 648999013729 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 648999013730 active site 648999013731 catalytic residues [active] 648999013732 metal binding site [ion binding]; metal-binding site 648999013733 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999013734 hypothetical protein; Provisional; Region: PRK10621 648999013735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 648999013736 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999013737 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 648999013738 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 648999013739 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 648999013740 NAD(P) binding pocket [chemical binding]; other site 648999013741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999013742 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 648999013743 active site 648999013744 DNA binding site [nucleotide binding] 648999013745 Int/Topo IB signature motif; other site 648999013746 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 648999013747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999013748 Walker A/P-loop; other site 648999013749 ATP binding site [chemical binding]; other site 648999013750 Q-loop/lid; other site 648999013751 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 648999013752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999013753 Walker A/P-loop; other site 648999013754 ATP binding site [chemical binding]; other site 648999013755 Q-loop/lid; other site 648999013756 ABC transporter signature motif; other site 648999013757 Walker B; other site 648999013758 D-loop; other site 648999013759 H-loop/switch region; other site 648999013760 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999013761 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999013762 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 648999013763 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999013764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999013765 pyridoxamine kinase; Validated; Region: PRK05756 648999013766 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 648999013767 dimer interface [polypeptide binding]; other site 648999013768 pyridoxal binding site [chemical binding]; other site 648999013769 ATP binding site [chemical binding]; other site 648999013770 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 648999013771 classical (c) SDRs; Region: SDR_c; cd05233 648999013772 short chain dehydrogenase; Provisional; Region: PRK06123 648999013773 NAD(P) binding site [chemical binding]; other site 648999013774 active site 648999013775 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 648999013776 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999013777 YCII-related domain; Region: YCII; cl00999 648999013778 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 648999013779 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 648999013780 catalytic triad [active] 648999013781 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 648999013782 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 648999013783 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 648999013784 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 648999013785 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 648999013786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 648999013787 putative acyl-acceptor binding pocket; other site 648999013788 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999013789 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 648999013790 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 648999013791 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999013792 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 648999013793 active site 648999013794 catalytic site [active] 648999013795 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 648999013796 thymidine kinase; Provisional; Region: PRK04296 648999013797 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 648999013798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999013799 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999013800 active site 648999013801 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 648999013802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999013803 active site 648999013804 Int/Topo IB signature motif; other site 648999013805 DNA binding site [nucleotide binding] 648999013806 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 648999013807 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 648999013808 putative dimer interface [polypeptide binding]; other site 648999013809 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999013810 Coenzyme A binding pocket [chemical binding]; other site 648999013811 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 648999013812 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 648999013813 catalytic triad [active] 648999013814 conserved cis-peptide bond; other site 648999013815 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 648999013816 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999013817 TIGR04222 domain; Region: near_uncomplex 648999013818 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 648999013819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999013821 putative substrate translocation pore; other site 648999013822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013823 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 648999013824 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 648999013825 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 648999013826 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 648999013827 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 648999013828 NADP binding site [chemical binding]; other site 648999013829 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999013830 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999013831 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 648999013832 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 648999013833 catalytic residues [active] 648999013834 catalytic nucleophile [active] 648999013835 Presynaptic Site I dimer interface [polypeptide binding]; other site 648999013836 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 648999013837 Synaptic Flat tetramer interface [polypeptide binding]; other site 648999013838 Synaptic Site I dimer interface [polypeptide binding]; other site 648999013839 DNA binding site [nucleotide binding] 648999013840 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 648999013841 DNA-binding interface [nucleotide binding]; DNA binding site 648999013842 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 648999013843 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999013844 homodimer interface [polypeptide binding]; other site 648999013845 glycosyltransferase, MGT family; Region: MGT; TIGR01426 648999013846 active site 648999013847 TDP-binding site; other site 648999013848 acceptor substrate-binding pocket; other site 648999013849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999013850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999013851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013852 NADH(P)-binding; Region: NAD_binding_10; pfam13460 648999013853 NAD(P) binding site [chemical binding]; other site 648999013854 active site 648999013855 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 648999013856 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 648999013857 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 648999013858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999013859 S-adenosylmethionine binding site [chemical binding]; other site 648999013860 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 648999013861 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 648999013862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999013863 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 648999013864 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 648999013865 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 648999013866 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 648999013867 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 648999013868 putative alpha-glucosidase; Provisional; Region: PRK10658 648999013869 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 648999013870 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 648999013871 active site 648999013872 homotrimer interface [polypeptide binding]; other site 648999013873 catalytic site [active] 648999013874 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 648999013875 MarR family; Region: MarR_2; cl17246 648999013876 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999013877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999013878 nucleotide binding site [chemical binding]; other site 648999013879 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 648999013880 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 648999013881 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 648999013882 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 648999013883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999013884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999013885 DNA binding site [nucleotide binding] 648999013886 domain linker motif; other site 648999013887 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999013888 dimerization interface [polypeptide binding]; other site 648999013889 ligand binding site [chemical binding]; other site 648999013890 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 648999013891 nudix motif; other site 648999013892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999013893 short chain dehydrogenase; Provisional; Region: PRK06181 648999013894 NAD(P) binding site [chemical binding]; other site 648999013895 active site 648999013896 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 648999013897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999013898 MFS/sugar transport protein; Region: MFS_2; pfam13347 648999013899 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999013900 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 648999013901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999013902 putative substrate translocation pore; other site 648999013903 POT family; Region: PTR2; cl17359 648999013904 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 648999013905 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 648999013906 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 648999013907 Ligand binding site; other site 648999013908 DXD motif; other site 648999013909 Putative Catalytic site; other site 648999013910 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 648999013911 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 648999013912 putative active site [active] 648999013913 catalytic triad [active] 648999013914 putative dimer interface [polypeptide binding]; other site 648999013915 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999013916 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999013917 AAA ATPase domain; Region: AAA_16; pfam13191 648999013918 Predicted ATPase [General function prediction only]; Region: COG3903 648999013919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999013920 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999013921 Walker A/P-loop; other site 648999013922 ATP binding site [chemical binding]; other site 648999013923 Q-loop/lid; other site 648999013924 ABC transporter signature motif; other site 648999013925 Walker B; other site 648999013926 D-loop; other site 648999013927 H-loop/switch region; other site 648999013928 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 648999013929 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999013930 MutL protein; Region: MutL; pfam13941 648999013931 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 648999013932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999013933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999013934 active site 648999013935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 648999013936 CsbD-like; Region: CsbD; pfam05532 648999013937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999013938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999013939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 648999013940 dimerization interface [polypeptide binding]; other site 648999013941 EamA-like transporter family; Region: EamA; pfam00892 648999013942 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999013943 catalytic core [active] 648999013944 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 648999013945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999013946 putative DNA binding site [nucleotide binding]; other site 648999013947 putative Zn2+ binding site [ion binding]; other site 648999013948 AsnC family; Region: AsnC_trans_reg; pfam01037 648999013949 Protein of unknown function (DUF433); Region: DUF433; pfam04255 648999013950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999013951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999013952 active site 648999013953 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 648999013954 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 648999013955 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 648999013956 active site 648999013957 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 648999013958 metal ion-dependent adhesion site (MIDAS); other site 648999013959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999013960 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 648999013961 Walker A motif; other site 648999013962 ATP binding site [chemical binding]; other site 648999013963 Walker B motif; other site 648999013964 arginine finger; other site 648999013965 hypothetical protein; Provisional; Region: PRK11770 648999013966 Domain of unknown function (DUF307); Region: DUF307; pfam03733 648999013967 Domain of unknown function (DUF307); Region: DUF307; pfam03733 648999013968 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 648999013969 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999013970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999013971 DNA binding site [nucleotide binding] 648999013972 domain linker motif; other site 648999013973 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999013974 dimerization interface [polypeptide binding]; other site 648999013975 ligand binding site [chemical binding]; other site 648999013976 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 648999013977 substrate binding site [chemical binding]; other site 648999013978 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 648999013979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999013980 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999013981 Walker A/P-loop; other site 648999013982 ATP binding site [chemical binding]; other site 648999013983 Q-loop/lid; other site 648999013984 ABC transporter signature motif; other site 648999013985 Walker B; other site 648999013986 D-loop; other site 648999013987 H-loop/switch region; other site 648999013988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999013989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999013990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999013991 dimer interface [polypeptide binding]; other site 648999013992 conserved gate region; other site 648999013993 putative PBP binding loops; other site 648999013994 ABC-ATPase subunit interface; other site 648999013995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999013996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999013997 dimer interface [polypeptide binding]; other site 648999013998 conserved gate region; other site 648999013999 putative PBP binding loops; other site 648999014000 ABC-ATPase subunit interface; other site 648999014001 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999014002 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999014003 Walker A/P-loop; other site 648999014004 ATP binding site [chemical binding]; other site 648999014005 Q-loop/lid; other site 648999014006 ABC transporter signature motif; other site 648999014007 Walker B; other site 648999014008 D-loop; other site 648999014009 H-loop/switch region; other site 648999014010 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999014011 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 648999014012 beta-galactosidase; Region: BGL; TIGR03356 648999014013 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 648999014014 non-specific DNA interactions [nucleotide binding]; other site 648999014015 DNA binding site [nucleotide binding] 648999014016 sequence specific DNA binding site [nucleotide binding]; other site 648999014017 putative cAMP binding site [chemical binding]; other site 648999014018 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999014019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999014020 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 648999014021 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 648999014022 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 648999014023 putative active site [active] 648999014024 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 648999014025 Zn binding site [ion binding]; other site 648999014026 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 648999014027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999014028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999014029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 648999014030 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 648999014031 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 648999014032 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 648999014033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999014034 Walker A/P-loop; other site 648999014035 ATP binding site [chemical binding]; other site 648999014036 Q-loop/lid; other site 648999014037 ABC transporter signature motif; other site 648999014038 Walker B; other site 648999014039 D-loop; other site 648999014040 H-loop/switch region; other site 648999014041 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 648999014042 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999014043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999014044 Walker A/P-loop; other site 648999014045 ATP binding site [chemical binding]; other site 648999014046 Q-loop/lid; other site 648999014047 ABC transporter signature motif; other site 648999014048 Walker B; other site 648999014049 D-loop; other site 648999014050 H-loop/switch region; other site 648999014051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999014052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999014053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014054 dimer interface [polypeptide binding]; other site 648999014055 conserved gate region; other site 648999014056 putative PBP binding loops; other site 648999014057 ABC-ATPase subunit interface; other site 648999014058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999014059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014060 dimer interface [polypeptide binding]; other site 648999014061 conserved gate region; other site 648999014062 putative PBP binding loops; other site 648999014063 ABC-ATPase subunit interface; other site 648999014064 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 648999014065 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 648999014066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999014067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999014068 active site 648999014069 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 648999014070 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 648999014071 MOSC domain; Region: MOSC; pfam03473 648999014072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 648999014073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999014074 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 648999014075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999014076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999014077 homodimer interface [polypeptide binding]; other site 648999014078 catalytic residue [active] 648999014079 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 648999014080 Protein of unknown function (DUF664); Region: DUF664; pfam04978 648999014081 DinB superfamily; Region: DinB_2; pfam12867 648999014082 HTH domain; Region: HTH_11; pfam08279 648999014083 WYL domain; Region: WYL; pfam13280 648999014084 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 648999014085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999014086 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999014087 Part of AAA domain; Region: AAA_19; pfam13245 648999014088 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 648999014089 Family description; Region: UvrD_C_2; pfam13538 648999014090 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999014091 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 648999014092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999014093 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 648999014094 Walker A/P-loop; other site 648999014095 ATP binding site [chemical binding]; other site 648999014096 Q-loop/lid; other site 648999014097 ABC transporter signature motif; other site 648999014098 Walker B; other site 648999014099 D-loop; other site 648999014100 H-loop/switch region; other site 648999014101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999014102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014103 active site 648999014104 phosphorylation site [posttranslational modification] 648999014105 intermolecular recognition site; other site 648999014106 dimerization interface [polypeptide binding]; other site 648999014107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999014108 DNA binding residues [nucleotide binding] 648999014109 dimerization interface [polypeptide binding]; other site 648999014110 Histidine kinase; Region: HisKA_3; pfam07730 648999014111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999014112 ATP binding site [chemical binding]; other site 648999014113 Mg2+ binding site [ion binding]; other site 648999014114 G-X-G motif; other site 648999014115 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 648999014116 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999014117 Walker A/P-loop; other site 648999014118 ATP binding site [chemical binding]; other site 648999014119 Q-loop/lid; other site 648999014120 ABC transporter signature motif; other site 648999014121 Walker B; other site 648999014122 D-loop; other site 648999014123 H-loop/switch region; other site 648999014124 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999014125 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999014126 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999014127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999014128 catalytic residue [active] 648999014129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014130 S-adenosylmethionine binding site [chemical binding]; other site 648999014131 CAAX protease self-immunity; Region: Abi; pfam02517 648999014132 Histidine kinase; Region: HisKA_3; pfam07730 648999014133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999014134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014135 active site 648999014136 phosphorylation site [posttranslational modification] 648999014137 intermolecular recognition site; other site 648999014138 dimerization interface [polypeptide binding]; other site 648999014139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999014140 DNA binding residues [nucleotide binding] 648999014141 dimerization interface [polypeptide binding]; other site 648999014142 Protein of unknown function (DUF429); Region: DUF429; pfam04250 648999014143 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 648999014144 homodimer interface [polypeptide binding]; other site 648999014145 chemical substrate binding site [chemical binding]; other site 648999014146 oligomer interface [polypeptide binding]; other site 648999014147 metal binding site [ion binding]; metal-binding site 648999014148 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 648999014149 Uncharacterized conserved protein [Function unknown]; Region: COG3410 648999014150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014151 S-adenosylmethionine binding site [chemical binding]; other site 648999014152 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 648999014153 active site 648999014154 Mn binding site [ion binding]; other site 648999014155 NUDIX domain; Region: NUDIX; pfam00293 648999014156 nudix motif; other site 648999014157 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999014158 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999014159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014160 S-adenosylmethionine binding site [chemical binding]; other site 648999014161 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 648999014162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999014163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999014164 DNA binding site [nucleotide binding] 648999014165 domain linker motif; other site 648999014166 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 648999014167 ligand binding site [chemical binding]; other site 648999014168 dimerization interface [polypeptide binding]; other site 648999014169 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999014170 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999014171 Protein of unknown function (DUF993); Region: DUF993; pfam06187 648999014172 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999014173 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 648999014174 active site 648999014175 oxyanion hole [active] 648999014176 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 648999014177 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999014178 DNA binding residues [nucleotide binding] 648999014179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999014180 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 648999014181 Walker A/P-loop; other site 648999014182 ATP binding site [chemical binding]; other site 648999014183 Q-loop/lid; other site 648999014184 ABC transporter signature motif; other site 648999014185 Walker B; other site 648999014186 D-loop; other site 648999014187 H-loop/switch region; other site 648999014188 Beta propeller domain; Region: Beta_propel; pfam09826 648999014189 Ubiquitin-like proteins; Region: UBQ; cl00155 648999014190 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 648999014191 Protein of unknown function (DUF419); Region: DUF419; cl15265 648999014192 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 648999014193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 648999014194 Coenzyme A binding pocket [chemical binding]; other site 648999014195 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999014196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999014197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999014198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999014199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999014200 active site 648999014201 catalytic tetrad [active] 648999014202 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 648999014203 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 648999014204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 648999014205 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 648999014206 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 648999014207 FAD binding domain; Region: FAD_binding_4; pfam01565 648999014208 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 648999014209 Predicted integral membrane protein [Function unknown]; Region: COG5660 648999014210 Putative zinc-finger; Region: zf-HC2; pfam13490 648999014211 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 648999014212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999014213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999014214 DNA binding residues [nucleotide binding] 648999014215 MOSC domain; Region: MOSC; pfam03473 648999014216 Uncharacterized conserved protein [Function unknown]; Region: COG1432 648999014217 LabA_like proteins; Region: LabA_like; cd06167 648999014218 putative metal binding site [ion binding]; other site 648999014219 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 648999014220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014221 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 648999014222 putative substrate translocation pore; other site 648999014223 Domain of unknown function (DUF305); Region: DUF305; pfam03713 648999014224 Chitin binding domain; Region: Chitin_bind_3; pfam03067 648999014225 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 648999014226 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999014227 Interdomain contacts; other site 648999014228 Cytokine receptor motif; other site 648999014229 Cellulose binding domain; Region: CBM_2; pfam00553 648999014230 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 648999014231 active site 648999014232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999014234 putative substrate translocation pore; other site 648999014235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014236 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 648999014237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999014238 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 648999014239 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 648999014240 putative hydrophobic ligand binding site [chemical binding]; other site 648999014241 CBD_II domain; Region: CBD_II; smart00637 648999014242 Cellulose binding domain; Region: CBM_2; pfam00553 648999014243 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 648999014244 active site 648999014245 Cellulose binding domain; Region: CBM_2; pfam00553 648999014246 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 648999014247 Amb_all domain; Region: Amb_all; smart00656 648999014248 EamA-like transporter family; Region: EamA; pfam00892 648999014249 EamA-like transporter family; Region: EamA; pfam00892 648999014250 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999014251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999014252 DNA-binding site [nucleotide binding]; DNA binding site 648999014253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999014254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999014255 homodimer interface [polypeptide binding]; other site 648999014256 catalytic residue [active] 648999014257 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999014258 sugar binding site [chemical binding]; other site 648999014259 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999014260 sugar binding site [chemical binding]; other site 648999014261 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 648999014262 Interdomain contacts; other site 648999014263 CARDB; Region: CARDB; pfam07705 648999014264 CARDB; Region: CARDB; pfam07705 648999014265 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 648999014266 putative metal binding site [ion binding]; other site 648999014267 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 648999014268 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 648999014269 putative metal binding site [ion binding]; other site 648999014270 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 648999014271 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999014272 sugar binding site [chemical binding]; other site 648999014273 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 648999014274 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 648999014275 sugar binding site [chemical binding]; other site 648999014276 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 648999014277 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 648999014278 active site 648999014279 catalytic site [active] 648999014280 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 648999014281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999014282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014283 dimer interface [polypeptide binding]; other site 648999014284 conserved gate region; other site 648999014285 putative PBP binding loops; other site 648999014286 ABC-ATPase subunit interface; other site 648999014287 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 648999014288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014289 dimer interface [polypeptide binding]; other site 648999014290 conserved gate region; other site 648999014291 putative PBP binding loops; other site 648999014292 ABC-ATPase subunit interface; other site 648999014293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999014294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 648999014295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999014296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999014297 DNA binding site [nucleotide binding] 648999014298 domain linker motif; other site 648999014299 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 648999014300 putative dimerization interface [polypeptide binding]; other site 648999014301 putative ligand binding site [chemical binding]; other site 648999014302 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 648999014303 putative metal binding site [ion binding]; other site 648999014304 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 648999014305 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 648999014306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999014307 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999014308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999014309 DNA binding residues [nucleotide binding] 648999014310 Sporulation and spore germination; Region: Germane; pfam10646 648999014311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999014312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014313 active site 648999014314 phosphorylation site [posttranslational modification] 648999014315 intermolecular recognition site; other site 648999014316 dimerization interface [polypeptide binding]; other site 648999014317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999014318 DNA binding site [nucleotide binding] 648999014319 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014320 anti sigma factor interaction site; other site 648999014321 regulatory phosphorylation site [posttranslational modification]; other site 648999014322 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014323 anti sigma factor interaction site; other site 648999014324 regulatory phosphorylation site [posttranslational modification]; other site 648999014325 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 648999014326 Cellulose binding domain; Region: CBM_2; pfam00553 648999014327 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 648999014328 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 648999014329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999014330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999014331 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 648999014332 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 648999014333 Ligand binding site; other site 648999014334 Putative Catalytic site; other site 648999014335 DXD motif; other site 648999014336 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 648999014337 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 648999014338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999014339 Cellulose binding domain; Region: CBM_2; pfam00553 648999014340 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 648999014341 5'-3' exonuclease; Region: 53EXOc; smart00475 648999014342 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 648999014343 active site 648999014344 metal binding site 1 [ion binding]; metal-binding site 648999014345 putative 5' ssDNA interaction site; other site 648999014346 metal binding site 3; metal-binding site 648999014347 metal binding site 2 [ion binding]; metal-binding site 648999014348 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 648999014349 putative DNA binding site [nucleotide binding]; other site 648999014350 putative metal binding site [ion binding]; other site 648999014351 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 648999014352 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 648999014353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999014354 ATP binding site [chemical binding]; other site 648999014355 putative Mg++ binding site [ion binding]; other site 648999014356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 648999014357 nucleotide binding region [chemical binding]; other site 648999014358 ATP-binding site [chemical binding]; other site 648999014359 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 648999014360 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 648999014361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999014362 motif II; other site 648999014363 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 648999014364 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 648999014365 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 648999014366 Fasciclin domain; Region: Fasciclin; cl02663 648999014367 MG2 domain; Region: A2M_N; pfam01835 648999014368 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 648999014369 intersubunit interface [polypeptide binding]; other site 648999014370 Transposase; Region: DEDD_Tnp_IS110; pfam01548 648999014371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 648999014372 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 648999014373 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 648999014374 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 648999014375 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 648999014376 Predicted transcriptional regulator [Transcription]; Region: COG2378 648999014377 WYL domain; Region: WYL; pfam13280 648999014378 Cation efflux family; Region: Cation_efflux; pfam01545 648999014379 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 648999014380 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 648999014381 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 648999014382 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 648999014383 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 648999014384 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 648999014385 active site 648999014386 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 648999014387 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 648999014388 active site 648999014389 Pup-like protein; Region: Pup; pfam05639 648999014390 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 648999014391 proteasome ATPase; Region: pup_AAA; TIGR03689 648999014392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999014393 Walker A motif; other site 648999014394 ATP binding site [chemical binding]; other site 648999014395 Walker B motif; other site 648999014396 arginine finger; other site 648999014397 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 648999014398 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 648999014399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014400 S-adenosylmethionine binding site [chemical binding]; other site 648999014401 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 648999014402 active site 648999014403 Peptidase family M50; Region: Peptidase_M50; pfam02163 648999014404 putative substrate binding region [chemical binding]; other site 648999014405 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 648999014406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999014407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014408 active site 648999014409 phosphorylation site [posttranslational modification] 648999014410 intermolecular recognition site; other site 648999014411 dimerization interface [polypeptide binding]; other site 648999014412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999014413 DNA binding residues [nucleotide binding] 648999014414 dimerization interface [polypeptide binding]; other site 648999014415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 648999014416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 648999014417 Walker A/P-loop; other site 648999014418 ATP binding site [chemical binding]; other site 648999014419 Q-loop/lid; other site 648999014420 ABC transporter signature motif; other site 648999014421 Walker B; other site 648999014422 D-loop; other site 648999014423 H-loop/switch region; other site 648999014424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999014425 FtsX-like permease family; Region: FtsX; pfam02687 648999014426 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 648999014427 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 648999014428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999014429 motif II; other site 648999014430 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 648999014431 Cation efflux family; Region: Cation_efflux; cl00316 648999014432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999014433 dimerization interface [polypeptide binding]; other site 648999014434 putative DNA binding site [nucleotide binding]; other site 648999014435 putative Zn2+ binding site [ion binding]; other site 648999014436 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 648999014437 DNA binding residues [nucleotide binding] 648999014438 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 648999014439 dimer interface [polypeptide binding]; other site 648999014440 mercury binding site [ion binding]; other site 648999014441 hypothetical protein; Provisional; Region: PRK02237 648999014442 RNA polymerase factor sigma-70; Validated; Region: PRK08241 648999014443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999014444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999014445 DNA binding residues [nucleotide binding] 648999014446 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999014447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999014448 DNA-binding site [nucleotide binding]; DNA binding site 648999014449 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 648999014450 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 648999014451 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 648999014452 substrate binding pocket [chemical binding]; other site 648999014453 dimer interface [polypeptide binding]; other site 648999014454 inhibitor binding site; inhibition site 648999014455 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 648999014456 B12 binding site [chemical binding]; other site 648999014457 cobalt ligand [ion binding]; other site 648999014458 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 648999014459 PAC2 family; Region: PAC2; pfam09754 648999014460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999014461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999014462 DNA-binding site [nucleotide binding]; DNA binding site 648999014463 UTRA domain; Region: UTRA; pfam07702 648999014464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999014465 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 648999014466 active site 648999014467 HIGH motif; other site 648999014468 nucleotide binding site [chemical binding]; other site 648999014469 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 648999014470 active site 648999014471 KMSKS motif; other site 648999014472 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 648999014473 tRNA binding surface [nucleotide binding]; other site 648999014474 anticodon binding site; other site 648999014475 conserved hypothetical protein; Region: TIGR03843 648999014476 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 648999014477 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 648999014478 catalytic core [active] 648999014479 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 648999014480 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 648999014481 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 648999014482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 648999014483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 648999014484 active site 648999014485 catalytic tetrad [active] 648999014486 hypothetical protein; Provisional; Region: PRK07906 648999014487 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 648999014488 putative metal binding site [ion binding]; other site 648999014489 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 648999014490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999014491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999014492 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 648999014493 substrate binding pocket [chemical binding]; other site 648999014494 dimerization interface [polypeptide binding]; other site 648999014495 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 648999014496 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 648999014497 Clp amino terminal domain; Region: Clp_N; pfam02861 648999014498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999014499 Walker A motif; other site 648999014500 ATP binding site [chemical binding]; other site 648999014501 Walker B motif; other site 648999014502 arginine finger; other site 648999014503 UvrB/uvrC motif; Region: UVR; pfam02151 648999014504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999014505 Walker A motif; other site 648999014506 ATP binding site [chemical binding]; other site 648999014507 Walker B motif; other site 648999014508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 648999014509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999014510 Cupin superfamily protein; Region: Cupin_4; pfam08007 648999014511 Cupin-like domain; Region: Cupin_8; pfam13621 648999014512 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 648999014513 Protein of unknown function DUF72; Region: DUF72; cl00777 648999014514 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 648999014515 Protein of unknown function DUF72; Region: DUF72; pfam01904 648999014516 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 648999014517 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 648999014518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999014519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999014520 DNA binding site [nucleotide binding] 648999014521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999014522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999014523 DNA binding site [nucleotide binding] 648999014524 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 648999014525 active site residue [active] 648999014526 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 648999014527 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 648999014528 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 648999014529 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 648999014530 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 648999014531 Methyltransferase domain; Region: Methyltransf_11; pfam08241 648999014532 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 648999014533 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 648999014534 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 648999014535 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 648999014536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 648999014537 nucleotide binding region [chemical binding]; other site 648999014538 ATP-binding site [chemical binding]; other site 648999014539 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 648999014540 putative NAD(P) binding site [chemical binding]; other site 648999014541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 648999014542 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999014543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999014544 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 648999014545 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 648999014546 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 648999014547 Ligand binding site; other site 648999014548 Putative Catalytic site; other site 648999014549 DXD motif; other site 648999014550 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 648999014551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999014552 putative ADP-binding pocket [chemical binding]; other site 648999014553 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014554 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999014555 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 648999014556 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 648999014557 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 648999014558 D-pathway; other site 648999014559 Putative ubiquinol binding site [chemical binding]; other site 648999014560 Low-spin heme (heme b) binding site [chemical binding]; other site 648999014561 Putative water exit pathway; other site 648999014562 Binuclear center (heme o3/CuB) [ion binding]; other site 648999014563 K-pathway; other site 648999014564 Putative proton exit pathway; other site 648999014565 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 648999014566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999014567 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 648999014568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999014569 DNA binding residues [nucleotide binding] 648999014570 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 648999014571 thiamine pyrophosphate protein; Provisional; Region: PRK08273 648999014572 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 648999014573 PYR/PP interface [polypeptide binding]; other site 648999014574 dimer interface [polypeptide binding]; other site 648999014575 TPP binding site [chemical binding]; other site 648999014576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 648999014577 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 648999014578 TPP-binding site [chemical binding]; other site 648999014579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999014580 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 648999014581 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 648999014582 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 648999014583 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 648999014584 active site 648999014585 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 648999014586 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 648999014587 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999014588 DNA binding site [nucleotide binding] 648999014589 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999014590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999014591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999014592 binding surface 648999014593 TPR motif; other site 648999014594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999014595 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 648999014596 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 648999014597 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 648999014598 catalytic site [active] 648999014599 active site 648999014600 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 648999014601 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 648999014602 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 648999014603 active site 648999014604 catalytic site [active] 648999014605 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 648999014606 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 648999014607 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 648999014608 active site 648999014609 catalytic site [active] 648999014610 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 648999014611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999014612 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 648999014613 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 648999014614 dimer interface [polypeptide binding]; other site 648999014615 active site 648999014616 citrylCoA binding site [chemical binding]; other site 648999014617 NADH binding [chemical binding]; other site 648999014618 cationic pore residues; other site 648999014619 oxalacetate/citrate binding site [chemical binding]; other site 648999014620 coenzyme A binding site [chemical binding]; other site 648999014621 catalytic triad [active] 648999014622 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 648999014623 Sulfatase; Region: Sulfatase; cl17466 648999014624 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 648999014625 dimer interface [polypeptide binding]; other site 648999014626 ligand binding site [chemical binding]; other site 648999014627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999014628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999014629 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 648999014630 Ligand binding site; other site 648999014631 Ligand binding site; other site 648999014632 Ligand binding site; other site 648999014633 Putative Catalytic site; other site 648999014634 DXD motif; other site 648999014635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 648999014636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 648999014637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999014638 dimer interface [polypeptide binding]; other site 648999014639 phosphorylation site [posttranslational modification] 648999014640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999014641 ATP binding site [chemical binding]; other site 648999014642 Mg2+ binding site [ion binding]; other site 648999014643 G-X-G motif; other site 648999014644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999014645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014646 active site 648999014647 phosphorylation site [posttranslational modification] 648999014648 intermolecular recognition site; other site 648999014649 dimerization interface [polypeptide binding]; other site 648999014650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999014651 DNA binding site [nucleotide binding] 648999014652 short chain dehydrogenase; Provisional; Region: PRK05872 648999014653 classical (c) SDRs; Region: SDR_c; cd05233 648999014654 NAD(P) binding site [chemical binding]; other site 648999014655 active site 648999014656 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 648999014657 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999014658 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999014659 active site 648999014660 ATP binding site [chemical binding]; other site 648999014661 substrate binding site [chemical binding]; other site 648999014662 activation loop (A-loop); other site 648999014663 OsmC-like protein; Region: OsmC; cl00767 648999014664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999014665 putative catalytic site [active] 648999014666 putative metal binding site [ion binding]; other site 648999014667 putative phosphate binding site [ion binding]; other site 648999014668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 648999014669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999014670 active site 648999014671 phosphorylation site [posttranslational modification] 648999014672 intermolecular recognition site; other site 648999014673 dimerization interface [polypeptide binding]; other site 648999014674 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014675 anti sigma factor interaction site; other site 648999014676 regulatory phosphorylation site [posttranslational modification]; other site 648999014677 B12 binding domain; Region: B12-binding_2; pfam02607 648999014678 B12 binding domain; Region: B12-binding; pfam02310 648999014679 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 648999014680 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014681 anti sigma factor interaction site; other site 648999014682 regulatory phosphorylation site [posttranslational modification]; other site 648999014683 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 648999014684 anti sigma factor interaction site; other site 648999014685 regulatory phosphorylation site [posttranslational modification]; other site 648999014686 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 648999014687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999014688 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 648999014689 putative metal binding site [ion binding]; other site 648999014690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 648999014691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999014692 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 648999014693 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999014694 active site 648999014695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999014696 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 648999014697 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 648999014698 FAD binding pocket [chemical binding]; other site 648999014699 FAD binding motif [chemical binding]; other site 648999014700 phosphate binding motif [ion binding]; other site 648999014701 beta-alpha-beta structure motif; other site 648999014702 NAD binding pocket [chemical binding]; other site 648999014703 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 648999014704 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 648999014705 Moco binding site; other site 648999014706 metal coordination site [ion binding]; other site 648999014707 Integral membrane protein TerC family; Region: TerC; cl10468 648999014708 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 648999014709 CoA-transferase family III; Region: CoA_transf_3; pfam02515 648999014710 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 648999014711 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 648999014712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 648999014713 Pirin-related protein [General function prediction only]; Region: COG1741 648999014714 Pirin; Region: Pirin; pfam02678 648999014715 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 648999014716 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 648999014717 homodimer interface [polypeptide binding]; other site 648999014718 metal binding site [ion binding]; metal-binding site 648999014719 glutamate dehydrogenase; Provisional; Region: PRK09414 648999014720 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 648999014721 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 648999014722 NAD(P) binding pocket [chemical binding]; other site 648999014723 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 648999014724 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 648999014725 Predicted amidohydrolase [General function prediction only]; Region: COG0388 648999014726 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 648999014727 active site 648999014728 catalytic triad [active] 648999014729 dimer interface [polypeptide binding]; other site 648999014730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 648999014731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999014732 active site 648999014733 ATP binding site [chemical binding]; other site 648999014734 substrate binding site [chemical binding]; other site 648999014735 activation loop (A-loop); other site 648999014736 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 648999014737 Helix-turn-helix domain; Region: HTH_31; pfam13560 648999014738 Domain of unknown function (DUF397); Region: DUF397; pfam04149 648999014739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999014740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999014741 metal binding site [ion binding]; metal-binding site 648999014742 active site 648999014743 I-site; other site 648999014744 PemK-like protein; Region: PemK; pfam02452 648999014745 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 648999014746 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999014747 nudix motif; other site 648999014748 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 648999014749 Condensation domain; Region: Condensation; pfam00668 648999014750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999014751 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 648999014752 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999014753 acyl-activating enzyme (AAE) consensus motif; other site 648999014754 AMP binding site [chemical binding]; other site 648999014755 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014756 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 648999014757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014758 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999014759 putative substrate translocation pore; other site 648999014760 Condensation domain; Region: Condensation; pfam00668 648999014761 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 648999014762 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999014763 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999014764 acyl-activating enzyme (AAE) consensus motif; other site 648999014765 AMP binding site [chemical binding]; other site 648999014766 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014767 MbtH-like protein; Region: MbtH; cl01279 648999014768 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 648999014769 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999014770 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999014771 active site 648999014772 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999014773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999014774 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 648999014775 putative NADP binding site [chemical binding]; other site 648999014776 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999014777 active site 648999014778 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999014779 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014780 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999014781 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999014782 acyl-activating enzyme (AAE) consensus motif; other site 648999014783 AMP binding site [chemical binding]; other site 648999014784 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014785 Condensation domain; Region: Condensation; pfam00668 648999014786 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999014787 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 648999014788 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014789 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 648999014790 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 648999014791 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 648999014792 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 648999014793 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999014794 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999014795 acyl-activating enzyme (AAE) consensus motif; other site 648999014796 AMP binding site [chemical binding]; other site 648999014797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999014798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999014799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999014800 active site 648999014801 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 648999014802 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 648999014803 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 648999014804 putative [4Fe-4S] binding site [ion binding]; other site 648999014805 putative molybdopterin cofactor binding site [chemical binding]; other site 648999014806 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 648999014807 molybdopterin cofactor binding site; other site 648999014808 FOG: CBS domain [General function prediction only]; Region: COG0517 648999014809 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 648999014810 alpha-glucosidase; Provisional; Region: PRK10137 648999014811 alpha-glucosidase; Provisional; Region: PRK10137 648999014812 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 648999014813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 648999014814 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 648999014815 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 648999014816 putative NAD(P) binding site [chemical binding]; other site 648999014817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 648999014818 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 648999014819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999014820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014821 dimer interface [polypeptide binding]; other site 648999014822 conserved gate region; other site 648999014823 putative PBP binding loops; other site 648999014824 ABC-ATPase subunit interface; other site 648999014825 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 648999014826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999014827 dimer interface [polypeptide binding]; other site 648999014828 conserved gate region; other site 648999014829 putative PBP binding loops; other site 648999014830 ABC-ATPase subunit interface; other site 648999014831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014832 S-adenosylmethionine binding site [chemical binding]; other site 648999014833 Protein of unknown function (DUF690); Region: DUF690; cl04939 648999014834 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 648999014835 catalytic residues [active] 648999014836 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 648999014837 putative homotetramer interface [polypeptide binding]; other site 648999014838 putative homodimer interface [polypeptide binding]; other site 648999014839 putative allosteric switch controlling residues; other site 648999014840 putative metal binding site [ion binding]; other site 648999014841 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 648999014842 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999014843 active site residue [active] 648999014844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999014845 active site residue [active] 648999014846 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 648999014847 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 648999014848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014849 S-adenosylmethionine binding site [chemical binding]; other site 648999014850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999014851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 648999014852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999014853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999014854 acyl-activating enzyme (AAE) consensus motif; other site 648999014855 AMP binding site [chemical binding]; other site 648999014856 active site 648999014857 CoA binding site [chemical binding]; other site 648999014858 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 648999014859 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 648999014860 AAA domain; Region: AAA_33; pfam13671 648999014861 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 648999014862 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 648999014863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014864 S-adenosylmethionine binding site [chemical binding]; other site 648999014865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 648999014866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 648999014867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 648999014868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 648999014870 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 648999014871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 648999014872 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 648999014873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999014874 motif II; other site 648999014875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 648999014876 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 648999014877 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999014878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014879 S-adenosylmethionine binding site [chemical binding]; other site 648999014880 YcxB-like protein; Region: YcxB; pfam14317 648999014881 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999014882 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999014883 TAP-like protein; Region: Abhydrolase_4; pfam08386 648999014884 hypothetical protein; Provisional; Region: PRK07758 648999014885 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999014886 active site 648999014887 metal binding site [ion binding]; metal-binding site 648999014888 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 648999014889 dimer interface [polypeptide binding]; other site 648999014890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999014891 metal binding site [ion binding]; metal-binding site 648999014892 YCII-related domain; Region: YCII; cl00999 648999014893 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 648999014894 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 648999014895 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 648999014896 homodimer interaction site [polypeptide binding]; other site 648999014897 cofactor binding site; other site 648999014898 Protein of unknown function (DUF419); Region: DUF419; cl15265 648999014899 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 648999014900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999014901 NAD(P) binding site [chemical binding]; other site 648999014902 active site 648999014903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 648999014904 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 648999014905 SnoaL-like domain; Region: SnoaL_2; pfam12680 648999014906 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 648999014907 conserved cys residue [active] 648999014908 Membrane transport protein; Region: Mem_trans; cl09117 648999014909 Membrane transport protein; Region: Mem_trans; cl09117 648999014910 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 648999014911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999014912 DNA-binding site [nucleotide binding]; DNA binding site 648999014913 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 648999014914 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 648999014915 DDE superfamily endonuclease; Region: DDE_4; pfam13359 648999014916 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 648999014917 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 648999014918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999014919 active site 648999014920 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 648999014921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999014922 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 648999014923 Walker A motif; other site 648999014924 ATP binding site [chemical binding]; other site 648999014925 Walker B motif; other site 648999014926 arginine finger; other site 648999014927 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 648999014928 motif 1; other site 648999014929 active site 648999014930 motif 2; other site 648999014931 motif 3; other site 648999014932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999014933 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999014934 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 648999014935 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 648999014936 putative di-iron ligands [ion binding]; other site 648999014937 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 648999014938 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 648999014939 FAD binding pocket [chemical binding]; other site 648999014940 FAD binding motif [chemical binding]; other site 648999014941 phosphate binding motif [ion binding]; other site 648999014942 beta-alpha-beta structure motif; other site 648999014943 NAD binding pocket [chemical binding]; other site 648999014944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 648999014945 catalytic loop [active] 648999014946 iron binding site [ion binding]; other site 648999014947 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999014948 hypothetical protein; Provisional; Region: PRK07877 648999014949 Transcription factor Tfb4; Region: Tfb4; cl02173 648999014950 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 648999014951 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999014952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999014953 catalytic residue [active] 648999014954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999014955 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 648999014956 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 648999014957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999014958 NAD(P) binding site [chemical binding]; other site 648999014959 active site 648999014960 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999014961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999014962 S-adenosylmethionine binding site [chemical binding]; other site 648999014963 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 648999014964 hypothetical protein; Provisional; Region: PRK07475 648999014965 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 648999014966 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 648999014967 active site 648999014968 dimer interface [polypeptide binding]; other site 648999014969 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 648999014970 Ligand Binding Site [chemical binding]; other site 648999014971 Molecular Tunnel; other site 648999014972 glutamine synthetase, type I; Region: GlnA; TIGR00653 648999014973 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 648999014974 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 648999014975 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 648999014976 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 648999014977 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 648999014978 Cellulose binding domain; Region: CBM_2; pfam00553 648999014979 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 648999014980 Cellulose binding domain; Region: CBM_2; pfam00553 648999014981 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 648999014982 substrate binding site [chemical binding]; other site 648999014983 active site 648999014984 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 648999014985 metal binding site [ion binding]; metal-binding site 648999014986 ligand binding site [chemical binding]; other site 648999014987 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 648999014988 active site 648999014989 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 648999014990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 648999014991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 648999014992 DNA binding site [nucleotide binding] 648999014993 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999014994 hypothetical protein; Provisional; Region: PRK07877 648999014995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 648999014996 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 648999014997 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 648999014998 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 648999014999 substrate binding pocket [chemical binding]; other site 648999015000 chain length determination region; other site 648999015001 substrate-Mg2+ binding site; other site 648999015002 catalytic residues [active] 648999015003 aspartate-rich region 1; other site 648999015004 active site lid residues [active] 648999015005 aspartate-rich region 2; other site 648999015006 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 648999015007 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 648999015008 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 648999015009 putative active site cavity [active] 648999015010 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999015011 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 648999015012 nucleotide binding site [chemical binding]; other site 648999015013 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 648999015014 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 648999015015 inhibitor site; inhibition site 648999015016 active site 648999015017 dimer interface [polypeptide binding]; other site 648999015018 catalytic residue [active] 648999015019 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999015020 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999015021 Walker A/P-loop; other site 648999015022 ATP binding site [chemical binding]; other site 648999015023 Q-loop/lid; other site 648999015024 ABC transporter signature motif; other site 648999015025 Walker B; other site 648999015026 D-loop; other site 648999015027 H-loop/switch region; other site 648999015028 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999015029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 648999015030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999015031 dimer interface [polypeptide binding]; other site 648999015032 conserved gate region; other site 648999015033 putative PBP binding loops; other site 648999015034 ABC-ATPase subunit interface; other site 648999015035 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 648999015036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 648999015037 Walker A/P-loop; other site 648999015038 ATP binding site [chemical binding]; other site 648999015039 Q-loop/lid; other site 648999015040 ABC transporter signature motif; other site 648999015041 Walker B; other site 648999015042 D-loop; other site 648999015043 H-loop/switch region; other site 648999015044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 648999015045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 648999015046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 648999015047 dimer interface [polypeptide binding]; other site 648999015048 conserved gate region; other site 648999015049 putative PBP binding loops; other site 648999015050 ABC-ATPase subunit interface; other site 648999015051 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 648999015052 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 648999015053 Transcriptional regulators [Transcription]; Region: FadR; COG2186 648999015054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999015055 DNA-binding site [nucleotide binding]; DNA binding site 648999015056 FCD domain; Region: FCD; pfam07729 648999015057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 648999015058 dimerization interface [polypeptide binding]; other site 648999015059 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999015060 putative DNA binding site [nucleotide binding]; other site 648999015061 putative Zn2+ binding site [ion binding]; other site 648999015062 Domain of unknown function (DUF756); Region: DUF756; pfam05506 648999015063 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 648999015064 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 648999015065 active site 648999015066 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 648999015067 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 648999015068 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 648999015069 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999015070 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 648999015071 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 648999015072 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 648999015073 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 648999015074 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 648999015075 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 648999015076 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 648999015077 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 648999015078 AAA domain; Region: AAA_17; pfam13207 648999015079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999015080 putative substrate translocation pore; other site 648999015081 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 648999015082 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 648999015083 PYR/PP interface [polypeptide binding]; other site 648999015084 dimer interface [polypeptide binding]; other site 648999015085 TPP binding site [chemical binding]; other site 648999015086 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 648999015087 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 648999015088 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 648999015089 E3 interaction surface; other site 648999015090 lipoyl attachment site [posttranslational modification]; other site 648999015091 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 648999015092 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 648999015093 tetramer interface [polypeptide binding]; other site 648999015094 TPP-binding site [chemical binding]; other site 648999015095 heterodimer interface [polypeptide binding]; other site 648999015096 phosphorylation loop region [posttranslational modification] 648999015097 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999015098 hypothetical protein; Validated; Region: PRK06840 648999015099 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 648999015100 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 648999015101 Condensation domain; Region: Condensation; pfam00668 648999015102 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999015103 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 648999015104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015105 acyl-activating enzyme (AAE) consensus motif; other site 648999015106 AMP binding site [chemical binding]; other site 648999015107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015108 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 648999015109 H+ Antiporter protein; Region: 2A0121; TIGR00900 648999015110 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015111 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015112 active site 648999015113 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015114 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015115 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 648999015116 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015117 putative NADP binding site [chemical binding]; other site 648999015118 active site 648999015119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015120 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 648999015121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015122 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015123 acyl-activating enzyme (AAE) consensus motif; other site 648999015124 AMP binding site [chemical binding]; other site 648999015125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015126 Condensation domain; Region: Condensation; pfam00668 648999015127 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999015128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 648999015129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015130 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015131 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015132 active site 648999015133 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015134 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015135 acyl-activating enzyme (AAE) consensus motif; other site 648999015136 AMP binding site [chemical binding]; other site 648999015137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015138 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 648999015139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015140 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015141 acyl-activating enzyme (AAE) consensus motif; other site 648999015142 AMP binding site [chemical binding]; other site 648999015143 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 648999015144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015146 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 648999015147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999015148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999015149 Walker A/P-loop; other site 648999015150 ATP binding site [chemical binding]; other site 648999015151 Q-loop/lid; other site 648999015152 ABC transporter signature motif; other site 648999015153 Walker B; other site 648999015154 D-loop; other site 648999015155 H-loop/switch region; other site 648999015156 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 648999015157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 648999015158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999015159 dimer interface [polypeptide binding]; other site 648999015160 phosphorylation site [posttranslational modification] 648999015161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999015162 ATP binding site [chemical binding]; other site 648999015163 Mg2+ binding site [ion binding]; other site 648999015164 G-X-G motif; other site 648999015165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999015166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999015167 active site 648999015168 phosphorylation site [posttranslational modification] 648999015169 intermolecular recognition site; other site 648999015170 dimerization interface [polypeptide binding]; other site 648999015171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999015172 DNA binding site [nucleotide binding] 648999015173 Electron transfer DM13; Region: DM13; pfam10517 648999015174 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 648999015175 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 648999015176 Protease prsW family; Region: PrsW-protease; pfam13367 648999015177 ATP cone domain; Region: ATP-cone; pfam03477 648999015178 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 648999015179 Class I ribonucleotide reductase; Region: RNR_I; cd01679 648999015180 active site 648999015181 dimer interface [polypeptide binding]; other site 648999015182 catalytic residues [active] 648999015183 effector binding site; other site 648999015184 R2 peptide binding site; other site 648999015185 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 648999015186 dimer interface [polypeptide binding]; other site 648999015187 putative radical transfer pathway; other site 648999015188 diiron center [ion binding]; other site 648999015189 tyrosyl radical; other site 648999015190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999015191 Condensation domain; Region: Condensation; pfam00668 648999015192 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999015193 active site 648999015194 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 648999015195 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999015196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999015197 catalytic residue [active] 648999015198 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 648999015199 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 648999015200 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 648999015201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015203 acyl-activating enzyme (AAE) consensus motif; other site 648999015204 acyl-activating enzyme (AAE) consensus motif; other site 648999015205 AMP binding site [chemical binding]; other site 648999015206 active site 648999015207 CoA binding site [chemical binding]; other site 648999015208 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 648999015209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 648999015210 dimer interface [polypeptide binding]; other site 648999015211 active site 648999015212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 648999015213 catalytic residues [active] 648999015214 substrate binding site [chemical binding]; other site 648999015215 acyl carrier protein; Provisional; Region: PRK07081 648999015216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999015217 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 648999015218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999015219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999015220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999015221 active site 648999015222 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 648999015223 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015224 acyl-activating enzyme (AAE) consensus motif; other site 648999015225 AMP binding site [chemical binding]; other site 648999015226 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 648999015227 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 648999015228 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 648999015229 active site 648999015230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999015231 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999015232 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999015233 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999015234 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999015235 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 648999015236 active site 648999015237 catalytic triad [active] 648999015238 oxyanion hole [active] 648999015239 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 648999015240 active site 648999015241 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 648999015242 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 648999015243 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 648999015244 putative metal binding site [ion binding]; other site 648999015245 Epoxide hydrolase N terminus; Region: EHN; pfam06441 648999015246 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999015247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 648999015248 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999015249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 648999015250 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 648999015251 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 648999015252 active site 648999015253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999015254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 648999015255 catalytic residue [active] 648999015256 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 648999015257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999015258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 648999015259 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 648999015260 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 648999015261 IucA / IucC family; Region: IucA_IucC; pfam04183 648999015262 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 648999015263 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 648999015264 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 648999015265 FAD binding pocket [chemical binding]; other site 648999015266 FAD binding motif [chemical binding]; other site 648999015267 phosphate binding motif [ion binding]; other site 648999015268 NAD binding pocket [chemical binding]; other site 648999015269 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 648999015270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 648999015271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 648999015272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 648999015273 ABC-ATPase subunit interface; other site 648999015274 dimer interface [polypeptide binding]; other site 648999015275 putative PBP binding regions; other site 648999015276 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 648999015277 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 648999015278 intersubunit interface [polypeptide binding]; other site 648999015279 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 648999015280 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 648999015281 Walker A/P-loop; other site 648999015282 ATP binding site [chemical binding]; other site 648999015283 Q-loop/lid; other site 648999015284 ABC transporter signature motif; other site 648999015285 Walker B; other site 648999015286 D-loop; other site 648999015287 H-loop/switch region; other site 648999015288 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999015289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999015290 DNA-binding site [nucleotide binding]; DNA binding site 648999015291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999015292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999015293 homodimer interface [polypeptide binding]; other site 648999015294 catalytic residue [active] 648999015295 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 648999015296 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 648999015297 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 648999015298 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 648999015299 glutamine binding [chemical binding]; other site 648999015300 catalytic triad [active] 648999015301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 648999015302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015303 NAD(P) binding site [chemical binding]; other site 648999015304 active site 648999015305 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 648999015306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015307 acyl-activating enzyme (AAE) consensus motif; other site 648999015308 AMP binding site [chemical binding]; other site 648999015309 active site 648999015310 CoA binding site [chemical binding]; other site 648999015311 Prephenate dehydratase; Region: PDT; pfam00800 648999015312 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 648999015313 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 648999015314 active site 648999015315 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 648999015316 B3/4 domain; Region: B3_4; pfam03483 648999015317 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 648999015318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999015319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 648999015320 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 648999015321 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 648999015322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999015323 catalytic residue [active] 648999015324 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 648999015325 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999015326 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 648999015327 Chorismate mutase type II; Region: CM_2; smart00830 648999015328 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 648999015329 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 648999015330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999015331 DNA-binding site [nucleotide binding]; DNA binding site 648999015332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999015333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999015334 homodimer interface [polypeptide binding]; other site 648999015335 catalytic residue [active] 648999015336 Cellulose binding domain; Region: CBM_2; pfam00553 648999015337 Hemerythrin-like domain; Region: Hr-like; cd12108 648999015338 Fe binding site [ion binding]; other site 648999015339 Beta-lactamase; Region: Beta-lactamase; pfam00144 648999015340 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 648999015341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999015342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999015343 active site 648999015344 phosphorylation site [posttranslational modification] 648999015345 intermolecular recognition site; other site 648999015346 dimerization interface [polypeptide binding]; other site 648999015347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999015348 DNA binding residues [nucleotide binding] 648999015349 Putative sensor; Region: Sensor; pfam13796 648999015350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 648999015351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999015352 ATP binding site [chemical binding]; other site 648999015353 Mg2+ binding site [ion binding]; other site 648999015354 G-X-G motif; other site 648999015355 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 648999015356 active site 648999015357 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 648999015358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 648999015359 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 648999015360 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999015361 putative sugar binding sites [chemical binding]; other site 648999015362 Q-X-W motif; other site 648999015363 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999015364 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999015365 putative sugar binding sites [chemical binding]; other site 648999015366 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 648999015367 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 648999015368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999015369 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 648999015370 DNA binding residues [nucleotide binding] 648999015371 elongation factor G; Reviewed; Region: PRK13351 648999015372 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 648999015373 G1 box; other site 648999015374 GTP/Mg2+ binding site [chemical binding]; other site 648999015375 G2 box; other site 648999015376 Switch I region; other site 648999015377 G3 box; other site 648999015378 Switch II region; other site 648999015379 G4 box; other site 648999015380 G5 box; other site 648999015381 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 648999015382 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 648999015383 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 648999015384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999015385 serine/threonine protein kinase; Provisional; Region: PRK14879 648999015386 Predicted integral membrane protein [Function unknown]; Region: COG0392 648999015387 short chain dehydrogenase; Provisional; Region: PRK06197 648999015388 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 648999015389 putative NAD(P) binding site [chemical binding]; other site 648999015390 active site 648999015391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999015392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999015393 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999015394 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999015395 putative sugar binding sites [chemical binding]; other site 648999015396 Q-X-W motif; other site 648999015397 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 648999015398 active site 648999015399 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 648999015400 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999015401 putative sugar binding sites [chemical binding]; other site 648999015402 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 648999015403 Q-X-W motif; other site 648999015404 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 648999015405 substrate binding site [chemical binding]; other site 648999015406 active site 648999015407 OsmC-like protein; Region: OsmC; pfam02566 648999015408 TIGR02452 family protein; Region: TIGR02452 648999015409 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 648999015410 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 648999015411 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 648999015412 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 648999015413 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 648999015414 ABC1 family; Region: ABC1; cl17513 648999015415 HEAT repeats; Region: HEAT_2; pfam13646 648999015416 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 648999015417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999015418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 648999015419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 648999015420 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 648999015421 active site 648999015422 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015424 active site 648999015425 Acyl transferase domain; Region: Acyl_transf_1; cl08282 648999015426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015427 NAD(P) binding site [chemical binding]; other site 648999015428 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015429 active site 648999015430 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015431 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 648999015432 active site 648999015433 SnoaL-like domain; Region: SnoaL_3; pfam13474 648999015434 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 648999015435 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 648999015436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 648999015437 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 648999015438 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 648999015439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999015440 S-adenosylmethionine binding site [chemical binding]; other site 648999015441 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 648999015442 structural tetrad; other site 648999015443 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 648999015444 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 648999015445 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 648999015446 FMN binding site [chemical binding]; other site 648999015447 dimer interface [polypeptide binding]; other site 648999015448 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 648999015449 hydrophobic ligand binding site; other site 648999015450 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 648999015451 putative hydrophobic ligand binding site [chemical binding]; other site 648999015452 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999015453 Transcriptional regulator PadR-like family; Region: PadR; cl17335 648999015454 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 648999015455 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 648999015456 Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733 648999015457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 648999015458 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 648999015459 active site 648999015460 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 648999015461 putative heme binding site [chemical binding]; other site 648999015462 putative substrate binding site [chemical binding]; other site 648999015463 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 648999015464 classical (c) SDRs; Region: SDR_c; cd05233 648999015465 NAD(P) binding site [chemical binding]; other site 648999015466 active site 648999015467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 648999015468 putative substrate translocation pore; other site 648999015469 Cytochrome P450; Region: p450; pfam00067 648999015470 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 648999015471 CopC domain; Region: CopC; cl01012 648999015472 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 648999015473 putative dimer interface [polypeptide binding]; other site 648999015474 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999015475 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999015476 Walker A/P-loop; other site 648999015477 ATP binding site [chemical binding]; other site 648999015478 Q-loop/lid; other site 648999015479 ABC transporter signature motif; other site 648999015480 Walker B; other site 648999015481 D-loop; other site 648999015482 H-loop/switch region; other site 648999015483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999015484 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 648999015485 active site 648999015486 motif I; other site 648999015487 motif II; other site 648999015488 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 648999015489 acyl-CoA synthetase; Validated; Region: PRK07787 648999015490 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015491 acyl-activating enzyme (AAE) consensus motif; other site 648999015492 AMP binding site [chemical binding]; other site 648999015493 active site 648999015494 CoA binding site [chemical binding]; other site 648999015495 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 648999015496 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 648999015497 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 648999015498 DNA-binding site [nucleotide binding]; DNA binding site 648999015499 RNA-binding motif; other site 648999015500 acyl-CoA synthetase; Validated; Region: PRK07787 648999015501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015503 acyl-activating enzyme (AAE) consensus motif; other site 648999015504 acyl-activating enzyme (AAE) consensus motif; other site 648999015505 AMP binding site [chemical binding]; other site 648999015506 active site 648999015507 CoA binding site [chemical binding]; other site 648999015508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 648999015509 Walker A motif; other site 648999015510 ATP binding site [chemical binding]; other site 648999015511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999015512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999015513 DNA binding residues [nucleotide binding] 648999015514 dimerization interface [polypeptide binding]; other site 648999015515 AAA ATPase domain; Region: AAA_16; pfam13191 648999015516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999015517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 648999015518 DNA binding residues [nucleotide binding] 648999015519 dimerization interface [polypeptide binding]; other site 648999015520 ABC-2 type transporter; Region: ABC2_membrane; cl17235 648999015521 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 648999015522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 648999015523 Walker A/P-loop; other site 648999015524 ATP binding site [chemical binding]; other site 648999015525 Q-loop/lid; other site 648999015526 ABC transporter signature motif; other site 648999015527 Walker B; other site 648999015528 D-loop; other site 648999015529 H-loop/switch region; other site 648999015530 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015531 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015532 active site 648999015533 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015534 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015535 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015536 NADP binding site [chemical binding]; other site 648999015537 KR domain; Region: KR; pfam08659 648999015538 active site 648999015539 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015540 Thioesterase; Region: PKS_TE; smart00824 648999015541 Erythronolide synthase docking; Region: Docking; pfam08990 648999015542 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015543 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015544 active site 648999015545 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015547 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015548 NADP binding site [chemical binding]; other site 648999015549 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015550 active site 648999015551 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015552 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015553 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015554 active site 648999015555 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015556 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015557 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015558 NADP binding site [chemical binding]; other site 648999015559 active site 648999015560 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015561 Erythronolide synthase docking; Region: Docking; pfam08990 648999015562 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015563 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015564 active site 648999015565 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015566 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015567 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015568 NADP binding site [chemical binding]; other site 648999015569 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015570 active site 648999015571 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015572 Erythronolide synthase docking; Region: Docking; pfam08990 648999015573 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015574 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015575 active site 648999015576 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015577 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015578 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015579 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015580 putative NADP binding site [chemical binding]; other site 648999015581 active site 648999015582 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015583 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015584 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015585 active site 648999015586 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015587 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015588 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015589 putative NADP binding site [chemical binding]; other site 648999015590 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015591 active site 648999015592 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015593 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015594 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015595 active site 648999015596 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015597 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015598 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015599 NADP binding site [chemical binding]; other site 648999015600 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015601 active site 648999015602 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015603 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015604 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015605 active site 648999015606 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015607 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015608 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015609 NADP binding site [chemical binding]; other site 648999015610 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015611 active site 648999015612 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015613 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015614 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015615 active site 648999015616 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015617 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015618 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015619 NADP binding site [chemical binding]; other site 648999015620 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015621 active site 648999015622 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015623 Erythronolide synthase docking; Region: Docking; pfam08990 648999015624 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015625 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015626 active site 648999015627 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015628 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015629 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015630 NADP binding site [chemical binding]; other site 648999015631 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015632 active site 648999015633 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015634 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015635 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015636 active site 648999015637 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015638 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015639 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015640 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 648999015641 Enoylreductase; Region: PKS_ER; smart00829 648999015642 NAD(P) binding site [chemical binding]; other site 648999015643 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015644 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015645 putative NADP binding site [chemical binding]; other site 648999015646 active site 648999015647 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015648 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015649 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015650 active site 648999015651 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015652 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015653 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015654 putative NADP binding site [chemical binding]; other site 648999015655 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015656 active site 648999015657 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015658 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015659 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015660 active site 648999015661 Acyl transferase domain; Region: Acyl_transf_1; cl08282 648999015662 Acyl transferase domain; Region: Acyl_transf_1; cl08282 648999015663 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015664 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015665 NADP binding site [chemical binding]; other site 648999015666 active site 648999015667 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015668 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015669 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015670 active site 648999015671 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015672 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015673 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015674 NADP binding site [chemical binding]; other site 648999015675 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015676 active site 648999015677 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015678 Erythronolide synthase docking; Region: Docking; pfam08990 648999015679 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015680 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015681 active site 648999015682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015683 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015684 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015685 NADP binding site [chemical binding]; other site 648999015686 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015687 active site 648999015688 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015689 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015690 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015691 active site 648999015692 Acyl transferase domain; Region: Acyl_transf_1; cl08282 648999015693 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015694 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015695 putative NADP binding site [chemical binding]; other site 648999015696 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015697 active site 648999015698 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015699 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015700 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015701 active site 648999015702 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015703 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015704 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015705 NADP binding site [chemical binding]; other site 648999015706 KR domain; Region: KR; pfam08659 648999015707 active site 648999015708 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015709 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015710 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015711 active site 648999015712 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015713 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015714 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015715 putative NADP binding site [chemical binding]; other site 648999015716 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015717 active site 648999015718 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015719 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015720 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015721 active site 648999015722 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015723 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015724 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015725 putative NADP binding site [chemical binding]; other site 648999015726 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015727 active site 648999015728 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015729 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015730 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015731 active site 648999015732 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015733 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015734 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015735 putative NADP binding site [chemical binding]; other site 648999015736 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015737 active site 648999015738 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015740 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015741 active site 648999015742 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015743 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015744 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015745 NADP binding site [chemical binding]; other site 648999015746 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015747 active site 648999015748 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015749 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015750 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015751 active site 648999015752 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015753 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015754 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015755 NADP binding site [chemical binding]; other site 648999015756 active site 648999015757 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015758 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015760 active site 648999015761 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015762 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015764 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 648999015765 Enoylreductase; Region: PKS_ER; smart00829 648999015766 NAD(P) binding site [chemical binding]; other site 648999015767 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015768 putative NADP binding site [chemical binding]; other site 648999015769 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015770 active site 648999015771 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015772 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015774 active site 648999015775 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015776 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015778 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 648999015779 Enoylreductase; Region: PKS_ER; smart00829 648999015780 NAD(P) binding site [chemical binding]; other site 648999015781 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015782 putative NADP binding site [chemical binding]; other site 648999015783 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015784 active site 648999015785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015786 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015788 active site 648999015789 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015790 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015791 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015792 putative NADP binding site [chemical binding]; other site 648999015793 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015794 active site 648999015795 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015796 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015797 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015798 active site 648999015799 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 648999015800 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015801 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015802 NADP binding site [chemical binding]; other site 648999015803 KR domain; Region: KR; pfam08659 648999015804 active site 648999015805 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015806 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 648999015807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999015808 active site 648999015809 metal binding site [ion binding]; metal-binding site 648999015810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 648999015811 Erythronolide synthase docking; Region: Docking; pfam08990 648999015812 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015813 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015814 active site 648999015815 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015816 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015817 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015818 putative NADP binding site [chemical binding]; other site 648999015819 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015820 active site 648999015821 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015823 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 648999015824 active site 648999015825 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015826 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 648999015827 NADP binding site [chemical binding]; other site 648999015828 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015829 active site 648999015830 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015831 Erythronolide synthase docking; Region: Docking; pfam08990 648999015832 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015833 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015834 active site 648999015835 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015836 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015837 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015838 putative NADP binding site [chemical binding]; other site 648999015839 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015840 active site 648999015841 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015842 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 648999015843 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999015844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999015845 S-adenosylmethionine binding site [chemical binding]; other site 648999015846 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 648999015847 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999015848 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999015849 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999015850 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 648999015851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 648999015852 acyl-activating enzyme (AAE) consensus motif; other site 648999015853 AMP binding site [chemical binding]; other site 648999015854 active site 648999015855 CoA binding site [chemical binding]; other site 648999015856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015857 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015858 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015859 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015860 active site 648999015861 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015862 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015863 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015864 putative NADP binding site [chemical binding]; other site 648999015865 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015866 active site 648999015867 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015868 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 648999015869 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 648999015870 active site 648999015871 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 648999015872 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 648999015873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015874 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 648999015875 Enoylreductase; Region: PKS_ER; smart00829 648999015876 NAD(P) binding site [chemical binding]; other site 648999015877 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 648999015878 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 648999015879 putative NADP binding site [chemical binding]; other site 648999015880 active site 648999015881 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 648999015882 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 648999015883 dimer interface [polypeptide binding]; other site 648999015884 active site 648999015885 metal binding site [ion binding]; metal-binding site 648999015886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999015887 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015888 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015889 acyl-activating enzyme (AAE) consensus motif; other site 648999015890 AMP binding site [chemical binding]; other site 648999015891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 648999015892 Condensation domain; Region: Condensation; pfam00668 648999015893 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 648999015894 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 648999015895 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 648999015896 acyl-activating enzyme (AAE) consensus motif; other site 648999015897 AMP binding site [chemical binding]; other site 648999015898 Condensation domain; Region: Condensation; pfam00668 648999015899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999015900 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 648999015901 active site 648999015902 motif I; other site 648999015903 motif II; other site 648999015904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 648999015905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 648999015906 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 648999015907 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 648999015908 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 648999015909 inhibitor-cofactor binding pocket; inhibition site 648999015910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999015911 catalytic residue [active] 648999015912 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 648999015913 Dehydroquinase class II; Region: DHquinase_II; pfam01220 648999015914 active site 648999015915 trimer interface [polypeptide binding]; other site 648999015916 dimer interface [polypeptide binding]; other site 648999015917 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 648999015918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999015919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999015920 Predicted flavoprotein [General function prediction only]; Region: COG0431 648999015921 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 648999015922 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 648999015923 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 648999015924 homodimer interface [polypeptide binding]; other site 648999015925 active site 648999015926 TDP-binding site; other site 648999015927 acceptor substrate-binding pocket; other site 648999015928 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 648999015929 active site 648999015930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 648999015931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999015932 hypothetical protein; Provisional; Region: PRK06834 648999015933 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 648999015934 DDE superfamily endonuclease; Region: DDE_5; cl17874 648999015935 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 648999015936 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 648999015937 acyl-activating enzyme (AAE) consensus motif; other site 648999015938 putative AMP binding site [chemical binding]; other site 648999015939 putative active site [active] 648999015940 putative CoA binding site [chemical binding]; other site 648999015941 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 648999015942 putative active site [active] 648999015943 putative catalytic site [active] 648999015944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999015945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999015946 active site 648999015947 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 648999015948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 648999015949 NAD(P) binding site [chemical binding]; other site 648999015950 active site 648999015951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 648999015952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 648999015953 active site 648999015954 tetracycline repressor protein TetR; Provisional; Region: PRK13756 648999015955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 648999015956 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 648999015957 Transposase, Mutator family; Region: Transposase_mut; pfam00872 648999015958 Family description; Region: VCBS; pfam13517 648999015959 Family description; Region: VCBS; pfam13517 648999015960 Family description; Region: VCBS; pfam13517 648999015961 Family description; Region: VCBS; pfam13517 648999015962 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 648999015963 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 648999015964 RHS Repeat; Region: RHS_repeat; pfam05593 648999015965 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 648999015966 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 648999015967 HYR domain; Region: HYR; pfam02494 648999015968 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999015969 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999015970 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999015971 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999015972 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999015973 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999015974 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999015975 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 648999015976 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 648999015977 HEAT repeats; Region: HEAT_2; pfam13646 648999015978 HEAT repeats; Region: HEAT_2; pfam13646 648999015979 TIR domain; Region: TIR_2; pfam13676 648999015980 FOG: WD40 repeat [General function prediction only]; Region: COG2319 648999015981 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 648999015982 structural tetrad; other site 648999015983 FOG: WD40 repeat [General function prediction only]; Region: COG2319 648999015984 flagellar assembly protein J; Reviewed; Region: PRK06041 648999015985 Caspase domain; Region: Peptidase_C14; pfam00656 648999015986 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 648999015987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999015988 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 648999015989 DNA binding residues [nucleotide binding] 648999015990 dimerization interface [polypeptide binding]; other site 648999015991 Protein kinase domain; Region: Pkinase; pfam00069 648999015992 Catalytic domain of Protein Kinases; Region: PKc; cd00180 648999015993 active site 648999015994 ATP binding site [chemical binding]; other site 648999015995 substrate binding site [chemical binding]; other site 648999015996 activation loop (A-loop); other site 648999015997 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 648999015998 PLD-like domain; Region: PLDc_2; pfam13091 648999015999 homodimer interface [polypeptide binding]; other site 648999016000 putative active site [active] 648999016001 catalytic site [active] 648999016002 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 648999016003 putative active site [active] 648999016004 catalytic site [active] 648999016005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016007 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 648999016008 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 648999016009 putative catalytic site [active] 648999016010 putative metal binding site [ion binding]; other site 648999016011 putative phosphate binding site [ion binding]; other site 648999016012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999016013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999016014 non-specific DNA binding site [nucleotide binding]; other site 648999016015 salt bridge; other site 648999016016 sequence-specific DNA binding site [nucleotide binding]; other site 648999016017 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 648999016018 Phosphotransferase enzyme family; Region: APH; pfam01636 648999016019 HD domain; Region: HD_4; pfam13328 648999016020 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 648999016021 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 648999016022 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 648999016023 Uncharacterized conserved protein [Function unknown]; Region: COG4278 648999016024 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 648999016025 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 648999016026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999016027 S-adenosylmethionine binding site [chemical binding]; other site 648999016028 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 648999016029 HsdM N-terminal domain; Region: HsdM_N; pfam12161 648999016030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 648999016031 AIPR protein; Region: AIPR; pfam10592 648999016032 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 648999016033 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 648999016034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 648999016035 ATP binding site [chemical binding]; other site 648999016036 putative Mg++ binding site [ion binding]; other site 648999016037 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 648999016038 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 648999016039 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 648999016040 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 648999016041 HsdM N-terminal domain; Region: HsdM_N; pfam12161 648999016042 Methyltransferase domain; Region: Methyltransf_26; pfam13659 648999016043 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999016044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999016045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999016046 metal binding site [ion binding]; metal-binding site 648999016047 active site 648999016048 I-site; other site 648999016049 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 648999016050 DNA methylase; Region: N6_N4_Mtase; pfam01555 648999016051 Methyltransferase domain; Region: Methyltransf_26; pfam13659 648999016052 AAA-like domain; Region: AAA_10; pfam12846 648999016053 Domain of unknown function DUF87; Region: DUF87; pfam01935 648999016054 AAA-like domain; Region: AAA_10; pfam12846 648999016055 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999016056 Walker B motif; other site 648999016057 Replication-relaxation; Region: Replic_Relax; pfam13814 648999016058 Transcriptional regulators [Transcription]; Region: MarR; COG1846 648999016059 Helix-turn-helix domain; Region: HTH_36; pfam13730 648999016060 Domain of unknown function (DUF932); Region: DUF932; pfam06067 648999016061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 648999016062 NlpC/P60 family; Region: NLPC_P60; pfam00877 648999016063 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 648999016064 HEAT repeats; Region: HEAT_2; pfam13646 648999016065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 648999016066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 648999016067 Helix-turn-helix domain; Region: HTH_17; pfam12728 648999016068 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 648999016069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999016070 active site 648999016071 DNA binding site [nucleotide binding] 648999016072 Int/Topo IB signature motif; other site 648999016073 GTP-binding protein Der; Reviewed; Region: PRK03003 648999016074 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 648999016075 G1 box; other site 648999016076 GTP/Mg2+ binding site [chemical binding]; other site 648999016077 Switch I region; other site 648999016078 G2 box; other site 648999016079 Switch II region; other site 648999016080 G3 box; other site 648999016081 G4 box; other site 648999016082 G5 box; other site 648999016083 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 648999016084 G1 box; other site 648999016085 GTP/Mg2+ binding site [chemical binding]; other site 648999016086 Switch I region; other site 648999016087 G2 box; other site 648999016088 G3 box; other site 648999016089 Switch II region; other site 648999016090 G4 box; other site 648999016091 G5 box; other site 648999016092 cytidylate kinase; Provisional; Region: cmk; PRK00023 648999016093 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 648999016094 CMP-binding site; other site 648999016095 The sites determining sugar specificity; other site 648999016096 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 648999016097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 648999016098 RNA binding surface [nucleotide binding]; other site 648999016099 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 648999016100 active site 648999016101 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 648999016102 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 648999016103 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 648999016104 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 648999016105 P-loop; other site 648999016106 Magnesium ion binding site [ion binding]; other site 648999016107 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 648999016108 Magnesium ion binding site [ion binding]; other site 648999016109 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 648999016110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999016111 active site 648999016112 DNA binding site [nucleotide binding] 648999016113 Int/Topo IB signature motif; other site 648999016114 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 648999016115 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 648999016116 hexamer interface [polypeptide binding]; other site 648999016117 ligand binding site [chemical binding]; other site 648999016118 putative active site [active] 648999016119 NAD(P) binding site [chemical binding]; other site 648999016120 TM2 domain; Region: TM2; pfam05154 648999016121 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 648999016122 dimer interface [polypeptide binding]; other site 648999016123 active site 648999016124 ADP-ribose binding site [chemical binding]; other site 648999016125 nudix motif; other site 648999016126 metal binding site [ion binding]; metal-binding site 648999016127 CTP synthetase; Validated; Region: pyrG; PRK05380 648999016128 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 648999016129 Catalytic site [active] 648999016130 active site 648999016131 UTP binding site [chemical binding]; other site 648999016132 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 648999016133 active site 648999016134 putative oxyanion hole; other site 648999016135 catalytic triad [active] 648999016136 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 648999016137 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999016138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999016139 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 648999016140 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 648999016141 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 648999016142 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 648999016143 Thiamine pyrophosphokinase; Region: TPK; cl08415 648999016144 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 648999016145 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 648999016146 Walker A/P-loop; other site 648999016147 ATP binding site [chemical binding]; other site 648999016148 Q-loop/lid; other site 648999016149 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 648999016150 ABC transporter signature motif; other site 648999016151 Walker B; other site 648999016152 D-loop; other site 648999016153 H-loop/switch region; other site 648999016154 Predicted transcriptional regulators [Transcription]; Region: COG1378 648999016155 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 648999016156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 648999016157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 648999016158 dimerization interface [polypeptide binding]; other site 648999016159 DNA binding residues [nucleotide binding] 648999016160 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 648999016161 active site 648999016162 catalytic residues [active] 648999016163 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 648999016164 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 648999016165 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 648999016166 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 648999016167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 648999016168 RNA binding surface [nucleotide binding]; other site 648999016169 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 648999016170 SCP-2 sterol transfer family; Region: SCP2; pfam02036 648999016171 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 648999016172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999016173 active site 648999016174 motif I; other site 648999016175 motif II; other site 648999016176 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 648999016177 PRC-barrel domain; Region: PRC; pfam05239 648999016178 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 648999016179 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 648999016180 active site 648999016181 HIGH motif; other site 648999016182 dimer interface [polypeptide binding]; other site 648999016183 KMSKS motif; other site 648999016184 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 648999016185 arginine-tRNA ligase; Region: PLN02286 648999016186 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 648999016187 active site 648999016188 HIGH motif; other site 648999016189 KMSK motif region; other site 648999016190 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 648999016191 tRNA binding surface [nucleotide binding]; other site 648999016192 anticodon binding site; other site 648999016193 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999016194 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 648999016195 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 648999016196 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 648999016197 putative sugar binding sites [chemical binding]; other site 648999016198 Q-X-W motif; other site 648999016199 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 648999016200 active site 648999016201 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 648999016202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999016203 FeS/SAM binding site; other site 648999016204 HEXXH motif domain; Region: mod_HExxH; TIGR04267 648999016205 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 648999016206 TIR domain; Region: TIR_2; pfam13676 648999016207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 648999016208 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 648999016209 P-loop; other site 648999016210 Magnesium ion binding site [ion binding]; other site 648999016211 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 648999016212 AAA ATPase domain; Region: AAA_16; pfam13191 648999016213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016214 Tetratricopeptide repeat; Region: TPR_10; pfam13374 648999016215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016216 Tetratricopeptide repeat; Region: TPR_10; pfam13374 648999016217 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016218 Tetratricopeptide repeat; Region: TPR_10; pfam13374 648999016219 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016220 Tetratricopeptide repeat; Region: TPR_10; pfam13374 648999016221 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 648999016222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 648999016223 Walker A motif; other site 648999016224 ATP binding site [chemical binding]; other site 648999016225 Walker B motif; other site 648999016226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999016227 Methyltransferase domain; Region: Methyltransf_31; pfam13847 648999016228 S-adenosylmethionine binding site [chemical binding]; other site 648999016229 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 648999016230 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 648999016231 homodimer interface [polypeptide binding]; other site 648999016232 homotetramer interface [polypeptide binding]; other site 648999016233 active site pocket [active] 648999016234 cleavage site 648999016235 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 648999016236 Excalibur calcium-binding domain; Region: Excalibur; smart00894 648999016237 Predicted transcriptional regulators [Transcription]; Region: COG1733 648999016238 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 648999016239 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 648999016240 homotrimer interaction site [polypeptide binding]; other site 648999016241 putative active site [active] 648999016242 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 648999016243 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 648999016244 CBD_II domain; Region: CBD_II; smart00637 648999016245 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 648999016246 additional DNA contacts [nucleotide binding]; other site 648999016247 mismatch recognition site; other site 648999016248 active site 648999016249 zinc binding site [ion binding]; other site 648999016250 DNA intercalation site [nucleotide binding]; other site 648999016251 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 648999016252 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 648999016253 cofactor binding site; other site 648999016254 DNA binding site [nucleotide binding] 648999016255 substrate interaction site [chemical binding]; other site 648999016256 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 648999016257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999016258 motif II; other site 648999016259 Predicted transcriptional regulators [Transcription]; Region: COG1725 648999016260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 648999016261 DNA-binding site [nucleotide binding]; DNA binding site 648999016262 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 648999016263 Helix-turn-helix domain; Region: HTH_17; cl17695 648999016264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 648999016265 active site 648999016266 DNA binding site [nucleotide binding] 648999016267 Int/Topo IB signature motif; other site 648999016268 CAAX protease self-immunity; Region: Abi; pfam02517 648999016269 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 648999016270 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 648999016271 heme-binding site [chemical binding]; other site 648999016272 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 648999016273 FAD binding pocket [chemical binding]; other site 648999016274 FAD binding motif [chemical binding]; other site 648999016275 phosphate binding motif [ion binding]; other site 648999016276 beta-alpha-beta structure motif; other site 648999016277 NAD binding pocket [chemical binding]; other site 648999016278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 648999016279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 648999016280 non-specific DNA binding site [nucleotide binding]; other site 648999016281 salt bridge; other site 648999016282 sequence-specific DNA binding site [nucleotide binding]; other site 648999016283 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 648999016284 active site 648999016285 catalytic residues [active] 648999016286 metal binding site [ion binding]; metal-binding site 648999016287 Methyltransferase domain; Region: Methyltransf_23; pfam13489 648999016288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 648999016289 S-adenosylmethionine binding site [chemical binding]; other site 648999016290 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 648999016291 substrate binding site [chemical binding]; other site 648999016292 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 648999016293 A new structural DNA glycosylase; Region: AlkD_like; cd06561 648999016294 active site 648999016295 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 648999016296 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 648999016297 NAD(P) binding site [chemical binding]; other site 648999016298 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 648999016299 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 648999016300 DNA binding residues [nucleotide binding] 648999016301 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 648999016302 TPP-binding site [chemical binding]; other site 648999016303 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 648999016304 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 648999016305 PYR/PP interface [polypeptide binding]; other site 648999016306 dimer interface [polypeptide binding]; other site 648999016307 TPP binding site [chemical binding]; other site 648999016308 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 648999016309 Ligand binding site; other site 648999016310 Putative Catalytic site; other site 648999016311 DXD motif; other site 648999016312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999016313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999016314 dimer interface [polypeptide binding]; other site 648999016315 phosphorylation site [posttranslational modification] 648999016316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999016317 ATP binding site [chemical binding]; other site 648999016318 Mg2+ binding site [ion binding]; other site 648999016319 G-X-G motif; other site 648999016320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 648999016321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999016322 active site 648999016323 phosphorylation site [posttranslational modification] 648999016324 intermolecular recognition site; other site 648999016325 dimerization interface [polypeptide binding]; other site 648999016326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 648999016327 DNA binding site [nucleotide binding] 648999016328 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 648999016329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 648999016330 dimer interface [polypeptide binding]; other site 648999016331 active site 648999016332 Rhomboid family; Region: Rhomboid; pfam01694 648999016333 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 648999016334 active site 648999016335 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 648999016336 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 648999016337 oligomer interface [polypeptide binding]; other site 648999016338 metal binding site [ion binding]; metal-binding site 648999016339 metal binding site [ion binding]; metal-binding site 648999016340 putative Cl binding site [ion binding]; other site 648999016341 basic sphincter; other site 648999016342 hydrophobic gate; other site 648999016343 periplasmic entrance; other site 648999016344 aspartate aminotransferase; Provisional; Region: PRK05764 648999016345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999016346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999016347 homodimer interface [polypeptide binding]; other site 648999016348 catalytic residue [active] 648999016349 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 648999016350 active site 648999016351 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 648999016352 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 648999016353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 648999016354 active site 648999016355 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 648999016356 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 648999016357 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 648999016358 Chain length determinant protein; Region: Wzz; cl15801 648999016359 Chain length determinant protein; Region: Wzz; cl15801 648999016360 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 648999016361 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 648999016362 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 648999016363 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 648999016364 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 648999016365 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 648999016366 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 648999016367 FOG: CBS domain [General function prediction only]; Region: COG0517 648999016368 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 648999016369 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 648999016370 nudix motif; other site 648999016371 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 648999016372 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 648999016373 active site 648999016374 metal-binding site 648999016375 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 648999016376 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 648999016377 active site 648999016378 NAD binding site [chemical binding]; other site 648999016379 metal binding site [ion binding]; metal-binding site 648999016380 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 648999016381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 648999016382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 648999016383 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 648999016384 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 648999016385 putative DNA binding site [nucleotide binding]; other site 648999016386 catalytic residue [active] 648999016387 putative H2TH interface [polypeptide binding]; other site 648999016388 putative catalytic residues [active] 648999016389 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 648999016390 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 648999016391 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 648999016392 Bacterial sugar transferase; Region: Bac_transf; pfam02397 648999016393 Histidine kinase; Region: His_kinase; pfam06580 648999016394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999016395 ATP binding site [chemical binding]; other site 648999016396 Mg2+ binding site [ion binding]; other site 648999016397 G-X-G motif; other site 648999016398 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 648999016399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 648999016400 active site 648999016401 phosphorylation site [posttranslational modification] 648999016402 intermolecular recognition site; other site 648999016403 dimerization interface [polypeptide binding]; other site 648999016404 LytTr DNA-binding domain; Region: LytTR; smart00850 648999016405 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 648999016406 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 648999016407 Na binding site [ion binding]; other site 648999016408 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 648999016409 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 648999016410 Walker A/P-loop; other site 648999016411 ATP binding site [chemical binding]; other site 648999016412 Q-loop/lid; other site 648999016413 ABC transporter signature motif; other site 648999016414 Walker B; other site 648999016415 D-loop; other site 648999016416 H-loop/switch region; other site 648999016417 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 648999016418 Protein of unknown function, DUF485; Region: DUF485; pfam04341 648999016419 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 648999016420 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 648999016421 Na binding site [ion binding]; other site 648999016422 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 648999016423 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 648999016424 NAD binding site [chemical binding]; other site 648999016425 putative substrate binding site 2 [chemical binding]; other site 648999016426 putative substrate binding site 1 [chemical binding]; other site 648999016427 active site 648999016428 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 648999016429 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 648999016430 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 648999016431 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 648999016432 active site residue [active] 648999016433 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 648999016434 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 648999016435 active site 648999016436 catalytic site [active] 648999016437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 648999016438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 648999016439 dimer interface [polypeptide binding]; other site 648999016440 phosphorylation site [posttranslational modification] 648999016441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 648999016442 ATP binding site [chemical binding]; other site 648999016443 Mg2+ binding site [ion binding]; other site 648999016444 G-X-G motif; other site 648999016445 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 648999016446 arginine deiminase; Provisional; Region: PRK01388 648999016447 prephenate dehydratase; Provisional; Region: PRK11898 648999016448 Prephenate dehydratase; Region: PDT; pfam00800 648999016449 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 648999016450 putative L-Phe binding site [chemical binding]; other site 648999016451 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 648999016452 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 648999016453 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 648999016454 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 648999016455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999016456 active site 648999016457 motif I; other site 648999016458 motif II; other site 648999016459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999016460 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 648999016461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 648999016462 active site 648999016463 motif I; other site 648999016464 motif II; other site 648999016465 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 648999016466 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 648999016467 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 648999016468 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 648999016469 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 648999016470 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 648999016471 Amidinotransferase; Region: Amidinotransf; pfam02274 648999016472 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 648999016473 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 648999016474 putative DNA binding site [nucleotide binding]; other site 648999016475 putative Zn2+ binding site [ion binding]; other site 648999016476 AsnC family; Region: AsnC_trans_reg; pfam01037 648999016477 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 648999016478 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 648999016479 NAD(P) binding site [chemical binding]; other site 648999016480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 648999016481 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 648999016482 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 648999016483 Fructosamine kinase; Region: Fructosamin_kin; cl17579 648999016484 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 648999016485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 648999016486 FeS/SAM binding site; other site 648999016487 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 648999016488 Ubiquitin-like proteins; Region: UBQ; cl00155 648999016489 charged pocket; other site 648999016490 hydrophobic patch; other site 648999016491 phosphodiesterase YaeI; Provisional; Region: PRK11340 648999016492 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 648999016493 putative active site [active] 648999016494 putative metal binding site [ion binding]; other site 648999016495 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 648999016496 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 648999016497 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 648999016498 Part of AAA domain; Region: AAA_19; pfam13245 648999016499 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 648999016500 Family description; Region: UvrD_C_2; pfam13538 648999016501 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 648999016502 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 648999016503 AAA ATPase domain; Region: AAA_16; pfam13191 648999016504 Predicted acetyltransferase [General function prediction only]; Region: COG3153 648999016505 DoxX; Region: DoxX; pfam07681 648999016506 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 648999016507 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 648999016508 MoaE homodimer interface [polypeptide binding]; other site 648999016509 MoaD interaction [polypeptide binding]; other site 648999016510 active site residues [active] 648999016511 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 648999016512 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 648999016513 dimer interface [polypeptide binding]; other site 648999016514 putative functional site; other site 648999016515 putative MPT binding site; other site 648999016516 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 648999016517 MPT binding site; other site 648999016518 trimer interface [polypeptide binding]; other site 648999016519 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 648999016520 trimer interface [polypeptide binding]; other site 648999016521 dimer interface [polypeptide binding]; other site 648999016522 putative active site [active] 648999016523 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 648999016524 DNA binding site [nucleotide binding] 648999016525 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 648999016526 NB-ARC domain; Region: NB-ARC; pfam00931 648999016527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 648999016529 binding surface 648999016530 TPR motif; other site 648999016531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 648999016532 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 648999016533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 648999016534 metal binding site [ion binding]; metal-binding site 648999016535 active site 648999016536 I-site; other site 648999016537 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 648999016538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 648999016539 active site 648999016540 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 648999016541 TIGR03086 family protein; Region: TIGR03086 648999016542 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 648999016543 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 648999016544 Walker A motif; other site 648999016545 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 648999016546 Homing endonuclease; Region: Hom_end; pfam05204 648999016547 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 648999016548 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 648999016549 Walker A motif; other site 648999016550 ATP binding site [chemical binding]; other site 648999016551 Walker B motif; other site 648999016552 DNA binding loops [nucleotide binding] 648999016553 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 648999016554 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 648999016555 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 648999016556 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 648999016557 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 648999016558 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 648999016559 dimer interface [polypeptide binding]; other site 648999016560 ssDNA binding site [nucleotide binding]; other site 648999016561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 648999016562 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 648999016563 endonuclease IV; Provisional; Region: PRK01060 648999016564 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 648999016565 AP (apurinic/apyrimidinic) site pocket; other site 648999016566 DNA interaction; other site 648999016567 Metal-binding active site; metal-binding site 648999016568 Predicted integral membrane protein [Function unknown]; Region: COG5650 648999016569 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 648999016570 Transglycosylase; Region: Transgly; pfam00912 648999016571 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 648999016572 Predicted transcriptional regulators [Transcription]; Region: COG1695 648999016573 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 648999016574 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 648999016575 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 648999016576 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 648999016577 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 648999016578 DNA binding site [nucleotide binding] 648999016579 active site 648999016580 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 648999016581 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 648999016582 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 648999016583 calcium binding site 2 [ion binding]; other site 648999016584 active site 648999016585 catalytic triad [active] 648999016586 calcium binding site 1 [ion binding]; other site 648999016587 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 648999016588 PKC phosphorylation site [posttranslational modification]; other site 648999016589 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 648999016590 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 648999016591 active site 648999016592 NTP binding site [chemical binding]; other site 648999016593 metal binding triad [ion binding]; metal-binding site 648999016594 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 648999016595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 648999016596 Zn2+ binding site [ion binding]; other site 648999016597 Mg2+ binding site [ion binding]; other site 648999016598 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 648999016599 MviN-like protein; Region: MVIN; pfam03023 648999016600 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 648999016601 active site 648999016602 ATP binding site [chemical binding]; other site 648999016603 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 648999016604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 648999016605 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 648999016606 DNA binding residues [nucleotide binding] 648999016607 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 648999016608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 648999016609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 648999016610 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 648999016611 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 648999016612 catalytic residues [active] 648999016613 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 648999016614 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999016615 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 648999016616 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 648999016617 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 648999016618 active site 648999016619 metal binding site [ion binding]; metal-binding site 648999016620 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 648999016621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 648999016622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 648999016623 homodimer interface [polypeptide binding]; other site 648999016624 catalytic residue [active] 648999016625 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 648999016626 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 648999016627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 648999016628 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 648999016629 ParB-like nuclease domain; Region: ParBc; pfam02195 648999016630 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 648999016631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 648999016632 Magnesium ion binding site [ion binding]; other site 648999016633 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 648999016634 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 648999016635 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 648999016636 G-X-X-G motif; other site 648999016637 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 648999016638 RxxxH motif; other site 648999016639 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 648999016640 Haemolytic domain; Region: Haemolytic; pfam01809 648999016641 Ribonuclease P; Region: Ribonuclease_P; pfam00825 648999016642 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399