-- dump date 20140619_150325 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264732000001 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 264732000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 264732000003 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264732000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000005 Walker A motif; other site 264732000006 ATP binding site [chemical binding]; other site 264732000007 Walker B motif; other site 264732000008 arginine finger; other site 264732000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264732000010 DnaA box-binding interface [nucleotide binding]; other site 264732000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 264732000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264732000013 putative DNA binding surface [nucleotide binding]; other site 264732000014 dimer interface [polypeptide binding]; other site 264732000015 beta-clamp/clamp loader binding surface; other site 264732000016 beta-clamp/translesion DNA polymerase binding surface; other site 264732000017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732000018 RNA binding surface [nucleotide binding]; other site 264732000019 recombination protein F; Reviewed; Region: recF; PRK00064 264732000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732000021 Walker A/P-loop; other site 264732000022 ATP binding site [chemical binding]; other site 264732000023 Q-loop/lid; other site 264732000024 ABC transporter signature motif; other site 264732000025 Walker B; other site 264732000026 D-loop; other site 264732000027 H-loop/switch region; other site 264732000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 264732000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732000030 ATP binding site [chemical binding]; other site 264732000031 Mg2+ binding site [ion binding]; other site 264732000032 G-X-G motif; other site 264732000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264732000034 anchoring element; other site 264732000035 dimer interface [polypeptide binding]; other site 264732000036 ATP binding site [chemical binding]; other site 264732000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264732000038 active site 264732000039 putative metal-binding site [ion binding]; other site 264732000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264732000041 DNA gyrase subunit A; Validated; Region: PRK05560 264732000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264732000043 CAP-like domain; other site 264732000044 active site 264732000045 primary dimer interface [polypeptide binding]; other site 264732000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264732000052 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 264732000053 active site 264732000054 multimer interface [polypeptide binding]; other site 264732000055 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 264732000056 predicted active site [active] 264732000057 catalytic triad [active] 264732000058 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264732000059 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264732000060 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264732000061 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 264732000062 putative substrate binding site [chemical binding]; other site 264732000063 putative ATP binding site [chemical binding]; other site 264732000064 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 264732000065 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 264732000066 active site 264732000067 P-loop; other site 264732000068 phosphorylation site [posttranslational modification] 264732000069 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 264732000070 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264732000071 active site 264732000072 phosphorylation site [posttranslational modification] 264732000073 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264732000074 dimerization domain swap beta strand [polypeptide binding]; other site 264732000075 regulatory protein interface [polypeptide binding]; other site 264732000076 active site 264732000077 regulatory phosphorylation site [posttranslational modification]; other site 264732000078 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264732000079 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 264732000080 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264732000081 Dehydratase family; Region: ILVD_EDD; cl00340 264732000082 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264732000083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732000084 catalytic residue [active] 264732000085 homodimer interface [polypeptide binding]; other site 264732000086 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264732000087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732000088 S-adenosylmethionine binding site [chemical binding]; other site 264732000089 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 264732000090 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 264732000091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732000092 catalytic residue [active] 264732000093 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 264732000094 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 264732000095 ligand binding site [chemical binding]; other site 264732000096 NAD binding site [chemical binding]; other site 264732000097 dimerization interface [polypeptide binding]; other site 264732000098 catalytic site [active] 264732000099 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 264732000100 putative L-serine binding site [chemical binding]; other site 264732000101 seryl-tRNA synthetase; Provisional; Region: PRK05431 264732000102 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264732000103 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264732000104 dimer interface [polypeptide binding]; other site 264732000105 active site 264732000106 motif 1; other site 264732000107 motif 2; other site 264732000108 motif 3; other site 264732000109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264732000110 Histidine kinase; Region: HisKA_3; pfam07730 264732000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732000112 ATP binding site [chemical binding]; other site 264732000113 Mg2+ binding site [ion binding]; other site 264732000114 G-X-G motif; other site 264732000115 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264732000116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732000117 active site 264732000118 phosphorylation site [posttranslational modification] 264732000119 intermolecular recognition site; other site 264732000120 dimerization interface [polypeptide binding]; other site 264732000121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264732000122 DNA binding residues [nucleotide binding] 264732000123 dimerization interface [polypeptide binding]; other site 264732000124 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264732000125 nucleoside/Zn binding site; other site 264732000126 dimer interface [polypeptide binding]; other site 264732000127 catalytic motif [active] 264732000128 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 264732000129 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 264732000130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000131 Walker A motif; other site 264732000132 ATP binding site [chemical binding]; other site 264732000133 Walker B motif; other site 264732000134 arginine finger; other site 264732000135 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264732000136 hypothetical protein; Validated; Region: PRK00153 264732000137 recombination protein RecR; Reviewed; Region: recR; PRK00076 264732000138 RecR protein; Region: RecR; pfam02132 264732000139 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264732000140 putative active site [active] 264732000141 putative metal-binding site [ion binding]; other site 264732000142 tetramer interface [polypeptide binding]; other site 264732000143 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 264732000144 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 264732000145 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 264732000146 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732000147 dimer interface [polypeptide binding]; other site 264732000148 PYR/PP interface [polypeptide binding]; other site 264732000149 TPP binding site [chemical binding]; other site 264732000150 substrate binding site [chemical binding]; other site 264732000151 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264732000152 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 264732000153 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264732000154 TPP-binding site [chemical binding]; other site 264732000155 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 264732000156 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732000157 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732000158 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264732000159 FAD binding domain; Region: FAD_binding_4; pfam01565 264732000160 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 264732000161 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732000162 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732000163 Cysteine-rich domain; Region: CCG; pfam02754 264732000164 Cysteine-rich domain; Region: CCG; pfam02754 264732000165 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264732000166 NodB motif; other site 264732000167 active site 264732000168 catalytic site [active] 264732000169 metal binding site [ion binding]; metal-binding site 264732000170 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 264732000171 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 264732000172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732000173 catalytic residue [active] 264732000174 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 264732000175 thymidylate kinase; Validated; Region: tmk; PRK00698 264732000176 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264732000177 TMP-binding site; other site 264732000178 ATP-binding site [chemical binding]; other site 264732000179 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 264732000180 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264732000181 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 264732000182 Protein of unknown function (DUF972); Region: DUF972; pfam06156 264732000183 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264732000184 putative SAM binding site [chemical binding]; other site 264732000185 putative homodimer interface [polypeptide binding]; other site 264732000186 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 264732000187 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 264732000188 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264732000189 active site 264732000190 HIGH motif; other site 264732000191 KMSKS motif; other site 264732000192 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264732000193 tRNA binding surface [nucleotide binding]; other site 264732000194 anticodon binding site; other site 264732000195 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264732000196 dimer interface [polypeptide binding]; other site 264732000197 putative tRNA-binding site [nucleotide binding]; other site 264732000198 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264732000199 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 264732000200 active site 264732000201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 264732000202 G5 domain; Region: G5; pfam07501 264732000203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 264732000204 Domain of unknown function (DUF348); Region: DUF348; pfam03990 264732000205 Domain of unknown function (DUF348); Region: DUF348; pfam03990 264732000206 G5 domain; Region: G5; pfam07501 264732000207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 264732000208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732000209 S-adenosylmethionine binding site [chemical binding]; other site 264732000210 Protein of unknown function (DUF458); Region: DUF458; pfam04308 264732000211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732000212 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264732000213 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732000214 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 264732000215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264732000216 active site 264732000217 YabG peptidase U57; Region: Peptidase_U57; cl05250 264732000218 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 264732000219 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264732000220 Ligand binding site [chemical binding]; other site 264732000221 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264732000222 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264732000223 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264732000224 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264732000225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732000226 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732000227 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732000228 Ferritin-like domain; Region: Ferritin; pfam00210 264732000229 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264732000230 dinuclear metal binding motif [ion binding]; other site 264732000231 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 264732000232 active site 264732000233 Glyco_18 domain; Region: Glyco_18; smart00636 264732000234 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 264732000235 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732000236 dimer interface [polypeptide binding]; other site 264732000237 PYR/PP interface [polypeptide binding]; other site 264732000238 TPP binding site [chemical binding]; other site 264732000239 substrate binding site [chemical binding]; other site 264732000240 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264732000241 Domain of unknown function; Region: EKR; pfam10371 264732000242 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 264732000243 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 264732000244 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 264732000245 TPP-binding site [chemical binding]; other site 264732000246 dimer interface [polypeptide binding]; other site 264732000247 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 264732000248 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 264732000249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732000250 dimer interface [polypeptide binding]; other site 264732000251 conserved gate region; other site 264732000252 putative PBP binding loops; other site 264732000253 ABC-ATPase subunit interface; other site 264732000254 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264732000255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732000256 Walker A/P-loop; other site 264732000257 ATP binding site [chemical binding]; other site 264732000258 Q-loop/lid; other site 264732000259 ABC transporter signature motif; other site 264732000260 Walker B; other site 264732000261 D-loop; other site 264732000262 H-loop/switch region; other site 264732000263 TOBE domain; Region: TOBE_2; pfam08402 264732000264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732000265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732000266 active site 264732000267 phosphorylation site [posttranslational modification] 264732000268 intermolecular recognition site; other site 264732000269 dimerization interface [polypeptide binding]; other site 264732000270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264732000271 DNA binding site [nucleotide binding] 264732000272 Late competence development protein ComFB; Region: ComFB; pfam10719 264732000273 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 264732000274 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264732000275 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264732000276 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264732000277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732000278 DNA-binding site [nucleotide binding]; DNA binding site 264732000279 FCD domain; Region: FCD; pfam07729 264732000280 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 264732000281 active site 264732000282 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 264732000283 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264732000284 Substrate binding site; other site 264732000285 Mg++ binding site; other site 264732000286 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264732000287 active site 264732000288 substrate binding site [chemical binding]; other site 264732000289 CoA binding site [chemical binding]; other site 264732000290 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264732000291 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264732000292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732000293 active site 264732000294 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 264732000295 PRC-barrel domain; Region: PRC; pfam05239 264732000296 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 264732000297 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264732000298 5S rRNA interface [nucleotide binding]; other site 264732000299 CTC domain interface [polypeptide binding]; other site 264732000300 L16 interface [polypeptide binding]; other site 264732000301 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 264732000302 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264732000303 putative active site [active] 264732000304 catalytic residue [active] 264732000305 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264732000306 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 264732000307 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 264732000308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732000309 ATP binding site [chemical binding]; other site 264732000310 putative Mg++ binding site [ion binding]; other site 264732000311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732000312 nucleotide binding region [chemical binding]; other site 264732000313 ATP-binding site [chemical binding]; other site 264732000314 TRCF domain; Region: TRCF; pfam03461 264732000315 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264732000316 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264732000317 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 264732000318 stage V sporulation protein T; Region: spore_V_T; TIGR02851 264732000319 GAF domain; Region: GAF_2; pfam13185 264732000320 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 264732000321 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 264732000322 putative SAM binding site [chemical binding]; other site 264732000323 putative homodimer interface [polypeptide binding]; other site 264732000324 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 264732000325 homodimer interface [polypeptide binding]; other site 264732000326 metal binding site [ion binding]; metal-binding site 264732000327 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 264732000328 homodimer interface [polypeptide binding]; other site 264732000329 active site 264732000330 putative chemical substrate binding site [chemical binding]; other site 264732000331 metal binding site [ion binding]; metal-binding site 264732000332 histone-like DNA-binding protein HU; Region: HU; cd13831 264732000333 dimer interface [polypeptide binding]; other site 264732000334 DNA binding site [nucleotide binding] 264732000335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732000336 RNA binding surface [nucleotide binding]; other site 264732000337 Stage II sporulation protein; Region: SpoIID; pfam08486 264732000338 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 264732000339 YabP family; Region: YabP; cl06766 264732000340 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 264732000341 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264732000342 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264732000343 DNA binding residues [nucleotide binding] 264732000344 Septum formation initiator; Region: DivIC; pfam04977 264732000345 hypothetical protein; Provisional; Region: PRK08582 264732000346 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 264732000347 RNA binding site [nucleotide binding]; other site 264732000348 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 264732000349 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 264732000350 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 264732000351 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 264732000352 putative active site [active] 264732000353 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264732000354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264732000355 substrate binding pocket [chemical binding]; other site 264732000356 membrane-bound complex binding site; other site 264732000357 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264732000358 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264732000359 Walker A/P-loop; other site 264732000360 ATP binding site [chemical binding]; other site 264732000361 Q-loop/lid; other site 264732000362 ABC transporter signature motif; other site 264732000363 Walker B; other site 264732000364 D-loop; other site 264732000365 H-loop/switch region; other site 264732000366 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264732000367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732000368 dimer interface [polypeptide binding]; other site 264732000369 conserved gate region; other site 264732000370 putative PBP binding loops; other site 264732000371 ABC-ATPase subunit interface; other site 264732000372 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264732000373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 264732000374 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264732000375 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264732000376 Protein of unknown function, DUF606; Region: DUF606; pfam04657 264732000377 stage II sporulation protein E; Region: spore_II_E; TIGR02865 264732000378 active site 264732000379 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264732000380 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 264732000381 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264732000382 Ligand Binding Site [chemical binding]; other site 264732000383 TilS substrate C-terminal domain; Region: TilS_C; smart00977 264732000384 FtsH Extracellular; Region: FtsH_ext; pfam06480 264732000385 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264732000386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000387 Walker A motif; other site 264732000388 ATP binding site [chemical binding]; other site 264732000389 Walker B motif; other site 264732000390 arginine finger; other site 264732000391 Peptidase family M41; Region: Peptidase_M41; pfam01434 264732000392 Nucleoside diphosphate kinase; Region: NDK; pfam00334 264732000393 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264732000394 active site 264732000395 multimer interface [polypeptide binding]; other site 264732000396 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 264732000397 HTH domain; Region: HTH_11; cl17392 264732000398 3H domain; Region: 3H; pfam02829 264732000399 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 264732000400 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 264732000401 Potassium binding sites [ion binding]; other site 264732000402 Cesium cation binding sites [ion binding]; other site 264732000403 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 264732000404 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264732000405 substrate binding pocket [chemical binding]; other site 264732000406 dimer interface [polypeptide binding]; other site 264732000407 inhibitor binding site; inhibition site 264732000408 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264732000409 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264732000410 active site 264732000411 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 264732000412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732000413 dimer interface [polypeptide binding]; other site 264732000414 conserved gate region; other site 264732000415 putative PBP binding loops; other site 264732000416 ABC-ATPase subunit interface; other site 264732000417 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 264732000418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732000419 dimer interface [polypeptide binding]; other site 264732000420 conserved gate region; other site 264732000421 putative PBP binding loops; other site 264732000422 ABC-ATPase subunit interface; other site 264732000423 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 264732000424 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264732000425 Walker A/P-loop; other site 264732000426 ATP binding site [chemical binding]; other site 264732000427 Q-loop/lid; other site 264732000428 ABC transporter signature motif; other site 264732000429 Walker B; other site 264732000430 D-loop; other site 264732000431 H-loop/switch region; other site 264732000432 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 264732000433 PhoU domain; Region: PhoU; pfam01895 264732000434 PhoU domain; Region: PhoU; pfam01895 264732000435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732000436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264732000437 putative substrate translocation pore; other site 264732000438 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 264732000439 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 264732000440 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 264732000441 Protein of unknown function (DUF441); Region: DUF441; pfam04284 264732000442 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264732000443 oligomerization interface [polypeptide binding]; other site 264732000444 active site 264732000445 metal binding site [ion binding]; metal-binding site 264732000446 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 264732000447 oligomer interface [polypeptide binding]; other site 264732000448 putative active site [active] 264732000449 metal binding site [ion binding]; metal-binding site 264732000450 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 264732000451 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 264732000452 CPxP motif; other site 264732000453 DsrE/DsrF-like family; Region: DrsE; pfam02635 264732000454 HEAT repeats; Region: HEAT_2; pfam13646 264732000455 HEAT repeats; Region: HEAT_2; pfam13646 264732000456 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 264732000457 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 264732000458 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 264732000459 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264732000460 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264732000461 dimer interface [polypeptide binding]; other site 264732000462 ssDNA binding site [nucleotide binding]; other site 264732000463 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264732000464 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264732000465 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 264732000466 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264732000467 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264732000468 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264732000469 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 264732000470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000471 Walker A motif; other site 264732000472 ATP binding site [chemical binding]; other site 264732000473 Walker B motif; other site 264732000474 arginine finger; other site 264732000475 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264732000476 replicative DNA helicase; Region: DnaB; TIGR00665 264732000477 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264732000478 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264732000479 Walker A motif; other site 264732000480 ATP binding site [chemical binding]; other site 264732000481 Walker B motif; other site 264732000482 DNA binding loops [nucleotide binding] 264732000483 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 264732000484 putative ADP-ribose binding site [chemical binding]; other site 264732000485 putative active site [active] 264732000486 Protein of unknown function (DUF763); Region: DUF763; pfam05559 264732000487 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 264732000488 cubane metal cluster [ion binding]; other site 264732000489 hybrid metal cluster; other site 264732000490 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264732000491 catalytic center binding site [active] 264732000492 ATP binding site [chemical binding]; other site 264732000493 Uncharacterized conserved protein [Function unknown]; Region: COG5495 264732000494 Rossmann-like domain; Region: Rossmann-like; pfam10727 264732000495 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 264732000496 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264732000497 active site 264732000498 ATP-binding site [chemical binding]; other site 264732000499 pantoate-binding site; other site 264732000500 HXXH motif; other site 264732000501 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 264732000502 tetramerization interface [polypeptide binding]; other site 264732000503 active site 264732000504 Biotin operon repressor [Transcription]; Region: BirA; COG1654 264732000505 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 264732000506 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 264732000507 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 264732000508 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 264732000509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264732000510 nucleotide binding site [chemical binding]; other site 264732000511 Type III pantothenate kinase; Region: Pan_kinase; cl17198 264732000512 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264732000513 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264732000514 FMN binding site [chemical binding]; other site 264732000515 active site 264732000516 catalytic residues [active] 264732000517 substrate binding site [chemical binding]; other site 264732000518 Helix-turn-helix domain; Region: HTH_38; pfam13936 264732000519 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 264732000520 NAD(P) binding pocket [chemical binding]; other site 264732000521 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264732000522 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264732000523 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264732000524 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264732000525 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264732000526 dimer interface [polypeptide binding]; other site 264732000527 putative anticodon binding site; other site 264732000528 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264732000529 motif 1; other site 264732000530 active site 264732000531 motif 2; other site 264732000532 motif 3; other site 264732000533 TIGR04076 family protein; Region: TIGR04076 264732000534 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 264732000535 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732000536 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 264732000537 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 264732000538 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 264732000539 Ubiquitin-like proteins; Region: UBQ; cl00155 264732000540 charged pocket; other site 264732000541 hydrophobic patch; other site 264732000542 amino acid transporter; Region: 2A0306; TIGR00909 264732000543 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 264732000544 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264732000545 substrate binding pocket [chemical binding]; other site 264732000546 chain length determination region; other site 264732000547 substrate-Mg2+ binding site; other site 264732000548 catalytic residues [active] 264732000549 aspartate-rich region 1; other site 264732000550 active site lid residues [active] 264732000551 aspartate-rich region 2; other site 264732000552 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 264732000553 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 264732000554 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 264732000555 UvrB/uvrC motif; Region: UVR; pfam02151 264732000556 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 264732000557 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 264732000558 ADP binding site [chemical binding]; other site 264732000559 phosphagen binding site; other site 264732000560 substrate specificity loop; other site 264732000561 Clp protease ATP binding subunit; Region: clpC; CHL00095 264732000562 Clp amino terminal domain; Region: Clp_N; pfam02861 264732000563 Clp amino terminal domain; Region: Clp_N; pfam02861 264732000564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000565 Walker A motif; other site 264732000566 ATP binding site [chemical binding]; other site 264732000567 Walker B motif; other site 264732000568 arginine finger; other site 264732000569 UvrB/uvrC motif; Region: UVR; pfam02151 264732000570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000571 Walker A motif; other site 264732000572 ATP binding site [chemical binding]; other site 264732000573 Walker B motif; other site 264732000574 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264732000575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264732000576 active site 264732000577 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 264732000578 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 264732000579 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732000580 Uncharacterized conserved protein [Function unknown]; Region: COG2442 264732000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 264732000582 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 264732000583 SIR2-like domain; Region: SIR2_2; pfam13289 264732000584 AAA domain; Region: AAA_23; pfam13476 264732000585 Walker A/P-loop; other site 264732000586 ATP binding site [chemical binding]; other site 264732000587 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732000588 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732000589 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 264732000590 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264732000591 putative active site [active] 264732000592 Helix-turn-helix domain; Region: HTH_17; cl17695 264732000593 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732000594 active site 264732000595 NTP binding site [chemical binding]; other site 264732000596 metal binding triad [ion binding]; metal-binding site 264732000597 antibiotic binding site [chemical binding]; other site 264732000598 Protein of unknown function DUF86; Region: DUF86; pfam01934 264732000599 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732000600 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732000601 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 264732000602 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 264732000603 Helix-turn-helix domain; Region: HTH_17; pfam12728 264732000604 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 264732000605 putative active site [active] 264732000606 homotetrameric interface [polypeptide binding]; other site 264732000607 metal binding site [ion binding]; metal-binding site 264732000608 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732000609 active site 264732000610 NTP binding site [chemical binding]; other site 264732000611 metal binding triad [ion binding]; metal-binding site 264732000612 antibiotic binding site [chemical binding]; other site 264732000613 Uncharacterized conserved protein [Function unknown]; Region: COG2445 264732000614 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 264732000615 S-layer homology domain; Region: SLH; pfam00395 264732000616 S-layer homology domain; Region: SLH; pfam00395 264732000617 S-layer homology domain; Region: SLH; pfam00395 264732000618 S-layer homology domain; Region: SLH; pfam00395 264732000619 S-layer homology domain; Region: SLH; pfam00395 264732000620 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 264732000621 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 264732000622 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264732000623 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264732000624 BON domain; Region: BON; pfam04972 264732000625 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 264732000626 putative active site [active] 264732000627 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264732000628 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 264732000629 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264732000630 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732000631 FeS/SAM binding site; other site 264732000632 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 264732000633 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 264732000634 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 264732000635 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 264732000636 Ligand Binding Site [chemical binding]; other site 264732000637 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 264732000638 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732000639 catalytic residue [active] 264732000640 germination protein YpeB; Region: spore_YpeB; TIGR02889 264732000641 YpeB sporulation; Region: YPEB; pfam14620 264732000642 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 264732000643 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 264732000644 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 264732000645 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 264732000646 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264732000647 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264732000648 OPT oligopeptide transporter protein; Region: OPT; cl14607 264732000649 Protein of unknown function (DUF917); Region: DUF917; cl17829 264732000650 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 264732000651 AroM protein; Region: AroM; pfam07302 264732000652 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 264732000653 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 264732000654 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264732000655 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264732000656 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264732000657 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 264732000658 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264732000659 Mg++ binding site [ion binding]; other site 264732000660 putative catalytic motif [active] 264732000661 substrate binding site [chemical binding]; other site 264732000662 Trimeric coiled-coil oligomerization domain of matrilin; Region: Matrilin_ccoil; pfam10393 264732000663 Predicted membrane protein [Function unknown]; Region: COG2323 264732000664 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 264732000665 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 264732000666 active site 264732000667 substrate binding site [chemical binding]; other site 264732000668 metal binding site [ion binding]; metal-binding site 264732000669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732000670 metal binding site [ion binding]; metal-binding site 264732000671 active site 264732000672 I-site; other site 264732000673 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 264732000674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732000675 ATP binding site [chemical binding]; other site 264732000676 putative Mg++ binding site [ion binding]; other site 264732000677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732000678 nucleotide binding region [chemical binding]; other site 264732000679 ATP-binding site [chemical binding]; other site 264732000680 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264732000681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 264732000682 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264732000683 DNA-binding site [nucleotide binding]; DNA binding site 264732000684 RNA-binding motif; other site 264732000685 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264732000686 30S subunit binding site; other site 264732000687 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 264732000688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732000689 ATP binding site [chemical binding]; other site 264732000690 putative Mg++ binding site [ion binding]; other site 264732000691 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 264732000692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732000693 nucleotide binding region [chemical binding]; other site 264732000694 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 264732000695 SEC-C motif; Region: SEC-C; cl19389 264732000696 peptide chain release factor 2; Provisional; Region: PRK05589 264732000697 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264732000698 RF-1 domain; Region: RF-1; pfam00472 264732000699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732000700 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264732000701 FeS/SAM binding site; other site 264732000702 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 264732000703 LexA repressor; Validated; Region: PRK00215 264732000704 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 264732000705 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264732000706 active site 264732000707 ATP binding site [chemical binding]; other site 264732000708 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732000709 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732000710 Uncharacterized conserved protein [Function unknown]; Region: COG1284 264732000711 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 264732000712 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 264732000713 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 264732000714 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264732000715 TPP-binding site [chemical binding]; other site 264732000716 dimer interface [polypeptide binding]; other site 264732000717 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 264732000718 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264732000719 PYR/PP interface [polypeptide binding]; other site 264732000720 dimer interface [polypeptide binding]; other site 264732000721 TPP binding site [chemical binding]; other site 264732000722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264732000723 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732000724 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732000725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732000726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000727 non-specific DNA binding site [nucleotide binding]; other site 264732000728 salt bridge; other site 264732000729 sequence-specific DNA binding site [nucleotide binding]; other site 264732000730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732000732 non-specific DNA binding site [nucleotide binding]; other site 264732000733 salt bridge; other site 264732000734 sequence-specific DNA binding site [nucleotide binding]; other site 264732000735 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 264732000736 Bacterial Ig-like domain; Region: Big_5; pfam13205 264732000737 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 264732000738 IPT/TIG domain; Region: TIG; pfam01833 264732000739 Bacterial Ig-like domain; Region: Big_5; pfam13205 264732000740 Latrophilin/CL-1-like GPS domain; Region: GPS; cl02559 264732000741 S-layer homology domain; Region: SLH; pfam00395 264732000742 S-layer homology domain; Region: SLH; pfam00395 264732000743 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 264732000744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732000745 Walker A/P-loop; other site 264732000746 ATP binding site [chemical binding]; other site 264732000747 Q-loop/lid; other site 264732000748 ABC transporter signature motif; other site 264732000749 Walker B; other site 264732000750 D-loop; other site 264732000751 H-loop/switch region; other site 264732000752 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 264732000753 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 264732000754 FtsX-like permease family; Region: FtsX; pfam02687 264732000755 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 264732000756 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732000757 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732000758 C-terminal peptidase (prc); Region: prc; TIGR00225 264732000759 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264732000760 protein binding site [polypeptide binding]; other site 264732000761 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264732000762 Catalytic dyad [active] 264732000763 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264732000764 catalytic triad [active] 264732000765 conserved cis-peptide bond; other site 264732000766 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 264732000767 YcfA-like protein; Region: YcfA; cl00752 264732000768 excinuclease ABC subunit B; Provisional; Region: PRK05298 264732000769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732000770 ATP binding site [chemical binding]; other site 264732000771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732000772 nucleotide binding region [chemical binding]; other site 264732000773 ATP-binding site [chemical binding]; other site 264732000774 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264732000775 UvrB/uvrC motif; Region: UVR; pfam02151 264732000776 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264732000777 putative active site [active] 264732000778 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264732000779 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 264732000780 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264732000781 Part of AAA domain; Region: AAA_19; pfam13245 264732000782 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264732000783 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 264732000784 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264732000785 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264732000786 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264732000787 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264732000788 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264732000789 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264732000790 GIY-YIG motif/motif A; other site 264732000791 active site 264732000792 catalytic site [active] 264732000793 putative DNA binding site [nucleotide binding]; other site 264732000794 metal binding site [ion binding]; metal-binding site 264732000795 UvrB/uvrC motif; Region: UVR; pfam02151 264732000796 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264732000797 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 264732000798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732000799 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264732000800 active site 264732000801 motif I; other site 264732000802 motif II; other site 264732000803 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 264732000804 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 264732000805 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 264732000806 phosphate binding site [ion binding]; other site 264732000807 putative substrate binding pocket [chemical binding]; other site 264732000808 dimer interface [polypeptide binding]; other site 264732000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 264732000810 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 264732000811 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 264732000812 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 264732000813 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264732000814 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264732000815 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264732000816 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264732000817 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 264732000818 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264732000819 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264732000820 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 264732000821 substrate binding site [chemical binding]; other site 264732000822 hinge regions; other site 264732000823 ADP binding site [chemical binding]; other site 264732000824 catalytic site [active] 264732000825 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264732000826 substrate binding site [chemical binding]; other site 264732000827 dimer interface [polypeptide binding]; other site 264732000828 catalytic triad [active] 264732000829 phosphoglyceromutase; Provisional; Region: PRK05434 264732000830 enolase; Provisional; Region: eno; PRK00077 264732000831 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264732000832 dimer interface [polypeptide binding]; other site 264732000833 metal binding site [ion binding]; metal-binding site 264732000834 substrate binding pocket [chemical binding]; other site 264732000835 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264732000836 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 264732000837 oligomer interface [polypeptide binding]; other site 264732000838 metal binding site [ion binding]; metal-binding site 264732000839 metal binding site [ion binding]; metal-binding site 264732000840 putative Cl binding site [ion binding]; other site 264732000841 aspartate ring; other site 264732000842 basic sphincter; other site 264732000843 hydrophobic gate; other site 264732000844 periplasmic entrance; other site 264732000845 Protein of unknown function DUF72; Region: DUF72; pfam01904 264732000846 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264732000847 Preprotein translocase SecG subunit; Region: SecG; pfam03840 264732000848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732000849 Zn2+ binding site [ion binding]; other site 264732000850 Mg2+ binding site [ion binding]; other site 264732000851 ribonuclease R; Region: RNase_R; TIGR02063 264732000852 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264732000853 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264732000854 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 264732000855 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264732000856 RNA binding site [nucleotide binding]; other site 264732000857 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 264732000858 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264732000859 SmpB-tmRNA interface; other site 264732000860 Domain of unknown function (DUF955); Region: DUF955; pfam06114 264732000861 transcriptional repressor DicA; Reviewed; Region: PRK09706 264732000862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000863 non-specific DNA binding site [nucleotide binding]; other site 264732000864 salt bridge; other site 264732000865 sequence-specific DNA binding site [nucleotide binding]; other site 264732000866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732000867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000868 non-specific DNA binding site [nucleotide binding]; other site 264732000869 salt bridge; other site 264732000870 sequence-specific DNA binding site [nucleotide binding]; other site 264732000871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732000872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000873 non-specific DNA binding site [nucleotide binding]; other site 264732000874 salt bridge; other site 264732000875 sequence-specific DNA binding site [nucleotide binding]; other site 264732000876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000877 non-specific DNA binding site [nucleotide binding]; other site 264732000878 salt bridge; other site 264732000879 sequence-specific DNA binding site [nucleotide binding]; other site 264732000880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 264732000881 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264732000882 DNA binding residues [nucleotide binding] 264732000883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000884 non-specific DNA binding site [nucleotide binding]; other site 264732000885 salt bridge; other site 264732000886 sequence-specific DNA binding site [nucleotide binding]; other site 264732000887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000888 non-specific DNA binding site [nucleotide binding]; other site 264732000889 salt bridge; other site 264732000890 sequence-specific DNA binding site [nucleotide binding]; other site 264732000891 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264732000892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 264732000893 DNA binding residues [nucleotide binding] 264732000894 transposase; Provisional; Region: PRK06526 264732000895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000896 Walker A motif; other site 264732000897 ATP binding site [chemical binding]; other site 264732000898 Walker B motif; other site 264732000899 arginine finger; other site 264732000900 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 264732000901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264732000902 DNA-binding interface [nucleotide binding]; DNA binding site 264732000903 Integrase core domain; Region: rve; pfam00665 264732000904 Integrase core domain; Region: rve_3; cl15866 264732000905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000906 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732000907 Walker A motif; other site 264732000908 ATP binding site [chemical binding]; other site 264732000909 Walker B motif; other site 264732000910 arginine finger; other site 264732000911 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 264732000912 catalytic residues [active] 264732000913 putative transposase OrfB; Reviewed; Region: PHA02517 264732000914 HTH-like domain; Region: HTH_21; pfam13276 264732000915 Integrase core domain; Region: rve; pfam00665 264732000916 Integrase core domain; Region: rve_3; pfam13683 264732000917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732000918 Transposase; Region: HTH_Tnp_1; cl17663 264732000919 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 264732000920 active site 264732000921 recombinase A; Provisional; Region: recA; PRK09354 264732000922 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264732000923 hexamer interface [polypeptide binding]; other site 264732000924 Walker A motif; other site 264732000925 ATP binding site [chemical binding]; other site 264732000926 Walker B motif; other site 264732000927 Domain of unknown function (DUF955); Region: DUF955; pfam06114 264732000928 YcfA-like protein; Region: YcfA; cl00752 264732000929 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 264732000930 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732000931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732000932 non-specific DNA binding site [nucleotide binding]; other site 264732000933 salt bridge; other site 264732000934 sequence-specific DNA binding site [nucleotide binding]; other site 264732000935 Helix-turn-helix domain; Region: HTH_31; pfam13560 264732000936 non-specific DNA binding site [nucleotide binding]; other site 264732000937 salt bridge; other site 264732000938 sequence-specific DNA binding site [nucleotide binding]; other site 264732000939 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 264732000940 glycoprotein BALF4; Provisional; Region: PHA03231 264732000941 TcpE family; Region: TcpE; pfam12648 264732000942 AAA-like domain; Region: AAA_10; pfam12846 264732000943 Alpha-helical domain 2; Region: alpha-hel2; cl19908 264732000944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732000945 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732000946 Walker A motif; other site 264732000947 ATP binding site [chemical binding]; other site 264732000948 Walker B motif; other site 264732000949 arginine finger; other site 264732000950 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 264732000951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264732000952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264732000953 catalytic residue [active] 264732000954 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732000955 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732000956 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264732000957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732000958 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 264732000959 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 264732000960 S-layer homology domain; Region: SLH; pfam00395 264732000961 Peptidase family M41; Region: Peptidase_M41; pfam01434 264732000962 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264732000963 Walker A motif; other site 264732000964 ATP binding site [chemical binding]; other site 264732000965 Walker B motif; other site 264732000966 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 264732000967 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048 264732000968 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264732000969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 264732000970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732000971 phosphorylation site [posttranslational modification] 264732000972 intermolecular recognition site; other site 264732000973 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 264732000974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 264732000975 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264732000976 P-loop; other site 264732000977 Magnesium ion binding site [ion binding]; other site 264732000978 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 264732000979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732000980 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 264732000981 putative active site [active] 264732000982 redox center [active] 264732000983 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 264732000984 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264732000985 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264732000986 Protein of unknown function (DUF515); Region: DUF515; cl19548 264732000987 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264732000988 Walker A motif; other site 264732000989 ATP binding site [chemical binding]; other site 264732000990 Walker B motif; other site 264732000991 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 264732000992 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264732000993 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 264732000994 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 264732000995 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 264732000996 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 264732000997 Mg binding site [ion binding]; other site 264732000998 nucleotide binding site [chemical binding]; other site 264732000999 putative protofilament interface [polypeptide binding]; other site 264732001000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264732001001 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; cl19358 264732001002 Helix-turn-helix domain; Region: HTH_36; pfam13730 264732001003 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264732001004 active site 264732001005 metal binding site [ion binding]; metal-binding site 264732001006 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264732001007 DNA topoisomerase; Region: Topoisom_bac; pfam01131 264732001008 DNA binding groove [nucleotide binding] 264732001009 domain I; other site 264732001010 phosphate binding site [ion binding]; other site 264732001011 domain II; other site 264732001012 domain III; other site 264732001013 nucleotide binding site [chemical binding]; other site 264732001014 catalytic site [active] 264732001015 domain IV; other site 264732001016 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264732001017 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264732001018 Bacitracin resistance protein BacA; Region: BacA; cl00858 264732001019 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264732001020 RNA binding site [nucleotide binding]; other site 264732001021 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 264732001022 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 264732001023 RNA binding site [nucleotide binding]; other site 264732001024 PemK-like protein; Region: PemK; pfam02452 264732001025 Domain of unknown function (DUF955); Region: DUF955; cl01076 264732001026 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264732001027 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264732001028 active site 264732001029 metal binding site [ion binding]; metal-binding site 264732001030 interdomain interaction site; other site 264732001031 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 264732001032 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 264732001033 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264732001034 active site 264732001035 catalytic residues [active] 264732001036 DNA binding site [nucleotide binding] 264732001037 Int/Topo IB signature motif; other site 264732001038 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 264732001039 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 264732001040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732001041 non-specific DNA binding site [nucleotide binding]; other site 264732001042 salt bridge; other site 264732001043 sequence-specific DNA binding site [nucleotide binding]; other site 264732001044 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 264732001045 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264732001046 Walker A motif; other site 264732001047 ATP binding site [chemical binding]; other site 264732001048 Walker B motif; other site 264732001049 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 264732001050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001051 FeS/SAM binding site; other site 264732001052 Probable zinc-binding domain; Region: zf-trcl; pfam13451 264732001053 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 264732001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 264732001055 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264732001056 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 264732001057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732001058 putative DNA binding site [nucleotide binding]; other site 264732001059 dimerization interface [polypeptide binding]; other site 264732001060 putative Zn2+ binding site [ion binding]; other site 264732001061 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264732001062 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264732001063 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264732001064 Bacterial transcriptional regulator; Region: IclR; pfam01614 264732001065 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264732001066 Ferredoxin [Energy production and conversion]; Region: COG1146 264732001067 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732001068 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 264732001069 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732001070 dimer interface [polypeptide binding]; other site 264732001071 PYR/PP interface [polypeptide binding]; other site 264732001072 TPP binding site [chemical binding]; other site 264732001073 substrate binding site [chemical binding]; other site 264732001074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264732001075 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 264732001076 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 264732001077 TPP-binding site [chemical binding]; other site 264732001078 putative dimer interface [polypeptide binding]; other site 264732001079 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264732001080 CoA binding domain; Region: CoA_binding_2; pfam13380 264732001081 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264732001082 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 264732001083 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264732001084 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 264732001085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264732001086 anion transporter; Region: dass; TIGR00785 264732001087 transmembrane helices; other site 264732001088 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264732001089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264732001090 dimer interface [polypeptide binding]; other site 264732001091 putative CheW interface [polypeptide binding]; other site 264732001092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 264732001093 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264732001094 substrate binding pocket [chemical binding]; other site 264732001095 dimer interface [polypeptide binding]; other site 264732001096 inhibitor binding site; inhibition site 264732001097 CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308 264732001098 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732001099 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264732001100 B12 binding site [chemical binding]; other site 264732001101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732001102 Mg2+ binding site [ion binding]; other site 264732001103 G-X-G motif; other site 264732001104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732001105 Transposase; Region: HTH_Tnp_1; cl17663 264732001106 putative transposase OrfB; Reviewed; Region: PHA02517 264732001107 HTH-like domain; Region: HTH_21; pfam13276 264732001108 Integrase core domain; Region: rve; pfam00665 264732001109 Integrase core domain; Region: rve_3; pfam13683 264732001110 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264732001111 anti sigma factor interaction site; other site 264732001112 regulatory phosphorylation site [posttranslational modification]; other site 264732001113 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264732001114 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264732001115 anti sigma factor interaction site; other site 264732001116 regulatory phosphorylation site [posttranslational modification]; other site 264732001117 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264732001118 Predicted membrane protein [Function unknown]; Region: COG2119 264732001119 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264732001120 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264732001121 sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Region: sucrsPsyn_pln; TIGR02468 264732001122 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264732001123 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 264732001124 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 264732001125 CoA binding domain; Region: CoA_binding; smart00881 264732001126 CoA-ligase; Region: Ligase_CoA; pfam00549 264732001127 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264732001128 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 264732001129 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264732001130 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264732001131 putative NAD(P) binding site [chemical binding]; other site 264732001132 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264732001133 CoenzymeA binding site [chemical binding]; other site 264732001134 subunit interaction site [polypeptide binding]; other site 264732001135 PHB binding site; other site 264732001136 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090 264732001137 glycerate kinase; Region: TIGR00045 264732001138 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 264732001139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732001140 dimer interface [polypeptide binding]; other site 264732001141 conserved gate region; other site 264732001142 putative PBP binding loops; other site 264732001143 ABC-ATPase subunit interface; other site 264732001144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732001145 dimer interface [polypeptide binding]; other site 264732001146 conserved gate region; other site 264732001147 putative PBP binding loops; other site 264732001148 ABC-ATPase subunit interface; other site 264732001149 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264732001150 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264732001151 Walker A/P-loop; other site 264732001152 ATP binding site [chemical binding]; other site 264732001153 Q-loop/lid; other site 264732001154 ABC transporter signature motif; other site 264732001155 Walker B; other site 264732001156 D-loop; other site 264732001157 H-loop/switch region; other site 264732001158 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 264732001159 homooctamer interface [polypeptide binding]; other site 264732001160 active site 264732001161 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 264732001162 active site 264732001163 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732001164 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732001165 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 264732001166 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 264732001167 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 264732001168 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732001169 active site 264732001170 NTP binding site [chemical binding]; other site 264732001171 metal binding triad [ion binding]; metal-binding site 264732001172 antibiotic binding site [chemical binding]; other site 264732001173 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264732001174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732001175 putative DNA binding site [nucleotide binding]; other site 264732001176 putative Zn2+ binding site [ion binding]; other site 264732001177 Bacterial transcriptional regulator; Region: IclR; pfam01614 264732001178 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 264732001179 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 264732001180 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264732001181 substrate binding site [chemical binding]; other site 264732001182 ATP binding site [chemical binding]; other site 264732001183 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264732001184 Entner-Doudoroff aldolase; Region: eda; TIGR01182 264732001185 active site 264732001186 intersubunit interface [polypeptide binding]; other site 264732001187 catalytic residue [active] 264732001188 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732001189 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 264732001190 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264732001191 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264732001192 nucleotide binding site [chemical binding]; other site 264732001193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 264732001194 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264732001195 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 264732001196 DctM-like transporters; Region: DctM; pfam06808 264732001197 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 264732001198 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 264732001199 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264732001200 classical (c) SDRs; Region: SDR_c; cd05233 264732001201 NAD(P) binding site [chemical binding]; other site 264732001202 active site 264732001203 Glucuronate isomerase; Region: UxaC; pfam02614 264732001204 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264732001205 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 264732001206 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 264732001207 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 264732001208 mannonate dehydratase; Provisional; Region: PRK03906 264732001209 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 264732001210 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 264732001211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732001212 dimerization interface [polypeptide binding]; other site 264732001213 putative DNA binding site [nucleotide binding]; other site 264732001214 putative Zn2+ binding site [ion binding]; other site 264732001215 DsrE/DsrF-like family; Region: DrsE; cl00672 264732001216 DsrE/DsrF-like family; Region: DrsE; cl00672 264732001217 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 264732001218 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264732001219 CPxP motif; other site 264732001220 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 264732001221 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264732001222 lipoyl attachment site [posttranslational modification]; other site 264732001223 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732001224 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264732001225 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 264732001226 Cysteine-rich domain; Region: CCG; pfam02754 264732001227 Cysteine-rich domain; Region: CCG; pfam02754 264732001228 Ferredoxin [Energy production and conversion]; Region: COG1146 264732001229 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732001230 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732001231 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732001232 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 264732001233 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264732001234 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 264732001235 Protein of unknown function DUF116; Region: DUF116; pfam01976 264732001236 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 264732001237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732001238 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 264732001239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001240 FeS/SAM binding site; other site 264732001241 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 264732001242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001243 FeS/SAM binding site; other site 264732001244 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 264732001245 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264732001246 CPxP motif; other site 264732001247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264732001248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264732001249 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264732001250 putative dimerization interface [polypeptide binding]; other site 264732001251 Sulphur transport; Region: Sulf_transp; cl19477 264732001252 Sulphur transport; Region: Sulf_transp; cl19477 264732001253 thiosulfate reductase PhsA; Provisional; Region: PRK15488 264732001254 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 264732001255 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 264732001256 putative [Fe4-S4] binding site [ion binding]; other site 264732001257 putative molybdopterin cofactor binding site [chemical binding]; other site 264732001258 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 264732001259 putative molybdopterin cofactor binding site; other site 264732001260 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264732001261 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732001262 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264732001263 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264732001264 Ligand binding site; other site 264732001265 Putative Catalytic site; other site 264732001266 DXD motif; other site 264732001267 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 264732001268 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264732001269 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264732001270 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 264732001271 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264732001272 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 264732001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001274 FeS/SAM binding site; other site 264732001275 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 264732001276 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264732001277 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 264732001278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264732001279 ligand binding site [chemical binding]; other site 264732001280 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264732001281 cytosine deaminase; Provisional; Region: PRK05985 264732001282 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 264732001283 active site 264732001284 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264732001285 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264732001286 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 264732001287 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264732001288 active site 264732001289 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 264732001290 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264732001291 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 264732001292 active site 264732001293 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 264732001294 putative active site [active] 264732001295 metal binding site [ion binding]; metal-binding site 264732001296 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264732001297 NMT1-like family; Region: NMT1_2; pfam13379 264732001298 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264732001299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732001300 dimer interface [polypeptide binding]; other site 264732001301 conserved gate region; other site 264732001302 putative PBP binding loops; other site 264732001303 ABC-ATPase subunit interface; other site 264732001304 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264732001305 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264732001306 Walker A/P-loop; other site 264732001307 ATP binding site [chemical binding]; other site 264732001308 Q-loop/lid; other site 264732001309 ABC transporter signature motif; other site 264732001310 Walker B; other site 264732001311 D-loop; other site 264732001312 H-loop/switch region; other site 264732001313 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264732001314 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264732001315 putative dimer interface [polypeptide binding]; other site 264732001316 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 264732001317 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 264732001318 putative active site; other site 264732001319 catalytic residue [active] 264732001320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264732001321 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 264732001322 putative NAD(P) binding site [chemical binding]; other site 264732001323 catalytic Zn binding site [ion binding]; other site 264732001324 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 264732001325 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 264732001326 N- and C-terminal domain interface [polypeptide binding]; other site 264732001327 putative active site [active] 264732001328 MgATP binding site [chemical binding]; other site 264732001329 catalytic site [active] 264732001330 metal binding site [ion binding]; metal-binding site 264732001331 putative xylulose binding site [chemical binding]; other site 264732001332 putative homodimer interface [polypeptide binding]; other site 264732001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732001334 D-galactonate transporter; Region: 2A0114; TIGR00893 264732001335 putative substrate translocation pore; other site 264732001336 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264732001337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732001338 putative DNA binding site [nucleotide binding]; other site 264732001339 putative Zn2+ binding site [ion binding]; other site 264732001340 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264732001341 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264732001342 active site 264732001343 metal binding site [ion binding]; metal-binding site 264732001344 DNA binding site [nucleotide binding] 264732001345 Uncharacterized conserved protein [Function unknown]; Region: COG4717 264732001346 AAA domain; Region: AAA_23; pfam13476 264732001347 Walker A/P-loop; other site 264732001348 ATP binding site [chemical binding]; other site 264732001349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732001350 ABC transporter signature motif; other site 264732001351 Walker B; other site 264732001352 D-loop; other site 264732001353 H-loop/switch region; other site 264732001354 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 264732001355 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264732001356 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 264732001357 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 264732001358 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264732001359 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264732001360 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 264732001361 YcfA-like protein; Region: YcfA; cl00752 264732001362 Domain of unknown function (DUF955); Region: DUF955; cl01076 264732001363 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 264732001364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 264732001365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264732001366 Walker A/P-loop; other site 264732001367 ATP binding site [chemical binding]; other site 264732001368 Q-loop/lid; other site 264732001369 ABC transporter signature motif; other site 264732001370 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 264732001371 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 264732001372 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 264732001373 active site 264732001374 metal binding site [ion binding]; metal-binding site 264732001375 interdomain interaction site; other site 264732001376 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 264732001377 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 264732001378 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 264732001379 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 264732001380 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 264732001381 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 264732001382 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 264732001383 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 264732001384 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 264732001385 Predicted transcriptional regulator [Transcription]; Region: COG2378 264732001386 HTH domain; Region: HTH_11; cl17392 264732001387 WYL domain; Region: WYL; pfam13280 264732001388 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264732001389 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 264732001390 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 264732001391 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264732001392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264732001393 dimer interface [polypeptide binding]; other site 264732001394 putative CheW interface [polypeptide binding]; other site 264732001395 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 264732001396 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264732001397 acyl-activating enzyme (AAE) consensus motif; other site 264732001398 putative AMP binding site [chemical binding]; other site 264732001399 putative active site [active] 264732001400 putative CoA binding site [chemical binding]; other site 264732001401 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732001402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732001403 Zn2+ binding site [ion binding]; other site 264732001404 Mg2+ binding site [ion binding]; other site 264732001405 D-aminoacyl-tRNA deacylase; Region: tRNA_deacylase; cl00716 264732001406 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732001407 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732001408 epoxyqueuosine reductase; Region: TIGR00276 264732001409 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264732001410 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 264732001411 HEAT repeats; Region: HEAT_2; pfam13646 264732001412 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 264732001413 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 264732001414 PrkA AAA domain; Region: AAA_PrkA; smart00763 264732001415 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 264732001416 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 264732001417 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264732001418 metal ion-dependent adhesion site (MIDAS); other site 264732001419 SpoVR like protein; Region: SpoVR; pfam04293 264732001420 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264732001421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264732001422 acyl-activating enzyme (AAE) consensus motif; other site 264732001423 AMP binding site [chemical binding]; other site 264732001424 active site 264732001425 CoA binding site [chemical binding]; other site 264732001426 ACT domain-containing protein [General function prediction only]; Region: COG4747 264732001427 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 264732001428 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 264732001429 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 264732001430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732001431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732001432 homodimer interface [polypeptide binding]; other site 264732001433 catalytic residue [active] 264732001434 Sporulation and spore germination; Region: Germane; pfam10646 264732001435 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732001436 Bacterial SH3 domain; Region: SH3_3; pfam08239 264732001437 AMIN domain; Region: AMIN; pfam11741 264732001438 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264732001439 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264732001440 active site 264732001441 metal binding site [ion binding]; metal-binding site 264732001442 glutamate racemase; Provisional; Region: PRK00865 264732001443 ribonuclease PH; Reviewed; Region: rph; PRK00173 264732001444 Ribonuclease PH; Region: RNase_PH_bact; cd11362 264732001445 hexamer interface [polypeptide binding]; other site 264732001446 active site 264732001447 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264732001448 active site 264732001449 dimerization interface [polypeptide binding]; other site 264732001450 FOG: CBS domain [General function prediction only]; Region: COG0517 264732001451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc2; cd04599 264732001452 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732001453 metal binding site [ion binding]; metal-binding site 264732001454 active site 264732001455 I-site; other site 264732001456 Uncharacterized conserved protein [Function unknown]; Region: COG5134 264732001457 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732001458 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 264732001459 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 264732001460 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 264732001461 trigger factor; Provisional; Region: tig; PRK01490 264732001462 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 264732001463 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264732001464 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264732001465 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264732001466 oligomer interface [polypeptide binding]; other site 264732001467 active site residues [active] 264732001468 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264732001469 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 264732001470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732001471 Walker A motif; other site 264732001472 ATP binding site [chemical binding]; other site 264732001473 Walker B motif; other site 264732001474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264732001475 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 264732001476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732001477 Walker A motif; other site 264732001478 ATP binding site [chemical binding]; other site 264732001479 Walker B motif; other site 264732001480 arginine finger; other site 264732001481 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264732001482 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264732001483 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 264732001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732001485 Walker A motif; other site 264732001486 ATP binding site [chemical binding]; other site 264732001487 Walker B motif; other site 264732001488 arginine finger; other site 264732001489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264732001490 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264732001491 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264732001492 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264732001493 active site 264732001494 HIGH motif; other site 264732001495 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264732001496 KMSKS motif; other site 264732001497 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264732001498 tRNA binding surface [nucleotide binding]; other site 264732001499 anticodon binding site; other site 264732001500 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264732001501 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 264732001502 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732001503 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264732001504 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 264732001505 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 264732001506 CoA binding domain; Region: CoA_binding; pfam02629 264732001507 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264732001508 active site 264732001509 dimer interface [polypeptide binding]; other site 264732001510 hypothetical protein; Reviewed; Region: PRK00024 264732001511 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264732001512 MPN+ (JAMM) motif; other site 264732001513 Zinc-binding site [ion binding]; other site 264732001514 rod shape-determining protein MreB; Provisional; Region: PRK13927 264732001515 MreB and similar proteins; Region: MreB_like; cd10225 264732001516 nucleotide binding site [chemical binding]; other site 264732001517 Mg binding site [ion binding]; other site 264732001518 putative protofilament interaction site [polypeptide binding]; other site 264732001519 RodZ interaction site [polypeptide binding]; other site 264732001520 rod shape-determining protein MreC; Provisional; Region: PRK13922 264732001521 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 264732001522 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264732001523 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 264732001524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264732001525 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264732001526 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 264732001527 septum site-determining protein MinD; Region: minD_bact; TIGR01968 264732001528 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 264732001529 P-loop; other site 264732001530 ADP binding residues [chemical binding]; other site 264732001531 Switch I; other site 264732001532 Switch II; other site 264732001533 Septum formation topological specificity factor MinE; Region: MinE; cl00538 264732001534 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 264732001535 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264732001536 oligomerisation interface [polypeptide binding]; other site 264732001537 mobile loop; other site 264732001538 roof hairpin; other site 264732001539 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 264732001540 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264732001541 ring oligomerisation interface [polypeptide binding]; other site 264732001542 ATP/Mg binding site [chemical binding]; other site 264732001543 stacking interactions; other site 264732001544 hinge regions; other site 264732001545 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264732001546 active site 264732001547 thiamine phosphate binding site [chemical binding]; other site 264732001548 pyrophosphate binding site [ion binding]; other site 264732001549 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732001550 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732001551 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 264732001552 active site 264732001553 Peptidase family M50; Region: Peptidase_M50; pfam02163 264732001554 putative substrate binding region [chemical binding]; other site 264732001555 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 264732001556 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264732001557 nitrogenase vanadium-iron protein, alpha chain; Region: VNFD; TIGR01860 264732001558 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 264732001559 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 264732001560 metal binding site [ion binding]; metal-binding site 264732001561 NAD synthetase; Provisional; Region: PRK13981 264732001562 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 264732001563 multimer interface [polypeptide binding]; other site 264732001564 active site 264732001565 catalytic triad [active] 264732001566 protein interface 1 [polypeptide binding]; other site 264732001567 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264732001568 homodimer interface [polypeptide binding]; other site 264732001569 NAD binding pocket [chemical binding]; other site 264732001570 ATP binding pocket [chemical binding]; other site 264732001571 Mg binding site [ion binding]; other site 264732001572 active-site loop [active] 264732001573 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 264732001574 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 264732001575 B12 binding site [chemical binding]; other site 264732001576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001577 FeS/SAM binding site; other site 264732001578 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 264732001579 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 264732001580 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264732001581 homodimer interface [polypeptide binding]; other site 264732001582 oligonucleotide binding site [chemical binding]; other site 264732001583 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 264732001584 TRAM domain; Region: TRAM; cl01282 264732001585 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264732001586 Protein of unknown function (DUF464); Region: DUF464; pfam04327 264732001587 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264732001588 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 264732001589 GTPase CgtA; Reviewed; Region: obgE; PRK12297 264732001590 GTP1/OBG; Region: GTP1_OBG; pfam01018 264732001591 Obg GTPase; Region: Obg; cd01898 264732001592 G1 box; other site 264732001593 GTP/Mg2+ binding site [chemical binding]; other site 264732001594 Switch I region; other site 264732001595 G2 box; other site 264732001596 G3 box; other site 264732001597 Switch II region; other site 264732001598 G4 box; other site 264732001599 G5 box; other site 264732001600 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 264732001601 gamma-glutamyl kinase; Provisional; Region: PRK05429 264732001602 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264732001603 nucleotide binding site [chemical binding]; other site 264732001604 homotetrameric interface [polypeptide binding]; other site 264732001605 putative phosphate binding site [ion binding]; other site 264732001606 putative allosteric binding site; other site 264732001607 PUA domain; Region: PUA; pfam01472 264732001608 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264732001609 putative catalytic cysteine [active] 264732001610 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264732001611 active site 264732001612 (T/H)XGH motif; other site 264732001613 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 264732001614 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 264732001615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732001616 Zn2+ binding site [ion binding]; other site 264732001617 Mg2+ binding site [ion binding]; other site 264732001618 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 264732001619 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264732001620 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264732001621 active site 264732001622 HIGH motif; other site 264732001623 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264732001624 KMSKS motif; other site 264732001625 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264732001626 tRNA binding surface [nucleotide binding]; other site 264732001627 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264732001628 transmembrane helices; other site 264732001629 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 264732001630 SLBB domain; Region: SLBB; pfam10531 264732001631 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264732001632 Bacitracin resistance protein BacA; Region: BacA; pfam02673 264732001633 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 264732001634 heme-binding site [chemical binding]; other site 264732001635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 264732001636 putative CheW interface [polypeptide binding]; other site 264732001637 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 264732001638 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264732001639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732001640 S-adenosylmethionine binding site [chemical binding]; other site 264732001641 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 264732001642 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 264732001643 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 264732001644 Competence protein; Region: Competence; pfam03772 264732001645 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 264732001646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 264732001647 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 264732001648 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 264732001649 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264732001650 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 264732001651 stage II sporulation protein P; Region: spore_II_P; TIGR02867 264732001652 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 264732001653 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264732001654 AIR carboxylase; Region: AIRC; smart01001 264732001655 Membrane protein of unknown function; Region: DUF360; pfam04020 264732001656 GTP-binding protein LepA; Provisional; Region: PRK05433 264732001657 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264732001658 G1 box; other site 264732001659 putative GEF interaction site [polypeptide binding]; other site 264732001660 GTP/Mg2+ binding site [chemical binding]; other site 264732001661 Switch I region; other site 264732001662 G2 box; other site 264732001663 G3 box; other site 264732001664 Switch II region; other site 264732001665 G4 box; other site 264732001666 G5 box; other site 264732001667 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264732001668 Elongation Factor G, domain II; Region: EFG_II; pfam14492 264732001669 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264732001670 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264732001671 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 264732001672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001673 FeS/SAM binding site; other site 264732001674 HemN C-terminal domain; Region: HemN_C; pfam06969 264732001675 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 264732001676 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 264732001677 HrcA protein C terminal domain; Region: HrcA; pfam01628 264732001678 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264732001679 dimer interface [polypeptide binding]; other site 264732001680 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264732001681 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264732001682 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 264732001683 nucleotide binding site [chemical binding]; other site 264732001684 NEF interaction site [polypeptide binding]; other site 264732001685 SBD interface [polypeptide binding]; other site 264732001686 chaperone protein DnaJ; Provisional; Region: PRK10767 264732001687 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264732001688 HSP70 interaction site [polypeptide binding]; other site 264732001689 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264732001690 substrate binding site [polypeptide binding]; other site 264732001691 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264732001692 Zn binding sites [ion binding]; other site 264732001693 dimer interface [polypeptide binding]; other site 264732001694 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 264732001695 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 264732001696 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264732001697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732001698 FeS/SAM binding site; other site 264732001699 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 264732001700 nucleotide binding site/active site [active] 264732001701 HIT family signature motif; other site 264732001702 catalytic residue [active] 264732001703 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 264732001704 YabP family; Region: YabP; cl06766 264732001705 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 264732001706 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 264732001707 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264732001708 PhoH-like protein; Region: PhoH; pfam02562 264732001709 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 264732001710 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 264732001711 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 264732001712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732001713 Zn2+ binding site [ion binding]; other site 264732001714 Mg2+ binding site [ion binding]; other site 264732001715 metal-binding heat shock protein; Provisional; Region: PRK00016 264732001716 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 264732001717 trimer interface [polypeptide binding]; other site 264732001718 putative active site [active] 264732001719 Zn binding site [ion binding]; other site 264732001720 Uncharacterized conserved protein [Function unknown]; Region: COG2928 264732001721 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 264732001722 nudix motif; other site 264732001723 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 264732001724 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 264732001725 active site 264732001726 catalytic motif [active] 264732001727 Zn binding site [ion binding]; other site 264732001728 GTPase Era; Reviewed; Region: era; PRK00089 264732001729 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264732001730 G1 box; other site 264732001731 GTP/Mg2+ binding site [chemical binding]; other site 264732001732 Switch I region; other site 264732001733 G2 box; other site 264732001734 Switch II region; other site 264732001735 G3 box; other site 264732001736 G4 box; other site 264732001737 G5 box; other site 264732001738 KH domain; Region: KH_2; pfam07650 264732001739 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 264732001740 Recombination protein O N terminal; Region: RecO_N; pfam11967 264732001741 Recombination protein O C terminal; Region: RecO_C; pfam02565 264732001742 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 264732001743 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264732001744 dimer interface [polypeptide binding]; other site 264732001745 motif 1; other site 264732001746 active site 264732001747 motif 2; other site 264732001748 motif 3; other site 264732001749 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 264732001750 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 264732001751 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264732001752 HTH domain; Region: HTH_11; pfam08279 264732001753 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 264732001754 FOG: CBS domain [General function prediction only]; Region: COG0517 264732001755 PEP synthetase regulatory protein; Provisional; Region: PRK05339 264732001756 pyruvate phosphate dikinase; Provisional; Region: PRK09279 264732001757 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264732001758 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264732001759 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264732001760 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264732001761 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264732001762 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264732001763 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264732001764 intersubunit interface [polypeptide binding]; other site 264732001765 active site 264732001766 zinc binding site [ion binding]; other site 264732001767 Na+ binding site [ion binding]; other site 264732001768 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 264732001769 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 264732001770 dimer interface [polypeptide binding]; other site 264732001771 active site 264732001772 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 264732001773 dimer interface [polypeptide binding]; other site 264732001774 active site 264732001775 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 264732001776 putative substrate binding site [chemical binding]; other site 264732001777 putative ATP binding site [chemical binding]; other site 264732001778 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 264732001779 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264732001780 putative ligand binding site [chemical binding]; other site 264732001781 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264732001782 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264732001783 Walker A/P-loop; other site 264732001784 ATP binding site [chemical binding]; other site 264732001785 Q-loop/lid; other site 264732001786 ABC transporter signature motif; other site 264732001787 Walker B; other site 264732001788 D-loop; other site 264732001789 H-loop/switch region; other site 264732001790 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264732001791 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264732001792 TM-ABC transporter signature motif; other site 264732001793 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264732001794 substrate binding site [chemical binding]; other site 264732001795 ATP binding site [chemical binding]; other site 264732001796 Uncharacterized conserved protein [Function unknown]; Region: COG1683 264732001797 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 264732001798 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 264732001799 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264732001800 active site 264732001801 RNA/DNA hybrid binding site [nucleotide binding]; other site 264732001802 Rubredoxin [Energy production and conversion]; Region: COG1773 264732001803 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264732001804 iron binding site [ion binding]; other site 264732001805 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264732001806 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 264732001807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732001808 Zn2+ binding site [ion binding]; other site 264732001809 Mg2+ binding site [ion binding]; other site 264732001810 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264732001811 DNA primase; Validated; Region: dnaG; PRK05667 264732001812 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264732001813 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264732001814 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264732001815 active site 264732001816 metal binding site [ion binding]; metal-binding site 264732001817 interdomain interaction site; other site 264732001818 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264732001819 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 264732001820 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264732001821 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264732001822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732001823 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264732001824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732001825 DNA binding residues [nucleotide binding] 264732001826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264732001827 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 264732001828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 264732001829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 264732001830 Transposase, Mutator family; Region: Transposase_mut; cl19537 264732001831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264732001832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264732001833 DNA binding site [nucleotide binding] 264732001834 domain linker motif; other site 264732001835 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264732001836 dimerization interface [polypeptide binding]; other site 264732001837 ligand binding site [chemical binding]; other site 264732001838 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 264732001839 inhibitor site; inhibition site 264732001840 active site 264732001841 dimer interface [polypeptide binding]; other site 264732001842 catalytic residue [active] 264732001843 benzoate transport; Region: 2A0115; TIGR00895 264732001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732001845 putative substrate translocation pore; other site 264732001846 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 264732001847 active site 264732001848 substrate-binding site [chemical binding]; other site 264732001849 metal-binding site [ion binding] 264732001850 ATP binding site [chemical binding]; other site 264732001851 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 264732001852 active site 264732001853 NTP binding site [chemical binding]; other site 264732001854 metal binding triad [ion binding]; metal-binding site 264732001855 DNA methylase; Region: N6_N4_Mtase; cl17433 264732001856 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 264732001857 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264732001858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732001859 ATP binding site [chemical binding]; other site 264732001860 putative Mg++ binding site [ion binding]; other site 264732001861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732001862 nucleotide binding region [chemical binding]; other site 264732001863 ATP-binding site [chemical binding]; other site 264732001864 PglZ domain; Region: PglZ; pfam08665 264732001865 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 264732001866 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 264732001867 transposase; Provisional; Region: PRK06526 264732001868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732001869 Walker A motif; other site 264732001870 ATP binding site [chemical binding]; other site 264732001871 Walker B motif; other site 264732001872 arginine finger; other site 264732001873 putative transposase OrfB; Reviewed; Region: PHA02517 264732001874 HTH-like domain; Region: HTH_21; pfam13276 264732001875 Integrase core domain; Region: rve; pfam00665 264732001876 Integrase core domain; Region: rve_3; pfam13683 264732001877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732001878 Transposase; Region: HTH_Tnp_1; cl17663 264732001879 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 264732001880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264732001881 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264732001882 DNA-binding interface [nucleotide binding]; DNA binding site 264732001883 Integrase core domain; Region: rve; pfam00665 264732001884 Integrase core domain; Region: rve_3; cl15866 264732001885 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264732001886 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264732001887 PIN domain; Region: PIN_3; cl17397 264732001888 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264732001889 S-layer homology domain; Region: SLH; pfam00395 264732001890 S-layer homology domain; Region: SLH; pfam00395 264732001891 S-layer homology domain; Region: SLH; pfam00395 264732001892 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 264732001893 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 264732001894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264732001895 DNA-binding interface [nucleotide binding]; DNA binding site 264732001896 Integrase core domain; Region: rve; pfam00665 264732001897 Integrase core domain; Region: rve_3; cl15866 264732001898 transposase; Provisional; Region: PRK06526 264732001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732001900 Walker A motif; other site 264732001901 ATP binding site [chemical binding]; other site 264732001902 Walker B motif; other site 264732001903 arginine finger; other site 264732001904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732001905 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264732001906 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 264732001907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 264732001908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732001909 putative homodimer interface [polypeptide binding]; other site 264732001910 conserved hypothetical integral membrane protein; Region: TIGR03766 264732001911 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 264732001912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732001913 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 264732001914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732001915 putative ADP-binding pocket [chemical binding]; other site 264732001916 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 264732001917 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264732001918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264732001919 Coenzyme A binding pocket [chemical binding]; other site 264732001920 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 264732001921 nad+ binding pocket [chemical binding]; other site 264732001922 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 264732001923 Preprotein binding site; other site 264732001924 SecA binding site; other site 264732001925 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 264732001926 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264732001927 NAD binding site [chemical binding]; other site 264732001928 homodimer interface [polypeptide binding]; other site 264732001929 active site 264732001930 substrate binding site [chemical binding]; other site 264732001931 DNA helicase, putative; Region: TIGR00376 264732001932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264732001933 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 264732001934 AAA domain; Region: AAA_12; pfam13087 264732001935 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 264732001936 PLD-like domain; Region: PLDc_2; pfam13091 264732001937 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264732001938 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264732001939 WYL domain; Region: WYL; pfam13280 264732001940 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264732001941 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264732001942 oligomeric interface; other site 264732001943 putative active site [active] 264732001944 homodimer interface [polypeptide binding]; other site 264732001945 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732001946 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732001947 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 264732001948 PIN domain; Region: PIN; pfam01850 264732001949 putative active site [active] 264732001950 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264732001951 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264732001952 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 264732001953 putative active site [active] 264732001954 PAS fold; Region: PAS_4; pfam08448 264732001955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732001956 putative active site [active] 264732001957 heme pocket [chemical binding]; other site 264732001958 PAS domain S-box; Region: sensory_box; TIGR00229 264732001959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732001960 putative active site [active] 264732001961 heme pocket [chemical binding]; other site 264732001962 PAS domain S-box; Region: sensory_box; TIGR00229 264732001963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732001964 putative active site [active] 264732001965 heme pocket [chemical binding]; other site 264732001966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732001967 metal binding site [ion binding]; metal-binding site 264732001968 active site 264732001969 I-site; other site 264732001970 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732001971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732001972 Zn2+ binding site [ion binding]; other site 264732001973 Mg2+ binding site [ion binding]; other site 264732001974 Uncharacterized conserved protein [Function unknown]; Region: COG3287 264732001975 FIST N domain; Region: FIST; pfam08495 264732001976 FIST C domain; Region: FIST_C; pfam10442 264732001977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732001978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732001979 active site 264732001980 phosphorylation site [posttranslational modification] 264732001981 intermolecular recognition site; other site 264732001982 dimerization interface [polypeptide binding]; other site 264732001983 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 264732001984 metal binding site [ion binding]; metal-binding site 264732001985 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732001986 VanW like protein; Region: VanW; pfam04294 264732001987 cellulose synthase A [UDP-forming], catalytic subunit; Region: PLN02915 264732001988 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 264732001989 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 264732001990 dimerization interface [polypeptide binding]; other site 264732001991 putative ATP binding site [chemical binding]; other site 264732001992 Putative aldolase; Region: Aldolase_2; pfam10120 264732001993 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264732001994 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264732001995 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264732001996 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 264732001997 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 264732001998 putative ligand binding site [chemical binding]; other site 264732001999 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264732002000 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264732002001 Walker A/P-loop; other site 264732002002 ATP binding site [chemical binding]; other site 264732002003 Q-loop/lid; other site 264732002004 ABC transporter signature motif; other site 264732002005 Walker B; other site 264732002006 D-loop; other site 264732002007 H-loop/switch region; other site 264732002008 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264732002009 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264732002010 TM-ABC transporter signature motif; other site 264732002011 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 264732002012 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 264732002013 intersubunit interface [polypeptide binding]; other site 264732002014 active site 264732002015 Zn2+ binding site [ion binding]; other site 264732002016 5'-methylthioadenosine phosphorylase; Validated; Region: PRK08666 264732002017 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 264732002018 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 264732002019 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 264732002020 homotetramer interface [polypeptide binding]; other site 264732002021 ligand binding site [chemical binding]; other site 264732002022 catalytic site [active] 264732002023 NAD binding site [chemical binding]; other site 264732002024 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264732002025 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732002026 Walker A/P-loop; other site 264732002027 ATP binding site [chemical binding]; other site 264732002028 Q-loop/lid; other site 264732002029 ABC transporter signature motif; other site 264732002030 Walker B; other site 264732002031 D-loop; other site 264732002032 H-loop/switch region; other site 264732002033 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732002034 Walker A/P-loop; other site 264732002035 ATP binding site [chemical binding]; other site 264732002036 Q-loop/lid; other site 264732002037 ABC transporter signature motif; other site 264732002038 Walker B; other site 264732002039 D-loop; other site 264732002040 H-loop/switch region; other site 264732002041 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 264732002042 QueT transporter; Region: QueT; pfam06177 264732002043 peptidase; Reviewed; Region: PRK13004 264732002044 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 264732002045 putative metal binding site [ion binding]; other site 264732002046 putative dimer interface [polypeptide binding]; other site 264732002047 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264732002048 dimer interface [polypeptide binding]; other site 264732002049 catalytic triad [active] 264732002050 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 264732002051 Predicted membrane protein [Function unknown]; Region: COG3462 264732002052 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 264732002053 heat shock protein HtpX; Provisional; Region: PRK02391 264732002054 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 264732002055 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 264732002056 S-layer homology domain; Region: SLH; pfam00395 264732002057 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264732002058 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732002059 active site 264732002060 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 264732002061 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732002062 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 264732002063 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 264732002064 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 264732002065 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 264732002066 MoaE interaction surface [polypeptide binding]; other site 264732002067 MoeB interaction surface [polypeptide binding]; other site 264732002068 thiocarboxylated glycine; other site 264732002069 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264732002070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732002071 Propionate catabolism activator; Region: PrpR_N; pfam06506 264732002072 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264732002073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732002074 putative active site [active] 264732002075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732002076 Walker A motif; other site 264732002077 ATP binding site [chemical binding]; other site 264732002078 Walker B motif; other site 264732002079 arginine finger; other site 264732002080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264732002081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 264732002082 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 264732002083 GntP family permease; Region: GntP_permease; pfam02447 264732002084 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264732002085 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 264732002086 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 264732002087 MIF4G like; Region: MIF4G_like_2; pfam09090 264732002088 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 264732002089 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 264732002090 PemK-like protein; Region: PemK; pfam02452 264732002091 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264732002092 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264732002093 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 264732002094 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 264732002095 competence damage-inducible protein A; Provisional; Region: PRK00549 264732002096 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 264732002097 putative MPT binding site; other site 264732002098 Competence-damaged protein; Region: CinA; pfam02464 264732002099 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264732002100 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264732002101 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264732002102 protein binding site [polypeptide binding]; other site 264732002103 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 264732002104 amino acid transporter; Region: 2A0306; TIGR00909 264732002105 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 264732002106 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732002107 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 264732002108 Zn binding site [ion binding]; other site 264732002109 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 264732002110 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264732002111 NodB motif; other site 264732002112 active site 264732002113 catalytic site [active] 264732002114 metal binding site [ion binding]; metal-binding site 264732002115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732002116 dimerization interface [polypeptide binding]; other site 264732002117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 264732002118 dimer interface [polypeptide binding]; other site 264732002119 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264732002120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264732002121 dimer interface [polypeptide binding]; other site 264732002122 putative CheW interface [polypeptide binding]; other site 264732002123 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 264732002124 putative CheA interaction surface; other site 264732002125 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264732002126 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264732002127 putative binding surface; other site 264732002128 active site 264732002129 P2 response regulator binding domain; Region: P2; pfam07194 264732002130 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264732002131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732002132 ATP binding site [chemical binding]; other site 264732002133 Mg2+ binding site [ion binding]; other site 264732002134 G-X-G motif; other site 264732002135 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264732002136 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264732002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732002138 active site 264732002139 phosphorylation site [posttranslational modification] 264732002140 intermolecular recognition site; other site 264732002141 dimerization interface [polypeptide binding]; other site 264732002142 CheB methylesterase; Region: CheB_methylest; pfam01339 264732002143 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 264732002144 FlgN protein; Region: FlgN; pfam05130 264732002145 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 264732002146 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264732002147 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264732002148 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 264732002149 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264732002150 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264732002151 S-layer homology domain; Region: SLH; pfam00395 264732002152 S-layer homology domain; Region: SLH; pfam00395 264732002153 flagellar assembly protein FliW; Provisional; Region: PRK13285 264732002154 Global regulator protein family; Region: CsrA; pfam02599 264732002155 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264732002156 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 264732002157 NAD binding site [chemical binding]; other site 264732002158 substrate binding site [chemical binding]; other site 264732002159 active site 264732002160 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264732002161 inhibitor-cofactor binding pocket; inhibition site 264732002162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732002163 catalytic residue [active] 264732002164 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 264732002165 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264732002166 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 264732002167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732002168 motif II; other site 264732002169 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 264732002170 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264732002171 active site 264732002172 homodimer interface [polypeptide binding]; other site 264732002173 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 264732002174 NeuB family; Region: NeuB; pfam03102 264732002175 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 264732002176 NeuB binding interface [polypeptide binding]; other site 264732002177 putative substrate binding site [chemical binding]; other site 264732002178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 264732002179 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264732002180 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 264732002181 Substrate binding site; other site 264732002182 metal-binding site 264732002183 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 264732002184 ligand binding site; other site 264732002185 tetramer interface; other site 264732002186 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 264732002187 flagellin; Reviewed; Region: PRK08869 264732002188 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264732002189 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264732002190 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264732002191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 264732002192 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 264732002193 putative active site [active] 264732002194 FlaG protein; Region: FlaG; pfam03646 264732002195 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 264732002196 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 264732002197 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264732002198 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 264732002199 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 264732002200 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 264732002201 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 264732002202 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264732002203 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264732002204 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 264732002205 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 264732002206 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 264732002207 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 264732002208 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 264732002209 FliG N-terminal domain; Region: FliG_N; pfam14842 264732002210 FliG middle domain; Region: FliG_M; pfam14841 264732002211 FliG C-terminal domain; Region: FliG_C; pfam01706 264732002212 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 264732002213 Flagellar assembly protein FliH; Region: FliH; cl19405 264732002214 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 264732002215 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264732002216 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264732002217 Walker A motif/ATP binding site; other site 264732002218 Walker B motif; other site 264732002219 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 264732002220 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264732002221 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 264732002222 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 264732002223 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 264732002224 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264732002225 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264732002226 Flagellar protein (FlbD); Region: FlbD; pfam06289 264732002227 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264732002228 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264732002229 flagellar motor protein MotS; Reviewed; Region: PRK06925 264732002230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264732002231 ligand binding site [chemical binding]; other site 264732002232 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 264732002233 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264732002234 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 264732002235 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 264732002236 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 264732002237 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 264732002238 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 264732002239 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 264732002240 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 264732002241 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 264732002242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732002243 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264732002244 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 264732002245 P-loop; other site 264732002246 PilZ domain; Region: PilZ; pfam07238 264732002247 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 264732002248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732002249 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264732002250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732002251 DNA binding residues [nucleotide binding] 264732002252 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 264732002253 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 264732002254 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264732002255 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 264732002256 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 264732002257 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264732002258 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264732002259 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264732002260 Double zinc ribbon; Region: DZR; pfam12773 264732002261 TPR repeat; Region: TPR_11; pfam13414 264732002262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732002263 binding surface 264732002264 TPR motif; other site 264732002265 TPR repeat; Region: TPR_11; pfam13414 264732002266 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 264732002267 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264732002268 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264732002269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732002270 S-adenosylmethionine binding site [chemical binding]; other site 264732002271 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 264732002272 CheC-like family; Region: CheC; pfam04509 264732002273 CheC-like family; Region: CheC; pfam04509 264732002274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732002275 active site 264732002276 phosphorylation site [posttranslational modification] 264732002277 intermolecular recognition site; other site 264732002278 dimerization interface [polypeptide binding]; other site 264732002279 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 264732002280 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 264732002281 flagellar motor switch protein; Validated; Region: PRK08119 264732002282 CheC-like family; Region: CheC; pfam04509 264732002283 CheC-like family; Region: CheC; pfam04509 264732002284 flagellar motor switch protein FliN; Region: fliN; TIGR02480 264732002285 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 264732002286 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 264732002287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732002288 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264732002289 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732002290 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 264732002291 Cysteine-rich domain; Region: CCG; pfam02754 264732002292 Cysteine-rich domain; Region: CCG; pfam02754 264732002293 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732002294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732002295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264732002296 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732002297 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 264732002298 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732002299 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732002300 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 264732002301 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732002302 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 264732002303 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 264732002304 FAD binding pocket [chemical binding]; other site 264732002305 FAD binding motif [chemical binding]; other site 264732002306 phosphate binding motif [ion binding]; other site 264732002307 beta-alpha-beta structure motif; other site 264732002308 NAD binding pocket [chemical binding]; other site 264732002309 Iron coordination center [ion binding]; other site 264732002310 histidinol-phosphatase; Provisional; Region: PRK07328 264732002311 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 264732002312 active site 264732002313 dimer interface [polypeptide binding]; other site 264732002314 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 264732002315 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264732002316 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 264732002317 Glucose inhibited division protein A; Region: GIDA; pfam01134 264732002318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732002319 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 264732002320 LysE type translocator; Region: LysE; cl00565 264732002321 Protein of unknown function (DUF964); Region: DUF964; pfam06133 264732002322 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264732002323 metal binding site 2 [ion binding]; metal-binding site 264732002324 putative DNA binding helix; other site 264732002325 metal binding site 1 [ion binding]; metal-binding site 264732002326 dimer interface [polypeptide binding]; other site 264732002327 structural Zn2+ binding site [ion binding]; other site 264732002328 Jag N-terminus; Region: Jag_N; pfam14804 264732002329 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264732002330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264732002331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264732002332 ligand binding site [chemical binding]; other site 264732002333 flexible hinge region; other site 264732002334 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 264732002335 putative switch regulator; other site 264732002336 non-specific DNA interactions [nucleotide binding]; other site 264732002337 DNA binding site [nucleotide binding] 264732002338 sequence specific DNA binding site [nucleotide binding]; other site 264732002339 putative cAMP binding site [chemical binding]; other site 264732002340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732002341 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732002342 Walker A motif; other site 264732002343 ATP binding site [chemical binding]; other site 264732002344 Walker B motif; other site 264732002345 arginine finger; other site 264732002346 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 264732002347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264732002348 metal ion-dependent adhesion site (MIDAS); other site 264732002349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732002350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732002351 active site 264732002352 phosphorylation site [posttranslational modification] 264732002353 intermolecular recognition site; other site 264732002354 dimerization interface [polypeptide binding]; other site 264732002355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264732002356 DNA binding site [nucleotide binding] 264732002357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 264732002358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732002359 dimerization interface [polypeptide binding]; other site 264732002360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732002361 putative active site [active] 264732002362 heme pocket [chemical binding]; other site 264732002363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264732002364 dimer interface [polypeptide binding]; other site 264732002365 phosphorylation site [posttranslational modification] 264732002366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732002367 ATP binding site [chemical binding]; other site 264732002368 Mg2+ binding site [ion binding]; other site 264732002369 G-X-G motif; other site 264732002370 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 264732002371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732002372 binding surface 264732002373 TPR motif; other site 264732002374 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264732002375 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 264732002376 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 264732002377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732002378 FeS/SAM binding site; other site 264732002379 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264732002380 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264732002381 nucleotide binding site [chemical binding]; other site 264732002382 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264732002383 cell division protein MraZ; Reviewed; Region: PRK00326 264732002384 MraZ protein; Region: MraZ; pfam02381 264732002385 MraZ protein; Region: MraZ; pfam02381 264732002386 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264732002387 Cell division protein FtsL; Region: FtsL; cl11433 264732002388 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 264732002389 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 264732002390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264732002391 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264732002392 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 264732002393 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264732002394 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264732002395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732002396 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264732002397 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264732002398 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264732002399 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732002400 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264732002401 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264732002402 Mg++ binding site [ion binding]; other site 264732002403 putative catalytic motif [active] 264732002404 putative substrate binding site [chemical binding]; other site 264732002405 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 264732002406 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 264732002407 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732002408 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264732002409 cell division protein FtsW; Region: ftsW; TIGR02614 264732002410 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264732002411 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264732002412 homodimer interface [polypeptide binding]; other site 264732002413 active site 264732002414 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264732002415 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264732002416 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732002417 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264732002418 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 264732002419 FAD binding domain; Region: FAD_binding_4; pfam01565 264732002420 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264732002421 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 264732002422 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264732002423 hinge; other site 264732002424 active site 264732002425 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264732002426 Cell division protein FtsQ; Region: FtsQ; pfam03799 264732002427 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 264732002428 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 264732002429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264732002430 nucleotide binding site [chemical binding]; other site 264732002431 Cell division protein FtsA; Region: FtsA; pfam14450 264732002432 cell division protein FtsZ; Validated; Region: PRK09330 264732002433 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264732002434 nucleotide binding site [chemical binding]; other site 264732002435 SulA interaction site; other site 264732002436 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 264732002437 sporulation sigma factor SigE; Reviewed; Region: PRK08301 264732002438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732002439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732002440 DNA binding residues [nucleotide binding] 264732002441 sporulation sigma factor SigG; Reviewed; Region: PRK08215 264732002442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732002443 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264732002444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732002445 DNA binding residues [nucleotide binding] 264732002446 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 264732002447 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 264732002448 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 264732002449 HlyD family secretion protein; Region: HlyD_2; pfam12700 264732002450 putative membrane fusion protein; Region: TIGR02828 264732002451 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 264732002452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264732002453 catalytic residue [active] 264732002454 Protein of unknown function (DUF552); Region: DUF552; pfam04472 264732002455 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 264732002456 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 264732002457 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 264732002458 YGGT family; Region: YGGT; pfam02325 264732002459 DivIVA protein; Region: DivIVA; pfam05103 264732002460 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 264732002461 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 264732002462 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264732002463 active site 264732002464 HIGH motif; other site 264732002465 KMSKS motif; other site 264732002466 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 264732002467 tRNA binding surface [nucleotide binding]; other site 264732002468 anticodon binding site; other site 264732002469 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264732002470 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 264732002471 Propanediol utilisation protein PduL; Region: PduL; pfam06130 264732002472 Propanediol utilisation protein PduL; Region: PduL; pfam06130 264732002473 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 264732002474 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264732002475 dimer interface [polypeptide binding]; other site 264732002476 substrate binding site [chemical binding]; other site 264732002477 ATP binding site [chemical binding]; other site 264732002478 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 264732002479 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264732002480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732002481 RNA binding surface [nucleotide binding]; other site 264732002482 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264732002483 active site 264732002484 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 264732002485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732002486 S-adenosylmethionine binding site [chemical binding]; other site 264732002487 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 264732002488 Predicted permeases [General function prediction only]; Region: COG0679 264732002489 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; cl01319 264732002490 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 264732002491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264732002492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732002493 Walker A/P-loop; other site 264732002494 ATP binding site [chemical binding]; other site 264732002495 Q-loop/lid; other site 264732002496 ABC transporter signature motif; other site 264732002497 Walker B; other site 264732002498 D-loop; other site 264732002499 H-loop/switch region; other site 264732002500 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264732002501 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264732002502 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264732002503 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; pfam08735 264732002504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732002505 active site 264732002506 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264732002507 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264732002508 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264732002509 dihydroorotase; Validated; Region: pyrC; PRK09357 264732002510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264732002511 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 264732002512 active site 264732002513 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264732002514 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 264732002515 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264732002516 catalytic site [active] 264732002517 subunit interface [polypeptide binding]; other site 264732002518 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264732002519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264732002520 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264732002521 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 264732002522 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264732002523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264732002524 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264732002525 IMP binding site; other site 264732002526 dimer interface [polypeptide binding]; other site 264732002527 interdomain contacts; other site 264732002528 partial ornithine binding site; other site 264732002529 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 264732002530 active site 264732002531 dimer interface [polypeptide binding]; other site 264732002532 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 264732002533 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 264732002534 Domain of unknown function (DUF814); Region: DUF814; pfam05670 264732002535 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 264732002536 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 264732002537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264732002538 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 264732002539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732002540 motif II; other site 264732002541 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264732002542 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264732002543 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264732002544 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264732002545 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 264732002546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732002547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732002548 homodimer interface [polypeptide binding]; other site 264732002549 catalytic residue [active] 264732002550 hypothetical protein; Provisional; Region: PRK11820 264732002551 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264732002552 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264732002553 hypothetical protein; Provisional; Region: PRK04323 264732002554 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 264732002555 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 264732002556 Flavoprotein; Region: Flavoprotein; cl19190 264732002557 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 264732002558 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264732002559 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264732002560 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264732002561 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264732002562 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 264732002563 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264732002564 primosome assembly protein PriA; Validated; Region: PRK05580 264732002565 Helix-turn-helix domain; Region: HTH_20; pfam12840 264732002566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732002567 ATP binding site [chemical binding]; other site 264732002568 putative Mg++ binding site [ion binding]; other site 264732002569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732002570 nucleotide binding region [chemical binding]; other site 264732002571 ATP-binding site [chemical binding]; other site 264732002572 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264732002573 active site 264732002574 catalytic residues [active] 264732002575 metal binding site [ion binding]; metal-binding site 264732002576 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264732002577 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264732002578 putative active site [active] 264732002579 substrate binding site [chemical binding]; other site 264732002580 putative cosubstrate binding site; other site 264732002581 catalytic site [active] 264732002582 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264732002583 substrate binding site [chemical binding]; other site 264732002584 Protein of unknown function DUF116; Region: DUF116; pfam01976 264732002585 16S rRNA methyltransferase B; Provisional; Region: PRK14902 264732002586 NusB family; Region: NusB; pfam01029 264732002587 putative RNA binding site [nucleotide binding]; other site 264732002588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732002589 S-adenosylmethionine binding site [chemical binding]; other site 264732002590 putative transposase OrfB; Reviewed; Region: PHA02517 264732002591 HTH-like domain; Region: HTH_21; pfam13276 264732002592 Integrase core domain; Region: rve; pfam00665 264732002593 Integrase core domain; Region: rve_3; pfam13683 264732002594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732002595 Transposase; Region: HTH_Tnp_1; cl17663 264732002596 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 264732002597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732002598 ATP binding site [chemical binding]; other site 264732002599 Mg2+ binding site [ion binding]; other site 264732002600 G-X-G motif; other site 264732002601 Accessory gene regulator B; Region: AgrB; pfam04647 264732002602 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 264732002603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732002604 FeS/SAM binding site; other site 264732002605 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 264732002606 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264732002607 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264732002608 phosphopeptide binding site; other site 264732002609 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264732002610 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264732002611 phosphopeptide binding site; other site 264732002612 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264732002613 active site 264732002614 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 264732002615 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264732002616 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 264732002617 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264732002618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264732002619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264732002620 active site 264732002621 ATP binding site [chemical binding]; other site 264732002622 substrate binding site [chemical binding]; other site 264732002623 activation loop (A-loop); other site 264732002624 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264732002625 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264732002626 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264732002627 GTPase RsgA; Reviewed; Region: PRK00098 264732002628 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 264732002629 RNA binding site [nucleotide binding]; other site 264732002630 homodimer interface [polypeptide binding]; other site 264732002631 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264732002632 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264732002633 GTP/Mg2+ binding site [chemical binding]; other site 264732002634 G4 box; other site 264732002635 G5 box; other site 264732002636 G1 box; other site 264732002637 Switch I region; other site 264732002638 G2 box; other site 264732002639 G3 box; other site 264732002640 Switch II region; other site 264732002641 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264732002642 substrate binding site [chemical binding]; other site 264732002643 hexamer interface [polypeptide binding]; other site 264732002644 metal binding site [ion binding]; metal-binding site 264732002645 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 264732002646 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264732002647 catalytic motif [active] 264732002648 Zn binding site [ion binding]; other site 264732002649 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 264732002650 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264732002651 Lumazine binding domain; Region: Lum_binding; pfam00677 264732002652 Lumazine binding domain; Region: Lum_binding; pfam00677 264732002653 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 264732002654 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264732002655 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264732002656 dimerization interface [polypeptide binding]; other site 264732002657 active site 264732002658 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264732002659 homopentamer interface [polypeptide binding]; other site 264732002660 active site 264732002661 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 264732002662 active site 264732002663 metal binding site [ion binding]; metal-binding site 264732002664 homotetramer interface [polypeptide binding]; other site 264732002665 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 264732002666 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 264732002667 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 264732002668 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264732002669 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264732002670 generic binding surface II; other site 264732002671 ssDNA binding site; other site 264732002672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732002673 ATP binding site [chemical binding]; other site 264732002674 putative Mg++ binding site [ion binding]; other site 264732002675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732002676 nucleotide binding region [chemical binding]; other site 264732002677 ATP-binding site [chemical binding]; other site 264732002678 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 264732002679 germination protease; Provisional; Region: PRK12362 264732002680 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264732002681 catalytic residues [active] 264732002682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264732002683 ABC-ATPase subunit interface; other site 264732002684 dimer interface [polypeptide binding]; other site 264732002685 putative PBP binding regions; other site 264732002686 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264732002687 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264732002688 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 264732002689 Periplasmic solute binding protein family; Region: TroA; pfam01297 264732002690 intersubunit interface [polypeptide binding]; other site 264732002691 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264732002692 metal binding site 2 [ion binding]; metal-binding site 264732002693 putative DNA binding helix; other site 264732002694 metal binding site 1 [ion binding]; metal-binding site 264732002695 dimer interface [polypeptide binding]; other site 264732002696 structural Zn2+ binding site [ion binding]; other site 264732002697 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 264732002698 putative MPT binding site; other site 264732002699 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264732002700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264732002701 acyl-activating enzyme (AAE) consensus motif; other site 264732002702 AMP binding site [chemical binding]; other site 264732002703 active site 264732002704 CoA binding site [chemical binding]; other site 264732002705 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 264732002706 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 264732002707 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732002708 dimer interface [polypeptide binding]; other site 264732002709 PYR/PP interface [polypeptide binding]; other site 264732002710 TPP binding site [chemical binding]; other site 264732002711 substrate binding site [chemical binding]; other site 264732002712 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264732002713 TPP-binding site; other site 264732002714 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732002715 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264732002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732002717 S-adenosylmethionine binding site [chemical binding]; other site 264732002718 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264732002719 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 264732002720 Nucleoside recognition; Region: Gate; pfam07670 264732002721 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 264732002722 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 264732002723 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 264732002724 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 264732002725 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 264732002726 active site 2 [active] 264732002727 active site 1 [active] 264732002728 putative phosphate acyltransferase; Provisional; Region: PRK05331 264732002729 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264732002730 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264732002731 dimer interface [polypeptide binding]; other site 264732002732 active site 264732002733 CoA binding pocket [chemical binding]; other site 264732002734 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 264732002735 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264732002736 FMN binding site [chemical binding]; other site 264732002737 substrate binding site [chemical binding]; other site 264732002738 putative catalytic residue [active] 264732002739 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264732002740 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 264732002741 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264732002742 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264732002743 NAD(P) binding site [chemical binding]; other site 264732002744 homotetramer interface [polypeptide binding]; other site 264732002745 homodimer interface [polypeptide binding]; other site 264732002746 active site 264732002747 acyl carrier protein; Provisional; Region: acpP; PRK00982 264732002748 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 264732002749 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264732002750 dimer interface [polypeptide binding]; other site 264732002751 active site 264732002752 ribonuclease III; Reviewed; Region: rnc; PRK00102 264732002753 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264732002754 dimerization interface [polypeptide binding]; other site 264732002755 active site 264732002756 metal binding site [ion binding]; metal-binding site 264732002757 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264732002758 dsRNA binding site [nucleotide binding]; other site 264732002759 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 264732002760 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264732002761 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264732002762 Walker A/P-loop; other site 264732002763 ATP binding site [chemical binding]; other site 264732002764 Q-loop/lid; other site 264732002765 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 264732002766 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264732002767 Q-loop/lid; other site 264732002768 ABC transporter signature motif; other site 264732002769 Walker B; other site 264732002770 D-loop; other site 264732002771 H-loop/switch region; other site 264732002772 Putative zinc-finger; Region: zf-HC2; pfam13490 264732002773 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 264732002774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732002775 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264732002776 DNA binding residues [nucleotide binding] 264732002777 Putative zinc-finger; Region: zf-HC2; pfam13490 264732002778 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 264732002779 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264732002780 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264732002781 Walker A/P-loop; other site 264732002782 ATP binding site [chemical binding]; other site 264732002783 Q-loop/lid; other site 264732002784 ABC transporter signature motif; other site 264732002785 Walker B; other site 264732002786 D-loop; other site 264732002787 H-loop/switch region; other site 264732002788 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 264732002789 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264732002790 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 264732002791 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 264732002792 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 264732002793 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264732002794 active site 264732002795 putative substrate binding pocket [chemical binding]; other site 264732002796 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 264732002797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264732002798 active site 264732002799 catalytic tetrad [active] 264732002800 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732002801 putative DNA-binding protein; Validated; Region: PRK00118 264732002802 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264732002803 signal recognition particle protein; Provisional; Region: PRK10867 264732002804 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264732002805 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264732002806 P loop; other site 264732002807 GTP binding site [chemical binding]; other site 264732002808 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264732002809 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 264732002810 hypothetical protein; Provisional; Region: PRK00468 264732002811 G-X-X-G motif; other site 264732002812 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264732002813 RimM N-terminal domain; Region: RimM; pfam01782 264732002814 PRC-barrel domain; Region: PRC; pfam05239 264732002815 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264732002816 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264732002817 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264732002818 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264732002819 Catalytic site [active] 264732002820 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 264732002821 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 264732002822 GTP/Mg2+ binding site [chemical binding]; other site 264732002823 G4 box; other site 264732002824 G5 box; other site 264732002825 G1 box; other site 264732002826 Switch I region; other site 264732002827 G2 box; other site 264732002828 G3 box; other site 264732002829 Switch II region; other site 264732002830 Sensor protein DegS; Region: DegS; pfam05384 264732002831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264732002832 Histidine kinase; Region: HisKA_3; pfam07730 264732002833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732002834 ATP binding site [chemical binding]; other site 264732002835 Mg2+ binding site [ion binding]; other site 264732002836 G-X-G motif; other site 264732002837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264732002838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732002839 active site 264732002840 phosphorylation site [posttranslational modification] 264732002841 intermolecular recognition site; other site 264732002842 dimerization interface [polypeptide binding]; other site 264732002843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264732002844 DNA binding residues [nucleotide binding] 264732002845 dimerization interface [polypeptide binding]; other site 264732002846 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264732002847 RNA/DNA hybrid binding site [nucleotide binding]; other site 264732002848 active site 264732002849 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 264732002850 NADH dehydrogenase subunit B; Validated; Region: PRK06411 264732002851 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 264732002852 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 264732002853 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 264732002854 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264732002855 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 264732002856 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732002857 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 264732002858 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 264732002859 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264732002860 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264732002861 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732002862 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 264732002863 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264732002864 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732002865 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264732002866 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732002867 hypothetical protein; Reviewed; Region: PRK12497 264732002868 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 264732002869 active site 264732002870 Zn binding site [ion binding]; other site 264732002871 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264732002872 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264732002873 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264732002874 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264732002875 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264732002876 active site 264732002877 metal binding site [ion binding]; metal-binding site 264732002878 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 264732002879 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264732002880 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 264732002881 putative active site [active] 264732002882 putative metal binding site [ion binding]; other site 264732002883 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 264732002884 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264732002885 catalytic triad [active] 264732002886 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264732002887 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 264732002888 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264732002889 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264732002890 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732002891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732002892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732002893 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264732002894 putative substrate translocation pore; other site 264732002895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732002896 H+ Antiporter protein; Region: 2A0121; TIGR00900 264732002897 putative substrate translocation pore; other site 264732002898 Uncharacterized conserved protein [Function unknown]; Region: COG3603 264732002899 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like; cd04868 264732002900 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 264732002901 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732002902 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 264732002903 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 264732002904 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 264732002905 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 264732002906 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 264732002907 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 264732002908 Protein of unknown function (DUF441); Region: DUF441; pfam04284 264732002909 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264732002910 Spore germination protein; Region: Spore_permease; cl17796 264732002911 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 264732002912 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 264732002913 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 264732002914 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 264732002915 dimanganese center [ion binding]; other site 264732002916 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 264732002917 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264732002918 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264732002919 putative active site [active] 264732002920 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 264732002921 Transcription factor AP-2; Region: TF_AP-2; pfam03299 264732002922 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 264732002923 PemK-like protein; Region: PemK; cl00995 264732002924 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264732002925 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264732002926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732002927 Walker A motif; other site 264732002928 ATP binding site [chemical binding]; other site 264732002929 Walker B motif; other site 264732002930 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264732002931 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl19624 264732002932 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 264732002933 dimer interface [polypeptide binding]; other site 264732002934 active site 264732002935 metal binding site [ion binding]; metal-binding site 264732002936 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 264732002937 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 264732002938 DNA topoisomerase I; Validated; Region: PRK05582 264732002939 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264732002940 active site 264732002941 interdomain interaction site; other site 264732002942 putative metal-binding site [ion binding]; other site 264732002943 nucleotide binding site [chemical binding]; other site 264732002944 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264732002945 domain I; other site 264732002946 DNA binding groove [nucleotide binding] 264732002947 phosphate binding site [ion binding]; other site 264732002948 domain II; other site 264732002949 domain III; other site 264732002950 nucleotide binding site [chemical binding]; other site 264732002951 catalytic site [active] 264732002952 domain IV; other site 264732002953 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264732002954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264732002955 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 264732002956 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 264732002957 Glucose inhibited division protein A; Region: GIDA; pfam01134 264732002958 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264732002959 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 264732002960 active site 264732002961 DNA binding site [nucleotide binding] 264732002962 Int/Topo IB signature motif; other site 264732002963 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 264732002964 active site 264732002965 HslU subunit interaction site [polypeptide binding]; other site 264732002966 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 264732002967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732002968 Walker A motif; other site 264732002969 ATP binding site [chemical binding]; other site 264732002970 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 264732002971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264732002972 transcriptional repressor CodY; Validated; Region: PRK04158 264732002973 CodY GAF-like domain; Region: CodY; pfam06018 264732002974 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 264732002975 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264732002976 rRNA interaction site [nucleotide binding]; other site 264732002977 S8 interaction site; other site 264732002978 putative laminin-1 binding site; other site 264732002979 elongation factor Ts; Reviewed; Region: tsf; PRK12332 264732002980 UBA/TS-N domain; Region: UBA; pfam00627 264732002981 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 264732002982 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264732002983 putative nucleotide binding site [chemical binding]; other site 264732002984 uridine monophosphate binding site [chemical binding]; other site 264732002985 homohexameric interface [polypeptide binding]; other site 264732002986 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264732002987 hinge region; other site 264732002988 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732002989 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732002990 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 264732002991 active site 264732002992 dimer interface [polypeptide binding]; other site 264732002993 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 264732002994 Domain of unknown function DUF20; Region: UPF0118; cl00465 264732002995 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264732002996 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264732002997 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264732002998 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264732002999 RIP metalloprotease RseP; Region: TIGR00054 264732003000 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264732003001 active site 264732003002 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264732003003 protein binding site [polypeptide binding]; other site 264732003004 putative substrate binding region [chemical binding]; other site 264732003005 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 264732003006 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 264732003007 prolyl-tRNA synthetase; Provisional; Region: PRK09194 264732003008 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 264732003009 dimer interface [polypeptide binding]; other site 264732003010 motif 1; other site 264732003011 active site 264732003012 motif 2; other site 264732003013 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 264732003014 putative deacylase active site [active] 264732003015 motif 3; other site 264732003016 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 264732003017 anticodon binding site; other site 264732003018 DNA polymerase III PolC; Validated; Region: polC; PRK00448 264732003019 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 264732003020 generic binding surface II; other site 264732003021 generic binding surface I; other site 264732003022 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 264732003023 active site 264732003024 putative PHP Thumb interface [polypeptide binding]; other site 264732003025 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264732003026 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 264732003027 Sm and related proteins; Region: Sm_like; cl00259 264732003028 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 264732003029 putative oligomer interface [polypeptide binding]; other site 264732003030 putative RNA binding site [nucleotide binding]; other site 264732003031 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 264732003032 NusA N-terminal domain; Region: NusA_N; pfam08529 264732003033 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264732003034 RNA binding site [nucleotide binding]; other site 264732003035 homodimer interface [polypeptide binding]; other site 264732003036 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264732003037 G-X-X-G motif; other site 264732003038 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264732003039 G-X-X-G motif; other site 264732003040 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 264732003041 putative RNA binding cleft [nucleotide binding]; other site 264732003042 Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358 264732003043 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264732003044 translation initiation factor IF-2; Validated; Region: infB; PRK05306 264732003045 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264732003046 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264732003047 G1 box; other site 264732003048 putative GEF interaction site [polypeptide binding]; other site 264732003049 GTP/Mg2+ binding site [chemical binding]; other site 264732003050 Switch I region; other site 264732003051 G2 box; other site 264732003052 G3 box; other site 264732003053 Switch II region; other site 264732003054 G4 box; other site 264732003055 G5 box; other site 264732003056 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264732003057 Translation-initiation factor 2; Region: IF-2; pfam11987 264732003058 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264732003059 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 264732003060 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 264732003061 DHH family; Region: DHH; pfam01368 264732003062 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 264732003063 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264732003064 RNA binding site [nucleotide binding]; other site 264732003065 active site 264732003066 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264732003067 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264732003068 active site 264732003069 Riboflavin kinase; Region: Flavokinase; smart00904 264732003070 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264732003071 16S/18S rRNA binding site [nucleotide binding]; other site 264732003072 S13e-L30e interaction site [polypeptide binding]; other site 264732003073 25S rRNA binding site [nucleotide binding]; other site 264732003074 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264732003075 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264732003076 RNase E interface [polypeptide binding]; other site 264732003077 trimer interface [polypeptide binding]; other site 264732003078 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264732003079 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264732003080 RNase E interface [polypeptide binding]; other site 264732003081 trimer interface [polypeptide binding]; other site 264732003082 active site 264732003083 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264732003084 putative nucleic acid binding region [nucleotide binding]; other site 264732003085 G-X-X-G motif; other site 264732003086 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264732003087 RNA binding site [nucleotide binding]; other site 264732003088 domain interface; other site 264732003089 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 264732003090 NodB motif; other site 264732003091 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264732003092 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 264732003093 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 264732003094 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264732003095 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264732003096 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264732003097 dUTPase; Region: dUTPase_2; pfam08761 264732003098 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 264732003099 active site 264732003100 homodimer interface [polypeptide binding]; other site 264732003101 metal binding site [ion binding]; metal-binding site 264732003102 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 264732003103 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264732003104 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264732003105 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264732003106 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 264732003107 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 264732003108 NAD(P) binding pocket [chemical binding]; other site 264732003109 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 264732003110 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 264732003111 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 264732003112 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 264732003113 aspartate kinase I; Reviewed; Region: PRK08210 264732003114 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 264732003115 nucleotide binding site [chemical binding]; other site 264732003116 substrate binding site [chemical binding]; other site 264732003117 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264732003118 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264732003119 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264732003120 dimer interface [polypeptide binding]; other site 264732003121 active site 264732003122 catalytic residue [active] 264732003123 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 264732003124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264732003125 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 264732003126 YlzJ-like protein; Region: YlzJ; pfam14035 264732003127 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 264732003128 active site 264732003129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732003130 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 264732003131 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264732003132 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264732003133 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 264732003134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732003135 non-specific DNA binding site [nucleotide binding]; other site 264732003136 salt bridge; other site 264732003137 sequence-specific DNA binding site [nucleotide binding]; other site 264732003138 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 264732003139 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 264732003140 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 264732003141 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264732003142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003143 FeS/SAM binding site; other site 264732003144 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264732003145 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264732003146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732003147 Walker A motif; other site 264732003148 ATP binding site [chemical binding]; other site 264732003149 Walker B motif; other site 264732003150 arginine finger; other site 264732003151 Peptidase family M41; Region: Peptidase_M41; pfam01434 264732003152 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 264732003153 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264732003154 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264732003155 recombinase A; Provisional; Region: recA; PRK09354 264732003156 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264732003157 hexamer interface [polypeptide binding]; other site 264732003158 Walker A motif; other site 264732003159 ATP binding site [chemical binding]; other site 264732003160 Walker B motif; other site 264732003161 RecX family; Region: RecX; pfam02631 264732003162 phosphodiesterase; Provisional; Region: PRK12704 264732003163 KH domain; Region: KH_1; pfam00013 264732003164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732003165 Zn2+ binding site [ion binding]; other site 264732003166 Mg2+ binding site [ion binding]; other site 264732003167 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 264732003168 putative active site [active] 264732003169 metal binding site [ion binding]; metal-binding site 264732003170 homodimer binding site [polypeptide binding]; other site 264732003171 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 264732003172 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264732003173 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264732003174 active site 264732003175 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 264732003176 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732003177 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 264732003178 homotrimer interface [polypeptide binding]; other site 264732003179 Walker A motif; other site 264732003180 GTP binding site [chemical binding]; other site 264732003181 Walker B motif; other site 264732003182 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 264732003183 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 264732003184 active site 264732003185 putative homodimer interface [polypeptide binding]; other site 264732003186 SAM binding site [chemical binding]; other site 264732003187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732003188 S-adenosylmethionine binding site [chemical binding]; other site 264732003189 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 264732003190 active site 264732003191 SAM binding site [chemical binding]; other site 264732003192 homodimer interface [polypeptide binding]; other site 264732003193 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 264732003194 active site 264732003195 SAM binding site [chemical binding]; other site 264732003196 homodimer interface [polypeptide binding]; other site 264732003197 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 264732003198 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 264732003199 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 264732003200 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 264732003201 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 264732003202 active site 264732003203 SAM binding site [chemical binding]; other site 264732003204 homodimer interface [polypeptide binding]; other site 264732003205 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 264732003206 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 264732003207 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 264732003208 putative active site [active] 264732003209 Precorrin-8X methylmutase; Region: CbiC; pfam02570 264732003210 cobyric acid synthase; Provisional; Region: PRK00784 264732003211 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732003212 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264732003213 catalytic triad [active] 264732003214 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 264732003215 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 264732003216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732003217 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 264732003218 catalytic triad [active] 264732003219 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264732003220 active site pocket [active] 264732003221 putative dimer interface [polypeptide binding]; other site 264732003222 cobalamin synthase; Reviewed; Region: cobS; PRK00235 264732003223 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 264732003224 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 264732003225 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 264732003226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732003227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732003228 homodimer interface [polypeptide binding]; other site 264732003229 catalytic residue [active] 264732003230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264732003231 catalytic core [active] 264732003232 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264732003233 EamA-like transporter family; Region: EamA; pfam00892 264732003234 EamA-like transporter family; Region: EamA; pfam00892 264732003235 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264732003236 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264732003237 active site 264732003238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 264732003239 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 264732003240 Domain of unknown function (DUF362); Region: DUF362; cl19822 264732003241 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732003242 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264732003243 trimer interface [polypeptide binding]; other site 264732003244 putative Zn binding site [ion binding]; other site 264732003245 Bifunctional nuclease; Region: DNase-RNase; pfam02577 264732003246 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 264732003247 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264732003248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003249 FeS/SAM binding site; other site 264732003250 TRAM domain; Region: TRAM; pfam01938 264732003251 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264732003252 MutS domain I; Region: MutS_I; pfam01624 264732003253 MutS domain II; Region: MutS_II; pfam05188 264732003254 MutS domain III; Region: MutS_III; pfam05192 264732003255 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 264732003256 Walker A/P-loop; other site 264732003257 ATP binding site [chemical binding]; other site 264732003258 Q-loop/lid; other site 264732003259 ABC transporter signature motif; other site 264732003260 Walker B; other site 264732003261 D-loop; other site 264732003262 H-loop/switch region; other site 264732003263 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264732003264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732003265 ATP binding site [chemical binding]; other site 264732003266 Mg2+ binding site [ion binding]; other site 264732003267 G-X-G motif; other site 264732003268 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 264732003269 ATP binding site [chemical binding]; other site 264732003270 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 264732003271 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264732003272 bacterial Hfq-like; Region: Hfq; cd01716 264732003273 hexamer interface [polypeptide binding]; other site 264732003274 Sm1 motif; other site 264732003275 RNA binding site [nucleotide binding]; other site 264732003276 Sm2 motif; other site 264732003277 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 264732003278 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 264732003279 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732003280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732003281 Walker A motif; other site 264732003282 ATP binding site [chemical binding]; other site 264732003283 Walker B motif; other site 264732003284 arginine finger; other site 264732003285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 264732003286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732003287 catalytic residue [active] 264732003288 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264732003289 LexA repressor; Validated; Region: PRK00215 264732003290 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264732003291 Catalytic site [active] 264732003292 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264732003293 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264732003294 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 264732003295 dimer interface [polypeptide binding]; other site 264732003296 active site 264732003297 citrylCoA binding site [chemical binding]; other site 264732003298 oxalacetate/citrate binding site [chemical binding]; other site 264732003299 coenzyme A binding site [chemical binding]; other site 264732003300 catalytic triad [active] 264732003301 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 264732003302 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 264732003303 AP (apurinic/apyrimidinic) site pocket; other site 264732003304 DNA interaction; other site 264732003305 Metal-binding active site; metal-binding site 264732003306 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264732003307 EamA-like transporter family; Region: EamA; pfam00892 264732003308 EamA-like transporter family; Region: EamA; pfam00892 264732003309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264732003310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264732003311 substrate binding pocket [chemical binding]; other site 264732003312 membrane-bound complex binding site; other site 264732003313 hinge residues; other site 264732003314 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 264732003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732003316 dimer interface [polypeptide binding]; other site 264732003317 conserved gate region; other site 264732003318 putative PBP binding loops; other site 264732003319 ABC-ATPase subunit interface; other site 264732003320 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264732003321 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264732003322 Walker A/P-loop; other site 264732003323 ATP binding site [chemical binding]; other site 264732003324 Q-loop/lid; other site 264732003325 ABC transporter signature motif; other site 264732003326 Walker B; other site 264732003327 D-loop; other site 264732003328 H-loop/switch region; other site 264732003329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264732003330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732003331 dimerization interface [polypeptide binding]; other site 264732003332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264732003333 dimer interface [polypeptide binding]; other site 264732003334 phosphorylation site [posttranslational modification] 264732003335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732003336 ATP binding site [chemical binding]; other site 264732003337 Mg2+ binding site [ion binding]; other site 264732003338 G-X-G motif; other site 264732003339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732003341 active site 264732003342 phosphorylation site [posttranslational modification] 264732003343 intermolecular recognition site; other site 264732003344 dimerization interface [polypeptide binding]; other site 264732003345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264732003346 DNA binding site [nucleotide binding] 264732003347 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264732003348 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264732003349 active site 264732003350 HIGH motif; other site 264732003351 KMSKS motif; other site 264732003352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732003353 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 264732003354 putative ADP-binding pocket [chemical binding]; other site 264732003355 FOG: CBS domain [General function prediction only]; Region: COG0517 264732003356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 264732003357 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264732003358 FOG: CBS domain [General function prediction only]; Region: COG0517 264732003359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 264732003360 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264732003361 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 264732003362 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 264732003363 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 264732003364 active site 264732003365 dimer interface [polypeptide binding]; other site 264732003366 effector binding site; other site 264732003367 TSCPD domain; Region: TSCPD; pfam12637 264732003368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264732003369 dimer interface [polypeptide binding]; other site 264732003370 phosphorylation site [posttranslational modification] 264732003371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732003372 ATP binding site [chemical binding]; other site 264732003373 Mg2+ binding site [ion binding]; other site 264732003374 G-X-G motif; other site 264732003375 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 264732003376 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 264732003377 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264732003378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264732003379 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264732003380 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264732003381 active site 264732003382 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 264732003383 elongation factor G; Reviewed; Region: PRK12740 264732003384 G1 box; other site 264732003385 putative GEF interaction site [polypeptide binding]; other site 264732003386 GTP/Mg2+ binding site [chemical binding]; other site 264732003387 Switch I region; other site 264732003388 G2 box; other site 264732003389 G3 box; other site 264732003390 Switch II region; other site 264732003391 G4 box; other site 264732003392 G5 box; other site 264732003393 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264732003394 Elongation Factor G, domain II; Region: EFG_II; pfam14492 264732003395 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264732003396 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264732003397 stage V sporulation protein B; Region: spore_V_B; TIGR02900 264732003398 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 264732003399 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 264732003400 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 264732003401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264732003402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732003403 binding surface 264732003404 TPR motif; other site 264732003405 TPR repeat; Region: TPR_11; pfam13414 264732003406 TPR repeat; Region: TPR_11; pfam13414 264732003407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732003408 binding surface 264732003409 TPR motif; other site 264732003410 TPR repeat; Region: TPR_11; pfam13414 264732003411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732003412 binding surface 264732003413 TPR motif; other site 264732003414 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264732003415 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264732003416 metal binding site 2 [ion binding]; metal-binding site 264732003417 putative DNA binding helix; other site 264732003418 metal binding site 1 [ion binding]; metal-binding site 264732003419 dimer interface [polypeptide binding]; other site 264732003420 structural Zn2+ binding site [ion binding]; other site 264732003421 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 264732003422 Svf1-like; Region: Svf1; pfam08622 264732003423 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 264732003424 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264732003425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 264732003426 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 264732003427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 264732003428 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 264732003429 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 264732003430 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264732003431 active site 264732003432 catalytic site [active] 264732003433 substrate binding site [chemical binding]; other site 264732003434 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 264732003435 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264732003436 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264732003437 carboxyltransferase (CT) interaction site; other site 264732003438 biotinylation site [posttranslational modification]; other site 264732003439 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 264732003440 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264732003441 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 264732003442 thiamine monophosphate kinase; Provisional; Region: PRK05731 264732003443 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264732003444 ATP binding site [chemical binding]; other site 264732003445 dimerization interface [polypeptide binding]; other site 264732003446 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 264732003447 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264732003448 Interdomain contacts; other site 264732003449 Cytokine receptor motif; other site 264732003450 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264732003451 active site 264732003452 metal binding site [ion binding]; metal-binding site 264732003453 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732003454 HlyD family secretion protein; Region: HlyD_2; pfam12700 264732003455 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 264732003456 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264732003457 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264732003458 Walker A/P-loop; other site 264732003459 ATP binding site [chemical binding]; other site 264732003460 Q-loop/lid; other site 264732003461 ABC transporter signature motif; other site 264732003462 Walker B; other site 264732003463 D-loop; other site 264732003464 H-loop/switch region; other site 264732003465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732003466 DNA-binding site [nucleotide binding]; DNA binding site 264732003467 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 264732003468 putative active site [active] 264732003469 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264732003470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003471 FeS/SAM binding site; other site 264732003472 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 264732003473 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732003474 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732003475 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 264732003476 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 264732003477 FAD binding pocket [chemical binding]; other site 264732003478 FAD binding motif [chemical binding]; other site 264732003479 phosphate binding motif [ion binding]; other site 264732003480 beta-alpha-beta structure motif; other site 264732003481 NAD binding pocket [chemical binding]; other site 264732003482 Iron coordination center [ion binding]; other site 264732003483 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 264732003484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732003485 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 264732003486 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264732003487 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 264732003488 Walker A/P-loop; other site 264732003489 ATP binding site [chemical binding]; other site 264732003490 Q-loop/lid; other site 264732003491 ABC transporter signature motif; other site 264732003492 Walker B; other site 264732003493 D-loop; other site 264732003494 H-loop/switch region; other site 264732003495 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264732003496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264732003497 Walker A/P-loop; other site 264732003498 ATP binding site [chemical binding]; other site 264732003499 Q-loop/lid; other site 264732003500 ABC transporter signature motif; other site 264732003501 Walker B; other site 264732003502 D-loop; other site 264732003503 H-loop/switch region; other site 264732003504 Predicted transcriptional regulators [Transcription]; Region: COG1725 264732003505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732003506 DNA-binding site [nucleotide binding]; DNA binding site 264732003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264732003508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732003509 S-adenosylmethionine binding site [chemical binding]; other site 264732003510 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264732003511 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264732003512 Bacterial transcriptional regulator; Region: IclR; pfam01614 264732003513 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264732003514 active site 264732003515 FMN binding site [chemical binding]; other site 264732003516 substrate binding site [chemical binding]; other site 264732003517 3Fe-4S cluster binding site [ion binding]; other site 264732003518 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264732003519 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264732003520 Bacterial transcriptional regulator; Region: IclR; pfam01614 264732003521 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 264732003522 Propanediol utilisation protein PduL; Region: PduL; pfam06130 264732003523 Propanediol utilisation protein PduL; Region: PduL; pfam06130 264732003524 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264732003525 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264732003526 G1 box; other site 264732003527 GTP/Mg2+ binding site [chemical binding]; other site 264732003528 Switch I region; other site 264732003529 G2 box; other site 264732003530 G3 box; other site 264732003531 Switch II region; other site 264732003532 G4 box; other site 264732003533 G5 box; other site 264732003534 Nucleoside recognition; Region: Gate; pfam07670 264732003535 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264732003536 Nucleoside recognition; Region: Gate; pfam07670 264732003537 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 264732003538 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 264732003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732003540 Walker A motif; other site 264732003541 ATP binding site [chemical binding]; other site 264732003542 Walker B motif; other site 264732003543 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 264732003544 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 264732003545 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 264732003546 AAA domain; Region: AAA_33; pfam13671 264732003547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 264732003548 G1 box; other site 264732003549 GTP/Mg2+ binding site [chemical binding]; other site 264732003550 G2 box; other site 264732003551 Switch I region; other site 264732003552 G3 box; other site 264732003553 Switch II region; other site 264732003554 G4 box; other site 264732003555 Asp23 family; Region: Asp23; pfam03780 264732003556 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 264732003557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264732003558 Beta-Casp domain; Region: Beta-Casp; smart01027 264732003559 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 264732003560 aspartate aminotransferase; Provisional; Region: PRK05764 264732003561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732003562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732003563 homodimer interface [polypeptide binding]; other site 264732003564 catalytic residue [active] 264732003565 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264732003566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732003567 septum formation inhibitor; Provisional; Region: minC; PRK00030 264732003568 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264732003569 FAD binding site [chemical binding]; other site 264732003570 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 264732003571 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 264732003572 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732003573 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732003574 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 264732003575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732003576 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 264732003577 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732003578 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732003579 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732003580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264732003581 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732003582 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 264732003583 Cysteine-rich domain; Region: CCG; pfam02754 264732003584 Cysteine-rich domain; Region: CCG; pfam02754 264732003585 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732003586 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264732003587 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 264732003588 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264732003589 substrate binding pocket [chemical binding]; other site 264732003590 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 264732003591 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 264732003592 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 264732003593 P-loop; other site 264732003594 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 264732003595 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732003596 catalytic loop [active] 264732003597 iron binding site [ion binding]; other site 264732003598 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 264732003599 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 264732003600 Putative Fe-S cluster; Region: FeS; pfam04060 264732003601 CO dehydrogenase/acetyl-CoA synthase delta subunit; Region: CdhD; pfam03599 264732003602 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 264732003603 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 264732003604 CODH interaction site; other site 264732003605 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 264732003606 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 264732003607 ACS interaction site; other site 264732003608 CODH interaction site; other site 264732003609 cubane metal cluster (B-cluster) [ion binding]; other site 264732003610 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 264732003611 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 264732003612 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 264732003613 P-loop; other site 264732003614 Sensory domain found in PocR; Region: PocR; pfam10114 264732003615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264732003616 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264732003617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264732003618 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732003619 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 264732003620 B12 binding site [chemical binding]; other site 264732003621 cobalt ligand [ion binding]; other site 264732003622 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 264732003623 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264732003624 substrate binding pocket [chemical binding]; other site 264732003625 dimer interface [polypeptide binding]; other site 264732003626 inhibitor binding site; inhibition site 264732003627 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732003628 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 264732003629 B12 binding site [chemical binding]; other site 264732003630 cobalt ligand [ion binding]; other site 264732003631 Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176 264732003632 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 264732003633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732003634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264732003635 putative substrate translocation pore; other site 264732003636 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 264732003637 putative FMN binding site [chemical binding]; other site 264732003638 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 264732003639 DNA methylase; Region: N6_N4_Mtase; pfam01555 264732003640 Yqey-like protein; Region: YqeY; pfam09424 264732003641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264732003642 EamA-like transporter family; Region: EamA; pfam00892 264732003643 EamA-like transporter family; Region: EamA; pfam00892 264732003644 Acylphosphatase; Region: Acylphosphatase; pfam00708 264732003645 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 264732003646 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 264732003647 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732003648 Walker A/P-loop; other site 264732003649 ATP binding site [chemical binding]; other site 264732003650 Q-loop/lid; other site 264732003651 ABC transporter signature motif; other site 264732003652 Walker B; other site 264732003653 D-loop; other site 264732003654 H-loop/switch region; other site 264732003655 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 264732003656 cobalt transport protein CbiN; Provisional; Region: PRK02898 264732003657 cobalt transport protein CbiM; Validated; Region: PRK08319 264732003658 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 264732003659 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 264732003660 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264732003661 active site 264732003662 putative substrate binding pocket [chemical binding]; other site 264732003663 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264732003664 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264732003665 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264732003666 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264732003667 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732003668 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732003669 DNA polymerase IV; Reviewed; Region: PRK03103 264732003670 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264732003671 active site 264732003672 DNA binding site [nucleotide binding] 264732003673 Peptidase family M48; Region: Peptidase_M48; pfam01435 264732003674 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264732003675 QueT transporter; Region: QueT; pfam06177 264732003676 6-phosphofructokinase; Provisional; Region: PRK14072 264732003677 active site 264732003678 ADP/pyrophosphate binding site [chemical binding]; other site 264732003679 dimerization interface [polypeptide binding]; other site 264732003680 allosteric effector site; other site 264732003681 fructose-1,6-bisphosphate binding site; other site 264732003682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003683 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264732003684 FeS/SAM binding site; other site 264732003685 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264732003686 Protein of unknown function (DUF512); Region: DUF512; pfam04459 264732003687 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 264732003688 Phosphate transporter family; Region: PHO4; pfam01384 264732003689 Cell division protein FtsA; Region: FtsA; smart00842 264732003690 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 264732003691 Cell division protein FtsA; Region: FtsA; pfam14450 264732003692 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264732003693 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 264732003694 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 264732003695 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264732003696 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 264732003697 putative [4Fe-4S] binding site [ion binding]; other site 264732003698 putative molybdopterin cofactor binding site [chemical binding]; other site 264732003699 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 264732003700 putative molybdopterin cofactor binding site; other site 264732003701 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264732003702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264732003703 inhibitor-cofactor binding pocket; inhibition site 264732003704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732003705 catalytic residue [active] 264732003706 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 264732003707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003708 FeS/SAM binding site; other site 264732003709 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264732003710 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 264732003711 dimer interface [polypeptide binding]; other site 264732003712 active site 264732003713 Schiff base residues; other site 264732003714 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 264732003715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732003716 FeS/SAM binding site; other site 264732003717 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264732003718 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 264732003719 active site 264732003720 SAM binding site [chemical binding]; other site 264732003721 homodimer interface [polypeptide binding]; other site 264732003722 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264732003723 active site 264732003724 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 264732003725 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 264732003726 domain interfaces; other site 264732003727 active site 264732003728 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 264732003729 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 264732003730 tRNA; other site 264732003731 putative tRNA binding site [nucleotide binding]; other site 264732003732 putative NADP binding site [chemical binding]; other site 264732003733 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 264732003734 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 264732003735 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 264732003736 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 264732003737 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264732003738 substrate binding pocket [chemical binding]; other site 264732003739 chain length determination region; other site 264732003740 substrate-Mg2+ binding site; other site 264732003741 catalytic residues [active] 264732003742 aspartate-rich region 1; other site 264732003743 active site lid residues [active] 264732003744 aspartate-rich region 2; other site 264732003745 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 264732003746 O-Antigen ligase; Region: Wzy_C; pfam04932 264732003747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732003748 binding surface 264732003749 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264732003750 TPR motif; other site 264732003751 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264732003752 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 264732003753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 264732003754 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 264732003755 homodimer interface [polypeptide binding]; other site 264732003756 Chs6 interaction interface [polypeptide binding]; other site 264732003757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264732003758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732003759 putative substrate translocation pore; other site 264732003760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264732003761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264732003762 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264732003763 NAD(P) binding site [chemical binding]; other site 264732003764 homotetramer interface [polypeptide binding]; other site 264732003765 homodimer interface [polypeptide binding]; other site 264732003766 active site 264732003767 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 264732003768 Coenzyme A transferase; Region: CoA_trans; smart00882 264732003769 Coenzyme A transferase; Region: CoA_trans; cl17247 264732003770 putative acyltransferase; Provisional; Region: PRK05790 264732003771 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264732003772 dimer interface [polypeptide binding]; other site 264732003773 active site 264732003774 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264732003775 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 264732003776 acyl-activating enzyme (AAE) consensus motif; other site 264732003777 putative AMP binding site [chemical binding]; other site 264732003778 putative active site [active] 264732003779 putative CoA binding site [chemical binding]; other site 264732003780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264732003781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264732003782 DNA binding site [nucleotide binding] 264732003783 domain linker motif; other site 264732003784 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264732003785 dimerization interface [polypeptide binding]; other site 264732003786 ligand binding site [chemical binding]; other site 264732003787 Domain of unknown function DUF302; Region: DUF302; pfam03625 264732003788 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 264732003789 SxDxEG motif; other site 264732003790 active site 264732003791 metal binding site [ion binding]; metal-binding site 264732003792 homopentamer interface [polypeptide binding]; other site 264732003793 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264732003794 metal-binding site [ion binding] 264732003795 hypothetical protein; Provisional; Region: PRK05802 264732003796 Protein interacting with poly(A)-binding protein [RNA processing and modification]; Region: PBP1; COG5180 264732003797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732003798 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264732003799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732003800 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264732003801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732003802 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264732003803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264732003804 active site 264732003805 metal binding site [ion binding]; metal-binding site 264732003806 S-layer homology domain; Region: SLH; pfam00395 264732003807 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 264732003808 Aspartase; Region: Aspartase; cd01357 264732003809 active sites [active] 264732003810 tetramer interface [polypeptide binding]; other site 264732003811 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 264732003812 active site 264732003813 dimer interfaces [polypeptide binding]; other site 264732003814 catalytic residues [active] 264732003815 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 264732003816 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 264732003817 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 264732003818 G1 box; other site 264732003819 GTP/Mg2+ binding site [chemical binding]; other site 264732003820 Switch I region; other site 264732003821 G2 box; other site 264732003822 Switch II region; other site 264732003823 G3 box; other site 264732003824 G4 box; other site 264732003825 G5 box; other site 264732003826 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 264732003827 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 264732003828 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264732003829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732003830 S-adenosylmethionine binding site [chemical binding]; other site 264732003831 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 264732003832 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 264732003833 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264732003834 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 264732003835 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 264732003836 Rubredoxin [Energy production and conversion]; Region: COG1773 264732003837 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264732003838 iron binding site [ion binding]; other site 264732003839 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 264732003840 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 264732003841 non-heme iron binding site [ion binding]; other site 264732003842 dimer interface [polypeptide binding]; other site 264732003843 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 264732003844 non-heme iron binding site [ion binding]; other site 264732003845 dimer interface [polypeptide binding]; other site 264732003846 Rubrerythrin [Energy production and conversion]; Region: COG1592 264732003847 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 264732003848 binuclear metal center [ion binding]; other site 264732003849 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 264732003850 iron binding site [ion binding]; other site 264732003851 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 264732003852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264732003853 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264732003854 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 264732003855 Rubredoxin [Energy production and conversion]; Region: COG1773 264732003856 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264732003857 iron binding site [ion binding]; other site 264732003858 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 264732003859 putative subunit interface; other site 264732003860 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264732003861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732003862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732003863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732003864 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732003865 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732003866 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732003867 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264732003868 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264732003869 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 264732003870 active site 264732003871 FMN binding site [chemical binding]; other site 264732003872 substrate binding site [chemical binding]; other site 264732003873 3Fe-4S cluster binding site [ion binding]; other site 264732003874 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 264732003875 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 264732003876 putative active site [active] 264732003877 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264732003878 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264732003879 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264732003880 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 264732003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732003882 active site 264732003883 phosphorylation site [posttranslational modification] 264732003884 intermolecular recognition site; other site 264732003885 dimerization interface [polypeptide binding]; other site 264732003886 ANTAR domain; Region: ANTAR; pfam03861 264732003887 hypothetical protein; Provisional; Region: PRK06851 264732003888 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264732003889 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264732003890 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264732003891 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 264732003892 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 264732003893 active site 264732003894 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 264732003895 dimer interface [polypeptide binding]; other site 264732003896 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 264732003897 Ligand Binding Site [chemical binding]; other site 264732003898 Molecular Tunnel; other site 264732003899 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264732003900 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264732003901 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264732003902 active site 264732003903 putative substrate binding pocket [chemical binding]; other site 264732003904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732003905 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732003906 aspartate kinase; Reviewed; Region: PRK06635 264732003907 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264732003908 putative nucleotide binding site [chemical binding]; other site 264732003909 putative catalytic residues [active] 264732003910 putative Mg ion binding site [ion binding]; other site 264732003911 putative aspartate binding site [chemical binding]; other site 264732003912 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 264732003913 putative allosteric regulatory site; other site 264732003914 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 264732003915 homoserine kinase; Provisional; Region: PRK01212 264732003916 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264732003917 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 264732003918 homodimer interface [polypeptide binding]; other site 264732003919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732003920 catalytic residue [active] 264732003921 homoserine dehydrogenase; Provisional; Region: PRK06349 264732003922 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 264732003923 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264732003924 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 264732003925 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 264732003926 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 264732003927 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264732003928 homodimer interface [polypeptide binding]; other site 264732003929 substrate-cofactor binding pocket; other site 264732003930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732003931 catalytic residue [active] 264732003932 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264732003933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732003934 DNA-binding site [nucleotide binding]; DNA binding site 264732003935 FCD domain; Region: FCD; pfam07729 264732003936 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264732003937 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 264732003938 B12 binding site [chemical binding]; other site 264732003939 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264732003940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732003941 DNA-binding site [nucleotide binding]; DNA binding site 264732003942 UTRA domain; Region: UTRA; pfam07702 264732003943 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 264732003944 CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308 264732003945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732003946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264732003947 putative substrate translocation pore; other site 264732003948 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732003949 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264732003950 B12 binding site [chemical binding]; other site 264732003951 CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308 264732003952 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 264732003953 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264732003954 substrate binding pocket [chemical binding]; other site 264732003955 dimer interface [polypeptide binding]; other site 264732003956 inhibitor binding site; inhibition site 264732003957 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 264732003958 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264732003959 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264732003960 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264732003961 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 264732003962 GTP-binding protein Der; Reviewed; Region: PRK00093 264732003963 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264732003964 G1 box; other site 264732003965 GTP/Mg2+ binding site [chemical binding]; other site 264732003966 Switch I region; other site 264732003967 G2 box; other site 264732003968 Switch II region; other site 264732003969 G3 box; other site 264732003970 G4 box; other site 264732003971 G5 box; other site 264732003972 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264732003973 G1 box; other site 264732003974 GTP/Mg2+ binding site [chemical binding]; other site 264732003975 Switch I region; other site 264732003976 G2 box; other site 264732003977 G3 box; other site 264732003978 Switch II region; other site 264732003979 G4 box; other site 264732003980 G5 box; other site 264732003981 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 264732003982 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264732003983 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 264732003984 Protein of unknown function (DUF512); Region: DUF512; pfam04459 264732003985 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 264732003986 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 264732003987 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 264732003988 stage II sporulation protein P; Region: spore_II_P; TIGR02867 264732003989 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 264732003990 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 264732003991 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 264732003992 homotetramer interface [polypeptide binding]; other site 264732003993 FMN binding site [chemical binding]; other site 264732003994 homodimer contacts [polypeptide binding]; other site 264732003995 putative active site [active] 264732003996 putative substrate binding site [chemical binding]; other site 264732003997 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 264732003998 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 264732003999 Fe-S cluster binding site [ion binding]; other site 264732004000 substrate binding site [chemical binding]; other site 264732004001 catalytic site [active] 264732004002 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264732004003 RNA binding site [nucleotide binding]; other site 264732004004 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264732004005 RNA binding site [nucleotide binding]; other site 264732004006 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 264732004007 RNA binding site [nucleotide binding]; other site 264732004008 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264732004009 RNA binding site [nucleotide binding]; other site 264732004010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264732004011 putative acyl-acceptor binding pocket; other site 264732004012 cytidylate kinase; Provisional; Region: cmk; PRK00023 264732004013 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264732004014 CMP-binding site; other site 264732004015 The sites determining sugar specificity; other site 264732004016 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 264732004017 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264732004018 hinge; other site 264732004019 active site 264732004020 prephenate dehydrogenase; Validated; Region: PRK08507 264732004021 Prephenate dehydrogenase; Region: PDH; pfam02153 264732004022 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 264732004023 prephenate dehydratase; Provisional; Region: PRK11898 264732004024 Prephenate dehydratase; Region: PDT; pfam00800 264732004025 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264732004026 putative L-Phe binding site [chemical binding]; other site 264732004027 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 264732004028 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 264732004029 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264732004030 substrate binding site [chemical binding]; other site 264732004031 active site 264732004032 catalytic residues [active] 264732004033 heterodimer interface [polypeptide binding]; other site 264732004034 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264732004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732004036 catalytic residue [active] 264732004037 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 264732004038 active site 264732004039 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264732004040 active site 264732004041 ribulose/triose binding site [chemical binding]; other site 264732004042 phosphate binding site [ion binding]; other site 264732004043 substrate (anthranilate) binding pocket [chemical binding]; other site 264732004044 product (indole) binding pocket [chemical binding]; other site 264732004045 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264732004046 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264732004047 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264732004048 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 264732004049 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264732004050 glutamine binding [chemical binding]; other site 264732004051 catalytic triad [active] 264732004052 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 264732004053 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264732004054 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264732004055 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 264732004056 homotrimer interaction site [polypeptide binding]; other site 264732004057 active site 264732004058 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 264732004059 hexamer interface [polypeptide binding]; other site 264732004060 RNA binding site [nucleotide binding]; other site 264732004061 Histidine-zinc binding site [chemical binding]; other site 264732004062 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 264732004063 amino acid transporter; Region: 2A0306; TIGR00909 264732004064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264732004065 Ligand Binding Site [chemical binding]; other site 264732004066 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264732004067 TrkA-N domain; Region: TrkA_N; pfam02254 264732004068 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264732004069 TrkA-N domain; Region: TrkA_N; pfam02254 264732004070 TrkA-C domain; Region: TrkA_C; pfam02080 264732004071 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 264732004072 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 264732004073 ketol-acid reductoisomerase; Provisional; Region: PRK05479 264732004074 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 264732004075 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264732004076 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 264732004077 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 264732004078 homodimer interface [polypeptide binding]; other site 264732004079 Walker A motif; other site 264732004080 ATP binding site [chemical binding]; other site 264732004081 hydroxycobalamin binding site [chemical binding]; other site 264732004082 Walker B motif; other site 264732004083 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264732004084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732004085 RNA binding surface [nucleotide binding]; other site 264732004086 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 264732004087 active site 264732004088 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264732004089 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 264732004090 active site 264732004091 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264732004092 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 264732004093 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264732004094 DNA binding site [nucleotide binding] 264732004095 active site 264732004096 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 264732004097 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 264732004098 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264732004099 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 264732004100 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 264732004101 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 264732004102 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 264732004103 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 264732004104 ScpA/B protein; Region: ScpA_ScpB; cl00598 264732004105 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 264732004106 Peptidase family M50; Region: Peptidase_M50; pfam02163 264732004107 active site 264732004108 putative substrate binding region [chemical binding]; other site 264732004109 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 264732004110 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264732004111 active site 264732004112 NTP binding site [chemical binding]; other site 264732004113 metal binding triad [ion binding]; metal-binding site 264732004114 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264732004115 diaminopimelate decarboxylase; Region: lysA; TIGR01048 264732004116 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264732004117 active site 264732004118 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264732004119 substrate binding site [chemical binding]; other site 264732004120 catalytic residues [active] 264732004121 dimer interface [polypeptide binding]; other site 264732004122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732004123 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264732004124 N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742 264732004125 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 264732004126 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 264732004127 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 264732004128 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 264732004129 active site 264732004130 homotetramer interface [polypeptide binding]; other site 264732004131 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 264732004132 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 264732004133 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264732004134 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 264732004135 active site 264732004136 tetramer interface; other site 264732004137 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 264732004138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 264732004139 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 264732004140 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; cl19245 264732004141 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 264732004142 SpoVA protein; Region: SpoVA; cl04298 264732004143 stage V sporulation protein AD; Validated; Region: PRK08304 264732004144 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 264732004145 SpoVA protein; Region: SpoVA; cl04298 264732004146 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 264732004147 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 264732004148 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 264732004149 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 264732004150 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264732004151 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 264732004152 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732004153 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 264732004154 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264732004155 putative [4Fe-4S] binding site [ion binding]; other site 264732004156 putative molybdopterin cofactor binding site [chemical binding]; other site 264732004157 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 264732004158 molybdopterin cofactor binding site; other site 264732004159 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 264732004160 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732004161 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732004162 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 264732004163 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 264732004164 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732004165 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 264732004166 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 264732004167 putative [Fe4-S4] binding site [ion binding]; other site 264732004168 putative molybdopterin cofactor binding site [chemical binding]; other site 264732004169 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 264732004170 putative molybdopterin cofactor binding site; other site 264732004171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732004172 FeS/SAM binding site; other site 264732004173 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264732004174 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 264732004175 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732004176 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 264732004177 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 264732004178 putative [Fe4-S4] binding site [ion binding]; other site 264732004179 putative molybdopterin cofactor binding site [chemical binding]; other site 264732004180 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 264732004181 putative molybdopterin cofactor binding site; other site 264732004182 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 264732004183 CotJB protein; Region: CotJB; pfam12652 264732004184 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 264732004185 dimanganese center [ion binding]; other site 264732004186 HEPN domain; Region: HEPN; cl00824 264732004187 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 264732004188 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264732004189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732004190 putative Mg++ binding site [ion binding]; other site 264732004191 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732004192 active site 264732004193 NTP binding site [chemical binding]; other site 264732004194 metal binding triad [ion binding]; metal-binding site 264732004195 antibiotic binding site [chemical binding]; other site 264732004196 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264732004197 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 264732004198 Transcriptional regulator [Transcription]; Region: LytR; COG1316 264732004199 Metaviral_G glycoprotein; Region: Metaviral_G; pfam09595 264732004200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 264732004201 DNA binding residues [nucleotide binding] 264732004202 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 264732004203 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 264732004204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 264732004205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732004206 catalytic residue [active] 264732004207 manganese transport transcriptional regulator; Provisional; Region: PRK03902 264732004208 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 264732004209 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264732004210 Nucleoside recognition; Region: Gate; pfam07670 264732004211 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264732004212 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264732004213 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264732004214 G1 box; other site 264732004215 GTP/Mg2+ binding site [chemical binding]; other site 264732004216 Switch I region; other site 264732004217 G2 box; other site 264732004218 G3 box; other site 264732004219 Switch II region; other site 264732004220 G4 box; other site 264732004221 G5 box; other site 264732004222 FeoA domain; Region: FeoA; pfam04023 264732004223 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 264732004224 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 264732004225 P loop nucleotide binding; other site 264732004226 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732004227 switch II; other site 264732004228 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 264732004229 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 264732004230 P loop nucleotide binding; other site 264732004231 switch II; other site 264732004232 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732004233 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732004234 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 264732004235 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 264732004236 FlxA-like protein; Region: FlxA; pfam14282 264732004237 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 264732004238 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264732004239 metal binding site 2 [ion binding]; metal-binding site 264732004240 putative DNA binding helix; other site 264732004241 metal binding site 1 [ion binding]; metal-binding site 264732004242 dimer interface [polypeptide binding]; other site 264732004243 structural Zn2+ binding site [ion binding]; other site 264732004244 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264732004245 trimerization site [polypeptide binding]; other site 264732004246 active site 264732004247 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 264732004248 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 264732004249 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 264732004250 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264732004251 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264732004252 intersubunit interface [polypeptide binding]; other site 264732004253 Uncharacterized conserved protein [Function unknown]; Region: COG2014 264732004254 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 264732004255 Domain of unknown function (DUF364); Region: DUF364; pfam04016 264732004256 O-methyltransferase; Region: Methyltransf_2; pfam00891 264732004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732004258 S-adenosylmethionine binding site [chemical binding]; other site 264732004259 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264732004260 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264732004261 intersubunit interface [polypeptide binding]; other site 264732004262 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264732004263 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264732004264 Walker A/P-loop; other site 264732004265 ATP binding site [chemical binding]; other site 264732004266 Q-loop/lid; other site 264732004267 ABC transporter signature motif; other site 264732004268 Walker B; other site 264732004269 D-loop; other site 264732004270 H-loop/switch region; other site 264732004271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264732004272 ABC-ATPase subunit interface; other site 264732004273 dimer interface [polypeptide binding]; other site 264732004274 putative PBP binding regions; other site 264732004275 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 264732004276 Domain of unknown function (DUF364); Region: DUF364; pfam04016 264732004277 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264732004278 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 264732004279 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 264732004280 Domain of unknown function (DUF364); Region: DUF364; pfam04016 264732004281 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 264732004282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004283 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 264732004284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732004286 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 264732004287 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732004288 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732004289 Zn2+ binding site [ion binding]; other site 264732004290 Mg2+ binding site [ion binding]; other site 264732004291 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 264732004292 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 264732004293 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264732004294 oligomeric interface; other site 264732004295 putative active site [active] 264732004296 homodimer interface [polypeptide binding]; other site 264732004297 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264732004298 putative active site [active] 264732004299 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 264732004300 Domain of unknown function (DUF364); Region: DUF364; pfam04016 264732004301 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 264732004302 CPxP motif; other site 264732004303 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264732004304 putative substrate binding site [chemical binding]; other site 264732004305 putative ATP binding site [chemical binding]; other site 264732004306 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 264732004307 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 264732004308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264732004309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732004310 S-adenosylmethionine binding site [chemical binding]; other site 264732004311 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264732004312 dimer interface [polypeptide binding]; other site 264732004313 putative PBP binding regions; other site 264732004314 ABC-ATPase subunit interface; other site 264732004315 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 264732004316 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 264732004317 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 264732004318 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 264732004319 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 264732004320 B12 binding site [chemical binding]; other site 264732004321 cobalt ligand [ion binding]; other site 264732004322 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 264732004323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732004324 FeS/SAM binding site; other site 264732004325 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 264732004326 ATP cone domain; Region: ATP-cone; pfam03477 264732004327 Class III ribonucleotide reductase; Region: RNR_III; cd01675 264732004328 effector binding site; other site 264732004329 active site 264732004330 Zn binding site [ion binding]; other site 264732004331 glycine loop; other site 264732004332 Helix-Turn-Helix DNA binding domain of putative HspR-like transcription regulators; Region: HTH_HspR-like_MBC; cd04767 264732004333 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264732004334 DNA binding residues [nucleotide binding] 264732004335 putative dimer interface [polypeptide binding]; other site 264732004336 putative metal binding residues [ion binding]; other site 264732004337 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732004338 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732004339 Cysteine-rich domain; Region: CCG; pfam02754 264732004340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264732004341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732004342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004343 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732004344 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 264732004345 4Fe-4S binding domain; Region: Fer4; pfam00037 264732004346 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 264732004347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264732004348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732004351 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 264732004352 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264732004353 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732004354 Walker A/P-loop; other site 264732004355 ATP binding site [chemical binding]; other site 264732004356 Q-loop/lid; other site 264732004357 ABC transporter signature motif; other site 264732004358 Walker B; other site 264732004359 D-loop; other site 264732004360 H-loop/switch region; other site 264732004361 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732004362 Walker A/P-loop; other site 264732004363 ATP binding site [chemical binding]; other site 264732004364 Q-loop/lid; other site 264732004365 ABC transporter signature motif; other site 264732004366 Walker B; other site 264732004367 D-loop; other site 264732004368 H-loop/switch region; other site 264732004369 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 264732004370 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 264732004371 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 264732004372 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 264732004373 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 264732004374 S-layer homology domain; Region: SLH; pfam00395 264732004375 S-layer homology domain; Region: SLH; pfam00395 264732004376 S-layer homology domain; Region: SLH; pfam00395 264732004377 Spore germination protein; Region: Spore_permease; cl17796 264732004378 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 264732004379 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 264732004380 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264732004381 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264732004382 Walker A/P-loop; other site 264732004383 ATP binding site [chemical binding]; other site 264732004384 Q-loop/lid; other site 264732004385 ABC transporter signature motif; other site 264732004386 Walker B; other site 264732004387 D-loop; other site 264732004388 H-loop/switch region; other site 264732004389 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264732004390 ABC-ATPase subunit interface; other site 264732004391 dimer interface [polypeptide binding]; other site 264732004392 putative PBP binding regions; other site 264732004393 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 264732004394 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 264732004395 putative metal binding site [ion binding]; other site 264732004396 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 264732004397 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 264732004398 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 264732004399 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732004400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732004401 Zn2+ binding site [ion binding]; other site 264732004402 Mg2+ binding site [ion binding]; other site 264732004403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732004404 Zn2+ binding site [ion binding]; other site 264732004405 Mg2+ binding site [ion binding]; other site 264732004406 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 264732004407 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 264732004408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732004409 metal binding site [ion binding]; metal-binding site 264732004410 active site 264732004411 I-site; other site 264732004412 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 264732004413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264732004414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732004415 ATP binding site [chemical binding]; other site 264732004416 Mg2+ binding site [ion binding]; other site 264732004417 G-X-G motif; other site 264732004418 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 264732004419 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 264732004420 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264732004421 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264732004422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732004423 dimerization interface [polypeptide binding]; other site 264732004424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264732004425 dimer interface [polypeptide binding]; other site 264732004426 phosphorylation site [posttranslational modification] 264732004427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732004428 ATP binding site [chemical binding]; other site 264732004429 Mg2+ binding site [ion binding]; other site 264732004430 G-X-G motif; other site 264732004431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732004432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732004433 active site 264732004434 phosphorylation site [posttranslational modification] 264732004435 intermolecular recognition site; other site 264732004436 dimerization interface [polypeptide binding]; other site 264732004437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264732004438 DNA binding site [nucleotide binding] 264732004439 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 264732004440 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264732004441 active site 264732004442 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264732004443 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264732004444 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264732004445 Walker A/P-loop; other site 264732004446 ATP binding site [chemical binding]; other site 264732004447 Q-loop/lid; other site 264732004448 ABC transporter signature motif; other site 264732004449 Walker B; other site 264732004450 D-loop; other site 264732004451 H-loop/switch region; other site 264732004452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264732004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732004454 dimer interface [polypeptide binding]; other site 264732004455 conserved gate region; other site 264732004456 putative PBP binding loops; other site 264732004457 ABC-ATPase subunit interface; other site 264732004458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732004459 dimer interface [polypeptide binding]; other site 264732004460 conserved gate region; other site 264732004461 putative PBP binding loops; other site 264732004462 ABC-ATPase subunit interface; other site 264732004463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264732004464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264732004465 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 264732004466 Cache domain; Region: Cache_1; pfam02743 264732004467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732004468 dimerization interface [polypeptide binding]; other site 264732004469 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264732004470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264732004471 dimer interface [polypeptide binding]; other site 264732004472 putative CheW interface [polypeptide binding]; other site 264732004473 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264732004474 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 264732004475 active site 264732004476 DNA binding site [nucleotide binding] 264732004477 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264732004478 DNA binding site [nucleotide binding] 264732004479 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 264732004480 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264732004481 putative DNA binding site [nucleotide binding]; other site 264732004482 putative homodimer interface [polypeptide binding]; other site 264732004483 aspartate aminotransferase; Provisional; Region: PRK05764 264732004484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732004485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732004486 homodimer interface [polypeptide binding]; other site 264732004487 catalytic residue [active] 264732004488 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 264732004489 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264732004490 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264732004491 Dodecin; Region: Dodecin; pfam07311 264732004492 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 264732004493 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264732004494 homotrimer interaction site [polypeptide binding]; other site 264732004495 putative active site [active] 264732004496 sporulation sigma factor SigF; Validated; Region: PRK05572 264732004497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732004498 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264732004499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732004500 DNA binding residues [nucleotide binding] 264732004501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264732004502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732004503 ATP binding site [chemical binding]; other site 264732004504 Mg2+ binding site [ion binding]; other site 264732004505 G-X-G motif; other site 264732004506 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264732004507 anti sigma factor interaction site; other site 264732004508 regulatory phosphorylation site [posttranslational modification]; other site 264732004509 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 264732004510 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 264732004511 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 264732004512 phosphopentomutase; Provisional; Region: PRK05362 264732004513 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264732004514 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264732004515 active site 264732004516 Int/Topo IB signature motif; other site 264732004517 Integral membrane protein DUF95; Region: DUF95; cl00572 264732004518 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 264732004519 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264732004520 dimer interface [polypeptide binding]; other site 264732004521 ADP-ribose binding site [chemical binding]; other site 264732004522 active site 264732004523 nudix motif; other site 264732004524 metal binding site [ion binding]; metal-binding site 264732004525 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 264732004526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732004527 active site 264732004528 phosphorylation site [posttranslational modification] 264732004529 intermolecular recognition site; other site 264732004530 dimerization interface [polypeptide binding]; other site 264732004531 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 264732004532 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 264732004533 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264732004534 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 264732004535 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264732004536 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264732004537 Walker A/P-loop; other site 264732004538 ATP binding site [chemical binding]; other site 264732004539 Q-loop/lid; other site 264732004540 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264732004541 ABC transporter signature motif; other site 264732004542 Walker B; other site 264732004543 D-loop; other site 264732004544 H-loop/switch region; other site 264732004545 arginine repressor; Provisional; Region: PRK04280 264732004546 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 264732004547 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 264732004548 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 264732004549 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 264732004550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732004551 RNA binding surface [nucleotide binding]; other site 264732004552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732004553 S-adenosylmethionine binding site [chemical binding]; other site 264732004554 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264732004555 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264732004556 TPP-binding site; other site 264732004557 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264732004558 PYR/PP interface [polypeptide binding]; other site 264732004559 dimer interface [polypeptide binding]; other site 264732004560 TPP binding site [chemical binding]; other site 264732004561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264732004562 Domain of unknown function DUF21; Region: DUF21; pfam01595 264732004563 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264732004564 substrate binding pocket [chemical binding]; other site 264732004565 chain length determination region; other site 264732004566 substrate-Mg2+ binding site; other site 264732004567 catalytic residues [active] 264732004568 aspartate-rich region 1; other site 264732004569 active site lid residues [active] 264732004570 aspartate-rich region 2; other site 264732004571 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 264732004572 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264732004573 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264732004574 generic binding surface II; other site 264732004575 generic binding surface I; other site 264732004576 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 264732004577 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264732004578 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264732004579 homodimer interface [polypeptide binding]; other site 264732004580 NADP binding site [chemical binding]; other site 264732004581 substrate binding site [chemical binding]; other site 264732004582 putative oxidoreductase; Provisional; Region: PRK12831 264732004583 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 264732004584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732004585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732004586 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 264732004587 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 264732004588 FAD binding pocket [chemical binding]; other site 264732004589 FAD binding motif [chemical binding]; other site 264732004590 phosphate binding motif [ion binding]; other site 264732004591 beta-alpha-beta structure motif; other site 264732004592 NAD binding pocket [chemical binding]; other site 264732004593 Iron coordination center [ion binding]; other site 264732004594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732004595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264732004596 putative substrate translocation pore; other site 264732004597 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 264732004598 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 264732004599 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 264732004600 putative RNA binding site [nucleotide binding]; other site 264732004601 Asp23 family; Region: Asp23; pfam03780 264732004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 264732004603 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264732004604 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264732004605 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264732004606 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264732004607 pyruvate carboxylase subunit B; Validated; Region: PRK09282 264732004608 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 264732004609 active site 264732004610 catalytic residues [active] 264732004611 metal binding site [ion binding]; metal-binding site 264732004612 homodimer binding site [polypeptide binding]; other site 264732004613 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 264732004614 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264732004615 carboxyltransferase (CT) interaction site; other site 264732004616 biotinylation site [posttranslational modification]; other site 264732004617 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264732004618 oligomeric interface; other site 264732004619 putative active site [active] 264732004620 homodimer interface [polypeptide binding]; other site 264732004621 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 264732004622 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264732004623 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 264732004624 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 264732004625 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 264732004626 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 264732004627 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 264732004628 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 264732004629 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 264732004630 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 264732004631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732004632 Walker A motif; other site 264732004633 ATP binding site [chemical binding]; other site 264732004634 Walker B motif; other site 264732004635 elongation factor P; Validated; Region: PRK00529 264732004636 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264732004637 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264732004638 RNA binding site [nucleotide binding]; other site 264732004639 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264732004640 RNA binding site [nucleotide binding]; other site 264732004641 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264732004642 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264732004643 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 264732004644 active site 264732004645 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264732004646 trimer interface [polypeptide binding]; other site 264732004647 active site 264732004648 dimer interface [polypeptide binding]; other site 264732004649 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264732004650 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 264732004651 NPCBM/NEW2 domain; Region: NPCBM; cl07060 264732004652 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264732004653 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 264732004654 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 264732004655 Lipoxygenase; Region: Lipoxygenase; pfam00305 264732004656 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264732004657 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 264732004658 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264732004659 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 264732004660 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 264732004661 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264732004662 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264732004663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 264732004664 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264732004665 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264732004666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264732004667 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264732004668 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264732004669 Walker A motif; other site 264732004670 ATP binding site [chemical binding]; other site 264732004671 Walker B motif; other site 264732004672 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264732004673 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 264732004674 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264732004675 Walker A motif; other site 264732004676 ATP binding site [chemical binding]; other site 264732004677 Walker B motif; other site 264732004678 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264732004679 active site 264732004680 dimer interface [polypeptide binding]; other site 264732004681 metal binding site [ion binding]; metal-binding site 264732004682 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 264732004683 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264732004684 ADP binding site [chemical binding]; other site 264732004685 magnesium binding site [ion binding]; other site 264732004686 putative shikimate binding site; other site 264732004687 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264732004688 Tetramer interface [polypeptide binding]; other site 264732004689 active site 264732004690 FMN-binding site [chemical binding]; other site 264732004691 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264732004692 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264732004693 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264732004694 shikimate binding site; other site 264732004695 NAD(P) binding site [chemical binding]; other site 264732004696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732004697 active site 264732004698 motif I; other site 264732004699 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264732004700 motif II; other site 264732004701 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 264732004702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264732004703 minor groove reading motif; other site 264732004704 helix-hairpin-helix signature motif; other site 264732004705 substrate binding pocket [chemical binding]; other site 264732004706 active site 264732004707 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 264732004708 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264732004709 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 264732004710 catalytic residues [active] 264732004711 catalytic nucleophile [active] 264732004712 Recombinase; Region: Recombinase; pfam07508 264732004713 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 264732004714 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 264732004715 Transposase [DNA replication, recombination, and repair]; Region: COG5421 264732004716 HEPN domain; Region: HEPN; cl00824 264732004717 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732004718 active site 264732004719 NTP binding site [chemical binding]; other site 264732004720 metal binding triad [ion binding]; metal-binding site 264732004721 antibiotic binding site [chemical binding]; other site 264732004722 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 264732004723 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 264732004724 Zn binding site [ion binding]; other site 264732004725 toxin interface [polypeptide binding]; other site 264732004726 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 264732004727 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; cl19358 264732004728 Uncharacterized conserved protein [Function unknown]; Region: COG5663 264732004729 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732004730 HEPN domain; Region: HEPN; pfam05168 264732004731 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732004732 active site 264732004733 NTP binding site [chemical binding]; other site 264732004734 metal binding triad [ion binding]; metal-binding site 264732004735 antibiotic binding site [chemical binding]; other site 264732004736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264732004737 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 264732004738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732004739 ATP binding site [chemical binding]; other site 264732004740 Mg2+ binding site [ion binding]; other site 264732004741 G-X-G motif; other site 264732004742 Accessory gene regulator B; Region: AgrB; pfam04647 264732004743 Protein of unknown function (DUF342); Region: DUF342; cl19219 264732004744 sporulation sigma factor SigK; Reviewed; Region: PRK05803 264732004745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732004747 DNA binding residues [nucleotide binding] 264732004748 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264732004749 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732004750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732004751 Walker A motif; other site 264732004752 ATP binding site [chemical binding]; other site 264732004753 Walker B motif; other site 264732004754 arginine finger; other site 264732004755 Cyclophilin-like; Region: Cyclophil_like; pfam04126 264732004756 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264732004757 active site 264732004758 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264732004759 nucleophile elbow; other site 264732004760 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 264732004761 Cl- selectivity filter; other site 264732004762 Cl- binding residues [ion binding]; other site 264732004763 pore gating glutamate residue; other site 264732004764 dimer interface [polypeptide binding]; other site 264732004765 H+/Cl- coupling transport residue; other site 264732004766 TrkA-C domain; Region: TrkA_C; pfam02080 264732004767 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264732004768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264732004769 NAD(P) binding site [chemical binding]; other site 264732004770 active site 264732004771 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264732004772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732004773 putative substrate translocation pore; other site 264732004774 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 264732004775 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 264732004776 TPP-binding site [chemical binding]; other site 264732004777 putative dimer interface [polypeptide binding]; other site 264732004778 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732004779 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 264732004780 dimer interface [polypeptide binding]; other site 264732004781 PYR/PP interface [polypeptide binding]; other site 264732004782 TPP binding site [chemical binding]; other site 264732004783 substrate binding site [chemical binding]; other site 264732004784 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 264732004785 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 264732004786 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264732004787 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732004788 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 264732004789 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 264732004790 Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933 264732004791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732004792 Walker A motif; other site 264732004793 ATP binding site [chemical binding]; other site 264732004794 Walker B motif; other site 264732004795 arginine finger; other site 264732004796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732004797 Walker A motif; other site 264732004798 ATP binding site [chemical binding]; other site 264732004799 Walker B motif; other site 264732004800 arginine finger; other site 264732004801 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264732004802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732004803 DNA-binding site [nucleotide binding]; DNA binding site 264732004804 FCD domain; Region: FCD; pfam07729 264732004805 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 264732004806 HEAT-like repeat; Region: HEAT_EZ; pfam13513 264732004807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732004808 binding surface 264732004809 TPR motif; other site 264732004810 TPR repeat; Region: TPR_11; pfam13414 264732004811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264732004812 binding surface 264732004813 TPR motif; other site 264732004814 TPR repeat; Region: TPR_11; pfam13414 264732004815 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 264732004816 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 264732004817 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732004818 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732004819 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732004820 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 264732004821 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732004822 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732004823 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 264732004824 Polysulphide reductase, NrfD; Region: NrfD; cl19193 264732004825 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264732004826 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732004827 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732004828 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732004829 Cysteine-rich domain; Region: CCG; pfam02754 264732004830 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 264732004831 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264732004832 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264732004833 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264732004834 catalytic residue [active] 264732004835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732004836 Transposase; Region: HTH_Tnp_1; pfam01527 264732004837 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 264732004838 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 264732004839 Accessory gene regulator B; Region: AgrB; pfam04647 264732004840 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264732004841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732004842 active site 264732004843 phosphorylation site [posttranslational modification] 264732004844 intermolecular recognition site; other site 264732004845 dimerization interface [polypeptide binding]; other site 264732004846 LytTr DNA-binding domain; Region: LytTR; smart00850 264732004847 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 264732004848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732004849 ATP binding site [chemical binding]; other site 264732004850 Mg2+ binding site [ion binding]; other site 264732004851 G-X-G motif; other site 264732004852 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 264732004853 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 264732004854 selenophosphate synthetase; Provisional; Region: PRK00943 264732004855 dimerization interface [polypeptide binding]; other site 264732004856 putative ATP binding site [chemical binding]; other site 264732004857 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264732004858 CPxP motif; other site 264732004859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732004860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732004861 non-specific DNA binding site [nucleotide binding]; other site 264732004862 salt bridge; other site 264732004863 sequence-specific DNA binding site [nucleotide binding]; other site 264732004864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732004865 non-specific DNA binding site [nucleotide binding]; other site 264732004866 salt bridge; other site 264732004867 sequence-specific DNA binding site [nucleotide binding]; other site 264732004868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732004869 non-specific DNA binding site [nucleotide binding]; other site 264732004870 salt bridge; other site 264732004871 sequence-specific DNA binding site [nucleotide binding]; other site 264732004872 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 264732004873 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732004874 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 264732004875 catalytic triad [active] 264732004876 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 264732004877 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732004878 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732004879 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732004880 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732004881 DsrC like protein; Region: DsrC; cl01101 264732004882 DsrC like protein; Region: DsrC; pfam04358 264732004883 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732004884 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732004885 Cysteine-rich domain; Region: CCG; pfam02754 264732004886 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 264732004887 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264732004888 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 264732004889 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 264732004890 CoA binding domain; Region: CoA_binding; pfam02629 264732004891 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264732004892 dimerization interface [polypeptide binding]; other site 264732004893 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 264732004894 VanW like protein; Region: VanW; pfam04294 264732004895 G5 domain; Region: G5; pfam07501 264732004896 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 264732004897 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 264732004898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264732004899 active site 264732004900 catalytic tetrad [active] 264732004901 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732004902 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732004903 hypothetical protein; Provisional; Region: PRK05473 264732004904 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264732004905 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264732004906 motif 1; other site 264732004907 active site 264732004908 motif 2; other site 264732004909 motif 3; other site 264732004910 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264732004911 DHHA1 domain; Region: DHHA1; pfam02272 264732004912 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264732004913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732004914 S-adenosylmethionine binding site [chemical binding]; other site 264732004915 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 264732004916 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 264732004917 putative metal binding site [ion binding]; other site 264732004918 putative dimer interface [polypeptide binding]; other site 264732004919 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264732004920 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 264732004921 PRC-barrel domain; Region: PRC; pfam05239 264732004922 PRC-barrel domain; Region: PRC; pfam05239 264732004923 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 264732004924 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264732004925 Ligand Binding Site [chemical binding]; other site 264732004926 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264732004927 trimerization site [polypeptide binding]; other site 264732004928 active site 264732004929 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264732004930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732004931 catalytic residue [active] 264732004932 Predicted transcriptional regulator [Transcription]; Region: COG1959 264732004933 Rrf2 family protein; Region: rrf2_super; TIGR00738 264732004934 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 264732004935 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264732004936 Walker A motif; other site 264732004937 Vesicle coat trafficking protein Sec16 mid-region; Region: Sec16; pfam12932 264732004938 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 264732004939 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264732004940 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 264732004941 recombination factor protein RarA; Reviewed; Region: PRK13342 264732004942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732004943 Walker A motif; other site 264732004944 ATP binding site [chemical binding]; other site 264732004945 Walker B motif; other site 264732004946 arginine finger; other site 264732004947 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 264732004948 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264732004949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732004950 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264732004951 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264732004952 active site 264732004953 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264732004954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732004955 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 264732004956 charged pocket; other site 264732004957 hydrophobic patch; other site 264732004958 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 264732004959 ThiS interaction site; other site 264732004960 putative active site [active] 264732004961 tetramer interface [polypeptide binding]; other site 264732004962 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 264732004963 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732004964 FeS/SAM binding site; other site 264732004965 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 264732004966 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 264732004967 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 264732004968 catalytic residues [active] 264732004969 Protein of unknown function DUF45; Region: DUF45; cl00636 264732004970 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 264732004971 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264732004972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732004973 ATP binding site [chemical binding]; other site 264732004974 putative Mg++ binding site [ion binding]; other site 264732004975 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264732004976 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 264732004977 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264732004978 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 264732004979 HsdM N-terminal domain; Region: HsdM_N; pfam12161 264732004980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264732004981 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264732004982 catalytic residues [active] 264732004983 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 264732004984 putative homodimer interface [polypeptide binding]; other site 264732004985 putative homotetramer interface [polypeptide binding]; other site 264732004986 putative allosteric switch controlling residues; other site 264732004987 putative metal binding site [ion binding]; other site 264732004988 putative homodimer-homodimer interface [polypeptide binding]; other site 264732004989 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 264732004990 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264732004991 putative ATP binding site [chemical binding]; other site 264732004992 putative substrate interface [chemical binding]; other site 264732004993 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264732004994 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264732004995 dimer interface [polypeptide binding]; other site 264732004996 anticodon binding site; other site 264732004997 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264732004998 homodimer interface [polypeptide binding]; other site 264732004999 motif 1; other site 264732005000 active site 264732005001 motif 2; other site 264732005002 GAD domain; Region: GAD; pfam02938 264732005003 motif 3; other site 264732005004 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264732005005 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264732005006 dimer interface [polypeptide binding]; other site 264732005007 motif 1; other site 264732005008 active site 264732005009 motif 2; other site 264732005010 motif 3; other site 264732005011 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264732005012 anticodon binding site; other site 264732005013 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264732005014 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264732005015 putative active site [active] 264732005016 dimerization interface [polypeptide binding]; other site 264732005017 putative tRNAtyr binding site [nucleotide binding]; other site 264732005018 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264732005019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732005020 Zn2+ binding site [ion binding]; other site 264732005021 Mg2+ binding site [ion binding]; other site 264732005022 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264732005023 synthetase active site [active] 264732005024 NTP binding site [chemical binding]; other site 264732005025 metal binding site [ion binding]; metal-binding site 264732005026 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264732005027 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264732005028 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 264732005029 DHH family; Region: DHH; pfam01368 264732005030 DHHA1 domain; Region: DHHA1; pfam02272 264732005031 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 264732005032 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264732005033 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 264732005034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732005035 dimer interface [polypeptide binding]; other site 264732005036 conserved gate region; other site 264732005037 putative PBP binding loops; other site 264732005038 ABC-ATPase subunit interface; other site 264732005039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732005040 dimer interface [polypeptide binding]; other site 264732005041 conserved gate region; other site 264732005042 putative PBP binding loops; other site 264732005043 ABC-ATPase subunit interface; other site 264732005044 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 264732005045 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 264732005046 Walker A/P-loop; other site 264732005047 ATP binding site [chemical binding]; other site 264732005048 Q-loop/lid; other site 264732005049 ABC transporter signature motif; other site 264732005050 Walker B; other site 264732005051 D-loop; other site 264732005052 H-loop/switch region; other site 264732005053 FOG: CBS domain [General function prediction only]; Region: COG0517 264732005054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 264732005055 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264732005056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732005057 DNA-binding site [nucleotide binding]; DNA binding site 264732005058 TrkA-C domain; Region: TrkA_C; pfam02080 264732005059 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264732005060 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264732005061 Protein export membrane protein; Region: SecD_SecF; pfam02355 264732005062 protein-export membrane protein SecD; Region: secD; TIGR01129 264732005063 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264732005064 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264732005065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 264732005066 Preprotein translocase subunit; Region: YajC; pfam02699 264732005067 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 264732005068 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264732005069 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264732005070 Stage II sporulation protein; Region: SpoIID; pfam08486 264732005071 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 264732005072 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 264732005073 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 264732005074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732005075 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 264732005076 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264732005077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732005078 Walker A motif; other site 264732005079 ATP binding site [chemical binding]; other site 264732005080 Walker B motif; other site 264732005081 arginine finger; other site 264732005082 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264732005083 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264732005084 RuvA N terminal domain; Region: RuvA_N; pfam01330 264732005085 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 264732005086 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264732005087 active site 264732005088 putative DNA-binding cleft [nucleotide binding]; other site 264732005089 dimer interface [polypeptide binding]; other site 264732005090 hypothetical protein; Validated; Region: PRK00110 264732005091 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 264732005092 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264732005093 cysteine synthase; Region: PLN02565 264732005094 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264732005095 dimer interface [polypeptide binding]; other site 264732005096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005097 catalytic residue [active] 264732005098 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 264732005099 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 264732005100 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264732005101 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264732005102 active site 264732005103 HIGH motif; other site 264732005104 dimer interface [polypeptide binding]; other site 264732005105 KMSKS motif; other site 264732005106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732005107 RNA binding surface [nucleotide binding]; other site 264732005108 Transglycosylase; Region: Transgly; pfam00912 264732005109 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264732005110 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264732005111 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264732005112 Interdomain contacts; other site 264732005113 Cytokine receptor motif; other site 264732005114 MutS domain III; Region: MutS_III; pfam05192 264732005115 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264732005116 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 264732005117 Walker A/P-loop; other site 264732005118 ATP binding site [chemical binding]; other site 264732005119 Q-loop/lid; other site 264732005120 ABC transporter signature motif; other site 264732005121 Walker B; other site 264732005122 D-loop; other site 264732005123 H-loop/switch region; other site 264732005124 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 264732005125 Smr domain; Region: Smr; pfam01713 264732005126 putative protease; Provisional; Region: PRK15452 264732005127 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264732005128 Collagenase; Region: DUF3656; pfam12392 264732005129 Peptidase family U32; Region: Peptidase_U32; pfam01136 264732005130 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 264732005131 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732005132 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 264732005133 Putative Fe-S cluster; Region: FeS; cl17515 264732005134 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264732005135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732005136 Walker A motif; other site 264732005137 ATP binding site [chemical binding]; other site 264732005138 Walker B motif; other site 264732005139 arginine finger; other site 264732005140 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264732005141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732005142 non-specific DNA binding site [nucleotide binding]; other site 264732005143 salt bridge; other site 264732005144 sequence-specific DNA binding site [nucleotide binding]; other site 264732005145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732005146 non-specific DNA binding site [nucleotide binding]; other site 264732005147 salt bridge; other site 264732005148 sequence-specific DNA binding site [nucleotide binding]; other site 264732005149 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 264732005150 active site 264732005151 catalytic triad [active] 264732005152 oxyanion hole [active] 264732005153 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732005154 catalytic loop [active] 264732005155 iron binding site [ion binding]; other site 264732005156 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264732005157 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 264732005158 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732005159 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 264732005160 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 264732005161 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 264732005162 dimer interface [polypeptide binding]; other site 264732005163 [2Fe-2S] cluster binding site [ion binding]; other site 264732005164 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264732005165 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 264732005166 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264732005167 4Fe-4S binding domain; Region: Fer4; pfam00037 264732005168 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005169 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732005170 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 264732005171 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264732005172 putative dimer interface [polypeptide binding]; other site 264732005173 [2Fe-2S] cluster binding site [ion binding]; other site 264732005174 O-methyltransferase; Region: Methyltransf_2; pfam00891 264732005175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732005176 S-adenosylmethionine binding site [chemical binding]; other site 264732005177 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264732005178 putative dimer interface [polypeptide binding]; other site 264732005179 active site pocket [active] 264732005180 putative cataytic base [active] 264732005181 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 264732005182 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 264732005183 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 264732005184 Transposase [DNA replication, recombination, and repair]; Region: COG5421 264732005185 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 264732005186 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 264732005187 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 264732005188 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 264732005189 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264732005190 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 264732005191 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl18995 264732005192 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 264732005193 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl18979 264732005194 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 264732005195 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 264732005196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005197 FeS/SAM binding site; other site 264732005198 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 264732005199 biotin synthase; Provisional; Region: PRK07094 264732005200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005201 FeS/SAM binding site; other site 264732005202 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 264732005203 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 264732005204 DNA adenine methylase (dam); Region: dam; TIGR00571 264732005205 6-phosphofructokinase; Provisional; Region: PRK03202 264732005206 active site 264732005207 ADP/pyrophosphate binding site [chemical binding]; other site 264732005208 dimerization interface [polypeptide binding]; other site 264732005209 allosteric effector site; other site 264732005210 fructose-1,6-bisphosphate binding site; other site 264732005211 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 264732005212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 264732005213 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264732005214 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264732005215 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 264732005216 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264732005217 ligand binding site [chemical binding]; other site 264732005218 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 264732005219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 264732005220 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 264732005221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264732005222 nucleotide binding site [chemical binding]; other site 264732005223 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264732005224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732005225 RNA binding surface [nucleotide binding]; other site 264732005226 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 264732005227 active site 264732005228 uracil binding [chemical binding]; other site 264732005229 Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577 264732005230 active site 264732005231 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 264732005232 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 264732005233 AAA ATPase domain; Region: AAA_16; pfam13191 264732005234 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 264732005235 active site 264732005236 metal binding site [ion binding]; metal-binding site 264732005237 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 264732005238 hypothetical protein; Provisional; Region: PRK08609 264732005239 active site 264732005240 primer binding site [nucleotide binding]; other site 264732005241 NTP binding site [chemical binding]; other site 264732005242 metal binding triad [ion binding]; metal-binding site 264732005243 DNA polymerase beta thumb; Region: DNA_pol_B_thumb; pfam14791 264732005244 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 264732005245 active site 264732005246 Cell division protein ZapA; Region: ZapA; pfam05164 264732005247 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264732005248 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264732005249 putative tRNA-binding site [nucleotide binding]; other site 264732005250 B3/4 domain; Region: B3_4; pfam03483 264732005251 tRNA synthetase B5 domain; Region: B5; smart00874 264732005252 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264732005253 motif 1; other site 264732005254 dimer interface [polypeptide binding]; other site 264732005255 motif 3; other site 264732005256 motif 2; other site 264732005257 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 264732005258 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264732005259 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264732005260 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264732005261 dimer interface [polypeptide binding]; other site 264732005262 motif 1; other site 264732005263 active site 264732005264 motif 2; other site 264732005265 motif 3; other site 264732005266 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 264732005267 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264732005268 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 264732005269 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264732005270 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264732005271 TrkA-N domain; Region: TrkA_N; pfam02254 264732005272 TrkA-C domain; Region: TrkA_C; pfam02080 264732005273 Cation transport protein; Region: TrkH; cl17365 264732005274 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 264732005275 Cation transport protein; Region: TrkH; pfam02386 264732005276 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264732005277 23S rRNA binding site [nucleotide binding]; other site 264732005278 L21 binding site [polypeptide binding]; other site 264732005279 L13 binding site [polypeptide binding]; other site 264732005280 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264732005281 translation initiation factor IF-3; Region: infC; TIGR00168 264732005282 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264732005283 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264732005284 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264732005285 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264732005286 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264732005287 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264732005288 active site 264732005289 dimer interface [polypeptide binding]; other site 264732005290 motif 1; other site 264732005291 motif 2; other site 264732005292 motif 3; other site 264732005293 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264732005294 anticodon binding site; other site 264732005295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 264732005296 YtxC-like family; Region: YtxC; pfam08812 264732005297 lipoyl synthase; Provisional; Region: PRK05481 264732005298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005299 FeS/SAM binding site; other site 264732005300 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 264732005301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732005302 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 264732005303 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 264732005304 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264732005305 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264732005306 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 264732005307 active site 264732005308 hypothetical protein; Provisional; Region: PRK06851 264732005309 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 264732005310 putative active site [active] 264732005311 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264732005312 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264732005313 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264732005314 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264732005315 active site 264732005316 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 264732005317 Sulfate transporter family; Region: Sulfate_transp; cl19250 264732005318 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005319 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005320 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264732005321 4-hydroxy-2-oxovalerate aldolase; Region: 4OH_2_O_val_ald; TIGR03217 264732005322 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 264732005323 active site 264732005324 catalytic residues [active] 264732005325 metal binding site [ion binding]; metal-binding site 264732005326 DmpG-like communication domain; Region: DmpG_comm; pfam07836 264732005327 acetaldehyde dehydrogenase; Validated; Region: PRK08300 264732005328 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 264732005329 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 264732005330 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264732005331 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 264732005332 MPT binding site; other site 264732005333 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 264732005334 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 264732005335 active site 264732005336 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264732005337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264732005338 Bacterial transcriptional regulator; Region: IclR; pfam01614 264732005339 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 264732005340 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 264732005341 active site 264732005342 Coat F domain; Region: Coat_F; pfam07875 264732005343 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 264732005344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264732005345 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 264732005346 inhibitor-cofactor binding pocket; inhibition site 264732005347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005348 catalytic residue [active] 264732005349 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 264732005350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005351 FeS/SAM binding site; other site 264732005352 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 264732005353 AAA domain; Region: AAA_23; pfam13476 264732005354 Walker A/P-loop; other site 264732005355 ATP binding site [chemical binding]; other site 264732005356 Ciliary protein causing Leber congenital amaurosis disease; Region: Lebercilin; pfam15619 264732005357 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 264732005358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732005359 Q-loop/lid; other site 264732005360 ABC transporter signature motif; other site 264732005361 Walker B; other site 264732005362 D-loop; other site 264732005363 H-loop/switch region; other site 264732005364 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264732005365 active site 264732005366 metal binding site [ion binding]; metal-binding site 264732005367 DNA binding site [nucleotide binding] 264732005368 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732005369 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 264732005370 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 264732005371 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 264732005372 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264732005373 TrkA-N domain; Region: TrkA_N; pfam02254 264732005374 TrkA-C domain; Region: TrkA_C; pfam02080 264732005375 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264732005376 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 264732005377 CoenzymeA binding site [chemical binding]; other site 264732005378 subunit interaction site [polypeptide binding]; other site 264732005379 PHB binding site; other site 264732005380 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264732005381 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 264732005382 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 264732005383 Int/Topo IB signature motif; other site 264732005384 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 264732005385 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 264732005386 toxin interface [polypeptide binding]; other site 264732005387 Zn binding site [ion binding]; other site 264732005388 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 264732005389 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 264732005390 Extracellular matrix protein 1 (ECM1); Region: ECM1; pfam05782 264732005391 CHC2 zinc finger; Region: zf-CHC2; cl17510 264732005392 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 264732005393 active site 264732005394 metal binding site [ion binding]; metal-binding site 264732005395 interdomain interaction site; other site 264732005396 DsrC like protein; Region: DsrC; cl01101 264732005397 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 264732005398 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 264732005399 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 264732005400 catalytic site [active] 264732005401 active site 264732005402 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264732005403 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 264732005404 active site 264732005405 catalytic site [active] 264732005406 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 264732005407 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 264732005408 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 264732005409 active site 264732005410 catalytic site [active] 264732005411 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 264732005412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732005413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264732005414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264732005415 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 264732005416 active site 264732005417 YmaF family; Region: YmaF; pfam12788 264732005418 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 264732005419 putative active site [active] 264732005420 Mn binding site [ion binding]; other site 264732005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732005422 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264732005423 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264732005424 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264732005425 PhoU domain; Region: PhoU; pfam01895 264732005426 PhoU domain; Region: PhoU; pfam01895 264732005427 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 264732005428 PhoU domain; Region: PhoU; pfam01895 264732005429 PhoU domain; Region: PhoU; pfam01895 264732005430 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 264732005431 Walker A motif; other site 264732005432 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264732005433 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264732005434 dimer interface [polypeptide binding]; other site 264732005435 putative functional site; other site 264732005436 putative MPT binding site; other site 264732005437 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 264732005438 active site 264732005439 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264732005440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732005441 Walker A/P-loop; other site 264732005442 ATP binding site [chemical binding]; other site 264732005443 Q-loop/lid; other site 264732005444 ABC transporter signature motif; other site 264732005445 Walker B; other site 264732005446 D-loop; other site 264732005447 H-loop/switch region; other site 264732005448 TOBE domain; Region: TOBE; pfam03459 264732005449 TOBE domain; Region: TOBE_2; pfam08402 264732005450 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264732005451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732005452 dimer interface [polypeptide binding]; other site 264732005453 conserved gate region; other site 264732005454 putative PBP binding loops; other site 264732005455 ABC-ATPase subunit interface; other site 264732005456 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 264732005457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264732005458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264732005459 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264732005460 putative dimerization interface [polypeptide binding]; other site 264732005461 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 264732005462 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 264732005463 NAD binding site [chemical binding]; other site 264732005464 dimer interface [polypeptide binding]; other site 264732005465 substrate binding site [chemical binding]; other site 264732005466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264732005467 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732005468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732005469 non-specific DNA binding site [nucleotide binding]; other site 264732005470 salt bridge; other site 264732005471 sequence-specific DNA binding site [nucleotide binding]; other site 264732005472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732005473 non-specific DNA binding site [nucleotide binding]; other site 264732005474 salt bridge; other site 264732005475 sequence-specific DNA binding site [nucleotide binding]; other site 264732005476 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264732005477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732005478 non-specific DNA binding site [nucleotide binding]; other site 264732005479 salt bridge; other site 264732005480 sequence-specific DNA binding site [nucleotide binding]; other site 264732005481 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 264732005482 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264732005483 catalytic residues [active] 264732005484 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 264732005485 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264732005486 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 264732005487 DXD motif; other site 264732005488 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 264732005489 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005490 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 264732005491 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 264732005492 FMN binding site [chemical binding]; other site 264732005493 dimer interface [polypeptide binding]; other site 264732005494 Putative amidase domain; Region: Amidase_6; pfam12671 264732005495 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 264732005496 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 264732005497 active site 264732005498 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264732005499 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264732005500 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264732005501 catalytic residue [active] 264732005502 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264732005503 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264732005504 CoA-binding site [chemical binding]; other site 264732005505 ATP-binding [chemical binding]; other site 264732005506 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 264732005507 Domain of unknown function DUF; Region: DUF204; pfam02659 264732005508 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264732005509 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264732005510 DNA binding site [nucleotide binding] 264732005511 catalytic residue [active] 264732005512 H2TH interface [polypeptide binding]; other site 264732005513 putative catalytic residues [active] 264732005514 turnover-facilitating residue; other site 264732005515 intercalation triad [nucleotide binding]; other site 264732005516 8OG recognition residue [nucleotide binding]; other site 264732005517 putative reading head residues; other site 264732005518 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264732005519 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264732005520 DNA polymerase I; Provisional; Region: PRK05755 264732005521 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264732005522 active site 264732005523 metal binding site 1 [ion binding]; metal-binding site 264732005524 putative 5' ssDNA interaction site; other site 264732005525 metal binding site 3; metal-binding site 264732005526 metal binding site 2 [ion binding]; metal-binding site 264732005527 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264732005528 putative DNA binding site [nucleotide binding]; other site 264732005529 putative metal binding site [ion binding]; other site 264732005530 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 264732005531 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264732005532 active site 264732005533 DNA binding site [nucleotide binding] 264732005534 catalytic site [active] 264732005535 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 264732005536 Putative zinc-finger; Region: zf-HC2; pfam13490 264732005537 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 264732005538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732005539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732005540 DNA binding residues [nucleotide binding] 264732005541 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 264732005542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005543 FeS/SAM binding site; other site 264732005544 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 264732005545 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 264732005546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732005547 FeS/SAM binding site; other site 264732005548 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 264732005549 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 264732005550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264732005551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264732005552 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 264732005553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264732005554 EamA-like transporter family; Region: EamA; pfam00892 264732005555 EamA-like transporter family; Region: EamA; pfam00892 264732005556 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 264732005557 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 264732005558 FOG: CBS domain [General function prediction only]; Region: COG0517 264732005559 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264732005560 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 264732005561 putative homodimer interface [polypeptide binding]; other site 264732005562 putative active site pocket [active] 264732005563 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 264732005564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732005565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264732005566 Uncharacterized conserved protein [Function unknown]; Region: COG1543 264732005567 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 264732005568 active site 264732005569 substrate binding site [chemical binding]; other site 264732005570 catalytic site [active] 264732005571 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 264732005572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 264732005573 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 264732005574 homodimer interface [polypeptide binding]; other site 264732005575 maltodextrin glucosidase; Provisional; Region: PRK10785 264732005576 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 264732005577 active site 264732005578 homodimer interface [polypeptide binding]; other site 264732005579 catalytic site [active] 264732005580 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 264732005581 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732005582 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 264732005583 putative active site [active] 264732005584 putative metal binding site [ion binding]; other site 264732005585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732005586 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732005587 putative Zn2+ binding site [ion binding]; other site 264732005588 putative DNA binding site [nucleotide binding]; other site 264732005589 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264732005590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732005591 putative substrate translocation pore; other site 264732005592 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264732005593 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732005594 Walker A/P-loop; other site 264732005595 ATP binding site [chemical binding]; other site 264732005596 Q-loop/lid; other site 264732005597 ABC transporter signature motif; other site 264732005598 Walker B; other site 264732005599 D-loop; other site 264732005600 H-loop/switch region; other site 264732005601 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 264732005602 cobalt transport protein CbiM; Provisional; Region: PRK07331 264732005603 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 264732005604 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 264732005605 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 264732005606 putative active site [active] 264732005607 septum formation inhibitor; Reviewed; Region: minC; PRK00513 264732005608 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 264732005609 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 264732005610 pyruvate kinase; Provisional; Region: PRK06354 264732005611 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 264732005612 domain interfaces; other site 264732005613 active site 264732005614 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 264732005615 6-phosphofructokinase; Provisional; Region: PRK03202 264732005616 active site 264732005617 ADP/pyrophosphate binding site [chemical binding]; other site 264732005618 dimerization interface [polypeptide binding]; other site 264732005619 allosteric effector site; other site 264732005620 fructose-1,6-bisphosphate binding site; other site 264732005621 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 264732005622 transcription attenuation protein MtrB; Provisional; Region: PRK13251 264732005623 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264732005624 active site 264732005625 (T/H)XGH motif; other site 264732005626 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 264732005627 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 264732005628 active site 264732005629 PHP Thumb interface [polypeptide binding]; other site 264732005630 metal binding site [ion binding]; metal-binding site 264732005631 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264732005632 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 264732005633 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264732005634 generic binding surface II; other site 264732005635 generic binding surface I; other site 264732005636 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 264732005637 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 264732005638 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264732005639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264732005640 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 264732005641 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264732005642 putative dimerization interface [polypeptide binding]; other site 264732005643 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264732005644 Rubrerythrin [Energy production and conversion]; Region: COG1592 264732005645 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 264732005646 diiron binding motif [ion binding]; other site 264732005647 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 264732005648 Protein of unknown function (DUF503); Region: DUF503; pfam04456 264732005649 aconitate hydratase; Validated; Region: PRK07229 264732005650 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 264732005651 substrate binding site [chemical binding]; other site 264732005652 ligand binding site [chemical binding]; other site 264732005653 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 264732005654 substrate binding site [chemical binding]; other site 264732005655 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 264732005656 4Fe-4S binding domain; Region: Fer4; pfam00037 264732005657 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005658 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 264732005659 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 264732005660 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 264732005661 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005662 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005663 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 264732005664 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264732005665 putative dimer interface [polypeptide binding]; other site 264732005666 [2Fe-2S] cluster binding site [ion binding]; other site 264732005667 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 264732005668 dimer interface [polypeptide binding]; other site 264732005669 [2Fe-2S] cluster binding site [ion binding]; other site 264732005670 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264732005671 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 264732005672 SLBB domain; Region: SLBB; pfam10531 264732005673 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264732005674 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732005675 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732005677 catalytic loop [active] 264732005678 iron binding site [ion binding]; other site 264732005679 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264732005680 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732005681 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732005682 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264732005683 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732005684 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732005685 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 264732005686 Putative Fe-S cluster; Region: FeS; cl17515 264732005687 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264732005688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732005689 Walker A motif; other site 264732005690 ATP binding site [chemical binding]; other site 264732005691 Walker B motif; other site 264732005692 arginine finger; other site 264732005693 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264732005694 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732005695 Ferredoxin [Energy production and conversion]; Region: COG1146 264732005696 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 264732005697 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264732005698 minor groove reading motif; other site 264732005699 helix-hairpin-helix signature motif; other site 264732005700 substrate binding pocket [chemical binding]; other site 264732005701 active site 264732005702 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 264732005703 OsmC-like protein; Region: OsmC; cl00767 264732005704 OsmC-like protein; Region: OsmC; pfam02566 264732005705 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 264732005706 active site 264732005707 substrate-binding site [chemical binding]; other site 264732005708 metal-binding site [ion binding] 264732005709 ATP binding site [chemical binding]; other site 264732005710 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264732005711 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264732005712 G1 box; other site 264732005713 putative GEF interaction site [polypeptide binding]; other site 264732005714 GTP/Mg2+ binding site [chemical binding]; other site 264732005715 Switch I region; other site 264732005716 G2 box; other site 264732005717 G3 box; other site 264732005718 Switch II region; other site 264732005719 G4 box; other site 264732005720 G5 box; other site 264732005721 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264732005722 Elongation Factor G, domain II; Region: EFG_II; pfam14492 264732005723 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264732005724 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 264732005725 Cupin domain; Region: Cupin_2; pfam07883 264732005726 Uncharacterized conserved protein [Function unknown]; Region: COG3189 264732005727 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264732005728 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264732005729 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264732005730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732005731 Walker A/P-loop; other site 264732005732 ATP binding site [chemical binding]; other site 264732005733 Q-loop/lid; other site 264732005734 ABC transporter signature motif; other site 264732005735 Walker B; other site 264732005736 D-loop; other site 264732005737 H-loop/switch region; other site 264732005738 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 264732005739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264732005740 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264732005741 Walker A/P-loop; other site 264732005742 ATP binding site [chemical binding]; other site 264732005743 Q-loop/lid; other site 264732005744 ABC transporter signature motif; other site 264732005745 Walker B; other site 264732005746 D-loop; other site 264732005747 H-loop/switch region; other site 264732005748 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 264732005749 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264732005750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732005751 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732005752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264732005753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264732005754 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 264732005755 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264732005756 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 264732005757 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005758 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264732005759 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 264732005760 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264732005761 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 264732005762 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 264732005763 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 264732005764 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 264732005765 [4Fe-4S] binding site [ion binding]; other site 264732005766 molybdopterin cofactor binding site [chemical binding]; other site 264732005767 The MopB_CT_4 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_4; cd02785 264732005768 putative molybdopterin cofactor binding site; other site 264732005769 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264732005770 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 264732005771 [4Fe-4S] binding site [ion binding]; other site 264732005772 molybdopterin cofactor binding site; other site 264732005773 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264732005774 molybdopterin cofactor binding site; other site 264732005775 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264732005776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732005777 putative active site [active] 264732005778 heme pocket [chemical binding]; other site 264732005779 Protein of unknown function DUF45; Region: DUF45; cl00636 264732005780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732005781 Walker A motif; other site 264732005782 ATP binding site [chemical binding]; other site 264732005783 Walker B motif; other site 264732005784 arginine finger; other site 264732005785 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264732005786 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 264732005787 putative active site [active] 264732005788 metal binding site [ion binding]; metal-binding site 264732005789 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264732005790 TRAM domain; Region: TRAM; pfam01938 264732005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732005792 S-adenosylmethionine binding site [chemical binding]; other site 264732005793 CAAX protease self-immunity; Region: Abi; pfam02517 264732005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 264732005795 Uncharacterized conserved protein [Function unknown]; Region: COG1543 264732005796 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 264732005797 active site 264732005798 substrate binding site [chemical binding]; other site 264732005799 catalytic site [active] 264732005800 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 264732005801 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264732005802 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264732005803 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264732005804 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 264732005805 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 264732005806 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264732005807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264732005808 ATP binding site [chemical binding]; other site 264732005809 putative Mg++ binding site [ion binding]; other site 264732005810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264732005811 nucleotide binding region [chemical binding]; other site 264732005812 ATP-binding site [chemical binding]; other site 264732005813 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264732005814 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264732005815 active site 264732005816 HIGH motif; other site 264732005817 dimer interface [polypeptide binding]; other site 264732005818 KMSKS motif; other site 264732005819 amino acid transporter; Region: 2A0306; TIGR00909 264732005820 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 264732005821 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 264732005822 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 264732005823 TPP-binding site [chemical binding]; other site 264732005824 putative dimer interface [polypeptide binding]; other site 264732005825 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 264732005826 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732005827 dimer interface [polypeptide binding]; other site 264732005828 PYR/PP interface [polypeptide binding]; other site 264732005829 TPP binding site [chemical binding]; other site 264732005830 substrate binding site [chemical binding]; other site 264732005831 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005832 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264732005833 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264732005834 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264732005835 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 264732005836 active site 264732005837 Substrate binding site; other site 264732005838 Mg++ binding site; other site 264732005839 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264732005840 putative trimer interface [polypeptide binding]; other site 264732005841 putative CoA binding site [chemical binding]; other site 264732005842 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 264732005843 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 264732005844 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 264732005845 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 264732005846 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 264732005847 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 264732005848 amino acid transporter; Region: 2A0306; TIGR00909 264732005849 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 264732005850 Uncharacterized conserved protein [Function unknown]; Region: COG2461 264732005851 Family of unknown function (DUF438); Region: DUF438; pfam04282 264732005852 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 264732005853 MarC family integral membrane protein; Region: MarC; pfam01914 264732005854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264732005855 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264732005856 ADP-glucose phosphorylase; Region: PLN02643 264732005857 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264732005858 nucleotide binding site/active site [active] 264732005859 HIT family signature motif; other site 264732005860 catalytic residue [active] 264732005861 glycogen synthase; Provisional; Region: glgA; PRK00654 264732005862 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 264732005863 ADP-binding pocket [chemical binding]; other site 264732005864 homodimer interface [polypeptide binding]; other site 264732005865 Carbohydrate binding domain; Region: CBM_25; smart01066 264732005866 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 264732005867 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 264732005868 active site 264732005869 catalytic residues [active] 264732005870 metal binding site [ion binding]; metal-binding site 264732005871 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264732005872 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 264732005873 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264732005874 tetramer interface [polypeptide binding]; other site 264732005875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005876 catalytic residue [active] 264732005877 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264732005878 tetramer interface [polypeptide binding]; other site 264732005879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005880 catalytic residue [active] 264732005881 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264732005882 lipoyl attachment site [posttranslational modification]; other site 264732005883 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264732005884 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 264732005885 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264732005886 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264732005887 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 264732005888 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 264732005889 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264732005890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264732005891 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 264732005892 putative substrate binding site [chemical binding]; other site 264732005893 nucleotide binding site [chemical binding]; other site 264732005894 nucleotide binding site [chemical binding]; other site 264732005895 homodimer interface [polypeptide binding]; other site 264732005896 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 264732005897 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264732005898 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 264732005899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732005900 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732005901 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264732005902 TM-ABC transporter signature motif; other site 264732005903 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264732005904 TM-ABC transporter signature motif; other site 264732005905 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264732005906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264732005907 Walker A/P-loop; other site 264732005908 ATP binding site [chemical binding]; other site 264732005909 Q-loop/lid; other site 264732005910 ABC transporter signature motif; other site 264732005911 Walker B; other site 264732005912 D-loop; other site 264732005913 H-loop/switch region; other site 264732005914 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264732005915 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264732005916 putative ligand binding site [chemical binding]; other site 264732005917 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264732005918 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 264732005919 dimerization interface [polypeptide binding]; other site 264732005920 ligand binding site [chemical binding]; other site 264732005921 NADP binding site [chemical binding]; other site 264732005922 catalytic site [active] 264732005923 aspartate aminotransferase; Provisional; Region: PRK05764 264732005924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264732005925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005926 homodimer interface [polypeptide binding]; other site 264732005927 catalytic residue [active] 264732005928 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 264732005929 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264732005930 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264732005931 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 264732005932 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264732005933 active site 264732005934 putative substrate binding pocket [chemical binding]; other site 264732005935 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264732005936 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732005937 catalytic loop [active] 264732005938 iron binding site [ion binding]; other site 264732005939 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264732005940 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 264732005941 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 264732005942 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264732005943 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 264732005944 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264732005945 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264732005946 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 264732005947 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732005948 catalytic loop [active] 264732005949 iron binding site [ion binding]; other site 264732005950 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264732005951 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264732005952 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 264732005953 metal binding site [ion binding]; metal-binding site 264732005954 dimer interface [polypeptide binding]; other site 264732005955 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 264732005956 Carbon starvation protein CstA; Region: CstA; pfam02554 264732005957 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 264732005958 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264732005959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732005960 active site 264732005961 phosphorylation site [posttranslational modification] 264732005962 intermolecular recognition site; other site 264732005963 dimerization interface [polypeptide binding]; other site 264732005964 LytTr DNA-binding domain; Region: LytTR; smart00850 264732005965 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 264732005966 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 264732005967 GAF domain; Region: GAF_3; pfam13492 264732005968 Histidine kinase; Region: His_kinase; pfam06580 264732005969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732005970 ATP binding site [chemical binding]; other site 264732005971 Mg2+ binding site [ion binding]; other site 264732005972 G-X-G motif; other site 264732005973 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 264732005974 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264732005975 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264732005976 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264732005977 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264732005978 CPxP motif; other site 264732005979 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 264732005980 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264732005981 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 264732005982 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005983 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 264732005984 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 264732005985 ATP binding site [chemical binding]; other site 264732005986 substrate interface [chemical binding]; other site 264732005987 cysteine synthase; Region: PLN02565 264732005988 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264732005989 dimer interface [polypeptide binding]; other site 264732005990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732005991 catalytic residue [active] 264732005992 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732005993 ACS interaction site; other site 264732005994 CODH interaction site; other site 264732005995 metal cluster binding site [ion binding]; other site 264732005996 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264732005997 NMT1-like family; Region: NMT1_2; pfam13379 264732005998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264732005999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732006000 dimer interface [polypeptide binding]; other site 264732006001 conserved gate region; other site 264732006002 putative PBP binding loops; other site 264732006003 ABC-ATPase subunit interface; other site 264732006004 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264732006005 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264732006006 Walker A/P-loop; other site 264732006007 ATP binding site [chemical binding]; other site 264732006008 Q-loop/lid; other site 264732006009 ABC transporter signature motif; other site 264732006010 Walker B; other site 264732006011 D-loop; other site 264732006012 H-loop/switch region; other site 264732006013 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 264732006014 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264732006015 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 264732006016 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264732006017 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264732006018 Walker A/P-loop; other site 264732006019 ATP binding site [chemical binding]; other site 264732006020 Q-loop/lid; other site 264732006021 ABC transporter signature motif; other site 264732006022 Walker B; other site 264732006023 D-loop; other site 264732006024 H-loop/switch region; other site 264732006025 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264732006026 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 264732006027 acyl-activating enzyme (AAE) consensus motif; other site 264732006028 putative AMP binding site [chemical binding]; other site 264732006029 putative active site [active] 264732006030 putative CoA binding site [chemical binding]; other site 264732006031 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264732006032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264732006033 substrate binding pocket [chemical binding]; other site 264732006034 membrane-bound complex binding site; other site 264732006035 hinge residues; other site 264732006036 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264732006037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264732006038 dimer interface [polypeptide binding]; other site 264732006039 conserved gate region; other site 264732006040 putative PBP binding loops; other site 264732006041 ABC-ATPase subunit interface; other site 264732006042 Ferredoxin [Energy production and conversion]; Region: COG1146 264732006043 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732006044 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 264732006045 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732006046 dimer interface [polypeptide binding]; other site 264732006047 PYR/PP interface [polypeptide binding]; other site 264732006048 TPP binding site [chemical binding]; other site 264732006049 substrate binding site [chemical binding]; other site 264732006050 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 264732006051 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264732006052 TPP-binding site [chemical binding]; other site 264732006053 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264732006054 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264732006055 homodimer interface [polypeptide binding]; other site 264732006056 substrate-cofactor binding pocket; other site 264732006057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006058 catalytic residue [active] 264732006059 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264732006060 homodimer interface [polypeptide binding]; other site 264732006061 substrate-cofactor binding pocket; other site 264732006062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006063 catalytic residue [active] 264732006064 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 264732006065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264732006066 metal-binding site [ion binding] 264732006067 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264732006068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264732006069 metal-binding site [ion binding] 264732006070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264732006071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732006072 motif II; other site 264732006073 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 264732006074 putative active site [active] 264732006075 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 264732006076 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264732006077 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264732006078 phenylhydantoinase; Validated; Region: PRK08323 264732006079 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 264732006080 tetramer interface [polypeptide binding]; other site 264732006081 active site 264732006082 threonine synthase; Validated; Region: PRK06260 264732006083 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 264732006084 homodimer interface [polypeptide binding]; other site 264732006085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006086 catalytic residue [active] 264732006087 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 264732006088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732006089 catalytic loop [active] 264732006090 iron binding site [ion binding]; other site 264732006091 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264732006092 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264732006093 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264732006094 cysteine synthase; Region: PLN02565 264732006095 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264732006096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732006097 catalytic residue [active] 264732006098 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 264732006099 tetramer interfaces [polypeptide binding]; other site 264732006100 binuclear metal-binding site [ion binding]; other site 264732006101 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 264732006102 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 264732006103 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 264732006104 Ligand binding site; other site 264732006105 metal-binding site 264732006106 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 264732006107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264732006108 non-specific DNA binding site [nucleotide binding]; other site 264732006109 salt bridge; other site 264732006110 sequence-specific DNA binding site [nucleotide binding]; other site 264732006111 Cupin domain; Region: Cupin_2; pfam07883 264732006112 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264732006113 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264732006114 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264732006115 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264732006116 pyrophosphatase PpaX; Provisional; Region: PRK13288 264732006117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732006118 active site 264732006119 motif I; other site 264732006120 motif II; other site 264732006121 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264732006122 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264732006123 GatB domain; Region: GatB_Yqey; smart00845 264732006124 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 264732006125 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 264732006126 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 264732006127 putative active site [active] 264732006128 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 264732006129 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264732006130 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264732006131 nucleotide binding pocket [chemical binding]; other site 264732006132 K-X-D-G motif; other site 264732006133 catalytic site [active] 264732006134 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264732006135 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264732006136 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 264732006137 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 264732006138 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264732006139 Dimer interface [polypeptide binding]; other site 264732006140 BRCT sequence motif; other site 264732006141 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 264732006142 Part of AAA domain; Region: AAA_19; pfam13245 264732006143 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 264732006144 Coat F domain; Region: Coat_F; pfam07875 264732006145 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 264732006146 substrate binding site [chemical binding]; other site 264732006147 multimerization interface [polypeptide binding]; other site 264732006148 ATP binding site [chemical binding]; other site 264732006149 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264732006150 active site 264732006151 FMN binding site [chemical binding]; other site 264732006152 substrate binding site [chemical binding]; other site 264732006153 3Fe-4S cluster binding site [ion binding]; other site 264732006154 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 264732006155 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264732006156 TM-ABC transporter signature motif; other site 264732006157 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 264732006158 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264732006159 Walker A/P-loop; other site 264732006160 ATP binding site [chemical binding]; other site 264732006161 Q-loop/lid; other site 264732006162 ABC transporter signature motif; other site 264732006163 Walker B; other site 264732006164 D-loop; other site 264732006165 H-loop/switch region; other site 264732006166 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264732006167 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 264732006168 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 264732006169 putative ligand binding site [chemical binding]; other site 264732006170 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 264732006171 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264732006172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264732006173 DNA binding site [nucleotide binding] 264732006174 domain linker motif; other site 264732006175 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264732006176 dimerization interface [polypeptide binding]; other site 264732006177 ligand binding site [chemical binding]; other site 264732006178 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 264732006179 N- and C-terminal domain interface [polypeptide binding]; other site 264732006180 D-xylulose kinase; Region: XylB; TIGR01312 264732006181 active site 264732006182 MgATP binding site [chemical binding]; other site 264732006183 catalytic site [active] 264732006184 metal binding site [ion binding]; metal-binding site 264732006185 xylulose binding site [chemical binding]; other site 264732006186 homodimer interface [polypeptide binding]; other site 264732006187 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264732006188 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 264732006189 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 264732006190 Subtilase family; Region: Peptidase_S8; pfam00082 264732006191 active site 264732006192 catalytic residues [active] 264732006193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264732006194 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264732006195 dimer interface [polypeptide binding]; other site 264732006196 putative CheW interface [polypeptide binding]; other site 264732006197 Cache domain; Region: Cache_1; pfam02743 264732006198 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 264732006199 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 264732006200 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 264732006201 metal binding site [ion binding]; metal-binding site 264732006202 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264732006203 substrate binding site [chemical binding]; other site 264732006204 glutamase interaction surface [polypeptide binding]; other site 264732006205 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 264732006206 catalytic residues [active] 264732006207 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264732006208 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 264732006209 putative active site [active] 264732006210 oxyanion strand; other site 264732006211 catalytic triad [active] 264732006212 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 264732006213 putative active site pocket [active] 264732006214 4-fold oligomerization interface [polypeptide binding]; other site 264732006215 metal binding residues [ion binding]; metal-binding site 264732006216 3-fold/trimer interface [polypeptide binding]; other site 264732006217 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264732006218 histidinol dehydrogenase; Region: hisD; TIGR00069 264732006219 NAD binding site [chemical binding]; other site 264732006220 dimerization interface [polypeptide binding]; other site 264732006221 product binding site; other site 264732006222 substrate binding site [chemical binding]; other site 264732006223 zinc binding site [ion binding]; other site 264732006224 catalytic residues [active] 264732006225 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 264732006226 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 264732006227 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 264732006228 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264732006229 dimer interface [polypeptide binding]; other site 264732006230 motif 1; other site 264732006231 active site 264732006232 motif 2; other site 264732006233 motif 3; other site 264732006234 Trp repressor protein; Region: Trp_repressor; cl17266 264732006235 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 264732006236 Spore germination protein; Region: Spore_permease; cl17796 264732006237 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 264732006238 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264732006239 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264732006240 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 264732006241 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264732006242 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264732006243 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264732006244 purine monophosphate binding site [chemical binding]; other site 264732006245 dimer interface [polypeptide binding]; other site 264732006246 putative catalytic residues [active] 264732006247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 264732006248 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264732006249 active site 264732006250 substrate binding site [chemical binding]; other site 264732006251 cosubstrate binding site; other site 264732006252 catalytic site [active] 264732006253 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264732006254 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264732006255 dimerization interface [polypeptide binding]; other site 264732006256 putative ATP binding site [chemical binding]; other site 264732006257 amidophosphoribosyltransferase; Provisional; Region: PRK05793 264732006258 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264732006259 active site 264732006260 tetramer interface [polypeptide binding]; other site 264732006261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732006262 active site 264732006263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 264732006264 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 264732006265 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264732006266 dimerization interface [polypeptide binding]; other site 264732006267 ATP binding site [chemical binding]; other site 264732006268 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264732006269 dimerization interface [polypeptide binding]; other site 264732006270 ATP binding site [chemical binding]; other site 264732006271 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264732006272 putative active site [active] 264732006273 catalytic triad [active] 264732006274 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 264732006275 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 264732006276 ATP binding site [chemical binding]; other site 264732006277 active site 264732006278 substrate binding site [chemical binding]; other site 264732006279 adenylosuccinate lyase; Provisional; Region: PRK07492 264732006280 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 264732006281 tetramer interface [polypeptide binding]; other site 264732006282 active site 264732006283 AIR carboxylase; Region: AIRC; pfam00731 264732006284 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 264732006285 oligomer interface [polypeptide binding]; other site 264732006286 active site 264732006287 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264732006288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732006289 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 264732006290 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264732006291 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264732006292 phosphate binding site [ion binding]; other site 264732006293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732006294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732006295 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 264732006296 Cobalt transport protein; Region: CbiQ; cl00463 264732006297 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 264732006298 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732006299 Walker A/P-loop; other site 264732006300 ATP binding site [chemical binding]; other site 264732006301 Q-loop/lid; other site 264732006302 ABC transporter signature motif; other site 264732006303 Walker B; other site 264732006304 D-loop; other site 264732006305 H-loop/switch region; other site 264732006306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732006307 Walker A/P-loop; other site 264732006308 ATP binding site [chemical binding]; other site 264732006309 Q-loop/lid; other site 264732006310 ABC transporter signature motif; other site 264732006311 Walker B; other site 264732006312 D-loop; other site 264732006313 H-loop/switch region; other site 264732006314 Protein of unknown function (DUF523); Region: DUF523; cl00733 264732006315 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 264732006316 putative active site [active] 264732006317 putative transposase OrfB; Reviewed; Region: PHA02517 264732006318 HTH-like domain; Region: HTH_21; pfam13276 264732006319 Integrase core domain; Region: rve; pfam00665 264732006320 Integrase core domain; Region: rve_3; pfam13683 264732006321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732006322 Transposase; Region: HTH_Tnp_1; cl17663 264732006323 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264732006324 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 264732006325 TrkA-C domain; Region: TrkA_C; pfam02080 264732006326 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 264732006327 nucleotide binding site [chemical binding]; other site 264732006328 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 264732006329 putative active site [active] 264732006330 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 264732006331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732006332 Walker A motif; other site 264732006333 ATP binding site [chemical binding]; other site 264732006334 Walker B motif; other site 264732006335 arginine finger; other site 264732006336 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732006337 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732006338 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 264732006339 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 264732006340 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732006341 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732006342 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732006343 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732006344 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 264732006345 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264732006346 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 264732006347 DNA binding residues [nucleotide binding] 264732006348 dimer interface [polypeptide binding]; other site 264732006349 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 264732006350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732006351 FeS/SAM binding site; other site 264732006352 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732006353 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264732006354 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264732006355 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 264732006356 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 264732006357 nucleotide binding site [chemical binding]; other site 264732006358 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732006359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732006360 dimerization interface [polypeptide binding]; other site 264732006361 putative DNA binding site [nucleotide binding]; other site 264732006362 putative Zn2+ binding site [ion binding]; other site 264732006363 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 264732006364 Predicted integral membrane protein [Function unknown]; Region: COG5658 264732006365 SdpI/YhfL protein family; Region: SdpI; pfam13630 264732006366 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 264732006367 active site 264732006368 catalytic triad [active] 264732006369 dimer interface [polypeptide binding]; other site 264732006370 intracellular protease, PfpI family; Region: PfpI; TIGR01382 264732006371 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 264732006372 conserved cys residue [active] 264732006373 S-layer homology domain; Region: SLH; pfam00395 264732006374 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 264732006375 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264732006376 Ferritin-like domain; Region: Ferritin; pfam00210 264732006377 dinuclear metal binding motif [ion binding]; other site 264732006378 Predicted transcriptional regulator [Transcription]; Region: COG1959 264732006379 Rrf2 family protein; Region: rrf2_super; TIGR00738 264732006380 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 264732006381 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 264732006382 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264732006383 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 264732006384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264732006385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732006386 Walker A/P-loop; other site 264732006387 ATP binding site [chemical binding]; other site 264732006388 Q-loop/lid; other site 264732006389 ABC transporter signature motif; other site 264732006390 Walker B; other site 264732006391 D-loop; other site 264732006392 H-loop/switch region; other site 264732006393 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 264732006394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264732006395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732006396 Walker A/P-loop; other site 264732006397 ATP binding site [chemical binding]; other site 264732006398 Q-loop/lid; other site 264732006399 ABC transporter signature motif; other site 264732006400 Walker B; other site 264732006401 D-loop; other site 264732006402 H-loop/switch region; other site 264732006403 Guanylate kinase; Region: Guanylate_kin; pfam00625 264732006404 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264732006405 catalytic site [active] 264732006406 G-X2-G-X-G-K; other site 264732006407 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 264732006408 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 264732006409 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264732006410 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 264732006411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732006412 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 264732006413 putative substrate translocation pore; other site 264732006414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732006415 NlpC/P60 family; Region: NLPC_P60; pfam00877 264732006416 GMP synthase; Reviewed; Region: guaA; PRK00074 264732006417 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264732006418 AMP/PPi binding site [chemical binding]; other site 264732006419 candidate oxyanion hole; other site 264732006420 catalytic triad [active] 264732006421 potential glutamine specificity residues [chemical binding]; other site 264732006422 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264732006423 ATP Binding subdomain [chemical binding]; other site 264732006424 Ligand Binding sites [chemical binding]; other site 264732006425 Dimerization subdomain; other site 264732006426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732006427 active site 264732006428 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264732006429 HSP70 interaction site [polypeptide binding]; other site 264732006430 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 264732006431 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264732006432 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264732006433 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 264732006434 homodimer interface [polypeptide binding]; other site 264732006435 substrate-cofactor binding pocket; other site 264732006436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006437 catalytic residue [active] 264732006438 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264732006439 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 264732006440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732006441 catalytic loop [active] 264732006442 iron binding site [ion binding]; other site 264732006443 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 264732006444 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 264732006445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732006446 active site 264732006447 phosphorylation site [posttranslational modification] 264732006448 intermolecular recognition site; other site 264732006449 dimerization interface [polypeptide binding]; other site 264732006450 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 264732006451 nucleotidyl binding site; other site 264732006452 metal binding site [ion binding]; metal-binding site 264732006453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264732006454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264732006455 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732006456 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 264732006457 B12 binding site [chemical binding]; other site 264732006458 cobalt ligand [ion binding]; other site 264732006459 Sensory domain found in PocR; Region: PocR; pfam10114 264732006460 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 264732006461 Histidine kinase; Region: His_kinase; pfam06580 264732006462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732006463 ATP binding site [chemical binding]; other site 264732006464 Mg2+ binding site [ion binding]; other site 264732006465 G-X-G motif; other site 264732006466 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 264732006467 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264732006468 substrate binding pocket [chemical binding]; other site 264732006469 dimer interface [polypeptide binding]; other site 264732006470 inhibitor binding site; inhibition site 264732006471 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 264732006472 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 264732006473 B12 binding site [chemical binding]; other site 264732006474 cobalt ligand [ion binding]; other site 264732006475 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 264732006476 putative substrate binding site [chemical binding]; other site 264732006477 nucleotide binding site [chemical binding]; other site 264732006478 nucleotide binding site [chemical binding]; other site 264732006479 homodimer interface [polypeptide binding]; other site 264732006480 Sulfate transporter family; Region: Sulfate_transp; cl19250 264732006481 xanthine permease; Region: pbuX; TIGR03173 264732006482 Protein of unknown function, DUF606; Region: DUF606; pfam04657 264732006483 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 264732006484 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 264732006485 membrane protein FdrA; Validated; Region: PRK06091 264732006486 CoA binding domain; Region: CoA_binding; pfam02629 264732006487 CoA-ligase; Region: Ligase_CoA; pfam00549 264732006488 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 264732006489 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 264732006490 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 264732006491 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264732006492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732006493 active site 264732006494 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 264732006495 heterodimer interface [polypeptide binding]; other site 264732006496 active site 264732006497 FMN binding site [chemical binding]; other site 264732006498 homodimer interface [polypeptide binding]; other site 264732006499 substrate binding site [chemical binding]; other site 264732006500 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 264732006501 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 264732006502 FAD binding pocket [chemical binding]; other site 264732006503 FAD binding motif [chemical binding]; other site 264732006504 phosphate binding motif [ion binding]; other site 264732006505 beta-alpha-beta structure motif; other site 264732006506 NAD binding pocket [chemical binding]; other site 264732006507 Iron coordination center [ion binding]; other site 264732006508 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 264732006509 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264732006510 ring oligomerisation interface [polypeptide binding]; other site 264732006511 ATP/Mg binding site [chemical binding]; other site 264732006512 stacking interactions; other site 264732006513 hinge regions; other site 264732006514 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264732006515 oligomerisation interface [polypeptide binding]; other site 264732006516 mobile loop; other site 264732006517 roof hairpin; other site 264732006518 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732006519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732006520 Zn2+ binding site [ion binding]; other site 264732006521 Mg2+ binding site [ion binding]; other site 264732006522 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 264732006523 MPT binding site; other site 264732006524 trimer interface [polypeptide binding]; other site 264732006525 MOSC domain; Region: MOSC; pfam03473 264732006526 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 264732006527 trimer interface [polypeptide binding]; other site 264732006528 dimer interface [polypeptide binding]; other site 264732006529 putative active site [active] 264732006530 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 264732006531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732006532 FeS/SAM binding site; other site 264732006533 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 264732006534 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264732006535 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264732006536 dimer interface [polypeptide binding]; other site 264732006537 putative functional site; other site 264732006538 putative MPT binding site; other site 264732006539 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264732006540 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264732006541 dimer interface [polypeptide binding]; other site 264732006542 putative functional site; other site 264732006543 putative MPT binding site; other site 264732006544 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 264732006545 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 264732006546 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 264732006547 Helix-turn-helix domain; Region: HTH_17; pfam12728 264732006548 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 264732006549 S-layer homology domain; Region: SLH; pfam00395 264732006550 S-layer homology domain; Region: SLH; pfam00395 264732006551 S-layer homology domain; Region: SLH; pfam00395 264732006552 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 264732006553 PAS domain S-box; Region: sensory_box; TIGR00229 264732006554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732006555 putative active site [active] 264732006556 heme pocket [chemical binding]; other site 264732006557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732006558 PAS domain; Region: PAS_9; pfam13426 264732006559 putative active site [active] 264732006560 heme pocket [chemical binding]; other site 264732006561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732006562 metal binding site [ion binding]; metal-binding site 264732006563 active site 264732006564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732006565 metal binding site [ion binding]; metal-binding site 264732006566 active site 264732006567 I-site; other site 264732006568 Sensory domain found in PocR; Region: PocR; pfam10114 264732006569 GAF domain; Region: GAF_3; pfam13492 264732006570 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 264732006571 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732006572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732006573 Zn2+ binding site [ion binding]; other site 264732006574 Mg2+ binding site [ion binding]; other site 264732006575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264732006576 metal binding site [ion binding]; metal-binding site 264732006577 active site 264732006578 I-site; other site 264732006579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264732006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732006581 active site 264732006582 phosphorylation site [posttranslational modification] 264732006583 intermolecular recognition site; other site 264732006584 dimerization interface [polypeptide binding]; other site 264732006585 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 264732006586 metal binding site [ion binding]; metal-binding site 264732006587 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 264732006588 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 264732006589 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 264732006590 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 264732006591 DXD motif; other site 264732006592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264732006593 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264732006594 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 264732006595 Transposase domain (DUF772); Region: DUF772; pfam05598 264732006596 UGMP family protein; Validated; Region: PRK09604 264732006597 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 264732006598 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264732006599 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 264732006600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264732006601 Coenzyme A binding pocket [chemical binding]; other site 264732006602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264732006603 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264732006604 Glycoprotease family; Region: Peptidase_M22; pfam00814 264732006605 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 264732006606 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 264732006607 Fe-S cluster binding site [ion binding]; other site 264732006608 active site 264732006609 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264732006610 thiamine phosphate binding site [chemical binding]; other site 264732006611 active site 264732006612 pyrophosphate binding site [ion binding]; other site 264732006613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732006614 active site 264732006615 phosphorylation site [posttranslational modification] 264732006616 intermolecular recognition site; other site 264732006617 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 264732006618 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264732006619 catalytic triad [active] 264732006620 PemK-like protein; Region: PemK; pfam02452 264732006621 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 264732006622 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 264732006623 alanine racemase; Reviewed; Region: alr; PRK00053 264732006624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264732006625 active site 264732006626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264732006627 dimer interface [polypeptide binding]; other site 264732006628 substrate binding site [chemical binding]; other site 264732006629 catalytic residues [active] 264732006630 putative carbohydrate kinase; Provisional; Region: PRK10565 264732006631 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 264732006632 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264732006633 putative substrate binding site [chemical binding]; other site 264732006634 putative ATP binding site [chemical binding]; other site 264732006635 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 264732006636 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264732006637 acyl-activating enzyme (AAE) consensus motif; other site 264732006638 GAF domain; Region: GAF; pfam01590 264732006639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264732006640 Histidine kinase; Region: His_kinase; pfam06580 264732006641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732006642 ATP binding site [chemical binding]; other site 264732006643 Mg2+ binding site [ion binding]; other site 264732006644 G-X-G motif; other site 264732006645 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264732006646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732006647 active site 264732006648 phosphorylation site [posttranslational modification] 264732006649 intermolecular recognition site; other site 264732006650 dimerization interface [polypeptide binding]; other site 264732006651 LytTr DNA-binding domain; Region: LytTR; smart00850 264732006652 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 264732006653 GTP binding site; other site 264732006654 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 264732006655 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 264732006656 dimerization interface [polypeptide binding]; other site 264732006657 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 264732006658 ATP binding site [chemical binding]; other site 264732006659 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 264732006660 HupF/HypC family; Region: HupF_HypC; pfam01455 264732006661 Acylphosphatase; Region: Acylphosphatase; pfam00708 264732006662 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 264732006663 HypF finger; Region: zf-HYPF; pfam07503 264732006664 HypF finger; Region: zf-HYPF; pfam07503 264732006665 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 264732006666 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732006667 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 264732006668 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 264732006669 nickel binding site [ion binding]; other site 264732006670 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 264732006671 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 264732006672 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 264732006673 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732006674 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 264732006675 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 264732006676 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 264732006677 hydrogenase 4 subunit D; Validated; Region: PRK06525 264732006678 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732006679 hydrogenase 4 subunit F; Validated; Region: PRK06458 264732006680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732006681 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 264732006682 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 264732006683 hydrogenase 4 subunit B; Validated; Region: PRK06521 264732006684 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264732006685 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 264732006686 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732006687 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 264732006688 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264732006689 [4Fe-4S] binding site [ion binding]; other site 264732006690 molybdopterin cofactor binding site; other site 264732006691 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 264732006692 molybdopterin cofactor binding site; other site 264732006693 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 264732006694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732006695 dimerization interface [polypeptide binding]; other site 264732006696 putative DNA binding site [nucleotide binding]; other site 264732006697 putative Zn2+ binding site [ion binding]; other site 264732006698 Predicted permeases [General function prediction only]; Region: COG0701 264732006699 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264732006700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732006701 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264732006702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732006703 ResB-like family; Region: ResB; pfam05140 264732006704 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 264732006705 YKOF-related Family; Region: Ykof; pfam07615 264732006706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732006707 dimerization interface [polypeptide binding]; other site 264732006708 putative DNA binding site [nucleotide binding]; other site 264732006709 putative Zn2+ binding site [ion binding]; other site 264732006710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264732006711 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264732006712 metal-binding site [ion binding] 264732006713 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264732006714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264732006715 active site 264732006716 motif I; other site 264732006717 motif II; other site 264732006718 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 264732006719 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264732006720 active site 264732006721 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264732006722 active site 2 [active] 264732006723 active site 1 [active] 264732006724 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 264732006725 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 264732006726 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 264732006727 putative active site [active] 264732006728 arsenical-resistance protein; Region: acr3; TIGR00832 264732006729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264732006730 dimerization interface [polypeptide binding]; other site 264732006731 putative DNA binding site [nucleotide binding]; other site 264732006732 putative Zn2+ binding site [ion binding]; other site 264732006733 Transcriptional regulator PadR-like family; Region: PadR; cl17335 264732006734 Predicted permease; Region: DUF318; cl17795 264732006735 Putative Fe-S cluster; Region: FeS; cl17515 264732006736 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264732006737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732006738 catalytic residue [active] 264732006739 DGC domain; Region: DGC; pfam08859 264732006740 DGC domain; Region: DGC; pfam08859 264732006741 DGC domain; Region: DGC; pfam08859 264732006742 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264732006743 lipoyl attachment site [posttranslational modification]; other site 264732006744 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 264732006745 Ferredoxin [Energy production and conversion]; Region: COG1146 264732006746 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 264732006747 Predicted transcriptional regulators [Transcription]; Region: COG1695 264732006748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732006749 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 264732006750 Bacterial SH3 domain; Region: SH3_3; pfam08239 264732006751 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264732006752 NlpC/P60 family; Region: NLPC_P60; pfam00877 264732006753 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 264732006754 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 264732006755 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 264732006756 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264732006757 Ligand binding site; other site 264732006758 Putative Catalytic site; other site 264732006759 DXD motif; other site 264732006760 putative transposase OrfB; Reviewed; Region: PHA02517 264732006761 HTH-like domain; Region: HTH_21; pfam13276 264732006762 Integrase core domain; Region: rve; pfam00665 264732006763 Integrase core domain; Region: rve_3; pfam13683 264732006764 Transposase; Region: HTH_Tnp_1; cl17663 264732006765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264732006766 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 264732006767 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264732006768 putative active site [active] 264732006769 putative NTP binding site [chemical binding]; other site 264732006770 putative nucleic acid binding site [nucleotide binding]; other site 264732006771 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 264732006772 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 264732006773 active site 264732006774 NTP binding site [chemical binding]; other site 264732006775 metal binding triad [ion binding]; metal-binding site 264732006776 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264732006777 Ligand Binding Site [chemical binding]; other site 264732006778 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 264732006779 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 264732006780 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264732006781 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 264732006782 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 264732006783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 264732006784 DNA-binding interface [nucleotide binding]; DNA binding site 264732006785 Integrase core domain; Region: rve; pfam00665 264732006786 Integrase core domain; Region: rve_3; cl15866 264732006787 transposase; Provisional; Region: PRK06526 264732006788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732006789 Walker A motif; other site 264732006790 ATP binding site [chemical binding]; other site 264732006791 Walker B motif; other site 264732006792 arginine finger; other site 264732006793 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264732006794 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264732006795 AAA ATPase domain; Region: AAA_16; pfam13191 264732006796 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264732006797 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264732006798 glutaminase active site [active] 264732006799 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264732006800 dimer interface [polypeptide binding]; other site 264732006801 active site 264732006802 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264732006803 dimer interface [polypeptide binding]; other site 264732006804 active site 264732006805 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 264732006806 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264732006807 active site 264732006808 substrate binding site [chemical binding]; other site 264732006809 metal binding site [ion binding]; metal-binding site 264732006810 YbbR-like protein; Region: YbbR; pfam07949 264732006811 YbbR-like protein; Region: YbbR; pfam07949 264732006812 YbbR-like protein; Region: YbbR; pfam07949 264732006813 Uncharacterized conserved protein [Function unknown]; Region: COG1624 264732006814 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 264732006815 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 264732006816 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 264732006817 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 264732006818 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 264732006819 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 264732006820 active site 264732006821 catalytic residues [active] 264732006822 metal binding site [ion binding]; metal-binding site 264732006823 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 264732006824 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 264732006825 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 264732006826 substrate binding site [chemical binding]; other site 264732006827 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264732006828 substrate binding site [chemical binding]; other site 264732006829 ligand binding site [chemical binding]; other site 264732006830 2-isopropylmalate synthase; Validated; Region: PRK00915 264732006831 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 264732006832 active site 264732006833 catalytic residues [active] 264732006834 metal binding site [ion binding]; metal-binding site 264732006835 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 264732006836 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 264732006837 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264732006838 PYR/PP interface [polypeptide binding]; other site 264732006839 dimer interface [polypeptide binding]; other site 264732006840 TPP binding site [chemical binding]; other site 264732006841 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264732006842 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264732006843 TPP-binding site [chemical binding]; other site 264732006844 dimer interface [polypeptide binding]; other site 264732006845 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264732006846 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264732006847 putative valine binding site [chemical binding]; other site 264732006848 dimer interface [polypeptide binding]; other site 264732006849 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264732006850 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 264732006851 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264732006852 PYR/PP interface [polypeptide binding]; other site 264732006853 dimer interface [polypeptide binding]; other site 264732006854 TPP binding site [chemical binding]; other site 264732006855 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264732006856 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264732006857 TPP-binding site [chemical binding]; other site 264732006858 dimer interface [polypeptide binding]; other site 264732006859 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 264732006860 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 264732006861 homodimer interface [polypeptide binding]; other site 264732006862 substrate-cofactor binding pocket; other site 264732006863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006864 catalytic residue [active] 264732006865 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 264732006866 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 264732006867 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732006868 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732006869 Zn2+ binding site [ion binding]; other site 264732006870 Mg2+ binding site [ion binding]; other site 264732006871 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264732006872 active site 1 [active] 264732006873 dimer interface [polypeptide binding]; other site 264732006874 hexamer interface [polypeptide binding]; other site 264732006875 active site 2 [active] 264732006876 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 264732006877 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 264732006878 homodimer interface [polypeptide binding]; other site 264732006879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006880 catalytic residue [active] 264732006881 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 264732006882 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 264732006883 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264732006884 anion transporter; Region: dass; TIGR00785 264732006885 transmembrane helices; other site 264732006886 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264732006887 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264732006888 NAD(P) binding site [chemical binding]; other site 264732006889 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 264732006890 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 264732006891 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264732006892 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 264732006893 intersubunit interface [polypeptide binding]; other site 264732006894 active site 264732006895 Zn2+ binding site [ion binding]; other site 264732006896 Creatinine amidohydrolase; Region: Creatininase; pfam02633 264732006897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264732006898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264732006899 DNA binding site [nucleotide binding] 264732006900 domain linker motif; other site 264732006901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264732006902 dimerization interface [polypeptide binding]; other site 264732006903 ligand binding site [chemical binding]; other site 264732006904 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264732006905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732006906 DNA-binding site [nucleotide binding]; DNA binding site 264732006907 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264732006908 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264732006909 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 264732006910 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264732006911 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 264732006912 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 264732006913 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 264732006914 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264732006915 dimer interface [polypeptide binding]; other site 264732006916 PYR/PP interface [polypeptide binding]; other site 264732006917 TPP binding site [chemical binding]; other site 264732006918 substrate binding site [chemical binding]; other site 264732006919 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264732006920 TPP-binding site; other site 264732006921 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264732006922 4Fe-4S binding domain; Region: Fer4; pfam00037 264732006923 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264732006924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264732006925 acyl-activating enzyme (AAE) consensus motif; other site 264732006926 AMP binding site [chemical binding]; other site 264732006927 active site 264732006928 CoA binding site [chemical binding]; other site 264732006929 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264732006930 Na binding site [ion binding]; other site 264732006931 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 264732006932 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264732006933 Double zinc ribbon; Region: DZR; pfam12773 264732006934 Fumarase C-terminus; Region: Fumerase_C; pfam05683 264732006935 fumarate hydratase; Provisional; Region: PRK06246 264732006936 argininosuccinate lyase; Provisional; Region: PRK00855 264732006937 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264732006938 active sites [active] 264732006939 tetramer interface [polypeptide binding]; other site 264732006940 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 264732006941 ANP binding site [chemical binding]; other site 264732006942 Substrate Binding Site II [chemical binding]; other site 264732006943 Substrate Binding Site I [chemical binding]; other site 264732006944 ornithine carbamoyltransferase; Provisional; Region: PRK00779 264732006945 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264732006946 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264732006947 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264732006948 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 264732006949 inhibitor-cofactor binding pocket; inhibition site 264732006950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264732006951 catalytic residue [active] 264732006952 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 264732006953 feedback inhibition sensing region; other site 264732006954 homohexameric interface [polypeptide binding]; other site 264732006955 nucleotide binding site [chemical binding]; other site 264732006956 N-acetyl-L-glutamate binding site [chemical binding]; other site 264732006957 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 264732006958 heterotetramer interface [polypeptide binding]; other site 264732006959 active site pocket [active] 264732006960 cleavage site 264732006961 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 264732006962 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 264732006963 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 264732006964 Src Homology 3 domain superfamily; Region: SH3; cl17036 264732006965 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 264732006966 amidohydrolase; Region: amidohydrolases; TIGR01891 264732006967 metal binding site [ion binding]; metal-binding site 264732006968 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 264732006969 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 264732006970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732006971 FeS/SAM binding site; other site 264732006972 hypothetical protein; Provisional; Region: PRK03881 264732006973 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 264732006974 AMMECR1; Region: AMMECR1; pfam01871 264732006975 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264732006976 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264732006977 active site 264732006978 metal binding site [ion binding]; metal-binding site 264732006979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732006980 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 264732006981 Walker A/P-loop; other site 264732006982 ATP binding site [chemical binding]; other site 264732006983 Q-loop/lid; other site 264732006984 ABC transporter signature motif; other site 264732006985 Walker B; other site 264732006986 D-loop; other site 264732006987 H-loop/switch region; other site 264732006988 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 264732006989 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264732006990 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264732006991 glutamine synthetase, type I; Region: GlnA; TIGR00653 264732006992 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264732006993 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264732006994 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 264732006995 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 264732006996 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 264732006997 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 264732006998 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264732006999 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264732007000 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264732007001 L-lactate permease; Region: Lactate_perm; cl00701 264732007002 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264732007003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264732007004 DNA-binding site [nucleotide binding]; DNA binding site 264732007005 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264732007006 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264732007007 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264732007008 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732007009 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732007010 Cysteine-rich domain; Region: CCG; pfam02754 264732007011 Cysteine-rich domain; Region: CCG; pfam02754 264732007012 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264732007013 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264732007014 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732007015 Cysteine-rich domain; Region: CCG; pfam02754 264732007016 Cysteine-rich domain; Region: CCG; pfam02754 264732007017 FAD binding domain; Region: FAD_binding_4; pfam01565 264732007018 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 264732007019 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 264732007020 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264732007021 GDP-binding site [chemical binding]; other site 264732007022 ACT binding site; other site 264732007023 IMP binding site; other site 264732007024 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264732007025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264732007026 EamA-like transporter family; Region: EamA; pfam00892 264732007027 EamA-like transporter family; Region: EamA; pfam00892 264732007028 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 264732007029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264732007030 catalytic loop [active] 264732007031 iron binding site [ion binding]; other site 264732007032 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264732007033 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264732007034 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264732007035 [4Fe-4S] binding site [ion binding]; other site 264732007036 molybdopterin cofactor binding site; other site 264732007037 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 264732007038 molybdopterin cofactor binding site; other site 264732007039 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264732007040 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 264732007041 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 264732007042 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264732007043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732007044 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 264732007045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732007046 Protein of unknown function DUF86; Region: DUF86; pfam01934 264732007047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264732007048 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264732007049 Walker A motif; other site 264732007050 ATP binding site [chemical binding]; other site 264732007051 Walker B motif; other site 264732007052 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732007053 active site 264732007054 NTP binding site [chemical binding]; other site 264732007055 metal binding triad [ion binding]; metal-binding site 264732007056 antibiotic binding site [chemical binding]; other site 264732007057 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264732007058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732007059 Outer membrane efflux protein; Region: OEP; pfam02321 264732007060 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732007061 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 264732007062 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264732007063 lipoyl-biotinyl attachment site [posttranslational modification]; other site 264732007064 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732007065 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264732007066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732007067 putative substrate translocation pore; other site 264732007068 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264732007069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264732007070 putative DNA binding site [nucleotide binding]; other site 264732007071 putative Zn2+ binding site [ion binding]; other site 264732007072 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 264732007073 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 264732007074 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 264732007075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264732007076 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732007077 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732007078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264732007079 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 264732007080 Walker A/P-loop; other site 264732007081 ATP binding site [chemical binding]; other site 264732007082 Q-loop/lid; other site 264732007083 ABC transporter signature motif; other site 264732007084 Walker B; other site 264732007085 D-loop; other site 264732007086 H-loop/switch region; other site 264732007087 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 264732007088 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 264732007089 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264732007090 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 264732007091 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264732007092 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264732007093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264732007094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264732007095 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 264732007096 Transcriptional regulator, TetR, C-terminal; Region: TetR_C_9; pfam14514 264732007097 PIN domain; Region: PIN_3; cl17397 264732007098 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264732007099 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 264732007100 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 264732007101 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 264732007102 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264732007103 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264732007104 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264732007105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264732007106 Transposase; Region: HTH_Tnp_1; cl17663 264732007107 S-layer homology domain; Region: SLH; pfam00395 264732007108 S-layer homology domain; Region: SLH; pfam00395 264732007109 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264732007110 Outer membrane efflux protein; Region: OEP; pfam02321 264732007111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732007112 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732007113 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732007114 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 264732007115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732007116 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 264732007117 putative substrate translocation pore; other site 264732007118 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 264732007119 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 264732007120 Predicted transcriptional regulators [Transcription]; Region: COG1695 264732007121 putative DNA binding site [nucleotide binding]; other site 264732007122 Predicted membrane protein [Function unknown]; Region: COG4709 264732007123 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 264732007124 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 264732007125 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264732007126 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 264732007127 active site 264732007128 NTP binding site [chemical binding]; other site 264732007129 metal binding triad [ion binding]; metal-binding site 264732007130 antibiotic binding site [chemical binding]; other site 264732007131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264732007132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264732007133 FtsX-like permease family; Region: FtsX; pfam02687 264732007134 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264732007135 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264732007136 Walker A/P-loop; other site 264732007137 ATP binding site [chemical binding]; other site 264732007138 Q-loop/lid; other site 264732007139 ABC transporter signature motif; other site 264732007140 Walker B; other site 264732007141 D-loop; other site 264732007142 H-loop/switch region; other site 264732007143 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 264732007144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264732007145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732007146 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732007147 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264732007148 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264732007149 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264732007150 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264732007151 Ligand binding site; other site 264732007152 Putative Catalytic site; other site 264732007153 DXD motif; other site 264732007154 GtrA-like protein; Region: GtrA; pfam04138 264732007155 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 264732007156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732007157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264732007158 DNA binding residues [nucleotide binding] 264732007159 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 264732007160 Putative zinc-finger; Region: zf-HC2; pfam13490 264732007161 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 264732007162 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 264732007163 Subtilase family; Region: Peptidase_S8; pfam00082 264732007164 active site 264732007165 catalytic triad [active] 264732007166 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 264732007167 S-layer homology domain; Region: SLH; pfam00395 264732007168 S-layer homology domain; Region: SLH; pfam00395 264732007169 S-layer homology domain; Region: SLH; pfam00395 264732007170 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 264732007171 Transcriptional regulator [Transcription]; Region: LytR; COG1316 264732007172 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 264732007173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264732007174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264732007175 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264732007176 MMPL family; Region: MMPL; cl14618 264732007177 MMPL family; Region: MMPL; cl14618 264732007178 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264732007179 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264732007180 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 264732007181 HlyD family secretion protein; Region: HlyD_3; pfam13437 264732007182 rod shape-determining protein Mbl; Provisional; Region: PRK13928 264732007183 MreB and similar proteins; Region: MreB_like; cd10225 264732007184 nucleotide binding site [chemical binding]; other site 264732007185 Mg binding site [ion binding]; other site 264732007186 putative protofilament interaction site [polypeptide binding]; other site 264732007187 RodZ interaction site [polypeptide binding]; other site 264732007188 Stage III sporulation protein D; Region: SpoIIID; pfam12116 264732007189 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732007190 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732007191 stage II sporulation protein D; Region: spore_II_D; TIGR02870 264732007192 Stage II sporulation protein; Region: SpoIID; pfam08486 264732007193 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 264732007194 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264732007195 hinge; other site 264732007196 active site 264732007197 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 264732007198 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264732007199 gamma subunit interface [polypeptide binding]; other site 264732007200 epsilon subunit interface [polypeptide binding]; other site 264732007201 LBP interface [polypeptide binding]; other site 264732007202 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264732007203 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264732007204 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264732007205 alpha subunit interaction interface [polypeptide binding]; other site 264732007206 Walker A motif; other site 264732007207 ATP binding site [chemical binding]; other site 264732007208 Walker B motif; other site 264732007209 inhibitor binding site; inhibition site 264732007210 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264732007211 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264732007212 core domain interface [polypeptide binding]; other site 264732007213 delta subunit interface [polypeptide binding]; other site 264732007214 epsilon subunit interface [polypeptide binding]; other site 264732007215 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264732007216 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264732007217 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264732007218 beta subunit interaction interface [polypeptide binding]; other site 264732007219 Walker A motif; other site 264732007220 ATP binding site [chemical binding]; other site 264732007221 Walker B motif; other site 264732007222 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264732007223 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264732007224 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 264732007225 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 264732007226 ATP synthase subunit C; Region: ATP-synt_C; cl00466 264732007227 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 264732007228 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 264732007229 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 264732007230 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264732007231 active site 264732007232 homodimer interface [polypeptide binding]; other site 264732007233 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 264732007234 homodimer interface [polypeptide binding]; other site 264732007235 metal binding site [ion binding]; metal-binding site 264732007236 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 264732007237 catalytic motif [active] 264732007238 Zn binding site [ion binding]; other site 264732007239 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264732007240 dimer interface [polypeptide binding]; other site 264732007241 active site 264732007242 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264732007243 folate binding site [chemical binding]; other site 264732007244 hypothetical protein; Provisional; Region: PRK13690 264732007245 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 264732007246 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264732007247 active site 264732007248 Predicted membrane protein [Function unknown]; Region: COG1971 264732007249 Domain of unknown function DUF; Region: DUF204; pfam02659 264732007250 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 264732007251 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 264732007252 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264732007253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264732007254 S-adenosylmethionine binding site [chemical binding]; other site 264732007255 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264732007256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732007257 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264732007258 RF-1 domain; Region: RF-1; pfam00472 264732007259 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 264732007260 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 264732007261 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264732007262 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732007263 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732007264 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732007265 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264732007266 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 264732007267 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264732007268 RNA binding site [nucleotide binding]; other site 264732007269 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264732007270 multimer interface [polypeptide binding]; other site 264732007271 Walker A motif; other site 264732007272 ATP binding site [chemical binding]; other site 264732007273 Walker B motif; other site 264732007274 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 264732007275 active site 264732007276 intersubunit interactions; other site 264732007277 catalytic residue [active] 264732007278 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264732007279 intersubunit interface [polypeptide binding]; other site 264732007280 active site 264732007281 zinc binding site [ion binding]; other site 264732007282 Na+ binding site [ion binding]; other site 264732007283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264732007284 active site 264732007285 phosphorylation site [posttranslational modification] 264732007286 intermolecular recognition site; other site 264732007287 dimerization interface [polypeptide binding]; other site 264732007288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264732007289 alanine racemase; Reviewed; Region: alr; PRK00053 264732007290 active site 264732007291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264732007292 dimer interface [polypeptide binding]; other site 264732007293 substrate binding site [chemical binding]; other site 264732007294 catalytic residues [active] 264732007295 FemAB family; Region: FemAB; pfam02388 264732007296 CTP synthetase; Validated; Region: pyrG; PRK05380 264732007297 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264732007298 Catalytic site [active] 264732007299 active site 264732007300 UTP binding site [chemical binding]; other site 264732007301 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264732007302 active site 264732007303 putative oxyanion hole; other site 264732007304 catalytic triad [active] 264732007305 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 264732007306 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 264732007307 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264732007308 active site 264732007309 HIGH motif; other site 264732007310 KMSK motif region; other site 264732007311 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 264732007312 tRNA binding surface [nucleotide binding]; other site 264732007313 anticodon binding site; other site 264732007314 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 264732007315 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 264732007316 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 264732007317 benzoate transport; Region: 2A0115; TIGR00895 264732007318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264732007319 putative substrate translocation pore; other site 264732007320 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 264732007321 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264732007322 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 264732007323 DHH family; Region: DHH; pfam01368 264732007324 DHHA2 domain; Region: DHHA2; pfam02833 264732007325 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 264732007326 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264732007327 active site 264732007328 ATP binding site [chemical binding]; other site 264732007329 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264732007330 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 264732007331 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264732007332 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264732007333 protein binding site [polypeptide binding]; other site 264732007334 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 264732007335 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264732007336 metal-binding site [ion binding] 264732007337 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264732007338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 264732007339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264732007340 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 264732007341 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 264732007342 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264732007343 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264732007344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264732007345 G5 domain; Region: G5; pfam07501 264732007346 Peptidase family M23; Region: Peptidase_M23; pfam01551 264732007347 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 264732007348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264732007349 FeS/SAM binding site; other site 264732007350 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264732007351 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264732007352 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264732007353 23S rRNA interface [nucleotide binding]; other site 264732007354 L3 interface [polypeptide binding]; other site 264732007355 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264732007356 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264732007357 dimerization interface 3.5A [polypeptide binding]; other site 264732007358 active site 264732007359 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 264732007360 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732007361 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 264732007362 Walker A/P-loop; other site 264732007363 ATP binding site [chemical binding]; other site 264732007364 Q-loop/lid; other site 264732007365 ABC transporter signature motif; other site 264732007366 Walker B; other site 264732007367 D-loop; other site 264732007368 H-loop/switch region; other site 264732007369 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 264732007370 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264732007371 Walker A/P-loop; other site 264732007372 ATP binding site [chemical binding]; other site 264732007373 Q-loop/lid; other site 264732007374 ABC transporter signature motif; other site 264732007375 Walker B; other site 264732007376 D-loop; other site 264732007377 H-loop/switch region; other site 264732007378 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264732007379 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264732007380 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264732007381 alphaNTD homodimer interface [polypeptide binding]; other site 264732007382 alphaNTD - beta interaction site [polypeptide binding]; other site 264732007383 alphaNTD - beta' interaction site [polypeptide binding]; other site 264732007384 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264732007385 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264732007386 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264732007387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264732007388 RNA binding surface [nucleotide binding]; other site 264732007389 30S ribosomal protein S11; Validated; Region: PRK05309 264732007390 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264732007391 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 264732007392 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264732007393 rRNA binding site [nucleotide binding]; other site 264732007394 predicted 30S ribosome binding site; other site 264732007395 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 264732007396 RNA binding site [nucleotide binding]; other site 264732007397 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264732007398 active site 264732007399 adenylate kinase; Reviewed; Region: adk; PRK00279 264732007400 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264732007401 AMP-binding site [chemical binding]; other site 264732007402 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264732007403 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264732007404 SecY translocase; Region: SecY; pfam00344 264732007405 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264732007406 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264732007407 23S rRNA binding site [nucleotide binding]; other site 264732007408 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264732007409 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264732007410 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264732007411 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264732007412 5S rRNA interface [nucleotide binding]; other site 264732007413 L27 interface [polypeptide binding]; other site 264732007414 23S rRNA interface [nucleotide binding]; other site 264732007415 L5 interface [polypeptide binding]; other site 264732007416 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264732007417 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264732007418 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264732007419 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264732007420 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 264732007421 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264732007422 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264732007423 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264732007424 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264732007425 RNA binding site [nucleotide binding]; other site 264732007426 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264732007427 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264732007428 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264732007429 23S rRNA interface [nucleotide binding]; other site 264732007430 putative translocon interaction site; other site 264732007431 signal recognition particle (SRP54) interaction site; other site 264732007432 L23 interface [polypeptide binding]; other site 264732007433 trigger factor interaction site; other site 264732007434 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264732007435 23S rRNA interface [nucleotide binding]; other site 264732007436 5S rRNA interface [nucleotide binding]; other site 264732007437 putative antibiotic binding site [chemical binding]; other site 264732007438 L25 interface [polypeptide binding]; other site 264732007439 L27 interface [polypeptide binding]; other site 264732007440 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264732007441 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264732007442 G-X-X-G motif; other site 264732007443 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264732007444 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264732007445 putative translocon binding site; other site 264732007446 protein-rRNA interface [nucleotide binding]; other site 264732007447 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264732007448 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264732007449 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264732007450 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264732007451 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264732007452 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264732007453 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 264732007454 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264732007455 elongation factor Tu; Reviewed; Region: PRK00049 264732007456 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264732007457 G1 box; other site 264732007458 GEF interaction site [polypeptide binding]; other site 264732007459 GTP/Mg2+ binding site [chemical binding]; other site 264732007460 Switch I region; other site 264732007461 G2 box; other site 264732007462 G3 box; other site 264732007463 Switch II region; other site 264732007464 G4 box; other site 264732007465 G5 box; other site 264732007466 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264732007467 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264732007468 Antibiotic Binding Site [chemical binding]; other site 264732007469 elongation factor G; Reviewed; Region: PRK00007 264732007470 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264732007471 G1 box; other site 264732007472 putative GEF interaction site [polypeptide binding]; other site 264732007473 GTP/Mg2+ binding site [chemical binding]; other site 264732007474 Switch I region; other site 264732007475 G2 box; other site 264732007476 G3 box; other site 264732007477 Switch II region; other site 264732007478 G4 box; other site 264732007479 G5 box; other site 264732007480 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264732007481 Elongation Factor G, domain II; Region: EFG_II; pfam14492 264732007482 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264732007483 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264732007484 30S ribosomal protein S7; Validated; Region: PRK05302 264732007485 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264732007486 S17 interaction site [polypeptide binding]; other site 264732007487 S8 interaction site; other site 264732007488 16S rRNA interaction site [nucleotide binding]; other site 264732007489 streptomycin interaction site [chemical binding]; other site 264732007490 23S rRNA interaction site [nucleotide binding]; other site 264732007491 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264732007492 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 264732007493 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 264732007494 beta and beta' interface [polypeptide binding]; other site 264732007495 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 264732007496 beta' and sigma factor interface [polypeptide binding]; other site 264732007497 Zn-binding [ion binding]; other site 264732007498 active site region [active] 264732007499 catalytic site [active] 264732007500 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264732007501 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 264732007502 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264732007503 G-loop; other site 264732007504 DNA binding site [nucleotide binding] 264732007505 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 264732007506 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 264732007507 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264732007508 RPB12 interaction site [polypeptide binding]; other site 264732007509 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 264732007510 RPB1 interaction site [polypeptide binding]; other site 264732007511 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 264732007512 RPB10 interaction site [polypeptide binding]; other site 264732007513 RPB11 interaction site [polypeptide binding]; other site 264732007514 RPB3 interaction site [polypeptide binding]; other site 264732007515 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264732007516 peripheral dimer interface [polypeptide binding]; other site 264732007517 core dimer interface [polypeptide binding]; other site 264732007518 L10 interface [polypeptide binding]; other site 264732007519 L11 interface [polypeptide binding]; other site 264732007520 putative EF-Tu interaction site [polypeptide binding]; other site 264732007521 putative EF-G interaction site [polypeptide binding]; other site 264732007522 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264732007523 23S rRNA interface [nucleotide binding]; other site 264732007524 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264732007525 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264732007526 mRNA/rRNA interface [nucleotide binding]; other site 264732007527 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264732007528 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264732007529 23S rRNA interface [nucleotide binding]; other site 264732007530 L7/L12 interface [polypeptide binding]; other site 264732007531 putative thiostrepton binding site; other site 264732007532 L25 interface [polypeptide binding]; other site 264732007533 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264732007534 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264732007535 putative homodimer interface [polypeptide binding]; other site 264732007536 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264732007537 heterodimer interface [polypeptide binding]; other site 264732007538 homodimer interface [polypeptide binding]; other site 264732007539 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 264732007540 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 264732007541 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 264732007542 GTP-binding protein YchF; Reviewed; Region: PRK09601 264732007543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 264732007544 G1 box; other site 264732007545 GTP/Mg2+ binding site [chemical binding]; other site 264732007546 G2 box; other site 264732007547 Switch I region; other site 264732007548 G3 box; other site 264732007549 Switch II region; other site 264732007550 G4 box; other site 264732007551 G5 box; other site 264732007552 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264732007553 Sulfate transporter family; Region: Sulfate_transp; cl19250 264732007554 xanthine permease; Region: pbuX; TIGR03173 264732007555 RNA polymerase factor sigma-70; Validated; Region: PRK08295 264732007556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264732007557 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264732007558 YacP-like NYN domain; Region: NYN_YacP; pfam05991 264732007559 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 264732007560 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 264732007561 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264732007562 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 264732007563 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 264732007564 active site 264732007565 metal binding site [ion binding]; metal-binding site 264732007566 dimerization interface [polypeptide binding]; other site 264732007567 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264732007568 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264732007569 active site 264732007570 HIGH motif; other site 264732007571 KMSKS motif; other site 264732007572 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264732007573 tRNA binding surface [nucleotide binding]; other site 264732007574 anticodon binding site; other site 264732007575 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 264732007576 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 264732007577 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264732007578 trimer interface [polypeptide binding]; other site 264732007579 active site 264732007580 substrate binding site [chemical binding]; other site 264732007581 CoA binding site [chemical binding]; other site 264732007582 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264732007583 homotrimer interaction site [polypeptide binding]; other site 264732007584 zinc binding site [ion binding]; other site 264732007585 CDP-binding sites; other site 264732007586 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264732007587 substrate binding site; other site 264732007588 dimer interface; other site 264732007589 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 264732007590 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 264732007591 putative active site [active] 264732007592 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 264732007593 DNA repair protein RadA; Provisional; Region: PRK11823 264732007594 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264732007595 Walker A motif/ATP binding site; other site 264732007596 ATP binding site [chemical binding]; other site 264732007597 Walker B motif; other site 264732007598 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264732007599 putative hydrolase; Validated; Region: PRK09248 264732007600 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 264732007601 active site 264732007602 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732007603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732007604 Zn2+ binding site [ion binding]; other site 264732007605 Mg2+ binding site [ion binding]; other site 264732007606 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264732007607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264732007608 dimerization interface [polypeptide binding]; other site 264732007609 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264732007610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264732007611 putative active site [active] 264732007612 heme pocket [chemical binding]; other site 264732007613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264732007614 dimer interface [polypeptide binding]; other site 264732007615 phosphorylation site [posttranslational modification] 264732007616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264732007617 ATP binding site [chemical binding]; other site 264732007618 Mg2+ binding site [ion binding]; other site 264732007619 G-X-G motif; other site 264732007620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732007621 Zn2+ binding site [ion binding]; other site 264732007622 Mg2+ binding site [ion binding]; other site 264732007623 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264732007624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264732007625 Zn2+ binding site [ion binding]; other site 264732007626 Mg2+ binding site [ion binding]; other site 264732007627 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 264732007628 Domain of unknown function DUF77; Region: DUF77; pfam01910 264732007629 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264732007630 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264732007631 Walker A/P-loop; other site 264732007632 ATP binding site [chemical binding]; other site 264732007633 Q-loop/lid; other site 264732007634 ABC transporter signature motif; other site 264732007635 Walker B; other site 264732007636 D-loop; other site 264732007637 H-loop/switch region; other site 264732007638 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264732007639 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264732007640 Walker A/P-loop; other site 264732007641 ATP binding site [chemical binding]; other site 264732007642 Q-loop/lid; other site 264732007643 ABC transporter signature motif; other site 264732007644 Walker B; other site 264732007645 D-loop; other site 264732007646 H-loop/switch region; other site 264732007647 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264732007648 TM-ABC transporter signature motif; other site 264732007649 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264732007650 TM-ABC transporter signature motif; other site 264732007651 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 264732007652 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 264732007653 putative ligand binding site [chemical binding]; other site 264732007654 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 264732007655 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 264732007656 G1 box; other site 264732007657 putative GEF interaction site [polypeptide binding]; other site 264732007658 GTP/Mg2+ binding site [chemical binding]; other site 264732007659 Switch I region; other site 264732007660 G2 box; other site 264732007661 G3 box; other site 264732007662 Switch II region; other site 264732007663 G4 box; other site 264732007664 G5 box; other site 264732007665 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 264732007666 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 264732007667 Elongation factor SelB, winged helix; Region: SelB-wing_1; pfam09105 264732007668 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 264732007669 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 264732007670 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 264732007671 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 264732007672 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 264732007673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264732007674 catalytic residue [active] 264732007675 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264732007676 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264732007677 putative dimer interface [polypeptide binding]; other site 264732007678 Sporulation and spore germination; Region: Germane; pfam10646 264732007679 Sporulation and spore germination; Region: Germane; pfam10646 264732007680 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264732007681 Germination protease; Region: Peptidase_A25; cl04057 264732007682 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 264732007683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264732007684 active site 264732007685 Protein of unknown function (DUF4446); Region: DUF4446; pfam14584 264732007686 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 264732007687 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 264732007688 Ligand Binding Site [chemical binding]; other site 264732007689 Protein of unknown function DUF111; Region: DUF111; pfam01969 264732007690 Protein of unknown function (DUF554); Region: DUF554; pfam04474 264732007691 Pyruvate kinase, alpha/beta domain; Region: PK_C; cl19522 264732007692 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264732007693 ParB-like nuclease domain; Region: ParBc; pfam02195 264732007694 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264732007695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264732007696 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264732007697 P-loop; other site 264732007698 Magnesium ion binding site [ion binding]; other site 264732007699 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264732007700 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264732007701 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 264732007702 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 264732007703 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264732007704 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264732007705 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264732007706 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264732007707 G1 box; other site 264732007708 GTP/Mg2+ binding site [chemical binding]; other site 264732007709 Switch I region; other site 264732007710 G2 box; other site 264732007711 Switch II region; other site 264732007712 G3 box; other site 264732007713 G4 box; other site 264732007714 G5 box; other site 264732007715 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264732007716 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 264732007717 Jag N-terminus; Region: Jag_N; pfam14804 264732007718 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 264732007719 G-X-X-G motif; other site 264732007720 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 264732007721 RxxxH motif; other site 264732007722 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264732007723 Haemolytic domain; Region: Haemolytic; pfam01809 264732007724 Ribonuclease P; Region: Ribonuclease_P; pfam00825