-- dump date 20140619_150244 -- class Genbank::misc_feature -- table misc_feature_note -- id note 477641000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 477641000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 477641000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641000004 Walker A motif; other site 477641000005 ATP binding site [chemical binding]; other site 477641000006 Walker B motif; other site 477641000007 arginine finger; other site 477641000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 477641000009 DnaA box-binding interface [nucleotide binding]; other site 477641000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 477641000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 477641000012 putative DNA binding surface [nucleotide binding]; other site 477641000013 dimer interface [polypeptide binding]; other site 477641000014 beta-clamp/clamp loader binding surface; other site 477641000015 beta-clamp/translesion DNA polymerase binding surface; other site 477641000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 477641000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 477641000018 recombination protein F; Reviewed; Region: recF; PRK00064 477641000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 477641000020 Walker A/P-loop; other site 477641000021 ATP binding site [chemical binding]; other site 477641000022 Q-loop/lid; other site 477641000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641000024 ABC transporter signature motif; other site 477641000025 Walker B; other site 477641000026 D-loop; other site 477641000027 H-loop/switch region; other site 477641000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 477641000029 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641000030 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641000032 Walker A/P-loop; other site 477641000033 ATP binding site [chemical binding]; other site 477641000034 Q-loop/lid; other site 477641000035 ABC transporter signature motif; other site 477641000036 Walker B; other site 477641000037 D-loop; other site 477641000038 H-loop/switch region; other site 477641000039 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641000040 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 477641000041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641000042 ATP binding site [chemical binding]; other site 477641000043 Mg2+ binding site [ion binding]; other site 477641000044 G-X-G motif; other site 477641000045 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 477641000046 anchoring element; other site 477641000047 dimer interface [polypeptide binding]; other site 477641000048 ATP binding site [chemical binding]; other site 477641000049 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 477641000050 active site 477641000051 putative metal-binding site [ion binding]; other site 477641000052 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 477641000053 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 477641000054 CAP-like domain; other site 477641000055 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 477641000056 active site 477641000057 protein-splicing catalytic site; other site 477641000058 thioester formation/cholesterol transfer; other site 477641000059 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 477641000060 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 477641000061 DNA gyrase subunit A; Validated; Region: PRK05560 477641000062 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 477641000063 primary dimer interface [polypeptide binding]; other site 477641000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 477641000070 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 477641000071 PAS fold; Region: PAS_4; pfam08448 477641000072 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000073 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641000074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 477641000075 ATP binding site [chemical binding]; other site 477641000076 Mg2+ binding site [ion binding]; other site 477641000077 G-X-G motif; other site 477641000078 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641000079 anti sigma factor interaction site; other site 477641000080 regulatory phosphorylation site [posttranslational modification]; other site 477641000081 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 477641000082 active site 477641000083 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 477641000084 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 477641000085 putative septation inhibitor protein; Reviewed; Region: PRK00159 477641000086 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 477641000087 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 477641000088 Glutamine amidotransferase class-I; Region: GATase; pfam00117 477641000089 glutamine binding [chemical binding]; other site 477641000090 catalytic triad [active] 477641000091 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 477641000092 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641000093 active site 477641000094 ATP binding site [chemical binding]; other site 477641000095 substrate binding site [chemical binding]; other site 477641000096 activation loop (A-loop); other site 477641000097 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641000098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641000099 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641000100 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641000101 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641000102 active site 477641000103 ATP binding site [chemical binding]; other site 477641000104 substrate binding site [chemical binding]; other site 477641000105 activation loop (A-loop); other site 477641000106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 477641000107 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 477641000108 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 477641000109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 477641000110 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 477641000111 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 477641000112 active site 477641000113 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 477641000114 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 477641000115 phosphopeptide binding site; other site 477641000116 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 477641000117 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 477641000118 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 477641000119 phosphopeptide binding site; other site 477641000120 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 477641000121 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 477641000122 active site 477641000123 catalytic residues [active] 477641000124 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 477641000125 MOSC domain; Region: MOSC; pfam03473 477641000126 S4 domain; Region: S4_2; pfam13275 477641000127 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 477641000128 putative catalytic site [active] 477641000129 putative metal binding site [ion binding]; other site 477641000130 putative phosphate binding site [ion binding]; other site 477641000131 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641000132 putative catalytic site [active] 477641000133 putative phosphate binding site [ion binding]; other site 477641000134 putative metal binding site [ion binding]; other site 477641000135 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 477641000136 putative active site; other site 477641000137 putative metal binding residues [ion binding]; other site 477641000138 signature motif; other site 477641000139 putative triphosphate binding site [ion binding]; other site 477641000140 CHAD domain; Region: CHAD; pfam05235 477641000141 6-phosphofructokinase; Provisional; Region: PRK03202 477641000142 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 477641000143 active site 477641000144 ADP/pyrophosphate binding site [chemical binding]; other site 477641000145 dimerization interface [polypeptide binding]; other site 477641000146 allosteric effector site; other site 477641000147 fructose-1,6-bisphosphate binding site; other site 477641000148 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 477641000149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641000150 DNA-binding site [nucleotide binding]; DNA binding site 477641000151 UTRA domain; Region: UTRA; pfam07702 477641000152 GAF domain; Region: GAF; pfam01590 477641000153 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641000154 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 477641000155 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641000157 S-adenosylmethionine binding site [chemical binding]; other site 477641000158 enoyl-CoA hydratase; Provisional; Region: PRK08140 477641000159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641000160 substrate binding site [chemical binding]; other site 477641000161 oxyanion hole (OAH) forming residues; other site 477641000162 trimer interface [polypeptide binding]; other site 477641000163 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 477641000164 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 477641000165 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 477641000166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641000167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641000168 DNA binding residues [nucleotide binding] 477641000169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641000170 nucleotide binding site [chemical binding]; other site 477641000171 Dynamin family; Region: Dynamin_N; pfam00350 477641000172 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641000173 G3 box; other site 477641000174 Switch II region; other site 477641000175 GTP/Mg2+ binding site [chemical binding]; other site 477641000176 G4 box; other site 477641000177 G5 box; other site 477641000178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641000179 G1 box; other site 477641000180 GTP/Mg2+ binding site [chemical binding]; other site 477641000181 G2 box; other site 477641000182 Switch I region; other site 477641000183 G3 box; other site 477641000184 Switch II region; other site 477641000185 G4 box; other site 477641000186 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 477641000187 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641000188 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 477641000189 CoenzymeA binding site [chemical binding]; other site 477641000190 subunit interaction site [polypeptide binding]; other site 477641000191 PHB binding site; other site 477641000192 Putative cyclase; Region: Cyclase; pfam04199 477641000193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641000194 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 477641000195 acyl-activating enzyme (AAE) consensus motif; other site 477641000196 AMP binding site [chemical binding]; other site 477641000197 active site 477641000198 CoA binding site [chemical binding]; other site 477641000199 Iron permease FTR1 family; Region: FTR1; cl00475 477641000200 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 477641000201 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 477641000202 Imelysin; Region: Peptidase_M75; pfam09375 477641000203 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 477641000204 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 477641000205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641000206 YCII-related domain; Region: YCII; cl00999 477641000207 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641000208 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641000209 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 477641000210 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641000211 dimer interface [polypeptide binding]; other site 477641000212 active site 477641000213 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 477641000214 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641000215 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641000216 active site 477641000217 ATP binding site [chemical binding]; other site 477641000218 substrate binding site [chemical binding]; other site 477641000219 activation loop (A-loop); other site 477641000220 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 477641000221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000222 PAS domain; Region: PAS_9; pfam13426 477641000223 putative active site [active] 477641000224 heme pocket [chemical binding]; other site 477641000225 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000226 competence damage-inducible protein A; Provisional; Region: PRK00549 477641000227 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 477641000228 MPT binding site; other site 477641000229 Competence-damaged protein; Region: CinA; pfam02464 477641000230 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 477641000231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641000232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641000233 active site 477641000234 LabA_like proteins; Region: LabA_like; cd06167 477641000235 putative metal binding site [ion binding]; other site 477641000236 PRC-barrel domain; Region: PRC; pfam05239 477641000237 AAA domain; Region: AAA_33; pfam13671 477641000238 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641000239 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641000240 anti sigma factor interaction site; other site 477641000241 regulatory phosphorylation site [posttranslational modification]; other site 477641000242 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 477641000243 active site 477641000244 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 477641000245 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 477641000246 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641000247 GAF domain; Region: GAF; pfam01590 477641000248 PAS fold; Region: PAS_3; pfam08447 477641000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000250 putative active site [active] 477641000251 heme pocket [chemical binding]; other site 477641000252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000253 PAS domain; Region: PAS_9; pfam13426 477641000254 putative active site [active] 477641000255 heme pocket [chemical binding]; other site 477641000256 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000257 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641000258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 477641000259 ATP binding site [chemical binding]; other site 477641000260 Mg2+ binding site [ion binding]; other site 477641000261 G-X-G motif; other site 477641000262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641000263 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 477641000264 Walker A/P-loop; other site 477641000265 ATP binding site [chemical binding]; other site 477641000266 Q-loop/lid; other site 477641000267 ABC transporter signature motif; other site 477641000268 Walker B; other site 477641000269 D-loop; other site 477641000270 H-loop/switch region; other site 477641000271 Cobalt transport protein; Region: CbiQ; cl00463 477641000272 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 477641000273 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 477641000274 Walker A/P-loop; other site 477641000275 ATP binding site [chemical binding]; other site 477641000276 Q-loop/lid; other site 477641000277 ABC transporter signature motif; other site 477641000278 Walker B; other site 477641000279 D-loop; other site 477641000280 H-loop/switch region; other site 477641000281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 477641000282 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 477641000283 Walker A/P-loop; other site 477641000284 ATP binding site [chemical binding]; other site 477641000285 Q-loop/lid; other site 477641000286 ABC transporter signature motif; other site 477641000287 Walker B; other site 477641000288 D-loop; other site 477641000289 H-loop/switch region; other site 477641000290 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 477641000291 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 477641000292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641000293 NAD(P) binding site [chemical binding]; other site 477641000294 active site 477641000295 short chain dehydrogenase; Provisional; Region: PRK07024 477641000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641000297 NAD(P) binding site [chemical binding]; other site 477641000298 active site 477641000299 RibD C-terminal domain; Region: RibD_C; cl17279 477641000300 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 477641000301 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 477641000302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 477641000303 Clp protease; Region: CLP_protease; pfam00574 477641000304 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 477641000305 oligomer interface [polypeptide binding]; other site 477641000306 active site residues [active] 477641000307 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641000308 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 477641000309 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641000310 CoenzymeA binding site [chemical binding]; other site 477641000311 subunit interaction site [polypeptide binding]; other site 477641000312 PHB binding site; other site 477641000313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641000314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641000315 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 477641000316 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641000317 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641000318 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 477641000319 active site residue [active] 477641000320 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641000321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641000322 DNA-binding site [nucleotide binding]; DNA binding site 477641000323 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 477641000324 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 477641000325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641000326 catalytic residue [active] 477641000327 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 477641000328 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 477641000329 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 477641000330 Prostaglandin dehydrogenases; Region: PGDH; cd05288 477641000331 NAD(P) binding site [chemical binding]; other site 477641000332 substrate binding site [chemical binding]; other site 477641000333 dimer interface [polypeptide binding]; other site 477641000334 sorbitol dehydrogenase; Provisional; Region: PRK07067 477641000335 classical (c) SDRs; Region: SDR_c; cd05233 477641000336 NAD(P) binding site [chemical binding]; other site 477641000337 active site 477641000338 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 477641000339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641000340 S-adenosylmethionine binding site [chemical binding]; other site 477641000341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641000342 active site 477641000343 urate oxidase; Region: urate_oxi; TIGR03383 477641000344 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 477641000345 active site 477641000346 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 477641000347 active site 477641000348 homotetramer interface [polypeptide binding]; other site 477641000349 putative OHCU decarboxylase; Provisional; Region: PRK13798 477641000350 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641000351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641000352 ATP binding site [chemical binding]; other site 477641000353 Mg2+ binding site [ion binding]; other site 477641000354 G-X-G motif; other site 477641000355 maltose O-acetyltransferase; Provisional; Region: PRK10092 477641000356 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 477641000357 active site 477641000358 substrate binding site [chemical binding]; other site 477641000359 trimer interface [polypeptide binding]; other site 477641000360 CoA binding site [chemical binding]; other site 477641000361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641000362 NAD(P) binding site [chemical binding]; other site 477641000363 NADH(P)-binding; Region: NAD_binding_10; pfam13460 477641000364 active site 477641000365 MarR family; Region: MarR_2; cl17246 477641000366 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641000367 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641000368 anti sigma factor interaction site; other site 477641000369 regulatory phosphorylation site [posttranslational modification]; other site 477641000370 Predicted flavoprotein [General function prediction only]; Region: COG0431 477641000371 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 477641000372 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 477641000373 dimer interface [polypeptide binding]; other site 477641000374 ADP-ribose binding site [chemical binding]; other site 477641000375 active site 477641000376 nudix motif; other site 477641000377 metal binding site [ion binding]; metal-binding site 477641000378 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 477641000379 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 477641000380 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 477641000381 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 477641000382 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 477641000383 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 477641000384 hypothetical protein; Provisional; Region: PRK07758 477641000385 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641000386 active site 477641000387 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641000388 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641000389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 477641000390 catalytic residues [active] 477641000391 Dienelactone hydrolase family; Region: DLH; pfam01738 477641000392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641000393 MarR family; Region: MarR; pfam01047 477641000394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641000395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641000396 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 477641000397 Walker A/P-loop; other site 477641000398 ATP binding site [chemical binding]; other site 477641000399 Q-loop/lid; other site 477641000400 ABC transporter signature motif; other site 477641000401 Walker B; other site 477641000402 D-loop; other site 477641000403 H-loop/switch region; other site 477641000404 short chain dehydrogenase; Provisional; Region: PRK08263 477641000405 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 477641000406 NADP binding site [chemical binding]; other site 477641000407 active site 477641000408 steroid binding site; other site 477641000409 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 477641000410 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 477641000411 FMN binding site [chemical binding]; other site 477641000412 active site 477641000413 substrate binding site [chemical binding]; other site 477641000414 catalytic residue [active] 477641000415 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 477641000416 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 477641000417 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 477641000418 hypothetical protein; Provisional; Region: PRK06184 477641000419 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641000420 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 477641000421 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 477641000422 active site 477641000423 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 477641000424 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 477641000425 dimer interface [polypeptide binding]; other site 477641000426 active site 477641000427 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 477641000428 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 477641000429 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 477641000430 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 477641000431 putative hydrophobic ligand binding site [chemical binding]; other site 477641000432 active site 477641000433 catalytic residues_2 [active] 477641000434 catalytic residues_1 [active] 477641000435 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 477641000436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641000437 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641000438 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 477641000439 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 477641000440 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641000441 carboxyltransferase (CT) interaction site; other site 477641000442 biotinylation site [posttranslational modification]; other site 477641000443 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 477641000444 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 477641000445 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 477641000446 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 477641000447 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641000448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 477641000449 active site 477641000450 dimerization interface [polypeptide binding]; other site 477641000451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641000452 DNA binding residues [nucleotide binding] 477641000453 dimerization interface [polypeptide binding]; other site 477641000454 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641000455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641000456 DNA binding residues [nucleotide binding] 477641000457 dimerization interface [polypeptide binding]; other site 477641000458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641000459 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 477641000460 Walker A/P-loop; other site 477641000461 ATP binding site [chemical binding]; other site 477641000462 Q-loop/lid; other site 477641000463 ABC transporter signature motif; other site 477641000464 Walker B; other site 477641000465 D-loop; other site 477641000466 H-loop/switch region; other site 477641000467 putative pectinesterase; Region: PLN02432; cl01911 477641000468 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 477641000469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641000471 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 477641000472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641000473 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 477641000474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641000475 DNA-binding site [nucleotide binding]; DNA binding site 477641000476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641000477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641000478 homodimer interface [polypeptide binding]; other site 477641000479 catalytic residue [active] 477641000480 Uncharacterized conserved protein [Function unknown]; Region: COG1479 477641000481 Protein of unknown function DUF262; Region: DUF262; pfam03235 477641000482 Uncharacterized conserved protein [Function unknown]; Region: COG3472 477641000483 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 477641000484 putative hydrophobic ligand binding site [chemical binding]; other site 477641000485 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 477641000486 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641000487 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641000488 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641000489 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641000490 catalytic loop [active] 477641000491 iron binding site [ion binding]; other site 477641000492 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641000493 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 477641000494 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 477641000495 membrane protein FdrA; Validated; Region: PRK06091 477641000496 CoA-ligase; Region: Ligase_CoA; pfam00549 477641000497 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 477641000498 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 477641000499 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 477641000500 PAS fold; Region: PAS_4; pfam08448 477641000501 GAF domain; Region: GAF; cl17456 477641000502 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000503 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641000505 classical (c) SDRs; Region: SDR_c; cd05233 477641000506 NAD(P) binding site [chemical binding]; other site 477641000507 active site 477641000508 Transcriptional regulator [Transcription]; Region: LytR; COG1316 477641000509 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 477641000510 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 477641000511 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 477641000512 putative substrate binding site [chemical binding]; other site 477641000513 nucleotide binding site [chemical binding]; other site 477641000514 nucleotide binding site [chemical binding]; other site 477641000515 homodimer interface [polypeptide binding]; other site 477641000516 histidinol-phosphatase; Provisional; Region: PRK05588 477641000517 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 477641000518 active site 477641000519 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 477641000520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641000521 ATP binding site [chemical binding]; other site 477641000522 putative Mg++ binding site [ion binding]; other site 477641000523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641000524 nucleotide binding region [chemical binding]; other site 477641000525 ATP-binding site [chemical binding]; other site 477641000526 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 477641000527 potential protein location (protein of unknown function [Modestobacter marinus]) that overlaps RNA (ribosomal RNA 16S ribosomal RNA) 477641000528 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 477641000529 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641000530 Walker A/P-loop; other site 477641000531 ATP binding site [chemical binding]; other site 477641000532 Q-loop/lid; other site 477641000533 ABC transporter signature motif; other site 477641000534 Walker B; other site 477641000535 D-loop; other site 477641000536 H-loop/switch region; other site 477641000537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641000538 DNA-binding site [nucleotide binding]; DNA binding site 477641000539 Predicted transcriptional regulators [Transcription]; Region: COG1695 477641000540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641000541 putative DNA binding site [nucleotide binding]; other site 477641000542 putative Zn2+ binding site [ion binding]; other site 477641000543 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 477641000544 alpha-gamma subunit interface [polypeptide binding]; other site 477641000545 beta-gamma subunit interface [polypeptide binding]; other site 477641000546 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 477641000547 gamma-beta subunit interface [polypeptide binding]; other site 477641000548 alpha-beta subunit interface [polypeptide binding]; other site 477641000549 urease subunit alpha; Reviewed; Region: ureC; PRK13206 477641000550 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 477641000551 subunit interactions [polypeptide binding]; other site 477641000552 active site 477641000553 flap region; other site 477641000554 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 477641000555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641000556 UreD urease accessory protein; Region: UreD; cl00530 477641000557 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 477641000558 allantoinase; Region: allantoinase; TIGR03178 477641000559 active site 477641000560 allantoicase; Provisional; Region: PRK13257 477641000561 Allantoicase repeat; Region: Allantoicase; pfam03561 477641000562 Allantoicase repeat; Region: Allantoicase; pfam03561 477641000563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641000564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641000565 metal binding site [ion binding]; metal-binding site 477641000566 active site 477641000567 I-site; other site 477641000568 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 477641000569 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641000570 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641000571 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641000572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 477641000573 catalytic loop [active] 477641000574 iron binding site [ion binding]; other site 477641000575 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641000576 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 477641000577 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 477641000578 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 477641000579 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 477641000580 active site 477641000581 putative substrate binding pocket [chemical binding]; other site 477641000582 Anti-sigma-K factor rskA; Region: RskA; pfam10099 477641000583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641000584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641000585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641000586 DNA binding residues [nucleotide binding] 477641000587 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 477641000588 active site 477641000589 putative catalytic site [active] 477641000590 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 477641000591 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 477641000592 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641000593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641000594 catalytic residue [active] 477641000595 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641000596 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641000597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641000598 ATP binding site [chemical binding]; other site 477641000599 Mg2+ binding site [ion binding]; other site 477641000600 G-X-G motif; other site 477641000601 Domain of unknown function (DUF309); Region: DUF309; pfam03745 477641000602 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641000603 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 477641000604 Malic enzyme, N-terminal domain; Region: malic; pfam00390 477641000605 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 477641000606 NAD(P) binding pocket [chemical binding]; other site 477641000607 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 477641000608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641000609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641000610 homodimer interface [polypeptide binding]; other site 477641000611 catalytic residue [active] 477641000612 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 477641000613 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 477641000614 putative DNA binding site [nucleotide binding]; other site 477641000615 catalytic residue [active] 477641000616 putative H2TH interface [polypeptide binding]; other site 477641000617 putative catalytic residues [active] 477641000618 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 477641000619 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 477641000620 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 477641000621 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641000622 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 477641000623 FtsX-like permease family; Region: FtsX; pfam02687 477641000624 FtsX-like permease family; Region: FtsX; pfam02687 477641000625 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 477641000626 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641000627 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 477641000628 Walker A/P-loop; other site 477641000629 ATP binding site [chemical binding]; other site 477641000630 Q-loop/lid; other site 477641000631 ABC transporter signature motif; other site 477641000632 Walker B; other site 477641000633 D-loop; other site 477641000634 H-loop/switch region; other site 477641000635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641000636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641000637 active site 477641000638 phosphorylation site [posttranslational modification] 477641000639 intermolecular recognition site; other site 477641000640 dimerization interface [polypeptide binding]; other site 477641000641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641000642 DNA binding residues [nucleotide binding] 477641000643 dimerization interface [polypeptide binding]; other site 477641000644 Histidine kinase; Region: HisKA_3; pfam07730 477641000645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641000646 ATP binding site [chemical binding]; other site 477641000647 Mg2+ binding site [ion binding]; other site 477641000648 G-X-G motif; other site 477641000649 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 477641000650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641000651 active site 477641000652 motif I; other site 477641000653 motif II; other site 477641000654 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641000655 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 477641000656 Ligand Binding Site [chemical binding]; other site 477641000657 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 477641000658 iron-sulfur cluster [ion binding]; other site 477641000659 [2Fe-2S] cluster binding site [ion binding]; other site 477641000660 Protein of unknown function, DUF485; Region: DUF485; pfam04341 477641000661 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 477641000662 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 477641000663 Na binding site [ion binding]; other site 477641000664 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 477641000665 dimanganese center [ion binding]; other site 477641000666 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 477641000667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641000668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641000669 ATP binding site [chemical binding]; other site 477641000670 Mg2+ binding site [ion binding]; other site 477641000671 G-X-G motif; other site 477641000672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641000673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641000674 DNA binding residues [nucleotide binding] 477641000675 Uncharacterized conserved protein [Function unknown]; Region: COG3268 477641000676 MutL protein; Region: MutL; pfam13941 477641000677 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 477641000678 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 477641000679 Bacterial PH domain; Region: DUF304; pfam03703 477641000680 Bacterial PH domain; Region: DUF304; cl01348 477641000681 Bacterial PH domain; Region: DUF304; pfam03703 477641000682 Bacterial PH domain; Region: DUF304; pfam03703 477641000683 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641000684 active site residue [active] 477641000685 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 477641000686 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 477641000687 dimer interface [polypeptide binding]; other site 477641000688 acyl-activating enzyme (AAE) consensus motif; other site 477641000689 putative active site [active] 477641000690 AMP binding site [chemical binding]; other site 477641000691 putative CoA binding site [chemical binding]; other site 477641000692 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 477641000693 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 477641000694 putative ligand binding site [chemical binding]; other site 477641000695 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641000696 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641000697 Walker A/P-loop; other site 477641000698 ATP binding site [chemical binding]; other site 477641000699 Q-loop/lid; other site 477641000700 ABC transporter signature motif; other site 477641000701 Walker B; other site 477641000702 D-loop; other site 477641000703 H-loop/switch region; other site 477641000704 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641000705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641000706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641000707 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641000708 TM-ABC transporter signature motif; other site 477641000709 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641000710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641000711 DNA binding site [nucleotide binding] 477641000712 domain linker motif; other site 477641000713 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 477641000714 ligand binding site [chemical binding]; other site 477641000715 dimerization interface (open form) [polypeptide binding]; other site 477641000716 dimerization interface (closed form) [polypeptide binding]; other site 477641000717 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641000718 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 477641000719 nucleotide binding site [chemical binding]; other site 477641000720 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 477641000721 intersubunit interface [polypeptide binding]; other site 477641000722 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 477641000723 active site 477641000724 Zn2+ binding site [ion binding]; other site 477641000725 L-arabinose isomerase; Provisional; Region: PRK02929 477641000726 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 477641000727 hexamer (dimer of trimers) interface [polypeptide binding]; other site 477641000728 trimer interface [polypeptide binding]; other site 477641000729 substrate binding site [chemical binding]; other site 477641000730 Mn binding site [ion binding]; other site 477641000731 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641000732 Cytochrome P450; Region: p450; cl12078 477641000733 SEC-C motif; Region: SEC-C; pfam02810 477641000734 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 477641000735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641000736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641000737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641000738 DNA binding residues [nucleotide binding] 477641000739 Predicted integral membrane protein [Function unknown]; Region: COG5660 477641000740 arginine deiminase; Provisional; Region: PRK01388 477641000741 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 477641000742 DNA binding site [nucleotide binding] 477641000743 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 477641000744 AAA ATPase domain; Region: AAA_16; pfam13191 477641000745 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641000746 FAD binding domain; Region: FAD_binding_4; pfam01565 477641000747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641000748 anti sigma factor interaction site; other site 477641000749 regulatory phosphorylation site [posttranslational modification]; other site 477641000750 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641000751 FAD binding domain; Region: FAD_binding_4; pfam01565 477641000752 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 477641000753 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 477641000754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641000755 S-adenosylmethionine binding site [chemical binding]; other site 477641000756 Protein of unknown function (DUF419); Region: DUF419; cl15265 477641000757 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641000758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641000759 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 477641000760 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 477641000761 DNA binding residues [nucleotide binding] 477641000762 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 477641000763 haloalkane dehalogenase; Provisional; Region: PRK03592 477641000764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641000765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641000766 metal binding site [ion binding]; metal-binding site 477641000767 active site 477641000768 I-site; other site 477641000769 GAF domain; Region: GAF; pfam01590 477641000770 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641000771 PAS domain; Region: PAS_10; pfam13596 477641000772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000773 putative active site [active] 477641000774 heme pocket [chemical binding]; other site 477641000775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641000776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641000777 metal binding site [ion binding]; metal-binding site 477641000778 active site 477641000779 I-site; other site 477641000780 Predicted membrane protein [Function unknown]; Region: COG2119 477641000781 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 477641000782 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 477641000783 hypothetical protein; Provisional; Region: PRK04194 477641000784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641000785 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641000786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641000787 metal binding site [ion binding]; metal-binding site 477641000788 active site 477641000789 I-site; other site 477641000790 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 477641000791 AIR carboxylase; Region: AIRC; cl00310 477641000792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641000793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641000794 metal binding site [ion binding]; metal-binding site 477641000795 active site 477641000796 I-site; other site 477641000797 prephenate dehydratase; Provisional; Region: PRK11898 477641000798 Prephenate dehydratase; Region: PDT; pfam00800 477641000799 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 477641000800 putative L-Phe binding site [chemical binding]; other site 477641000801 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 477641000802 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641000803 putative NAD(P) binding site [chemical binding]; other site 477641000804 cinnamyl-alcohol dehydrogenase; Region: PLN02514 477641000805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 477641000806 putative NAD(P) binding site [chemical binding]; other site 477641000807 catalytic Zn binding site [ion binding]; other site 477641000808 putative substrate binding site [chemical binding]; other site 477641000809 structural Zn binding site [ion binding]; other site 477641000810 dimer interface [polypeptide binding]; other site 477641000811 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 477641000812 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641000813 DNA binding residues [nucleotide binding] 477641000814 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 477641000815 oligomerisation interface [polypeptide binding]; other site 477641000816 mobile loop; other site 477641000817 roof hairpin; other site 477641000818 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 477641000819 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 477641000820 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 477641000821 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 477641000822 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 477641000823 active site 477641000824 seryl-tRNA synthetase; Provisional; Region: PRK05431 477641000825 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 477641000826 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 477641000827 dimer interface [polypeptide binding]; other site 477641000828 active site 477641000829 motif 1; other site 477641000830 motif 2; other site 477641000831 motif 3; other site 477641000832 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 477641000833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 477641000834 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641000835 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641000836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641000837 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 477641000838 active site 477641000839 motif I; other site 477641000840 motif II; other site 477641000841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 477641000842 dimerization interface [polypeptide binding]; other site 477641000843 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641000844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641000845 dimer interface [polypeptide binding]; other site 477641000846 putative CheW interface [polypeptide binding]; other site 477641000847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000848 PAS domain; Region: PAS_9; pfam13426 477641000849 putative active site [active] 477641000850 heme pocket [chemical binding]; other site 477641000851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000852 PAS domain; Region: PAS_9; pfam13426 477641000853 putative active site [active] 477641000854 heme pocket [chemical binding]; other site 477641000855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000856 PAS domain; Region: PAS_9; pfam13426 477641000857 putative active site [active] 477641000858 heme pocket [chemical binding]; other site 477641000859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000860 PAS domain; Region: PAS_9; pfam13426 477641000861 putative active site [active] 477641000862 heme pocket [chemical binding]; other site 477641000863 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641000864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641000865 dimer interface [polypeptide binding]; other site 477641000866 putative CheW interface [polypeptide binding]; other site 477641000867 CheW-like domain; Region: CheW; pfam01584 477641000868 CheW-like domain; Region: CheW; pfam01584 477641000869 CheW-like domain; Region: CheW; pfam01584 477641000870 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 477641000871 Domain of unknown function (DUF336); Region: DUF336; cl01249 477641000872 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 477641000873 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 477641000874 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 477641000875 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 477641000876 alpha-beta subunit interface [polypeptide binding]; other site 477641000877 alpha-gamma subunit interface [polypeptide binding]; other site 477641000878 active site 477641000879 substrate and K+ binding site; other site 477641000880 K+ binding site [ion binding]; other site 477641000881 cobalamin binding site [chemical binding]; other site 477641000882 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 477641000883 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 477641000884 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 477641000885 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 477641000886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 477641000887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641000888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641000889 catalytic residue [active] 477641000890 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 477641000891 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 477641000892 NAD(P) binding site [chemical binding]; other site 477641000893 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641000894 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641000895 4-coumarate--CoA ligase; Region: PLN02246 477641000896 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 477641000897 acyl-activating enzyme (AAE) consensus motif; other site 477641000898 active site 477641000899 putative CoA binding site [chemical binding]; other site 477641000900 AMP binding site [chemical binding]; other site 477641000901 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641000902 CoenzymeA binding site [chemical binding]; other site 477641000903 subunit interaction site [polypeptide binding]; other site 477641000904 PHB binding site; other site 477641000905 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 477641000906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641000907 Protein of unknown function (DUF664); Region: DUF664; pfam04978 477641000908 dihydropteroate synthase; Region: DHPS; TIGR01496 477641000909 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 477641000910 substrate binding pocket [chemical binding]; other site 477641000911 dimer interface [polypeptide binding]; other site 477641000912 inhibitor binding site; inhibition site 477641000913 Protein of unknown function (DUF664); Region: DUF664; pfam04978 477641000914 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641000915 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641000916 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641000917 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 477641000918 IHF dimer interface [polypeptide binding]; other site 477641000919 IHF - DNA interface [nucleotide binding]; other site 477641000920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641000921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641000922 active site 477641000923 catalytic tetrad [active] 477641000924 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 477641000925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641000926 GAF domain; Region: GAF; pfam01590 477641000927 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641000928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641000929 PAS fold; Region: PAS_3; pfam08447 477641000930 putative active site [active] 477641000931 heme pocket [chemical binding]; other site 477641000932 GAF domain; Region: GAF_3; pfam13492 477641000933 GAF domain; Region: GAF_2; pfam13185 477641000934 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641000935 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641000936 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641000937 Predicted membrane protein [Function unknown]; Region: COG2860 477641000938 UPF0126 domain; Region: UPF0126; pfam03458 477641000939 UPF0126 domain; Region: UPF0126; pfam03458 477641000940 Amidase; Region: Amidase; cl11426 477641000941 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641000942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641000943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641000944 active site 477641000945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641000946 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 477641000947 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641000948 dimer interface [polypeptide binding]; other site 477641000949 active site 477641000950 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 477641000951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641000952 NAD(P) binding site [chemical binding]; other site 477641000953 active site 477641000954 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 477641000955 active site 2 [active] 477641000956 active site 1 [active] 477641000957 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 477641000958 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 477641000959 active site 477641000960 catalytic site [active] 477641000961 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641000962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 477641000963 ATP binding site [chemical binding]; other site 477641000964 putative Mg++ binding site [ion binding]; other site 477641000965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641000966 nucleotide binding region [chemical binding]; other site 477641000967 ATP-binding site [chemical binding]; other site 477641000968 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 477641000969 active site 477641000970 catalytic residues [active] 477641000971 DNA binding site [nucleotide binding] 477641000972 Int/Topo IB signature motif; other site 477641000973 Helix-turn-helix domain; Region: HTH_17; cl17695 477641000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 477641000975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641000976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641000977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 477641000978 AAA domain; Region: AAA_22; pfam13401 477641000979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641000980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641000981 active site 477641000982 ATP binding site [chemical binding]; other site 477641000983 substrate binding site [chemical binding]; other site 477641000984 activation loop (A-loop); other site 477641000985 HNH endonuclease; Region: HNH_2; pfam13391 477641000986 AAA domain; Region: AAA_23; pfam13476 477641000987 AAA domain; Region: AAA_21; pfam13304 477641000988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641000989 Walker B; other site 477641000990 D-loop; other site 477641000991 H-loop/switch region; other site 477641000992 short chain dehydrogenase; Validated; Region: PRK08264 477641000993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641000994 NAD(P) binding site [chemical binding]; other site 477641000995 active site 477641000996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641000997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641000998 GAF domain; Region: GAF; cl17456 477641000999 ANTAR domain; Region: ANTAR; pfam03861 477641001000 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641001001 RibD C-terminal domain; Region: RibD_C; cl17279 477641001002 Protein of unknown function (DUF419); Region: DUF419; cl15265 477641001003 TIGR03086 family protein; Region: TIGR03086 477641001004 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641001005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641001006 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 477641001007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641001008 putative NAD(P) binding site [chemical binding]; other site 477641001009 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641001010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641001011 NAD(P) binding site [chemical binding]; other site 477641001012 active site 477641001013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641001014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641001015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641001016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641001017 metal binding site [ion binding]; metal-binding site 477641001018 active site 477641001019 I-site; other site 477641001020 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 477641001021 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 477641001022 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 477641001023 putative active site [active] 477641001024 putative catalytic site [active] 477641001025 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 477641001026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641001027 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 477641001028 acyl-activating enzyme (AAE) consensus motif; other site 477641001029 putative AMP binding site [chemical binding]; other site 477641001030 putative active site [active] 477641001031 putative CoA binding site [chemical binding]; other site 477641001032 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 477641001033 active site 477641001034 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641001035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641001036 NAD(P) binding site [chemical binding]; other site 477641001037 active site 477641001038 MarR family; Region: MarR_2; pfam12802 477641001039 PaaX-like protein; Region: PaaX; pfam07848 477641001040 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 477641001041 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641001042 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 477641001043 Walker A/P-loop; other site 477641001044 ATP binding site [chemical binding]; other site 477641001045 Q-loop/lid; other site 477641001046 ABC transporter signature motif; other site 477641001047 Walker B; other site 477641001048 D-loop; other site 477641001049 H-loop/switch region; other site 477641001050 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641001051 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641001052 Walker A/P-loop; other site 477641001053 ATP binding site [chemical binding]; other site 477641001054 Q-loop/lid; other site 477641001055 ABC transporter signature motif; other site 477641001056 Walker B; other site 477641001057 D-loop; other site 477641001058 H-loop/switch region; other site 477641001059 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641001060 TM-ABC transporter signature motif; other site 477641001061 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 477641001062 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641001063 TM-ABC transporter signature motif; other site 477641001064 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641001065 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641001066 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 477641001067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641001068 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641001069 acyl-activating enzyme (AAE) consensus motif; other site 477641001070 acyl-activating enzyme (AAE) consensus motif; other site 477641001071 AMP binding site [chemical binding]; other site 477641001072 active site 477641001073 CoA binding site [chemical binding]; other site 477641001074 TIGR03084 family protein; Region: TIGR03084 477641001075 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 477641001076 NIPSNAP; Region: NIPSNAP; pfam07978 477641001077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641001078 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641001079 active site 477641001080 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 477641001081 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 477641001082 homodimer interface [polypeptide binding]; other site 477641001083 substrate-cofactor binding pocket; other site 477641001084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641001085 catalytic residue [active] 477641001086 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 477641001087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641001088 nudix motif; other site 477641001089 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641001090 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641001091 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641001092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641001093 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 477641001094 substrate binding site [chemical binding]; other site 477641001095 oxyanion hole (OAH) forming residues; other site 477641001096 trimer interface [polypeptide binding]; other site 477641001097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641001098 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 477641001099 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641001100 NAD binding site [chemical binding]; other site 477641001101 catalytic Zn binding site [ion binding]; other site 477641001102 substrate binding site [chemical binding]; other site 477641001103 structural Zn binding site [ion binding]; other site 477641001104 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 477641001105 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 477641001106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641001107 motif II; other site 477641001108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 477641001109 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 477641001110 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 477641001111 LGFP repeat; Region: LGFP; pfam08310 477641001112 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641001113 LGFP repeat; Region: LGFP; pfam08310 477641001114 LGFP repeat; Region: LGFP; pfam08310 477641001115 LGFP repeat; Region: LGFP; pfam08310 477641001116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 477641001117 Membrane protein of unknown function; Region: DUF360; pfam04020 477641001118 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 477641001119 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 477641001120 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641001121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 477641001122 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 477641001123 AMP-binding enzyme; Region: AMP-binding; pfam00501 477641001124 acyl-activating enzyme (AAE) consensus motif; other site 477641001125 AMP binding site [chemical binding]; other site 477641001126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 477641001127 PAS domain; Region: PAS; smart00091 477641001128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641001129 metal binding site [ion binding]; metal-binding site 477641001130 active site 477641001131 I-site; other site 477641001132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641001133 PAS domain S-box; Region: sensory_box; TIGR00229 477641001134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641001135 putative active site [active] 477641001136 heme pocket [chemical binding]; other site 477641001137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641001138 active site 477641001139 I-site; other site 477641001140 metal binding site [ion binding]; metal-binding site 477641001141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641001142 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 477641001143 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 477641001144 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 477641001145 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 477641001146 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 477641001147 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 477641001148 molybdopterin cofactor binding site; other site 477641001149 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 477641001150 4Fe-4S binding domain; Region: Fer4_6; pfam12837 477641001151 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 477641001152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641001153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641001154 I-site; other site 477641001155 active site 477641001156 metal binding site [ion binding]; metal-binding site 477641001157 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 477641001158 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 477641001159 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 477641001160 Probable Catalytic site; other site 477641001161 metal-binding site 477641001162 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 477641001163 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 477641001164 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 477641001165 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 477641001166 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 477641001167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641001168 acyl-activating enzyme (AAE) consensus motif; other site 477641001169 AMP binding site [chemical binding]; other site 477641001170 active site 477641001171 CoA binding site [chemical binding]; other site 477641001172 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 477641001173 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 477641001174 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 477641001175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 477641001176 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 477641001177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001178 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641001179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641001180 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 477641001181 active site 477641001182 catalytic residues [active] 477641001183 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 477641001184 active site 477641001185 catalytic residues [active] 477641001186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 477641001187 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 477641001188 Ligand binding site; other site 477641001189 Putative Catalytic site; other site 477641001190 DXD motif; other site 477641001191 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 477641001192 active site 477641001193 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 477641001194 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 477641001195 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641001196 active site 477641001197 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641001198 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001199 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641001200 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001201 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340, 8157605; Product type e : enzyme 477641001202 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559340, 8157605; Product type e : enzyme 477641001203 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 477641001204 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 477641001205 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 477641001206 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 477641001207 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641001208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641001211 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641001212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641001215 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 477641001216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641001217 active site 477641001218 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 477641001219 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 477641001220 Probable Catalytic site; other site 477641001221 metal-binding site 477641001222 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 477641001223 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 477641001224 trimer interface [polypeptide binding]; other site 477641001225 CoA binding site [chemical binding]; other site 477641001226 active site 477641001227 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 477641001228 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 477641001229 Bacterial sugar transferase; Region: Bac_transf; pfam02397 477641001230 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 477641001231 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 477641001232 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 477641001233 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 477641001234 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641001235 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641001236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641001237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641001238 DNA binding residues [nucleotide binding] 477641001239 dimerization interface [polypeptide binding]; other site 477641001240 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 477641001241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641001242 dimerization interface [polypeptide binding]; other site 477641001243 DNA binding residues [nucleotide binding] 477641001244 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641001245 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 477641001246 Walker A/P-loop; other site 477641001247 ATP binding site [chemical binding]; other site 477641001248 Q-loop/lid; other site 477641001249 ABC transporter signature motif; other site 477641001250 Walker B; other site 477641001251 D-loop; other site 477641001252 H-loop/switch region; other site 477641001253 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 477641001254 active site 477641001255 catalytic residues [active] 477641001256 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 477641001257 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 477641001258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001259 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 477641001260 putative ADP-binding pocket [chemical binding]; other site 477641001261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001262 Acyltransferase family; Region: Acyl_transf_3; pfam01757 477641001263 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641001264 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641001265 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 477641001266 active site 477641001267 catalytic residues [active] 477641001268 AAA domain; Region: AAA_31; pfam13614 477641001269 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 477641001270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641001271 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 477641001272 active site 477641001273 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641001274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001275 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 477641001276 Bacterial sugar transferase; Region: Bac_transf; pfam02397 477641001277 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 477641001278 active site 477641001279 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 477641001280 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 477641001281 AAA domain; Region: AAA_18; pfam13238 477641001282 ligand-binding site [chemical binding]; other site 477641001283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641001284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641001285 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 477641001286 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641001287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641001288 Walker A/P-loop; other site 477641001289 ATP binding site [chemical binding]; other site 477641001290 Q-loop/lid; other site 477641001291 ABC transporter signature motif; other site 477641001292 Walker B; other site 477641001293 D-loop; other site 477641001294 H-loop/switch region; other site 477641001295 Predicted transcriptional regulators [Transcription]; Region: COG1695 477641001296 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 477641001297 hypothetical protein; Provisional; Region: PRK07945 477641001298 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 477641001299 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 477641001300 active site 477641001301 Predicted membrane protein [Function unknown]; Region: COG2259 477641001302 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 477641001303 active site 477641001304 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 477641001305 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 477641001306 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 477641001307 CGNR zinc finger; Region: zf-CGNR; pfam11706 477641001308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641001309 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 477641001310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 477641001311 Ligand Binding Site [chemical binding]; other site 477641001312 amino acid transporter; Region: 2A0306; TIGR00909 477641001313 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 477641001314 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 477641001315 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 477641001316 phosphate binding site [ion binding]; other site 477641001317 MarR family; Region: MarR; pfam01047 477641001318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641001319 active site 477641001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641001321 active site 477641001322 motif I; other site 477641001323 motif II; other site 477641001324 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 477641001325 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 477641001326 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 477641001327 putative active site [active] 477641001328 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 477641001329 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 477641001330 putative ADP-binding pocket [chemical binding]; other site 477641001331 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 477641001332 dimer interface [polypeptide binding]; other site 477641001333 active site 477641001334 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cd00287 477641001335 ATP binding site [chemical binding]; other site 477641001336 substrate binding site [chemical binding]; other site 477641001337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641001338 active site 477641001339 nucleotide binding site [chemical binding]; other site 477641001340 HIGH motif; other site 477641001341 KMSKS motif; other site 477641001342 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 477641001343 putative active site [active] 477641001344 Core-2/I-Branching enzyme; Region: Branch; pfam02485 477641001345 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 477641001346 metal ion-dependent adhesion site (MIDAS); other site 477641001347 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 477641001348 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641001349 NAD binding site [chemical binding]; other site 477641001350 putative substrate binding site 2 [chemical binding]; other site 477641001351 putative substrate binding site 1 [chemical binding]; other site 477641001352 active site 477641001353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641001354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 477641001355 dimerization interface [polypeptide binding]; other site 477641001356 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 477641001357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641001358 NAD(P) binding site [chemical binding]; other site 477641001359 active site 477641001360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641001361 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641001362 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 477641001363 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641001364 TM-ABC transporter signature motif; other site 477641001365 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641001366 TM-ABC transporter signature motif; other site 477641001367 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641001368 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 477641001369 Walker A/P-loop; other site 477641001370 ATP binding site [chemical binding]; other site 477641001371 Q-loop/lid; other site 477641001372 ABC transporter signature motif; other site 477641001373 Walker B; other site 477641001374 D-loop; other site 477641001375 H-loop/switch region; other site 477641001376 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641001377 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641001378 Walker A/P-loop; other site 477641001379 ATP binding site [chemical binding]; other site 477641001380 Q-loop/lid; other site 477641001381 ABC transporter signature motif; other site 477641001382 Walker B; other site 477641001383 D-loop; other site 477641001384 H-loop/switch region; other site 477641001385 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641001386 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 477641001387 prephenate dehydrogenase; Validated; Region: PRK08507 477641001388 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641001389 CoenzymeA binding site [chemical binding]; other site 477641001390 subunit interaction site [polypeptide binding]; other site 477641001391 PHB binding site; other site 477641001392 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 477641001393 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 477641001394 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 477641001395 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 477641001396 nucleoside/Zn binding site; other site 477641001397 dimer interface [polypeptide binding]; other site 477641001398 catalytic motif [active] 477641001399 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 477641001400 active site 477641001401 catalytic triad [active] 477641001402 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641001403 LGFP repeat; Region: LGFP; pfam08310 477641001404 LGFP repeat; Region: LGFP; pfam08310 477641001405 LGFP repeat; Region: LGFP; pfam08310 477641001406 LGFP repeat; Region: LGFP; pfam08310 477641001407 LGFP repeat; Region: LGFP; pfam08310 477641001408 LGFP repeat; Region: LGFP; pfam08310 477641001409 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641001410 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641001411 active site 477641001412 ATP binding site [chemical binding]; other site 477641001413 substrate binding site [chemical binding]; other site 477641001414 activation loop (A-loop); other site 477641001415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 477641001416 YceI-like domain; Region: YceI; pfam04264 477641001417 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 477641001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641001419 Walker A motif; other site 477641001420 ATP binding site [chemical binding]; other site 477641001421 Walker B motif; other site 477641001422 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641001423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641001424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641001425 hypothetical protein; Validated; Region: PRK00153 477641001426 recombination protein RecR; Reviewed; Region: recR; PRK00076 477641001427 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641001428 RecR protein; Region: RecR; pfam02132 477641001429 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 477641001430 putative active site [active] 477641001431 putative metal-binding site [ion binding]; other site 477641001432 tetramer interface [polypeptide binding]; other site 477641001433 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 477641001434 iron-sulfur cluster [ion binding]; other site 477641001435 [2Fe-2S] cluster binding site [ion binding]; other site 477641001436 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 477641001437 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 477641001438 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 477641001439 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641001440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641001441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641001442 dimer interface [polypeptide binding]; other site 477641001443 conserved gate region; other site 477641001444 putative PBP binding loops; other site 477641001445 ABC-ATPase subunit interface; other site 477641001446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641001447 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 477641001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641001449 dimer interface [polypeptide binding]; other site 477641001450 conserved gate region; other site 477641001451 ABC-ATPase subunit interface; other site 477641001452 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 477641001453 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641001454 Walker A/P-loop; other site 477641001455 ATP binding site [chemical binding]; other site 477641001456 Q-loop/lid; other site 477641001457 ABC transporter signature motif; other site 477641001458 Walker B; other site 477641001459 D-loop; other site 477641001460 H-loop/switch region; other site 477641001461 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641001462 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641001463 Walker A/P-loop; other site 477641001464 ATP binding site [chemical binding]; other site 477641001465 Q-loop/lid; other site 477641001466 ABC transporter signature motif; other site 477641001467 Walker B; other site 477641001468 D-loop; other site 477641001469 H-loop/switch region; other site 477641001470 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641001471 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641001472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641001473 dimerization interface [polypeptide binding]; other site 477641001474 putative DNA binding site [nucleotide binding]; other site 477641001475 putative Zn2+ binding site [ion binding]; other site 477641001476 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 477641001477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641001478 Pirin; Region: Pirin; pfam02678 477641001479 Pirin-related protein [General function prediction only]; Region: COG1741 477641001480 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 477641001481 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 477641001482 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641001483 classical (c) SDRs; Region: SDR_c; cd05233 477641001484 NAD(P) binding site [chemical binding]; other site 477641001485 active site 477641001486 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 477641001487 beta-galactosidase; Region: BGL; TIGR03356 477641001488 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 477641001489 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 477641001490 Walker A/P-loop; other site 477641001491 ATP binding site [chemical binding]; other site 477641001492 Q-loop/lid; other site 477641001493 ABC transporter signature motif; other site 477641001494 Walker B; other site 477641001495 D-loop; other site 477641001496 H-loop/switch region; other site 477641001497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 477641001498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641001499 dimer interface [polypeptide binding]; other site 477641001500 conserved gate region; other site 477641001501 putative PBP binding loops; other site 477641001502 ABC-ATPase subunit interface; other site 477641001503 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 477641001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641001505 ABC-ATPase subunit interface; other site 477641001506 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 477641001507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 477641001508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641001509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641001510 DNA binding site [nucleotide binding] 477641001511 domain linker motif; other site 477641001512 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 477641001513 putative dimerization interface [polypeptide binding]; other site 477641001514 putative ligand binding site [chemical binding]; other site 477641001515 Uncharacterized conserved protein [Function unknown]; Region: COG2308 477641001516 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 477641001517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 477641001518 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 477641001519 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 477641001520 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 477641001521 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 477641001522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641001523 ABC transporter; Region: ABC_tran_2; pfam12848 477641001524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641001525 2-isopropylmalate synthase; Validated; Region: PRK03739 477641001526 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 477641001527 active site 477641001528 catalytic residues [active] 477641001529 metal binding site [ion binding]; metal-binding site 477641001530 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 477641001531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641001532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641001533 non-specific DNA binding site [nucleotide binding]; other site 477641001534 salt bridge; other site 477641001535 sequence-specific DNA binding site [nucleotide binding]; other site 477641001536 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 477641001537 putative active site [active] 477641001538 catalytic site [active] 477641001539 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 477641001540 putative active site [active] 477641001541 catalytic site [active] 477641001542 aspartate kinase; Reviewed; Region: PRK06635 477641001543 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 477641001544 putative nucleotide binding site [chemical binding]; other site 477641001545 putative catalytic residues [active] 477641001546 putative Mg ion binding site [ion binding]; other site 477641001547 putative aspartate binding site [chemical binding]; other site 477641001548 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 477641001549 putative allosteric regulatory site; other site 477641001550 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 477641001551 putative allosteric regulatory residue; other site 477641001552 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 477641001553 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 477641001554 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641001555 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641001556 Domain of unknown function DUF21; Region: DUF21; pfam01595 477641001557 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 477641001558 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 477641001559 Domain of unknown function DUF21; Region: DUF21; pfam01595 477641001560 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 477641001561 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 477641001562 Transporter associated domain; Region: CorC_HlyC; smart01091 477641001563 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 477641001564 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 477641001565 putative active site [active] 477641001566 putative metal binding site [ion binding]; other site 477641001567 Yqey-like protein; Region: YqeY; cl17540 477641001568 Transglycosylase; Region: Transgly; pfam00912 477641001569 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 477641001570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 477641001571 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 477641001572 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 477641001573 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 477641001574 P loop; other site 477641001575 Nucleotide binding site [chemical binding]; other site 477641001576 DTAP/Switch II; other site 477641001577 Switch I; other site 477641001578 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 477641001579 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 477641001580 DTAP/Switch II; other site 477641001581 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 477641001582 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 477641001583 homotrimer interaction site [polypeptide binding]; other site 477641001584 putative active site [active] 477641001585 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 477641001586 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641001587 ligand binding site [chemical binding]; other site 477641001588 flexible hinge region; other site 477641001589 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 477641001590 putative switch regulator; other site 477641001591 non-specific DNA interactions [nucleotide binding]; other site 477641001592 DNA binding site [nucleotide binding] 477641001593 sequence specific DNA binding site [nucleotide binding]; other site 477641001594 putative cAMP binding site [chemical binding]; other site 477641001595 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 477641001596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 477641001597 minor groove reading motif; other site 477641001598 helix-hairpin-helix signature motif; other site 477641001599 substrate binding pocket [chemical binding]; other site 477641001600 active site 477641001601 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 477641001602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641001603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641001604 catalytic residues [active] 477641001605 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 477641001606 putative active site [active] 477641001607 putative CoA binding site [chemical binding]; other site 477641001608 nudix motif; other site 477641001609 metal binding site [ion binding]; metal-binding site 477641001610 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 477641001611 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 477641001612 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 477641001613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641001614 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 477641001615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641001616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641001617 non-specific DNA binding site [nucleotide binding]; other site 477641001618 salt bridge; other site 477641001619 sequence-specific DNA binding site [nucleotide binding]; other site 477641001620 acetyl-CoA synthetase; Provisional; Region: PRK00174 477641001621 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 477641001622 active site 477641001623 CoA binding site [chemical binding]; other site 477641001624 acyl-activating enzyme (AAE) consensus motif; other site 477641001625 AMP binding site [chemical binding]; other site 477641001626 acetate binding site [chemical binding]; other site 477641001627 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 477641001628 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 477641001629 CGNR zinc finger; Region: zf-CGNR; pfam11706 477641001630 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 477641001631 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 477641001632 HflX GTPase family; Region: HflX; cd01878 477641001633 G1 box; other site 477641001634 GTP/Mg2+ binding site [chemical binding]; other site 477641001635 Switch I region; other site 477641001636 G2 box; other site 477641001637 G3 box; other site 477641001638 Switch II region; other site 477641001639 G4 box; other site 477641001640 G5 box; other site 477641001641 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641001642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641001643 non-specific DNA binding site [nucleotide binding]; other site 477641001644 salt bridge; other site 477641001645 sequence-specific DNA binding site [nucleotide binding]; other site 477641001646 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641001647 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641001648 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641001649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641001650 Walker A/P-loop; other site 477641001651 ATP binding site [chemical binding]; other site 477641001652 Q-loop/lid; other site 477641001653 ABC transporter signature motif; other site 477641001654 Walker B; other site 477641001655 D-loop; other site 477641001656 H-loop/switch region; other site 477641001657 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 477641001658 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 477641001659 homodimer interface [polypeptide binding]; other site 477641001660 active site 477641001661 SAM binding site [chemical binding]; other site 477641001662 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 477641001663 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 477641001664 putative dimer interface [polypeptide binding]; other site 477641001665 active site pocket [active] 477641001666 putative cataytic base [active] 477641001667 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 477641001668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641001669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641001670 catalytic residue [active] 477641001671 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 477641001672 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 477641001673 Walker A/P-loop; other site 477641001674 ATP binding site [chemical binding]; other site 477641001675 Q-loop/lid; other site 477641001676 ABC transporter signature motif; other site 477641001677 Walker B; other site 477641001678 D-loop; other site 477641001679 H-loop/switch region; other site 477641001680 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 477641001681 cobalt transport protein CbiN; Provisional; Region: PRK02898 477641001682 cobalt transport protein CbiM; Validated; Region: PRK08319 477641001683 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 477641001684 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 477641001685 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 477641001686 catalytic triad [active] 477641001687 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 477641001688 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 477641001689 homodimer interface [polypeptide binding]; other site 477641001690 Walker A motif; other site 477641001691 ATP binding site [chemical binding]; other site 477641001692 hydroxycobalamin binding site [chemical binding]; other site 477641001693 Walker B motif; other site 477641001694 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 477641001695 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 477641001696 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 477641001697 metal ion-dependent adhesion site (MIDAS); other site 477641001698 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641001699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641001700 putative DNA binding site [nucleotide binding]; other site 477641001701 putative Zn2+ binding site [ion binding]; other site 477641001702 Putative ammonia monooxygenase; Region: AmoA; pfam05145 477641001703 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 477641001704 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 477641001705 PemK-like protein; Region: PemK; pfam02452 477641001706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641001707 active site 477641001708 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 477641001709 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 477641001710 active site 477641001711 cobyric acid synthase; Provisional; Region: PRK00784 477641001712 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641001713 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 477641001714 catalytic triad [active] 477641001715 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641001716 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 477641001717 putative acyl-acceptor binding pocket; other site 477641001718 PAS fold; Region: PAS_3; pfam08447 477641001719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641001720 heme pocket [chemical binding]; other site 477641001721 putative active site [active] 477641001722 ANTAR domain; Region: ANTAR; pfam03861 477641001723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 477641001724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641001725 DNA-binding site [nucleotide binding]; DNA binding site 477641001726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641001728 homodimer interface [polypeptide binding]; other site 477641001729 catalytic residue [active] 477641001730 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 477641001731 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 477641001732 active site 477641001733 catalytic residues [active] 477641001734 metal binding site [ion binding]; metal-binding site 477641001735 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 477641001736 active site 477641001737 putative homodimer interface [polypeptide binding]; other site 477641001738 SAM binding site [chemical binding]; other site 477641001739 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 477641001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641001741 S-adenosylmethionine binding site [chemical binding]; other site 477641001742 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 477641001743 active site 477641001744 SAM binding site [chemical binding]; other site 477641001745 homodimer interface [polypeptide binding]; other site 477641001746 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 477641001747 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 477641001748 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 477641001749 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 477641001750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641001751 motif II; other site 477641001752 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641001753 active site 477641001754 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641001755 G1 box; other site 477641001756 GTP/Mg2+ binding site [chemical binding]; other site 477641001757 G2 box; other site 477641001758 Switch I region; other site 477641001759 G3 box; other site 477641001760 Switch II region; other site 477641001761 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641001762 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641001763 G1 box; other site 477641001764 G1 box; other site 477641001765 GTP/Mg2+ binding site [chemical binding]; other site 477641001766 GTP/Mg2+ binding site [chemical binding]; other site 477641001767 G2 box; other site 477641001768 Switch I region; other site 477641001769 G3 box; other site 477641001770 Switch II region; other site 477641001771 G4 box; other site 477641001772 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 477641001773 active site 477641001774 SAM binding site [chemical binding]; other site 477641001775 homodimer interface [polypeptide binding]; other site 477641001776 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 477641001777 active site 477641001778 SAM binding site [chemical binding]; other site 477641001779 homodimer interface [polypeptide binding]; other site 477641001780 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 477641001781 Precorrin-8X methylmutase; Region: CbiC; pfam02570 477641001782 precorrin-3B synthase; Region: CobG; TIGR02435 477641001783 IncA protein; Region: IncA; pfam04156 477641001784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 477641001785 binding surface 477641001786 TPR motif; other site 477641001787 Hemerythrin-like domain; Region: Hr-like; cd12108 477641001788 Fe binding site [ion binding]; other site 477641001789 fructuronate transporter; Provisional; Region: PRK10034; cl15264 477641001790 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 477641001791 putative substrate binding site [chemical binding]; other site 477641001792 active site 477641001793 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 477641001794 Ca binding site [ion binding]; other site 477641001795 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 477641001796 Ca binding site [ion binding]; other site 477641001797 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 477641001798 cyanate transporter; Region: CynX; TIGR00896 477641001799 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 477641001800 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 477641001801 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 477641001802 VPS10 domain; Region: VPS10; smart00602 477641001803 Ubiquitin-like proteins; Region: UBQ; cl00155 477641001804 charged pocket; other site 477641001805 hydrophobic patch; other site 477641001806 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 477641001807 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 477641001808 homotrimer interface [polypeptide binding]; other site 477641001809 Walker A motif; other site 477641001810 GTP binding site [chemical binding]; other site 477641001811 Walker B motif; other site 477641001812 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641001813 catalytic core [active] 477641001814 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 477641001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641001816 motif II; other site 477641001817 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 477641001818 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 477641001819 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 477641001820 ATP binding site [chemical binding]; other site 477641001821 Walker A motif; other site 477641001822 hexamer interface [polypeptide binding]; other site 477641001823 Walker B motif; other site 477641001824 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 477641001825 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 477641001826 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 477641001827 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 477641001828 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 477641001829 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641001830 ATP binding site [chemical binding]; other site 477641001831 putative Mg++ binding site [ion binding]; other site 477641001832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641001833 nucleotide binding region [chemical binding]; other site 477641001834 ATP-binding site [chemical binding]; other site 477641001835 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 477641001836 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 477641001837 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 477641001838 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 477641001839 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 477641001840 active site 477641001841 interdomain interaction site; other site 477641001842 putative metal-binding site [ion binding]; other site 477641001843 nucleotide binding site [chemical binding]; other site 477641001844 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 477641001845 domain I; other site 477641001846 phosphate binding site [ion binding]; other site 477641001847 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 477641001848 domain II; other site 477641001849 domain III; other site 477641001850 nucleotide binding site [chemical binding]; other site 477641001851 DNA binding groove [nucleotide binding] 477641001852 catalytic site [active] 477641001853 domain IV; other site 477641001854 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 477641001855 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 477641001856 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 477641001857 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 477641001858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641001859 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 477641001860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641001861 S-adenosylmethionine binding site [chemical binding]; other site 477641001862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641001863 putative substrate translocation pore; other site 477641001864 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 477641001865 thymidylate kinase; Validated; Region: tmk; PRK00698 477641001866 TMP-binding site; other site 477641001867 ATP-binding site [chemical binding]; other site 477641001868 DNA polymerase III subunit delta'; Validated; Region: PRK07940 477641001869 DNA polymerase III subunit delta'; Validated; Region: PRK08485 477641001870 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 477641001871 putative active site [active] 477641001872 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 477641001873 RNAase interaction site [polypeptide binding]; other site 477641001874 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641001875 active site 477641001876 HTH-like domain; Region: HTH_21; pfam13276 477641001877 Integrase core domain; Region: rve; pfam00665 477641001878 Integrase core domain; Region: rve_3; pfam13683 477641001879 Transposase; Region: HTH_Tnp_1; cl17663 477641001880 Helix-turn-helix domain; Region: HTH_17; cl17695 477641001881 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 477641001882 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641001883 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 477641001884 Int/Topo IB signature motif; other site 477641001885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641001886 active site 477641001887 I-site; other site 477641001888 metal binding site [ion binding]; metal-binding site 477641001889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641001890 LGFP repeat; Region: LGFP; pfam08310 477641001891 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641001892 LGFP repeat; Region: LGFP; pfam08310 477641001893 LGFP repeat; Region: LGFP; pfam08310 477641001894 LGFP repeat; Region: LGFP; pfam08310 477641001895 LGFP repeat; Region: LGFP; pfam08310 477641001896 LGFP repeat; Region: LGFP; pfam08310 477641001897 AAA-like domain; Region: AAA_10; pfam12846 477641001898 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 477641001899 dimer interface [polypeptide binding]; other site 477641001900 substrate binding site [chemical binding]; other site 477641001901 metal binding sites [ion binding]; metal-binding site 477641001902 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 477641001903 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 477641001904 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 477641001905 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 477641001906 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 477641001907 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 477641001908 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 477641001909 Ligand Binding Site [chemical binding]; other site 477641001910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641001911 active site 477641001912 FtsH Extracellular; Region: FtsH_ext; pfam06480 477641001913 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 477641001914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641001915 Walker A motif; other site 477641001916 ATP binding site [chemical binding]; other site 477641001917 Walker B motif; other site 477641001918 arginine finger; other site 477641001919 Peptidase family M41; Region: Peptidase_M41; pfam01434 477641001920 GTP cyclohydrolase I; Provisional; Region: PLN03044 477641001921 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 477641001922 homodecamer interface [polypeptide binding]; other site 477641001923 active site 477641001924 putative catalytic site residues [active] 477641001925 zinc binding site [ion binding]; other site 477641001926 GTP-CH-I/GFRP interaction surface; other site 477641001927 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 477641001928 dihydropteroate synthase; Region: DHPS; TIGR01496 477641001929 substrate binding pocket [chemical binding]; other site 477641001930 dimer interface [polypeptide binding]; other site 477641001931 inhibitor binding site; inhibition site 477641001932 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 477641001933 homooctamer interface [polypeptide binding]; other site 477641001934 active site 477641001935 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 477641001936 catalytic center binding site [active] 477641001937 ATP binding site [chemical binding]; other site 477641001938 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 477641001939 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 477641001940 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 477641001941 Walker A/P-loop; other site 477641001942 ATP binding site [chemical binding]; other site 477641001943 Q-loop/lid; other site 477641001944 ABC transporter signature motif; other site 477641001945 Walker B; other site 477641001946 D-loop; other site 477641001947 H-loop/switch region; other site 477641001948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 477641001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641001950 dimer interface [polypeptide binding]; other site 477641001951 conserved gate region; other site 477641001952 ABC-ATPase subunit interface; other site 477641001953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 477641001954 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 477641001955 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 477641001956 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 477641001957 classical (c) SDRs; Region: SDR_c; cd05233 477641001958 NAD(P) binding site [chemical binding]; other site 477641001959 active site 477641001960 Rossmann-like domain; Region: Rossmann-like; pfam10727 477641001961 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 477641001962 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 477641001963 pantoate--beta-alanine ligase; Region: panC; TIGR00018 477641001964 active site 477641001965 nucleotide binding site [chemical binding]; other site 477641001966 HIGH motif; other site 477641001967 KMSKS motif; other site 477641001968 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 477641001969 tetramerization interface [polypeptide binding]; other site 477641001970 active site 477641001971 L-aspartate oxidase; Provisional; Region: PRK07804 477641001972 L-aspartate oxidase; Provisional; Region: PRK06175 477641001973 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 477641001974 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 477641001975 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 477641001976 dimerization interface [polypeptide binding]; other site 477641001977 active site 477641001978 pantothenate kinase; Reviewed; Region: PRK13318 477641001979 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 477641001980 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 477641001981 dimer interface [polypeptide binding]; other site 477641001982 putative anticodon binding site; other site 477641001983 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 477641001984 motif 1; other site 477641001985 dimer interface [polypeptide binding]; other site 477641001986 active site 477641001987 motif 2; other site 477641001988 motif 3; other site 477641001989 Lsr2; Region: Lsr2; pfam11774 477641001990 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 477641001991 Clp amino terminal domain; Region: Clp_N; pfam02861 477641001992 Clp amino terminal domain; Region: Clp_N; pfam02861 477641001993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641001994 Walker A motif; other site 477641001995 ATP binding site [chemical binding]; other site 477641001996 Walker B motif; other site 477641001997 arginine finger; other site 477641001998 UvrB/uvrC motif; Region: UVR; pfam02151 477641001999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641002000 Walker A motif; other site 477641002001 ATP binding site [chemical binding]; other site 477641002002 Walker B motif; other site 477641002003 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 477641002004 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 477641002005 minor groove reading motif; other site 477641002006 helix-hairpin-helix signature motif; other site 477641002007 substrate binding pocket [chemical binding]; other site 477641002008 active site 477641002009 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 477641002010 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 477641002011 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 477641002012 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 477641002013 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641002014 DNA repair protein RadA; Provisional; Region: PRK11823 477641002015 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641002016 Walker A motif; other site 477641002017 ATP binding site [chemical binding]; other site 477641002018 Walker B motif; other site 477641002019 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 477641002020 Protein of unknown function (DUF461); Region: DUF461; cl01071 477641002021 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 477641002022 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 477641002023 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 477641002024 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641002025 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641002026 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 477641002027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641002028 active site 477641002029 HIGH motif; other site 477641002030 nucleotide binding site [chemical binding]; other site 477641002031 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 477641002032 KMSKS motif; other site 477641002033 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 477641002034 tRNA binding surface [nucleotide binding]; other site 477641002035 anticodon binding site; other site 477641002036 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 477641002037 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 477641002038 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 477641002039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 477641002040 homotrimer interaction site [polypeptide binding]; other site 477641002041 putative active site [active] 477641002042 Protein of unknown function (DUF445); Region: DUF445; pfam04286 477641002043 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 477641002044 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 477641002045 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 477641002046 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 477641002047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641002048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641002049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641002050 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 477641002051 Dodecin; Region: Dodecin; pfam07311 477641002052 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 477641002053 iron-sulfur cluster [ion binding]; other site 477641002054 [2Fe-2S] cluster binding site [ion binding]; other site 477641002055 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 477641002056 Predicted permeases [General function prediction only]; Region: RarD; COG2962 477641002057 EamA-like transporter family; Region: EamA; pfam00892 477641002058 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 477641002059 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 477641002060 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641002061 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 477641002062 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 477641002063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641002064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002065 Walker A/P-loop; other site 477641002066 ATP binding site [chemical binding]; other site 477641002067 Q-loop/lid; other site 477641002068 ABC transporter signature motif; other site 477641002069 Walker B; other site 477641002070 D-loop; other site 477641002071 H-loop/switch region; other site 477641002072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641002073 sucrose-phosphate phosphatase subfamily; Region: SPP-subfamily; TIGR01482 477641002074 active site 477641002075 motif I; other site 477641002076 motif II; other site 477641002077 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 477641002078 threonine synthase; Validated; Region: PRK07591 477641002079 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 477641002080 homodimer interface [polypeptide binding]; other site 477641002081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641002082 catalytic residue [active] 477641002083 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 477641002084 DNA-binding site [nucleotide binding]; DNA binding site 477641002085 RNA-binding motif; other site 477641002086 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 477641002087 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 477641002088 ring oligomerisation interface [polypeptide binding]; other site 477641002089 ATP/Mg binding site [chemical binding]; other site 477641002090 stacking interactions; other site 477641002091 hinge regions; other site 477641002092 Protein of unknown function DUF72; Region: DUF72; pfam01904 477641002093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641002094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641002095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641002096 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641002097 active site 477641002098 metal binding site [ion binding]; metal-binding site 477641002099 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 477641002100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 477641002101 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 477641002102 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 477641002103 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 477641002104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641002105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641002106 non-specific DNA binding site [nucleotide binding]; other site 477641002107 salt bridge; other site 477641002108 sequence-specific DNA binding site [nucleotide binding]; other site 477641002109 Cupin domain; Region: Cupin_2; pfam07883 477641002110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641002111 dimer interface [polypeptide binding]; other site 477641002112 conserved gate region; other site 477641002113 putative PBP binding loops; other site 477641002114 ABC-ATPase subunit interface; other site 477641002115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641002116 DNA binding site [nucleotide binding] 477641002117 Int/Topo IB signature motif; other site 477641002118 active site 477641002119 AAA domain; Region: AAA_30; pfam13604 477641002120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 477641002121 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 477641002122 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 477641002123 Multicopper oxidase; Region: Cu-oxidase; pfam00394 477641002124 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 477641002125 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641002126 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641002127 active site residue [active] 477641002128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 477641002129 Rhodanese-like domain; Region: Rhodanese; pfam00581 477641002130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641002131 active site residue [active] 477641002132 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641002133 active site residue [active] 477641002134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641002135 active site residue [active] 477641002136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641002137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 477641002138 active site residue [active] 477641002139 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 477641002140 putative homotetramer interface [polypeptide binding]; other site 477641002141 putative homodimer interface [polypeptide binding]; other site 477641002142 putative allosteric switch controlling residues; other site 477641002143 putative metal binding site [ion binding]; other site 477641002144 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 477641002145 Domain of unknown function (DUF955); Region: DUF955; pfam06114 477641002146 Helix-turn-helix domain; Region: HTH_17; pfam12728 477641002147 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 477641002148 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 477641002149 RES domain; Region: RES; cl02411 477641002150 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 477641002151 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 477641002152 metal binding site [ion binding]; metal-binding site 477641002153 substrate binding pocket [chemical binding]; other site 477641002154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641002155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641002156 NAD(P) binding site [chemical binding]; other site 477641002157 active site 477641002158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641002159 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 477641002160 Scramblase; Region: Scramblase; pfam03803 477641002161 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 477641002162 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 477641002163 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 477641002164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641002165 metabolite-proton symporter; Region: 2A0106; TIGR00883 477641002166 putative substrate translocation pore; other site 477641002167 AAA ATPase domain; Region: AAA_16; pfam13191 477641002168 Walker A motif; other site 477641002169 ATP binding site [chemical binding]; other site 477641002170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641002171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641002172 DNA binding residues [nucleotide binding] 477641002173 dimerization interface [polypeptide binding]; other site 477641002174 PspC domain; Region: PspC; pfam04024 477641002175 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 477641002176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 477641002177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 477641002178 ATP-binding site [chemical binding]; other site 477641002179 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 477641002180 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 477641002181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641002182 ATP binding site [chemical binding]; other site 477641002183 putative Mg++ binding site [ion binding]; other site 477641002184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641002185 nucleotide binding region [chemical binding]; other site 477641002186 ATP-binding site [chemical binding]; other site 477641002187 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 477641002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641002189 S-adenosylmethionine binding site [chemical binding]; other site 477641002190 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 477641002191 WYL domain; Region: WYL; pfam13280 477641002192 AMP-binding domain protein; Validated; Region: PRK08315 477641002193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641002194 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 477641002195 acyl-activating enzyme (AAE) consensus motif; other site 477641002196 putative AMP binding site [chemical binding]; other site 477641002197 putative active site [active] 477641002198 putative CoA binding site [chemical binding]; other site 477641002199 Integrase core domain; Region: rve; pfam00665 477641002200 Integrase core domain; Region: rve_3; pfam13683 477641002201 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 477641002202 DNA-binding site [nucleotide binding]; DNA binding site 477641002203 RNA-binding motif; other site 477641002204 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 477641002205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641002206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641002207 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 477641002208 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641002209 MarR family; Region: MarR; pfam01047 477641002210 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641002212 putative substrate translocation pore; other site 477641002213 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 477641002214 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 477641002215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641002216 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641002217 active site 477641002218 catalytic tetrad [active] 477641002219 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 477641002220 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 477641002221 active site 2 [active] 477641002222 active site 1 [active] 477641002223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 477641002224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641002225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002226 Walker A/P-loop; other site 477641002227 ATP binding site [chemical binding]; other site 477641002228 Q-loop/lid; other site 477641002229 ABC transporter signature motif; other site 477641002230 Walker B; other site 477641002231 D-loop; other site 477641002232 H-loop/switch region; other site 477641002233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002234 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641002235 Walker A/P-loop; other site 477641002236 ATP binding site [chemical binding]; other site 477641002237 Q-loop/lid; other site 477641002238 ABC transporter signature motif; other site 477641002239 Walker B; other site 477641002240 D-loop; other site 477641002241 H-loop/switch region; other site 477641002242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641002243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641002244 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641002245 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641002246 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 477641002247 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641002248 Walker A/P-loop; other site 477641002249 ATP binding site [chemical binding]; other site 477641002250 Q-loop/lid; other site 477641002251 ABC transporter signature motif; other site 477641002252 Walker B; other site 477641002253 D-loop; other site 477641002254 H-loop/switch region; other site 477641002255 PAS domain S-box; Region: sensory_box; TIGR00229 477641002256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641002257 putative active site [active] 477641002258 heme pocket [chemical binding]; other site 477641002259 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641002260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641002261 metal binding site [ion binding]; metal-binding site 477641002262 active site 477641002263 I-site; other site 477641002264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641002265 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 477641002266 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 477641002267 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 477641002268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641002269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641002270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002271 Walker A/P-loop; other site 477641002272 ATP binding site [chemical binding]; other site 477641002273 Q-loop/lid; other site 477641002274 ABC transporter signature motif; other site 477641002275 Walker B; other site 477641002276 D-loop; other site 477641002277 H-loop/switch region; other site 477641002278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641002279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641002280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002281 Walker A/P-loop; other site 477641002282 ATP binding site [chemical binding]; other site 477641002283 Q-loop/lid; other site 477641002284 ABC transporter signature motif; other site 477641002285 Walker B; other site 477641002286 D-loop; other site 477641002287 H-loop/switch region; other site 477641002288 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 477641002289 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 477641002290 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 477641002291 active site 477641002292 dimer interface [polypeptide binding]; other site 477641002293 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 477641002294 Ligand Binding Site [chemical binding]; other site 477641002295 Molecular Tunnel; other site 477641002296 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641002297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641002298 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 477641002299 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 477641002300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641002301 NAD(P) binding site [chemical binding]; other site 477641002302 active site 477641002303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641002304 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641002305 YcaO-like family; Region: YcaO; pfam02624 477641002306 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 477641002307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641002308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641002309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641002310 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641002311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641002312 S-adenosylmethionine binding site [chemical binding]; other site 477641002313 HD domain; Region: HD_3; cl17350 477641002314 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 477641002315 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 477641002316 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641002317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641002318 catalytic residue [active] 477641002319 citrate synthase 2; Provisional; Region: PRK12350 477641002320 Citrate synthase; Region: Citrate_synt; pfam00285 477641002321 oxalacetate binding site [chemical binding]; other site 477641002322 citrylCoA binding site [chemical binding]; other site 477641002323 coenzyme A binding site [chemical binding]; other site 477641002324 catalytic triad [active] 477641002325 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 477641002326 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 477641002327 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 477641002328 enterobactin exporter EntS; Provisional; Region: PRK10489 477641002329 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 477641002330 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 477641002331 ligand binding site; other site 477641002332 oligomer interface; other site 477641002333 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 477641002334 dimer interface [polypeptide binding]; other site 477641002335 N-terminal domain interface [polypeptide binding]; other site 477641002336 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 477641002337 Fe-S cluster binding site [ion binding]; other site 477641002338 active site 477641002339 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 477641002340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002341 Walker A/P-loop; other site 477641002342 ATP binding site [chemical binding]; other site 477641002343 Q-loop/lid; other site 477641002344 ABC transporter signature motif; other site 477641002345 Walker B; other site 477641002346 D-loop; other site 477641002347 H-loop/switch region; other site 477641002348 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 477641002349 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 477641002350 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 477641002351 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 477641002352 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 477641002353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641002354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641002355 homodimer interface [polypeptide binding]; other site 477641002356 catalytic residue [active] 477641002357 ferredoxin-NADP+ reductase; Region: PLN02852 477641002358 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641002359 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 477641002360 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 477641002361 putative DNA binding site [nucleotide binding]; other site 477641002362 catalytic residue [active] 477641002363 putative H2TH interface [polypeptide binding]; other site 477641002364 putative catalytic residues [active] 477641002365 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 477641002366 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 477641002367 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 477641002368 DNA photolyase; Region: DNA_photolyase; pfam00875 477641002369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641002370 Coenzyme A binding pocket [chemical binding]; other site 477641002371 Predicted membrane protein [Function unknown]; Region: COG2364 477641002372 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 477641002373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641002374 DNA-binding site [nucleotide binding]; DNA binding site 477641002375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 477641002376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641002377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641002378 homodimer interface [polypeptide binding]; other site 477641002379 catalytic residue [active] 477641002380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641002381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641002382 active site 477641002383 phosphorylation site [posttranslational modification] 477641002384 intermolecular recognition site; other site 477641002385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641002386 DNA binding residues [nucleotide binding] 477641002387 dimerization interface [polypeptide binding]; other site 477641002388 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 477641002389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641002390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641002391 DNA binding site [nucleotide binding] 477641002392 domain linker motif; other site 477641002393 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 477641002394 ligand binding site [chemical binding]; other site 477641002395 dimerization interface [polypeptide binding]; other site 477641002396 MULE transposase domain; Region: MULE; pfam10551 477641002397 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 477641002398 active site 477641002399 catalytic residues [active] 477641002400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641002401 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641002402 TM-ABC transporter signature motif; other site 477641002403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641002404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641002405 TM-ABC transporter signature motif; other site 477641002406 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641002407 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641002408 Walker A/P-loop; other site 477641002409 ATP binding site [chemical binding]; other site 477641002410 Q-loop/lid; other site 477641002411 ABC transporter signature motif; other site 477641002412 Walker B; other site 477641002413 D-loop; other site 477641002414 H-loop/switch region; other site 477641002415 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641002416 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 477641002417 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 477641002418 putative ligand binding site [chemical binding]; other site 477641002419 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 477641002420 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 477641002421 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 477641002422 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 477641002423 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 477641002424 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 477641002425 serine/threonine protein kinase; Provisional; Region: PRK11768 477641002426 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641002427 CoenzymeA binding site [chemical binding]; other site 477641002428 subunit interaction site [polypeptide binding]; other site 477641002429 PHB binding site; other site 477641002430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641002431 active site 477641002432 metal binding site [ion binding]; metal-binding site 477641002433 Evidence 4 : Homologs of previously reported genes of unknown function 477641002434 Evidence 4 : Homologs of previously reported genes of unknown function 477641002435 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 477641002436 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 477641002437 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 477641002438 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 477641002439 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641002440 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 477641002441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641002442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641002443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641002444 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 477641002445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002446 Walker A/P-loop; other site 477641002447 ATP binding site [chemical binding]; other site 477641002448 Q-loop/lid; other site 477641002449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002450 ABC transporter signature motif; other site 477641002451 Walker B; other site 477641002452 D-loop; other site 477641002453 H-loop/switch region; other site 477641002454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002455 Walker A/P-loop; other site 477641002456 ATP binding site [chemical binding]; other site 477641002457 Q-loop/lid; other site 477641002458 ABC transporter signature motif; other site 477641002459 Walker B; other site 477641002460 D-loop; other site 477641002461 H-loop/switch region; other site 477641002462 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641002463 MarR family; Region: MarR_2; pfam12802 477641002464 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 477641002465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641002466 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 477641002467 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 477641002468 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 477641002469 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 477641002470 CoA-transferase family III; Region: CoA_transf_3; pfam02515 477641002471 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 477641002472 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 477641002473 active site 477641002474 tetramer interface; other site 477641002475 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 477641002476 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 477641002477 dimer interface [polypeptide binding]; other site 477641002478 putative functional site; other site 477641002479 putative MPT binding site; other site 477641002480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641002481 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 477641002482 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 477641002483 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 477641002484 LGFP repeat; Region: LGFP; pfam08310 477641002485 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641002486 LGFP repeat; Region: LGFP; pfam08310 477641002487 LGFP repeat; Region: LGFP; pfam08310 477641002488 LGFP repeat; Region: LGFP; pfam08310 477641002489 LGFP repeat; Region: LGFP; pfam08310 477641002490 enoyl-CoA hydratase; Provisional; Region: PRK07511 477641002491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641002492 substrate binding site [chemical binding]; other site 477641002493 oxyanion hole (OAH) forming residues; other site 477641002494 trimer interface [polypeptide binding]; other site 477641002495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641002496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641002497 putative substrate translocation pore; other site 477641002498 MarR family; Region: MarR_2; cl17246 477641002499 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 477641002500 Predicted methyltransferases [General function prediction only]; Region: COG0313 477641002501 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 477641002502 putative SAM binding site [chemical binding]; other site 477641002503 putative homodimer interface [polypeptide binding]; other site 477641002504 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641002505 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641002506 putative active site [active] 477641002507 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 477641002508 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 477641002509 oligomer interface [polypeptide binding]; other site 477641002510 metal binding site [ion binding]; metal-binding site 477641002511 metal binding site [ion binding]; metal-binding site 477641002512 putative Cl binding site [ion binding]; other site 477641002513 basic sphincter; other site 477641002514 hydrophobic gate; other site 477641002515 periplasmic entrance; other site 477641002516 amino acid transporter; Region: 2A0306; TIGR00909 477641002517 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 477641002518 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 477641002519 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 477641002520 active site 477641002521 HIGH motif; other site 477641002522 KMSKS motif; other site 477641002523 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 477641002524 tRNA binding surface [nucleotide binding]; other site 477641002525 anticodon binding site; other site 477641002526 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 477641002527 active site 477641002528 Domain of unknown function (DUF348); Region: DUF348; pfam03990 477641002529 Domain of unknown function (DUF348); Region: DUF348; pfam03990 477641002530 G5 domain; Region: G5; pfam07501 477641002531 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 477641002532 N-acetyl-D-glucosamine binding site [chemical binding]; other site 477641002533 catalytic residue [active] 477641002534 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 477641002535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641002536 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 477641002537 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 477641002538 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 477641002539 Substrate binding site; other site 477641002540 Mg++ binding site; other site 477641002541 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 477641002542 active site 477641002543 substrate binding site [chemical binding]; other site 477641002544 CoA binding site [chemical binding]; other site 477641002545 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 477641002546 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 477641002547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641002548 active site 477641002549 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 477641002550 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 477641002551 5S rRNA interface [nucleotide binding]; other site 477641002552 CTC domain interface [polypeptide binding]; other site 477641002553 L16 interface [polypeptide binding]; other site 477641002554 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 477641002555 putative active site [active] 477641002556 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 477641002557 active site 477641002558 catalytic residues [active] 477641002559 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 477641002560 Bacterial sugar transferase; Region: Bac_transf; pfam02397 477641002561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641002562 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 477641002563 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 477641002564 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641002565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641002566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 477641002567 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 477641002568 putative active site [active] 477641002569 putative metal binding site [ion binding]; other site 477641002570 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 477641002571 Chain length determinant protein; Region: Wzz; pfam02706 477641002572 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 477641002573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641002574 active site 477641002575 nucleotide binding site [chemical binding]; other site 477641002576 HIGH motif; other site 477641002577 KMSKS motif; other site 477641002578 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 477641002579 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 477641002580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641002581 ATP binding site [chemical binding]; other site 477641002582 putative Mg++ binding site [ion binding]; other site 477641002583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641002584 nucleotide binding region [chemical binding]; other site 477641002585 ATP-binding site [chemical binding]; other site 477641002586 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 477641002587 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 477641002588 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 477641002589 homodimer interface [polypeptide binding]; other site 477641002590 metal binding site [ion binding]; metal-binding site 477641002591 enolase; Provisional; Region: eno; PRK00077 477641002592 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 477641002593 dimer interface [polypeptide binding]; other site 477641002594 metal binding site [ion binding]; metal-binding site 477641002595 substrate binding pocket [chemical binding]; other site 477641002596 Septum formation initiator; Region: DivIC; cl17659 477641002597 Protein of unknown function (DUF501); Region: DUF501; cl00652 477641002598 exopolyphosphatase; Region: exo_poly_only; TIGR03706 477641002599 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 477641002600 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 477641002601 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 477641002602 Fe-S cluster binding site [ion binding]; other site 477641002603 DNA binding site [nucleotide binding] 477641002604 active site 477641002605 Bax inhibitor 1 like; Region: BaxI_1; cl17691 477641002606 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 477641002607 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641002608 dimer interface [polypeptide binding]; other site 477641002609 active site 477641002610 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 477641002611 active site 477641002612 catalytic triad [active] 477641002613 oxyanion hole [active] 477641002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 477641002615 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 477641002616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 477641002617 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 477641002618 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 477641002619 metal ion-dependent adhesion site (MIDAS); other site 477641002620 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 477641002621 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 477641002622 threonine dehydratase; Provisional; Region: PRK08198 477641002623 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 477641002624 tetramer interface [polypeptide binding]; other site 477641002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641002626 catalytic residue [active] 477641002627 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 477641002628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002629 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 477641002630 Walker A/P-loop; other site 477641002631 ATP binding site [chemical binding]; other site 477641002632 Q-loop/lid; other site 477641002633 ABC transporter signature motif; other site 477641002634 Walker B; other site 477641002635 D-loop; other site 477641002636 H-loop/switch region; other site 477641002637 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641002638 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 477641002639 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 477641002640 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 477641002641 active site 477641002642 Zn binding site [ion binding]; other site 477641002643 RNHCP domain; Region: RNHCP; pfam12647 477641002644 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 477641002645 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 477641002646 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 477641002647 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 477641002648 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 477641002649 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 477641002650 catalytic residues [active] 477641002651 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 477641002652 potential frameshift: common BLAST hit: gi|331697239|ref|YP_004333478.1| geranylgeranyl reductase 477641002653 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 477641002654 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 477641002655 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 477641002656 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 477641002657 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 477641002658 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 477641002659 catalytic residue [active] 477641002660 putative FPP diphosphate binding site; other site 477641002661 putative FPP binding hydrophobic cleft; other site 477641002662 dimer interface [polypeptide binding]; other site 477641002663 putative IPP diphosphate binding site; other site 477641002664 Predicted transcriptional regulators [Transcription]; Region: COG1695 477641002665 Transcriptional regulator PadR-like family; Region: PadR; cl17335 477641002666 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641002667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641002668 Walker A/P-loop; other site 477641002669 ATP binding site [chemical binding]; other site 477641002670 Q-loop/lid; other site 477641002671 ABC transporter signature motif; other site 477641002672 Walker B; other site 477641002673 D-loop; other site 477641002674 H-loop/switch region; other site 477641002675 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641002676 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 477641002677 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 477641002678 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 477641002679 putative active site [active] 477641002680 PhoH-like protein; Region: PhoH; pfam02562 477641002681 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641002682 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 477641002683 FHIPEP family; Region: FHIPEP; pfam00771 477641002684 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 477641002685 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 477641002686 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 477641002687 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 477641002688 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 477641002689 flagellar motor switch protein FliN; Region: fliN; TIGR02480 477641002690 Flagellar motor switch protein FliM; Region: FliM; pfam02154 477641002691 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 477641002692 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 477641002693 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 477641002694 ligand binding site [chemical binding]; other site 477641002695 flagellar motor protein MotA; Validated; Region: PRK08124 477641002696 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 477641002697 Flagellar protein (FlbD); Region: FlbD; pfam06289 477641002698 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 477641002699 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 477641002700 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 477641002701 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 477641002702 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 477641002703 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 477641002704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641002705 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641002706 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 477641002707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 477641002708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 477641002709 catalytic residue [active] 477641002710 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 477641002711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 477641002712 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 477641002713 Walker A motif/ATP binding site; other site 477641002714 Walker B motif; other site 477641002715 Flagellar assembly protein FliH; Region: FliH; pfam02108 477641002716 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 477641002717 FliG C-terminal domain; Region: FliG_C; pfam01706 477641002718 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 477641002719 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 477641002720 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 477641002721 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 477641002722 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 477641002723 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 477641002724 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 477641002725 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 477641002726 Flagellar protein FliS; Region: FliS; cl00654 477641002727 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 477641002728 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 477641002729 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 477641002730 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 477641002731 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 477641002732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641002733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641002734 DNA binding residues [nucleotide binding] 477641002735 FlgN protein; Region: FlgN; pfam05130 477641002736 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 477641002737 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 477641002738 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 477641002739 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 477641002740 Global regulator protein family; Region: CsrA; pfam02599 477641002741 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 477641002742 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641002743 NlpC/P60 family; Region: NLPC_P60; cl17555 477641002744 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 477641002745 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 477641002746 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 477641002747 dimer interface [polypeptide binding]; other site 477641002748 active site 477641002749 citrylCoA binding site [chemical binding]; other site 477641002750 NADH binding [chemical binding]; other site 477641002751 cationic pore residues; other site 477641002752 oxalacetate/citrate binding site [chemical binding]; other site 477641002753 coenzyme A binding site [chemical binding]; other site 477641002754 catalytic triad [active] 477641002755 fumarate hydratase; Reviewed; Region: fumC; PRK00485 477641002756 Class II fumarases; Region: Fumarase_classII; cd01362 477641002757 active site 477641002758 tetramer interface [polypeptide binding]; other site 477641002759 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 477641002760 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 477641002761 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 477641002762 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 477641002763 putative active site [active] 477641002764 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 477641002765 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 477641002766 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 477641002767 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 477641002768 generic binding surface II; other site 477641002769 generic binding surface I; other site 477641002770 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 477641002771 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 477641002772 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 477641002773 RmuC family; Region: RmuC; pfam02646 477641002774 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641002775 active site 477641002776 metal binding site [ion binding]; metal-binding site 477641002777 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 477641002778 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 477641002779 active site 477641002780 DNA binding site [nucleotide binding] 477641002781 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 477641002782 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 477641002783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641002784 AlkA N-terminal domain; Region: AlkA_N; cl05528 477641002785 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 477641002786 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641002787 minor groove reading motif; other site 477641002788 helix-hairpin-helix signature motif; other site 477641002789 short chain dehydrogenase; Validated; Region: PRK08264 477641002790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641002791 NAD(P) binding site [chemical binding]; other site 477641002792 active site 477641002793 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641002794 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641002795 Walker A/P-loop; other site 477641002796 ATP binding site [chemical binding]; other site 477641002797 Q-loop/lid; other site 477641002798 ABC transporter signature motif; other site 477641002799 Walker B; other site 477641002800 D-loop; other site 477641002801 H-loop/switch region; other site 477641002802 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 477641002803 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 477641002804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641002805 Histidine kinase; Region: HisKA_3; pfam07730 477641002806 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 477641002807 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641002808 ATP binding site [chemical binding]; other site 477641002809 Mg2+ binding site [ion binding]; other site 477641002810 G-X-G motif; other site 477641002811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641002813 active site 477641002814 phosphorylation site [posttranslational modification] 477641002815 intermolecular recognition site; other site 477641002816 dimerization interface [polypeptide binding]; other site 477641002817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641002818 DNA binding residues [nucleotide binding] 477641002819 dimerization interface [polypeptide binding]; other site 477641002820 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641002821 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641002822 active site 477641002823 GTP-binding protein YchF; Reviewed; Region: PRK09601 477641002824 YchF GTPase; Region: YchF; cd01900 477641002825 G1 box; other site 477641002826 GTP/Mg2+ binding site [chemical binding]; other site 477641002827 Switch I region; other site 477641002828 G2 box; other site 477641002829 Switch II region; other site 477641002830 G3 box; other site 477641002831 G4 box; other site 477641002832 G5 box; other site 477641002833 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 477641002834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641002835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641002836 sequence-specific DNA binding site [nucleotide binding]; other site 477641002837 salt bridge; other site 477641002838 short chain dehydrogenase; Provisional; Region: PRK05854 477641002839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641002840 NAD(P) binding site [chemical binding]; other site 477641002841 active site 477641002842 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 477641002843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641002844 substrate binding site [chemical binding]; other site 477641002845 oxyanion hole (OAH) forming residues; other site 477641002846 trimer interface [polypeptide binding]; other site 477641002847 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641002848 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641002849 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 477641002850 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641002851 putative NAD(P) binding site [chemical binding]; other site 477641002852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641002853 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 477641002854 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 477641002855 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 477641002856 active site 477641002857 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641002858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641002859 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 477641002860 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 477641002861 putative active site [active] 477641002862 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 477641002863 putative ADP-binding pocket [chemical binding]; other site 477641002864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641002865 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 477641002866 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 477641002867 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 477641002868 putative active site [active] 477641002869 putative NTP binding site [chemical binding]; other site 477641002870 putative nucleic acid binding site [nucleotide binding]; other site 477641002871 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 477641002872 active site 477641002873 catalytic residues [active] 477641002874 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 477641002875 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641002876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641002877 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641002878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641002879 putative substrate translocation pore; other site 477641002880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641002881 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 477641002882 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 477641002883 active site 477641002884 purine riboside binding site [chemical binding]; other site 477641002885 Protein of unknown function (DUF419); Region: DUF419; cl15265 477641002886 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641002887 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 477641002888 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 477641002889 active site 477641002890 catalytic triad [active] 477641002891 oxyanion hole [active] 477641002892 Protein of unknown function, DUF393; Region: DUF393; pfam04134 477641002893 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641002894 putative catalytic site [active] 477641002895 putative phosphate binding site [ion binding]; other site 477641002896 putative metal binding site [ion binding]; other site 477641002897 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641002898 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 477641002899 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 477641002900 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 477641002901 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 477641002902 L-aspartate oxidase; Provisional; Region: PRK06175 477641002903 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 477641002904 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 477641002905 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 477641002906 putative Iron-sulfur protein interface [polypeptide binding]; other site 477641002907 proximal heme binding site [chemical binding]; other site 477641002908 distal heme binding site [chemical binding]; other site 477641002909 putative dimer interface [polypeptide binding]; other site 477641002910 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 477641002911 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 477641002912 Moco binding site; other site 477641002913 metal coordination site [ion binding]; other site 477641002914 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 477641002915 FAD binding pocket [chemical binding]; other site 477641002916 conserved FAD binding motif [chemical binding]; other site 477641002917 phosphate binding motif [ion binding]; other site 477641002918 beta-alpha-beta structure motif; other site 477641002919 NAD binding pocket [chemical binding]; other site 477641002920 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 477641002921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 477641002922 siderophore binding site; other site 477641002923 hydroperoxidase II; Provisional; Region: katE; PRK11249 477641002924 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 477641002925 heme binding pocket [chemical binding]; other site 477641002926 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 477641002927 domain interactions; other site 477641002928 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 477641002929 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 477641002930 short chain dehydrogenase; Provisional; Region: PRK07326 477641002931 classical (c) SDRs; Region: SDR_c; cd05233 477641002932 NAD(P) binding site [chemical binding]; other site 477641002933 active site 477641002934 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 477641002935 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 477641002936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641002937 Coenzyme A binding pocket [chemical binding]; other site 477641002938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641002939 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641002940 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641002941 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 477641002942 aromatic arch; other site 477641002943 DCoH dimer interaction site [polypeptide binding]; other site 477641002944 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 477641002945 DCoH tetramer interaction site [polypeptide binding]; other site 477641002946 substrate binding site [chemical binding]; other site 477641002947 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 477641002948 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 477641002949 Active Sites [active] 477641002950 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 477641002951 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 477641002952 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 477641002953 Predicted transcriptional regulator [Transcription]; Region: COG1959 477641002954 Transcriptional regulator; Region: Rrf2; pfam02082 477641002955 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 477641002956 active site 477641002957 8-oxo-dGMP binding site [chemical binding]; other site 477641002958 nudix motif; other site 477641002959 metal binding site [ion binding]; metal-binding site 477641002960 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641002961 putative active site [active] 477641002962 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 477641002963 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 477641002964 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 477641002965 CsbD-like; Region: CsbD; pfam05532 477641002966 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 477641002967 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 477641002968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641002969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641002970 dimer interface [polypeptide binding]; other site 477641002971 conserved gate region; other site 477641002972 putative PBP binding loops; other site 477641002973 ABC-ATPase subunit interface; other site 477641002974 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 477641002975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641002976 ABC-ATPase subunit interface; other site 477641002977 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641002978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641002979 Walker A/P-loop; other site 477641002980 ATP binding site [chemical binding]; other site 477641002981 Q-loop/lid; other site 477641002982 ABC transporter signature motif; other site 477641002983 Walker B; other site 477641002984 D-loop; other site 477641002985 H-loop/switch region; other site 477641002986 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641002987 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 477641002988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641002989 Walker A/P-loop; other site 477641002990 ATP binding site [chemical binding]; other site 477641002991 Q-loop/lid; other site 477641002992 ABC transporter signature motif; other site 477641002993 Walker B; other site 477641002994 D-loop; other site 477641002995 H-loop/switch region; other site 477641002996 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 477641002997 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 477641002998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641002999 Coenzyme A binding pocket [chemical binding]; other site 477641003000 Ferredoxin [Energy production and conversion]; Region: COG1146 477641003001 4Fe-4S binding domain; Region: Fer4; pfam00037 477641003002 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 477641003003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641003004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641003005 homodimer interface [polypeptide binding]; other site 477641003006 catalytic residue [active] 477641003007 Cupin; Region: Cupin_6; pfam12852 477641003008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641003009 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641003010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641003011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003012 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641003013 NAD(P) binding site [chemical binding]; other site 477641003014 active site 477641003015 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 477641003016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641003017 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 477641003018 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 477641003019 putative trimer interface [polypeptide binding]; other site 477641003020 putative CoA binding site [chemical binding]; other site 477641003021 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 477641003022 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 477641003023 metal binding site [ion binding]; metal-binding site 477641003024 putative dimer interface [polypeptide binding]; other site 477641003025 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 477641003026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 477641003027 hydrophobic ligand binding site; other site 477641003028 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 477641003029 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 477641003030 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 477641003031 Moco binding site; other site 477641003032 metal coordination site [ion binding]; other site 477641003033 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 477641003034 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 477641003035 Ligand binding site; other site 477641003036 Putative Catalytic site; other site 477641003037 DXD motif; other site 477641003038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 477641003039 EamA-like transporter family; Region: EamA; pfam00892 477641003040 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641003041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003042 NAD(P) binding site [chemical binding]; other site 477641003043 active site 477641003044 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 477641003045 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 477641003046 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 477641003047 interface (dimer of trimers) [polypeptide binding]; other site 477641003048 Substrate-binding/catalytic site; other site 477641003049 Zn-binding sites [ion binding]; other site 477641003050 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 477641003051 Predicted ATPase [General function prediction only]; Region: COG3903 477641003052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641003053 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 477641003054 Walker A/P-loop; other site 477641003055 ATP binding site [chemical binding]; other site 477641003056 Q-loop/lid; other site 477641003057 ABC transporter signature motif; other site 477641003058 Walker B; other site 477641003059 D-loop; other site 477641003060 H-loop/switch region; other site 477641003061 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 477641003062 phytoene desaturase; Region: crtI_fam; TIGR02734 477641003063 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 477641003064 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641003065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641003066 Walker A/P-loop; other site 477641003067 ATP binding site [chemical binding]; other site 477641003068 Q-loop/lid; other site 477641003069 ABC transporter signature motif; other site 477641003070 Walker B; other site 477641003071 D-loop; other site 477641003072 H-loop/switch region; other site 477641003073 Uncharacterized conserved protein [Function unknown]; Region: COG4850 477641003074 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 477641003075 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 477641003076 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641003077 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 477641003078 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 477641003079 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 477641003080 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641003081 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641003082 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 477641003083 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 477641003084 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 477641003085 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 477641003086 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641003087 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 477641003088 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 477641003089 ligand binding site; other site 477641003090 oligomer interface; other site 477641003091 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 477641003092 dimer interface [polypeptide binding]; other site 477641003093 N-terminal domain interface [polypeptide binding]; other site 477641003094 sulfate 1 binding site; other site 477641003095 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 477641003096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641003097 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 477641003098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641003099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641003100 DNA binding residues [nucleotide binding] 477641003101 Putative zinc-finger; Region: zf-HC2; pfam13490 477641003102 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 477641003103 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 477641003104 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 477641003105 protein binding site [polypeptide binding]; other site 477641003106 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 477641003107 Domain of unknown function DUF59; Region: DUF59; pfam01883 477641003108 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 477641003109 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 477641003110 AzlC protein; Region: AzlC; pfam03591 477641003111 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 477641003112 PRC-barrel domain; Region: PRC; pfam05239 477641003113 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 477641003114 MgtE intracellular N domain; Region: MgtE_N; smart00924 477641003115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 477641003116 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 477641003117 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 477641003118 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 477641003119 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 477641003120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641003121 active site 477641003122 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641003123 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 477641003124 putative NAD(P) binding site [chemical binding]; other site 477641003125 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 477641003126 A new structural DNA glycosylase; Region: AlkD_like; cl11434 477641003127 active site 477641003128 hypothetical protein; Validated; Region: PRK07586 477641003129 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 477641003130 PYR/PP interface [polypeptide binding]; other site 477641003131 dimer interface [polypeptide binding]; other site 477641003132 TPP binding site [chemical binding]; other site 477641003133 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 477641003134 TPP-binding site [chemical binding]; other site 477641003135 dimer interface [polypeptide binding]; other site 477641003136 PGAP1-like protein; Region: PGAP1; pfam07819 477641003137 Clp amino terminal domain; Region: Clp_N; pfam02861 477641003138 Clp amino terminal domain; Region: Clp_N; pfam02861 477641003139 Uncharacterized conserved protein [Function unknown]; Region: COG2128 477641003140 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 477641003141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641003142 active site 477641003143 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 477641003144 Cellulose synthase-like protein; Region: PLN02893 477641003145 short chain dehydrogenase; Provisional; Region: PRK06523 477641003146 classical (c) SDRs; Region: SDR_c; cd05233 477641003147 NAD(P) binding site [chemical binding]; other site 477641003148 active site 477641003149 PGAP1-like protein; Region: PGAP1; pfam07819 477641003150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641003151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641003152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003153 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 477641003154 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 477641003155 ATP binding site [chemical binding]; other site 477641003156 Walker A motif; other site 477641003157 hexamer interface [polypeptide binding]; other site 477641003158 Walker B motif; other site 477641003159 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 477641003160 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 477641003161 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 477641003162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641003163 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 477641003164 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 477641003165 active site 477641003166 FMN binding site [chemical binding]; other site 477641003167 substrate binding site [chemical binding]; other site 477641003168 3Fe-4S cluster binding site [ion binding]; other site 477641003169 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 477641003170 active site 477641003171 catalytic residues [active] 477641003172 PAS fold; Region: PAS; pfam00989 477641003173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641003174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641003175 metal binding site [ion binding]; metal-binding site 477641003176 active site 477641003177 I-site; other site 477641003178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641003179 peptide chain release factor 2; Validated; Region: prfB; PRK00578 477641003180 This domain is found in peptide chain release factors; Region: PCRF; smart00937 477641003181 RF-1 domain; Region: RF-1; pfam00472 477641003182 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 477641003183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641003184 Walker A/P-loop; other site 477641003185 ATP binding site [chemical binding]; other site 477641003186 Q-loop/lid; other site 477641003187 ABC transporter signature motif; other site 477641003188 Walker B; other site 477641003189 D-loop; other site 477641003190 H-loop/switch region; other site 477641003191 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 477641003192 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 477641003193 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 477641003194 SmpB-tmRNA interface; other site 477641003195 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641003196 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 477641003197 putative NAD(P) binding site [chemical binding]; other site 477641003198 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641003199 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641003200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 477641003201 active site 477641003202 GYD domain; Region: GYD; cl01743 477641003203 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 477641003204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641003205 Coenzyme A binding pocket [chemical binding]; other site 477641003206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641003207 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 477641003208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003209 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641003210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003211 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 477641003212 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 477641003213 transmembrane helices; other site 477641003214 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 477641003215 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 477641003216 oligomer interface [polypeptide binding]; other site 477641003217 metal binding site [ion binding]; metal-binding site 477641003218 metal binding site [ion binding]; metal-binding site 477641003219 putative Cl binding site [ion binding]; other site 477641003220 basic sphincter; other site 477641003221 hydrophobic gate; other site 477641003222 periplasmic entrance; other site 477641003223 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 477641003224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 477641003225 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 477641003226 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 477641003227 methionine synthase; Provisional; Region: PRK01207 477641003228 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 477641003229 substrate binding site [chemical binding]; other site 477641003230 THF binding site; other site 477641003231 zinc-binding site [ion binding]; other site 477641003232 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 477641003233 MMPL family; Region: MMPL; pfam03176 477641003234 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 477641003235 amino acid transporter; Region: 2A0306; TIGR00909 477641003236 Ion channel; Region: Ion_trans_2; pfam07885 477641003237 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 477641003238 TrkA-N domain; Region: TrkA_N; pfam02254 477641003239 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 477641003240 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641003241 subunit interaction site [polypeptide binding]; other site 477641003242 PHB binding site; other site 477641003243 CoenzymeA binding site [chemical binding]; other site 477641003244 MarR family; Region: MarR_2; pfam12802 477641003245 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641003246 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641003247 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 477641003248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641003249 acyl-activating enzyme (AAE) consensus motif; other site 477641003250 AMP binding site [chemical binding]; other site 477641003251 active site 477641003252 CoA binding site [chemical binding]; other site 477641003253 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 477641003254 active site 477641003255 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 477641003256 enoyl-CoA hydratase; Provisional; Region: PRK08252 477641003257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641003258 substrate binding site [chemical binding]; other site 477641003259 oxyanion hole (OAH) forming residues; other site 477641003260 trimer interface [polypeptide binding]; other site 477641003261 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641003262 putative active site [active] 477641003263 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 477641003264 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 477641003265 putative active site [active] 477641003266 catalytic site [active] 477641003267 putative metal binding site [ion binding]; other site 477641003268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641003269 MarR family; Region: MarR_2; pfam12802 477641003270 Uncharacterized conserved protein [Function unknown]; Region: COG2353 477641003271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641003272 putative active site [active] 477641003273 heme pocket [chemical binding]; other site 477641003274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641003275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641003276 metal binding site [ion binding]; metal-binding site 477641003277 active site 477641003278 I-site; other site 477641003279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641003280 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 477641003281 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 477641003282 catalytic residues [active] 477641003283 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 477641003284 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 477641003285 G1 box; other site 477641003286 putative GEF interaction site [polypeptide binding]; other site 477641003287 GTP/Mg2+ binding site [chemical binding]; other site 477641003288 Switch I region; other site 477641003289 G2 box; other site 477641003290 G3 box; other site 477641003291 Switch II region; other site 477641003292 G4 box; other site 477641003293 G5 box; other site 477641003294 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 477641003295 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 477641003296 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641003297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003298 NAD(P) binding site [chemical binding]; other site 477641003299 active site 477641003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641003301 S-adenosylmethionine binding site [chemical binding]; other site 477641003302 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 477641003303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641003304 sequence-specific DNA binding site [nucleotide binding]; other site 477641003305 salt bridge; other site 477641003306 Cupin domain; Region: Cupin_2; pfam07883 477641003307 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641003308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003309 putative substrate translocation pore; other site 477641003310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003311 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 477641003312 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 477641003313 CopC domain; Region: CopC; pfam04234 477641003314 FixH; Region: FixH; pfam05751 477641003315 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 477641003316 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 477641003317 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 477641003318 Cu(I) binding site [ion binding]; other site 477641003319 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641003320 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641003321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641003323 active site 477641003324 phosphorylation site [posttranslational modification] 477641003325 intermolecular recognition site; other site 477641003326 dimerization interface [polypeptide binding]; other site 477641003327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641003328 DNA binding site [nucleotide binding] 477641003329 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 477641003330 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 477641003331 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 477641003332 Ligand Binding Site [chemical binding]; other site 477641003333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641003334 dimer interface [polypeptide binding]; other site 477641003335 phosphorylation site [posttranslational modification] 477641003336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641003337 ATP binding site [chemical binding]; other site 477641003338 Mg2+ binding site [ion binding]; other site 477641003339 G-X-G motif; other site 477641003340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641003341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641003342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641003343 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 477641003344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641003345 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 477641003346 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 477641003347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641003348 Soluble P-type ATPase [General function prediction only]; Region: COG4087 477641003349 K+-transporting ATPase, c chain; Region: KdpC; cl00944 477641003350 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641003351 GAF domain; Region: GAF; pfam01590 477641003352 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641003353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003354 short chain dehydrogenase; Provisional; Region: PRK12828 477641003355 NAD(P) binding site [chemical binding]; other site 477641003356 active site 477641003357 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641003358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641003359 salt bridge; other site 477641003360 non-specific DNA binding site [nucleotide binding]; other site 477641003361 sequence-specific DNA binding site [nucleotide binding]; other site 477641003362 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641003363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641003364 salt bridge; other site 477641003365 non-specific DNA binding site [nucleotide binding]; other site 477641003366 sequence-specific DNA binding site [nucleotide binding]; other site 477641003367 short chain dehydrogenase; Provisional; Region: PRK06482 477641003368 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 477641003369 NADP binding site [chemical binding]; other site 477641003370 active site 477641003371 steroid binding site; other site 477641003372 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 477641003373 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641003374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641003375 active site 477641003376 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641003377 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 477641003378 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 477641003379 classical (c) SDRs; Region: SDR_c; cd05233 477641003380 NAD(P) binding site [chemical binding]; other site 477641003381 active site 477641003382 CAAX protease self-immunity; Region: Abi; pfam02517 477641003383 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 477641003384 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 477641003385 Ligand binding site; other site 477641003386 Putative Catalytic site; other site 477641003387 DXD motif; other site 477641003388 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 477641003389 intracellular protease, PfpI family; Region: PfpI; TIGR01382 477641003390 proposed catalytic triad [active] 477641003391 conserved cys residue [active] 477641003392 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641003393 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 477641003394 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 477641003395 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 477641003396 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 477641003397 Moco binding site; other site 477641003398 metal coordination site [ion binding]; other site 477641003399 murein hydrolase B; Provisional; Region: PRK10760; cl17906 477641003400 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 477641003401 N-acetyl-D-glucosamine binding site [chemical binding]; other site 477641003402 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 477641003403 Domain of unknown function DUF11; Region: DUF11; cl17728 477641003404 Domain of unknown function DUF11; Region: DUF11; pfam01345 477641003405 Integrin alpha; Region: Integrin_alpha2; pfam08441 477641003406 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 477641003407 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 477641003408 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 477641003409 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 477641003410 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 477641003411 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 477641003412 ATP binding site [chemical binding]; other site 477641003413 Walker A motif; other site 477641003414 hexamer interface [polypeptide binding]; other site 477641003415 Walker B motif; other site 477641003416 septum site-determining protein MinD; Region: minD_bact; TIGR01968 477641003417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641003418 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 477641003419 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 477641003420 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641003421 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641003422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641003423 ATP binding site [chemical binding]; other site 477641003424 Mg2+ binding site [ion binding]; other site 477641003425 G-X-G motif; other site 477641003426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641003427 PAS fold; Region: PAS_3; pfam08447 477641003428 putative active site [active] 477641003429 heme pocket [chemical binding]; other site 477641003430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641003431 PAS domain; Region: PAS_9; pfam13426 477641003432 putative active site [active] 477641003433 heme pocket [chemical binding]; other site 477641003434 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641003435 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 477641003436 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 477641003437 active site 477641003438 FMN binding site [chemical binding]; other site 477641003439 substrate binding site [chemical binding]; other site 477641003440 homotetramer interface [polypeptide binding]; other site 477641003441 catalytic residue [active] 477641003442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003443 putative substrate translocation pore; other site 477641003444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003445 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 477641003446 classical (c) SDRs; Region: SDR_c; cd05233 477641003447 NAD(P) binding site [chemical binding]; other site 477641003448 active site 477641003449 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641003450 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 477641003451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641003453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003454 WHG domain; Region: WHG; pfam13305 477641003455 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 477641003456 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 477641003457 tetramer interface [polypeptide binding]; other site 477641003458 active site 477641003459 Mg2+/Mn2+ binding site [ion binding]; other site 477641003460 Methyltransferase domain; Region: Methyltransf_12; pfam08242 477641003461 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 477641003462 acyl-coenzyme A oxidase; Region: PLN02526 477641003463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641003464 active site 477641003465 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 477641003466 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 477641003467 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 477641003468 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 477641003469 FAD binding pocket [chemical binding]; other site 477641003470 FAD binding motif [chemical binding]; other site 477641003471 phosphate binding motif [ion binding]; other site 477641003472 NAD binding pocket [chemical binding]; other site 477641003473 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 477641003474 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 477641003475 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 477641003476 Domain of unknown function (DUF385); Region: DUF385; pfam04075 477641003477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003478 NAD(P) binding site [chemical binding]; other site 477641003479 active site 477641003480 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641003481 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641003482 active site 477641003483 catalytic tetrad [active] 477641003484 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 477641003485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641003486 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 477641003487 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 477641003488 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 477641003489 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 477641003490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641003491 Walker A/P-loop; other site 477641003492 ATP binding site [chemical binding]; other site 477641003493 Q-loop/lid; other site 477641003494 ABC transporter signature motif; other site 477641003495 Walker B; other site 477641003496 D-loop; other site 477641003497 H-loop/switch region; other site 477641003498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641003499 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 477641003500 4Fe-4S binding domain; Region: Fer4_6; pfam12837 477641003501 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 477641003502 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641003503 active site 477641003504 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 477641003505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 477641003506 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 477641003507 FAD binding domain; Region: FAD_binding_4; pfam01565 477641003508 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 477641003509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641003511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641003512 active site 477641003513 catalytic tetrad [active] 477641003514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003515 putative substrate translocation pore; other site 477641003516 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641003517 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641003518 NAD binding site [chemical binding]; other site 477641003519 catalytic Zn binding site [ion binding]; other site 477641003520 structural Zn binding site [ion binding]; other site 477641003521 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641003522 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641003523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641003525 putative substrate translocation pore; other site 477641003526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641003527 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 477641003528 homotetramer interface [polypeptide binding]; other site 477641003529 active site 477641003530 metal binding site [ion binding]; metal-binding site 477641003531 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 477641003532 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 477641003533 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 477641003534 D-pathway; other site 477641003535 Putative ubiquinol binding site [chemical binding]; other site 477641003536 Low-spin heme (heme b) binding site [chemical binding]; other site 477641003537 Putative water exit pathway; other site 477641003538 Binuclear center (heme o3/CuB) [ion binding]; other site 477641003539 K-pathway; other site 477641003540 Putative proton exit pathway; other site 477641003541 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641003542 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641003543 phosphoserine phosphatase SerB; Region: serB; TIGR00338 477641003544 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 477641003545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641003546 motif II; other site 477641003547 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 477641003548 Isochorismatase family; Region: Isochorismatase; pfam00857 477641003549 catalytic triad [active] 477641003550 metal binding site [ion binding]; metal-binding site 477641003551 conserved cis-peptide bond; other site 477641003552 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 477641003553 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 477641003554 active site 477641003555 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 477641003556 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 477641003557 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 477641003558 MPN+ (JAMM) motif; other site 477641003559 Zinc-binding site [ion binding]; other site 477641003560 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 477641003561 MoaE interaction surface [polypeptide binding]; other site 477641003562 MoeB interaction surface [polypeptide binding]; other site 477641003563 thiocarboxylated glycine; other site 477641003564 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 477641003565 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 477641003566 dimer interface [polypeptide binding]; other site 477641003567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641003568 catalytic residue [active] 477641003569 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 477641003570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641003571 active site 477641003572 motif I; other site 477641003573 motif II; other site 477641003574 glutamate racemase; Provisional; Region: PRK00865 477641003575 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 477641003576 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 477641003577 nucleotide binding site [chemical binding]; other site 477641003578 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 477641003579 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 477641003580 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 477641003581 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 477641003582 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 477641003583 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 477641003584 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 477641003585 catalytic triad [active] 477641003586 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 477641003587 ribonuclease PH; Reviewed; Region: rph; PRK00173 477641003588 Ribonuclease PH; Region: RNase_PH_bact; cd11362 477641003589 hexamer interface [polypeptide binding]; other site 477641003590 active site 477641003591 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 477641003592 active site 477641003593 dimerization interface [polypeptide binding]; other site 477641003594 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641003595 Methyltransferase domain; Region: Methyltransf_11; pfam08241 477641003596 S-adenosylmethionine binding site [chemical binding]; other site 477641003597 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 477641003598 Domain of unknown function (DUF427); Region: DUF427; pfam04248 477641003599 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 477641003600 putative homotetramer interface [polypeptide binding]; other site 477641003601 putative homodimer interface [polypeptide binding]; other site 477641003602 putative allosteric switch controlling residues; other site 477641003603 putative metal binding site [ion binding]; other site 477641003604 putative homodimer-homodimer interface [polypeptide binding]; other site 477641003605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 477641003606 metal-binding site [ion binding] 477641003607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 477641003608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 477641003609 metal-binding site [ion binding] 477641003610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641003611 Soluble P-type ATPase [General function prediction only]; Region: COG4087 477641003612 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641003613 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641003614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641003615 catalytic core [active] 477641003616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641003617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641003618 active site 477641003619 catalytic tetrad [active] 477641003620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641003621 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 477641003622 active site 477641003623 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641003624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003625 NAD(P) binding site [chemical binding]; other site 477641003626 active site 477641003627 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 477641003628 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641003629 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 477641003630 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 477641003631 active site 477641003632 metal binding site [ion binding]; metal-binding site 477641003633 nudix motif; other site 477641003634 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641003635 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641003636 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641003637 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 477641003638 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 477641003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641003640 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 477641003641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641003642 PAS fold; Region: PAS_2; pfam08446 477641003643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641003644 GAF domain; Region: GAF; pfam01590 477641003645 Phytochrome region; Region: PHY; pfam00360 477641003646 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641003647 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 477641003648 heme binding pocket [chemical binding]; other site 477641003649 heme ligand [chemical binding]; other site 477641003650 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641003651 Proline dehydrogenase; Region: Pro_dh; cl03282 477641003652 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 477641003653 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 477641003654 Glutamate binding site [chemical binding]; other site 477641003655 NAD binding site [chemical binding]; other site 477641003656 catalytic residues [active] 477641003657 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 477641003658 AAA domain; Region: AAA_33; pfam13671 477641003659 ATP-binding site [chemical binding]; other site 477641003660 Gluconate-6-phosphate binding site [chemical binding]; other site 477641003661 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 477641003662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641003663 substrate binding site [chemical binding]; other site 477641003664 oxyanion hole (OAH) forming residues; other site 477641003665 trimer interface [polypeptide binding]; other site 477641003666 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641003667 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641003668 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641003669 GAF domain; Region: GAF; pfam01590 477641003670 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641003671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641003672 MarR family; Region: MarR_2; cl17246 477641003673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641003674 classical (c) SDRs; Region: SDR_c; cd05233 477641003675 NAD(P) binding site [chemical binding]; other site 477641003676 active site 477641003677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 477641003678 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 477641003679 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 477641003680 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 477641003681 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 477641003682 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 477641003683 catalytic site [active] 477641003684 putative active site [active] 477641003685 putative substrate binding site [chemical binding]; other site 477641003686 dimer interface [polypeptide binding]; other site 477641003687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641003688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003689 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 477641003690 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 477641003691 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 477641003692 Ferritin-like domain; Region: Ferritin; pfam00210 477641003693 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 477641003694 ferroxidase diiron center [ion binding]; other site 477641003695 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 477641003696 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641003697 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641003698 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 477641003699 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641003700 carboxyltransferase (CT) interaction site; other site 477641003701 biotinylation site [posttranslational modification]; other site 477641003702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641003703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641003704 active site 477641003705 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 477641003706 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 477641003707 active site 477641003708 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641003709 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 477641003710 NAD(P) binding site [chemical binding]; other site 477641003711 Transcription factor WhiB; Region: Whib; pfam02467 477641003712 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 477641003713 Cupin domain; Region: Cupin_2; cl17218 477641003714 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641003715 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641003716 TM-ABC transporter signature motif; other site 477641003717 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641003718 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641003719 Walker A/P-loop; other site 477641003720 ATP binding site [chemical binding]; other site 477641003721 Q-loop/lid; other site 477641003722 ABC transporter signature motif; other site 477641003723 Walker B; other site 477641003724 D-loop; other site 477641003725 H-loop/switch region; other site 477641003726 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641003727 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 477641003728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 477641003729 putative ligand binding site [chemical binding]; other site 477641003730 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 477641003731 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 477641003732 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 477641003733 putative hydrophobic ligand binding site [chemical binding]; other site 477641003734 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 477641003735 active site 477641003736 catalytic site [active] 477641003737 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 477641003738 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 477641003739 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 477641003740 FO synthase; Reviewed; Region: fbiC; PRK09234 477641003741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641003742 FeS/SAM binding site; other site 477641003743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641003744 FeS/SAM binding site; other site 477641003745 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 477641003746 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 477641003747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641003748 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641003749 ATP-NAD kinase; Region: NAD_kinase; pfam01513 477641003750 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 477641003751 YCII-related domain; Region: YCII; cl00999 477641003752 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 477641003753 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 477641003754 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 477641003755 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 477641003756 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 477641003757 active site 477641003758 catalytic triad [active] 477641003759 oxyanion hole [active] 477641003760 PAS domain; Region: PAS_9; pfam13426 477641003761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641003762 putative active site [active] 477641003763 heme pocket [chemical binding]; other site 477641003764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641003765 metal binding site [ion binding]; metal-binding site 477641003766 active site 477641003767 I-site; other site 477641003768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641003769 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641003770 anti sigma factor interaction site; other site 477641003771 regulatory phosphorylation site [posttranslational modification]; other site 477641003772 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641003773 anti sigma factor interaction site; other site 477641003774 regulatory phosphorylation site [posttranslational modification]; other site 477641003775 Domain of unknown function (DUF427); Region: DUF427; pfam04248 477641003776 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 477641003777 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641003778 MULE transposase domain; Region: MULE; pfam10551 477641003779 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 477641003780 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 477641003781 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 477641003782 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641003783 FAD binding domain; Region: FAD_binding_4; pfam01565 477641003784 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 477641003785 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 477641003786 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 477641003787 FMN-binding pocket [chemical binding]; other site 477641003788 flavin binding motif; other site 477641003789 phosphate binding motif [ion binding]; other site 477641003790 beta-alpha-beta structure motif; other site 477641003791 NAD binding pocket [chemical binding]; other site 477641003792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641003793 catalytic loop [active] 477641003794 iron binding site [ion binding]; other site 477641003795 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 477641003796 FAD binding site [chemical binding]; other site 477641003797 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 477641003798 active site 477641003799 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 477641003800 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 477641003801 Walker A/P-loop; other site 477641003802 ATP binding site [chemical binding]; other site 477641003803 Q-loop/lid; other site 477641003804 ABC transporter signature motif; other site 477641003805 Walker B; other site 477641003806 D-loop; other site 477641003807 H-loop/switch region; other site 477641003808 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 477641003809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641003810 dimer interface [polypeptide binding]; other site 477641003811 conserved gate region; other site 477641003812 putative PBP binding loops; other site 477641003813 ABC-ATPase subunit interface; other site 477641003814 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 477641003815 active site 477641003816 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 477641003817 non-prolyl cis peptide bond; other site 477641003818 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 477641003819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641003820 active site 477641003821 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 477641003822 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 477641003823 [2Fe-2S] cluster binding site [ion binding]; other site 477641003824 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 477641003825 hydrophobic ligand binding site; other site 477641003826 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641003827 FAD binding domain; Region: FAD_binding_4; pfam01565 477641003828 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 477641003829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641003830 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641003831 amidase; Provisional; Region: PRK06170 477641003832 Amidase; Region: Amidase; cl11426 477641003833 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 477641003834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641003835 active site 477641003836 Creatinine amidohydrolase; Region: Creatininase; pfam02633 477641003837 classical (c) SDRs; Region: SDR_c; cd05233 477641003838 NAD(P) binding site [chemical binding]; other site 477641003839 active site 477641003840 Isochorismatase family; Region: Isochorismatase; pfam00857 477641003841 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 477641003842 catalytic triad [active] 477641003843 conserved cis-peptide bond; other site 477641003844 Cupin domain; Region: Cupin_2; cl17218 477641003845 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 477641003846 Amidase; Region: Amidase; cl11426 477641003847 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641003848 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641003849 FAD binding domain; Region: FAD_binding_4; pfam01565 477641003850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641003851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 477641003852 active site 477641003853 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 477641003854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 477641003855 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 477641003856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641003857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641003858 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641003859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 477641003860 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641003861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 477641003862 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641003863 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641003864 Transcription factor WhiB; Region: Whib; pfam02467 477641003865 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 477641003866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641003867 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641003868 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641003869 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641003870 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641003871 Domain of unknown function (DUF389); Region: DUF389; pfam04087 477641003872 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 477641003873 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641003874 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641003875 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641003876 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641003877 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 477641003878 Domain of unknown function DUF20; Region: UPF0118; pfam01594 477641003879 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641003880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641003881 DNA binding residues [nucleotide binding] 477641003882 dimerization interface [polypeptide binding]; other site 477641003883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641003884 active site 477641003885 Int/Topo IB signature motif; other site 477641003886 DNA binding site [nucleotide binding] 477641003887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641003888 DNA binding site [nucleotide binding] 477641003889 active site 477641003890 Int/Topo IB signature motif; other site 477641003891 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 477641003892 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 477641003893 dimer interface [polypeptide binding]; other site 477641003894 ssDNA binding site [nucleotide binding]; other site 477641003895 tetramer (dimer of dimers) interface [polypeptide binding]; other site 477641003896 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 477641003897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641003898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641003899 ABC transporter; Region: ABC_tran_2; pfam12848 477641003900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641003901 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 477641003902 active site 477641003903 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 477641003904 active site 477641003905 MOSC domain; Region: MOSC; pfam03473 477641003906 Cobalt transport protein; Region: CbiQ; cl00463 477641003907 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 477641003908 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 477641003909 Walker A/P-loop; other site 477641003910 ATP binding site [chemical binding]; other site 477641003911 Q-loop/lid; other site 477641003912 ABC transporter signature motif; other site 477641003913 Walker B; other site 477641003914 D-loop; other site 477641003915 H-loop/switch region; other site 477641003916 BioY family; Region: BioY; pfam02632 477641003917 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 477641003918 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641003919 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641003920 Walker A/P-loop; other site 477641003921 ATP binding site [chemical binding]; other site 477641003922 Q-loop/lid; other site 477641003923 ABC transporter signature motif; other site 477641003924 Walker B; other site 477641003925 D-loop; other site 477641003926 H-loop/switch region; other site 477641003927 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641003928 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 477641003929 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 477641003930 active site 477641003931 catalytic site [active] 477641003932 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 477641003933 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 477641003934 apolar tunnel; other site 477641003935 heme binding site [chemical binding]; other site 477641003936 dimerization interface [polypeptide binding]; other site 477641003937 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641003938 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 477641003939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641003940 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 477641003941 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641003942 active site 477641003943 kynureninase; Region: kynureninase; TIGR01814 477641003944 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641003945 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641003946 catalytic residue [active] 477641003947 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641003948 Amidase; Region: Amidase; pfam01425 477641003949 Repair protein; Region: Repair_PSII; pfam04536 477641003950 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 477641003951 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 477641003952 Zn binding site [ion binding]; other site 477641003953 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 477641003954 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 477641003955 short chain dehydrogenase; Provisional; Region: PRK08251 477641003956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003957 NAD(P) binding site [chemical binding]; other site 477641003958 active site 477641003959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641003960 Protein of unknown function (DUF429); Region: DUF429; cl12046 477641003961 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 477641003962 hypothetical protein; Provisional; Region: PRK01346 477641003963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 477641003964 MMPL family; Region: MMPL; pfam03176 477641003965 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641003966 potential frameshift: common BLAST hit: gi|386845535|ref|YP_006263548.1| Response regulator gacA 477641003967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641003968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641003969 DNA binding residues [nucleotide binding] 477641003970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641003971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 477641003972 active site 477641003973 phosphorylation site [posttranslational modification] 477641003974 intermolecular recognition site; other site 477641003975 dimerization interface [polypeptide binding]; other site 477641003976 Putative sensor; Region: Sensor; pfam13796 477641003977 Histidine kinase; Region: HisKA_3; pfam07730 477641003978 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641003979 ATP binding site [chemical binding]; other site 477641003980 Mg2+ binding site [ion binding]; other site 477641003981 G-X-G motif; other site 477641003982 RNA polymerase factor sigma-70; Validated; Region: PRK08241 477641003983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641003984 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 477641003985 DNA binding residues [nucleotide binding] 477641003986 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641003987 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641003988 active site 477641003989 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641003990 RibD C-terminal domain; Region: RibD_C; cl17279 477641003991 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641003992 short chain dehydrogenase; Validated; Region: PRK06182 477641003993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641003994 NAD(P) binding site [chemical binding]; other site 477641003995 active site 477641003996 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641003997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641003998 DNA binding residues [nucleotide binding] 477641003999 dimerization interface [polypeptide binding]; other site 477641004000 Cupin domain; Region: Cupin_2; pfam07883 477641004001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641004002 Coenzyme A binding pocket [chemical binding]; other site 477641004003 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 477641004004 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 477641004005 PemK-like protein; Region: PemK; pfam02452 477641004006 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004007 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004008 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641004009 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641004010 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004011 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004012 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641004013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641004014 S-adenosylmethionine binding site [chemical binding]; other site 477641004015 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 477641004016 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 477641004017 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 477641004018 putative active site [active] 477641004019 catalytic triad [active] 477641004020 putative dimer interface [polypeptide binding]; other site 477641004021 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641004022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641004023 catalytic residues [active] 477641004024 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 477641004025 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641004026 active site residue [active] 477641004027 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 477641004028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004030 active site 477641004031 phosphorylation site [posttranslational modification] 477641004032 intermolecular recognition site; other site 477641004033 dimerization interface [polypeptide binding]; other site 477641004034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641004035 DNA binding site [nucleotide binding] 477641004036 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 477641004037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641004038 dimerization interface [polypeptide binding]; other site 477641004039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641004040 dimer interface [polypeptide binding]; other site 477641004041 phosphorylation site [posttranslational modification] 477641004042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641004043 Mg2+ binding site [ion binding]; other site 477641004044 G-X-G motif; other site 477641004045 Methyltransferase domain; Region: Methyltransf_11; pfam08241 477641004046 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 477641004047 Copper resistance protein D; Region: CopD; pfam05425 477641004048 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641004049 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641004050 catalytic residues [active] 477641004051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 477641004052 binding surface 477641004053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 477641004054 TPR motif; other site 477641004055 Tetratricopeptide repeat; Region: TPR_16; pfam13432 477641004056 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 477641004057 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 477641004058 CcmE; Region: CcmE; cl00994 477641004059 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 477641004060 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641004061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641004062 Walker A/P-loop; other site 477641004063 ATP binding site [chemical binding]; other site 477641004064 Q-loop/lid; other site 477641004065 ABC transporter signature motif; other site 477641004066 Walker B; other site 477641004067 D-loop; other site 477641004068 H-loop/switch region; other site 477641004069 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 477641004070 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 477641004071 Peptidase family M48; Region: Peptidase_M48; cl12018 477641004072 Penicillinase repressor; Region: Pencillinase_R; pfam03965 477641004073 Domain of unknown function (DUF305); Region: DUF305; pfam03713 477641004074 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 477641004075 dimerization interface [polypeptide binding]; other site 477641004076 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 477641004077 putative homotetramer interface [polypeptide binding]; other site 477641004078 putative homodimer interface [polypeptide binding]; other site 477641004079 putative allosteric switch controlling residues; other site 477641004080 putative metal binding site [ion binding]; other site 477641004081 putative homodimer-homodimer interface [polypeptide binding]; other site 477641004082 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 477641004083 metal-binding site [ion binding] 477641004084 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 477641004085 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 477641004086 metal-binding site [ion binding] 477641004087 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641004088 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 477641004089 NADH dehydrogenase; Region: NADHdh; cl00469 477641004090 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641004091 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641004092 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 477641004093 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641004094 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004095 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004096 Transposase; Region: HTH_Tnp_1; cl17663 477641004097 HTH-like domain; Region: HTH_21; pfam13276 477641004098 Integrase core domain; Region: rve; pfam00665 477641004099 Integrase core domain; Region: rve_3; pfam13683 477641004100 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 477641004101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641004102 Soluble P-type ATPase [General function prediction only]; Region: COG4087 477641004103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004104 dimerization interface [polypeptide binding]; other site 477641004105 putative DNA binding site [nucleotide binding]; other site 477641004106 putative Zn2+ binding site [ion binding]; other site 477641004107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 477641004108 putative Zn2+ binding site [ion binding]; other site 477641004109 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 477641004110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004111 putative DNA binding site [nucleotide binding]; other site 477641004112 putative Zn2+ binding site [ion binding]; other site 477641004113 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 477641004114 putative active site [active] 477641004115 catalytic triad [active] 477641004116 putative dimer interface [polypeptide binding]; other site 477641004117 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641004118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641004119 catalytic residues [active] 477641004120 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 477641004121 ResB-like family; Region: ResB; pfam05140 477641004122 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 477641004123 Domain of unknown function (DUF305); Region: DUF305; pfam03713 477641004124 Response regulator receiver domain; Region: Response_reg; pfam00072 477641004125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004126 active site 477641004127 phosphorylation site [posttranslational modification] 477641004128 intermolecular recognition site; other site 477641004129 dimerization interface [polypeptide binding]; other site 477641004130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004131 putative Zn2+ binding site [ion binding]; other site 477641004132 putative DNA binding site [nucleotide binding]; other site 477641004133 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 477641004134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641004135 Soluble P-type ATPase [General function prediction only]; Region: COG4087 477641004136 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 477641004137 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 477641004138 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 477641004139 homodimer interface [polypeptide binding]; other site 477641004140 NAD binding pocket [chemical binding]; other site 477641004141 ATP binding pocket [chemical binding]; other site 477641004142 Mg binding site [ion binding]; other site 477641004143 active-site loop [active] 477641004144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641004145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004146 dimerization interface [polypeptide binding]; other site 477641004147 putative DNA binding site [nucleotide binding]; other site 477641004148 putative Zn2+ binding site [ion binding]; other site 477641004149 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 477641004150 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 477641004151 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641004152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641004153 S-adenosylmethionine binding site [chemical binding]; other site 477641004154 Cadmium resistance transporter; Region: Cad; pfam03596 477641004155 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 477641004156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641004157 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641004158 Iron permease FTR1 family; Region: FTR1; pfam03239 477641004159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641004160 Walker A/P-loop; other site 477641004161 ATP binding site [chemical binding]; other site 477641004162 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 477641004163 dimerization interface [polypeptide binding]; other site 477641004164 putative Zn2+ binding site [ion binding]; other site 477641004165 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 477641004166 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641004167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641004168 active site 477641004169 Int/Topo IB signature motif; other site 477641004170 DNA binding site [nucleotide binding] 477641004171 Helix-turn-helix domain; Region: HTH_17; cl17695 477641004172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641004173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641004174 non-specific DNA binding site [nucleotide binding]; other site 477641004175 salt bridge; other site 477641004176 sequence-specific DNA binding site [nucleotide binding]; other site 477641004177 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 477641004178 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 477641004179 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641004180 Walker A motif; other site 477641004181 ATP binding site [chemical binding]; other site 477641004182 Walker B motif; other site 477641004183 TadE-like protein; Region: TadE; pfam07811 477641004184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641004185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641004186 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 477641004187 AAA domain; Region: AAA_31; pfam13614 477641004188 AAA-like domain; Region: AAA_10; pfam12846 477641004189 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004190 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004191 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 477641004192 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 477641004193 GAF domain; Region: GAF; pfam01590 477641004194 GAF domain; Region: GAF_2; pfam13185 477641004195 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641004196 TrwC relaxase; Region: TrwC; pfam08751 477641004197 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 477641004198 AAA domain; Region: AAA_30; pfam13604 477641004199 Family description; Region: UvrD_C_2; pfam13538 477641004200 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 477641004201 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 477641004202 active site 477641004203 metal binding site [ion binding]; metal-binding site 477641004204 interdomain interaction site; other site 477641004205 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 477641004206 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 477641004207 5' RNA guide strand anchoring site; other site 477641004208 active site 477641004209 TIR domain; Region: TIR_2; pfam13676 477641004210 Predicted helicase [General function prediction only]; Region: COG4889 477641004211 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 477641004212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641004213 ATP binding site [chemical binding]; other site 477641004214 putative Mg++ binding site [ion binding]; other site 477641004215 helicase superfamily c-terminal domain; Region: HELICc; smart00490 477641004216 nucleotide binding region [chemical binding]; other site 477641004217 ATP-binding site [chemical binding]; other site 477641004218 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 477641004219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641004220 catalytic residue [active] 477641004221 trigger factor; Provisional; Region: tig; PRK01490 477641004222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 477641004223 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 477641004224 Clp protease; Region: CLP_protease; pfam00574 477641004225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 477641004226 oligomer interface [polypeptide binding]; other site 477641004227 active site residues [active] 477641004228 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 477641004229 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 477641004230 oligomer interface [polypeptide binding]; other site 477641004231 active site residues [active] 477641004232 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 477641004233 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 477641004234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641004235 Walker A motif; other site 477641004236 ATP binding site [chemical binding]; other site 477641004237 Walker B motif; other site 477641004238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 477641004239 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641004240 putative active site [active] 477641004241 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 477641004242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641004243 active site 477641004244 HIGH motif; other site 477641004245 nucleotide binding site [chemical binding]; other site 477641004246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641004247 active site 477641004248 KMSKS motif; other site 477641004249 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 477641004250 tRNA binding surface [nucleotide binding]; other site 477641004251 anticodon binding site; other site 477641004252 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 477641004253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641004254 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 477641004255 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 477641004256 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 477641004257 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 477641004258 active site 477641004259 multimer interface [polypeptide binding]; other site 477641004260 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 477641004261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641004262 FeS/SAM binding site; other site 477641004263 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 477641004264 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 477641004265 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641004266 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641004267 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 477641004268 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 477641004269 GTPase CgtA; Reviewed; Region: obgE; PRK12296 477641004270 GTP1/OBG; Region: GTP1_OBG; pfam01018 477641004271 Obg GTPase; Region: Obg; cd01898 477641004272 G1 box; other site 477641004273 GTP/Mg2+ binding site [chemical binding]; other site 477641004274 Switch I region; other site 477641004275 G2 box; other site 477641004276 G3 box; other site 477641004277 Switch II region; other site 477641004278 G4 box; other site 477641004279 G5 box; other site 477641004280 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 477641004281 gamma-glutamyl kinase; Provisional; Region: PRK05429 477641004282 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 477641004283 nucleotide binding site [chemical binding]; other site 477641004284 homotetrameric interface [polypeptide binding]; other site 477641004285 putative phosphate binding site [ion binding]; other site 477641004286 putative allosteric binding site; other site 477641004287 PUA domain; Region: PUA; pfam01472 477641004288 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 477641004289 active site 477641004290 catalytic residues [active] 477641004291 metal binding site [ion binding]; metal-binding site 477641004292 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 477641004293 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 477641004294 putative catalytic cysteine [active] 477641004295 MoxR-like ATPases [General function prediction only]; Region: COG0714 477641004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641004297 Walker A motif; other site 477641004298 ATP binding site [chemical binding]; other site 477641004299 Walker B motif; other site 477641004300 arginine finger; other site 477641004301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 477641004302 metal ion-dependent adhesion site (MIDAS); other site 477641004303 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 477641004304 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 477641004305 active site 477641004306 (T/H)XGH motif; other site 477641004307 Oligomerisation domain; Region: Oligomerisation; cl00519 477641004308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641004309 catalytic core [active] 477641004310 EDD domain protein, DegV family; Region: DegV; TIGR00762 477641004311 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 477641004312 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 477641004313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641004314 Competence protein; Region: Competence; pfam03772 477641004315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641004316 hypothetical protein; Reviewed; Region: PRK07914 477641004317 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 477641004318 Serine hydrolase; Region: Ser_hydrolase; cl17834 477641004319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641004320 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 477641004321 GTP-binding protein LepA; Provisional; Region: PRK05433 477641004322 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 477641004323 G1 box; other site 477641004324 putative GEF interaction site [polypeptide binding]; other site 477641004325 GTP/Mg2+ binding site [chemical binding]; other site 477641004326 Switch I region; other site 477641004327 G2 box; other site 477641004328 G3 box; other site 477641004329 Switch II region; other site 477641004330 G4 box; other site 477641004331 G5 box; other site 477641004332 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 477641004333 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 477641004334 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 477641004335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 477641004336 MOSC domain; Region: MOSC; pfam03473 477641004337 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 477641004338 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641004339 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641004340 NAD(P) binding site [chemical binding]; other site 477641004341 selenium donor protein; Region: selD; TIGR00476 477641004342 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 477641004343 dimerization interface [polypeptide binding]; other site 477641004344 putative ATP binding site [chemical binding]; other site 477641004345 selenocysteine synthase; Provisional; Region: PRK04311 477641004346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641004347 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 477641004348 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 477641004349 G1 box; other site 477641004350 putative GEF interaction site [polypeptide binding]; other site 477641004351 GTP/Mg2+ binding site [chemical binding]; other site 477641004352 Switch I region; other site 477641004353 G2 box; other site 477641004354 G3 box; other site 477641004355 Switch II region; other site 477641004356 G4 box; other site 477641004357 G5 box; other site 477641004358 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 477641004359 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 477641004360 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 477641004361 enoyl-CoA hydratase; Provisional; Region: PRK07827 477641004362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641004363 substrate binding site [chemical binding]; other site 477641004364 oxyanion hole (OAH) forming residues; other site 477641004365 trimer interface [polypeptide binding]; other site 477641004366 coproporphyrinogen III oxidase; Validated; Region: PRK05628 477641004367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641004368 FeS/SAM binding site; other site 477641004369 HemN C-terminal domain; Region: HemN_C; pfam06969 477641004370 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 477641004371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641004372 ATP binding site [chemical binding]; other site 477641004373 putative Mg++ binding site [ion binding]; other site 477641004374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641004375 nucleotide binding region [chemical binding]; other site 477641004376 ATP-binding site [chemical binding]; other site 477641004377 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 477641004378 HRDC domain; Region: HRDC; pfam00570 477641004379 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641004380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641004381 Walker A/P-loop; other site 477641004382 ATP binding site [chemical binding]; other site 477641004383 Q-loop/lid; other site 477641004384 ABC transporter signature motif; other site 477641004385 Walker B; other site 477641004386 D-loop; other site 477641004387 H-loop/switch region; other site 477641004388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641004389 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641004390 ATP binding site [chemical binding]; other site 477641004391 Mg2+ binding site [ion binding]; other site 477641004392 G-X-G motif; other site 477641004393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004395 active site 477641004396 phosphorylation site [posttranslational modification] 477641004397 intermolecular recognition site; other site 477641004398 dimerization interface [polypeptide binding]; other site 477641004399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004400 DNA binding residues [nucleotide binding] 477641004401 dimerization interface [polypeptide binding]; other site 477641004402 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 477641004403 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 477641004404 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 477641004405 chaperone protein DnaJ; Provisional; Region: PRK14278 477641004406 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 477641004407 HSP70 interaction site [polypeptide binding]; other site 477641004408 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 477641004409 Zn binding sites [ion binding]; other site 477641004410 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 477641004411 dimer interface [polypeptide binding]; other site 477641004412 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 477641004413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641004414 salt bridge; other site 477641004415 non-specific DNA binding site [nucleotide binding]; other site 477641004416 sequence-specific DNA binding site [nucleotide binding]; other site 477641004417 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641004418 classical (c) SDRs; Region: SDR_c; cd05233 477641004419 NAD(P) binding site [chemical binding]; other site 477641004420 active site 477641004421 GAF domain; Region: GAF; cl17456 477641004422 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641004423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641004424 dimer interface [polypeptide binding]; other site 477641004425 putative CheW interface [polypeptide binding]; other site 477641004426 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 477641004427 nucleotide binding site/active site [active] 477641004428 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 477641004429 PhoH-like protein; Region: PhoH; pfam02562 477641004430 metal-binding heat shock protein; Provisional; Region: PRK00016 477641004431 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 477641004432 Domain of unknown function DUF21; Region: DUF21; pfam01595 477641004433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 477641004434 Transporter associated domain; Region: CorC_HlyC; smart01091 477641004435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641004436 Histidine kinase; Region: HisKA_3; pfam07730 477641004437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641004438 ATP binding site [chemical binding]; other site 477641004439 Mg2+ binding site [ion binding]; other site 477641004440 G-X-G motif; other site 477641004441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004443 active site 477641004444 phosphorylation site [posttranslational modification] 477641004445 intermolecular recognition site; other site 477641004446 dimerization interface [polypeptide binding]; other site 477641004447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004448 DNA binding residues [nucleotide binding] 477641004449 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 477641004450 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 477641004451 GTPase Era; Reviewed; Region: era; PRK00089 477641004452 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 477641004453 G1 box; other site 477641004454 GTP/Mg2+ binding site [chemical binding]; other site 477641004455 Switch I region; other site 477641004456 G2 box; other site 477641004457 Switch II region; other site 477641004458 G3 box; other site 477641004459 G4 box; other site 477641004460 G5 box; other site 477641004461 KH domain; Region: KH_2; pfam07650 477641004462 Recombination protein O N terminal; Region: RecO_N; pfam11967 477641004463 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 477641004464 Recombination protein O C terminal; Region: RecO_C; pfam02565 477641004465 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 477641004466 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 477641004467 catalytic residue [active] 477641004468 putative FPP diphosphate binding site; other site 477641004469 putative FPP binding hydrophobic cleft; other site 477641004470 dimer interface [polypeptide binding]; other site 477641004471 putative IPP diphosphate binding site; other site 477641004472 glycyl-tRNA synthetase; Provisional; Region: PRK04173 477641004473 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 477641004474 motif 1; other site 477641004475 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 477641004476 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 477641004477 active site 477641004478 motif 2; other site 477641004479 motif 3; other site 477641004480 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 477641004481 anticodon binding site; other site 477641004482 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 477641004483 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 477641004484 FMN binding site [chemical binding]; other site 477641004485 active site 477641004486 catalytic residues [active] 477641004487 substrate binding site [chemical binding]; other site 477641004488 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 477641004489 Uncharacterized conserved protein [Function unknown]; Region: COG1434 477641004490 putative active site [active] 477641004491 CHC2 zinc finger; Region: zf-CHC2; cl17510 477641004492 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 477641004493 protein-splicing catalytic site; other site 477641004494 thioester formation/cholesterol transfer; other site 477641004495 DNA primase; Validated; Region: dnaG; PRK05667 477641004496 CHC2 zinc finger; Region: zf-CHC2; cl17510 477641004497 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 477641004498 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 477641004499 active site 477641004500 metal binding site [ion binding]; metal-binding site 477641004501 interdomain interaction site; other site 477641004502 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 477641004503 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 477641004504 Hemerythrin-like domain; Region: Hr-like; cd12108 477641004505 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641004506 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641004507 active site 477641004508 catalytic tetrad [active] 477641004509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641004510 Methyltransferase domain; Region: Methyltransf_31; pfam13847 477641004511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641004512 S-adenosylmethionine binding site [chemical binding]; other site 477641004513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641004514 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 477641004515 cyclase homology domain; Region: CHD; cd07302 477641004516 nucleotidyl binding site; other site 477641004517 metal binding site [ion binding]; metal-binding site 477641004518 dimer interface [polypeptide binding]; other site 477641004519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004521 active site 477641004522 phosphorylation site [posttranslational modification] 477641004523 intermolecular recognition site; other site 477641004524 dimerization interface [polypeptide binding]; other site 477641004525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004526 DNA binding residues [nucleotide binding] 477641004527 dimerization interface [polypeptide binding]; other site 477641004528 Histidine kinase; Region: HisKA_3; pfam07730 477641004529 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641004530 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641004531 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 477641004532 Walker A/P-loop; other site 477641004533 ATP binding site [chemical binding]; other site 477641004534 Q-loop/lid; other site 477641004535 ABC transporter signature motif; other site 477641004536 Walker B; other site 477641004537 D-loop; other site 477641004538 H-loop/switch region; other site 477641004539 stage V sporulation protein K; Region: spore_V_K; TIGR02881 477641004540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641004541 Walker A motif; other site 477641004542 ATP binding site [chemical binding]; other site 477641004543 Walker B motif; other site 477641004544 arginine finger; other site 477641004545 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 477641004546 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641004547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641004548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641004549 salt bridge; other site 477641004550 non-specific DNA binding site [nucleotide binding]; other site 477641004551 sequence-specific DNA binding site [nucleotide binding]; other site 477641004552 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 477641004553 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641004554 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 477641004555 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641004556 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 477641004557 active site 477641004558 catalytic site [active] 477641004559 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 477641004560 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 477641004561 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641004562 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641004563 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641004564 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641004565 MarR family; Region: MarR_2; cl17246 477641004566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004568 DNA binding residues [nucleotide binding] 477641004569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004571 DNA binding residues [nucleotide binding] 477641004572 acyl-coenzyme A oxidase; Region: PLN02526 477641004573 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641004574 active site 477641004575 Protein of unknown function (DUF664); Region: DUF664; pfam04978 477641004576 DinB superfamily; Region: DinB_2; pfam12867 477641004577 acyl-CoA synthetase; Validated; Region: PRK05857 477641004578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641004579 acyl-activating enzyme (AAE) consensus motif; other site 477641004580 AMP binding site [chemical binding]; other site 477641004581 active site 477641004582 CoA binding site [chemical binding]; other site 477641004583 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 477641004584 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641004585 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641004586 active site 477641004587 ATP binding site [chemical binding]; other site 477641004588 substrate binding site [chemical binding]; other site 477641004589 activation loop (A-loop); other site 477641004590 Ion channel; Region: Ion_trans_2; pfam07885 477641004591 TrkA-N domain; Region: TrkA_N; pfam02254 477641004592 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 477641004593 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 477641004594 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 477641004595 Chromate transporter; Region: Chromate_transp; pfam02417 477641004596 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 477641004597 RNB domain; Region: RNB; pfam00773 477641004598 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 477641004599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004600 dimerization interface [polypeptide binding]; other site 477641004601 putative DNA binding site [nucleotide binding]; other site 477641004602 putative Zn2+ binding site [ion binding]; other site 477641004603 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641004604 CHAD domain; Region: CHAD; pfam05235 477641004605 AAA domain; Region: AAA_31; pfam13614 477641004606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641004607 P-loop; other site 477641004608 Magnesium ion binding site [ion binding]; other site 477641004609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641004610 Magnesium ion binding site [ion binding]; other site 477641004611 amphi-Trp domain; Region: amphi-Trp; TIGR04354 477641004612 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 477641004613 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 477641004614 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 477641004615 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 477641004616 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 477641004617 dimer interface [polypeptide binding]; other site 477641004618 active site 477641004619 acyl carrier protein; Provisional; Region: acpP; PRK00982 477641004620 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 477641004621 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 477641004622 dimer interface [polypeptide binding]; other site 477641004623 active site 477641004624 CoA binding pocket [chemical binding]; other site 477641004625 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 477641004626 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641004627 carboxyltransferase (CT) interaction site; other site 477641004628 biotinylation site [posttranslational modification]; other site 477641004629 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641004630 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 477641004631 active site 477641004632 Pirin; Region: Pirin; pfam02678 477641004633 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 477641004634 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 477641004635 metal binding site [ion binding]; metal-binding site 477641004636 dimer interface [polypeptide binding]; other site 477641004637 Evidence 4 : Homologs of previously reported genes of unknown function 477641004638 Evidence 4 : Homologs of previously reported genes of unknown function 477641004639 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 477641004640 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 477641004641 dimer interface [polypeptide binding]; other site 477641004642 TPP-binding site [chemical binding]; other site 477641004643 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 477641004644 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 477641004645 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 477641004646 dimer interface [polypeptide binding]; other site 477641004647 catalytic triad [active] 477641004648 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641004649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641004650 NAD(P) binding site [chemical binding]; other site 477641004651 active site 477641004652 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 477641004653 N-acetyl-D-glucosamine binding site [chemical binding]; other site 477641004654 catalytic residue [active] 477641004655 Rhodanese Homology Domain; Region: RHOD; smart00450 477641004656 active site residue [active] 477641004657 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 477641004658 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 477641004659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641004660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641004661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641004662 Walker A/P-loop; other site 477641004663 ATP binding site [chemical binding]; other site 477641004664 Q-loop/lid; other site 477641004665 ABC transporter signature motif; other site 477641004666 Walker B; other site 477641004667 D-loop; other site 477641004668 H-loop/switch region; other site 477641004669 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641004670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641004671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641004672 Walker A/P-loop; other site 477641004673 ATP binding site [chemical binding]; other site 477641004674 Q-loop/lid; other site 477641004675 ABC transporter signature motif; other site 477641004676 Walker B; other site 477641004677 D-loop; other site 477641004678 H-loop/switch region; other site 477641004679 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641004680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641004681 active site 477641004682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641004683 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 477641004684 Uncharacterized conserved protein [Function unknown]; Region: COG0327 477641004685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 477641004686 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 477641004687 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 477641004688 potential frameshift: common BLAST hit: gi|159036381|ref|YP_001535634.1| Na+/solute symporter 477641004689 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 477641004690 Na binding site [ion binding]; other site 477641004691 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 477641004692 Putative zinc ribbon domain; Region: DUF164; pfam02591 477641004693 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 477641004694 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 477641004695 RNA/DNA hybrid binding site [nucleotide binding]; other site 477641004696 active site 477641004697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641004698 catalytic core [active] 477641004699 quinolinate synthetase; Provisional; Region: PRK09375 477641004700 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 477641004701 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 477641004702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641004703 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 477641004704 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 477641004705 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 477641004706 AsnC family; Region: AsnC_trans_reg; pfam01037 477641004707 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 477641004708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641004709 putative substrate translocation pore; other site 477641004710 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 477641004711 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 477641004712 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641004713 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641004714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641004715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641004716 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 477641004717 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 477641004718 putative [4Fe-4S] binding site [ion binding]; other site 477641004719 putative molybdopterin cofactor binding site [chemical binding]; other site 477641004720 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 477641004721 molybdopterin cofactor binding site; other site 477641004722 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 477641004723 Domain of unknown function DUF20; Region: UPF0118; pfam01594 477641004724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641004725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641004726 metal binding site [ion binding]; metal-binding site 477641004727 active site 477641004728 I-site; other site 477641004729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641004730 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 477641004731 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 477641004732 ChaB; Region: ChaB; pfam06150 477641004733 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 477641004734 Ion channel; Region: Ion_trans_2; pfam07885 477641004735 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 477641004736 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 477641004737 active site 477641004738 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641004739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641004740 metal binding site [ion binding]; metal-binding site 477641004741 active site 477641004742 I-site; other site 477641004743 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 477641004744 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 477641004745 oligomerization interface [polypeptide binding]; other site 477641004746 active site 477641004747 metal binding site [ion binding]; metal-binding site 477641004748 NAD synthetase; Provisional; Region: PRK13981 477641004749 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 477641004750 multimer interface [polypeptide binding]; other site 477641004751 active site 477641004752 catalytic triad [active] 477641004753 protein interface 1 [polypeptide binding]; other site 477641004754 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 477641004755 homodimer interface [polypeptide binding]; other site 477641004756 NAD binding pocket [chemical binding]; other site 477641004757 ATP binding pocket [chemical binding]; other site 477641004758 Mg binding site [ion binding]; other site 477641004759 active-site loop [active] 477641004760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 477641004761 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 477641004762 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 477641004763 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 477641004764 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 477641004765 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 477641004766 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 477641004767 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 477641004768 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 477641004769 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 477641004770 catalytic triad [active] 477641004771 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 477641004772 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 477641004773 metal binding triad; other site 477641004774 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 477641004775 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 477641004776 metal binding triad; other site 477641004777 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 477641004778 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 477641004779 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 477641004780 Uncharacterized conserved protein [Function unknown]; Region: COG3391 477641004781 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641004782 GAF domain; Region: GAF_2; pfam13185 477641004783 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641004784 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641004785 dimer interface [polypeptide binding]; other site 477641004786 putative CheW interface [polypeptide binding]; other site 477641004787 potential frameshift: common BLAST hit: gi|386845584|ref|YP_006263597.1| major facilitator superfamily protein 477641004788 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 477641004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641004790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641004791 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 477641004792 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 477641004793 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 477641004794 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641004795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641004796 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 477641004797 DNA binding residues [nucleotide binding] 477641004798 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 477641004799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641004800 ATP binding site [chemical binding]; other site 477641004801 Mg2+ binding site [ion binding]; other site 477641004802 G-X-G motif; other site 477641004803 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 477641004804 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 477641004805 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641004806 GAF domain; Region: GAF_2; pfam13185 477641004807 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641004808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004809 dimerization interface [polypeptide binding]; other site 477641004810 putative DNA binding site [nucleotide binding]; other site 477641004811 putative Zn2+ binding site [ion binding]; other site 477641004812 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 477641004813 arsenical-resistance protein; Region: acr3; TIGR00832 477641004814 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 477641004815 Low molecular weight phosphatase family; Region: LMWPc; cl00105 477641004816 active site 477641004817 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 477641004818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641004819 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641004820 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 477641004821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 477641004822 active site 477641004823 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 477641004824 Low molecular weight phosphatase family; Region: LMWPc; cl00105 477641004825 active site 477641004826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 477641004827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004828 dimerization interface [polypeptide binding]; other site 477641004829 putative DNA binding site [nucleotide binding]; other site 477641004830 putative Zn2+ binding site [ion binding]; other site 477641004831 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 477641004832 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 477641004833 DNA binding residues [nucleotide binding] 477641004834 dimer interface [polypeptide binding]; other site 477641004835 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641004836 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641004837 catalytic residues [active] 477641004838 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004839 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004840 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 477641004841 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 477641004842 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 477641004843 putative active site [active] 477641004844 catalytic triad [active] 477641004845 putative dimer interface [polypeptide binding]; other site 477641004846 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 477641004847 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641004848 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641004849 Penicillinase repressor; Region: Pencillinase_R; pfam03965 477641004850 Peptidase family M48; Region: Peptidase_M48; cl12018 477641004851 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 477641004852 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 477641004853 Cation efflux family; Region: Cation_efflux; cl00316 477641004854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004855 dimerization interface [polypeptide binding]; other site 477641004856 putative DNA binding site [nucleotide binding]; other site 477641004857 putative Zn2+ binding site [ion binding]; other site 477641004858 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 477641004859 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 477641004860 Cu(I) binding site [ion binding]; other site 477641004861 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 477641004862 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 477641004863 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 477641004864 putative active site [active] 477641004865 redox center [active] 477641004866 Thioredoxin; Region: Thioredoxin_4; pfam13462 477641004867 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 477641004868 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 477641004869 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 477641004870 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641004871 DNA binding residues [nucleotide binding] 477641004872 hypothetical protein; Provisional; Region: PRK02237 477641004873 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 477641004874 Putative zinc-finger; Region: zf-HC2; pfam13490 477641004875 CopC domain; Region: CopC; pfam04234 477641004876 Copper resistance protein D; Region: CopD; pfam05425 477641004877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641004878 putative DNA binding site [nucleotide binding]; other site 477641004879 putative Zn2+ binding site [ion binding]; other site 477641004880 Cation efflux family; Region: Cation_efflux; cl00316 477641004881 glutamine synthetase, type I; Region: GlnA; TIGR00653 477641004882 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 477641004883 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 477641004884 RDD family; Region: RDD; pfam06271 477641004885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641004887 active site 477641004888 phosphorylation site [posttranslational modification] 477641004889 intermolecular recognition site; other site 477641004890 dimerization interface [polypeptide binding]; other site 477641004891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004892 DNA binding residues [nucleotide binding] 477641004893 dimerization interface [polypeptide binding]; other site 477641004894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641004895 Histidine kinase; Region: HisKA_3; pfam07730 477641004896 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641004897 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641004898 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 477641004899 Walker A/P-loop; other site 477641004900 ATP binding site [chemical binding]; other site 477641004901 Q-loop/lid; other site 477641004902 ABC transporter signature motif; other site 477641004903 Walker B; other site 477641004904 D-loop; other site 477641004905 H-loop/switch region; other site 477641004906 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 477641004907 lipoyl synthase; Provisional; Region: PRK05481 477641004908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641004909 FeS/SAM binding site; other site 477641004910 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 477641004911 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 477641004912 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641004913 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14245357; Product type e : enzyme 477641004914 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14245357; Product type e : enzyme 477641004915 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 477641004916 NADH(P)-binding; Region: NAD_binding_10; pfam13460 477641004917 NAD(P) binding site [chemical binding]; other site 477641004918 putative active site [active] 477641004919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004921 DNA binding residues [nucleotide binding] 477641004922 dimerization interface [polypeptide binding]; other site 477641004923 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 477641004924 homotrimer interaction site [polypeptide binding]; other site 477641004925 putative active site [active] 477641004926 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 477641004927 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 477641004928 DinB superfamily; Region: DinB_2; pfam12867 477641004929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641004930 MarR family; Region: MarR_2; pfam12802 477641004931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641004932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 477641004933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 477641004934 substrate binding pocket [chemical binding]; other site 477641004935 membrane-bound complex binding site; other site 477641004936 hinge residues; other site 477641004937 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 477641004938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641004939 dimer interface [polypeptide binding]; other site 477641004940 conserved gate region; other site 477641004941 ABC-ATPase subunit interface; other site 477641004942 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 477641004943 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 477641004944 Walker A/P-loop; other site 477641004945 ATP binding site [chemical binding]; other site 477641004946 Q-loop/lid; other site 477641004947 ABC transporter signature motif; other site 477641004948 Walker B; other site 477641004949 D-loop; other site 477641004950 H-loop/switch region; other site 477641004951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641004952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641004953 salt bridge; other site 477641004954 non-specific DNA binding site [nucleotide binding]; other site 477641004955 sequence-specific DNA binding site [nucleotide binding]; other site 477641004956 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641004957 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641004958 active site 477641004959 catalytic tetrad [active] 477641004960 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641004961 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641004962 NAD(P) binding site [chemical binding]; other site 477641004963 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 477641004964 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 477641004965 A new structural DNA glycosylase; Region: AlkD_like; cd06561 477641004966 active site 477641004967 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 477641004968 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641004969 putative NAD(P) binding site [chemical binding]; other site 477641004970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641004971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641004972 WHG domain; Region: WHG; pfam13305 477641004973 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641004974 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641004975 active site 477641004976 catalytic tetrad [active] 477641004977 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641004978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641004979 salt bridge; other site 477641004980 non-specific DNA binding site [nucleotide binding]; other site 477641004981 sequence-specific DNA binding site [nucleotide binding]; other site 477641004982 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 477641004983 GIY-YIG motif/motif A; other site 477641004984 active site 477641004985 catalytic site [active] 477641004986 putative DNA binding site [nucleotide binding]; other site 477641004987 metal binding site [ion binding]; metal-binding site 477641004988 methionine sulfoxide reductase A; Provisional; Region: PRK14054 477641004989 WHG domain; Region: WHG; pfam13305 477641004990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641004991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641004992 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 477641004993 intracellular protease, PfpI family; Region: PfpI; TIGR01382 477641004994 conserved cys residue [active] 477641004995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641004996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641004997 DNA binding residues [nucleotide binding] 477641004998 dimerization interface [polypeptide binding]; other site 477641004999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641005000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 477641005001 dimerization interface [polypeptide binding]; other site 477641005002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641005003 PAS domain; Region: PAS_9; pfam13426 477641005004 putative active site [active] 477641005005 heme pocket [chemical binding]; other site 477641005006 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641005007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 477641005008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641005009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 477641005010 dimerization interface [polypeptide binding]; other site 477641005011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641005012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005013 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 477641005014 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641005015 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 477641005016 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 477641005017 NAD binding site [chemical binding]; other site 477641005018 catalytic Zn binding site [ion binding]; other site 477641005019 structural Zn binding site [ion binding]; other site 477641005020 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 477641005021 intracellular protease, PfpI family; Region: PfpI; TIGR01382 477641005022 proposed catalytic triad [active] 477641005023 conserved cys residue [active] 477641005024 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641005025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641005026 NAD binding site [chemical binding]; other site 477641005027 catalytic Zn binding site [ion binding]; other site 477641005028 structural Zn binding site [ion binding]; other site 477641005029 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 477641005030 GAF domain; Region: GAF_3; pfam13492 477641005031 GAF domain; Region: GAF_2; pfam13185 477641005032 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 477641005033 Predicted membrane protein [Function unknown]; Region: COG4325 477641005034 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641005035 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641005036 NAD binding site [chemical binding]; other site 477641005037 catalytic Zn binding site [ion binding]; other site 477641005038 structural Zn binding site [ion binding]; other site 477641005039 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 477641005040 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641005041 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 477641005042 Cupin domain; Region: Cupin_2; pfam07883 477641005043 AAA ATPase domain; Region: AAA_16; pfam13191 477641005044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641005045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641005046 DNA binding residues [nucleotide binding] 477641005047 dimerization interface [polypeptide binding]; other site 477641005048 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 477641005049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005050 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641005051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641005052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641005053 salt bridge; other site 477641005054 non-specific DNA binding site [nucleotide binding]; other site 477641005055 sequence-specific DNA binding site [nucleotide binding]; other site 477641005056 short chain dehydrogenase; Provisional; Region: PRK06940 477641005057 classical (c) SDRs; Region: SDR_c; cd05233 477641005058 NAD(P) binding site [chemical binding]; other site 477641005059 active site 477641005060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005061 WHG domain; Region: WHG; pfam13305 477641005062 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 477641005063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641005064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641005065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641005067 active site 477641005068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641005069 catalytic tetrad [active] 477641005070 Amidase; Region: Amidase; cl11426 477641005071 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641005072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641005073 active site 477641005074 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 477641005075 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641005076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641005077 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 477641005078 YCII-related domain; Region: YCII; cl00999 477641005079 DNA binding domain, excisionase family; Region: excise; TIGR01764 477641005080 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641005081 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 477641005082 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 477641005083 dimer interface [polypeptide binding]; other site 477641005084 ADP-ribose binding site [chemical binding]; other site 477641005085 active site 477641005086 nudix motif; other site 477641005087 metal binding site [ion binding]; metal-binding site 477641005088 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 477641005089 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 477641005090 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 477641005091 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 477641005092 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 477641005093 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 477641005094 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 477641005095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005096 NAD(P) binding site [chemical binding]; other site 477641005097 active site 477641005098 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 477641005099 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641005100 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641005101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641005102 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 477641005103 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 477641005104 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641005105 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 477641005106 Predicted ATPase [General function prediction only]; Region: COG3903 477641005107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641005108 active site 477641005109 phosphorylation site [posttranslational modification] 477641005110 intermolecular recognition site; other site 477641005111 dimerization interface [polypeptide binding]; other site 477641005112 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 477641005113 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 477641005114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641005115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641005116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 477641005117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641005118 ligand binding site [chemical binding]; other site 477641005119 flexible hinge region; other site 477641005120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641005121 ATP binding site [chemical binding]; other site 477641005122 Mg2+ binding site [ion binding]; other site 477641005123 G-X-G motif; other site 477641005124 cyclase homology domain; Region: CHD; cd07302 477641005125 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 477641005126 nucleotidyl binding site; other site 477641005127 metal binding site [ion binding]; metal-binding site 477641005128 dimer interface [polypeptide binding]; other site 477641005129 AAA ATPase domain; Region: AAA_16; pfam13191 477641005130 short chain dehydrogenase; Provisional; Region: PRK07109 477641005131 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 477641005132 putative NAD(P) binding site [chemical binding]; other site 477641005133 active site 477641005134 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 477641005135 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 477641005136 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 477641005137 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 477641005138 NAD(P) binding site [chemical binding]; other site 477641005139 homotetramer interface [polypeptide binding]; other site 477641005140 homodimer interface [polypeptide binding]; other site 477641005141 active site 477641005142 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 477641005143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005144 NAD(P) binding site [chemical binding]; other site 477641005145 active site 477641005146 ferrochelatase; Reviewed; Region: hemH; PRK00035 477641005147 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 477641005148 C-terminal domain interface [polypeptide binding]; other site 477641005149 active site 477641005150 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 477641005151 active site 477641005152 N-terminal domain interface [polypeptide binding]; other site 477641005153 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641005154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005155 active site 477641005156 metal binding site [ion binding]; metal-binding site 477641005157 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 477641005158 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 477641005159 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 477641005160 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 477641005161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641005162 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 477641005163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641005164 DNA binding residues [nucleotide binding] 477641005165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 477641005166 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641005167 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 477641005168 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 477641005169 active site 477641005170 DNA binding site [nucleotide binding] 477641005171 Int/Topo IB signature motif; other site 477641005172 catalytic residues [active] 477641005173 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641005174 anti sigma factor interaction site; other site 477641005175 regulatory phosphorylation site [posttranslational modification]; other site 477641005176 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 477641005177 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 477641005178 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 477641005179 putative DNA binding site [nucleotide binding]; other site 477641005180 putative homodimer interface [polypeptide binding]; other site 477641005181 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 477641005182 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 477641005183 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 477641005184 active site 477641005185 DNA binding site [nucleotide binding] 477641005186 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 477641005187 DNA binding site [nucleotide binding] 477641005188 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 477641005189 nucleotide binding site [chemical binding]; other site 477641005190 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 477641005191 metal binding site 2 [ion binding]; metal-binding site 477641005192 putative DNA binding helix; other site 477641005193 metal binding site 1 [ion binding]; metal-binding site 477641005194 dimer interface [polypeptide binding]; other site 477641005195 structural Zn2+ binding site [ion binding]; other site 477641005196 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 477641005197 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 477641005198 tetramer interface [polypeptide binding]; other site 477641005199 heme binding pocket [chemical binding]; other site 477641005200 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 477641005201 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 477641005202 heme-binding site [chemical binding]; other site 477641005203 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 477641005204 FAD binding pocket [chemical binding]; other site 477641005205 FAD binding motif [chemical binding]; other site 477641005206 phosphate binding motif [ion binding]; other site 477641005207 beta-alpha-beta structure motif; other site 477641005208 NAD binding pocket [chemical binding]; other site 477641005209 Heme binding pocket [chemical binding]; other site 477641005210 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641005211 PAC2 family; Region: PAC2; pfam09754 477641005212 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 477641005213 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 477641005214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641005215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641005216 non-specific DNA binding site [nucleotide binding]; other site 477641005217 salt bridge; other site 477641005218 sequence-specific DNA binding site [nucleotide binding]; other site 477641005219 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 477641005220 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 477641005221 putative active site [active] 477641005222 Dienelactone hydrolase family; Region: DLH; pfam01738 477641005223 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 477641005224 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 477641005225 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 477641005226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641005228 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 477641005229 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 477641005230 active site 477641005231 catalytic site [active] 477641005232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005233 putative substrate translocation pore; other site 477641005234 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641005235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641005236 DNA-binding site [nucleotide binding]; DNA binding site 477641005237 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 477641005238 tyramine oxidase; Provisional; Region: tynA; PRK11504 477641005239 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 477641005240 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 477641005241 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 477641005242 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641005243 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 477641005244 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 477641005245 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 477641005246 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 477641005247 putative active site [active] 477641005248 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 477641005249 hypothetical protein; Provisional; Region: PRK05463 477641005250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641005251 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 477641005252 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 477641005253 glucose-1-dehydrogenase; Provisional; Region: PRK06947 477641005254 classical (c) SDRs; Region: SDR_c; cd05233 477641005255 NAD(P) binding site [chemical binding]; other site 477641005256 active site 477641005257 pyruvate dehydrogenase; Provisional; Region: PRK06546 477641005258 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 477641005259 PYR/PP interface [polypeptide binding]; other site 477641005260 dimer interface [polypeptide binding]; other site 477641005261 tetramer interface [polypeptide binding]; other site 477641005262 TPP binding site [chemical binding]; other site 477641005263 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 477641005264 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 477641005265 TPP-binding site [chemical binding]; other site 477641005266 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 477641005267 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 477641005268 Predicted methyltransferase [General function prediction only]; Region: COG3897 477641005269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 477641005270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 477641005271 catalytic residue [active] 477641005272 Uncharacterized conserved protein [Function unknown]; Region: COG2353 477641005273 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641005274 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641005275 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641005276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641005277 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 477641005278 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 477641005279 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 477641005280 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641005281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641005282 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641005283 non-specific DNA binding site [nucleotide binding]; other site 477641005284 salt bridge; other site 477641005285 sequence-specific DNA binding site [nucleotide binding]; other site 477641005286 TIGR04222 domain; Region: near_uncomplex 477641005287 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 477641005288 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 477641005289 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 477641005290 active site 477641005291 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 477641005292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641005293 active site 477641005294 PAS domain; Region: PAS_9; pfam13426 477641005295 PAS domain S-box; Region: sensory_box; TIGR00229 477641005296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641005297 putative active site [active] 477641005298 heme pocket [chemical binding]; other site 477641005299 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641005300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641005301 metal binding site [ion binding]; metal-binding site 477641005302 active site 477641005303 I-site; other site 477641005304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641005305 HDOD domain; Region: HDOD; pfam08668 477641005306 amidase; Provisional; Region: PRK08137 477641005307 Amidase; Region: Amidase; cl11426 477641005308 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 477641005309 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 477641005310 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641005311 active site 477641005312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005313 HTH domain; Region: HTH_11; pfam08279 477641005314 WYL domain; Region: WYL; pfam13280 477641005315 PhoD-like phosphatase; Region: PhoD; pfam09423 477641005316 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 477641005317 putative active site [active] 477641005318 putative metal binding site [ion binding]; other site 477641005319 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 477641005320 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 477641005321 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 477641005322 NAD(P) binding site [chemical binding]; other site 477641005323 catalytic residues [active] 477641005324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641005325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641005326 active site 477641005327 catalytic tetrad [active] 477641005328 amino acid transporter; Region: 2A0306; TIGR00909 477641005329 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 477641005330 Domain of unknown function (DUF336); Region: DUF336; cl01249 477641005331 pyridoxamine kinase; Validated; Region: PRK05756 477641005332 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 477641005333 dimer interface [polypeptide binding]; other site 477641005334 pyridoxal binding site [chemical binding]; other site 477641005335 ATP binding site [chemical binding]; other site 477641005336 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641005337 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 477641005338 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 477641005339 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 477641005340 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641005341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641005342 catalytic residue [active] 477641005343 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 477641005344 active site 477641005345 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 477641005346 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 477641005347 active site clefts [active] 477641005348 zinc binding site [ion binding]; other site 477641005349 dimer interface [polypeptide binding]; other site 477641005350 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 477641005351 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641005352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 477641005353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 477641005354 substrate binding pocket [chemical binding]; other site 477641005355 membrane-bound complex binding site; other site 477641005356 hinge residues; other site 477641005357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 477641005358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 477641005359 substrate binding pocket [chemical binding]; other site 477641005360 membrane-bound complex binding site; other site 477641005361 hinge residues; other site 477641005362 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 477641005363 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 477641005364 Walker A/P-loop; other site 477641005365 ATP binding site [chemical binding]; other site 477641005366 Q-loop/lid; other site 477641005367 ABC transporter signature motif; other site 477641005368 Walker B; other site 477641005369 D-loop; other site 477641005370 H-loop/switch region; other site 477641005371 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641005372 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 477641005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641005374 dimer interface [polypeptide binding]; other site 477641005375 conserved gate region; other site 477641005376 putative PBP binding loops; other site 477641005377 ABC-ATPase subunit interface; other site 477641005378 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 477641005379 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641005380 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 477641005381 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 477641005382 active site 477641005383 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 477641005384 non-prolyl cis peptide bond; other site 477641005385 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 477641005386 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 477641005387 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 477641005388 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641005389 active site 477641005390 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005391 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 477641005392 putative metal binding residues [ion binding]; other site 477641005393 signature motif; other site 477641005394 dimer interface [polypeptide binding]; other site 477641005395 active site 477641005396 polyP binding site; other site 477641005397 substrate binding site [chemical binding]; other site 477641005398 acceptor-phosphate pocket; other site 477641005399 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 477641005400 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 477641005401 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641005402 active site 477641005403 metal binding site [ion binding]; metal-binding site 477641005404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641005406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641005407 hypothetical protein; Provisional; Region: PRK06126 477641005408 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641005409 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641005410 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 477641005411 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 477641005412 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 477641005413 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641005414 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641005415 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 477641005416 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 477641005417 inhibitor site; inhibition site 477641005418 active site 477641005419 dimer interface [polypeptide binding]; other site 477641005420 catalytic residue [active] 477641005421 Dehydratase family; Region: ILVD_EDD; cl00340 477641005422 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641005423 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641005424 NAD(P) binding site [chemical binding]; other site 477641005425 MULE transposase domain; Region: MULE; pfam10551 477641005426 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 477641005427 beta-galactosidase; Region: BGL; TIGR03356 477641005428 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 477641005429 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641005430 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641005431 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641005432 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641005433 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 477641005434 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641005435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641005437 dimer interface [polypeptide binding]; other site 477641005438 conserved gate region; other site 477641005439 putative PBP binding loops; other site 477641005440 ABC-ATPase subunit interface; other site 477641005441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641005442 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 477641005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641005444 dimer interface [polypeptide binding]; other site 477641005445 conserved gate region; other site 477641005446 putative PBP binding loops; other site 477641005447 ABC-ATPase subunit interface; other site 477641005448 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641005449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641005450 Walker A/P-loop; other site 477641005451 ATP binding site [chemical binding]; other site 477641005452 Q-loop/lid; other site 477641005453 ABC transporter signature motif; other site 477641005454 Walker B; other site 477641005455 D-loop; other site 477641005456 H-loop/switch region; other site 477641005457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 477641005458 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 477641005459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641005460 Walker A/P-loop; other site 477641005461 ATP binding site [chemical binding]; other site 477641005462 Q-loop/lid; other site 477641005463 ABC transporter signature motif; other site 477641005464 Walker B; other site 477641005465 D-loop; other site 477641005466 H-loop/switch region; other site 477641005467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641005468 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 477641005469 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 477641005470 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641005471 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641005472 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 477641005473 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 477641005474 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 477641005475 inhibitor binding site; inhibition site 477641005476 active site 477641005477 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 477641005478 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 477641005479 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 477641005480 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 477641005481 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 477641005482 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 477641005483 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 477641005484 glucuronate isomerase; Reviewed; Region: PRK02925 477641005485 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 477641005486 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 477641005487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641005488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641005489 DNA binding site [nucleotide binding] 477641005490 domain linker motif; other site 477641005491 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 477641005492 dimerization interface [polypeptide binding]; other site 477641005493 ligand binding site [chemical binding]; other site 477641005494 beta-D-glucuronidase; Provisional; Region: PRK10150 477641005495 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 477641005496 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 477641005497 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 477641005498 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 477641005499 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641005500 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641005501 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641005502 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641005503 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 477641005504 active site 477641005505 catalytic triad [active] 477641005506 oxyanion hole [active] 477641005507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641005508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005509 putative substrate translocation pore; other site 477641005510 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641005511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641005513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641005514 Coenzyme A binding pocket [chemical binding]; other site 477641005515 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 477641005516 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 477641005517 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 477641005518 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 477641005519 acyl-activating enzyme (AAE) consensus motif; other site 477641005520 putative AMP binding site [chemical binding]; other site 477641005521 putative active site [active] 477641005522 putative CoA binding site [chemical binding]; other site 477641005523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641005524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005525 NAD(P) binding site [chemical binding]; other site 477641005526 active site 477641005527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641005528 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 477641005529 catalytic site [active] 477641005530 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 477641005531 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 477641005532 substrate binding site [chemical binding]; other site 477641005533 ATP binding site [chemical binding]; other site 477641005534 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641005535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005536 NAD(P) binding site [chemical binding]; other site 477641005537 active site 477641005538 aminotransferase; Validated; Region: PRK07777 477641005539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641005540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641005541 homodimer interface [polypeptide binding]; other site 477641005542 catalytic residue [active] 477641005543 Predicted amidohydrolase [General function prediction only]; Region: COG0388 477641005544 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 477641005545 active site 477641005546 catalytic triad [active] 477641005547 dimer interface [polypeptide binding]; other site 477641005548 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 477641005549 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 477641005550 dimer interface [polypeptide binding]; other site 477641005551 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 477641005552 active site 477641005553 Fe binding site [ion binding]; other site 477641005554 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 477641005555 putative DNA binding site [nucleotide binding]; other site 477641005556 AsnC family; Region: AsnC_trans_reg; pfam01037 477641005557 Protein of unknown function DUF72; Region: DUF72; pfam01904 477641005558 imidazolonepropionase; Provisional; Region: PRK14085 477641005559 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641005560 active site 477641005561 allantoate amidohydrolase; Reviewed; Region: PRK09290 477641005562 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 477641005563 metal binding site [ion binding]; metal-binding site 477641005564 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 477641005565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641005566 active site 477641005567 urocanate hydratase; Provisional; Region: PRK05414 477641005568 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 477641005569 active sites [active] 477641005570 tetramer interface [polypeptide binding]; other site 477641005571 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641005572 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641005573 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641005574 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 477641005575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005576 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 477641005577 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 477641005578 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 477641005579 apolar tunnel; other site 477641005580 heme binding site [chemical binding]; other site 477641005581 dimerization interface [polypeptide binding]; other site 477641005582 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641005583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005584 NAD(P) binding site [chemical binding]; other site 477641005585 active site 477641005586 haloalkane dehalogenase; Provisional; Region: PRK00870 477641005587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641005588 AMP-binding enzyme; Region: AMP-binding; pfam00501 477641005589 acyl-activating enzyme (AAE) consensus motif; other site 477641005590 active site 477641005591 AMP binding site [chemical binding]; other site 477641005592 CoA binding site [chemical binding]; other site 477641005593 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 477641005594 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 477641005595 dimer interface [polypeptide binding]; other site 477641005596 active site 477641005597 CoA binding pocket [chemical binding]; other site 477641005598 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641005599 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 477641005600 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641005601 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 477641005602 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 477641005603 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 477641005604 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641005605 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641005606 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641005607 Cytochrome P450; Region: p450; cl12078 477641005608 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641005609 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641005610 NAD binding site [chemical binding]; other site 477641005611 catalytic Zn binding site [ion binding]; other site 477641005612 structural Zn binding site [ion binding]; other site 477641005613 Domain of unknown function DUF20; Region: UPF0118; pfam01594 477641005614 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 477641005615 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 477641005616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641005617 putative ADP-binding pocket [chemical binding]; other site 477641005618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641005619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641005620 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641005621 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 477641005622 NAD binding site [chemical binding]; other site 477641005623 substrate binding site [chemical binding]; other site 477641005624 catalytic Zn binding site [ion binding]; other site 477641005625 structural Zn binding site [ion binding]; other site 477641005626 Domain of unknown function DUF59; Region: DUF59; pfam01883 477641005627 Amidohydrolase; Region: Amidohydro_2; pfam04909 477641005628 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 477641005629 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641005630 extended (e) SDRs; Region: SDR_e; cd08946 477641005631 NAD(P) binding site [chemical binding]; other site 477641005632 active site 477641005633 substrate binding site [chemical binding]; other site 477641005634 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 477641005635 active site 477641005636 SUMO-1 interface [polypeptide binding]; other site 477641005637 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 477641005638 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 477641005639 amidohydrolase; Region: amidohydrolases; TIGR01891 477641005640 metal binding site [ion binding]; metal-binding site 477641005641 Ion channel; Region: Ion_trans_2; pfam07885 477641005642 TrkA-N domain; Region: TrkA_N; pfam02254 477641005643 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 477641005644 TrkA-N domain; Region: TrkA_N; pfam02254 477641005645 FtsH Extracellular; Region: FtsH_ext; pfam06480 477641005646 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 477641005647 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 477641005648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641005649 Walker A motif; other site 477641005650 ATP binding site [chemical binding]; other site 477641005651 Walker B motif; other site 477641005652 arginine finger; other site 477641005653 Peptidase family M41; Region: Peptidase_M41; pfam01434 477641005654 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 477641005655 CoA-transferase family III; Region: CoA_transf_3; pfam02515 477641005656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005657 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 477641005658 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641005659 NAD(P) binding site [chemical binding]; other site 477641005660 active site 477641005661 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 477641005662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641005663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 477641005664 nucleotide binding site [chemical binding]; other site 477641005665 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641005666 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641005667 Walker A/P-loop; other site 477641005668 ATP binding site [chemical binding]; other site 477641005669 Q-loop/lid; other site 477641005670 ABC transporter signature motif; other site 477641005671 Walker B; other site 477641005672 D-loop; other site 477641005673 H-loop/switch region; other site 477641005674 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641005675 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641005676 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641005677 TM-ABC transporter signature motif; other site 477641005678 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641005679 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 477641005680 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641005681 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641005682 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641005683 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 477641005684 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 477641005685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641005686 S-adenosylmethionine binding site [chemical binding]; other site 477641005687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641005688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641005689 DNA binding residues [nucleotide binding] 477641005690 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 477641005691 FAD binding domain; Region: FAD_binding_4; pfam01565 477641005692 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 477641005693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641005694 dimerization interface [polypeptide binding]; other site 477641005695 putative DNA binding site [nucleotide binding]; other site 477641005696 putative Zn2+ binding site [ion binding]; other site 477641005697 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 477641005698 putative hydrophobic ligand binding site [chemical binding]; other site 477641005699 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 477641005700 classical (c) SDRs; Region: SDR_c; cd05233 477641005701 NAD(P) binding site [chemical binding]; other site 477641005702 active site 477641005703 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 477641005704 classical (c) SDRs; Region: SDR_c; cd05233 477641005705 NAD(P) binding site [chemical binding]; other site 477641005706 active site 477641005707 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641005708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005709 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641005710 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 477641005711 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 477641005712 potential frameshift: common BLAST hit: gi|284992178|ref|YP_003410732.1| HNH endonuclease 477641005713 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641005714 active site 477641005715 RibD C-terminal domain; Region: RibD_C; cl17279 477641005716 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 477641005717 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 477641005718 active site 477641005719 DNA binding site [nucleotide binding] 477641005720 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 477641005721 DNA binding site [nucleotide binding] 477641005722 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641005723 FAD binding domain; Region: FAD_binding_4; pfam01565 477641005724 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 477641005725 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 477641005726 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 477641005727 active site 477641005728 NAD binding site [chemical binding]; other site 477641005729 metal binding site [ion binding]; metal-binding site 477641005730 Cupin domain; Region: Cupin_2; pfam07883 477641005731 Helix-turn-helix domain; Region: HTH_18; pfam12833 477641005732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641005733 Predicted thioesterase [General function prediction only]; Region: COG5496 477641005734 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 477641005735 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 477641005736 FAD binding pocket [chemical binding]; other site 477641005737 FAD binding motif [chemical binding]; other site 477641005738 phosphate binding motif [ion binding]; other site 477641005739 beta-alpha-beta structure motif; other site 477641005740 NAD(p) ribose binding residues [chemical binding]; other site 477641005741 NAD binding pocket [chemical binding]; other site 477641005742 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 477641005743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641005744 catalytic loop [active] 477641005745 iron binding site [ion binding]; other site 477641005746 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 477641005747 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 477641005748 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 477641005749 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 477641005750 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 477641005751 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 477641005752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641005753 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 477641005754 acyl-activating enzyme (AAE) consensus motif; other site 477641005755 AMP binding site [chemical binding]; other site 477641005756 active site 477641005757 CoA binding site [chemical binding]; other site 477641005758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641005759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005760 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 477641005761 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 477641005762 substrate binding site [chemical binding]; other site 477641005763 dimer interface [polypeptide binding]; other site 477641005764 NADP binding site [chemical binding]; other site 477641005765 catalytic residues [active] 477641005766 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 477641005767 active site 2 [active] 477641005768 active site 1 [active] 477641005769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641005770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005771 active site 477641005772 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641005773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641005774 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 477641005775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641005776 ligand binding site [chemical binding]; other site 477641005777 flexible hinge region; other site 477641005778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641005779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641005780 ATP binding site [chemical binding]; other site 477641005781 Mg2+ binding site [ion binding]; other site 477641005782 G-X-G motif; other site 477641005783 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 477641005784 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 477641005785 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 477641005786 active site 477641005787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 477641005788 serine/threonine protein kinase; Provisional; Region: PRK14879 477641005789 Predicted integral membrane protein [Function unknown]; Region: COG0392 477641005790 PAP2 superfamily; Region: PAP2; pfam01569 477641005791 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 477641005792 active site 477641005793 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641005794 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641005795 ATP binding site [chemical binding]; other site 477641005796 Mg2+ binding site [ion binding]; other site 477641005797 G-X-G motif; other site 477641005798 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 477641005799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641005800 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 477641005801 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 477641005802 D-pathway; other site 477641005803 Low-spin heme binding site [chemical binding]; other site 477641005804 Putative water exit pathway; other site 477641005805 Binuclear center (active site) [active] 477641005806 K-pathway; other site 477641005807 Putative proton exit pathway; other site 477641005808 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641005809 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 477641005810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641005811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641005812 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 477641005813 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 477641005814 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 477641005815 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 477641005816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641005817 active site 477641005818 metal binding site [ion binding]; metal-binding site 477641005819 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641005820 active site 477641005821 metal binding site [ion binding]; metal-binding site 477641005822 hypothetical protein; Provisional; Region: PRK06847 477641005823 hypothetical protein; Provisional; Region: PRK07236 477641005824 Putative cyclase; Region: Cyclase; pfam04199 477641005825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 477641005826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641005827 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 477641005828 substrate binding pocket [chemical binding]; other site 477641005829 dimerization interface [polypeptide binding]; other site 477641005830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641005832 putative substrate translocation pore; other site 477641005833 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641005834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005835 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 477641005836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641005837 PAS domain; Region: PAS_9; pfam13426 477641005838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641005839 putative active site [active] 477641005840 heme pocket [chemical binding]; other site 477641005841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641005842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641005843 metal binding site [ion binding]; metal-binding site 477641005844 active site 477641005845 I-site; other site 477641005846 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 477641005847 active site 477641005848 catalytic residues [active] 477641005849 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 477641005850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641005851 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 477641005852 Uncharacterized conserved protein [Function unknown]; Region: COG0397 477641005853 hypothetical protein; Validated; Region: PRK00029 477641005854 Methyltransferase domain; Region: Methyltransf_11; pfam08241 477641005855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641005856 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 477641005857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641005858 substrate binding site [chemical binding]; other site 477641005859 oxyanion hole (OAH) forming residues; other site 477641005860 trimer interface [polypeptide binding]; other site 477641005861 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641005862 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641005863 Walker A/P-loop; other site 477641005864 ATP binding site [chemical binding]; other site 477641005865 Q-loop/lid; other site 477641005866 ABC transporter signature motif; other site 477641005867 Walker B; other site 477641005868 D-loop; other site 477641005869 H-loop/switch region; other site 477641005870 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 477641005871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641005872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641005873 DNA binding residues [nucleotide binding] 477641005874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641005877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641005878 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 477641005879 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 477641005880 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 477641005881 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 477641005882 NAD(P) binding site [chemical binding]; other site 477641005883 catalytic residues [active] 477641005884 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641005885 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 477641005886 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 477641005887 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 477641005888 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 477641005889 hypothetical protein; Provisional; Region: PRK08296 477641005890 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 477641005891 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641005892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641005893 DNA-binding site [nucleotide binding]; DNA binding site 477641005894 FCD domain; Region: FCD; pfam07729 477641005895 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 477641005896 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641005897 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641005898 Walker A/P-loop; other site 477641005899 ATP binding site [chemical binding]; other site 477641005900 Q-loop/lid; other site 477641005901 ABC transporter signature motif; other site 477641005902 Walker B; other site 477641005903 D-loop; other site 477641005904 H-loop/switch region; other site 477641005905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641005906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641005907 TM-ABC transporter signature motif; other site 477641005908 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641005909 TM-ABC transporter signature motif; other site 477641005910 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 477641005911 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 477641005912 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641005913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641005914 DNA-binding site [nucleotide binding]; DNA binding site 477641005915 FCD domain; Region: FCD; pfam07729 477641005916 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 477641005917 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 477641005918 tetrameric interface [polypeptide binding]; other site 477641005919 NAD binding site [chemical binding]; other site 477641005920 catalytic residues [active] 477641005921 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641005922 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641005923 Transaldolase; Region: Transaldolase; pfam00923 477641005924 catalytic residue [active] 477641005925 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 477641005926 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641005927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641005928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641005929 active site 477641005930 phosphorylation site [posttranslational modification] 477641005931 intermolecular recognition site; other site 477641005932 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 477641005933 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 477641005934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641005935 DNA binding residues [nucleotide binding] 477641005936 Putative zinc-finger; Region: zf-HC2; pfam13490 477641005937 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641005938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641005939 Walker A/P-loop; other site 477641005940 ATP binding site [chemical binding]; other site 477641005941 Q-loop/lid; other site 477641005942 ABC transporter signature motif; other site 477641005943 Walker B; other site 477641005944 D-loop; other site 477641005945 H-loop/switch region; other site 477641005946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641005947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641005948 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 477641005949 Integrase core domain; Region: rve; pfam00665 477641005950 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 477641005951 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 477641005952 Helix-turn-helix domain; Region: HTH_38; pfam13936 477641005953 Homeodomain-like domain; Region: HTH_32; pfam13565 477641005954 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 477641005955 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 477641005956 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 477641005957 catalytic Zn binding site [ion binding]; other site 477641005958 NAD binding site [chemical binding]; other site 477641005959 structural Zn binding site [ion binding]; other site 477641005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641005961 glucose-1-dehydrogenase; Provisional; Region: PRK06947 477641005962 NAD(P) binding site [chemical binding]; other site 477641005963 active site 477641005964 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 477641005965 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 477641005966 hypothetical protein; Provisional; Region: PRK02399 477641005967 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 477641005968 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 477641005969 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641005970 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641005971 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641005972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641005973 catalytic loop [active] 477641005974 iron binding site [ion binding]; other site 477641005975 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641005976 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 477641005977 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 477641005978 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641005979 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641005980 NAD(P) binding site [chemical binding]; other site 477641005981 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641005982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641005983 DNA-binding site [nucleotide binding]; DNA binding site 477641005984 FCD domain; Region: FCD; pfam07729 477641005985 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 477641005986 Putative cyclase; Region: Cyclase; pfam04199 477641005987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641005988 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 477641005989 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 477641005990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641005991 motif II; other site 477641005992 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 477641005993 putative pectinesterase; Region: PLN02432; cl01911 477641005994 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 477641005995 MarR family; Region: MarR; pfam01047 477641005996 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641005997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641005998 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 477641005999 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 477641006000 active site 477641006001 catalytic site [active] 477641006002 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641006003 hypothetical protein; Provisional; Region: PRK10621 477641006004 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 477641006005 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 477641006006 Tannase and feruloyl esterase; Region: Tannase; pfam07519 477641006007 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 477641006008 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 477641006009 putative active site [active] 477641006010 putative dimer interface [polypeptide binding]; other site 477641006011 adenylate kinase; Reviewed; Region: adk; PRK00279 477641006012 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 477641006013 AMP-binding site [chemical binding]; other site 477641006014 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 477641006015 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 477641006016 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 477641006017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641006018 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641006019 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 477641006020 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641006021 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 477641006022 NADP binding site [chemical binding]; other site 477641006023 dimer interface [polypeptide binding]; other site 477641006024 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 477641006025 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641006026 Epoxide hydrolase N terminus; Region: EHN; pfam06441 477641006027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641006028 AAA ATPase domain; Region: AAA_16; pfam13191 477641006029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006030 DNA binding residues [nucleotide binding] 477641006031 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006032 dimerization interface [polypeptide binding]; other site 477641006033 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 477641006034 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 477641006035 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 477641006036 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 477641006037 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 477641006038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641006039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641006040 DNA binding residues [nucleotide binding] 477641006041 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 477641006042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641006043 catalytic loop [active] 477641006044 iron binding site [ion binding]; other site 477641006045 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 477641006046 L-aspartate oxidase; Provisional; Region: PRK06175 477641006047 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 477641006048 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 477641006049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641006050 active site 477641006051 DNA binding site [nucleotide binding] 477641006052 Int/Topo IB signature motif; other site 477641006053 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 477641006054 NADH(P)-binding; Region: NAD_binding_10; pfam13460 477641006055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641006056 NAD(P) binding site [chemical binding]; other site 477641006057 active site 477641006058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641006059 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 477641006060 Walker A/P-loop; other site 477641006061 ATP binding site [chemical binding]; other site 477641006062 Q-loop/lid; other site 477641006063 ABC transporter signature motif; other site 477641006064 Walker B; other site 477641006065 D-loop; other site 477641006066 H-loop/switch region; other site 477641006067 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641006068 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641006069 Transglycosylase; Region: Transgly; pfam00912 477641006070 MMPL family; Region: MMPL; pfam03176 477641006071 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 477641006072 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 477641006073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006074 putative substrate translocation pore; other site 477641006075 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641006076 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 477641006077 putative NAD(P) binding site [chemical binding]; other site 477641006078 putative substrate binding site [chemical binding]; other site 477641006079 catalytic Zn binding site [ion binding]; other site 477641006080 structural Zn binding site [ion binding]; other site 477641006081 dimer interface [polypeptide binding]; other site 477641006082 Helix-turn-helix domain; Region: HTH_31; pfam13560 477641006083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006084 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 477641006085 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641006086 ligand binding site [chemical binding]; other site 477641006087 flexible hinge region; other site 477641006088 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 477641006089 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 477641006090 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 477641006091 intersubunit interface [polypeptide binding]; other site 477641006092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641006093 putative DNA binding site [nucleotide binding]; other site 477641006094 dimerization interface [polypeptide binding]; other site 477641006095 putative Zn2+ binding site [ion binding]; other site 477641006096 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 477641006097 metal binding site 2 [ion binding]; metal-binding site 477641006098 putative DNA binding helix; other site 477641006099 metal binding site 1 [ion binding]; metal-binding site 477641006100 dimer interface [polypeptide binding]; other site 477641006101 structural Zn2+ binding site [ion binding]; other site 477641006102 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641006103 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641006104 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 477641006105 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 477641006106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006107 putative substrate translocation pore; other site 477641006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641006110 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 477641006111 NAD(P) binding site [chemical binding]; other site 477641006112 homotetramer interface [polypeptide binding]; other site 477641006113 homodimer interface [polypeptide binding]; other site 477641006114 active site 477641006115 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 477641006116 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641006117 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641006118 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 477641006119 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641006120 carboxyltransferase (CT) interaction site; other site 477641006121 biotinylation site [posttranslational modification]; other site 477641006122 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 477641006123 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 477641006124 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 477641006125 active site 477641006126 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641006127 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 477641006128 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 477641006129 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641006130 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641006131 fumarylacetoacetase; Region: PLN02856 477641006132 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 477641006133 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 477641006134 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 477641006135 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 477641006136 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641006137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641006138 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641006139 Cytochrome P450; Region: p450; cl12078 477641006140 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641006141 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641006142 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 477641006143 L-fucose transporter; Provisional; Region: PRK10133; cl17665 477641006144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 477641006145 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 477641006146 putative substrate binding site [chemical binding]; other site 477641006147 putative ATP binding site [chemical binding]; other site 477641006148 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 477641006149 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 477641006150 ligand binding site; other site 477641006151 oligomer interface; other site 477641006152 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 477641006153 dimer interface [polypeptide binding]; other site 477641006154 N-terminal domain interface [polypeptide binding]; other site 477641006155 sulfate 1 binding site; other site 477641006156 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 477641006157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 477641006158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641006159 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641006160 active site 477641006161 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 477641006162 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641006163 TAP-like protein; Region: Abhydrolase_4; pfam08386 477641006164 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 477641006165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641006166 PAS domain; Region: PAS_9; pfam13426 477641006167 putative active site [active] 477641006168 heme pocket [chemical binding]; other site 477641006169 PAS domain S-box; Region: sensory_box; TIGR00229 477641006170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641006171 putative active site [active] 477641006172 heme pocket [chemical binding]; other site 477641006173 ANTAR domain; Region: ANTAR; pfam03861 477641006174 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 477641006175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006177 DNA binding residues [nucleotide binding] 477641006178 dimerization interface [polypeptide binding]; other site 477641006179 Bacterial transcriptional activator domain; Region: BTAD; smart01043 477641006180 Bacterial transcriptional activator domain; Region: BTAD; smart01043 477641006181 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 477641006182 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 477641006183 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 477641006184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641006185 Walker A motif; other site 477641006186 ATP binding site [chemical binding]; other site 477641006187 Walker B motif; other site 477641006188 arginine finger; other site 477641006189 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 477641006190 Protein of unknown function, DUF417; Region: DUF417; cl01162 477641006191 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641006192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641006193 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 477641006194 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 477641006195 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 477641006196 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 477641006197 putative heme binding site [chemical binding]; other site 477641006198 putative substrate binding site [chemical binding]; other site 477641006199 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 477641006200 active site 477641006201 catalytic residues [active] 477641006202 CHAT domain; Region: CHAT; cl17868 477641006203 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 477641006204 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 477641006205 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 477641006206 Zn binding site [ion binding]; other site 477641006207 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 477641006208 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 477641006209 Peptidase family M28; Region: Peptidase_M28; pfam04389 477641006210 metal binding site [ion binding]; metal-binding site 477641006211 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 477641006212 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 477641006213 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 477641006214 active site 477641006215 substrate binding site [chemical binding]; other site 477641006216 Mg2+ binding site [ion binding]; other site 477641006217 alpha-dioxygenase; Region: PLN02283 477641006218 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 477641006219 putative heme binding site [chemical binding]; other site 477641006220 putative active site [active] 477641006221 putative substrate binding site [chemical binding]; other site 477641006222 amidophosphoribosyltransferase; Provisional; Region: PRK07272 477641006223 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 477641006224 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 477641006225 NAD(P) binding pocket [chemical binding]; other site 477641006226 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 477641006227 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 477641006228 Leishmanolysin; Region: Peptidase_M8; pfam01457 477641006229 active site 477641006230 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 477641006231 Kelch motif; Region: Kelch_6; pfam13964 477641006232 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 477641006233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641006234 Leishmanolysin; Region: Peptidase_M8; pfam01457 477641006235 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 477641006236 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 477641006237 active site 477641006238 catalytic triad [active] 477641006239 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 477641006240 Zn binding site [ion binding]; other site 477641006241 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641006242 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 477641006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641006244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006246 DNA binding residues [nucleotide binding] 477641006247 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 477641006248 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 477641006249 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641006250 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641006251 anti sigma factor interaction site; other site 477641006252 regulatory phosphorylation site [posttranslational modification]; other site 477641006253 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641006254 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641006255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641006256 ATP binding site [chemical binding]; other site 477641006257 Mg2+ binding site [ion binding]; other site 477641006258 G-X-G motif; other site 477641006259 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641006260 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 477641006261 putative NAD(P) binding site [chemical binding]; other site 477641006262 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 477641006263 GIY-YIG motif/motif A; other site 477641006264 putative active site [active] 477641006265 putative metal binding site [ion binding]; other site 477641006266 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 477641006267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641006269 active site 477641006270 phosphorylation site [posttranslational modification] 477641006271 intermolecular recognition site; other site 477641006272 dimerization interface [polypeptide binding]; other site 477641006273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006274 DNA binding residues [nucleotide binding] 477641006275 dimerization interface [polypeptide binding]; other site 477641006276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641006277 Histidine kinase; Region: HisKA_3; pfam07730 477641006278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641006279 ATP binding site [chemical binding]; other site 477641006280 Mg2+ binding site [ion binding]; other site 477641006281 G-X-G motif; other site 477641006282 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641006283 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641006284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 477641006285 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641006286 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641006287 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 477641006288 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 477641006289 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641006290 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 477641006291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641006292 active site 477641006293 DNA binding site [nucleotide binding] 477641006294 Int/Topo IB signature motif; other site 477641006295 hypothetical protein; Provisional; Region: PRK07906 477641006296 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 477641006297 putative metal binding site [ion binding]; other site 477641006298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641006299 NAD(P) binding site [chemical binding]; other site 477641006300 active site 477641006301 ANTAR domain; Region: ANTAR; pfam03861 477641006302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641006303 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 477641006304 NAD(P) binding site [chemical binding]; other site 477641006305 polysaccharide export protein Wza; Provisional; Region: PRK15078 477641006306 Uncharacterized conserved protein [Function unknown]; Region: COG3391 477641006307 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 477641006308 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 477641006309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 477641006310 RNA binding surface [nucleotide binding]; other site 477641006311 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 477641006312 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 477641006313 AAA domain; Region: AAA_30; pfam13604 477641006314 Family description; Region: UvrD_C_2; pfam13538 477641006315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641006316 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641006317 active site 477641006318 catalytic tetrad [active] 477641006319 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 477641006320 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641006321 catalytic core [active] 477641006322 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 477641006323 conserved hypothetical protein; Region: TIGR03843 477641006324 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 477641006325 active site 477641006326 argininosuccinate synthase; Validated; Region: PRK05370 477641006327 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641006328 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 477641006329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641006330 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 477641006331 active site 477641006332 HIGH motif; other site 477641006333 nucleotide binding site [chemical binding]; other site 477641006334 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641006335 active site 477641006336 KMSKS motif; other site 477641006337 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 477641006338 tRNA binding surface [nucleotide binding]; other site 477641006339 anticodon binding site; other site 477641006340 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 477641006341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 477641006342 Zn2+ binding site [ion binding]; other site 477641006343 Mg2+ binding site [ion binding]; other site 477641006344 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 477641006345 PAC2 family; Region: PAC2; pfam09754 477641006346 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 477641006347 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 477641006348 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 477641006349 substrate binding pocket [chemical binding]; other site 477641006350 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 477641006351 B12 binding site [chemical binding]; other site 477641006352 cobalt ligand [ion binding]; other site 477641006353 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 477641006354 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 477641006355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641006356 motif II; other site 477641006357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641006358 dimerization interface [polypeptide binding]; other site 477641006359 putative DNA binding site [nucleotide binding]; other site 477641006360 putative Zn2+ binding site [ion binding]; other site 477641006361 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 477641006362 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 477641006363 tetramer interface [polypeptide binding]; other site 477641006364 active site 477641006365 Mg2+/Mn2+ binding site [ion binding]; other site 477641006366 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 477641006367 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 477641006368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641006369 S-adenosylmethionine binding site [chemical binding]; other site 477641006370 proteasome ATPase; Region: pup_AAA; TIGR03689 477641006371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641006372 Walker A motif; other site 477641006373 ATP binding site [chemical binding]; other site 477641006374 Walker B motif; other site 477641006375 arginine finger; other site 477641006376 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 477641006377 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 477641006378 Pup-like protein; Region: Pup; pfam05639 477641006379 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 477641006380 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 477641006381 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 477641006382 active site 477641006383 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 477641006384 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 477641006385 active site 477641006386 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 477641006387 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 477641006388 Predicted transcriptional regulator [Transcription]; Region: COG2378 477641006389 WYL domain; Region: WYL; pfam13280 477641006390 Predicted transcriptional regulator [Transcription]; Region: COG2378 477641006391 WYL domain; Region: WYL; pfam13280 477641006392 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 477641006393 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 477641006394 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 477641006395 diacylglycerol kinase; Reviewed; Region: PRK11914 477641006396 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 477641006397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641006398 ATP binding site [chemical binding]; other site 477641006399 putative Mg++ binding site [ion binding]; other site 477641006400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641006401 ATP-binding site [chemical binding]; other site 477641006402 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 477641006403 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 477641006404 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 477641006405 active site 477641006406 metal binding site 1 [ion binding]; metal-binding site 477641006407 putative 5' ssDNA interaction site; other site 477641006408 metal binding site 3; metal-binding site 477641006409 metal binding site 2 [ion binding]; metal-binding site 477641006410 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 477641006411 putative DNA binding site [nucleotide binding]; other site 477641006412 putative metal binding site [ion binding]; other site 477641006413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 477641006414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 477641006415 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 477641006416 active site 477641006417 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 477641006418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641006419 putative DNA binding site [nucleotide binding]; other site 477641006420 putative Zn2+ binding site [ion binding]; other site 477641006421 AsnC family; Region: AsnC_trans_reg; pfam01037 477641006422 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 477641006423 protein-splicing catalytic site; other site 477641006424 thioester formation/cholesterol transfer; other site 477641006425 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 477641006426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641006427 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 477641006428 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641006429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 477641006430 putative acyl-acceptor binding pocket; other site 477641006431 Lipase maturation factor; Region: LMF1; pfam06762 477641006432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641006433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641006434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 477641006435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641006436 Amidohydrolase family; Region: Amidohydro_3; pfam07969 477641006437 active site 477641006438 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 477641006439 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 477641006440 B12 binding site [chemical binding]; other site 477641006441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 477641006442 active site 2 [active] 477641006443 active site 1 [active] 477641006444 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 477641006445 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 477641006446 putative active site [active] 477641006447 catalytic triad [active] 477641006448 putative dimer interface [polypeptide binding]; other site 477641006449 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 477641006450 Ligand binding site; other site 477641006451 Putative Catalytic site; other site 477641006452 DXD motif; other site 477641006453 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 477641006454 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 477641006455 thymidine kinase; Provisional; Region: PRK04296 477641006456 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 477641006457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641006458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 477641006459 putative acyl-acceptor binding pocket; other site 477641006460 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 477641006461 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 477641006462 putative active site [active] 477641006463 catalytic site [active] 477641006464 putative metal binding site [ion binding]; other site 477641006465 Isochorismatase family; Region: Isochorismatase; pfam00857 477641006466 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 477641006467 catalytic triad [active] 477641006468 conserved cis-peptide bond; other site 477641006469 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641006470 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 477641006471 putative active site [active] 477641006472 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 477641006473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641006474 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641006475 active site 477641006476 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 477641006477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641006478 Walker A/P-loop; other site 477641006479 ATP binding site [chemical binding]; other site 477641006480 Q-loop/lid; other site 477641006481 ABC transporter signature motif; other site 477641006482 Walker B; other site 477641006483 D-loop; other site 477641006484 H-loop/switch region; other site 477641006485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641006486 Histidine kinase; Region: HisKA_3; pfam07730 477641006487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641006489 active site 477641006490 phosphorylation site [posttranslational modification] 477641006491 intermolecular recognition site; other site 477641006492 dimerization interface [polypeptide binding]; other site 477641006493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006494 DNA binding residues [nucleotide binding] 477641006495 dimerization interface [polypeptide binding]; other site 477641006496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 477641006497 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 477641006498 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 477641006499 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 477641006500 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 477641006501 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 477641006502 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 477641006503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641006504 motif II; other site 477641006505 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 477641006506 substrate binding site [chemical binding]; other site 477641006507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641006508 Coenzyme A binding pocket [chemical binding]; other site 477641006509 pantothenate kinase; Provisional; Region: PRK05439 477641006510 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 477641006511 ATP-binding site [chemical binding]; other site 477641006512 CoA-binding site [chemical binding]; other site 477641006513 Mg2+-binding site [ion binding]; other site 477641006514 glycine dehydrogenase; Provisional; Region: PRK05367 477641006515 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641006516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641006517 catalytic residue [active] 477641006518 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 477641006519 tetramer interface [polypeptide binding]; other site 477641006520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641006521 catalytic residue [active] 477641006522 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 477641006523 DNA binding residues [nucleotide binding] 477641006524 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641006525 putative dimer interface [polypeptide binding]; other site 477641006526 Bifunctional nuclease; Region: DNase-RNase; pfam02577 477641006527 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 477641006528 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641006529 DNA binding residues [nucleotide binding] 477641006530 Double zinc ribbon; Region: DZR; pfam12773 477641006531 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 477641006532 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 477641006533 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 477641006534 phosphopeptide binding site; other site 477641006535 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 477641006536 lipoyl attachment site [posttranslational modification]; other site 477641006537 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 477641006538 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 477641006539 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 477641006540 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 477641006541 phosphoenolpyruvate synthase; Validated; Region: PRK06464 477641006542 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 477641006543 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 477641006544 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 477641006545 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 477641006546 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 477641006547 active site 477641006548 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 477641006549 putative ADP-binding pocket [chemical binding]; other site 477641006550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641006551 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 477641006552 Winged helix-turn helix; Region: HTH_29; pfam13551 477641006553 Integrase core domain; Region: rve; pfam00665 477641006554 Integrase core domain; Region: rve_3; pfam13683 477641006555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641006556 S-adenosylmethionine binding site [chemical binding]; other site 477641006557 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 477641006558 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 477641006559 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 477641006560 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 477641006561 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 477641006562 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 477641006563 putative trimer interface [polypeptide binding]; other site 477641006564 putative CoA binding site [chemical binding]; other site 477641006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 477641006566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641006567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641006568 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641006569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641006570 NAD(P) binding site [chemical binding]; other site 477641006571 active site 477641006572 Chain length determinant protein; Region: Wzz; cl15801 477641006573 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 477641006574 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641006575 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 477641006576 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 477641006577 NAD(P) binding site [chemical binding]; other site 477641006578 homodimer interface [polypeptide binding]; other site 477641006579 substrate binding site [chemical binding]; other site 477641006580 active site 477641006581 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 477641006582 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 477641006583 inhibitor-cofactor binding pocket; inhibition site 477641006584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641006585 catalytic residue [active] 477641006586 Bacterial sugar transferase; Region: Bac_transf; pfam02397 477641006587 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 477641006588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 477641006589 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 477641006590 putative active site [active] 477641006591 Right handed beta helix region; Region: Beta_helix; pfam13229 477641006592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 477641006593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641006594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641006595 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 477641006596 Domain of unknown function (DUF202); Region: DUF202; cl09954 477641006597 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 477641006598 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641006599 acyl-activating enzyme (AAE) consensus motif; other site 477641006600 AMP binding site [chemical binding]; other site 477641006601 active site 477641006602 CoA binding site [chemical binding]; other site 477641006603 MreB and similar proteins; Region: MreB_like; cd10225 477641006604 rod shape-determining protein MreB; Provisional; Region: PRK13930 477641006605 nucleotide binding site [chemical binding]; other site 477641006606 Mg binding site [ion binding]; other site 477641006607 putative protofilament interaction site [polypeptide binding]; other site 477641006608 RodZ interaction site [polypeptide binding]; other site 477641006609 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 477641006610 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 477641006611 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 477641006612 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 477641006613 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 477641006614 potential frameshift: common BLAST hit: gi|226363605|ref|YP_002781387.1| LuxR family transcriptional regulator 477641006615 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641006616 Walker A motif; other site 477641006617 ATP binding site [chemical binding]; other site 477641006618 Walker B motif; other site 477641006619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006621 DNA binding residues [nucleotide binding] 477641006622 dimerization interface [polypeptide binding]; other site 477641006623 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 477641006624 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 477641006625 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 477641006626 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 477641006627 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 477641006628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641006629 Walker A/P-loop; other site 477641006630 ATP binding site [chemical binding]; other site 477641006631 Q-loop/lid; other site 477641006632 ABC transporter signature motif; other site 477641006633 Walker B; other site 477641006634 D-loop; other site 477641006635 H-loop/switch region; other site 477641006636 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 477641006637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641006638 ABC-ATPase subunit interface; other site 477641006639 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 477641006640 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 477641006641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641006642 motif II; other site 477641006643 Predicted ATPase [General function prediction only]; Region: COG3903 477641006644 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 477641006645 cyclase homology domain; Region: CHD; cd07302 477641006646 nucleotidyl binding site; other site 477641006647 metal binding site [ion binding]; metal-binding site 477641006648 dimer interface [polypeptide binding]; other site 477641006649 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641006650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641006651 Cytochrome P450; Region: p450; cl12078 477641006652 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 477641006653 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 477641006654 FMN-binding pocket [chemical binding]; other site 477641006655 flavin binding motif; other site 477641006656 phosphate binding motif [ion binding]; other site 477641006657 beta-alpha-beta structure motif; other site 477641006658 NAD binding pocket [chemical binding]; other site 477641006659 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641006660 catalytic loop [active] 477641006661 iron binding site [ion binding]; other site 477641006662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641006663 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641006664 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641006665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641006666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641006667 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 477641006668 hypothetical protein; Provisional; Region: PRK07236 477641006669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641006670 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641006671 Cytochrome P450; Region: p450; cl12078 477641006672 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 477641006673 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 477641006674 FMN-binding pocket [chemical binding]; other site 477641006675 flavin binding motif; other site 477641006676 phosphate binding motif [ion binding]; other site 477641006677 beta-alpha-beta structure motif; other site 477641006678 NAD binding pocket [chemical binding]; other site 477641006679 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 477641006680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641006681 catalytic loop [active] 477641006682 iron binding site [ion binding]; other site 477641006683 galactokinase; Provisional; Region: PRK05101 477641006684 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641006685 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 477641006686 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 477641006687 active site 477641006688 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641006689 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641006690 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641006691 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641006692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 477641006693 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641006694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641006696 putative substrate translocation pore; other site 477641006697 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 477641006698 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 477641006699 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 477641006700 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 477641006701 pyranose oxidase; Region: pyranose_ox; TIGR02462 477641006702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 477641006703 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 477641006704 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 477641006705 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 477641006706 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641006707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641006708 Walker A/P-loop; other site 477641006709 ATP binding site [chemical binding]; other site 477641006710 Q-loop/lid; other site 477641006711 ABC transporter signature motif; other site 477641006712 Walker B; other site 477641006713 D-loop; other site 477641006714 H-loop/switch region; other site 477641006715 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 477641006716 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641006717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641006718 dimer interface [polypeptide binding]; other site 477641006719 conserved gate region; other site 477641006720 putative PBP binding loops; other site 477641006721 ABC-ATPase subunit interface; other site 477641006722 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641006723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641006724 Walker A/P-loop; other site 477641006725 ATP binding site [chemical binding]; other site 477641006726 Q-loop/lid; other site 477641006727 ABC transporter signature motif; other site 477641006728 Walker B; other site 477641006729 D-loop; other site 477641006730 H-loop/switch region; other site 477641006731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641006732 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641006733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641006734 dimer interface [polypeptide binding]; other site 477641006735 conserved gate region; other site 477641006736 putative PBP binding loops; other site 477641006737 ABC-ATPase subunit interface; other site 477641006738 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 477641006739 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 477641006740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641006741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641006742 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641006743 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641006744 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641006745 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641006746 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641006747 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 477641006748 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 477641006749 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641006750 hypothetical protein; Provisional; Region: PRK06847 477641006751 hypothetical protein; Provisional; Region: PRK07236 477641006752 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 477641006753 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641006754 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 477641006755 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641006756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641006757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641006758 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 477641006759 inhibitor binding site; inhibition site 477641006760 active site 477641006761 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 477641006762 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 477641006763 pyranose oxidase; Region: pyranose_ox; TIGR02462 477641006764 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 477641006765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641006766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641006767 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641006768 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 477641006769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641006770 Walker A/P-loop; other site 477641006771 ATP binding site [chemical binding]; other site 477641006772 Q-loop/lid; other site 477641006773 ABC transporter signature motif; other site 477641006774 Walker B; other site 477641006775 D-loop; other site 477641006776 H-loop/switch region; other site 477641006777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641006778 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641006779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641006780 dimer interface [polypeptide binding]; other site 477641006781 conserved gate region; other site 477641006782 putative PBP binding loops; other site 477641006783 ABC-ATPase subunit interface; other site 477641006784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641006785 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 477641006786 Walker A/P-loop; other site 477641006787 ATP binding site [chemical binding]; other site 477641006788 Q-loop/lid; other site 477641006789 ABC transporter signature motif; other site 477641006790 Walker B; other site 477641006791 D-loop; other site 477641006792 H-loop/switch region; other site 477641006793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641006794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641006795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641006796 dimer interface [polypeptide binding]; other site 477641006797 conserved gate region; other site 477641006798 putative PBP binding loops; other site 477641006799 ABC-ATPase subunit interface; other site 477641006800 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 477641006801 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641006802 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641006803 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 477641006804 nucleotide binding site [chemical binding]; other site 477641006805 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 477641006806 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641006807 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 477641006808 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 477641006809 DNA binding residues [nucleotide binding] 477641006810 dimer interface [polypeptide binding]; other site 477641006811 [2Fe-2S] cluster binding site [ion binding]; other site 477641006812 classical (c) SDRs; Region: SDR_c; cd05233 477641006813 NAD(P) binding site [chemical binding]; other site 477641006814 active site 477641006815 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 477641006816 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 477641006817 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 477641006818 YCII-related domain; Region: YCII; cl00999 477641006819 hypothetical protein; Provisional; Region: PRK07907 477641006820 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 477641006821 active site 477641006822 metal binding site [ion binding]; metal-binding site 477641006823 dimer interface [polypeptide binding]; other site 477641006824 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 477641006825 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 477641006826 putative dimer interface [polypeptide binding]; other site 477641006827 putative active site [active] 477641006828 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 477641006829 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 477641006830 CAAX protease self-immunity; Region: Abi; pfam02517 477641006831 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 477641006832 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 477641006833 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 477641006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641006836 putative substrate translocation pore; other site 477641006837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641006838 Short C-terminal domain; Region: SHOCT; pfam09851 477641006839 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 477641006840 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 477641006841 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 477641006842 Short C-terminal domain; Region: SHOCT; pfam09851 477641006843 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 477641006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 477641006845 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641006846 nudix motif; other site 477641006847 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 477641006848 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 477641006849 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 477641006850 Sulfatase; Region: Sulfatase; pfam00884 477641006851 Sulfatase; Region: Sulfatase; cl17466 477641006852 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 477641006853 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 477641006854 amphipathic channel; other site 477641006855 Asn-Pro-Ala signature motifs; other site 477641006856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006858 DNA binding residues [nucleotide binding] 477641006859 dimerization interface [polypeptide binding]; other site 477641006860 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 477641006861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006863 DNA binding residues [nucleotide binding] 477641006864 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641006865 nudix motif; other site 477641006866 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 477641006867 potential frameshift: common BLAST hit: gi|111020750|ref|YP_703722.1| diacylglycerol kinase, catalytic region 477641006868 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 477641006869 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641006870 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641006871 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641006872 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641006873 Uncharacterized conserved protein [Function unknown]; Region: COG1262 477641006874 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 477641006875 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 477641006876 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 477641006877 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 477641006878 Alkaline phosphatase homologues; Region: alkPPc; smart00098 477641006879 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 477641006880 active site 477641006881 dimer interface [polypeptide binding]; other site 477641006882 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 477641006883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641006884 Amidohydrolase; Region: Amidohydro_2; pfam04909 477641006885 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 477641006886 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 477641006887 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 477641006888 tetramer interface [polypeptide binding]; other site 477641006889 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 477641006890 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 477641006891 tetramer interface [polypeptide binding]; other site 477641006892 active site 477641006893 metal binding site [ion binding]; metal-binding site 477641006894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 477641006895 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 477641006896 Transcriptional regulators [Transcription]; Region: GntR; COG1802 477641006897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641006898 DNA-binding site [nucleotide binding]; DNA binding site 477641006899 FCD domain; Region: FCD; pfam07729 477641006900 classical (c) SDRs; Region: SDR_c; cd05233 477641006901 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 477641006902 NAD(P) binding site [chemical binding]; other site 477641006903 active site 477641006904 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641006905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641006906 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 477641006907 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641006908 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 477641006909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641006910 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641006911 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641006912 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641006913 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641006914 TM-ABC transporter signature motif; other site 477641006915 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641006916 TM-ABC transporter signature motif; other site 477641006917 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641006918 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 477641006919 Walker A/P-loop; other site 477641006920 ATP binding site [chemical binding]; other site 477641006921 Q-loop/lid; other site 477641006922 ABC transporter signature motif; other site 477641006923 Walker B; other site 477641006924 D-loop; other site 477641006925 H-loop/switch region; other site 477641006926 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641006927 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641006928 Walker A/P-loop; other site 477641006929 ATP binding site [chemical binding]; other site 477641006930 Q-loop/lid; other site 477641006931 ABC transporter signature motif; other site 477641006932 Walker B; other site 477641006933 D-loop; other site 477641006934 H-loop/switch region; other site 477641006935 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 477641006936 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641006937 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 477641006938 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641006939 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 477641006940 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 477641006941 active site 477641006942 metal binding site [ion binding]; metal-binding site 477641006943 Subunit A of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and similar enzymes; Region: PCA_45_Doxase_A_like; cd07921 477641006944 dimer interface [polypeptide binding]; other site 477641006945 tetramer interface [polypeptide binding]; other site 477641006946 active site 477641006947 Muconolactone delta-isomerase; Region: MIase; cl01992 477641006948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641006949 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 477641006950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641006951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641006952 active site 477641006953 phosphorylation site [posttranslational modification] 477641006954 intermolecular recognition site; other site 477641006955 dimerization interface [polypeptide binding]; other site 477641006956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641006957 DNA binding residues [nucleotide binding] 477641006958 dimerization interface [polypeptide binding]; other site 477641006959 PAS domain; Region: PAS; smart00091 477641006960 PAS domain; Region: PAS_9; pfam13426 477641006961 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641006962 Histidine kinase; Region: HisKA_3; pfam07730 477641006963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641006964 Mg2+ binding site [ion binding]; other site 477641006965 G-X-G motif; other site 477641006966 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 477641006967 FAD binding site [chemical binding]; other site 477641006968 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 477641006969 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 477641006970 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 477641006971 homodimer interface [polypeptide binding]; other site 477641006972 NADP binding site [chemical binding]; other site 477641006973 substrate binding site [chemical binding]; other site 477641006974 aminodeoxychorismate synthase; Provisional; Region: PRK07508 477641006975 chorismate binding enzyme; Region: Chorismate_bind; cl10555 477641006976 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 477641006977 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 477641006978 homodimer interface [polypeptide binding]; other site 477641006979 substrate-cofactor binding pocket; other site 477641006980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641006981 catalytic residue [active] 477641006982 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 477641006983 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 477641006984 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 477641006985 putative active site [active] 477641006986 putative substrate binding site [chemical binding]; other site 477641006987 putative cosubstrate binding site; other site 477641006988 catalytic site [active] 477641006989 Predicted acyl esterases [General function prediction only]; Region: COG2936 477641006990 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 477641006991 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 477641006992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 477641006993 NAD(P) binding site [chemical binding]; other site 477641006994 catalytic residues [active] 477641006995 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 477641006996 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 477641006997 catalytic Zn binding site [ion binding]; other site 477641006998 NAD binding site [chemical binding]; other site 477641006999 structural Zn binding site [ion binding]; other site 477641007000 potential frameshift: common BLAST hit: gi|26988671|ref|NP_744096.1| glycine cleavage system protein T 477641007001 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641007002 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 477641007003 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 477641007004 metal binding site [ion binding]; metal-binding site 477641007005 dimer interface [polypeptide binding]; other site 477641007006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641007007 Coenzyme A binding pocket [chemical binding]; other site 477641007008 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 477641007009 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 477641007010 active site 477641007011 octamer interface [polypeptide binding]; other site 477641007012 Helix-turn-helix domain; Region: HTH_19; pfam12844 477641007013 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 477641007014 Domain of unknown function (DUF955); Region: DUF955; pfam06114 477641007015 isocitrate lyase; Provisional; Region: PRK15063 477641007016 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 477641007017 tetramer interface [polypeptide binding]; other site 477641007018 active site 477641007019 Mg2+/Mn2+ binding site [ion binding]; other site 477641007020 malate synthase; Validated; Region: PRK09255 477641007021 malate synthase A; Region: malate_syn_A; TIGR01344 477641007022 active site 477641007023 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 477641007024 hypothetical protein; Provisional; Region: PRK06541 477641007025 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 477641007026 inhibitor-cofactor binding pocket; inhibition site 477641007027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641007028 catalytic residue [active] 477641007029 Predicted transcriptional regulator [Transcription]; Region: COG2378 477641007030 HTH domain; Region: HTH_11; pfam08279 477641007031 WYL domain; Region: WYL; pfam13280 477641007032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641007033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641007034 active site 477641007035 metal binding site [ion binding]; metal-binding site 477641007036 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 477641007037 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641007038 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007040 putative substrate translocation pore; other site 477641007041 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641007042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641007043 ATP binding site [chemical binding]; other site 477641007044 Mg2+ binding site [ion binding]; other site 477641007045 G-X-G motif; other site 477641007046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641007047 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641007048 active site 477641007049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641007050 MarR family; Region: MarR_2; cl17246 477641007051 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 477641007052 PAS domain; Region: PAS_9; pfam13426 477641007053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007054 putative active site [active] 477641007055 heme pocket [chemical binding]; other site 477641007056 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641007057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641007058 metal binding site [ion binding]; metal-binding site 477641007059 active site 477641007060 I-site; other site 477641007061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641007062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641007063 active site 477641007064 phosphorylation site [posttranslational modification] 477641007065 intermolecular recognition site; other site 477641007066 dimerization interface [polypeptide binding]; other site 477641007067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641007068 DNA binding residues [nucleotide binding] 477641007069 dimerization interface [polypeptide binding]; other site 477641007070 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641007071 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641007072 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641007073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007074 PAS domain; Region: PAS_9; pfam13426 477641007075 putative active site [active] 477641007076 heme pocket [chemical binding]; other site 477641007077 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641007078 GAF domain; Region: GAF; pfam01590 477641007079 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641007080 Uncharacterized conserved protein [Function unknown]; Region: COG2966 477641007081 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 477641007082 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 477641007083 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 477641007084 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 477641007085 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 477641007086 putative active site [active] 477641007087 putative substrate binding site [chemical binding]; other site 477641007088 putative cosubstrate binding site; other site 477641007089 catalytic site [active] 477641007090 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 477641007091 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 477641007092 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 477641007093 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 477641007094 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641007095 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 477641007096 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641007097 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 477641007098 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 477641007099 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 477641007100 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 477641007101 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 477641007102 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641007103 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 477641007104 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 477641007105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641007106 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641007107 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 477641007108 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 477641007109 [2Fe-2S] cluster binding site [ion binding]; other site 477641007110 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 477641007111 putative alpha subunit interface [polypeptide binding]; other site 477641007112 putative active site [active] 477641007113 putative substrate binding site [chemical binding]; other site 477641007114 Fe binding site [ion binding]; other site 477641007115 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641007116 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641007117 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641007118 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 477641007119 [2Fe-2S] cluster binding site [ion binding]; other site 477641007120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 477641007121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641007122 BCCT family transporter; Region: BCCT; pfam02028 477641007123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641007124 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641007125 active site 477641007126 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 477641007127 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641007128 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 477641007129 putative NAD(P) binding site [chemical binding]; other site 477641007130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641007131 salt bridge; other site 477641007132 non-specific DNA binding site [nucleotide binding]; other site 477641007133 sequence-specific DNA binding site [nucleotide binding]; other site 477641007134 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 477641007135 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641007136 classical (c) SDRs; Region: SDR_c; cd05233 477641007137 NAD(P) binding site [chemical binding]; other site 477641007138 active site 477641007139 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 477641007140 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 477641007141 ligand binding site [chemical binding]; other site 477641007142 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641007143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641007144 TM-ABC transporter signature motif; other site 477641007145 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641007146 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641007147 Walker A/P-loop; other site 477641007148 ATP binding site [chemical binding]; other site 477641007149 Q-loop/lid; other site 477641007150 ABC transporter signature motif; other site 477641007151 Walker B; other site 477641007152 D-loop; other site 477641007153 H-loop/switch region; other site 477641007154 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641007155 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641007156 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641007157 NAD(P) binding site [chemical binding]; other site 477641007158 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 477641007159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 477641007160 PYR/PP interface [polypeptide binding]; other site 477641007161 dimer interface [polypeptide binding]; other site 477641007162 TPP binding site [chemical binding]; other site 477641007163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 477641007164 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 477641007165 TPP-binding site [chemical binding]; other site 477641007166 dimer interface [polypeptide binding]; other site 477641007167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641007168 MarR family; Region: MarR_2; pfam12802 477641007169 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 477641007170 active site 477641007171 metal-binding site [ion binding] 477641007172 nucleotide-binding site [chemical binding]; other site 477641007173 YceI-like domain; Region: YceI; pfam04264 477641007174 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641007175 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641007176 Walker A/P-loop; other site 477641007177 ATP binding site [chemical binding]; other site 477641007178 Q-loop/lid; other site 477641007179 ABC transporter signature motif; other site 477641007180 Walker B; other site 477641007181 D-loop; other site 477641007182 H-loop/switch region; other site 477641007183 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641007184 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641007185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641007186 Walker A/P-loop; other site 477641007187 ATP binding site [chemical binding]; other site 477641007188 Q-loop/lid; other site 477641007189 ABC transporter signature motif; other site 477641007190 Walker B; other site 477641007191 D-loop; other site 477641007192 H-loop/switch region; other site 477641007193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641007194 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 477641007195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007196 dimer interface [polypeptide binding]; other site 477641007197 conserved gate region; other site 477641007198 putative PBP binding loops; other site 477641007199 ABC-ATPase subunit interface; other site 477641007200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641007201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007202 conserved gate region; other site 477641007203 putative PBP binding loops; other site 477641007204 ABC-ATPase subunit interface; other site 477641007205 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 477641007206 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 477641007207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641007208 active site 477641007209 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641007210 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641007211 NAD(P) binding site [chemical binding]; other site 477641007212 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 477641007213 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641007214 NAD binding site [chemical binding]; other site 477641007215 catalytic Zn binding site [ion binding]; other site 477641007216 substrate binding site [chemical binding]; other site 477641007217 structural Zn binding site [ion binding]; other site 477641007218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 477641007219 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 477641007220 NAD(P) binding site [chemical binding]; other site 477641007221 catalytic residues [active] 477641007222 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 477641007223 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641007224 NAD binding site [chemical binding]; other site 477641007225 catalytic Zn binding site [ion binding]; other site 477641007226 substrate binding site [chemical binding]; other site 477641007227 structural Zn binding site [ion binding]; other site 477641007228 Coenzyme A transferase; Region: CoA_trans; cl17247 477641007229 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 477641007230 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 477641007231 hypothetical protein; Provisional; Region: PRK06194 477641007232 classical (c) SDRs; Region: SDR_c; cd05233 477641007233 NAD(P) binding site [chemical binding]; other site 477641007234 active site 477641007235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641007236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007237 NAD(P) binding site [chemical binding]; other site 477641007238 active site 477641007239 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641007240 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641007241 NAD(P) binding site [chemical binding]; other site 477641007242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641007243 classical (c) SDRs; Region: SDR_c; cd05233 477641007244 NAD(P) binding site [chemical binding]; other site 477641007245 active site 477641007246 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641007247 classical (c) SDRs; Region: SDR_c; cd05233 477641007248 NAD(P) binding site [chemical binding]; other site 477641007249 active site 477641007250 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 477641007251 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641007252 NAD binding site [chemical binding]; other site 477641007253 catalytic Zn binding site [ion binding]; other site 477641007254 substrate binding site [chemical binding]; other site 477641007255 structural Zn binding site [ion binding]; other site 477641007256 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641007257 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641007258 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641007259 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 477641007260 putative active site [active] 477641007261 putative catalytic site [active] 477641007262 acyl-CoA synthetase; Validated; Region: PRK07798 477641007263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641007264 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641007265 acyl-activating enzyme (AAE) consensus motif; other site 477641007266 acyl-activating enzyme (AAE) consensus motif; other site 477641007267 AMP binding site [chemical binding]; other site 477641007268 active site 477641007269 CoA binding site [chemical binding]; other site 477641007270 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 477641007271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641007272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641007273 Dehydroquinase class II; Region: DHquinase_II; pfam01220 477641007274 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 477641007275 trimer interface [polypeptide binding]; other site 477641007276 active site 477641007277 dimer interface [polypeptide binding]; other site 477641007278 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 477641007279 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 477641007280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641007281 active site 477641007282 metal binding site [ion binding]; metal-binding site 477641007283 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 477641007284 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 477641007285 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 477641007286 shikimate binding site; other site 477641007287 NAD(P) binding site [chemical binding]; other site 477641007288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641007289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641007290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007291 metabolite-proton symporter; Region: 2A0106; TIGR00883 477641007292 putative substrate translocation pore; other site 477641007293 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 477641007294 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 477641007295 substrate binding pocket [chemical binding]; other site 477641007296 catalytic triad [active] 477641007297 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 477641007298 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641007299 putative NAD(P) binding site [chemical binding]; other site 477641007300 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641007301 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007303 putative substrate translocation pore; other site 477641007304 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641007305 CoenzymeA binding site [chemical binding]; other site 477641007306 subunit interaction site [polypeptide binding]; other site 477641007307 PHB binding site; other site 477641007308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641007309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641007310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641007311 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641007312 FAD binding domain; Region: FAD_binding_4; pfam01565 477641007313 phenol 2-monooxygenase; Provisional; Region: PRK08294 477641007314 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 477641007315 dimer interface [polypeptide binding]; other site 477641007316 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 477641007317 Sulfatase; Region: Sulfatase; pfam00884 477641007318 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 477641007319 putative active site; other site 477641007320 putative triphosphate binding site [ion binding]; other site 477641007321 putative metal binding residues [ion binding]; other site 477641007322 CHAD domain; Region: CHAD; pfam05235 477641007323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 477641007324 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641007325 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641007326 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641007327 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 477641007328 active site 477641007329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641007330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641007331 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 477641007332 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 477641007333 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641007334 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641007335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007336 dimer interface [polypeptide binding]; other site 477641007337 conserved gate region; other site 477641007338 putative PBP binding loops; other site 477641007339 ABC-ATPase subunit interface; other site 477641007340 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 477641007341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007342 dimer interface [polypeptide binding]; other site 477641007343 conserved gate region; other site 477641007344 putative PBP binding loops; other site 477641007345 ABC-ATPase subunit interface; other site 477641007346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641007347 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 477641007348 Walker A/P-loop; other site 477641007349 ATP binding site [chemical binding]; other site 477641007350 Q-loop/lid; other site 477641007351 ABC transporter signature motif; other site 477641007352 Walker B; other site 477641007353 D-loop; other site 477641007354 H-loop/switch region; other site 477641007355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641007356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 477641007357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641007358 Walker A/P-loop; other site 477641007359 ATP binding site [chemical binding]; other site 477641007360 Q-loop/lid; other site 477641007361 ABC transporter signature motif; other site 477641007362 Walker B; other site 477641007363 D-loop; other site 477641007364 H-loop/switch region; other site 477641007365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641007366 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641007367 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641007368 PA14 domain; Region: PA14; cl08459 477641007369 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641007370 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641007371 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 477641007372 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 477641007373 inhibitor binding site; inhibition site 477641007374 active site 477641007375 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 477641007376 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 477641007377 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 477641007378 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641007379 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 477641007380 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 477641007381 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 477641007382 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 477641007383 active site 477641007384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641007385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007386 NAD(P) binding site [chemical binding]; other site 477641007387 active site 477641007388 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641007389 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641007390 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641007391 phenol 2-monooxygenase; Provisional; Region: PRK08294 477641007392 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641007393 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 477641007394 dimer interface [polypeptide binding]; other site 477641007395 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 477641007396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641007397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641007398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641007399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007401 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641007402 Cytochrome P450; Region: p450; cl12078 477641007403 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 477641007404 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 477641007405 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 477641007406 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641007407 active site 477641007408 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 477641007409 FAD binding domain; Region: FAD_binding_3; pfam01494 477641007410 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641007411 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641007412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641007413 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 477641007414 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 477641007415 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 477641007416 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641007417 dimer interface [polypeptide binding]; other site 477641007418 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 477641007419 putative CheW interface [polypeptide binding]; other site 477641007420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641007421 MarR family; Region: MarR_2; pfam12802 477641007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007423 putative substrate translocation pore; other site 477641007424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007425 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 477641007426 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641007427 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 477641007428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641007429 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 477641007430 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 477641007431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 477641007432 Ligand Binding Site [chemical binding]; other site 477641007433 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641007434 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641007435 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641007436 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641007437 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 477641007438 Sulfatase; Region: Sulfatase; pfam00884 477641007439 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641007440 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641007441 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641007442 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641007443 Uncharacterized conserved protein [Function unknown]; Region: COG1262 477641007444 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 477641007445 Predicted flavoprotein [General function prediction only]; Region: COG0431 477641007446 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 477641007447 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 477641007448 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 477641007449 beta-D-glucuronidase; Provisional; Region: PRK10150 477641007450 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 477641007451 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 477641007452 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 477641007453 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 477641007454 Predicted membrane protein [Function unknown]; Region: COG2860 477641007455 UPF0126 domain; Region: UPF0126; pfam03458 477641007456 UPF0126 domain; Region: UPF0126; pfam03458 477641007457 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 477641007458 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 477641007459 metal binding site [ion binding]; metal-binding site 477641007460 putative dimer interface [polypeptide binding]; other site 477641007461 Protein of unknown function (DUF461); Region: DUF461; cl01071 477641007462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007463 NAD(P) binding site [chemical binding]; other site 477641007464 active site 477641007465 Predicted membrane protein [Function unknown]; Region: COG2323 477641007466 Pirin-related protein [General function prediction only]; Region: COG1741 477641007467 Pirin; Region: Pirin; pfam02678 477641007468 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 477641007469 Predicted flavoprotein [General function prediction only]; Region: COG0431 477641007470 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 477641007471 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 477641007472 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 477641007473 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 477641007474 Mechanosensitive ion channel; Region: MS_channel; pfam00924 477641007475 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 477641007476 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 477641007477 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 477641007478 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 477641007479 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 477641007480 putative active site [active] 477641007481 metal binding site [ion binding]; metal-binding site 477641007482 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 477641007483 putative active site [active] 477641007484 putative metal binding site [ion binding]; other site 477641007485 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641007486 Predicted membrane protein [Function unknown]; Region: COG2323 477641007487 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641007488 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641007489 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641007490 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641007491 glucuronate isomerase; Reviewed; Region: PRK02925 477641007492 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 477641007493 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 477641007494 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 477641007495 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 477641007496 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 477641007497 glucuronide transporter; Provisional; Region: PRK09848 477641007498 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 477641007499 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 477641007500 classical (c) SDRs; Region: SDR_c; cd05233 477641007501 NAD(P) binding site [chemical binding]; other site 477641007502 active site 477641007503 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 477641007504 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 477641007505 N- and C-terminal domain interface [polypeptide binding]; other site 477641007506 active site 477641007507 catalytic site [active] 477641007508 metal binding site [ion binding]; metal-binding site 477641007509 carbohydrate binding site [chemical binding]; other site 477641007510 ATP binding site [chemical binding]; other site 477641007511 Protein of unknown function (DUF461); Region: DUF461; cl01071 477641007512 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 477641007513 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 477641007514 putative active site [active] 477641007515 catalytic site [active] 477641007516 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 477641007517 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 477641007518 putative active site [active] 477641007519 catalytic site [active] 477641007520 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 477641007521 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 477641007522 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 477641007523 active site 477641007524 metal binding site [ion binding]; metal-binding site 477641007525 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 477641007526 conserved FAD binding motif [chemical binding]; other site 477641007527 Predicted membrane protein [Function unknown]; Region: COG2860 477641007528 UPF0126 domain; Region: UPF0126; pfam03458 477641007529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 477641007530 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 477641007531 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 477641007532 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 477641007533 active site 477641007534 catalytic site [active] 477641007535 Zn binding site [ion binding]; other site 477641007536 tetramer interface [polypeptide binding]; other site 477641007537 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 477641007538 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 477641007539 Na binding site [ion binding]; other site 477641007540 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 477641007541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641007542 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641007543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641007544 putative DNA binding site [nucleotide binding]; other site 477641007545 putative Zn2+ binding site [ion binding]; other site 477641007546 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641007547 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 477641007548 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 477641007549 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 477641007550 active site 477641007551 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 477641007552 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 477641007553 dimer interface [polypeptide binding]; other site 477641007554 active site 477641007555 glycine-pyridoxal phosphate binding site [chemical binding]; other site 477641007556 folate binding site [chemical binding]; other site 477641007557 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 477641007558 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641007559 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 477641007560 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 477641007561 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 477641007562 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641007563 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 477641007564 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 477641007565 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 477641007566 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 477641007567 pyruvate carboxylase subunit A; Validated; Region: PRK08654 477641007568 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641007569 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641007570 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 477641007571 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 477641007572 active site 477641007573 catalytic residues [active] 477641007574 metal binding site [ion binding]; metal-binding site 477641007575 homodimer binding site [polypeptide binding]; other site 477641007576 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641007577 carboxyltransferase (CT) interaction site; other site 477641007578 biotinylation site [posttranslational modification]; other site 477641007579 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 477641007580 substrate binding pocket [chemical binding]; other site 477641007581 dimer interface [polypeptide binding]; other site 477641007582 inhibitor binding site; inhibition site 477641007583 aminodeoxychorismate synthase; Provisional; Region: PRK07508 477641007584 chorismate binding enzyme; Region: Chorismate_bind; cl10555 477641007585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007586 PAS fold; Region: PAS_3; pfam08447 477641007587 putative active site [active] 477641007588 heme pocket [chemical binding]; other site 477641007589 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641007590 Peptidase family M48; Region: Peptidase_M48; cl12018 477641007591 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 477641007592 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 477641007593 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 477641007594 active site 477641007595 catalytic residues [active] 477641007596 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 477641007597 5' RNA guide strand anchoring site; other site 477641007598 active site 477641007599 SIR2-like domain; Region: SIR2_2; pfam13289 477641007600 TrwC relaxase; Region: TrwC; pfam08751 477641007601 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 477641007602 AAA domain; Region: AAA_30; pfam13604 477641007603 Family description; Region: UvrD_C_2; pfam13538 477641007604 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 477641007605 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 477641007606 active site 477641007607 metal binding site [ion binding]; metal-binding site 477641007608 interdomain interaction site; other site 477641007609 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 477641007610 Abi-like protein; Region: Abi_2; pfam07751 477641007611 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 477641007612 NlpC/P60 family; Region: NLPC_P60; cl17555 477641007613 AAA-like domain; Region: AAA_10; pfam12846 477641007614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641007615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641007616 active site 477641007617 catalytic tetrad [active] 477641007618 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641007619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007620 NAD(P) binding site [chemical binding]; other site 477641007621 active site 477641007622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007623 potential frameshift: common BLAST hit: gi|220912858|ref|YP_002488167.1| major facilitator superfamily protein 477641007624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641007626 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 477641007627 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 477641007628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007629 NAD(P) binding site [chemical binding]; other site 477641007630 active site 477641007631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641007632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641007633 active site 477641007634 catalytic tetrad [active] 477641007635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641007636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641007637 salt bridge; other site 477641007638 non-specific DNA binding site [nucleotide binding]; other site 477641007639 sequence-specific DNA binding site [nucleotide binding]; other site 477641007640 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641007641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641007642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007643 PAS fold; Region: PAS_3; pfam08447 477641007644 putative active site [active] 477641007645 heme pocket [chemical binding]; other site 477641007646 PAS fold; Region: PAS_4; pfam08448 477641007647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007648 putative active site [active] 477641007649 heme pocket [chemical binding]; other site 477641007650 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641007651 GAF domain; Region: GAF; cl17456 477641007652 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641007653 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641007654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641007655 ATP binding site [chemical binding]; other site 477641007656 Mg2+ binding site [ion binding]; other site 477641007657 G-X-G motif; other site 477641007658 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641007659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641007660 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process 477641007661 Homeodomain-like domain; Region: HTH_23; cl17451 477641007662 Winged helix-turn helix; Region: HTH_29; pfam13551 477641007663 Integrase core domain; Region: rve; pfam00665 477641007664 Integrase core domain; Region: rve_3; pfam13683 477641007665 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process 477641007666 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 477641007667 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641007668 Walker A motif; other site 477641007669 ATP binding site [chemical binding]; other site 477641007670 Walker B motif; other site 477641007671 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 477641007672 Helix-turn-helix domain; Region: HTH_17; pfam12728 477641007673 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 477641007674 Int/Topo IB signature motif; other site 477641007675 GTP-binding protein Der; Reviewed; Region: PRK03003 477641007676 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 477641007677 G1 box; other site 477641007678 GTP/Mg2+ binding site [chemical binding]; other site 477641007679 Switch I region; other site 477641007680 G2 box; other site 477641007681 Switch II region; other site 477641007682 G3 box; other site 477641007683 G4 box; other site 477641007684 G5 box; other site 477641007685 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 477641007686 G1 box; other site 477641007687 GTP/Mg2+ binding site [chemical binding]; other site 477641007688 Switch I region; other site 477641007689 G2 box; other site 477641007690 G3 box; other site 477641007691 Switch II region; other site 477641007692 G4 box; other site 477641007693 G5 box; other site 477641007694 cytidylate kinase; Provisional; Region: cmk; PRK00023 477641007695 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 477641007696 active site 477641007697 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 477641007698 CMP-binding site; other site 477641007699 The sites determining sugar specificity; other site 477641007700 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 477641007701 homotrimer interaction site [polypeptide binding]; other site 477641007702 active site 477641007703 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 477641007704 active site 477641007705 catalytic residues [active] 477641007706 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 477641007707 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 477641007708 Walker A/P-loop; other site 477641007709 ATP binding site [chemical binding]; other site 477641007710 Q-loop/lid; other site 477641007711 ABC transporter signature motif; other site 477641007712 Walker B; other site 477641007713 D-loop; other site 477641007714 H-loop/switch region; other site 477641007715 TOBE domain; Region: TOBE_2; pfam08402 477641007716 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641007717 D-xylulose kinase; Region: XylB; TIGR01312 477641007718 nucleotide binding site [chemical binding]; other site 477641007719 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 477641007720 xylose isomerase; Provisional; Region: PRK12677 477641007721 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641007722 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641007723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 477641007724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007725 dimer interface [polypeptide binding]; other site 477641007726 conserved gate region; other site 477641007727 putative PBP binding loops; other site 477641007728 ABC-ATPase subunit interface; other site 477641007729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641007730 dimer interface [polypeptide binding]; other site 477641007731 conserved gate region; other site 477641007732 putative PBP binding loops; other site 477641007733 ABC-ATPase subunit interface; other site 477641007734 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 477641007735 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 477641007736 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641007737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641007738 DNA binding site [nucleotide binding] 477641007739 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 477641007740 putative dimerization interface [polypeptide binding]; other site 477641007741 putative ligand binding site [chemical binding]; other site 477641007742 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641007743 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641007744 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641007745 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641007746 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 477641007747 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 477641007748 RNA binding surface [nucleotide binding]; other site 477641007749 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 477641007750 active site 477641007751 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 477641007752 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 477641007753 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 477641007754 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641007755 P-loop; other site 477641007756 Magnesium ion binding site [ion binding]; other site 477641007757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641007758 Magnesium ion binding site [ion binding]; other site 477641007759 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 477641007760 active site 477641007761 metal binding site [ion binding]; metal-binding site 477641007762 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 477641007763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641007764 active site 477641007765 DNA binding site [nucleotide binding] 477641007766 Int/Topo IB signature motif; other site 477641007767 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 477641007768 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 477641007769 hexamer interface [polypeptide binding]; other site 477641007770 ligand binding site [chemical binding]; other site 477641007771 putative active site [active] 477641007772 NAD(P) binding site [chemical binding]; other site 477641007773 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641007774 RibD C-terminal domain; Region: RibD_C; cl17279 477641007775 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641007776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641007777 DinB superfamily; Region: DinB_2; pfam12867 477641007778 Domain of unknown function (DUF336); Region: DUF336; pfam03928 477641007779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641007780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641007781 active site 477641007782 ATP binding site [chemical binding]; other site 477641007783 substrate binding site [chemical binding]; other site 477641007784 activation loop (A-loop); other site 477641007785 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 477641007786 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 477641007787 dimer interface [polypeptide binding]; other site 477641007788 active site 477641007789 ADP-ribose binding site [chemical binding]; other site 477641007790 nudix motif; other site 477641007791 metal binding site [ion binding]; metal-binding site 477641007792 CTP synthetase; Validated; Region: pyrG; PRK05380 477641007793 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 477641007794 Catalytic site [active] 477641007795 active site 477641007796 UTP binding site [chemical binding]; other site 477641007797 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 477641007798 active site 477641007799 putative oxyanion hole; other site 477641007800 catalytic triad [active] 477641007801 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641007802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641007803 Evidence 2b : Function of strongly homologous gene; Product type s : structure 477641007804 Evidence 2b : Function of strongly homologous gene; Product type s : structure 477641007805 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 477641007806 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 477641007807 Thiamine pyrophosphokinase; Region: TPK; cl08415 477641007808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641007809 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 477641007810 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 477641007811 putative di-iron ligands [ion binding]; other site 477641007812 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 477641007813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 477641007814 FAD binding pocket [chemical binding]; other site 477641007815 FAD binding motif [chemical binding]; other site 477641007816 phosphate binding motif [ion binding]; other site 477641007817 beta-alpha-beta structure motif; other site 477641007818 NAD binding pocket [chemical binding]; other site 477641007819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641007820 catalytic loop [active] 477641007821 iron binding site [ion binding]; other site 477641007822 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641007823 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 477641007824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641007825 Walker A/P-loop; other site 477641007826 ATP binding site [chemical binding]; other site 477641007827 Q-loop/lid; other site 477641007828 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 477641007829 ABC transporter signature motif; other site 477641007830 Walker B; other site 477641007831 D-loop; other site 477641007832 H-loop/switch region; other site 477641007833 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 477641007834 ATP-NAD kinase; Region: NAD_kinase; pfam01513 477641007835 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 477641007836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 477641007837 RNA binding surface [nucleotide binding]; other site 477641007838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641007839 S-adenosylmethionine binding site [chemical binding]; other site 477641007840 SCP-2 sterol transfer family; Region: SCP2; pfam02036 477641007841 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 477641007842 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 477641007843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641007844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 477641007845 binding surface 477641007846 TPR motif; other site 477641007847 TPR repeat; Region: TPR_11; pfam13414 477641007848 Uncharacterized conserved protein [Function unknown]; Region: COG4198 477641007849 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 477641007850 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 477641007851 generic binding surface II; other site 477641007852 generic binding surface I; other site 477641007853 potential protein location (protein of unknown function [Modestobacter marinus]) that overlaps RNA (ribosomal RNA 16S ribosomal RNA) 477641007854 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 477641007855 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 477641007856 active site 477641007857 HIGH motif; other site 477641007858 dimer interface [polypeptide binding]; other site 477641007859 KMSKS motif; other site 477641007860 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 477641007861 active site 477641007862 DNA binding site [nucleotide binding] 477641007863 argininosuccinate lyase; Provisional; Region: PRK00855 477641007864 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 477641007865 active sites [active] 477641007866 tetramer interface [polypeptide binding]; other site 477641007867 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 477641007868 arginine repressor; Provisional; Region: PRK04280 477641007869 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 477641007870 ornithine carbamoyltransferase; Provisional; Region: PRK00779 477641007871 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 477641007872 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 477641007873 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 477641007874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 477641007875 inhibitor-cofactor binding pocket; inhibition site 477641007876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641007877 catalytic residue [active] 477641007878 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 477641007879 feedback inhibition sensing region; other site 477641007880 homohexameric interface [polypeptide binding]; other site 477641007881 nucleotide binding site [chemical binding]; other site 477641007882 N-acetyl-L-glutamate binding site [chemical binding]; other site 477641007883 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 477641007884 heterotetramer interface [polypeptide binding]; other site 477641007885 active site pocket [active] 477641007886 cleavage site 477641007887 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 477641007888 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 477641007889 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 477641007890 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 477641007891 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641007892 anti sigma factor interaction site; other site 477641007893 regulatory phosphorylation site [posttranslational modification]; other site 477641007894 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641007895 classical (c) SDRs; Region: SDR_c; cd05233 477641007896 NAD(P) binding site [chemical binding]; other site 477641007897 active site 477641007898 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 477641007899 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 477641007900 putative tRNA-binding site [nucleotide binding]; other site 477641007901 B3/4 domain; Region: B3_4; pfam03483 477641007902 tRNA synthetase B5 domain; Region: B5; smart00874 477641007903 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 477641007904 dimer interface [polypeptide binding]; other site 477641007905 motif 1; other site 477641007906 motif 3; other site 477641007907 motif 2; other site 477641007908 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 477641007909 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 477641007910 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 477641007911 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 477641007912 dimer interface [polypeptide binding]; other site 477641007913 motif 1; other site 477641007914 active site 477641007915 motif 2; other site 477641007916 motif 3; other site 477641007917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641007918 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 477641007919 PAS domain; Region: PAS_9; pfam13426 477641007920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641007921 putative active site [active] 477641007922 heme pocket [chemical binding]; other site 477641007923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641007924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641007925 metal binding site [ion binding]; metal-binding site 477641007926 active site 477641007927 I-site; other site 477641007928 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 477641007929 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 477641007930 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 477641007931 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 477641007932 23S rRNA binding site [nucleotide binding]; other site 477641007933 L21 binding site [polypeptide binding]; other site 477641007934 L13 binding site [polypeptide binding]; other site 477641007935 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 477641007936 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 477641007937 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 477641007938 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 477641007939 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 477641007940 hypothetical protein; Provisional; Region: PRK06547 477641007941 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 477641007942 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 477641007943 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 477641007944 active site 477641007945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641007946 DNA binding site [nucleotide binding] 477641007947 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 477641007948 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 477641007949 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 477641007950 Helix-turn-helix domain; Region: HTH_18; pfam12833 477641007951 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 477641007952 Evidence 2b : Function of strongly homologous gene 477641007953 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 477641007954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641007955 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 477641007956 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 477641007957 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 477641007958 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 477641007959 [4Fe-4S] binding site [ion binding]; other site 477641007960 molybdopterin cofactor binding site; other site 477641007961 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 477641007962 molybdopterin cofactor binding site; other site 477641007963 Protein of unknown function (DUF419); Region: DUF419; cl15265 477641007964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 477641007965 dimer interface [polypeptide binding]; other site 477641007966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641007967 metal binding site [ion binding]; metal-binding site 477641007968 hypothetical protein; Provisional; Region: PRK09256 477641007969 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 477641007970 putative hydrophobic ligand binding site [chemical binding]; other site 477641007971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641007972 catalytic core [active] 477641007973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641007974 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 477641007975 dimer interface [polypeptide binding]; other site 477641007976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641007977 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 477641007978 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 477641007979 Haemolytic domain; Region: Haemolytic; pfam01809 477641007980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641007981 short chain dehydrogenase; Provisional; Region: PRK06701 477641007982 NAD(P) binding site [chemical binding]; other site 477641007983 active site 477641007984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641007985 ATP binding site [chemical binding]; other site 477641007986 putative Mg++ binding site [ion binding]; other site 477641007987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641007988 nucleotide binding region [chemical binding]; other site 477641007989 ATP-binding site [chemical binding]; other site 477641007990 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 477641007991 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641007992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641007993 metal binding site [ion binding]; metal-binding site 477641007994 active site 477641007995 I-site; other site 477641007996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641007997 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641007998 hypothetical protein; Provisional; Region: PRK10621 477641007999 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 477641008000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641008001 dimerization interface [polypeptide binding]; other site 477641008002 putative DNA binding site [nucleotide binding]; other site 477641008003 putative Zn2+ binding site [ion binding]; other site 477641008004 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 477641008005 putative hydrophobic ligand binding site [chemical binding]; other site 477641008006 trehalose synthase; Region: treS_nterm; TIGR02456 477641008007 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 477641008008 active site 477641008009 catalytic site [active] 477641008010 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 477641008011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641008012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641008013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641008014 non-specific DNA binding site [nucleotide binding]; other site 477641008015 salt bridge; other site 477641008016 sequence-specific DNA binding site [nucleotide binding]; other site 477641008017 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 477641008018 RibD C-terminal domain; Region: RibD_C; cl17279 477641008019 CAAX protease self-immunity; Region: Abi; pfam02517 477641008020 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 477641008021 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 477641008022 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641008023 Epoxide hydrolase N terminus; Region: EHN; pfam06441 477641008024 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 477641008025 elongation factor G; Reviewed; Region: PRK12740 477641008026 G1 box; other site 477641008027 GTP/Mg2+ binding site [chemical binding]; other site 477641008028 G2 box; other site 477641008029 Switch I region; other site 477641008030 G3 box; other site 477641008031 Switch II region; other site 477641008032 G4 box; other site 477641008033 G5 box; other site 477641008034 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 477641008035 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 477641008036 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 477641008037 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 477641008038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641008039 nucleotide binding region [chemical binding]; other site 477641008040 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 477641008041 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 477641008042 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 477641008043 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 477641008044 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641008045 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641008046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641008047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641008048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641008049 putative substrate translocation pore; other site 477641008050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641008051 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 477641008052 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 477641008053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641008054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 477641008055 Low molecular weight phosphatase family; Region: LMWPc; cl00105 477641008056 cytosine deaminase; Provisional; Region: PRK05985 477641008057 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 477641008058 active site 477641008059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 477641008060 EamA-like transporter family; Region: EamA; pfam00892 477641008061 EamA-like transporter family; Region: EamA; pfam00892 477641008062 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 477641008063 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 477641008064 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 477641008065 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641008066 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 477641008067 Subtilisin inhibitor-like; Region: SSI; cl11594 477641008068 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 477641008069 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 477641008070 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 477641008071 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 477641008072 metal binding site [ion binding]; metal-binding site 477641008073 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 477641008074 homopentamer interface [polypeptide binding]; other site 477641008075 active site 477641008076 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 477641008077 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 477641008078 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 477641008079 dimerization interface [polypeptide binding]; other site 477641008080 active site 477641008081 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 477641008082 Lumazine binding domain; Region: Lum_binding; pfam00677 477641008083 Lumazine binding domain; Region: Lum_binding; pfam00677 477641008084 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 477641008085 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 477641008086 catalytic motif [active] 477641008087 Zn binding site [ion binding]; other site 477641008088 RibD C-terminal domain; Region: RibD_C; pfam01872 477641008089 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 477641008090 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 477641008091 substrate binding site [chemical binding]; other site 477641008092 hexamer interface [polypeptide binding]; other site 477641008093 metal binding site [ion binding]; metal-binding site 477641008094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641008095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641008096 active site 477641008097 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 477641008098 putative RNA binding site [nucleotide binding]; other site 477641008099 potential frameshift: common BLAST hit: gi|284991542|ref|YP_003410096.1| Fmu (Sun) domain-containing protein 477641008100 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 477641008101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641008102 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 477641008103 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 477641008104 substrate binding site [chemical binding]; other site 477641008105 putative active site [active] 477641008106 putative cosubstrate binding site; other site 477641008107 catalytic site [active] 477641008108 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 477641008109 substrate binding site [chemical binding]; other site 477641008110 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 477641008111 active site 477641008112 catalytic residues [active] 477641008113 metal binding site [ion binding]; metal-binding site 477641008114 primosome assembly protein PriA; Provisional; Region: PRK14873 477641008115 S-adenosylmethionine synthetase; Validated; Region: PRK05250 477641008116 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 477641008117 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 477641008118 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 477641008119 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 477641008120 Flavoprotein; Region: Flavoprotein; pfam02441 477641008121 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 477641008122 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 477641008123 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 477641008124 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 477641008125 catalytic site [active] 477641008126 G-X2-G-X-G-K; other site 477641008127 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 477641008128 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 477641008129 active site 477641008130 dimer interface [polypeptide binding]; other site 477641008131 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 477641008132 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 477641008133 heterodimer interface [polypeptide binding]; other site 477641008134 active site 477641008135 FMN binding site [chemical binding]; other site 477641008136 homodimer interface [polypeptide binding]; other site 477641008137 substrate binding site [chemical binding]; other site 477641008138 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 477641008139 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 477641008140 FAD binding pocket [chemical binding]; other site 477641008141 FAD binding motif [chemical binding]; other site 477641008142 phosphate binding motif [ion binding]; other site 477641008143 beta-alpha-beta structure motif; other site 477641008144 NAD binding pocket [chemical binding]; other site 477641008145 Iron coordination center [ion binding]; other site 477641008146 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 477641008147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641008148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641008149 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 477641008150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641008151 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641008152 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 477641008153 IMP binding site; other site 477641008154 dimer interface [polypeptide binding]; other site 477641008155 interdomain contacts; other site 477641008156 partial ornithine binding site; other site 477641008157 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 477641008158 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 477641008159 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 477641008160 catalytic site [active] 477641008161 subunit interface [polypeptide binding]; other site 477641008162 dihydroorotase; Validated; Region: pyrC; PRK09357 477641008163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641008164 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 477641008165 active site 477641008166 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 477641008167 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 477641008168 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 477641008169 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 477641008170 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 477641008171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641008172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641008173 non-specific DNA binding site [nucleotide binding]; other site 477641008174 salt bridge; other site 477641008175 sequence-specific DNA binding site [nucleotide binding]; other site 477641008176 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 477641008177 putative RNA binding site [nucleotide binding]; other site 477641008178 elongation factor P; Validated; Region: PRK00529 477641008179 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 477641008180 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 477641008181 RNA binding site [nucleotide binding]; other site 477641008182 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 477641008183 RNA binding site [nucleotide binding]; other site 477641008184 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 477641008185 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 477641008186 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 477641008187 active site 477641008188 Dehydroquinase class II; Region: DHquinase_II; pfam01220 477641008189 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 477641008190 trimer interface [polypeptide binding]; other site 477641008191 active site 477641008192 dimer interface [polypeptide binding]; other site 477641008193 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 477641008194 active site 477641008195 dimer interface [polypeptide binding]; other site 477641008196 metal binding site [ion binding]; metal-binding site 477641008197 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 477641008198 Shikimate kinase; Region: SKI; pfam01202 477641008199 ADP binding site [chemical binding]; other site 477641008200 magnesium binding site [ion binding]; other site 477641008201 putative shikimate binding site; other site 477641008202 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 477641008203 chorismate synthase; Validated; Region: PRK05382 477641008204 Tetramer interface [polypeptide binding]; other site 477641008205 active site 477641008206 FMN-binding site [chemical binding]; other site 477641008207 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 477641008208 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 477641008209 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 477641008210 shikimate binding site; other site 477641008211 NAD(P) binding site [chemical binding]; other site 477641008212 YceG-like family; Region: YceG; pfam02618 477641008213 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 477641008214 dimerization interface [polypeptide binding]; other site 477641008215 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 477641008216 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 477641008217 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 477641008218 motif 1; other site 477641008219 active site 477641008220 motif 2; other site 477641008221 motif 3; other site 477641008222 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 477641008223 DHHA1 domain; Region: DHHA1; pfam02272 477641008224 recombination factor protein RarA; Reviewed; Region: PRK13342 477641008225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641008226 Walker A motif; other site 477641008227 ATP binding site [chemical binding]; other site 477641008228 Walker B motif; other site 477641008229 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 477641008230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641008231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641008232 active site 477641008233 catalytic tetrad [active] 477641008234 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641008235 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 477641008236 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 477641008237 dimer interface [polypeptide binding]; other site 477641008238 anticodon binding site; other site 477641008239 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 477641008240 homodimer interface [polypeptide binding]; other site 477641008241 motif 1; other site 477641008242 active site 477641008243 motif 2; other site 477641008244 GAD domain; Region: GAD; pfam02938 477641008245 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 477641008246 active site 477641008247 motif 3; other site 477641008248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641008249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641008250 active site 477641008251 catalytic tetrad [active] 477641008252 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 477641008253 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 477641008254 dimer interface [polypeptide binding]; other site 477641008255 motif 1; other site 477641008256 active site 477641008257 motif 2; other site 477641008258 motif 3; other site 477641008259 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 477641008260 anticodon binding site; other site 477641008261 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 477641008262 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 477641008263 active site 477641008264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641008265 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 477641008266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 477641008267 Zn2+ binding site [ion binding]; other site 477641008268 Mg2+ binding site [ion binding]; other site 477641008269 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 477641008270 synthetase active site [active] 477641008271 NTP binding site [chemical binding]; other site 477641008272 metal binding site [ion binding]; metal-binding site 477641008273 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 477641008274 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 477641008275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641008276 active site 477641008277 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 477641008278 Protein export membrane protein; Region: SecD_SecF; cl14618 477641008279 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 477641008280 Protein export membrane protein; Region: SecD_SecF; cl14618 477641008281 Preprotein translocase subunit; Region: YajC; pfam02699 477641008282 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 477641008283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641008284 Walker A motif; other site 477641008285 ATP binding site [chemical binding]; other site 477641008286 Walker B motif; other site 477641008287 arginine finger; other site 477641008288 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 477641008289 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 477641008290 RuvA N terminal domain; Region: RuvA_N; pfam01330 477641008291 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 477641008292 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 477641008293 active site 477641008294 putative DNA-binding cleft [nucleotide binding]; other site 477641008295 dimer interface [polypeptide binding]; other site 477641008296 hypothetical protein; Validated; Region: PRK00110 477641008297 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 477641008298 predicted active site [active] 477641008299 catalytic triad [active] 477641008300 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 477641008301 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 477641008302 active site 477641008303 multimer interface [polypeptide binding]; other site 477641008304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641008305 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641008306 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 477641008307 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 477641008308 putative acyl-acceptor binding pocket; other site 477641008309 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 477641008310 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 477641008311 nucleotide binding site/active site [active] 477641008312 HIT family signature motif; other site 477641008313 catalytic residue [active] 477641008314 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 477641008315 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 477641008316 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 477641008317 active site 477641008318 dimer interface [polypeptide binding]; other site 477641008319 motif 1; other site 477641008320 motif 2; other site 477641008321 motif 3; other site 477641008322 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 477641008323 anticodon binding site; other site 477641008324 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 477641008325 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 477641008326 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 477641008327 HNH endonuclease; Region: HNH; pfam01844 477641008328 active site 477641008329 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 477641008330 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 477641008331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641008332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641008333 DNA binding residues [nucleotide binding] 477641008334 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 477641008335 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 477641008336 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 477641008337 dimer interface [polypeptide binding]; other site 477641008338 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 477641008339 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 477641008340 CoA-binding site [chemical binding]; other site 477641008341 ATP-binding [chemical binding]; other site 477641008342 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 477641008343 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 477641008344 RNA binding site [nucleotide binding]; other site 477641008345 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 477641008346 RNA binding site [nucleotide binding]; other site 477641008347 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 477641008348 RNA binding site [nucleotide binding]; other site 477641008349 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 477641008350 RNA binding site [nucleotide binding]; other site 477641008351 potential frameshift: common BLAST hit: gi|284991622|ref|YP_003410176.1| type 11 methyltransferase 477641008352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641008353 S-adenosylmethionine binding site [chemical binding]; other site 477641008354 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 477641008355 dimer interface [polypeptide binding]; other site 477641008356 tetramer interface [polypeptide binding]; other site 477641008357 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 477641008358 metal binding site [ion binding]; metal-binding site 477641008359 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 477641008360 active site 477641008361 citrylCoA binding site [chemical binding]; other site 477641008362 oxalacetate binding site [chemical binding]; other site 477641008363 coenzyme A binding site [chemical binding]; other site 477641008364 catalytic triad [active] 477641008365 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 477641008366 CoA-transferase family III; Region: CoA_transf_3; pfam02515 477641008367 hypothetical protein; Provisional; Region: PRK08204 477641008368 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641008369 active site 477641008370 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 477641008371 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641008372 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641008373 DNA polymerase I; Provisional; Region: PRK05755 477641008374 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 477641008375 active site 477641008376 metal binding site 1 [ion binding]; metal-binding site 477641008377 putative 5' ssDNA interaction site; other site 477641008378 metal binding site 3; metal-binding site 477641008379 metal binding site 2 [ion binding]; metal-binding site 477641008380 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 477641008381 putative DNA binding site [nucleotide binding]; other site 477641008382 putative metal binding site [ion binding]; other site 477641008383 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 477641008384 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 477641008385 active site 477641008386 DNA binding site [nucleotide binding] 477641008387 catalytic site [active] 477641008388 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641008389 CoenzymeA binding site [chemical binding]; other site 477641008390 subunit interaction site [polypeptide binding]; other site 477641008391 PHB binding site; other site 477641008392 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 477641008393 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641008394 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641008395 TM-ABC transporter signature motif; other site 477641008396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641008397 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641008398 TM-ABC transporter signature motif; other site 477641008399 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641008400 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641008401 Walker A/P-loop; other site 477641008402 ATP binding site [chemical binding]; other site 477641008403 Q-loop/lid; other site 477641008404 ABC transporter signature motif; other site 477641008405 Walker B; other site 477641008406 D-loop; other site 477641008407 H-loop/switch region; other site 477641008408 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641008409 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 477641008410 Walker A/P-loop; other site 477641008411 ATP binding site [chemical binding]; other site 477641008412 Q-loop/lid; other site 477641008413 ABC transporter signature motif; other site 477641008414 Walker B; other site 477641008415 D-loop; other site 477641008416 H-loop/switch region; other site 477641008417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641008418 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 477641008419 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641008420 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 477641008421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641008422 active site 477641008423 phosphorylation site [posttranslational modification] 477641008424 intermolecular recognition site; other site 477641008425 dimerization interface [polypeptide binding]; other site 477641008426 ANTAR domain; Region: ANTAR; pfam03861 477641008427 tyrosine decarboxylase; Region: PLN02880 477641008428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641008429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641008430 catalytic residue [active] 477641008431 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 477641008432 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 477641008433 active site 477641008434 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 477641008435 catalytic triad [active] 477641008436 dimer interface [polypeptide binding]; other site 477641008437 pyruvate kinase; Provisional; Region: PRK06247 477641008438 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 477641008439 domain interfaces; other site 477641008440 active site 477641008441 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 477641008442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641008443 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 477641008444 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 477641008445 active site 477641008446 dimer interface [polypeptide binding]; other site 477641008447 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 477641008448 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 477641008449 active site 477641008450 FMN binding site [chemical binding]; other site 477641008451 substrate binding site [chemical binding]; other site 477641008452 3Fe-4S cluster binding site [ion binding]; other site 477641008453 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 477641008454 domain interface; other site 477641008455 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 477641008456 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 477641008457 substrate binding site [chemical binding]; other site 477641008458 active site 477641008459 catalytic residues [active] 477641008460 heterodimer interface [polypeptide binding]; other site 477641008461 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 477641008462 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 477641008463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641008464 catalytic residue [active] 477641008465 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 477641008466 active site 477641008467 ribulose/triose binding site [chemical binding]; other site 477641008468 phosphate binding site [ion binding]; other site 477641008469 substrate (anthranilate) binding pocket [chemical binding]; other site 477641008470 product (indole) binding pocket [chemical binding]; other site 477641008471 anthranilate synthase component I; Provisional; Region: PRK13571 477641008472 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 477641008473 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 477641008474 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 477641008475 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 477641008476 FAD binding domain; Region: FAD_binding_2; pfam00890 477641008477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641008478 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 477641008479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008480 Walker A/P-loop; other site 477641008481 ATP binding site [chemical binding]; other site 477641008482 Q-loop/lid; other site 477641008483 ABC transporter signature motif; other site 477641008484 Walker B; other site 477641008485 D-loop; other site 477641008486 H-loop/switch region; other site 477641008487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641008488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641008489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008490 Walker A/P-loop; other site 477641008491 ATP binding site [chemical binding]; other site 477641008492 Q-loop/lid; other site 477641008493 ABC transporter signature motif; other site 477641008494 Walker B; other site 477641008495 D-loop; other site 477641008496 H-loop/switch region; other site 477641008497 TIGR03085 family protein; Region: TIGR03085 477641008498 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 477641008499 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641008500 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641008501 active site 477641008502 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 477641008503 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 477641008504 substrate binding site [chemical binding]; other site 477641008505 glutamase interaction surface [polypeptide binding]; other site 477641008506 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 477641008507 homotrimer interaction site [polypeptide binding]; other site 477641008508 putative active site [active] 477641008509 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 477641008510 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 477641008511 catalytic residues [active] 477641008512 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 477641008513 putative FMN binding site [chemical binding]; other site 477641008514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641008515 classical (c) SDRs; Region: SDR_c; cd05233 477641008516 NAD(P) binding site [chemical binding]; other site 477641008517 active site 477641008518 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 477641008519 Peptidase family M28; Region: Peptidase_M28; pfam04389 477641008520 metal binding site [ion binding]; metal-binding site 477641008521 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 477641008522 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 477641008523 putative active site [active] 477641008524 oxyanion strand; other site 477641008525 catalytic triad [active] 477641008526 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641008527 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641008528 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641008529 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641008530 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641008531 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641008532 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 477641008533 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 477641008534 DNA binding residues [nucleotide binding] 477641008535 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 477641008536 putative active site pocket [active] 477641008537 4-fold oligomerization interface [polypeptide binding]; other site 477641008538 metal binding residues [ion binding]; metal-binding site 477641008539 3-fold/trimer interface [polypeptide binding]; other site 477641008540 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 477641008541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641008542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641008543 homodimer interface [polypeptide binding]; other site 477641008544 catalytic residue [active] 477641008545 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 477641008546 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 477641008547 NAD binding site [chemical binding]; other site 477641008548 dimerization interface [polypeptide binding]; other site 477641008549 product binding site; other site 477641008550 substrate binding site [chemical binding]; other site 477641008551 zinc binding site [ion binding]; other site 477641008552 catalytic residues [active] 477641008553 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 477641008554 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 477641008555 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 477641008556 active site 477641008557 PHP Thumb interface [polypeptide binding]; other site 477641008558 metal binding site [ion binding]; metal-binding site 477641008559 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 477641008560 generic binding surface II; other site 477641008561 generic binding surface I; other site 477641008562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641008563 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 477641008564 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 477641008565 active site 477641008566 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 477641008567 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 477641008568 malate:quinone oxidoreductase; Validated; Region: PRK05257 477641008569 potassium/proton antiporter; Reviewed; Region: PRK05326 477641008570 TrkA-C domain; Region: TrkA_C; pfam02080 477641008571 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 477641008572 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 477641008573 HIGH motif; other site 477641008574 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 477641008575 active site 477641008576 KMSKS motif; other site 477641008577 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 477641008578 tRNA binding surface [nucleotide binding]; other site 477641008579 anticodon binding site; other site 477641008580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641008581 DivIVA domain; Region: DivI1A_domain; TIGR03544 477641008582 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 477641008583 Protein of unknown function (DUF552); Region: DUF552; pfam04472 477641008584 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 477641008585 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 477641008586 catalytic residue [active] 477641008587 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 477641008588 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 477641008589 cell division protein FtsZ; Validated; Region: PRK09330 477641008590 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 477641008591 nucleotide binding site [chemical binding]; other site 477641008592 SulA interaction site; other site 477641008593 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 477641008594 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 477641008595 cell division protein FtsQ; Provisional; Region: PRK05529 477641008596 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 477641008597 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 477641008598 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641008599 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 477641008600 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 477641008601 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 477641008602 active site 477641008603 homodimer interface [polypeptide binding]; other site 477641008604 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 477641008605 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 477641008606 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641008607 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 477641008608 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 477641008609 Mg++ binding site [ion binding]; other site 477641008610 putative catalytic motif [active] 477641008611 putative substrate binding site [chemical binding]; other site 477641008612 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 477641008613 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 477641008614 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641008615 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 477641008616 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 477641008617 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 477641008618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 477641008619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 477641008620 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 477641008621 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 477641008622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 477641008623 MraW methylase family; Region: Methyltransf_5; cl17771 477641008624 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 477641008625 cell division protein MraZ; Reviewed; Region: PRK00326 477641008626 MraZ protein; Region: MraZ; pfam02381 477641008627 MraZ protein; Region: MraZ; pfam02381 477641008628 MoxR-like ATPases [General function prediction only]; Region: COG0714 477641008629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641008630 Walker A motif; other site 477641008631 ATP binding site [chemical binding]; other site 477641008632 Walker B motif; other site 477641008633 arginine finger; other site 477641008634 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 477641008635 Protein of unknown function DUF58; Region: DUF58; pfam01882 477641008636 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 477641008637 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 477641008638 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 477641008639 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 477641008640 active site 477641008641 DNA polymerase IV; Validated; Region: PRK02406 477641008642 DNA binding site [nucleotide binding] 477641008643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641008644 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641008645 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 477641008646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641008647 Cupin superfamily protein; Region: Cupin_4; pfam08007 477641008648 Cupin-like domain; Region: Cupin_8; pfam13621 477641008649 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 477641008650 putative dimer interface [polypeptide binding]; other site 477641008651 putative [2Fe-2S] cluster binding site [ion binding]; other site 477641008652 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 477641008653 Methyltransferase domain; Region: Methyltransf_23; pfam13489 477641008654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641008655 S-adenosylmethionine binding site [chemical binding]; other site 477641008656 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 477641008657 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 477641008658 active site 477641008659 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 477641008660 generic binding surface II; other site 477641008661 generic binding surface I; other site 477641008662 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641008663 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 477641008664 putative deacylase active site [active] 477641008665 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 477641008666 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 477641008667 Protein of unknown function (DUF422); Region: DUF422; cl00991 477641008668 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 477641008669 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 477641008670 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 477641008671 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 477641008672 substrate binding site [chemical binding]; other site 477641008673 ATP binding site [chemical binding]; other site 477641008674 Lipase (class 2); Region: Lipase_2; pfam01674 477641008675 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 477641008676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008677 ABC transporter; Region: ABC_tran; pfam00005 477641008678 Q-loop/lid; other site 477641008679 ABC transporter signature motif; other site 477641008680 Walker B; other site 477641008681 D-loop; other site 477641008682 H-loop/switch region; other site 477641008683 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 477641008684 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 477641008685 FAD binding site [chemical binding]; other site 477641008686 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 477641008687 substrate binding pocket [chemical binding]; other site 477641008688 chain length determination region; other site 477641008689 substrate-Mg2+ binding site; other site 477641008690 catalytic residues [active] 477641008691 aspartate-rich region 1; other site 477641008692 active site lid residues [active] 477641008693 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 477641008694 aspartate-rich region 2; other site 477641008695 phytoene desaturase; Region: crtI_fam; TIGR02734 477641008696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641008697 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 477641008698 active site lid residues [active] 477641008699 substrate binding pocket [chemical binding]; other site 477641008700 catalytic residues [active] 477641008701 substrate-Mg2+ binding site; other site 477641008702 aspartate-rich region 1; other site 477641008703 aspartate-rich region 2; other site 477641008704 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 477641008705 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 477641008706 Helix-turn-helix domain; Region: HTH_17; pfam12728 477641008707 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 477641008708 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 477641008709 active site 477641008710 substrate binding site [chemical binding]; other site 477641008711 FMN binding site [chemical binding]; other site 477641008712 putative catalytic residues [active] 477641008713 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641008714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 477641008715 active site 477641008716 ATP binding site [chemical binding]; other site 477641008717 substrate binding site [chemical binding]; other site 477641008718 activation loop (A-loop); other site 477641008719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 477641008720 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641008721 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641008722 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641008723 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641008724 AP endonuclease family 2; Region: AP2Ec; smart00518 477641008725 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 477641008726 AP (apurinic/apyrimidinic) site pocket; other site 477641008727 DNA interaction; other site 477641008728 Metal-binding active site; metal-binding site 477641008729 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 477641008730 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 477641008731 tetramer interface [polypeptide binding]; other site 477641008732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641008733 catalytic residue [active] 477641008734 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 477641008735 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 477641008736 phosphofructokinase; Region: PFK_mixed; TIGR02483 477641008737 active site 477641008738 ADP/pyrophosphate binding site [chemical binding]; other site 477641008739 dimerization interface [polypeptide binding]; other site 477641008740 allosteric effector site; other site 477641008741 fructose-1,6-bisphosphate binding site; other site 477641008742 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 477641008743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641008744 dimerization interface [polypeptide binding]; other site 477641008745 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641008746 putative CheW interface [polypeptide binding]; other site 477641008747 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641008748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 477641008749 putative acyl-acceptor binding pocket; other site 477641008750 Uncharacterized conserved protein [Function unknown]; Region: COG1915 477641008751 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 477641008752 homodimer interface [polypeptide binding]; other site 477641008753 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641008754 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641008755 nucleotide binding site [chemical binding]; other site 477641008756 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 477641008757 putative hydrophobic ligand binding site [chemical binding]; other site 477641008758 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 477641008759 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 477641008760 acyl-activating enzyme (AAE) consensus motif; other site 477641008761 putative AMP binding site [chemical binding]; other site 477641008762 putative active site [active] 477641008763 putative CoA binding site [chemical binding]; other site 477641008764 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641008765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641008766 Peptidase family M48; Region: Peptidase_M48; cl12018 477641008767 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641008768 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641008769 hypothetical protein; Validated; Region: PRK07883 477641008770 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 477641008771 active site 477641008772 catalytic site [active] 477641008773 substrate binding site [chemical binding]; other site 477641008774 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 477641008775 GIY-YIG motif/motif A; other site 477641008776 active site 477641008777 catalytic site [active] 477641008778 putative DNA binding site [nucleotide binding]; other site 477641008779 metal binding site [ion binding]; metal-binding site 477641008780 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 477641008781 AsnC family; Region: AsnC_trans_reg; pfam01037 477641008782 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 477641008783 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 477641008784 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 477641008785 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 477641008786 Subunit I/III interface [polypeptide binding]; other site 477641008787 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 477641008788 Cytochrome c; Region: Cytochrom_C; pfam00034 477641008789 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 477641008790 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 477641008791 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 477641008792 iron-sulfur cluster [ion binding]; other site 477641008793 [2Fe-2S] cluster binding site [ion binding]; other site 477641008794 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 477641008795 heme bH binding site [chemical binding]; other site 477641008796 intrachain domain interface; other site 477641008797 heme bL binding site [chemical binding]; other site 477641008798 interchain domain interface [polypeptide binding]; other site 477641008799 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 477641008800 Qo binding site; other site 477641008801 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 477641008802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641008803 substrate binding site [chemical binding]; other site 477641008804 oxyanion hole (OAH) forming residues; other site 477641008805 trimer interface [polypeptide binding]; other site 477641008806 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 477641008807 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 477641008808 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 477641008809 integral membrane protein; Region: integ_memb_HG; TIGR03954 477641008810 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 477641008811 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 477641008812 active site 477641008813 dimer interface [polypeptide binding]; other site 477641008814 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 477641008815 Ligand Binding Site [chemical binding]; other site 477641008816 Molecular Tunnel; other site 477641008817 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 477641008818 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 477641008819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641008820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641008821 active site 477641008822 catalytic tetrad [active] 477641008823 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 477641008824 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 477641008825 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 477641008826 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 477641008827 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641008828 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 477641008829 interface (dimer of trimers) [polypeptide binding]; other site 477641008830 multifunctional aminopeptidase A; Provisional; Region: PRK00913 477641008831 Substrate-binding/catalytic site; other site 477641008832 Zn-binding sites [ion binding]; other site 477641008833 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 477641008834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641008835 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641008836 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 477641008837 E3 interaction surface; other site 477641008838 lipoyl attachment site [posttranslational modification]; other site 477641008839 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 477641008840 E3 interaction surface; other site 477641008841 lipoyl attachment site [posttranslational modification]; other site 477641008842 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 477641008843 e3 binding domain; Region: E3_binding; pfam02817 477641008844 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 477641008845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641008846 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 477641008847 NAD(P) binding site [chemical binding]; other site 477641008848 active site 477641008849 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641008850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 477641008851 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 477641008852 substrate binding site [chemical binding]; other site 477641008853 activation loop (A-loop); other site 477641008854 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 477641008855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641008856 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 477641008857 active site pocket [active] 477641008858 oxyanion hole [active] 477641008859 catalytic triad [active] 477641008860 active site nucleophile [active] 477641008861 lipoate-protein ligase B; Provisional; Region: PRK14345 477641008862 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 477641008863 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 477641008864 HIGH motif; other site 477641008865 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 477641008866 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641008867 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 477641008868 active site 477641008869 KMSKS motif; other site 477641008870 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 477641008871 tRNA binding surface [nucleotide binding]; other site 477641008872 anticodon binding site; other site 477641008873 potential frameshift: common BLAST hit: gi|297560051|ref|YP_003679025.1| ABC transporter 477641008874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008875 H-loop/switch region; other site 477641008876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008877 Walker A/P-loop; other site 477641008878 ATP binding site [chemical binding]; other site 477641008879 Q-loop/lid; other site 477641008880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641008881 Histidine kinase; Region: HisKA_3; pfam07730 477641008882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641008883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641008884 active site 477641008885 phosphorylation site [posttranslational modification] 477641008886 intermolecular recognition site; other site 477641008887 dimerization interface [polypeptide binding]; other site 477641008888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641008889 DNA binding residues [nucleotide binding] 477641008890 dimerization interface [polypeptide binding]; other site 477641008891 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 477641008892 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641008893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641008894 salt bridge; other site 477641008895 non-specific DNA binding site [nucleotide binding]; other site 477641008896 sequence-specific DNA binding site [nucleotide binding]; other site 477641008897 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641008898 classical (c) SDRs; Region: SDR_c; cd05233 477641008899 NAD(P) binding site [chemical binding]; other site 477641008900 active site 477641008901 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 477641008902 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 477641008903 active site 477641008904 catalytic site [active] 477641008905 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 477641008906 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 477641008907 synthetase active site [active] 477641008908 NTP binding site [chemical binding]; other site 477641008909 metal binding site [ion binding]; metal-binding site 477641008910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 477641008911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641008912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641008913 active site 477641008914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641008915 Transmembrane secretion effector; Region: MFS_3; pfam05977 477641008916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641008917 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641008918 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641008919 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 477641008920 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 477641008921 Ycf46; Provisional; Region: ycf46; CHL00195 477641008922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641008923 Walker A motif; other site 477641008924 ATP binding site [chemical binding]; other site 477641008925 Walker B motif; other site 477641008926 arginine finger; other site 477641008927 Short C-terminal domain; Region: SHOCT; pfam09851 477641008928 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 477641008929 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 477641008930 NAD(P) binding site [chemical binding]; other site 477641008931 hypothetical protein; Provisional; Region: PRK13685 477641008932 von Willebrand factor type A domain; Region: VWA_2; pfam13519 477641008933 metal ion-dependent adhesion site (MIDAS); other site 477641008934 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 477641008935 Protein of unknown function DUF58; Region: DUF58; pfam01882 477641008936 MoxR-like ATPases [General function prediction only]; Region: COG0714 477641008937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641008938 Walker A motif; other site 477641008939 ATP binding site [chemical binding]; other site 477641008940 Walker B motif; other site 477641008941 arginine finger; other site 477641008942 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641008943 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641008944 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 477641008945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641008946 acyl-activating enzyme (AAE) consensus motif; other site 477641008947 AMP binding site [chemical binding]; other site 477641008948 active site 477641008949 CoA binding site [chemical binding]; other site 477641008950 NAD-dependent deacetylase; Provisional; Region: PRK00481 477641008951 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 477641008952 NAD+ binding site [chemical binding]; other site 477641008953 substrate binding site [chemical binding]; other site 477641008954 Zn binding site [ion binding]; other site 477641008955 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 477641008956 active site 477641008957 aconitate hydratase; Validated; Region: PRK09277 477641008958 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 477641008959 substrate binding site [chemical binding]; other site 477641008960 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 477641008961 ligand binding site [chemical binding]; other site 477641008962 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 477641008963 substrate binding site [chemical binding]; other site 477641008964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641008965 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 477641008966 NAD(P) binding site [chemical binding]; other site 477641008967 active site 477641008968 CbiX; Region: CbiX; pfam01903 477641008969 active site 477641008970 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 477641008971 putative active site [active] 477641008972 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 477641008973 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 477641008974 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 477641008975 active site residue [active] 477641008976 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 477641008977 active site residue [active] 477641008978 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 477641008979 SnoaL-like domain; Region: SnoaL_3; pfam13474 477641008980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 477641008981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 477641008982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008983 Walker A/P-loop; other site 477641008984 ATP binding site [chemical binding]; other site 477641008985 Q-loop/lid; other site 477641008986 ABC transporter signature motif; other site 477641008987 Walker B; other site 477641008988 D-loop; other site 477641008989 H-loop/switch region; other site 477641008990 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 477641008991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641008992 substrate binding site [chemical binding]; other site 477641008993 oxyanion hole (OAH) forming residues; other site 477641008994 trimer interface [polypeptide binding]; other site 477641008995 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 477641008996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641008997 Walker A/P-loop; other site 477641008998 ATP binding site [chemical binding]; other site 477641008999 Q-loop/lid; other site 477641009000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641009001 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641009002 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 477641009003 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 477641009004 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 477641009005 trimerization site [polypeptide binding]; other site 477641009006 active site 477641009007 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 477641009008 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 477641009009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641009010 catalytic residue [active] 477641009011 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 477641009012 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 477641009013 Walker A/P-loop; other site 477641009014 ATP binding site [chemical binding]; other site 477641009015 Q-loop/lid; other site 477641009016 ABC transporter signature motif; other site 477641009017 Walker B; other site 477641009018 D-loop; other site 477641009019 H-loop/switch region; other site 477641009020 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 477641009021 [2Fe-2S] cluster binding site [ion binding]; other site 477641009022 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 477641009023 FeS assembly protein SufD; Region: sufD; TIGR01981 477641009024 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 477641009025 FeS assembly protein SufB; Region: sufB; TIGR01980 477641009026 Predicted transcriptional regulator [Transcription]; Region: COG2345 477641009027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641009028 putative DNA binding site [nucleotide binding]; other site 477641009029 putative Zn2+ binding site [ion binding]; other site 477641009030 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 477641009031 Clp amino terminal domain; Region: Clp_N; pfam02861 477641009032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641009033 Walker A motif; other site 477641009034 ATP binding site [chemical binding]; other site 477641009035 Walker B motif; other site 477641009036 arginine finger; other site 477641009037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641009038 Walker A motif; other site 477641009039 ATP binding site [chemical binding]; other site 477641009040 Walker B motif; other site 477641009041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 477641009042 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 477641009043 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 477641009044 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 477641009045 UbiA prenyltransferase family; Region: UbiA; pfam01040 477641009046 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 477641009047 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 477641009048 TPP-binding site [chemical binding]; other site 477641009049 dimer interface [polypeptide binding]; other site 477641009050 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 477641009051 PYR/PP interface [polypeptide binding]; other site 477641009052 dimer interface [polypeptide binding]; other site 477641009053 TPP binding site [chemical binding]; other site 477641009054 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 477641009055 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 477641009056 putative active site [active] 477641009057 catalytic residue [active] 477641009058 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 477641009059 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 477641009060 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 477641009061 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 477641009062 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 477641009063 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 477641009064 putative active site [active] 477641009065 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 477641009066 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 477641009067 peptide binding site [polypeptide binding]; other site 477641009068 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641009069 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 477641009070 triosephosphate isomerase; Provisional; Region: PRK14567 477641009071 substrate binding site [chemical binding]; other site 477641009072 dimer interface [polypeptide binding]; other site 477641009073 catalytic triad [active] 477641009074 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 477641009075 Phosphoglycerate kinase; Region: PGK; pfam00162 477641009076 substrate binding site [chemical binding]; other site 477641009077 hinge regions; other site 477641009078 ADP binding site [chemical binding]; other site 477641009079 catalytic site [active] 477641009080 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 477641009081 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 477641009082 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 477641009083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 477641009084 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 477641009085 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 477641009086 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 477641009087 putative substrate binding pocket [chemical binding]; other site 477641009088 dimer interface [polypeptide binding]; other site 477641009089 phosphate binding site [ion binding]; other site 477641009090 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 477641009091 AAA domain; Region: AAA_18; pfam13238 477641009092 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 477641009093 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 477641009094 GIY-YIG motif/motif A; other site 477641009095 active site 477641009096 catalytic site [active] 477641009097 putative DNA binding site [nucleotide binding]; other site 477641009098 metal binding site [ion binding]; metal-binding site 477641009099 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 477641009100 Helix-hairpin-helix motif; Region: HHH; pfam00633 477641009101 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 477641009102 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641009103 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641009104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 477641009105 Ligand Binding Site [chemical binding]; other site 477641009106 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 477641009107 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 477641009108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 477641009109 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 477641009110 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 477641009111 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 477641009112 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 477641009113 amidase; Provisional; Region: PRK12470 477641009114 Amidase; Region: Amidase; cl11426 477641009115 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641009116 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 477641009117 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641009118 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641009119 classical (c) SDRs; Region: SDR_c; cd05233 477641009120 NAD(P) binding site [chemical binding]; other site 477641009121 active site 477641009122 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641009123 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 477641009124 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 477641009125 active site 477641009126 substrate binding site [chemical binding]; other site 477641009127 FMN binding site [chemical binding]; other site 477641009128 putative catalytic residues [active] 477641009129 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 477641009130 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641009131 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 477641009132 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641009133 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 477641009134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641009135 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 477641009136 active site 477641009137 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 477641009138 amphipathic channel; other site 477641009139 Asn-Pro-Ala signature motifs; other site 477641009140 Integral membrane protein TerC family; Region: TerC; cl10468 477641009141 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 477641009142 excinuclease ABC subunit B; Provisional; Region: PRK05298 477641009143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641009144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641009145 nucleotide binding region [chemical binding]; other site 477641009146 ATP-binding site [chemical binding]; other site 477641009147 Ultra-violet resistance protein B; Region: UvrB; pfam12344 477641009148 UvrB/uvrC motif; Region: UVR; pfam02151 477641009149 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 477641009150 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 477641009151 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 477641009152 active site 477641009153 catalytic site [active] 477641009154 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 477641009155 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 477641009156 active site 477641009157 catalytic site [active] 477641009158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641009159 RNA polymerase factor sigma-70; Validated; Region: PRK08241 477641009160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009162 DNA binding residues [nucleotide binding] 477641009163 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641009164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641009165 short chain dehydrogenase; Validated; Region: PRK08264 477641009166 NAD(P) binding site [chemical binding]; other site 477641009167 active site 477641009168 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 477641009169 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 477641009170 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 477641009171 catalytic site [active] 477641009172 active site 477641009173 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 477641009174 RibD C-terminal domain; Region: RibD_C; cl17279 477641009175 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641009176 active site 477641009177 metal binding site [ion binding]; metal-binding site 477641009178 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 477641009179 putative active site [active] 477641009180 putative CoA binding site [chemical binding]; other site 477641009181 nudix motif; other site 477641009182 metal binding site [ion binding]; metal-binding site 477641009183 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 477641009184 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 477641009185 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641009186 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641009187 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641009188 active site 477641009189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641009190 Coenzyme A binding pocket [chemical binding]; other site 477641009191 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 477641009192 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 477641009193 active site 477641009194 DNA binding site [nucleotide binding] 477641009195 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 477641009196 DNA binding site [nucleotide binding] 477641009197 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 477641009198 TAP-like protein; Region: Abhydrolase_4; pfam08386 477641009199 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641009200 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641009201 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 477641009202 nucleotide binding site [chemical binding]; other site 477641009203 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641009204 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 477641009205 active site 477641009206 Int/Topo IB signature motif; other site 477641009207 DNA binding site [nucleotide binding] 477641009208 Conserved TM helix; Region: TM_helix; pfam05552 477641009209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641009210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641009211 metal binding site [ion binding]; metal-binding site 477641009212 active site 477641009213 I-site; other site 477641009214 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 477641009215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 477641009217 DNA binding residues [nucleotide binding] 477641009218 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641009219 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641009220 ATP binding site [chemical binding]; other site 477641009221 Mg2+ binding site [ion binding]; other site 477641009222 G-X-G motif; other site 477641009223 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641009224 MarR family; Region: MarR_2; pfam12802 477641009225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009226 PAS fold; Region: PAS_3; pfam08447 477641009227 putative active site [active] 477641009228 heme pocket [chemical binding]; other site 477641009229 PAS domain; Region: PAS; smart00091 477641009230 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641009231 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 477641009232 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641009233 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 477641009234 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641009235 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641009236 GAF domain; Region: GAF; pfam01590 477641009237 GAF domain; Region: GAF_2; pfam13185 477641009238 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641009239 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641009240 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641009241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641009242 DNA binding residues [nucleotide binding] 477641009243 dimerization interface [polypeptide binding]; other site 477641009244 Uncharacterized conserved protein [Function unknown]; Region: COG1359 477641009245 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641009246 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 477641009247 NAD binding site [chemical binding]; other site 477641009248 substrate binding site [chemical binding]; other site 477641009249 catalytic Zn binding site [ion binding]; other site 477641009250 structural Zn binding site [ion binding]; other site 477641009251 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 477641009252 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 477641009253 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 477641009254 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 477641009255 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 477641009256 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 477641009257 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 477641009258 [2Fe-2S] cluster binding site [ion binding]; other site 477641009259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 477641009260 hydrophobic ligand binding site; other site 477641009261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641009262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641009263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 477641009264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641009265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641009266 putative Zn2+ binding site [ion binding]; other site 477641009267 putative DNA binding site [nucleotide binding]; other site 477641009268 Transposase; Region: HTH_Tnp_1; cl17663 477641009269 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 477641009270 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 477641009271 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 477641009272 TrwC relaxase; Region: TrwC; pfam08751 477641009273 AAA domain; Region: AAA_30; pfam13604 477641009274 Family description; Region: UvrD_C_2; pfam13538 477641009275 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 477641009276 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 477641009277 active site 477641009278 metal binding site [ion binding]; metal-binding site 477641009279 interdomain interaction site; other site 477641009280 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 477641009281 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641009282 NlpC/P60 family; Region: NLPC_P60; cl17555 477641009283 AAA-like domain; Region: AAA_10; pfam12846 477641009284 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 477641009285 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 477641009286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009287 DNA binding residues [nucleotide binding] 477641009288 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641009289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641009290 PRC-barrel domain; Region: PRC; pfam05239 477641009291 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 477641009292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 477641009293 Transposase; Region: HTH_Tnp_1; cl17663 477641009294 HTH-like domain; Region: HTH_21; pfam13276 477641009295 Integrase core domain; Region: rve; pfam00665 477641009296 Integrase core domain; Region: rve; pfam00665 477641009297 Integrase core domain; Region: rve_3; cl15866 477641009298 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 477641009299 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641009300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641009301 active site 477641009302 phosphorylation site [posttranslational modification] 477641009303 intermolecular recognition site; other site 477641009304 dimerization interface [polypeptide binding]; other site 477641009305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641009306 DNA binding residues [nucleotide binding] 477641009307 dimerization interface [polypeptide binding]; other site 477641009308 Histidine kinase; Region: HisKA_3; pfam07730 477641009309 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641009310 CAAX protease self-immunity; Region: Abi; pfam02517 477641009311 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 477641009312 putative transposase OrfB; Reviewed; Region: PHA02517 477641009313 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641009314 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641009315 ATP binding site [chemical binding]; other site 477641009316 Mg2+ binding site [ion binding]; other site 477641009317 G-X-G motif; other site 477641009318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009319 PAS domain; Region: PAS_9; pfam13426 477641009320 putative active site [active] 477641009321 heme pocket [chemical binding]; other site 477641009322 GAF domain; Region: GAF; pfam01590 477641009323 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641009324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641009325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009326 PAS domain; Region: PAS_9; pfam13426 477641009327 putative active site [active] 477641009328 heme pocket [chemical binding]; other site 477641009329 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641009330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641009331 metal binding site [ion binding]; metal-binding site 477641009332 active site 477641009333 I-site; other site 477641009334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641009335 Response regulator receiver domain; Region: Response_reg; pfam00072 477641009336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641009337 active site 477641009338 phosphorylation site [posttranslational modification] 477641009339 intermolecular recognition site; other site 477641009340 dimerization interface [polypeptide binding]; other site 477641009341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641009342 ATP binding site [chemical binding]; other site 477641009343 Mg2+ binding site [ion binding]; other site 477641009344 G-X-G motif; other site 477641009345 GAF domain; Region: GAF_2; pfam13185 477641009346 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641009347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641009348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641009349 dimer interface [polypeptide binding]; other site 477641009350 putative CheW interface [polypeptide binding]; other site 477641009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641009352 dimerization interface [polypeptide binding]; other site 477641009353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641009354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641009355 metal binding site [ion binding]; metal-binding site 477641009356 active site 477641009357 I-site; other site 477641009358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641009359 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641009360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009362 DNA binding residues [nucleotide binding] 477641009363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641009364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641009365 DNA binding residues [nucleotide binding] 477641009366 dimerization interface [polypeptide binding]; other site 477641009367 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 477641009368 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 477641009369 NAD binding site [chemical binding]; other site 477641009370 catalytic Zn binding site [ion binding]; other site 477641009371 structural Zn binding site [ion binding]; other site 477641009372 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 477641009373 intracellular protease, PfpI family; Region: PfpI; TIGR01382 477641009374 proposed catalytic triad [active] 477641009375 conserved cys residue [active] 477641009376 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641009377 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641009378 NAD binding site [chemical binding]; other site 477641009379 catalytic Zn binding site [ion binding]; other site 477641009380 structural Zn binding site [ion binding]; other site 477641009381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009382 Homeodomain-like domain; Region: HTH_23; cl17451 477641009383 Winged helix-turn helix; Region: HTH_29; pfam13551 477641009384 Integrase core domain; Region: rve; pfam00665 477641009385 Integrase core domain; Region: rve_3; pfam13683 477641009386 Integral membrane protein TerC family; Region: TerC; cl10468 477641009387 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 477641009388 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 477641009389 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 477641009390 Domain of Unknown Function (DUF1907); Region: DUF1907; pfam08925 477641009391 multiple promoter invertase; Provisional; Region: mpi; PRK13413 477641009392 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 477641009393 catalytic residues [active] 477641009394 catalytic nucleophile [active] 477641009395 Presynaptic Site I dimer interface [polypeptide binding]; other site 477641009396 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 477641009397 Synaptic Flat tetramer interface [polypeptide binding]; other site 477641009398 Synaptic Site I dimer interface [polypeptide binding]; other site 477641009399 DNA binding site [nucleotide binding] 477641009400 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 477641009401 DNA-binding interface [nucleotide binding]; DNA binding site 477641009402 PAS fold; Region: PAS_4; pfam08448 477641009403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009404 putative active site [active] 477641009405 heme pocket [chemical binding]; other site 477641009406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009407 PAS domain; Region: PAS_9; pfam13426 477641009408 putative active site [active] 477641009409 heme pocket [chemical binding]; other site 477641009410 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641009411 GAF domain; Region: GAF_3; pfam13492 477641009412 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641009413 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 477641009414 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641009415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641009416 ATP binding site [chemical binding]; other site 477641009417 Mg2+ binding site [ion binding]; other site 477641009418 G-X-G motif; other site 477641009419 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 477641009420 Lsr2; Region: Lsr2; pfam11774 477641009421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641009422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641009423 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 477641009424 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641009425 Walker A motif; other site 477641009426 ATP binding site [chemical binding]; other site 477641009427 Walker B motif; other site 477641009428 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 477641009429 putative transposase OrfB; Reviewed; Region: PHA02517 477641009430 HTH-like domain; Region: HTH_21; pfam13276 477641009431 Integrase core domain; Region: rve; pfam00665 477641009432 Integrase core domain; Region: rve_2; pfam13333 477641009433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 477641009434 Transposase; Region: HTH_Tnp_1; cl17663 477641009435 HAMP domain; Region: HAMP; pfam00672 477641009436 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641009437 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641009438 dimer interface [polypeptide binding]; other site 477641009439 putative CheW interface [polypeptide binding]; other site 477641009440 PAS domain; Region: PAS_9; pfam13426 477641009441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009442 putative active site [active] 477641009443 heme pocket [chemical binding]; other site 477641009444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009445 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 477641009446 putative active site [active] 477641009447 heme pocket [chemical binding]; other site 477641009448 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 477641009449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009450 putative active site [active] 477641009451 heme pocket [chemical binding]; other site 477641009452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009453 putative active site [active] 477641009454 heme pocket [chemical binding]; other site 477641009455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009456 PAS domain; Region: PAS_9; pfam13426 477641009457 putative active site [active] 477641009458 heme pocket [chemical binding]; other site 477641009459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009460 PAS domain; Region: PAS_9; pfam13426 477641009461 putative active site [active] 477641009462 heme pocket [chemical binding]; other site 477641009463 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641009464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641009465 dimer interface [polypeptide binding]; other site 477641009466 putative CheW interface [polypeptide binding]; other site 477641009467 CheW-like domain; Region: CheW; pfam01584 477641009468 CheW-like domain; Region: CheW; pfam01584 477641009469 CheW-like domain; Region: CheW; pfam01584 477641009470 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 477641009471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641009472 dimerization interface [polypeptide binding]; other site 477641009473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641009474 dimer interface [polypeptide binding]; other site 477641009475 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 477641009476 putative CheW interface [polypeptide binding]; other site 477641009477 PAS domain S-box; Region: sensory_box; TIGR00229 477641009478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641009479 putative active site [active] 477641009480 heme pocket [chemical binding]; other site 477641009481 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641009482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641009483 metal binding site [ion binding]; metal-binding site 477641009484 active site 477641009485 I-site; other site 477641009486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641009487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641009488 DNA binding residues [nucleotide binding] 477641009489 dimerization interface [polypeptide binding]; other site 477641009490 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 477641009491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641009492 DoxX-like family; Region: DoxX_2; pfam13564 477641009493 YCII-related domain; Region: YCII; cl00999 477641009494 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 477641009495 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 477641009496 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 477641009497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 477641009498 Walker A/P-loop; other site 477641009499 ATP binding site [chemical binding]; other site 477641009500 Q-loop/lid; other site 477641009501 ABC transporter signature motif; other site 477641009502 Walker B; other site 477641009503 D-loop; other site 477641009504 H-loop/switch region; other site 477641009505 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641009506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641009507 Protein of unknown function (DUF664); Region: DUF664; pfam04978 477641009508 DinB superfamily; Region: DinB_2; pfam12867 477641009509 Asp23 family; Region: Asp23; pfam03780 477641009510 Asp23 family; Region: Asp23; pfam03780 477641009511 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 477641009512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009514 Asp23 family; Region: Asp23; cl00574 477641009515 potential frameshift: common BLAST hit: gi|332671969|ref|YP_004454977.1| integrase catalytic subunit 477641009516 Integrase core domain; Region: rve; pfam00665 477641009517 Integrase core domain; Region: rve_3; cl15866 477641009518 Transposase; Region: HTH_Tnp_1; cl17663 477641009519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 477641009520 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 477641009521 Helix-turn-helix domain; Region: HTH_38; pfam13936 477641009522 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 477641009523 23S rRNA interface [nucleotide binding]; other site 477641009524 Integrase core domain; Region: rve; pfam00665 477641009525 HTH-like domain; Region: HTH_21; pfam13276 477641009526 Integrase core domain; Region: rve; pfam00665 477641009527 Integrase core domain; Region: rve_3; pfam13683 477641009528 Transposase; Region: HTH_Tnp_1; cl17663 477641009529 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641009530 LGFP repeat; Region: LGFP; pfam08310 477641009531 LGFP repeat; Region: LGFP; pfam08310 477641009532 LGFP repeat; Region: LGFP; pfam08310 477641009533 RHS Repeat; Region: RHS_repeat; pfam05593 477641009534 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 477641009535 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 477641009536 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 477641009537 active site 477641009538 Int/Topo IB signature motif; other site 477641009539 catalytic residues [active] 477641009540 DNA binding site [nucleotide binding] 477641009541 TIR domain; Region: TIR_2; pfam13676 477641009542 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641009543 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 477641009544 NAD(P) binding site [chemical binding]; other site 477641009545 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641009546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641009547 active site 477641009548 metal binding site [ion binding]; metal-binding site 477641009549 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 477641009550 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 477641009551 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 477641009552 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641009553 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641009554 Serine hydrolase; Region: Ser_hydrolase; cl17834 477641009555 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 477641009556 Ligand Binding Site [chemical binding]; other site 477641009557 Dienelactone hydrolase family; Region: DLH; pfam01738 477641009558 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 477641009559 hypothetical protein; Provisional; Region: PRK07236 477641009560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641009561 Transport protein; Region: actII; TIGR00833 477641009562 YCII-related domain; Region: YCII; cl00999 477641009563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 477641009564 DNA-binding site [nucleotide binding]; DNA binding site 477641009565 RNA-binding motif; other site 477641009566 methionine sulfoxide reductase B; Provisional; Region: PRK00222 477641009567 SelR domain; Region: SelR; pfam01641 477641009568 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 477641009569 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 477641009570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641009571 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 477641009572 substrate binding site [chemical binding]; other site 477641009573 active site 477641009574 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 477641009575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641009576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 477641009577 active site 477641009578 phosphorylation site [posttranslational modification] 477641009579 intermolecular recognition site; other site 477641009580 dimerization interface [polypeptide binding]; other site 477641009581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641009582 DNA binding residues [nucleotide binding] 477641009583 dimerization interface [polypeptide binding]; other site 477641009584 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 477641009585 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 477641009586 catalytic site [active] 477641009587 putative active site [active] 477641009588 putative substrate binding site [chemical binding]; other site 477641009589 Helicase and RNase D C-terminal; Region: HRDC; smart00341 477641009590 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 477641009591 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641009592 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 477641009593 dimer interface [polypeptide binding]; other site 477641009594 active site 477641009595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641009596 substrate binding site [chemical binding]; other site 477641009597 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 477641009598 oxyanion hole (OAH) forming residues; other site 477641009599 trimer interface [polypeptide binding]; other site 477641009600 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 477641009601 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 477641009602 Domain of unknown function DUF77; Region: DUF77; cl00307 477641009603 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 477641009604 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 477641009605 TPP-binding site; other site 477641009606 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 477641009607 PYR/PP interface [polypeptide binding]; other site 477641009608 dimer interface [polypeptide binding]; other site 477641009609 TPP binding site [chemical binding]; other site 477641009610 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 477641009611 TRAM domain; Region: TRAM; pfam01938 477641009612 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 477641009613 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641009614 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 477641009615 TrkA-N domain; Region: TrkA_N; pfam02254 477641009616 TrkA-C domain; Region: TrkA_C; pfam02080 477641009617 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 477641009618 TrkA-N domain; Region: TrkA_N; pfam02254 477641009619 TrkA-C domain; Region: TrkA_C; pfam02080 477641009620 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 477641009621 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 477641009622 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 477641009623 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641009624 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 477641009625 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 477641009626 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 477641009627 trimer interface [polypeptide binding]; other site 477641009628 active site 477641009629 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 477641009630 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 477641009631 Phosphotransferase enzyme family; Region: APH; pfam01636 477641009632 putative active site [active] 477641009633 putative substrate binding site [chemical binding]; other site 477641009634 ATP binding site [chemical binding]; other site 477641009635 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 477641009636 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 477641009637 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 477641009638 active site 477641009639 dimerization interface [polypeptide binding]; other site 477641009640 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 477641009641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 477641009642 nucleotide binding site [chemical binding]; other site 477641009643 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 477641009644 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 477641009645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009646 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 477641009647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009648 DNA binding residues [nucleotide binding] 477641009649 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 477641009650 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 477641009651 VanW like protein; Region: VanW; pfam04294 477641009652 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 477641009653 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 477641009654 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 477641009655 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 477641009656 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 477641009657 ATP binding site [chemical binding]; other site 477641009658 substrate binding site [chemical binding]; other site 477641009659 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 477641009660 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641009661 RibD C-terminal domain; Region: RibD_C; cl17279 477641009662 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641009663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641009664 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 477641009665 cyclase homology domain; Region: CHD; cd07302 477641009666 nucleotidyl binding site; other site 477641009667 metal binding site [ion binding]; metal-binding site 477641009668 dimer interface [polypeptide binding]; other site 477641009669 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 477641009670 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 477641009671 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 477641009672 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641009673 Sulfate transporter family; Region: Sulfate_transp; pfam00916 477641009674 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 477641009675 Uncharacterized conserved protein [Function unknown]; Region: COG5361 477641009676 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 477641009677 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 477641009678 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 477641009679 putative active site [active] 477641009680 dimerization interface [polypeptide binding]; other site 477641009681 putative tRNAtyr binding site [nucleotide binding]; other site 477641009682 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 477641009683 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 477641009684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641009685 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 477641009686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641009687 DNA binding residues [nucleotide binding] 477641009688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641009689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641009690 Coenzyme A binding pocket [chemical binding]; other site 477641009691 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 477641009692 CoA binding domain; Region: CoA_binding_2; pfam13380 477641009693 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 477641009694 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 477641009695 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 477641009696 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 477641009697 active site 477641009698 Zn binding site [ion binding]; other site 477641009699 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 477641009700 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 477641009701 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 477641009702 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 477641009703 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641009704 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641009705 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 477641009706 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 477641009707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641009708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641009709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641009710 S-adenosylmethionine binding site [chemical binding]; other site 477641009711 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 477641009712 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 477641009713 Protein of unknown function, DUF608; Region: DUF608; pfam04685 477641009714 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641009715 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 477641009716 active site 477641009717 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 477641009718 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 477641009719 Probable Catalytic site; other site 477641009720 metal-binding site 477641009721 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 477641009722 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 477641009723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641009724 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 477641009725 Walker A/P-loop; other site 477641009726 ATP binding site [chemical binding]; other site 477641009727 Q-loop/lid; other site 477641009728 ABC transporter signature motif; other site 477641009729 Walker B; other site 477641009730 D-loop; other site 477641009731 H-loop/switch region; other site 477641009732 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 477641009733 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641009734 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641009735 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 477641009736 Predicted ATPase [General function prediction only]; Region: COG3903 477641009737 Methyltransferase domain; Region: Methyltransf_24; pfam13578 477641009738 YibE/F-like protein; Region: YibE_F; pfam07907 477641009739 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 477641009740 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 477641009741 metal binding site [ion binding]; metal-binding site 477641009742 dimer interface [polypeptide binding]; other site 477641009743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641009744 short chain dehydrogenase; Provisional; Region: PRK06197 477641009745 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 477641009746 putative NAD(P) binding site [chemical binding]; other site 477641009747 active site 477641009748 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 477641009749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641009750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641009751 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 477641009752 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 477641009753 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 477641009754 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 477641009755 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 477641009756 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 477641009757 putative dimer interface [polypeptide binding]; other site 477641009758 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641009759 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 477641009760 DNA binding residues [nucleotide binding] 477641009761 Penicillinase repressor; Region: Pencillinase_R; cl17580 477641009762 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 477641009763 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 477641009764 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 477641009765 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 477641009766 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 477641009767 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641009768 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 477641009769 Walker A/P-loop; other site 477641009770 ATP binding site [chemical binding]; other site 477641009771 Q-loop/lid; other site 477641009772 ABC transporter signature motif; other site 477641009773 Walker B; other site 477641009774 D-loop; other site 477641009775 H-loop/switch region; other site 477641009776 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 477641009777 Walker A/P-loop; other site 477641009778 ATP binding site [chemical binding]; other site 477641009779 Q-loop/lid; other site 477641009780 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 477641009781 H/ACA RNA-protein complex component Cbf5p; Reviewed; Region: PRK04270 477641009782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641009783 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641009784 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641009785 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 477641009786 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 477641009787 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 477641009788 ethanolamine permease; Region: 2A0305; TIGR00908 477641009789 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 477641009790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641009791 catalytic residue [active] 477641009792 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 477641009793 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 477641009794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641009795 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641009796 TIGR03086 family protein; Region: TIGR03086 477641009797 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 477641009798 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 477641009799 FAD binding pocket [chemical binding]; other site 477641009800 FAD binding motif [chemical binding]; other site 477641009801 phosphate binding motif [ion binding]; other site 477641009802 NAD binding pocket [chemical binding]; other site 477641009803 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641009804 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641009805 putative active site [active] 477641009806 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 477641009807 RNase_H superfamily; Region: RNase_H_2; pfam13482 477641009808 AAA domain; Region: AAA_30; pfam13604 477641009809 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 477641009810 AAA domain; Region: AAA_12; pfam13087 477641009811 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 477641009812 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 477641009813 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 477641009814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641009815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641009816 DNA binding site [nucleotide binding] 477641009817 domain linker motif; other site 477641009818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 477641009819 dimerization interface [polypeptide binding]; other site 477641009820 ligand binding site [chemical binding]; other site 477641009821 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 477641009822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641009823 dimer interface [polypeptide binding]; other site 477641009824 active site 477641009825 short chain dehydrogenase; Provisional; Region: PRK06841 477641009826 classical (c) SDRs; Region: SDR_c; cd05233 477641009827 NAD(P) binding site [chemical binding]; other site 477641009828 active site 477641009829 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641009830 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 477641009831 active site 477641009832 hypothetical protein; Provisional; Region: PRK08201 477641009833 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 477641009834 metal binding site [ion binding]; metal-binding site 477641009835 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 477641009836 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 477641009837 metal binding site [ion binding]; metal-binding site 477641009838 substrate binding pocket [chemical binding]; other site 477641009839 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 477641009840 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641009841 catalytic Zn binding site [ion binding]; other site 477641009842 NAD(P) binding site [chemical binding]; other site 477641009843 structural Zn binding site [ion binding]; other site 477641009844 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 477641009845 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 477641009846 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 477641009847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641009848 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641009849 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 477641009850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641009851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641009852 NAD(P) binding site [chemical binding]; other site 477641009853 active site 477641009854 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 477641009855 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 477641009856 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 477641009857 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 477641009858 catalytic nucleophile [active] 477641009859 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 477641009860 SxDxEG motif; other site 477641009861 active site 477641009862 metal binding site [ion binding]; metal-binding site 477641009863 homopentamer interface [polypeptide binding]; other site 477641009864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641009865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641009866 Walker A/P-loop; other site 477641009867 ATP binding site [chemical binding]; other site 477641009868 Q-loop/lid; other site 477641009869 ABC transporter signature motif; other site 477641009870 Walker B; other site 477641009871 D-loop; other site 477641009872 H-loop/switch region; other site 477641009873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641009874 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641009875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641009876 Walker A/P-loop; other site 477641009877 ATP binding site [chemical binding]; other site 477641009878 Q-loop/lid; other site 477641009879 ABC transporter signature motif; other site 477641009880 Walker B; other site 477641009881 D-loop; other site 477641009882 H-loop/switch region; other site 477641009883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641009884 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641009885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641009886 dimer interface [polypeptide binding]; other site 477641009887 conserved gate region; other site 477641009888 putative PBP binding loops; other site 477641009889 ABC-ATPase subunit interface; other site 477641009890 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 477641009891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641009892 dimer interface [polypeptide binding]; other site 477641009893 conserved gate region; other site 477641009894 putative PBP binding loops; other site 477641009895 ABC-ATPase subunit interface; other site 477641009896 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 477641009897 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 477641009898 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 477641009899 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 477641009900 active site 477641009901 Zn binding site [ion binding]; other site 477641009902 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 477641009903 active site 477641009904 Response regulator receiver domain; Region: Response_reg; pfam00072 477641009905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641009906 active site 477641009907 phosphorylation site [posttranslational modification] 477641009908 intermolecular recognition site; other site 477641009909 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 477641009910 dimerization interface [polypeptide binding]; other site 477641009911 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 477641009912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641009913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641009914 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 477641009915 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641009916 ligand binding site [chemical binding]; other site 477641009917 flexible hinge region; other site 477641009918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641009919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641009920 ATP binding site [chemical binding]; other site 477641009921 Mg2+ binding site [ion binding]; other site 477641009922 G-X-G motif; other site 477641009923 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 477641009924 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641009925 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 477641009926 CoenzymeA binding site [chemical binding]; other site 477641009927 subunit interaction site [polypeptide binding]; other site 477641009928 PHB binding site; other site 477641009929 Ferritin-like domain; Region: Ferritin; pfam00210 477641009930 tetracycline repressor protein TetR; Provisional; Region: PRK13756 477641009931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641009932 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 477641009933 PRC-barrel domain; Region: PRC; pfam05239 477641009934 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 477641009935 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 477641009936 Part of AAA domain; Region: AAA_19; pfam13245 477641009937 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 477641009938 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 477641009939 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 477641009940 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 477641009941 putative NAD(P) binding site [chemical binding]; other site 477641009942 active site 477641009943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641009944 salt bridge; other site 477641009945 non-specific DNA binding site [nucleotide binding]; other site 477641009946 sequence-specific DNA binding site [nucleotide binding]; other site 477641009947 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 477641009948 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 477641009949 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641009950 nudix motif; other site 477641009951 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 477641009952 hypothetical protein; Reviewed; Region: PRK09588 477641009953 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 477641009954 Cytochrome C biogenesis protein; Region: CcmH; cl01179 477641009955 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 477641009956 catalytic triad [active] 477641009957 Isochorismatase family; Region: Isochorismatase; pfam00857 477641009958 conserved cis-peptide bond; other site 477641009959 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 477641009960 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 477641009961 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641009962 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641009963 Transcriptional regulators [Transcription]; Region: FadR; COG2186 477641009964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 477641009965 DNA-binding site [nucleotide binding]; DNA binding site 477641009966 FCD domain; Region: FCD; pfam07729 477641009967 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 477641009968 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 477641009969 tetramer interface [polypeptide binding]; other site 477641009970 active site 477641009971 Mg2+/Mn2+ binding site [ion binding]; other site 477641009972 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 477641009973 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 477641009974 active site 477641009975 metal binding site [ion binding]; metal-binding site 477641009976 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 477641009977 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 477641009978 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 477641009979 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 477641009980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641009981 Walker A motif; other site 477641009982 ATP binding site [chemical binding]; other site 477641009983 Walker B motif; other site 477641009984 arginine finger; other site 477641009985 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 477641009986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641009987 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641009988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641009989 active site 477641009990 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641009991 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 477641009992 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641009993 DNA binding residues [nucleotide binding] 477641009994 drug binding residues [chemical binding]; other site 477641009995 dimer interface [polypeptide binding]; other site 477641009996 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 477641009997 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641009998 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641009999 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641010000 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 477641010001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641010002 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 477641010003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641010004 Epoxide hydrolase N terminus; Region: EHN; pfam06441 477641010005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641010006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010007 NADH(P)-binding; Region: NAD_binding_10; pfam13460 477641010008 NAD(P) binding site [chemical binding]; other site 477641010009 active site 477641010010 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 477641010011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 477641010012 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 477641010013 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 477641010014 TAP-like protein; Region: Abhydrolase_4; pfam08386 477641010015 Nuclease-related domain; Region: NERD; pfam08378 477641010016 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 477641010017 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641010018 active site 477641010019 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641010020 putative catalytic site [active] 477641010021 putative phosphate binding site [ion binding]; other site 477641010022 putative metal binding site [ion binding]; other site 477641010023 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 477641010024 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 477641010025 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 477641010026 Staphylococcal nuclease homologue; Region: SNase; pfam00565 477641010027 Catalytic site; other site 477641010028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641010029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641010030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010031 NmrA-like family; Region: NmrA; pfam05368 477641010032 NAD(P) binding site [chemical binding]; other site 477641010033 active site 477641010034 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 477641010035 active site 477641010036 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 477641010037 active site 477641010038 Transglycosylase; Region: Transgly; pfam00912 477641010039 Helix-turn-helix domain; Region: HTH_17; pfam12728 477641010040 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 477641010041 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641010042 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 477641010043 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 477641010044 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 477641010045 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641010046 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641010047 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 477641010048 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 477641010049 active site 477641010050 putative substrate binding pocket [chemical binding]; other site 477641010051 Evidence 4 : Homologs of previously reported genes of unknown function 477641010052 Evidence 4 : Homologs of previously reported genes of unknown function 477641010053 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 477641010054 Fic/DOC family; Region: Fic; cl00960 477641010055 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641010056 putative catalytic site [active] 477641010057 putative phosphate binding site [ion binding]; other site 477641010058 putative metal binding site [ion binding]; other site 477641010059 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 477641010060 active site 477641010061 catalytic site [active] 477641010062 substrate binding site [chemical binding]; other site 477641010063 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 477641010064 Dimer interface [polypeptide binding]; other site 477641010065 BRCT sequence motif; other site 477641010066 HTH-like domain; Region: HTH_21; pfam13276 477641010067 Integrase core domain; Region: rve; pfam00665 477641010068 Integrase core domain; Region: rve_3; pfam13683 477641010069 Transposase; Region: HTH_Tnp_1; cl17663 477641010070 Nuclease-related domain; Region: NERD; pfam08378 477641010071 Part of AAA domain; Region: AAA_19; pfam13245 477641010072 Family description; Region: UvrD_C_2; pfam13538 477641010073 Evidence 4 : Homologs of previously reported genes of unknown function 477641010074 Evidence 4 : Homologs of previously reported genes of unknown function 477641010075 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 477641010076 nudix motif; other site 477641010077 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 477641010078 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 477641010079 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 477641010080 active site 477641010081 catalytic residues [active] 477641010082 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 477641010083 putative homodimer interface [polypeptide binding]; other site 477641010084 PLD-like domain; Region: PLDc_2; pfam13091 477641010085 putative active site [active] 477641010086 catalytic site [active] 477641010087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 477641010088 putative Mg++ binding site [ion binding]; other site 477641010089 helicase superfamily c-terminal domain; Region: HELICc; smart00490 477641010090 ATP-binding site [chemical binding]; other site 477641010091 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 477641010092 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 477641010093 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 477641010094 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 477641010095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641010096 ATP binding site [chemical binding]; other site 477641010097 putative Mg++ binding site [ion binding]; other site 477641010098 nucleotide binding region [chemical binding]; other site 477641010099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 477641010100 ATP-binding site [chemical binding]; other site 477641010101 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 477641010102 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 477641010103 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 477641010104 HsdM N-terminal domain; Region: HsdM_N; pfam12161 477641010105 Methyltransferase domain; Region: Methyltransf_26; pfam13659 477641010106 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 477641010107 DEAD/DEAH box helicase; Region: DEAD; pfam00270 477641010108 nucleotide binding region [chemical binding]; other site 477641010109 helicase superfamily c-terminal domain; Region: HELICc; smart00490 477641010110 ATP-binding site [chemical binding]; other site 477641010111 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 477641010112 Restriction endonuclease; Region: Mrr_cat; pfam04471 477641010113 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641010114 putative active site [active] 477641010115 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 477641010116 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 477641010117 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 477641010118 cofactor binding site; other site 477641010119 DNA binding site [nucleotide binding] 477641010120 substrate interaction site [chemical binding]; other site 477641010121 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 477641010122 Uncharacterized conserved protein [Function unknown]; Region: COG1479 477641010123 Protein of unknown function DUF262; Region: DUF262; pfam03235 477641010124 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 477641010125 Nuclease-related domain; Region: NERD; pfam08378 477641010126 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 477641010127 nucleoside/Zn binding site; other site 477641010128 dimer interface [polypeptide binding]; other site 477641010129 catalytic motif [active] 477641010130 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 477641010131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641010132 TM-ABC transporter signature motif; other site 477641010133 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 477641010134 TM-ABC transporter signature motif; other site 477641010135 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 477641010136 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641010137 Walker A/P-loop; other site 477641010138 ATP binding site [chemical binding]; other site 477641010139 Q-loop/lid; other site 477641010140 ABC transporter signature motif; other site 477641010141 Walker B; other site 477641010142 D-loop; other site 477641010143 H-loop/switch region; other site 477641010144 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641010145 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 477641010146 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 477641010147 putative ligand binding site [chemical binding]; other site 477641010148 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 477641010149 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641010150 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 477641010151 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 477641010152 NMT1/THI5 like; Region: NMT1; pfam09084 477641010153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 477641010154 substrate binding pocket [chemical binding]; other site 477641010155 membrane-bound complex binding site; other site 477641010156 hinge residues; other site 477641010157 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 477641010158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010159 dimer interface [polypeptide binding]; other site 477641010160 conserved gate region; other site 477641010161 putative PBP binding loops; other site 477641010162 ABC-ATPase subunit interface; other site 477641010163 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 477641010164 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 477641010165 Walker A/P-loop; other site 477641010166 ATP binding site [chemical binding]; other site 477641010167 Q-loop/lid; other site 477641010168 ABC transporter signature motif; other site 477641010169 Walker B; other site 477641010170 D-loop; other site 477641010171 H-loop/switch region; other site 477641010172 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 477641010173 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 477641010174 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641010175 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641010176 Transglutaminase family; Region: Transglut_N; pfam00868 477641010177 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641010178 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641010179 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 477641010180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641010181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641010182 DNA binding residues [nucleotide binding] 477641010183 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 477641010184 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641010185 nudix motif; other site 477641010186 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 477641010187 putative active site [active] 477641010188 metal binding site [ion binding]; metal-binding site 477641010189 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 477641010190 putative active site [active] 477641010191 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641010192 Amidase; Region: Amidase; cl11426 477641010193 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 477641010194 active site 477641010195 putative catalytic site [active] 477641010196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641010197 acyl-CoA synthetase; Validated; Region: PRK06188 477641010198 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 477641010199 putative active site [active] 477641010200 putative CoA binding site [chemical binding]; other site 477641010201 putative AMP binding site [chemical binding]; other site 477641010202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010204 NAD(P) binding site [chemical binding]; other site 477641010205 active site 477641010206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641010207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641010208 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 477641010209 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 477641010210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 477641010211 active site 477641010212 ATP binding site [chemical binding]; other site 477641010213 substrate binding site [chemical binding]; other site 477641010214 activation loop (A-loop); other site 477641010215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 477641010216 Excalibur calcium-binding domain; Region: Excalibur; cl05460 477641010217 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 477641010218 active site 477641010219 putative catalytic site [active] 477641010220 phenylhydantoinase; Validated; Region: PRK08323 477641010221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641010222 active site 477641010223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641010224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641010225 active site 477641010226 phosphorylation site [posttranslational modification] 477641010227 intermolecular recognition site; other site 477641010228 dimerization interface [polypeptide binding]; other site 477641010229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641010230 DNA binding residues [nucleotide binding] 477641010231 dimerization interface [polypeptide binding]; other site 477641010232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641010233 Histidine kinase; Region: HisKA_3; pfam07730 477641010234 MMPL family; Region: MMPL; pfam03176 477641010235 MMPL family; Region: MMPL; pfam03176 477641010236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641010237 salt bridge; other site 477641010238 Cupin domain; Region: Cupin_2; pfam07883 477641010239 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 477641010240 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 477641010241 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 477641010242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010243 dimer interface [polypeptide binding]; other site 477641010244 conserved gate region; other site 477641010245 ABC-ATPase subunit interface; other site 477641010246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 477641010247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010248 dimer interface [polypeptide binding]; other site 477641010249 conserved gate region; other site 477641010250 ABC-ATPase subunit interface; other site 477641010251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 477641010252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641010253 Walker A/P-loop; other site 477641010254 ATP binding site [chemical binding]; other site 477641010255 Q-loop/lid; other site 477641010256 ABC transporter signature motif; other site 477641010257 Walker B; other site 477641010258 D-loop; other site 477641010259 H-loop/switch region; other site 477641010260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641010261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 477641010262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 477641010263 Walker A/P-loop; other site 477641010264 ATP binding site [chemical binding]; other site 477641010265 Q-loop/lid; other site 477641010266 ABC transporter signature motif; other site 477641010267 Walker B; other site 477641010268 D-loop; other site 477641010269 H-loop/switch region; other site 477641010270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 477641010271 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641010272 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641010273 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641010274 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 477641010275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641010276 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 477641010277 active site 477641010278 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641010279 Amino acid permease; Region: AA_permease_2; pfam13520 477641010280 classical (c) SDRs; Region: SDR_c; cd05233 477641010281 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 477641010282 NAD(P) binding site [chemical binding]; other site 477641010283 active site 477641010284 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 477641010285 tyramine oxidase; Provisional; Region: tynA; PRK11504 477641010286 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 477641010287 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 477641010288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641010289 Uncharacterized conserved protein [Function unknown]; Region: COG3342 477641010290 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 477641010291 oxidoreductase; Provisional; Region: PRK06128 477641010292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010293 NAD(P) binding site [chemical binding]; other site 477641010294 active site 477641010295 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 477641010296 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 477641010297 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 477641010298 catalytic triad [active] 477641010299 putative active site [active] 477641010300 IPT/TIG domain; Region: TIG; pfam01833 477641010301 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 477641010302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641010303 acyl-activating enzyme (AAE) consensus motif; other site 477641010304 AMP binding site [chemical binding]; other site 477641010305 active site 477641010306 CoA binding site [chemical binding]; other site 477641010307 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 477641010308 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 477641010309 generic binding surface I; other site 477641010310 generic binding surface II; other site 477641010311 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 477641010312 putative active site [active] 477641010313 putative catalytic site [active] 477641010314 putative Mg binding site IVb [ion binding]; other site 477641010315 putative phosphate binding site [ion binding]; other site 477641010316 putative DNA binding site [nucleotide binding]; other site 477641010317 putative Mg binding site IVa [ion binding]; other site 477641010318 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 477641010319 SnoaL-like domain; Region: SnoaL_3; pfam13474 477641010320 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 477641010321 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 477641010322 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 477641010323 putative dimer interface [polypeptide binding]; other site 477641010324 N-terminal domain interface [polypeptide binding]; other site 477641010325 putative substrate binding pocket (H-site) [chemical binding]; other site 477641010326 EthD domain; Region: EthD; cl17553 477641010327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641010328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641010329 active site 477641010330 phosphorylation site [posttranslational modification] 477641010331 intermolecular recognition site; other site 477641010332 dimerization interface [polypeptide binding]; other site 477641010333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641010334 DNA binding residues [nucleotide binding] 477641010335 dimerization interface [polypeptide binding]; other site 477641010336 Histidine kinase; Region: HisKA_3; pfam07730 477641010337 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 477641010338 Mg2+ binding site [ion binding]; other site 477641010339 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 477641010340 Transport protein; Region: actII; TIGR00833 477641010341 TIGR03086 family protein; Region: TIGR03086 477641010342 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641010343 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 477641010344 Alkaline phosphatase homologues; Region: alkPPc; smart00098 477641010345 active site 477641010346 dimer interface [polypeptide binding]; other site 477641010347 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641010348 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 477641010349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641010350 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 477641010351 putative active site pocket [active] 477641010352 dimerization interface [polypeptide binding]; other site 477641010353 putative catalytic residue [active] 477641010354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641010355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641010356 active site 477641010357 short chain dehydrogenase; Provisional; Region: PRK06180 477641010358 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 477641010359 NADP binding site [chemical binding]; other site 477641010360 active site 477641010361 steroid binding site; other site 477641010362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641010363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641010364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641010365 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 477641010366 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 477641010367 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 477641010368 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 477641010369 Part of AAA domain; Region: AAA_19; pfam13245 477641010370 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 477641010371 putative active site [active] 477641010372 PAS domain; Region: PAS_9; pfam13426 477641010373 GAF domain; Region: GAF; cl17456 477641010374 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641010375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641010376 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641010377 Cytochrome P450; Region: p450; cl12078 477641010378 SIR2-like domain; Region: SIR2_2; pfam13289 477641010379 Evidence 4 : Homologs of previously reported genes of unknown function 477641010380 Evidence 4 : Homologs of previously reported genes of unknown function 477641010381 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 477641010382 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 477641010383 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 477641010384 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 477641010385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 477641010386 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641010387 substrate binding pocket [chemical binding]; other site 477641010388 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641010389 anti sigma factor interaction site; other site 477641010390 regulatory phosphorylation site [posttranslational modification]; other site 477641010391 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 477641010392 substrate binding site [chemical binding]; other site 477641010393 THF binding site; other site 477641010394 zinc-binding site [ion binding]; other site 477641010395 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 477641010396 Tannase and feruloyl esterase; Region: Tannase; pfam07519 477641010397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641010398 PAS domain; Region: PAS_9; pfam13426 477641010399 putative active site [active] 477641010400 heme pocket [chemical binding]; other site 477641010401 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641010402 GAF domain; Region: GAF; pfam01590 477641010403 GAF domain; Region: GAF_2; pfam13185 477641010404 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641010405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 477641010406 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 477641010407 NAD(P) binding site [chemical binding]; other site 477641010408 catalytic residues [active] 477641010409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641010410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641010411 putative substrate translocation pore; other site 477641010412 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 477641010413 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 477641010414 conserved cys residue [active] 477641010415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641010416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 477641010417 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641010418 ATP binding site [chemical binding]; other site 477641010419 putative Mg++ binding site [ion binding]; other site 477641010420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641010421 nucleotide binding region [chemical binding]; other site 477641010422 Evidence 4 : Homologs of previously reported genes of unknown function 477641010423 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 477641010424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641010425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641010426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 477641010427 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 477641010428 NAD(P) binding site [chemical binding]; other site 477641010429 catalytic residues [active] 477641010430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641010431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641010432 metal binding site [ion binding]; metal-binding site 477641010433 active site 477641010434 I-site; other site 477641010435 oxidoreductase; Provisional; Region: PRK12743 477641010436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010437 NAD(P) binding site [chemical binding]; other site 477641010438 active site 477641010439 HTH domain; Region: HTH_11; pfam08279 477641010440 WYL domain; Region: WYL; pfam13280 477641010441 Protein of unknown function (DUF664); Region: DUF664; pfam04978 477641010442 DinB superfamily; Region: DinB_2; pfam12867 477641010443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 477641010444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 477641010445 protein binding site [polypeptide binding]; other site 477641010446 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641010447 active site 477641010448 Protein of unknown function (DUF817); Region: DUF817; cl01520 477641010449 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 477641010450 putative hydrophobic ligand binding site [chemical binding]; other site 477641010451 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641010452 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641010453 B3/4 domain; Region: B3_4; pfam03483 477641010454 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 477641010455 GYD domain; Region: GYD; cl01743 477641010456 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 477641010457 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 477641010458 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 477641010459 active site 477641010460 dimer interface [polypeptide binding]; other site 477641010461 effector binding site; other site 477641010462 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 477641010463 TSCPD domain; Region: TSCPD; pfam12637 477641010464 ATP cone domain; Region: ATP-cone; pfam03477 477641010465 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 477641010466 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 477641010467 LexA repressor; Validated; Region: PRK00215 477641010468 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 477641010469 Catalytic site [active] 477641010470 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 477641010471 active site 477641010472 GTPases [General function prediction only]; Region: HflX; COG2262 477641010473 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 477641010474 HflX GTPase family; Region: HflX; cd01878 477641010475 G1 box; other site 477641010476 GTP/Mg2+ binding site [chemical binding]; other site 477641010477 Switch I region; other site 477641010478 G2 box; other site 477641010479 G3 box; other site 477641010480 Switch II region; other site 477641010481 G4 box; other site 477641010482 G5 box; other site 477641010483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641010484 dimerization interface [polypeptide binding]; other site 477641010485 putative DNA binding site [nucleotide binding]; other site 477641010486 putative Zn2+ binding site [ion binding]; other site 477641010487 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641010488 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 477641010489 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 477641010490 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 477641010491 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 477641010492 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 477641010493 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 477641010494 active site 477641010495 metal binding site [ion binding]; metal-binding site 477641010496 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 477641010497 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 477641010498 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 477641010499 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 477641010500 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 477641010501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641010502 FeS/SAM binding site; other site 477641010503 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 477641010504 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 477641010505 Walker A/P-loop; other site 477641010506 ATP binding site [chemical binding]; other site 477641010507 Q-loop/lid; other site 477641010508 ABC transporter signature motif; other site 477641010509 Walker B; other site 477641010510 D-loop; other site 477641010511 H-loop/switch region; other site 477641010512 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 477641010513 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 477641010514 substrate binding pocket [chemical binding]; other site 477641010515 membrane-bound complex binding site; other site 477641010516 hinge residues; other site 477641010517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010518 dimer interface [polypeptide binding]; other site 477641010519 conserved gate region; other site 477641010520 putative PBP binding loops; other site 477641010521 ABC-ATPase subunit interface; other site 477641010522 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 477641010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010524 dimer interface [polypeptide binding]; other site 477641010525 conserved gate region; other site 477641010526 putative PBP binding loops; other site 477641010527 ABC-ATPase subunit interface; other site 477641010528 recombination regulator RecX; Reviewed; Region: recX; PRK00117 477641010529 recombinase A; Provisional; Region: recA; PRK09354 477641010530 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 477641010531 hexamer interface [polypeptide binding]; other site 477641010532 Walker A motif; other site 477641010533 ATP binding site [chemical binding]; other site 477641010534 Walker B motif; other site 477641010535 Predicted transcriptional regulators [Transcription]; Region: COG1733 477641010536 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 477641010537 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641010538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641010539 NAD(P) binding site [chemical binding]; other site 477641010540 active site 477641010541 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 477641010542 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641010543 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 477641010544 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 477641010545 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 477641010546 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 477641010547 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 477641010548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641010549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641010550 active site 477641010551 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 477641010552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641010553 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 477641010554 KTSC domain; Region: KTSC; pfam13619 477641010555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641010556 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 477641010557 ATP binding site [chemical binding]; other site 477641010558 putative Mg++ binding site [ion binding]; other site 477641010559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641010560 nucleotide binding region [chemical binding]; other site 477641010561 ATP-binding site [chemical binding]; other site 477641010562 DEAD/H associated; Region: DEAD_assoc; pfam08494 477641010563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 477641010564 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 477641010565 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 477641010566 putative DNA binding site [nucleotide binding]; other site 477641010567 catalytic residue [active] 477641010568 putative H2TH interface [polypeptide binding]; other site 477641010569 putative catalytic residues [active] 477641010570 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 477641010571 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 477641010572 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 477641010573 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 477641010574 putative DNA binding site [nucleotide binding]; other site 477641010575 catalytic residue [active] 477641010576 putative H2TH interface [polypeptide binding]; other site 477641010577 putative catalytic residues [active] 477641010578 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 477641010579 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 477641010580 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 477641010581 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 477641010582 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 477641010583 active site 477641010584 dimer interface [polypeptide binding]; other site 477641010585 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 477641010586 dimer interface [polypeptide binding]; other site 477641010587 active site 477641010588 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 477641010589 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 477641010590 Walker A/P-loop; other site 477641010591 ATP binding site [chemical binding]; other site 477641010592 Q-loop/lid; other site 477641010593 ABC transporter signature motif; other site 477641010594 Walker B; other site 477641010595 D-loop; other site 477641010596 H-loop/switch region; other site 477641010597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 477641010598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010599 dimer interface [polypeptide binding]; other site 477641010600 conserved gate region; other site 477641010601 ABC-ATPase subunit interface; other site 477641010602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641010603 dimer interface [polypeptide binding]; other site 477641010604 conserved gate region; other site 477641010605 putative PBP binding loops; other site 477641010606 ABC-ATPase subunit interface; other site 477641010607 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 477641010608 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 477641010609 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 477641010610 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 477641010611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641010612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641010613 Competence-damaged protein; Region: CinA; pfam02464 477641010614 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 477641010615 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 477641010616 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 477641010617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641010618 FeS/SAM binding site; other site 477641010619 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 477641010620 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 477641010621 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 477641010622 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 477641010623 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641010624 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 477641010625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641010626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641010627 DNA binding residues [nucleotide binding] 477641010628 Putative zinc-finger; Region: zf-HC2; pfam13490 477641010629 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 477641010630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641010631 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 477641010632 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 477641010633 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 477641010634 dimer interface [polypeptide binding]; other site 477641010635 active site 477641010636 catalytic residue [active] 477641010637 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 477641010638 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 477641010639 folate binding site [chemical binding]; other site 477641010640 NADP+ binding site [chemical binding]; other site 477641010641 thymidylate synthase; Reviewed; Region: thyA; PRK01827 477641010642 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 477641010643 dimerization interface [polypeptide binding]; other site 477641010644 active site 477641010645 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 477641010646 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 477641010647 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 477641010648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 477641010649 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 477641010650 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 477641010651 dihydrodipicolinate reductase; Provisional; Region: PRK00048 477641010652 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 477641010653 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 477641010654 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 477641010655 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 477641010656 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 477641010657 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 477641010658 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 477641010659 RNase E interface [polypeptide binding]; other site 477641010660 trimer interface [polypeptide binding]; other site 477641010661 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 477641010662 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 477641010663 RNase E interface [polypeptide binding]; other site 477641010664 trimer interface [polypeptide binding]; other site 477641010665 active site 477641010666 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 477641010667 putative nucleic acid binding region [nucleotide binding]; other site 477641010668 G-X-X-G motif; other site 477641010669 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 477641010670 RNA binding site [nucleotide binding]; other site 477641010671 domain interface; other site 477641010672 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 477641010673 16S/18S rRNA binding site [nucleotide binding]; other site 477641010674 S13e-L30e interaction site [polypeptide binding]; other site 477641010675 25S rRNA binding site [nucleotide binding]; other site 477641010676 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 477641010677 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 477641010678 active site 477641010679 Riboflavin kinase; Region: Flavokinase; pfam01687 477641010680 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 477641010681 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 477641010682 homodimer interface [polypeptide binding]; other site 477641010683 substrate-cofactor binding pocket; other site 477641010684 catalytic residue [active] 477641010685 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641010686 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 477641010687 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 477641010688 AIR carboxylase; Region: AIRC; cl00310 477641010689 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 477641010690 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 477641010691 Ligand Binding Site [chemical binding]; other site 477641010692 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 477641010693 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 477641010694 RNA binding site [nucleotide binding]; other site 477641010695 active site 477641010696 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 477641010697 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 477641010698 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 477641010699 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 477641010700 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 477641010701 Protein of unknown function (DUF503); Region: DUF503; pfam04456 477641010702 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 477641010703 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 477641010704 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 477641010705 G1 box; other site 477641010706 putative GEF interaction site [polypeptide binding]; other site 477641010707 GTP/Mg2+ binding site [chemical binding]; other site 477641010708 Switch I region; other site 477641010709 G2 box; other site 477641010710 G3 box; other site 477641010711 Switch II region; other site 477641010712 G4 box; other site 477641010713 G5 box; other site 477641010714 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 477641010715 Translation-initiation factor 2; Region: IF-2; pfam11987 477641010716 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 477641010717 Protein of unknown function (DUF448); Region: DUF448; pfam04296 477641010718 putative RNA binding cleft [nucleotide binding]; other site 477641010719 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 477641010720 NusA N-terminal domain; Region: NusA_N; pfam08529 477641010721 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 477641010722 RNA binding site [nucleotide binding]; other site 477641010723 homodimer interface [polypeptide binding]; other site 477641010724 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 477641010725 G-X-X-G motif; other site 477641010726 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 477641010727 G-X-X-G motif; other site 477641010728 ribosome maturation protein RimP; Reviewed; Region: PRK00092 477641010729 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 477641010730 putative oligomer interface [polypeptide binding]; other site 477641010731 putative RNA binding site [nucleotide binding]; other site 477641010732 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 477641010733 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 477641010734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 477641010735 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 477641010736 Predicted acetyltransferase [General function prediction only]; Region: COG3393 477641010737 Predicted acetyltransferase [General function prediction only]; Region: COG2388 477641010738 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 477641010739 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 477641010740 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 477641010741 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 477641010742 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 477641010743 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 477641010744 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 477641010745 putative substrate binding region [chemical binding]; other site 477641010746 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 477641010747 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 477641010748 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 477641010749 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 477641010750 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 477641010751 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 477641010752 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 477641010753 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 477641010754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641010755 FeS/SAM binding site; other site 477641010756 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 477641010757 Protein of unknown function (DUF952); Region: DUF952; cl01393 477641010758 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 477641010759 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 477641010760 ribosome recycling factor; Reviewed; Region: frr; PRK00083 477641010761 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 477641010762 hinge region; other site 477641010763 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 477641010764 putative nucleotide binding site [chemical binding]; other site 477641010765 uridine monophosphate binding site [chemical binding]; other site 477641010766 homohexameric interface [polypeptide binding]; other site 477641010767 elongation factor Ts; Provisional; Region: tsf; PRK09377 477641010768 UBA/TS-N domain; Region: UBA; pfam00627 477641010769 Elongation factor TS; Region: EF_TS; pfam00889 477641010770 Elongation factor TS; Region: EF_TS; pfam00889 477641010771 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 477641010772 rRNA interaction site [nucleotide binding]; other site 477641010773 S8 interaction site; other site 477641010774 putative laminin-1 binding site; other site 477641010775 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641010776 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 477641010777 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 477641010778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641010779 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 477641010780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641010781 DNA binding residues [nucleotide binding] 477641010782 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 477641010783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641010784 active site 477641010785 DNA binding site [nucleotide binding] 477641010786 Int/Topo IB signature motif; other site 477641010787 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 477641010788 homotrimer interaction site [polypeptide binding]; other site 477641010789 putative active site [active] 477641010790 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 477641010791 DNA protecting protein DprA; Region: dprA; TIGR00732 477641010792 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 477641010793 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 477641010794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641010795 Walker A motif; other site 477641010796 ATP binding site [chemical binding]; other site 477641010797 Walker B motif; other site 477641010798 arginine finger; other site 477641010799 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 477641010800 hypothetical protein; Reviewed; Region: PRK12497 477641010801 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 477641010802 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9888800; Product type e : enzyme 477641010803 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9888800; Product type e : enzyme 477641010804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641010805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641010806 active site 477641010807 phosphorylation site [posttranslational modification] 477641010808 intermolecular recognition site; other site 477641010809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641010810 DNA binding residues [nucleotide binding] 477641010811 dimerization interface [polypeptide binding]; other site 477641010812 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 477641010813 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 477641010814 Catalytic site [active] 477641010815 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 477641010816 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641010817 nudix motif; other site 477641010818 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 477641010819 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 477641010820 RimM N-terminal domain; Region: RimM; pfam01782 477641010821 PRC-barrel domain; Region: PRC; pfam05239 477641010822 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 477641010823 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 477641010824 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 477641010825 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 477641010826 prolyl-tRNA synthetase; Provisional; Region: PRK09194 477641010827 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 477641010828 motif 1; other site 477641010829 dimer interface [polypeptide binding]; other site 477641010830 active site 477641010831 motif 2; other site 477641010832 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 477641010833 putative deacylase active site [active] 477641010834 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 477641010835 active site 477641010836 motif 3; other site 477641010837 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 477641010838 anticodon binding site; other site 477641010839 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 477641010840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641010841 active site 477641010842 signal recognition particle protein; Provisional; Region: PRK10867 477641010843 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 477641010844 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 477641010845 P loop; other site 477641010846 GTP binding site [chemical binding]; other site 477641010847 Signal peptide binding domain; Region: SRP_SPB; pfam02978 477641010848 PII uridylyl-transferase; Provisional; Region: PRK03381 477641010849 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 477641010850 metal binding triad; other site 477641010851 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 477641010852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 477641010853 Zn2+ binding site [ion binding]; other site 477641010854 Mg2+ binding site [ion binding]; other site 477641010855 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641010856 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 477641010857 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 477641010858 Nitrogen regulatory protein P-II; Region: P-II; smart00938 477641010859 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 477641010860 High-affinity nickel-transport protein; Region: NicO; cl00964 477641010861 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 477641010862 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 477641010863 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641010864 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 477641010865 putative active site [active] 477641010866 putative metal binding site [ion binding]; other site 477641010867 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 477641010868 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 477641010869 putative catalytic site [active] 477641010870 putative metal binding site [ion binding]; other site 477641010871 putative phosphate binding site [ion binding]; other site 477641010872 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 477641010873 AAA domain; Region: AAA_23; pfam13476 477641010874 Walker A/P-loop; other site 477641010875 ATP binding site [chemical binding]; other site 477641010876 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 477641010877 ABC transporter signature motif; other site 477641010878 Walker B; other site 477641010879 D-loop; other site 477641010880 H-loop/switch region; other site 477641010881 Acylphosphatase; Region: Acylphosphatase; cl00551 477641010882 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 477641010883 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 477641010884 DNA binding site [nucleotide binding] 477641010885 catalytic residue [active] 477641010886 H2TH interface [polypeptide binding]; other site 477641010887 putative catalytic residues [active] 477641010888 turnover-facilitating residue; other site 477641010889 intercalation triad [nucleotide binding]; other site 477641010890 8OG recognition residue [nucleotide binding]; other site 477641010891 putative reading head residues; other site 477641010892 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 477641010893 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 477641010894 ribonuclease III; Reviewed; Region: rnc; PRK00102 477641010895 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 477641010896 dimerization interface [polypeptide binding]; other site 477641010897 active site 477641010898 metal binding site [ion binding]; metal-binding site 477641010899 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 477641010900 dsRNA binding site [nucleotide binding]; other site 477641010901 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 477641010902 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 477641010903 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 477641010904 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 477641010905 active site 477641010906 (T/H)XGH motif; other site 477641010907 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 477641010908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641010909 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 477641010910 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 477641010911 generic binding surface II; other site 477641010912 ssDNA binding site; other site 477641010913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641010914 ATP binding site [chemical binding]; other site 477641010915 putative Mg++ binding site [ion binding]; other site 477641010916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641010917 nucleotide binding region [chemical binding]; other site 477641010918 ATP-binding site [chemical binding]; other site 477641010919 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 477641010920 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 477641010921 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 477641010922 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 477641010923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 477641010924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641010925 Coenzyme A binding pocket [chemical binding]; other site 477641010926 thiamine monophosphate kinase; Provisional; Region: PRK05731 477641010927 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 477641010928 ATP binding site [chemical binding]; other site 477641010929 dimerization interface [polypeptide binding]; other site 477641010930 AsnC family; Region: AsnC_trans_reg; pfam01037 477641010931 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 477641010932 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 477641010933 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 477641010934 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641010935 cystathionine gamma-lyase; Validated; Region: PRK07582 477641010936 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641010937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641010938 catalytic residue [active] 477641010939 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 477641010940 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 477641010941 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 477641010942 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641010943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 477641010944 putative acyl-acceptor binding pocket; other site 477641010945 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641010946 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641010947 Guanylyl transferase CofC like; Region: CofC; cl17472 477641010948 polyphosphate kinase; Provisional; Region: PRK05443 477641010949 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 477641010950 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 477641010951 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 477641010952 putative domain interface [polypeptide binding]; other site 477641010953 putative active site [active] 477641010954 catalytic site [active] 477641010955 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 477641010956 putative domain interface [polypeptide binding]; other site 477641010957 putative active site [active] 477641010958 catalytic site [active] 477641010959 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 477641010960 active site 477641010961 Ap6A binding site [chemical binding]; other site 477641010962 nudix motif; other site 477641010963 metal binding site [ion binding]; metal-binding site 477641010964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641010965 catalytic core [active] 477641010966 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 477641010967 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641010968 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 477641010969 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 477641010970 substrate binding site [chemical binding]; other site 477641010971 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 477641010972 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 477641010973 substrate binding site [chemical binding]; other site 477641010974 ligand binding site [chemical binding]; other site 477641010975 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641010976 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641010977 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641010978 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 477641010979 Na binding site [ion binding]; other site 477641010980 CAAX protease self-immunity; Region: Abi; pfam02517 477641010981 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 477641010982 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 477641010983 active site 477641010984 HIGH motif; other site 477641010985 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 477641010986 active site 477641010987 KMSKS motif; other site 477641010988 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 477641010989 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 477641010990 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 477641010991 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641010992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 477641010993 active site 477641010994 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 477641010995 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 477641010996 active site 477641010997 catalytic residues [active] 477641010998 metal binding site [ion binding]; metal-binding site 477641010999 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 477641011000 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 477641011001 tartrate dehydrogenase; Region: TTC; TIGR02089 477641011002 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 477641011003 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 477641011004 putative active site [active] 477641011005 catalytic triad [active] 477641011006 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 477641011007 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 477641011008 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 477641011009 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 477641011010 ligand binding site [chemical binding]; other site 477641011011 NAD binding site [chemical binding]; other site 477641011012 dimerization interface [polypeptide binding]; other site 477641011013 catalytic site [active] 477641011014 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 477641011015 putative L-serine binding site [chemical binding]; other site 477641011016 ketol-acid reductoisomerase; Provisional; Region: PRK05479 477641011017 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 477641011018 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 477641011019 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 477641011020 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 477641011021 putative valine binding site [chemical binding]; other site 477641011022 dimer interface [polypeptide binding]; other site 477641011023 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 477641011024 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 477641011025 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 477641011026 PYR/PP interface [polypeptide binding]; other site 477641011027 dimer interface [polypeptide binding]; other site 477641011028 TPP binding site [chemical binding]; other site 477641011029 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 477641011030 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 477641011031 TPP-binding site [chemical binding]; other site 477641011032 dimer interface [polypeptide binding]; other site 477641011033 PAS domain S-box; Region: sensory_box; TIGR00229 477641011034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641011035 putative active site [active] 477641011036 heme pocket [chemical binding]; other site 477641011037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641011038 metal binding site [ion binding]; metal-binding site 477641011039 active site 477641011040 I-site; other site 477641011041 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641011042 PAS domain S-box; Region: sensory_box; TIGR00229 477641011043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641011044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641011045 metal binding site [ion binding]; metal-binding site 477641011046 active site 477641011047 I-site; other site 477641011048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641011049 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 477641011050 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 477641011051 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 477641011052 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 477641011053 putative ligand binding site [chemical binding]; other site 477641011054 putative NAD binding site [chemical binding]; other site 477641011055 catalytic site [active] 477641011056 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 477641011057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641011058 Coenzyme A binding pocket [chemical binding]; other site 477641011059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641011060 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 477641011061 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 477641011062 GatB domain; Region: GatB_Yqey; smart00845 477641011063 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641011064 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 477641011065 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 477641011066 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641011067 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 477641011068 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 477641011069 nucleotide binding pocket [chemical binding]; other site 477641011070 K-X-D-G motif; other site 477641011071 catalytic site [active] 477641011072 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 477641011073 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 477641011074 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 477641011075 Dimer interface [polypeptide binding]; other site 477641011076 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641011077 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641011078 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 477641011079 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 477641011080 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 477641011081 putative active site [active] 477641011082 putative metal binding site [ion binding]; other site 477641011083 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 477641011084 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 477641011085 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 477641011086 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 477641011087 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 477641011088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641011089 catalytic residue [active] 477641011090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641011091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641011092 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 477641011093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 477641011094 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 477641011095 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 477641011096 Ligand binding site [chemical binding]; other site 477641011097 Electron transfer flavoprotein domain; Region: ETF; pfam01012 477641011098 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 477641011099 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 477641011100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641011101 catalytic residue [active] 477641011102 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 477641011103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641011104 Walker A/P-loop; other site 477641011105 ATP binding site [chemical binding]; other site 477641011106 Q-loop/lid; other site 477641011107 ABC transporter signature motif; other site 477641011108 Walker B; other site 477641011109 D-loop; other site 477641011110 H-loop/switch region; other site 477641011111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641011112 ABC-ATPase subunit interface; other site 477641011113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 477641011114 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 477641011115 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 477641011116 enoyl-CoA hydratase; Provisional; Region: PRK08138 477641011117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641011118 substrate binding site [chemical binding]; other site 477641011119 oxyanion hole (OAH) forming residues; other site 477641011120 trimer interface [polypeptide binding]; other site 477641011121 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 477641011122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641011123 Walker A/P-loop; other site 477641011124 ATP binding site [chemical binding]; other site 477641011125 Q-loop/lid; other site 477641011126 ABC transporter signature motif; other site 477641011127 Walker B; other site 477641011128 D-loop; other site 477641011129 H-loop/switch region; other site 477641011130 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 477641011131 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 477641011132 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 477641011133 active site 477641011134 catalytic site [active] 477641011135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 477641011136 phosphopeptide binding site; other site 477641011137 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 477641011138 putative homodimer interface [polypeptide binding]; other site 477641011139 putative active site pocket [active] 477641011140 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 477641011141 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 477641011142 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 477641011143 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 477641011144 active site 477641011145 homodimer interface [polypeptide binding]; other site 477641011146 catalytic site [active] 477641011147 acceptor binding site [chemical binding]; other site 477641011148 trehalose synthase; Region: treS_nterm; TIGR02456 477641011149 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 477641011150 active site 477641011151 catalytic site [active] 477641011152 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 477641011153 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 477641011154 glycogen branching enzyme; Provisional; Region: PRK05402 477641011155 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 477641011156 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 477641011157 active site 477641011158 catalytic site [active] 477641011159 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 477641011160 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 477641011161 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 477641011162 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 477641011163 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 477641011164 hydroxyglutarate oxidase; Provisional; Region: PRK11728 477641011165 putative acyltransferase; Provisional; Region: PRK05790 477641011166 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641011167 dimer interface [polypeptide binding]; other site 477641011168 active site 477641011169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641011170 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 477641011171 dimer interface [polypeptide binding]; other site 477641011172 substrate binding site [chemical binding]; other site 477641011173 metal binding site [ion binding]; metal-binding site 477641011174 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 477641011175 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 477641011176 active site 477641011177 putative catalytic site [active] 477641011178 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 477641011179 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 477641011180 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 477641011181 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 477641011182 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 477641011183 hypothetical protein; Provisional; Region: PRK03298 477641011184 enoyl-CoA hydratase; Validated; Region: PRK08139 477641011185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641011186 substrate binding site [chemical binding]; other site 477641011187 oxyanion hole (OAH) forming residues; other site 477641011188 trimer interface [polypeptide binding]; other site 477641011189 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 477641011190 GAF domain; Region: GAF; pfam01590 477641011191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641011192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 477641011193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641011194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 477641011195 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 477641011196 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 477641011197 active site 477641011198 hinge; other site 477641011199 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 477641011200 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 477641011201 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 477641011202 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 477641011203 gamma subunit interface [polypeptide binding]; other site 477641011204 epsilon subunit interface [polypeptide binding]; other site 477641011205 LBP interface [polypeptide binding]; other site 477641011206 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 477641011207 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 477641011208 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 477641011209 alpha subunit interaction interface [polypeptide binding]; other site 477641011210 Walker A motif; other site 477641011211 ATP binding site [chemical binding]; other site 477641011212 Walker B motif; other site 477641011213 inhibitor binding site; inhibition site 477641011214 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 477641011215 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 477641011216 core domain interface [polypeptide binding]; other site 477641011217 delta subunit interface [polypeptide binding]; other site 477641011218 epsilon subunit interface [polypeptide binding]; other site 477641011219 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 477641011220 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 477641011221 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 477641011222 beta subunit interaction interface [polypeptide binding]; other site 477641011223 Walker A motif; other site 477641011224 ATP binding site [chemical binding]; other site 477641011225 Walker B motif; other site 477641011226 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 477641011227 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 477641011228 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 477641011229 ATP synthase subunit C; Region: ATP-synt_C; cl00466 477641011230 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 477641011231 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 477641011232 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 477641011233 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 477641011234 Mg++ binding site [ion binding]; other site 477641011235 putative catalytic motif [active] 477641011236 substrate binding site [chemical binding]; other site 477641011237 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 477641011238 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 477641011239 dimer interface [polypeptide binding]; other site 477641011240 active site 477641011241 glycine-pyridoxal phosphate binding site [chemical binding]; other site 477641011242 folate binding site [chemical binding]; other site 477641011243 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 477641011244 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 477641011245 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 477641011246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641011247 S-adenosylmethionine binding site [chemical binding]; other site 477641011248 This domain is found in peptide chain release factors; Region: PCRF; smart00937 477641011249 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 477641011250 RF-1 domain; Region: RF-1; pfam00472 477641011251 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 477641011252 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 477641011253 transcription termination factor Rho; Provisional; Region: PRK12608 477641011254 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 477641011255 RNA binding site [nucleotide binding]; other site 477641011256 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641011257 Walker A motif; other site 477641011258 ATP binding site [chemical binding]; other site 477641011259 Walker B motif; other site 477641011260 homoserine kinase; Provisional; Region: PRK01212 477641011261 threonine synthase; Reviewed; Region: PRK06721 477641011262 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 477641011263 homodimer interface [polypeptide binding]; other site 477641011264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641011265 catalytic residue [active] 477641011266 homoserine dehydrogenase; Provisional; Region: PRK06349 477641011267 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 477641011268 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 477641011269 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 477641011270 diaminopimelate decarboxylase; Region: lysA; TIGR01048 477641011271 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 477641011272 active site 477641011273 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 477641011274 substrate binding site [chemical binding]; other site 477641011275 catalytic residues [active] 477641011276 dimer interface [polypeptide binding]; other site 477641011277 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 477641011278 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 477641011279 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 477641011280 active site 477641011281 HIGH motif; other site 477641011282 KMSK motif region; other site 477641011283 tRNA binding surface [nucleotide binding]; other site 477641011284 DALR anticodon binding domain; Region: DALR_1; smart00836 477641011285 anticodon binding site; other site 477641011286 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 477641011287 Domain of unknown function (DUF305); Region: DUF305; pfam03713 477641011288 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 477641011289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641011290 Walker A/P-loop; other site 477641011291 ATP binding site [chemical binding]; other site 477641011292 Q-loop/lid; other site 477641011293 ABC transporter signature motif; other site 477641011294 Walker B; other site 477641011295 D-loop; other site 477641011296 H-loop/switch region; other site 477641011297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 477641011298 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 477641011299 cyclase homology domain; Region: CHD; cd07302 477641011300 nucleotidyl binding site; other site 477641011301 metal binding site [ion binding]; metal-binding site 477641011302 dimer interface [polypeptide binding]; other site 477641011303 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641011304 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 477641011305 Walker A/P-loop; other site 477641011306 ATP binding site [chemical binding]; other site 477641011307 Q-loop/lid; other site 477641011308 ABC transporter signature motif; other site 477641011309 Walker B; other site 477641011310 D-loop; other site 477641011311 H-loop/switch region; other site 477641011312 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 477641011313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 477641011314 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 477641011315 TPP-binding site [chemical binding]; other site 477641011316 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 477641011317 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 477641011318 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 477641011319 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 477641011320 dimerization interface [polypeptide binding]; other site 477641011321 ligand binding site [chemical binding]; other site 477641011322 NADP binding site [chemical binding]; other site 477641011323 catalytic site [active] 477641011324 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 477641011325 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641011326 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 477641011327 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 477641011328 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 477641011329 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 477641011330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641011331 Coenzyme A binding pocket [chemical binding]; other site 477641011332 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 477641011333 UMP phosphatase; Provisional; Region: PRK10444 477641011334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641011335 motif II; other site 477641011336 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 477641011337 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 477641011338 Transcription factor WhiB; Region: Whib; pfam02467 477641011339 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 477641011340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 477641011341 Histidine kinase; Region: HisKA_2; pfam07568 477641011342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641011343 ATP binding site [chemical binding]; other site 477641011344 Mg2+ binding site [ion binding]; other site 477641011345 G-X-G motif; other site 477641011346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641011347 Coenzyme A binding pocket [chemical binding]; other site 477641011348 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641011349 carboxyltransferase (CT) interaction site; other site 477641011350 biotinylation site [posttranslational modification]; other site 477641011351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641011352 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 477641011353 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 477641011354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641011355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641011356 DNA binding residues [nucleotide binding] 477641011357 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 477641011358 putative deacylase active site [active] 477641011359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641011360 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641011361 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 477641011362 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 477641011363 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 477641011364 NAD(P) binding site [chemical binding]; other site 477641011365 catalytic residues [active] 477641011366 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 477641011367 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 477641011368 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 477641011369 hinge; other site 477641011370 active site 477641011371 Predicted GTPases [General function prediction only]; Region: COG1162 477641011372 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 477641011373 GTPase/Zn-binding domain interface [polypeptide binding]; other site 477641011374 GTP/Mg2+ binding site [chemical binding]; other site 477641011375 G4 box; other site 477641011376 G5 box; other site 477641011377 G1 box; other site 477641011378 Switch I region; other site 477641011379 G2 box; other site 477641011380 G3 box; other site 477641011381 Switch II region; other site 477641011382 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 477641011383 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 477641011384 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 477641011385 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 477641011386 active site 477641011387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641011388 nucleotide binding site [chemical binding]; other site 477641011389 XdhC Rossmann domain; Region: XdhC_C; pfam13478 477641011390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641011391 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641011392 active site 477641011393 catalytic tetrad [active] 477641011394 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641011395 GAF domain; Region: GAF; pfam01590 477641011396 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641011397 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 477641011398 active site 477641011399 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 477641011400 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 477641011401 dimer interface [polypeptide binding]; other site 477641011402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641011403 catalytic residue [active] 477641011404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 477641011405 cystathionine gamma-synthase; Provisional; Region: PRK07811 477641011406 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 477641011407 homodimer interface [polypeptide binding]; other site 477641011408 substrate-cofactor binding pocket; other site 477641011409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641011410 catalytic residue [active] 477641011411 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 477641011412 active site 477641011413 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641011414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641011415 sequence-specific DNA binding site [nucleotide binding]; other site 477641011416 salt bridge; other site 477641011417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011418 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641011419 active site 477641011420 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 477641011421 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 477641011422 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641011423 Cytochrome P450; Region: p450; cl12078 477641011424 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 477641011425 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 477641011426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641011427 Zn binding site [ion binding]; other site 477641011428 Predicted acetyltransferase [General function prediction only]; Region: COG2388 477641011429 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 477641011430 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 477641011431 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 477641011432 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 477641011433 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 477641011434 nucleotide binding site/active site [active] 477641011435 HIT family signature motif; other site 477641011436 catalytic residue [active] 477641011437 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 477641011438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641011439 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641011440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641011441 ATP binding site [chemical binding]; other site 477641011442 putative Mg++ binding site [ion binding]; other site 477641011443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641011444 nucleotide binding region [chemical binding]; other site 477641011445 ATP-binding site [chemical binding]; other site 477641011446 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 477641011447 hypothetical protein; Validated; Region: PRK00068 477641011448 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 477641011449 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 477641011450 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 477641011451 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 477641011452 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 477641011453 Protein of unknown function DUF45; Region: DUF45; cl00636 477641011454 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 477641011455 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 477641011456 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 477641011457 ABC1 family; Region: ABC1; cl17513 477641011458 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 477641011459 active site 477641011460 ATP binding site [chemical binding]; other site 477641011461 Transcription factor WhiB; Region: Whib; pfam02467 477641011462 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 477641011463 Part of AAA domain; Region: AAA_19; pfam13245 477641011464 Family description; Region: UvrD_C_2; pfam13538 477641011465 HRDC domain; Region: HRDC; pfam00570 477641011466 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 477641011467 catalytic residues [active] 477641011468 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 477641011469 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 477641011470 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 477641011471 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 477641011472 putative NADH binding site [chemical binding]; other site 477641011473 putative active site [active] 477641011474 nudix motif; other site 477641011475 putative metal binding site [ion binding]; other site 477641011476 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 477641011477 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 477641011478 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 477641011479 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 477641011480 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 477641011481 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 477641011482 hypothetical protein; Provisional; Region: PRK08201 477641011483 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 477641011484 metal binding site [ion binding]; metal-binding site 477641011485 putative dimer interface [polypeptide binding]; other site 477641011486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641011487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641011488 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 477641011489 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 477641011490 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 477641011491 Part of AAA domain; Region: AAA_19; pfam13245 477641011492 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 477641011493 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641011494 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 477641011495 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 477641011496 active site 477641011497 DNA binding site [nucleotide binding] 477641011498 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 477641011499 TIGR03086 family protein; Region: TIGR03086 477641011500 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 477641011501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 477641011502 ATP binding site [chemical binding]; other site 477641011503 substrate interface [chemical binding]; other site 477641011504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 477641011505 active site residue [active] 477641011506 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 477641011507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641011508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641011509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641011510 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 477641011511 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 477641011512 dinuclear metal binding motif [ion binding]; other site 477641011513 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 477641011514 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641011515 ATP binding site [chemical binding]; other site 477641011516 Mg++ binding site [ion binding]; other site 477641011517 motif III; other site 477641011518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641011519 nucleotide binding region [chemical binding]; other site 477641011520 ATP-binding site [chemical binding]; other site 477641011521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641011522 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 477641011523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641011524 transcriptional regulator, ArgP family; Region: argP; TIGR03298 477641011525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 477641011526 dimerization interface [polypeptide binding]; other site 477641011527 Lysine efflux permease [General function prediction only]; Region: COG1279 477641011528 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641011529 active site 477641011530 metal binding site [ion binding]; metal-binding site 477641011531 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 477641011532 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 477641011533 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 477641011534 active site 477641011535 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 477641011536 Bacterial PH domain; Region: DUF304; pfam03703 477641011537 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 477641011538 nudix motif; other site 477641011539 Proteins of 100 residues with WXG; Region: WXG100; cl02005 477641011540 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 477641011541 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 477641011542 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 477641011543 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 477641011544 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 477641011545 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 477641011546 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 477641011547 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 477641011548 Helix-turn-helix domain; Region: HTH_17; pfam12728 477641011549 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 477641011550 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 477641011551 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 477641011552 SEC-C motif; Region: SEC-C; pfam02810 477641011553 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 477641011554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 477641011555 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 477641011556 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 477641011557 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 477641011558 30S subunit binding site; other site 477641011559 lipoprotein LpqB; Provisional; Region: PRK13613 477641011560 Sporulation and spore germination; Region: Germane; pfam10646 477641011561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641011562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641011563 dimerization interface [polypeptide binding]; other site 477641011564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641011565 dimer interface [polypeptide binding]; other site 477641011566 phosphorylation site [posttranslational modification] 477641011567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641011568 ATP binding site [chemical binding]; other site 477641011569 Mg2+ binding site [ion binding]; other site 477641011570 G-X-G motif; other site 477641011571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641011572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641011573 active site 477641011574 phosphorylation site [posttranslational modification] 477641011575 intermolecular recognition site; other site 477641011576 dimerization interface [polypeptide binding]; other site 477641011577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641011578 DNA binding site [nucleotide binding] 477641011579 Adenosylhomocysteinase; Provisional; Region: PTZ00075 477641011580 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 477641011581 homotetramer interface [polypeptide binding]; other site 477641011582 ligand binding site [chemical binding]; other site 477641011583 catalytic site [active] 477641011584 NAD binding site [chemical binding]; other site 477641011585 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 477641011586 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 477641011587 potential frameshift: common BLAST hit: gi|386846014|ref|YP_006264027.1| Zinc transporter 9 477641011588 Cation efflux family; Region: Cation_efflux; cl00316 477641011589 Cation efflux family; Region: Cation_efflux; pfam01545 477641011590 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 477641011591 Uncharacterized conserved protein [Function unknown]; Region: COG2835 477641011592 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 477641011593 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 477641011594 active site 477641011595 substrate binding site [chemical binding]; other site 477641011596 metal binding site [ion binding]; metal-binding site 477641011597 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 477641011598 short chain dehydrogenase; Provisional; Region: PRK08251 477641011599 classical (c) SDRs; Region: SDR_c; cd05233 477641011600 NAD(P) binding site [chemical binding]; other site 477641011601 active site 477641011602 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 477641011603 Transcription factor WhiB; Region: Whib; pfam02467 477641011604 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 477641011605 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 477641011606 phosphate binding site [ion binding]; other site 477641011607 dimer interface [polypeptide binding]; other site 477641011608 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 477641011609 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 477641011610 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 477641011611 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 477641011612 NADP binding site [chemical binding]; other site 477641011613 active site 477641011614 putative substrate binding site [chemical binding]; other site 477641011615 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 477641011616 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 477641011617 NAD binding site [chemical binding]; other site 477641011618 substrate binding site [chemical binding]; other site 477641011619 homodimer interface [polypeptide binding]; other site 477641011620 active site 477641011621 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 477641011622 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 477641011623 substrate binding site; other site 477641011624 tetramer interface; other site 477641011625 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 477641011626 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 477641011627 helix-hairpin-helix signature motif; other site 477641011628 active site 477641011629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641011630 NAD(P) binding site [chemical binding]; other site 477641011631 active site 477641011632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011633 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 477641011634 active site 477641011635 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641011636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011637 active site 477641011638 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011639 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 477641011640 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 477641011641 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 477641011642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641011643 UDP-galactopyranose mutase; Region: GLF; pfam03275 477641011644 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641011645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011646 active site 477641011647 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011648 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 477641011649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 477641011650 active site 477641011651 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 477641011652 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 477641011653 Walker A/P-loop; other site 477641011654 ATP binding site [chemical binding]; other site 477641011655 Q-loop/lid; other site 477641011656 ABC transporter signature motif; other site 477641011657 Walker B; other site 477641011658 D-loop; other site 477641011659 H-loop/switch region; other site 477641011660 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 477641011661 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 477641011662 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 477641011663 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 477641011664 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641011665 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 477641011666 amidase catalytic site [active] 477641011667 Zn binding residues [ion binding]; other site 477641011668 substrate binding site [chemical binding]; other site 477641011669 LGFP repeat; Region: LGFP; pfam08310 477641011670 LGFP repeat; Region: LGFP; pfam08310 477641011671 LGFP repeat; Region: LGFP; pfam08310 477641011672 LGFP repeat; Region: LGFP; pfam08310 477641011673 LGFP repeat; Region: LGFP; pfam08310 477641011674 LGFP repeat; Region: LGFP; pfam08310 477641011675 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 477641011676 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 477641011677 LicD family; Region: LicD; cl01378 477641011678 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 477641011679 classical (c) SDRs; Region: SDR_c; cd05233 477641011680 NAD(P) binding site [chemical binding]; other site 477641011681 active site 477641011682 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641011683 FAD binding domain; Region: FAD_binding_4; pfam01565 477641011684 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 477641011685 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 477641011686 TIGR03089 family protein; Region: TIGR03089 477641011687 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 477641011688 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 477641011689 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 477641011690 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 477641011691 active site 477641011692 catalytic triad [active] 477641011693 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641011694 LGFP repeat; Region: LGFP; pfam08310 477641011695 LGFP repeat; Region: LGFP; pfam08310 477641011696 LGFP repeat; Region: LGFP; pfam08310 477641011697 LGFP repeat; Region: LGFP; pfam08310 477641011698 LGFP repeat; Region: LGFP; pfam08310 477641011699 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641011700 LGFP repeat; Region: LGFP; pfam08310 477641011701 LGFP repeat; Region: LGFP; pfam08310 477641011702 LGFP repeat; Region: LGFP; pfam08310 477641011703 LGFP repeat; Region: LGFP; pfam08310 477641011704 LGFP repeat; Region: LGFP; pfam08310 477641011705 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 477641011706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641011707 putative substrate translocation pore; other site 477641011708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641011709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641011710 active site 477641011711 catalytic tetrad [active] 477641011712 Major royal jelly protein; Region: MRJP; pfam03022 477641011713 RibD C-terminal domain; Region: RibD_C; cl17279 477641011714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641011715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641011716 active site 477641011717 AIR carboxylase; Region: AIRC; pfam00731 477641011718 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 477641011719 ATP-grasp domain; Region: ATP-grasp; pfam02222 477641011720 Predicted membrane protein [Function unknown]; Region: COG2246 477641011721 GtrA-like protein; Region: GtrA; pfam04138 477641011722 potential frameshift: common BLAST hit: gi|379737492|ref|YP_005330998.1| putative ATP-dependent dsDNA exonuclease 477641011723 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 477641011724 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 477641011725 ABC transporter signature motif; other site 477641011726 Walker B; other site 477641011727 D-loop; other site 477641011728 H-loop/switch region; other site 477641011729 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 477641011730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641011731 Walker A/P-loop; other site 477641011732 ATP binding site [chemical binding]; other site 477641011733 Q-loop/lid; other site 477641011734 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 477641011735 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 477641011736 active site 477641011737 metal binding site [ion binding]; metal-binding site 477641011738 DNA binding site [nucleotide binding] 477641011739 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 477641011740 Bacterial PH domain; Region: DUF304; pfam03703 477641011741 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 477641011742 Helix-turn-helix domain; Region: HTH_38; pfam13936 477641011743 Homeodomain-like domain; Region: HTH_32; pfam13565 477641011744 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 477641011745 Integrase core domain; Region: rve; pfam00665 477641011746 RibD C-terminal domain; Region: RibD_C; cl17279 477641011747 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 477641011748 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 477641011749 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 477641011750 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 477641011751 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 477641011752 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 477641011753 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 477641011754 Maf-like protein; Region: Maf; pfam02545 477641011755 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 477641011756 active site 477641011757 dimer interface [polypeptide binding]; other site 477641011758 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 477641011759 LGFP repeat; Region: LGFP; pfam08310 477641011760 LGFP repeat; Region: LGFP; pfam08310 477641011761 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641011762 LGFP repeat; Region: LGFP; pfam08310 477641011763 LGFP repeat; Region: LGFP; pfam08310 477641011764 LGFP repeat; Region: LGFP; pfam08310 477641011765 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 477641011766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641011767 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 477641011768 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 477641011769 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641011770 carboxyltransferase (CT) interaction site; other site 477641011771 biotinylation site [posttranslational modification]; other site 477641011772 LGFP repeat; Region: LGFP; pfam08310 477641011773 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 477641011774 LGFP repeat; Region: LGFP; pfam08310 477641011775 LGFP repeat; Region: LGFP; pfam08310 477641011776 LGFP repeat; Region: LGFP; pfam08310 477641011777 LGFP repeat; Region: LGFP; pfam08310 477641011778 LGFP repeat; Region: LGFP; pfam08310 477641011779 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 477641011780 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 477641011781 active site 477641011782 catalytic residues [active] 477641011783 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 477641011784 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 477641011785 NAD binding site [chemical binding]; other site 477641011786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641011787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 477641011788 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 477641011789 putative active site pocket [active] 477641011790 dimerization interface [polypeptide binding]; other site 477641011791 putative catalytic residue [active] 477641011792 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 477641011793 substrate binding site; other site 477641011794 dimer interface; other site 477641011795 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 477641011796 classical (c) SDRs; Region: SDR_c; cd05233 477641011797 NAD(P) binding site [chemical binding]; other site 477641011798 active site 477641011799 Predicted membrane protein [Function unknown]; Region: COG2246 477641011800 GtrA-like protein; Region: GtrA; pfam04138 477641011801 membrane ATPase/protein kinase; Provisional; Region: PRK09435 477641011802 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 477641011803 Walker A; other site 477641011804 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 477641011805 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 477641011806 active site 477641011807 substrate binding site [chemical binding]; other site 477641011808 coenzyme B12 binding site [chemical binding]; other site 477641011809 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 477641011810 B12 binding site [chemical binding]; other site 477641011811 cobalt ligand [ion binding]; other site 477641011812 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 477641011813 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 477641011814 heterodimer interface [polypeptide binding]; other site 477641011815 substrate interaction site [chemical binding]; other site 477641011816 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 477641011817 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 477641011818 metal binding site [ion binding]; metal-binding site 477641011819 putative dimer interface [polypeptide binding]; other site 477641011820 carboxylate-amine ligase; Provisional; Region: PRK13517 477641011821 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 477641011822 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 477641011823 DNA binding site [nucleotide binding] 477641011824 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 477641011825 FOG: WD40 repeat [General function prediction only]; Region: COG2319 477641011826 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 477641011827 structural tetrad; other site 477641011828 purine nucleoside phosphorylase; Provisional; Region: PRK08202 477641011829 extended (e) SDRs; Region: SDR_e; cd08946 477641011830 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641011831 NAD(P) binding site [chemical binding]; other site 477641011832 active site 477641011833 substrate binding site [chemical binding]; other site 477641011834 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 477641011835 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 477641011836 active site 477641011837 substrate binding site [chemical binding]; other site 477641011838 metal binding site [ion binding]; metal-binding site 477641011839 Phosphoglucomutase/phosphomannomutase, C-terminal domain; Region: PGM_PMM_IV; pfam00408 477641011840 Predicted membrane protein [Function unknown]; Region: COG3152 477641011841 acetylornithine deacetylase; Validated; Region: PRK06915 477641011842 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 477641011843 metal binding site [ion binding]; metal-binding site 477641011844 dimer interface [polypeptide binding]; other site 477641011845 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 477641011846 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 477641011847 AsnC family; Region: AsnC_trans_reg; pfam01037 477641011848 Protein of unknown function (DUF805); Region: DUF805; pfam05656 477641011849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 477641011850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641011851 active site 477641011852 DNA binding domain, excisionase family; Region: excise; TIGR01764 477641011853 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 477641011854 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641011855 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 477641011856 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 477641011857 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 477641011858 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 477641011859 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 477641011860 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641011861 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 477641011862 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 477641011863 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 477641011864 intersubunit interface [polypeptide binding]; other site 477641011865 active site 477641011866 catalytic residue [active] 477641011867 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 477641011868 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 477641011869 NAD(P) binding site [chemical binding]; other site 477641011870 catalytic residues [active] 477641011871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 477641011872 NAD(P) binding site [chemical binding]; other site 477641011873 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 477641011874 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641011875 ATP binding site [chemical binding]; other site 477641011876 Mg++ binding site [ion binding]; other site 477641011877 motif III; other site 477641011878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641011879 nucleotide binding region [chemical binding]; other site 477641011880 ATP-binding site [chemical binding]; other site 477641011881 adenosine deaminase; Provisional; Region: PRK09358 477641011882 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 477641011883 active site 477641011884 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641011885 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 477641011886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 477641011887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 477641011888 Walker A/P-loop; other site 477641011889 ATP binding site [chemical binding]; other site 477641011890 Q-loop/lid; other site 477641011891 ABC transporter signature motif; other site 477641011892 Walker B; other site 477641011893 D-loop; other site 477641011894 H-loop/switch region; other site 477641011895 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 477641011896 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 477641011897 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 477641011898 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 477641011899 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 477641011900 active site 477641011901 catalytic motif [active] 477641011902 Zn binding site [ion binding]; other site 477641011903 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 477641011904 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 477641011905 TM-ABC transporter signature motif; other site 477641011906 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 477641011907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641011908 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 477641011909 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 477641011910 TM-ABC transporter signature motif; other site 477641011911 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 477641011912 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641011913 Walker A/P-loop; other site 477641011914 ATP binding site [chemical binding]; other site 477641011915 Q-loop/lid; other site 477641011916 ABC transporter signature motif; other site 477641011917 Walker B; other site 477641011918 D-loop; other site 477641011919 H-loop/switch region; other site 477641011920 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641011921 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 477641011922 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 477641011923 ligand binding site [chemical binding]; other site 477641011924 Evidence 7 : Gene remnant 477641011925 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 477641011926 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 477641011927 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 477641011928 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 477641011929 active site 477641011930 HIGH motif; other site 477641011931 dimer interface [polypeptide binding]; other site 477641011932 KMSKS motif; other site 477641011933 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 477641011934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641011935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641011936 homodimer interface [polypeptide binding]; other site 477641011937 catalytic residue [active] 477641011938 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 477641011939 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 477641011940 NAD binding site [chemical binding]; other site 477641011941 homodimer interface [polypeptide binding]; other site 477641011942 active site 477641011943 substrate binding site [chemical binding]; other site 477641011944 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 477641011945 Domain of unknown function DUF21; Region: DUF21; pfam01595 477641011946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 477641011947 Transporter associated domain; Region: CorC_HlyC; smart01091 477641011948 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 477641011949 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641011950 isocitrate dehydrogenase; Validated; Region: PRK08299 477641011951 malate dehydrogenase; Reviewed; Region: PRK06223 477641011952 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 477641011953 NAD(P) binding site [chemical binding]; other site 477641011954 dimer interface [polypeptide binding]; other site 477641011955 tetramer (dimer of dimers) interface [polypeptide binding]; other site 477641011956 substrate binding site [chemical binding]; other site 477641011957 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 477641011958 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 477641011959 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 477641011960 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 477641011961 NAD(P) binding pocket [chemical binding]; other site 477641011962 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 477641011963 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 477641011964 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 477641011965 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 477641011966 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 477641011967 purine monophosphate binding site [chemical binding]; other site 477641011968 dimer interface [polypeptide binding]; other site 477641011969 putative catalytic residues [active] 477641011970 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 477641011971 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 477641011972 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 477641011973 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 477641011974 active site 477641011975 substrate binding site [chemical binding]; other site 477641011976 cosubstrate binding site; other site 477641011977 catalytic site [active] 477641011978 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 477641011979 CoA binding domain; Region: CoA_binding; smart00881 477641011980 CoA-ligase; Region: Ligase_CoA; pfam00549 477641011981 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 477641011982 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 477641011983 CoA-ligase; Region: Ligase_CoA; pfam00549 477641011984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641011985 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641011986 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641011987 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 477641011988 dimer interface [polypeptide binding]; other site 477641011989 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 477641011990 Part of AAA domain; Region: AAA_19; pfam13245 477641011991 Family description; Region: UvrD_C_2; pfam13538 477641011992 Chorismate mutase type II; Region: CM_2; cl00693 477641011993 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 477641011994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641011995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641011996 DNA binding residues [nucleotide binding] 477641011997 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 477641011998 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 477641011999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641012000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641012001 active site 477641012002 phosphorylation site [posttranslational modification] 477641012003 intermolecular recognition site; other site 477641012004 dimerization interface [polypeptide binding]; other site 477641012005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641012006 DNA binding residues [nucleotide binding] 477641012007 dimerization interface [polypeptide binding]; other site 477641012008 PspC domain; Region: PspC; pfam04024 477641012009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 477641012010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641012011 ATP binding site [chemical binding]; other site 477641012012 Mg2+ binding site [ion binding]; other site 477641012013 G-X-G motif; other site 477641012014 PspC domain; Region: PspC; pfam04024 477641012015 PspC domain; Region: PspC; pfam04024 477641012016 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 477641012017 GMP synthase; Reviewed; Region: guaA; PRK00074 477641012018 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 477641012019 AMP/PPi binding site [chemical binding]; other site 477641012020 candidate oxyanion hole; other site 477641012021 catalytic triad [active] 477641012022 potential glutamine specificity residues [chemical binding]; other site 477641012023 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 477641012024 ATP Binding subdomain [chemical binding]; other site 477641012025 Ligand Binding sites [chemical binding]; other site 477641012026 Dimerization subdomain; other site 477641012027 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 477641012028 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 477641012029 phosphate binding site [ion binding]; other site 477641012030 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 477641012031 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 477641012032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 477641012033 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 477641012034 active site 477641012035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641012036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641012037 active site 477641012038 phosphorylation site [posttranslational modification] 477641012039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 477641012040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 477641012041 DNA binding residues [nucleotide binding] 477641012042 dimerization interface [polypeptide binding]; other site 477641012043 Transcription factor WhiB; Region: Whib; pfam02467 477641012044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 477641012045 binding surface 477641012046 TPR motif; other site 477641012047 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641012048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641012049 metal binding site [ion binding]; metal-binding site 477641012050 active site 477641012051 I-site; other site 477641012052 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 477641012053 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 477641012054 ring oligomerisation interface [polypeptide binding]; other site 477641012055 ATP/Mg binding site [chemical binding]; other site 477641012056 stacking interactions; other site 477641012057 hinge regions; other site 477641012058 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 477641012059 oligomerisation interface [polypeptide binding]; other site 477641012060 mobile loop; other site 477641012061 roof hairpin; other site 477641012062 UGMP family protein; Validated; Region: PRK09604 477641012063 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 477641012064 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 477641012065 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 477641012066 Glycoprotease family; Region: Peptidase_M22; pfam00814 477641012067 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 477641012068 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 477641012069 Walker A/P-loop; other site 477641012070 ATP binding site [chemical binding]; other site 477641012071 Q-loop/lid; other site 477641012072 ABC transporter signature motif; other site 477641012073 Walker B; other site 477641012074 D-loop; other site 477641012075 H-loop/switch region; other site 477641012076 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 477641012077 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 477641012078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 477641012079 putative PBP binding regions; other site 477641012080 ABC-ATPase subunit interface; other site 477641012081 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 477641012082 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 477641012083 intersubunit interface [polypeptide binding]; other site 477641012084 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 477641012085 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 477641012086 Fe-S cluster binding site [ion binding]; other site 477641012087 active site 477641012088 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 477641012089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641012090 alanine racemase; Reviewed; Region: alr; PRK00053 477641012091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 477641012092 active site 477641012093 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 477641012094 dimer interface [polypeptide binding]; other site 477641012095 substrate binding site [chemical binding]; other site 477641012096 catalytic residues [active] 477641012097 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 477641012098 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 477641012099 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 477641012100 putative substrate binding site [chemical binding]; other site 477641012101 putative ATP binding site [chemical binding]; other site 477641012102 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 477641012103 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 477641012104 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 477641012105 glutaminase active site [active] 477641012106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 477641012107 dimer interface [polypeptide binding]; other site 477641012108 active site 477641012109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 477641012110 dimer interface [polypeptide binding]; other site 477641012111 active site 477641012112 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 477641012113 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 477641012114 active site 477641012115 substrate binding site [chemical binding]; other site 477641012116 metal binding site [ion binding]; metal-binding site 477641012117 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 477641012118 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 477641012119 23S rRNA interface [nucleotide binding]; other site 477641012120 L3 interface [polypeptide binding]; other site 477641012121 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 477641012122 active site clefts [active] 477641012123 zinc binding site [ion binding]; other site 477641012124 dimer interface [polypeptide binding]; other site 477641012125 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 477641012126 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 477641012127 dimer interface [polypeptide binding]; other site 477641012128 putative functional site; other site 477641012129 putative MPT binding site; other site 477641012130 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 477641012131 trimer interface [polypeptide binding]; other site 477641012132 dimer interface [polypeptide binding]; other site 477641012133 putative active site [active] 477641012134 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 477641012135 MPT binding site; other site 477641012136 trimer interface [polypeptide binding]; other site 477641012137 potential frameshift: common BLAST hit: gi|375141292|ref|YP_005001941.1| integrase family protein 477641012138 Integrase core domain; Region: rve; pfam00665 477641012139 Integrase core domain; Region: rve_3; pfam13683 477641012140 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 477641012141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641012142 NADH(P)-binding; Region: NAD_binding_10; pfam13460 477641012143 NAD(P) binding site [chemical binding]; other site 477641012144 active site 477641012145 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 477641012146 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 477641012147 dimerization interface 3.5A [polypeptide binding]; other site 477641012148 active site 477641012149 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 477641012150 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 477641012151 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 477641012152 alphaNTD homodimer interface [polypeptide binding]; other site 477641012153 alphaNTD - beta interaction site [polypeptide binding]; other site 477641012154 alphaNTD - beta' interaction site [polypeptide binding]; other site 477641012155 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 477641012156 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 477641012157 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 477641012158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 477641012159 RNA binding surface [nucleotide binding]; other site 477641012160 30S ribosomal protein S11; Validated; Region: PRK05309 477641012161 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 477641012162 30S ribosomal protein S13; Region: bact_S13; TIGR03631 477641012163 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 477641012164 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 477641012165 rRNA binding site [nucleotide binding]; other site 477641012166 predicted 30S ribosome binding site; other site 477641012167 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 477641012168 active site 477641012169 adenylate kinase; Reviewed; Region: adk; PRK00279 477641012170 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 477641012171 AMP-binding site [chemical binding]; other site 477641012172 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 477641012173 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 477641012174 SecY translocase; Region: SecY; pfam00344 477641012175 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 477641012176 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 477641012177 23S rRNA binding site [nucleotide binding]; other site 477641012178 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 477641012179 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 477641012180 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 477641012181 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 477641012182 5S rRNA interface [nucleotide binding]; other site 477641012183 23S rRNA interface [nucleotide binding]; other site 477641012184 L5 interface [polypeptide binding]; other site 477641012185 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 477641012186 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 477641012187 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 477641012188 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 477641012189 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 477641012190 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 477641012191 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 477641012192 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 477641012193 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 477641012194 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 477641012195 RNA binding site [nucleotide binding]; other site 477641012196 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 477641012197 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 477641012198 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 477641012199 putative translocon interaction site; other site 477641012200 23S rRNA interface [nucleotide binding]; other site 477641012201 signal recognition particle (SRP54) interaction site; other site 477641012202 L23 interface [polypeptide binding]; other site 477641012203 trigger factor interaction site; other site 477641012204 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 477641012205 23S rRNA interface [nucleotide binding]; other site 477641012206 5S rRNA interface [nucleotide binding]; other site 477641012207 putative antibiotic binding site [chemical binding]; other site 477641012208 L25 interface [polypeptide binding]; other site 477641012209 L27 interface [polypeptide binding]; other site 477641012210 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 477641012211 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 477641012212 G-X-X-G motif; other site 477641012213 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 477641012214 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 477641012215 putative translocon binding site; other site 477641012216 protein-rRNA interface [nucleotide binding]; other site 477641012217 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 477641012218 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 477641012219 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 477641012220 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 477641012221 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 477641012222 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 477641012223 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 477641012224 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 477641012225 elongation factor Tu; Reviewed; Region: PRK00049 477641012226 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 477641012227 G1 box; other site 477641012228 GEF interaction site [polypeptide binding]; other site 477641012229 GTP/Mg2+ binding site [chemical binding]; other site 477641012230 Switch I region; other site 477641012231 G2 box; other site 477641012232 G3 box; other site 477641012233 Switch II region; other site 477641012234 G4 box; other site 477641012235 G5 box; other site 477641012236 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 477641012237 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 477641012238 Antibiotic Binding Site [chemical binding]; other site 477641012239 elongation factor G; Reviewed; Region: PRK00007 477641012240 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 477641012241 G1 box; other site 477641012242 putative GEF interaction site [polypeptide binding]; other site 477641012243 GTP/Mg2+ binding site [chemical binding]; other site 477641012244 Switch I region; other site 477641012245 G2 box; other site 477641012246 G3 box; other site 477641012247 Switch II region; other site 477641012248 G4 box; other site 477641012249 G5 box; other site 477641012250 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 477641012251 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 477641012252 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 477641012253 30S ribosomal protein S7; Validated; Region: PRK05302 477641012254 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 477641012255 S17 interaction site [polypeptide binding]; other site 477641012256 S8 interaction site; other site 477641012257 16S rRNA interaction site [nucleotide binding]; other site 477641012258 streptomycin interaction site [chemical binding]; other site 477641012259 23S rRNA interaction site [nucleotide binding]; other site 477641012260 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 477641012261 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 477641012262 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641012263 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 477641012264 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 477641012265 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 477641012266 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 477641012267 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 477641012268 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 477641012269 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 477641012270 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 477641012271 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 477641012272 G-loop; other site 477641012273 DNA binding site [nucleotide binding] 477641012274 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 477641012275 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 477641012276 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 477641012277 RPB10 interaction site [polypeptide binding]; other site 477641012278 RPB1 interaction site [polypeptide binding]; other site 477641012279 RPB11 interaction site [polypeptide binding]; other site 477641012280 RPB3 interaction site [polypeptide binding]; other site 477641012281 RPB12 interaction site [polypeptide binding]; other site 477641012282 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 477641012283 core dimer interface [polypeptide binding]; other site 477641012284 peripheral dimer interface [polypeptide binding]; other site 477641012285 L10 interface [polypeptide binding]; other site 477641012286 L11 interface [polypeptide binding]; other site 477641012287 putative EF-Tu interaction site [polypeptide binding]; other site 477641012288 putative EF-G interaction site [polypeptide binding]; other site 477641012289 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 477641012290 23S rRNA interface [nucleotide binding]; other site 477641012291 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 477641012292 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 477641012293 mRNA/rRNA interface [nucleotide binding]; other site 477641012294 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 477641012295 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 477641012296 23S rRNA interface [nucleotide binding]; other site 477641012297 L7/L12 interface [polypeptide binding]; other site 477641012298 putative thiostrepton binding site; other site 477641012299 L25 interface [polypeptide binding]; other site 477641012300 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 477641012301 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 477641012302 putative homodimer interface [polypeptide binding]; other site 477641012303 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 477641012304 heterodimer interface [polypeptide binding]; other site 477641012305 homodimer interface [polypeptide binding]; other site 477641012306 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 477641012307 aspartate aminotransferase; Provisional; Region: PRK05764 477641012308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641012309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641012310 homodimer interface [polypeptide binding]; other site 477641012311 catalytic residue [active] 477641012312 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 477641012313 Zn binding site [ion binding]; other site 477641012314 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 477641012315 active site 477641012316 catalytic site [active] 477641012317 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 477641012318 active site 477641012319 catalytic site [active] 477641012320 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 477641012321 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641012322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641012323 metal binding site [ion binding]; metal-binding site 477641012324 active site 477641012325 I-site; other site 477641012326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641012327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 477641012328 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 477641012329 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 477641012330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641012331 active site 477641012332 metal binding site [ion binding]; metal-binding site 477641012333 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 477641012334 active site 477641012335 catalytic triad [active] 477641012336 oxyanion hole [active] 477641012337 heat shock protein HtpX; Provisional; Region: PRK03072 477641012338 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 477641012339 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 477641012340 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 477641012341 dimer interface [polypeptide binding]; other site 477641012342 PYR/PP interface [polypeptide binding]; other site 477641012343 TPP binding site [chemical binding]; other site 477641012344 substrate binding site [chemical binding]; other site 477641012345 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 477641012346 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 477641012347 TPP-binding site [chemical binding]; other site 477641012348 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 477641012349 Cytochrome P450; Region: p450; cl12078 477641012350 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 477641012351 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 477641012352 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 477641012353 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 477641012354 substrate binding pocket [chemical binding]; other site 477641012355 chain length determination region; other site 477641012356 substrate-Mg2+ binding site; other site 477641012357 catalytic residues [active] 477641012358 aspartate-rich region 1; other site 477641012359 active site lid residues [active] 477641012360 aspartate-rich region 2; other site 477641012361 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 477641012362 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641012363 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 477641012364 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641012365 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 477641012366 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 477641012367 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 477641012368 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 477641012369 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 477641012370 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 477641012371 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 477641012372 4Fe-4S binding domain; Region: Fer4; pfam00037 477641012373 4Fe-4S binding domain; Region: Fer4; pfam00037 477641012374 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 477641012375 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 477641012376 NADH dehydrogenase subunit G; Validated; Region: PRK07860 477641012377 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641012378 catalytic loop [active] 477641012379 iron binding site [ion binding]; other site 477641012380 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 477641012381 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 477641012382 molybdopterin cofactor binding site; other site 477641012383 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 477641012384 molybdopterin cofactor binding site; other site 477641012385 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 477641012386 SLBB domain; Region: SLBB; pfam10531 477641012387 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 477641012388 NADH dehydrogenase subunit E; Validated; Region: PRK07539 477641012389 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 477641012390 putative dimer interface [polypeptide binding]; other site 477641012391 [2Fe-2S] cluster binding site [ion binding]; other site 477641012392 NADH dehydrogenase subunit D; Validated; Region: PRK06075 477641012393 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 477641012394 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 477641012395 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 477641012396 NADH dehydrogenase subunit B; Validated; Region: PRK06411 477641012397 NADH dehydrogenase subunit A; Validated; Region: PRK07928 477641012398 Transposase; Region: DEDD_Tnp_IS110; pfam01548 477641012399 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 477641012400 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 477641012401 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641012402 active site 477641012403 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 477641012404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641012405 S-adenosylmethionine binding site [chemical binding]; other site 477641012406 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 477641012407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641012408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641012409 metal binding site [ion binding]; metal-binding site 477641012410 active site 477641012411 I-site; other site 477641012412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641012413 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 477641012414 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 477641012415 dimer interface [polypeptide binding]; other site 477641012416 tetramer interface [polypeptide binding]; other site 477641012417 PYR/PP interface [polypeptide binding]; other site 477641012418 TPP binding site [chemical binding]; other site 477641012419 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 477641012420 TPP-binding site [chemical binding]; other site 477641012421 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 477641012422 O-succinylbenzoate synthase; Provisional; Region: PRK02901 477641012423 active site 477641012424 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 477641012425 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 477641012426 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641012427 active site 477641012428 CoA binding site [chemical binding]; other site 477641012429 AMP binding site [chemical binding]; other site 477641012430 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 477641012431 UbiA prenyltransferase family; Region: UbiA; pfam01040 477641012432 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 477641012433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641012434 putative DNA binding site [nucleotide binding]; other site 477641012435 putative Zn2+ binding site [ion binding]; other site 477641012436 AsnC family; Region: AsnC_trans_reg; pfam01037 477641012437 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 477641012438 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 477641012439 ResB-like family; Region: ResB; pfam05140 477641012440 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 477641012441 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 477641012442 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 477641012443 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 477641012444 catalytic residues [active] 477641012445 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641012446 catalytic core [active] 477641012447 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 477641012448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 477641012449 inhibitor-cofactor binding pocket; inhibition site 477641012450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641012451 catalytic residue [active] 477641012452 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 477641012453 dimer interface [polypeptide binding]; other site 477641012454 active site 477641012455 Schiff base residues; other site 477641012456 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 477641012457 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 477641012458 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 477641012459 active site 477641012460 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 477641012461 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 477641012462 domain interfaces; other site 477641012463 active site 477641012464 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 477641012465 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 477641012466 tRNA; other site 477641012467 putative tRNA binding site [nucleotide binding]; other site 477641012468 putative NADP binding site [chemical binding]; other site 477641012469 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 477641012470 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 477641012471 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 477641012472 CoA binding domain; Region: CoA_binding; pfam02629 477641012473 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 477641012474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641012475 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 477641012476 acyl-activating enzyme (AAE) consensus motif; other site 477641012477 AMP binding site [chemical binding]; other site 477641012478 active site 477641012479 CoA binding site [chemical binding]; other site 477641012480 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 477641012481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 477641012482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641012483 DNA binding residues [nucleotide binding] 477641012484 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 477641012485 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 477641012486 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 477641012487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 477641012488 putative acyl-acceptor binding pocket; other site 477641012489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641012490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641012491 NAD(P) binding site [chemical binding]; other site 477641012492 active site 477641012493 DNA binding domain, excisionase family; Region: excise; TIGR01764 477641012494 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 477641012495 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 477641012496 exopolyphosphatase; Region: exo_poly_only; TIGR03706 477641012497 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 477641012498 nucleotide binding site [chemical binding]; other site 477641012499 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 477641012500 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 477641012501 conserved cys residue [active] 477641012502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641012503 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 477641012504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641012505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641012506 active site 477641012507 phosphorylation site [posttranslational modification] 477641012508 intermolecular recognition site; other site 477641012509 dimerization interface [polypeptide binding]; other site 477641012510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641012511 DNA binding site [nucleotide binding] 477641012512 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 477641012513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641012514 dimer interface [polypeptide binding]; other site 477641012515 phosphorylation site [posttranslational modification] 477641012516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641012517 ATP binding site [chemical binding]; other site 477641012518 G-X-G motif; other site 477641012519 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 477641012520 PhoU domain; Region: PhoU; pfam01895 477641012521 PhoU domain; Region: PhoU; pfam01895 477641012522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641012523 catalytic core [active] 477641012524 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641012525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012527 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 477641012528 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 477641012529 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 477641012530 putative ADP-binding pocket [chemical binding]; other site 477641012531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641012532 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 477641012533 NAD(P) binding site [chemical binding]; other site 477641012534 active site 477641012535 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 477641012536 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012537 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 477641012538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 477641012539 PspC domain; Region: PspC; pfam04024 477641012540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 477641012541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 477641012542 non-specific DNA binding site [nucleotide binding]; other site 477641012543 salt bridge; other site 477641012544 sequence-specific DNA binding site [nucleotide binding]; other site 477641012545 L-asparaginase II; Region: Asparaginase_II; pfam06089 477641012546 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 477641012547 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 477641012548 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 477641012549 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 477641012550 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 477641012551 metal binding site 2 [ion binding]; metal-binding site 477641012552 putative DNA binding helix; other site 477641012553 metal binding site 1 [ion binding]; metal-binding site 477641012554 dimer interface [polypeptide binding]; other site 477641012555 structural Zn2+ binding site [ion binding]; other site 477641012556 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 477641012557 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 477641012558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641012559 catalytic residue [active] 477641012560 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 477641012561 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 477641012562 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 477641012563 heme-binding site [chemical binding]; other site 477641012564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641012565 TAP-like protein; Region: Abhydrolase_4; pfam08386 477641012566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641012567 PAS domain; Region: PAS_9; pfam13426 477641012568 putative active site [active] 477641012569 heme pocket [chemical binding]; other site 477641012570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641012571 metal binding site [ion binding]; metal-binding site 477641012572 active site 477641012573 I-site; other site 477641012574 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 477641012575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641012576 NAD(P) binding site [chemical binding]; other site 477641012577 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 477641012578 active site 477641012579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641012580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641012581 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 477641012582 cleavage site 477641012583 active site 477641012584 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 477641012585 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 477641012586 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 477641012587 active site residue [active] 477641012588 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 477641012589 active site residue [active] 477641012590 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 477641012591 catalytic residues [active] 477641012592 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 477641012593 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641012594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641012595 DNA binding site [nucleotide binding] 477641012596 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 477641012597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641012598 Coenzyme A binding pocket [chemical binding]; other site 477641012599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641012600 Coenzyme A binding pocket [chemical binding]; other site 477641012601 PBP superfamily domain; Region: PBP_like_2; cl17296 477641012602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641012603 dimer interface [polypeptide binding]; other site 477641012604 conserved gate region; other site 477641012605 ABC-ATPase subunit interface; other site 477641012606 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 477641012607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641012608 dimer interface [polypeptide binding]; other site 477641012609 conserved gate region; other site 477641012610 putative PBP binding loops; other site 477641012611 ABC-ATPase subunit interface; other site 477641012612 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 477641012613 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 477641012614 Walker A/P-loop; other site 477641012615 ATP binding site [chemical binding]; other site 477641012616 Q-loop/lid; other site 477641012617 ABC transporter signature motif; other site 477641012618 Walker B; other site 477641012619 D-loop; other site 477641012620 H-loop/switch region; other site 477641012621 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 477641012622 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 477641012623 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 477641012624 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 477641012625 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 477641012626 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 477641012627 FAD binding pocket [chemical binding]; other site 477641012628 FAD binding motif [chemical binding]; other site 477641012629 phosphate binding motif [ion binding]; other site 477641012630 NAD binding pocket [chemical binding]; other site 477641012631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641012632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641012633 active site 477641012634 phosphorylation site [posttranslational modification] 477641012635 intermolecular recognition site; other site 477641012636 dimerization interface [polypeptide binding]; other site 477641012637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641012638 DNA binding site [nucleotide binding] 477641012639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641012640 dimerization interface [polypeptide binding]; other site 477641012641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641012642 dimer interface [polypeptide binding]; other site 477641012643 phosphorylation site [posttranslational modification] 477641012644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641012645 ATP binding site [chemical binding]; other site 477641012646 Mg2+ binding site [ion binding]; other site 477641012647 G-X-G motif; other site 477641012648 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 477641012649 CoenzymeA binding site [chemical binding]; other site 477641012650 subunit interaction site [polypeptide binding]; other site 477641012651 PHB binding site; other site 477641012652 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 477641012653 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 477641012654 Active Sites [active] 477641012655 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 477641012656 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 477641012657 CysD dimerization site [polypeptide binding]; other site 477641012658 G1 box; other site 477641012659 putative GEF interaction site [polypeptide binding]; other site 477641012660 GTP/Mg2+ binding site [chemical binding]; other site 477641012661 Switch I region; other site 477641012662 G2 box; other site 477641012663 G3 box; other site 477641012664 Switch II region; other site 477641012665 G4 box; other site 477641012666 G5 box; other site 477641012667 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 477641012668 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 477641012669 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 477641012670 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012671 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 477641012672 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641012673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 477641012674 catalytic loop [active] 477641012675 iron binding site [ion binding]; other site 477641012676 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641012677 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 477641012678 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641012679 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641012680 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 477641012681 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 477641012682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641012683 ATP binding site [chemical binding]; other site 477641012684 putative Mg++ binding site [ion binding]; other site 477641012685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641012686 nucleotide binding region [chemical binding]; other site 477641012687 ATP-binding site [chemical binding]; other site 477641012688 Helicase associated domain (HA2); Region: HA2; pfam04408 477641012689 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 477641012690 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 477641012691 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641012692 MarR family; Region: MarR; pfam01047 477641012693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012694 putative substrate translocation pore; other site 477641012695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641012696 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 477641012697 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641012698 NAD binding site [chemical binding]; other site 477641012699 catalytic Zn binding site [ion binding]; other site 477641012700 structural Zn binding site [ion binding]; other site 477641012701 potential frameshift: common BLAST hit: gi|379736387|ref|YP_005329893.1| HNH endonuclease 477641012702 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641012703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641012704 active site 477641012705 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 477641012706 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 477641012707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641012708 active site 477641012709 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 477641012710 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 477641012711 enoyl-CoA hydratase; Provisional; Region: PRK05870 477641012712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641012713 substrate binding site [chemical binding]; other site 477641012714 oxyanion hole (OAH) forming residues; other site 477641012715 trimer interface [polypeptide binding]; other site 477641012716 Hemerythrin-like domain; Region: Hr-like; cd12108 477641012717 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641012718 MarR family; Region: MarR_2; pfam12802 477641012719 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 477641012720 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 477641012721 active site 477641012722 DNA binding site [nucleotide binding] 477641012723 catalytic site [active] 477641012724 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641012725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641012726 putative Zn2+ binding site [ion binding]; other site 477641012727 putative DNA binding site [nucleotide binding]; other site 477641012728 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 477641012729 acetylornithine deacetylase; Validated; Region: PRK06915 477641012730 metal binding site [ion binding]; metal-binding site 477641012731 dimer interface [polypeptide binding]; other site 477641012732 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 477641012733 iron-sulfur cluster [ion binding]; other site 477641012734 [2Fe-2S] cluster binding site [ion binding]; other site 477641012735 Predicted membrane protein [Function unknown]; Region: COG2246 477641012736 GtrA-like protein; Region: GtrA; pfam04138 477641012737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 477641012738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641012739 active site 477641012740 phosphorylation site [posttranslational modification] 477641012741 intermolecular recognition site; other site 477641012742 dimerization interface [polypeptide binding]; other site 477641012743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 477641012744 DNA binding site [nucleotide binding] 477641012745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641012746 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 477641012747 dimerization interface [polypeptide binding]; other site 477641012748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641012749 dimer interface [polypeptide binding]; other site 477641012750 phosphorylation site [posttranslational modification] 477641012751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641012752 ATP binding site [chemical binding]; other site 477641012753 Mg2+ binding site [ion binding]; other site 477641012754 G-X-G motif; other site 477641012755 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 477641012756 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 477641012757 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 477641012758 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 477641012759 tetramer interface [polypeptide binding]; other site 477641012760 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 477641012761 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 477641012762 active site 477641012763 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 477641012764 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 477641012765 active site 477641012766 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641012767 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641012768 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641012769 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 477641012770 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641012771 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 477641012772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641012773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641012774 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 477641012775 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 477641012776 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 477641012777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641012778 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 477641012779 Peptidase family M23; Region: Peptidase_M23; pfam01551 477641012780 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641012781 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641012782 Walker A/P-loop; other site 477641012783 ATP binding site [chemical binding]; other site 477641012784 Q-loop/lid; other site 477641012785 ABC transporter signature motif; other site 477641012786 Walker B; other site 477641012787 D-loop; other site 477641012788 H-loop/switch region; other site 477641012789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641012790 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641012791 TM-ABC transporter signature motif; other site 477641012792 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 477641012793 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 477641012794 putative ligand binding site [chemical binding]; other site 477641012795 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 477641012796 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 477641012797 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 477641012798 NAD binding site [chemical binding]; other site 477641012799 Phe binding site; other site 477641012800 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 477641012801 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 477641012802 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 477641012803 dimerization interface [polypeptide binding]; other site 477641012804 putative ATP binding site [chemical binding]; other site 477641012805 amidophosphoribosyltransferase; Provisional; Region: PRK07847 477641012806 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 477641012807 active site 477641012808 tetramer interface [polypeptide binding]; other site 477641012809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641012810 active site 477641012811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 477641012812 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 477641012813 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641012814 NAD binding site [chemical binding]; other site 477641012815 catalytic Zn binding site [ion binding]; other site 477641012816 substrate binding site [chemical binding]; other site 477641012817 structural Zn binding site [ion binding]; other site 477641012818 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 477641012819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012820 putative substrate translocation pore; other site 477641012821 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 477641012822 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 477641012823 dimerization interface [polypeptide binding]; other site 477641012824 ATP binding site [chemical binding]; other site 477641012825 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 477641012826 dimerization interface [polypeptide binding]; other site 477641012827 ATP binding site [chemical binding]; other site 477641012828 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 477641012829 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 477641012830 putative active site [active] 477641012831 catalytic triad [active] 477641012832 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 477641012833 PilZ domain; Region: PilZ; pfam07238 477641012834 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 477641012835 ATP binding site [chemical binding]; other site 477641012836 active site 477641012837 substrate binding site [chemical binding]; other site 477641012838 adenylosuccinate lyase; Provisional; Region: PRK07492 477641012839 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 477641012840 tetramer interface [polypeptide binding]; other site 477641012841 active site 477641012842 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 477641012843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 477641012844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641012845 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 477641012846 NAD(P) binding site [chemical binding]; other site 477641012847 active site 477641012848 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641012849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641012850 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 477641012851 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 477641012852 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 477641012853 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 477641012854 Predicted GTPases [General function prediction only]; Region: COG1162 477641012855 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 477641012856 GTPase/Zn-binding domain interface [polypeptide binding]; other site 477641012857 GTP/Mg2+ binding site [chemical binding]; other site 477641012858 G4 box; other site 477641012859 G5 box; other site 477641012860 G1 box; other site 477641012861 Switch I region; other site 477641012862 G2 box; other site 477641012863 G3 box; other site 477641012864 Switch II region; other site 477641012865 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 477641012866 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 477641012867 active site 477641012868 catalytic site [active] 477641012869 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 477641012870 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 477641012871 GDP-binding site [chemical binding]; other site 477641012872 ACT binding site; other site 477641012873 IMP binding site; other site 477641012874 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641012875 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641012876 TM-ABC transporter signature motif; other site 477641012877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 477641012878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641012879 Walker A/P-loop; other site 477641012880 ATP binding site [chemical binding]; other site 477641012881 Q-loop/lid; other site 477641012882 ABC transporter signature motif; other site 477641012883 Walker B; other site 477641012884 D-loop; other site 477641012885 H-loop/switch region; other site 477641012886 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 477641012887 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 477641012888 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 477641012889 active site 477641012890 intersubunit interface [polypeptide binding]; other site 477641012891 zinc binding site [ion binding]; other site 477641012892 Na+ binding site [ion binding]; other site 477641012893 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012894 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 477641012895 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 477641012896 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 477641012897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 477641012898 active site 477641012899 Fasciclin domain; Region: Fasciclin; pfam02469 477641012900 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 477641012901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641012902 Walker A motif; other site 477641012903 ATP binding site [chemical binding]; other site 477641012904 Walker B motif; other site 477641012905 arginine finger; other site 477641012906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641012907 Walker A motif; other site 477641012908 ATP binding site [chemical binding]; other site 477641012909 Walker B motif; other site 477641012910 arginine finger; other site 477641012911 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 477641012912 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641012913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641012914 putative Zn2+ binding site [ion binding]; other site 477641012915 putative DNA binding site [nucleotide binding]; other site 477641012916 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 477641012917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641012919 putative substrate translocation pore; other site 477641012920 MarR family; Region: MarR; pfam01047 477641012921 MarR family; Region: MarR_2; cl17246 477641012922 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641012923 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 477641012925 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 477641012926 homodimer interface [polypeptide binding]; other site 477641012927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641012928 catalytic residue [active] 477641012929 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 477641012930 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 477641012931 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 477641012932 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 477641012933 CoA-transferase family III; Region: CoA_transf_3; pfam02515 477641012934 enoyl-CoA hydratase; Provisional; Region: PRK06144 477641012935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 477641012936 substrate binding site [chemical binding]; other site 477641012937 oxyanion hole (OAH) forming residues; other site 477641012938 trimer interface [polypeptide binding]; other site 477641012939 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 477641012940 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 477641012941 Bacterial transcriptional regulator; Region: IclR; pfam01614 477641012942 malate synthase A; Region: malate_syn_A; TIGR01344 477641012943 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 477641012944 active site 477641012945 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 477641012946 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012947 FAD binding domain; Region: FAD_binding_4; pfam01565 477641012948 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 477641012949 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 477641012950 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 477641012951 Cysteine-rich domain; Region: CCG; pfam02754 477641012952 Cysteine-rich domain; Region: CCG; pfam02754 477641012953 L-lactate permease; Region: Lactate_perm; cl00701 477641012954 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 477641012955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641012956 putative Zn2+ binding site [ion binding]; other site 477641012957 putative DNA binding site [nucleotide binding]; other site 477641012958 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 477641012959 DNA binding residues [nucleotide binding] 477641012960 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641012961 putative dimer interface [polypeptide binding]; other site 477641012962 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 477641012963 HSP70 interaction site [polypeptide binding]; other site 477641012964 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 477641012965 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 477641012966 Zn binding sites [ion binding]; other site 477641012967 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 477641012968 dimer interface [polypeptide binding]; other site 477641012969 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 477641012970 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 477641012971 dimer interface [polypeptide binding]; other site 477641012972 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 477641012973 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 477641012974 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 477641012975 nucleotide binding site [chemical binding]; other site 477641012976 NEF interaction site [polypeptide binding]; other site 477641012977 SBD interface [polypeptide binding]; other site 477641012978 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 477641012979 4Fe-4S binding domain; Region: Fer4; pfam00037 477641012980 Cysteine-rich domain; Region: CCG; pfam02754 477641012981 Cysteine-rich domain; Region: CCG; pfam02754 477641012982 Domain of unknown function (DUF389); Region: DUF389; cl00781 477641012983 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 477641012984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641012985 putative substrate translocation pore; other site 477641012986 Methyltransferase domain; Region: Methyltransf_31; pfam13847 477641012987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641012988 S-adenosylmethionine binding site [chemical binding]; other site 477641012989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 477641012990 trimer interface [polypeptide binding]; other site 477641012991 active site 477641012992 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 477641012993 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641012994 DNA binding residues [nucleotide binding] 477641012995 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 477641012996 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 477641012997 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 477641012998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641012999 dimerization interface [polypeptide binding]; other site 477641013000 putative DNA binding site [nucleotide binding]; other site 477641013001 putative Zn2+ binding site [ion binding]; other site 477641013002 TrwC relaxase; Region: TrwC; pfam08751 477641013003 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 477641013004 AAA domain; Region: AAA_30; pfam13604 477641013005 DNA binding domain, excisionase family; Region: excise; TIGR01764 477641013006 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641013007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 477641013008 active site 477641013009 Int/Topo IB signature motif; other site 477641013010 DNA binding site [nucleotide binding] 477641013011 Abi-like protein; Region: Abi_2; cl01988 477641013012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641013013 Coenzyme A binding pocket [chemical binding]; other site 477641013014 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 477641013015 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 477641013016 NAD binding site [chemical binding]; other site 477641013017 catalytic Zn binding site [ion binding]; other site 477641013018 structural Zn binding site [ion binding]; other site 477641013019 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 477641013020 amphipathic channel; other site 477641013021 Asn-Pro-Ala signature motifs; other site 477641013022 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 477641013023 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 477641013024 DAK2 domain; Region: Dak2; cl03685 477641013025 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 477641013026 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 477641013027 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 477641013028 active site 477641013029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641013030 S-adenosylmethionine binding site [chemical binding]; other site 477641013031 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 477641013032 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 477641013033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 477641013034 substrate binding site [chemical binding]; other site 477641013035 ATP binding site [chemical binding]; other site 477641013036 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 477641013037 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 477641013038 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 477641013039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 477641013040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641013041 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 477641013042 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 477641013043 ligand binding site [chemical binding]; other site 477641013044 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 477641013045 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 477641013046 TM-ABC transporter signature motif; other site 477641013047 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 477641013048 TM-ABC transporter signature motif; other site 477641013049 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 477641013050 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 477641013051 Walker A/P-loop; other site 477641013052 ATP binding site [chemical binding]; other site 477641013053 Q-loop/lid; other site 477641013054 ABC transporter signature motif; other site 477641013055 Walker B; other site 477641013056 D-loop; other site 477641013057 H-loop/switch region; other site 477641013058 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 477641013059 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 477641013060 Walker A/P-loop; other site 477641013061 ATP binding site [chemical binding]; other site 477641013062 Q-loop/lid; other site 477641013063 ABC transporter signature motif; other site 477641013064 Walker B; other site 477641013065 D-loop; other site 477641013066 H-loop/switch region; other site 477641013067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013069 NAD(P) binding site [chemical binding]; other site 477641013070 active site 477641013071 GAF domain; Region: GAF; pfam01590 477641013072 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 477641013073 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 477641013074 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 477641013075 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 477641013076 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 477641013077 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 477641013078 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 477641013079 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 477641013080 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 477641013081 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 477641013082 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 477641013083 putative substrate binding site [chemical binding]; other site 477641013084 putative ATP binding site [chemical binding]; other site 477641013085 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 477641013086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 477641013087 active site 477641013088 phosphorylation site [posttranslational modification] 477641013089 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 477641013090 active site 477641013091 P-loop; other site 477641013092 phosphorylation site [posttranslational modification] 477641013093 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 477641013094 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 477641013095 dimerization domain swap beta strand [polypeptide binding]; other site 477641013096 regulatory protein interface [polypeptide binding]; other site 477641013097 active site 477641013098 regulatory phosphorylation site [posttranslational modification]; other site 477641013099 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 477641013100 putative hydrophobic ligand binding site [chemical binding]; other site 477641013101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 477641013102 classical (c) SDRs; Region: SDR_c; cd05233 477641013103 NAD(P) binding site [chemical binding]; other site 477641013104 active site 477641013105 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 477641013106 putative active cleft [active] 477641013107 dimerization interface [polypeptide binding]; other site 477641013108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 477641013109 E3 interaction surface; other site 477641013110 lipoyl attachment site [posttranslational modification]; other site 477641013111 e3 binding domain; Region: E3_binding; pfam02817 477641013112 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 477641013113 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 477641013114 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 477641013115 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 477641013116 alpha subunit interface [polypeptide binding]; other site 477641013117 TPP binding site [chemical binding]; other site 477641013118 heterodimer interface [polypeptide binding]; other site 477641013119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 477641013120 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 477641013121 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 477641013122 TPP-binding site [chemical binding]; other site 477641013123 heterodimer interface [polypeptide binding]; other site 477641013124 tetramer interface [polypeptide binding]; other site 477641013125 phosphorylation loop region [posttranslational modification] 477641013126 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 477641013127 AsnC family; Region: AsnC_trans_reg; pfam01037 477641013128 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 477641013129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641013130 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641013131 active site 477641013132 catalytic tetrad [active] 477641013133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 477641013134 Beta-lactamase; Region: Beta-lactamase; pfam00144 477641013135 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 477641013136 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641013137 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641013138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 477641013139 Coenzyme A binding pocket [chemical binding]; other site 477641013140 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 477641013141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 477641013142 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 477641013143 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 477641013144 Part of AAA domain; Region: AAA_19; pfam13245 477641013145 PRC-barrel domain; Region: PRC; pfam05239 477641013146 Predicted esterase [General function prediction only]; Region: COG0400 477641013147 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 477641013148 B12 binding site [chemical binding]; other site 477641013149 cobalt ligand [ion binding]; other site 477641013150 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 477641013151 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 477641013152 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 477641013153 MarR family; Region: MarR; pfam01047 477641013154 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 477641013155 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 477641013156 intersubunit interface [polypeptide binding]; other site 477641013157 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 477641013158 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 477641013159 dimer interface [polypeptide binding]; other site 477641013160 active site 477641013161 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641013162 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 477641013163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 477641013164 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 477641013165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 477641013166 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 477641013167 active site 477641013168 substrate-binding site [chemical binding]; other site 477641013169 metal-binding site [ion binding] 477641013170 GTP binding site [chemical binding]; other site 477641013171 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 477641013172 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 477641013173 active site 477641013174 FMN binding site [chemical binding]; other site 477641013175 substrate binding site [chemical binding]; other site 477641013176 homotetramer interface [polypeptide binding]; other site 477641013177 catalytic residue [active] 477641013178 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 477641013179 putative hydrophobic ligand binding site [chemical binding]; other site 477641013180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641013181 dimerization interface [polypeptide binding]; other site 477641013182 putative DNA binding site [nucleotide binding]; other site 477641013183 putative Zn2+ binding site [ion binding]; other site 477641013184 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 477641013185 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 477641013186 FMN binding site [chemical binding]; other site 477641013187 substrate binding site [chemical binding]; other site 477641013188 putative catalytic residue [active] 477641013189 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 477641013190 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 477641013191 catalytic residues [active] 477641013192 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 477641013193 Cation efflux family; Region: Cation_efflux; pfam01545 477641013194 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641013195 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641013196 active site 477641013197 magnesium chelatase subunit H; Provisional; Region: PLN03241 477641013198 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 477641013199 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 477641013200 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 477641013201 DNA binding residues [nucleotide binding] 477641013202 putative dimer interface [polypeptide binding]; other site 477641013203 short chain dehydrogenase; Validated; Region: PRK08264 477641013204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013205 NAD(P) binding site [chemical binding]; other site 477641013206 active site 477641013207 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 477641013208 GAF domain; Region: GAF_3; pfam13492 477641013209 GAF domain; Region: GAF_2; pfam13185 477641013210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 477641013211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 477641013212 dimer interface [polypeptide binding]; other site 477641013213 phosphorylation site [posttranslational modification] 477641013214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641013215 ATP binding site [chemical binding]; other site 477641013216 Mg2+ binding site [ion binding]; other site 477641013217 G-X-G motif; other site 477641013218 Response regulator receiver domain; Region: Response_reg; pfam00072 477641013219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641013220 active site 477641013221 phosphorylation site [posttranslational modification] 477641013222 intermolecular recognition site; other site 477641013223 dimerization interface [polypeptide binding]; other site 477641013224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 477641013225 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 477641013226 Mg2+ binding site [ion binding]; other site 477641013227 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 477641013228 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 477641013229 NodB motif; other site 477641013230 active site 477641013231 catalytic site [active] 477641013232 metal binding site [ion binding]; metal-binding site 477641013233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 477641013234 Amidase; Region: Amidase; cl11426 477641013235 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 477641013236 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 477641013237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 477641013238 acyl-activating enzyme (AAE) consensus motif; other site 477641013239 AMP binding site [chemical binding]; other site 477641013240 active site 477641013241 CoA binding site [chemical binding]; other site 477641013242 CAAX protease self-immunity; Region: Abi; pfam02517 477641013243 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 477641013244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013245 NAD(P) binding site [chemical binding]; other site 477641013246 active site 477641013247 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 477641013248 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 477641013249 catalytic residues [active] 477641013250 dimer interface [polypeptide binding]; other site 477641013251 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 477641013252 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 477641013253 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641013254 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 477641013255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641013256 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 477641013257 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 477641013258 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 477641013259 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 477641013260 catalytic residues [active] 477641013261 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 477641013262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 477641013263 ligand binding site [chemical binding]; other site 477641013264 flexible hinge region; other site 477641013265 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 477641013266 carboxyltransferase (CT) interaction site; other site 477641013267 biotinylation site [posttranslational modification]; other site 477641013268 pyruvate carboxylase subunit A; Validated; Region: PRK08654 477641013269 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 477641013270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641013271 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 477641013272 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 477641013273 active site 477641013274 catalytic residues [active] 477641013275 metal binding site [ion binding]; metal-binding site 477641013276 homodimer binding site [polypeptide binding]; other site 477641013277 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 477641013278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013279 NAD(P) binding site [chemical binding]; other site 477641013280 active site 477641013281 HIRAN domain; Region: HIRAN; pfam08797 477641013282 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641013283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641013284 active site 477641013285 threonine dehydratase; Validated; Region: PRK08639 477641013286 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 477641013287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641013288 catalytic residue [active] 477641013289 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 477641013290 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 477641013291 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 477641013292 putative NAD(P) binding site [chemical binding]; other site 477641013293 catalytic Zn binding site [ion binding]; other site 477641013294 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 477641013295 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 477641013296 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 477641013297 active site 477641013298 P-loop; other site 477641013299 phosphorylation site [posttranslational modification] 477641013300 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 477641013301 active site 477641013302 phosphorylation site [posttranslational modification] 477641013303 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 477641013304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641013305 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641013306 active site 477641013307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641013308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 477641013309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 477641013310 ABC-ATPase subunit interface; other site 477641013311 dimer interface [polypeptide binding]; other site 477641013312 putative PBP binding regions; other site 477641013313 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 477641013314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 477641013315 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 477641013316 dimer interface [polypeptide binding]; other site 477641013317 putative PBP binding regions; other site 477641013318 ABC-ATPase subunit interface; other site 477641013319 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 477641013320 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 477641013321 Walker A/P-loop; other site 477641013322 ATP binding site [chemical binding]; other site 477641013323 Q-loop/lid; other site 477641013324 ABC transporter signature motif; other site 477641013325 Walker B; other site 477641013326 D-loop; other site 477641013327 H-loop/switch region; other site 477641013328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641013329 active site 477641013330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641013331 dimerization interface [polypeptide binding]; other site 477641013332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641013333 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641013334 dimer interface [polypeptide binding]; other site 477641013335 putative CheW interface [polypeptide binding]; other site 477641013336 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 477641013337 Mechanosensitive ion channel; Region: MS_channel; pfam00924 477641013338 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641013339 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 477641013340 putative NAD(P) binding site [chemical binding]; other site 477641013341 catalytic Zn binding site [ion binding]; other site 477641013342 structural Zn binding site [ion binding]; other site 477641013343 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641013344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641013345 catalytic residue [active] 477641013346 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 477641013347 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 477641013348 homodimer interface [polypeptide binding]; other site 477641013349 substrate-cofactor binding pocket; other site 477641013350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641013351 catalytic residue [active] 477641013352 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 477641013353 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 477641013354 Fatty acid desaturase; Region: FA_desaturase; pfam00487 477641013355 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 477641013356 putative di-iron ligands [ion binding]; other site 477641013357 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 477641013358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 477641013359 DNA binding residues [nucleotide binding] 477641013360 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 477641013361 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 477641013362 trimer interface [polypeptide binding]; other site 477641013363 putative metal binding site [ion binding]; other site 477641013364 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 477641013365 putative substrate binding site [chemical binding]; other site 477641013366 putative ATP binding site [chemical binding]; other site 477641013367 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 477641013368 catalytic core [active] 477641013369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 477641013370 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 477641013371 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 477641013372 NlpC/P60 family; Region: NLPC_P60; pfam00877 477641013373 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 477641013374 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 477641013375 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 477641013376 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 477641013377 active site 477641013378 catalytic triad [active] 477641013379 dimer interface [polypeptide binding]; other site 477641013380 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 477641013381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641013382 Predicted amidohydrolase [General function prediction only]; Region: COG0388 477641013383 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 477641013384 active site 477641013385 catalytic triad [active] 477641013386 dimer interface [polypeptide binding]; other site 477641013387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641013388 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 477641013389 dimerization interface [polypeptide binding]; other site 477641013390 ATP binding site [chemical binding]; other site 477641013391 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 477641013392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641013393 FeS/SAM binding site; other site 477641013394 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 477641013395 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 477641013396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 477641013397 active site 477641013398 serine hydroxymethyltransferase; Provisional; Region: PRK13580 477641013399 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 477641013400 dimer interface [polypeptide binding]; other site 477641013401 active site 477641013402 glycine-pyridoxal phosphate binding site [chemical binding]; other site 477641013403 folate binding site [chemical binding]; other site 477641013404 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 477641013405 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 477641013406 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 477641013407 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 477641013408 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 477641013409 short chain dehydrogenase; Provisional; Region: PRK06500 477641013410 classical (c) SDRs; Region: SDR_c; cd05233 477641013411 NAD(P) binding site [chemical binding]; other site 477641013412 active site 477641013413 SnoaL-like domain; Region: SnoaL_2; pfam12680 477641013414 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 477641013415 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 477641013416 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 477641013417 Transcriptional regulators [Transcription]; Region: MarR; COG1846 477641013418 MarR family; Region: MarR_2; pfam12802 477641013419 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 477641013420 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 477641013421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 477641013422 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 477641013423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 477641013424 active site 477641013425 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 477641013426 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 477641013427 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 477641013428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 477641013429 motif II; other site 477641013430 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 477641013431 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 477641013432 putative hydrophobic ligand binding site [chemical binding]; other site 477641013433 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 477641013434 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 477641013435 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 477641013436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 477641013437 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 477641013438 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 477641013439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 477641013440 catalytic loop [active] 477641013441 iron binding site [ion binding]; other site 477641013442 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 477641013443 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 477641013444 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 477641013445 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 477641013446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 477641013447 putative substrate translocation pore; other site 477641013448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 477641013449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 477641013450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 477641013451 putative dimerization interface [polypeptide binding]; other site 477641013452 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 477641013453 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 477641013454 RibD C-terminal domain; Region: RibD_C; cl17279 477641013455 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 477641013456 Isochorismatase family; Region: Isochorismatase; pfam00857 477641013457 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 477641013458 catalytic triad [active] 477641013459 conserved cis-peptide bond; other site 477641013460 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 477641013461 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 477641013462 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 477641013463 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 477641013464 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 477641013465 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 477641013466 siderophore binding site; other site 477641013467 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 477641013468 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 477641013469 siderophore binding site; other site 477641013470 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 477641013471 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 477641013472 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 477641013473 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 477641013474 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 477641013475 phosphate binding site [ion binding]; other site 477641013476 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 477641013477 metal ion-dependent adhesion site (MIDAS); other site 477641013478 MoxR-like ATPases [General function prediction only]; Region: COG0714 477641013479 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 477641013480 Walker A motif; other site 477641013481 ATP binding site [chemical binding]; other site 477641013482 Walker B motif; other site 477641013483 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 477641013484 classical (c) SDRs; Region: SDR_c; cd05233 477641013485 NAD(P) binding site [chemical binding]; other site 477641013486 active site 477641013487 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 477641013488 classical (c) SDRs; Region: SDR_c; cd05233 477641013489 NAD(P) binding site [chemical binding]; other site 477641013490 active site 477641013491 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 477641013492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641013493 FeS/SAM binding site; other site 477641013494 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 477641013495 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 477641013496 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 477641013497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641013498 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 477641013499 hydrophobic ligand binding site; other site 477641013500 ABC-2 type transporter; Region: ABC2_membrane; cl17235 477641013501 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 477641013502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641013503 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 477641013504 Walker A/P-loop; other site 477641013505 ATP binding site [chemical binding]; other site 477641013506 Q-loop/lid; other site 477641013507 ABC transporter signature motif; other site 477641013508 Walker B; other site 477641013509 D-loop; other site 477641013510 H-loop/switch region; other site 477641013511 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 477641013512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 477641013513 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 477641013514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641013515 active site 477641013516 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 477641013517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 477641013518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641013519 catalytic residue [active] 477641013520 FAD binding domain; Region: FAD_binding_3; pfam01494 477641013521 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641013522 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 477641013523 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 477641013524 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 477641013525 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 477641013526 NAD binding site [chemical binding]; other site 477641013527 catalytic Zn binding site [ion binding]; other site 477641013528 substrate binding site [chemical binding]; other site 477641013529 structural Zn binding site [ion binding]; other site 477641013530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641013531 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 477641013532 Walker A motif; other site 477641013533 ATP binding site [chemical binding]; other site 477641013534 Walker B motif; other site 477641013535 arginine finger; other site 477641013536 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 477641013537 metal ion-dependent adhesion site (MIDAS); other site 477641013538 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 477641013539 homotrimer interaction site [polypeptide binding]; other site 477641013540 putative active site [active] 477641013541 MOSC domain; Region: MOSC; pfam03473 477641013542 hypothetical protein; Provisional; Region: PRK07079 477641013543 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 477641013544 metal binding site [ion binding]; metal-binding site 477641013545 putative dimer interface [polypeptide binding]; other site 477641013546 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 477641013547 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 477641013548 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 477641013549 XdhC Rossmann domain; Region: XdhC_C; pfam13478 477641013550 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 477641013551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 477641013552 metal ion-dependent adhesion site (MIDAS); other site 477641013553 MoxR-like ATPases [General function prediction only]; Region: COG0714 477641013554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 477641013555 Walker A motif; other site 477641013556 ATP binding site [chemical binding]; other site 477641013557 Walker B motif; other site 477641013558 arginine finger; other site 477641013559 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 477641013560 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 477641013561 putative NAD(P) binding site [chemical binding]; other site 477641013562 putative substrate binding site [chemical binding]; other site 477641013563 catalytic Zn binding site [ion binding]; other site 477641013564 structural Zn binding site [ion binding]; other site 477641013565 dimer interface [polypeptide binding]; other site 477641013566 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 477641013567 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 477641013568 active site 477641013569 metal binding site [ion binding]; metal-binding site 477641013570 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 477641013571 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 477641013572 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 477641013573 metal binding site [ion binding]; metal-binding site 477641013574 active site 477641013575 I-site; other site 477641013576 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 477641013577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641013578 dimerization interface [polypeptide binding]; other site 477641013579 putative DNA binding site [nucleotide binding]; other site 477641013580 putative Zn2+ binding site [ion binding]; other site 477641013581 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 477641013582 putative hydrophobic ligand binding site [chemical binding]; other site 477641013583 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 477641013584 anti sigma factor interaction site; other site 477641013585 regulatory phosphorylation site [posttranslational modification]; other site 477641013586 Part of AAA domain; Region: AAA_19; pfam13245 477641013587 Family description; Region: UvrD_C_2; pfam13538 477641013588 hypothetical protein; Provisional; Region: PRK01842 477641013589 SEC-C motif; Region: SEC-C; pfam02810 477641013590 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 477641013591 threonine dehydratase; Provisional; Region: PRK08246 477641013592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 477641013593 catalytic residue [active] 477641013594 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 477641013595 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 477641013596 putative acyl-acceptor binding pocket; other site 477641013597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 477641013598 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 477641013599 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 477641013600 AMP-binding enzyme; Region: AMP-binding; pfam00501 477641013601 acyl-activating enzyme (AAE) consensus motif; other site 477641013602 AMP binding site [chemical binding]; other site 477641013603 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 477641013604 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 477641013605 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 477641013606 PRC-barrel domain; Region: PRC; pfam05239 477641013607 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 477641013608 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 477641013609 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641013610 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641013611 active site 477641013612 catalytic tetrad [active] 477641013613 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 477641013614 homotrimer interaction site [polypeptide binding]; other site 477641013615 putative active site [active] 477641013616 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 477641013617 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 477641013618 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 477641013619 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 477641013620 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 477641013621 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 477641013622 G1 box; other site 477641013623 putative GEF interaction site [polypeptide binding]; other site 477641013624 GTP/Mg2+ binding site [chemical binding]; other site 477641013625 Switch I region; other site 477641013626 G2 box; other site 477641013627 G3 box; other site 477641013628 Switch II region; other site 477641013629 G4 box; other site 477641013630 G5 box; other site 477641013631 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 477641013632 hypothetical protein; Provisional; Region: PRK01346 477641013633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 477641013634 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 477641013635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 477641013636 FeS/SAM binding site; other site 477641013637 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 477641013638 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 477641013639 MoaE interaction surface [polypeptide binding]; other site 477641013640 MoeB interaction surface [polypeptide binding]; other site 477641013641 thiocarboxylated glycine; other site 477641013642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641013643 PAS domain; Region: PAS_9; pfam13426 477641013644 putative active site [active] 477641013645 heme pocket [chemical binding]; other site 477641013646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641013647 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641013648 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641013649 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 477641013650 MoaD interaction [polypeptide binding]; other site 477641013651 active site residues [active] 477641013652 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 477641013653 metal-binding site 477641013654 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 477641013655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641013656 Walker A/P-loop; other site 477641013657 ATP binding site [chemical binding]; other site 477641013658 Q-loop/lid; other site 477641013659 ABC transporter signature motif; other site 477641013660 Walker B; other site 477641013661 D-loop; other site 477641013662 H-loop/switch region; other site 477641013663 TOBE domain; Region: TOBE; cl01440 477641013664 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 477641013665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 477641013666 putative PBP binding loops; other site 477641013667 ABC-ATPase subunit interface; other site 477641013668 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 477641013669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 477641013670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 477641013671 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 477641013672 DNA binding residues [nucleotide binding] 477641013673 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 477641013674 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 477641013675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641013676 ATP binding site [chemical binding]; other site 477641013677 putative Mg++ binding site [ion binding]; other site 477641013678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641013679 nucleotide binding region [chemical binding]; other site 477641013680 ATP-binding site [chemical binding]; other site 477641013681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 477641013682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 477641013683 Walker A/P-loop; other site 477641013684 ATP binding site [chemical binding]; other site 477641013685 Q-loop/lid; other site 477641013686 ABC transporter signature motif; other site 477641013687 Walker B; other site 477641013688 D-loop; other site 477641013689 H-loop/switch region; other site 477641013690 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 477641013691 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 477641013692 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 477641013693 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 477641013694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 477641013695 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 477641013696 active site 477641013697 potential frameshift: common BLAST hit: gi|330468723|ref|YP_004406466.1| regulatory protein LacI 477641013698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641013699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641013700 DNA binding site [nucleotide binding] 477641013701 domain linker motif; other site 477641013702 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641013703 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 477641013704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641013705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 477641013706 dimerization interface [polypeptide binding]; other site 477641013707 putative DNA binding site [nucleotide binding]; other site 477641013708 putative Zn2+ binding site [ion binding]; other site 477641013709 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641013710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 477641013711 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 477641013712 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 477641013713 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 477641013714 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 477641013715 N- and C-terminal domain interface [polypeptide binding]; other site 477641013716 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 477641013717 active site 477641013718 putative catalytic site [active] 477641013719 metal binding site [ion binding]; metal-binding site 477641013720 ATP binding site [chemical binding]; other site 477641013721 carbohydrate binding site [chemical binding]; other site 477641013722 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 477641013723 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 477641013724 ligand binding site [chemical binding]; other site 477641013725 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 477641013726 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 477641013727 Walker A/P-loop; other site 477641013728 ATP binding site [chemical binding]; other site 477641013729 Q-loop/lid; other site 477641013730 ABC transporter signature motif; other site 477641013731 Walker B; other site 477641013732 D-loop; other site 477641013733 H-loop/switch region; other site 477641013734 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 477641013735 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641013736 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641013737 TM-ABC transporter signature motif; other site 477641013738 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 477641013739 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 477641013740 TM-ABC transporter signature motif; other site 477641013741 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 477641013742 intersubunit interface [polypeptide binding]; other site 477641013743 active site 477641013744 Zn2+ binding site [ion binding]; other site 477641013745 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 477641013746 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 477641013747 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 477641013748 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641013749 nucleotide binding site [chemical binding]; other site 477641013750 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 477641013751 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 477641013752 Metal-binding active site; metal-binding site 477641013753 Homeodomain-like domain; Region: HTH_23; cl17451 477641013754 Winged helix-turn helix; Region: HTH_29; pfam13551 477641013755 Integrase core domain; Region: rve; pfam00665 477641013756 Integrase core domain; Region: rve_3; pfam13683 477641013757 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 477641013758 N- and C-terminal domain interface [polypeptide binding]; other site 477641013759 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 477641013760 active site 477641013761 putative catalytic site [active] 477641013762 metal binding site [ion binding]; metal-binding site 477641013763 ATP binding site [chemical binding]; other site 477641013764 carbohydrate binding site [chemical binding]; other site 477641013765 short chain dehydrogenase; Validated; Region: PRK08324 477641013766 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 477641013767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 477641013768 NAD(P) binding site [chemical binding]; other site 477641013769 active site 477641013770 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 477641013771 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 477641013772 Domain of unknown function (DUF718); Region: DUF718; pfam05336 477641013773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 477641013774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 477641013775 DNA binding site [nucleotide binding] 477641013776 domain linker motif; other site 477641013777 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 477641013778 dimerization interface [polypeptide binding]; other site 477641013779 ligand binding site [chemical binding]; other site 477641013780 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 477641013781 Cysteine-rich domain; Region: CCG; pfam02754 477641013782 Cysteine-rich domain; Region: CCG; pfam02754 477641013783 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 477641013784 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 477641013785 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 477641013786 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 477641013787 Transcriptional regulator [Transcription]; Region: LytR; COG1316 477641013788 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 477641013789 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 477641013790 homodimer interface [polypeptide binding]; other site 477641013791 putative substrate binding pocket [chemical binding]; other site 477641013792 diiron center [ion binding]; other site 477641013793 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 477641013794 putative catalytic site [active] 477641013795 putative phosphate binding site [ion binding]; other site 477641013796 active site 477641013797 metal binding site A [ion binding]; metal-binding site 477641013798 DNA binding site [nucleotide binding] 477641013799 putative AP binding site [nucleotide binding]; other site 477641013800 putative metal binding site B [ion binding]; other site 477641013801 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 477641013802 putative dimer interface [polypeptide binding]; other site 477641013803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641013804 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641013805 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641013806 active site 477641013807 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 477641013808 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 477641013809 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 477641013810 hypothetical protein; Validated; Region: PRK02101 477641013811 amidase; Provisional; Region: PRK07486 477641013812 Amidase; Region: Amidase; pfam01425 477641013813 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 477641013814 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 477641013815 Ca binding site [ion binding]; other site 477641013816 active site 477641013817 catalytic site [active] 477641013818 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 477641013819 Membrane protein of unknown function; Region: DUF360; pfam04020 477641013820 Uncharacterized conserved protein [Function unknown]; Region: COG0398 477641013821 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 477641013822 AAA ATPase domain; Region: AAA_16; pfam13191 477641013823 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 477641013824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 477641013825 PAS domain; Region: PAS; smart00091 477641013826 putative active site [active] 477641013827 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641013828 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 477641013829 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 477641013830 Response regulator receiver domain; Region: Response_reg; pfam00072 477641013831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641013832 active site 477641013833 phosphorylation site [posttranslational modification] 477641013834 intermolecular recognition site; other site 477641013835 dimerization interface [polypeptide binding]; other site 477641013836 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 477641013837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 477641013838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641013839 active site 477641013840 phosphorylation site [posttranslational modification] 477641013841 intermolecular recognition site; other site 477641013842 dimerization interface [polypeptide binding]; other site 477641013843 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 477641013844 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 477641013845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 477641013846 S-adenosylmethionine binding site [chemical binding]; other site 477641013847 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 477641013848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 477641013849 active site 477641013850 phosphorylation site [posttranslational modification] 477641013851 intermolecular recognition site; other site 477641013852 dimerization interface [polypeptide binding]; other site 477641013853 CheB methylesterase; Region: CheB_methylest; pfam01339 477641013854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641013855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641013856 dimer interface [polypeptide binding]; other site 477641013857 putative CheW interface [polypeptide binding]; other site 477641013858 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 477641013859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 477641013860 dimerization interface [polypeptide binding]; other site 477641013861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 477641013862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 477641013863 dimer interface [polypeptide binding]; other site 477641013864 putative CheW interface [polypeptide binding]; other site 477641013865 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 477641013866 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 477641013867 putative binding surface; other site 477641013868 active site 477641013869 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 477641013870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 477641013871 ATP binding site [chemical binding]; other site 477641013872 Mg2+ binding site [ion binding]; other site 477641013873 G-X-G motif; other site 477641013874 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 477641013875 CheW-like domain; Region: CheW; pfam01584 477641013876 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 477641013877 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 477641013878 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 477641013879 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 477641013880 active site 477641013881 homotetramer interface [polypeptide binding]; other site 477641013882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 477641013883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 477641013884 active site 477641013885 catalytic tetrad [active] 477641013886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 477641013887 PAS domain; Region: PAS_9; pfam13426 477641013888 putative active site [active] 477641013889 heme pocket [chemical binding]; other site 477641013890 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 477641013891 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 477641013892 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641013893 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 477641013894 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 477641013895 active site 477641013896 catalytic residues [active] 477641013897 metal binding site [ion binding]; metal-binding site 477641013898 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 477641013899 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 477641013900 metal binding site [ion binding]; metal-binding site 477641013901 dimer interface [polypeptide binding]; other site 477641013902 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 477641013903 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 477641013904 Transcriptional regulator [Transcription]; Region: IclR; COG1414 477641013905 glycerol kinase; Provisional; Region: glpK; PRK00047 477641013906 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 477641013907 nucleotide binding site [chemical binding]; other site 477641013908 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 477641013909 amphipathic channel; other site 477641013910 Asn-Pro-Ala signature motifs; other site 477641013911 glycerol kinase; Provisional; Region: glpK; PRK00047 477641013912 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 477641013913 N- and C-terminal domain interface [polypeptide binding]; other site 477641013914 active site 477641013915 MgATP binding site [chemical binding]; other site 477641013916 catalytic site [active] 477641013917 metal binding site [ion binding]; metal-binding site 477641013918 putative homotetramer interface [polypeptide binding]; other site 477641013919 glycerol binding site [chemical binding]; other site 477641013920 homodimer interface [polypeptide binding]; other site 477641013921 phosphoglucomutase; Validated; Region: PRK07564 477641013922 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 477641013923 active site 477641013924 substrate binding site [chemical binding]; other site 477641013925 metal binding site [ion binding]; metal-binding site 477641013926 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 477641013927 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 477641013928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641013929 ATP binding site [chemical binding]; other site 477641013930 putative Mg++ binding site [ion binding]; other site 477641013931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 477641013932 nucleotide binding region [chemical binding]; other site 477641013933 ATP-binding site [chemical binding]; other site 477641013934 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 477641013935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 477641013936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 477641013937 GAF domain; Region: GAF; pfam01590 477641013938 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 477641013939 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 477641013940 PGAP1-like protein; Region: PGAP1; pfam07819 477641013941 acyl-CoA esterase; Provisional; Region: PRK10673 477641013942 DEAD-like helicases superfamily; Region: DEXDc; smart00487 477641013943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 477641013944 ATP binding site [chemical binding]; other site 477641013945 putative Mg++ binding site [ion binding]; other site 477641013946 Helicase_C-like; Region: Helicase_C_4; pfam13871 477641013947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 477641013948 Domain of unknown function (DUF222); Region: DUF222; pfam02720 477641013949 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 477641013950 active site 477641013951 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 477641013952 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 477641013953 substrate binding site [chemical binding]; other site 477641013954 multimerization interface [polypeptide binding]; other site 477641013955 ATP binding site [chemical binding]; other site 477641013956 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 477641013957 thiamine phosphate binding site [chemical binding]; other site 477641013958 active site 477641013959 pyrophosphate binding site [ion binding]; other site 477641013960 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 477641013961 dimer interface [polypeptide binding]; other site 477641013962 substrate binding site [chemical binding]; other site 477641013963 ATP binding site [chemical binding]; other site 477641013964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 477641013965 binding surface 477641013966 TPR motif; other site 477641013967 DNA polymerase IV; Provisional; Region: PRK03348 477641013968 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 477641013969 active site 477641013970 DNA binding site [nucleotide binding] 477641013971 Methyltransferase domain; Region: Methyltransf_25; pfam13649 477641013972 S-adenosylmethionine binding site [chemical binding]; other site 477641013973 Bacterial Ig-like domain; Region: Big_5; pfam13205 477641013974 Cupin domain; Region: Cupin_2; pfam07883 477641013975 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 477641013976 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 477641013977 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 477641013978 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 477641013979 Walker A motif; other site 477641013980 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 477641013981 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 477641013982 replicative DNA helicase; Region: DnaB; TIGR00665 477641013983 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 477641013984 ATP binding site [chemical binding]; other site 477641013985 Walker B motif; other site 477641013986 DNA binding loops [nucleotide binding] 477641013987 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 477641013988 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 477641013989 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 477641013990 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 477641013991 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 477641013992 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 477641013993 dimer interface [polypeptide binding]; other site 477641013994 ssDNA binding site [nucleotide binding]; other site 477641013995 tetramer (dimer of dimers) interface [polypeptide binding]; other site 477641013996 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 477641013997 endonuclease IV; Provisional; Region: PRK01060 477641013998 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 477641013999 AP (apurinic/apyrimidinic) site pocket; other site 477641014000 DNA interaction; other site 477641014001 Metal-binding active site; metal-binding site 477641014002 Predicted integral membrane protein [Function unknown]; Region: COG5650 477641014003 Transglycosylase; Region: Transgly; pfam00912 477641014004 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 477641014005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 477641014006 Predicted transcriptional regulators [Transcription]; Region: COG1695 477641014007 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 477641014008 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 477641014009 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 477641014010 hypothetical protein; Validated; Region: PRK00228 477641014011 H+ Antiporter protein; Region: 2A0121; TIGR00900 477641014012 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 477641014013 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 477641014014 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 477641014015 active site 477641014016 NTP binding site [chemical binding]; other site 477641014017 metal binding triad [ion binding]; metal-binding site 477641014018 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 477641014019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 477641014020 Zn2+ binding site [ion binding]; other site 477641014021 Mg2+ binding site [ion binding]; other site 477641014022 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 477641014023 active site 477641014024 Ap6A binding site [chemical binding]; other site 477641014025 nudix motif; other site 477641014026 metal binding site [ion binding]; metal-binding site 477641014027 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 477641014028 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 477641014029 Protein kinase domain; Region: Pkinase; pfam00069 477641014030 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 477641014031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 477641014032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 477641014033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 477641014034 catalytic residues [active] 477641014035 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 477641014036 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 477641014037 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 477641014038 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 477641014039 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 477641014040 active site 477641014041 metal binding site [ion binding]; metal-binding site 477641014042 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 477641014043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 477641014044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 477641014045 homodimer interface [polypeptide binding]; other site 477641014046 catalytic residue [active] 477641014047 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 477641014048 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 477641014049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 477641014050 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 477641014051 ParB-like nuclease domain; Region: ParBc; pfam02195 477641014052 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 477641014053 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641014054 P-loop; other site 477641014055 Magnesium ion binding site [ion binding]; other site 477641014056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 477641014057 Magnesium ion binding site [ion binding]; other site 477641014058 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 477641014059 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 477641014060 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 477641014061 G-X-X-G motif; other site 477641014062 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 477641014063 RxxxH motif; other site 477641014064 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 477641014065 Haemolytic domain; Region: Haemolytic; pfam01809 477641014066 Ribonuclease P; Region: Ribonuclease_P; cl00457 477641014067 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399