-- dump date 20140619_150355 -- class Genbank::misc_feature -- table misc_feature_note -- id note 749219000001 Ribonuclease P; Region: Ribonuclease_P; cl00457 749219000002 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 749219000003 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 749219000004 DnaA N-terminal domain; Region: DnaA_N; pfam11638 749219000005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000006 Walker A motif; other site 749219000007 ATP binding site [chemical binding]; other site 749219000008 Walker B motif; other site 749219000009 arginine finger; other site 749219000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 749219000011 DnaA box-binding interface [nucleotide binding]; other site 749219000012 DNA polymerase III subunit beta; Validated; Region: PRK05643 749219000013 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 749219000014 putative DNA binding surface [nucleotide binding]; other site 749219000015 dimer interface [polypeptide binding]; other site 749219000016 beta-clamp/clamp loader binding surface; other site 749219000017 beta-clamp/translesion DNA polymerase binding surface; other site 749219000018 recombination protein F; Reviewed; Region: recF; PRK00064 749219000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219000020 Walker A/P-loop; other site 749219000021 ATP binding site [chemical binding]; other site 749219000022 Q-loop/lid; other site 749219000023 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 749219000024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000025 Mg2+ binding site [ion binding]; other site 749219000026 G-X-G motif; other site 749219000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 749219000028 anchoring element; other site 749219000029 dimer interface [polypeptide binding]; other site 749219000030 ATP binding site [chemical binding]; other site 749219000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 749219000032 active site 749219000033 putative metal-binding site [ion binding]; other site 749219000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749219000035 GMP synthase; Reviewed; Region: guaA; PRK00074 749219000036 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 749219000037 AMP/PPi binding site [chemical binding]; other site 749219000038 candidate oxyanion hole; other site 749219000039 catalytic triad [active] 749219000040 potential glutamine specificity residues [chemical binding]; other site 749219000041 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 749219000042 ATP Binding subdomain [chemical binding]; other site 749219000043 Ligand Binding sites [chemical binding]; other site 749219000044 Dimerization subdomain; other site 749219000045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 749219000046 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 749219000047 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749219000048 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749219000049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 749219000050 dimer interface [polypeptide binding]; other site 749219000051 active site 749219000052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219000053 catalytic residues [active] 749219000054 substrate binding site [chemical binding]; other site 749219000055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000057 homodimer interface [polypeptide binding]; other site 749219000058 catalytic residue [active] 749219000059 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 749219000060 homotrimer interaction site [polypeptide binding]; other site 749219000061 putative active site [active] 749219000062 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 749219000063 hydroxyglutarate oxidase; Provisional; Region: PRK11728 749219000064 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 749219000065 ThiC-associated domain; Region: ThiC-associated; pfam13667 749219000066 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 749219000067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749219000068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749219000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219000070 Walker A/P-loop; other site 749219000071 ATP binding site [chemical binding]; other site 749219000072 Q-loop/lid; other site 749219000073 ABC transporter signature motif; other site 749219000074 Walker B; other site 749219000075 D-loop; other site 749219000076 H-loop/switch region; other site 749219000077 argininosuccinate lyase; Provisional; Region: PRK00855 749219000078 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 749219000079 active sites [active] 749219000080 tetramer interface [polypeptide binding]; other site 749219000081 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 749219000082 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 749219000083 domain interfaces; other site 749219000084 active site 749219000085 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 749219000086 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 749219000087 active site 749219000088 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 749219000089 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 749219000090 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749219000091 Protein of unknown function (DUF539); Region: DUF539; pfam04400 749219000092 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 749219000093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749219000094 nucleotide binding site [chemical binding]; other site 749219000095 GrpE; Region: GrpE; pfam01025 749219000096 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 749219000097 dimer interface [polypeptide binding]; other site 749219000098 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 749219000099 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 749219000100 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 749219000101 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 749219000102 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 749219000103 CRISPR-associated protein (Cas_Csy2); Region: Cas_Csy2; pfam09614 749219000104 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 749219000105 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 749219000106 Bacterial Fe(2+) trafficking; Region: Iron_traffic; pfam04362 749219000107 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749219000108 active site 749219000109 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 749219000110 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219000111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219000112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219000113 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 749219000114 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 749219000115 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 749219000116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749219000117 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749219000118 Walker A/P-loop; other site 749219000119 ATP binding site [chemical binding]; other site 749219000120 Q-loop/lid; other site 749219000121 ABC transporter signature motif; other site 749219000122 Walker B; other site 749219000123 D-loop; other site 749219000124 H-loop/switch region; other site 749219000125 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749219000126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000127 dimer interface [polypeptide binding]; other site 749219000128 conserved gate region; other site 749219000129 putative PBP binding loops; other site 749219000130 ABC-ATPase subunit interface; other site 749219000131 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749219000132 NMT1-like family; Region: NMT1_2; pfam13379 749219000133 Rubredoxin [Energy production and conversion]; Region: COG1773 749219000134 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 749219000135 iron binding site [ion binding]; other site 749219000136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749219000137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 749219000138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749219000140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749219000141 active site 749219000142 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749219000143 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749219000144 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 749219000145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219000146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219000147 ABC transporter; Region: ABC_tran_2; pfam12848 749219000148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219000149 chaperone protein DnaJ; Provisional; Region: PRK14299 749219000150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000151 HSP70 interaction site [polypeptide binding]; other site 749219000152 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 749219000153 dimer interface [polypeptide binding]; other site 749219000154 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 749219000155 dihydrodipicolinate reductase; Provisional; Region: PRK00048 749219000156 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 749219000157 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 749219000158 cystathionine beta-lyase; Provisional; Region: PRK07050 749219000159 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219000160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000161 catalytic residue [active] 749219000162 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 749219000163 Sodium Bile acid symporter family; Region: SBF; pfam01758 749219000164 chaperone protein DnaJ; Provisional; Region: PRK10767 749219000165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000166 HSP70 interaction site [polypeptide binding]; other site 749219000167 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 749219000168 substrate binding site [polypeptide binding]; other site 749219000169 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 749219000170 Zn binding sites [ion binding]; other site 749219000171 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 749219000172 dimer interface [polypeptide binding]; other site 749219000173 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 749219000174 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 749219000175 dimerization domain [polypeptide binding]; other site 749219000176 dimer interface [polypeptide binding]; other site 749219000177 catalytic residues [active] 749219000178 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 749219000179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219000180 RNA binding surface [nucleotide binding]; other site 749219000181 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 749219000182 active site 749219000183 uracil binding [chemical binding]; other site 749219000184 Uncharacterized conserved protein [Function unknown]; Region: COG1739 749219000185 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 749219000186 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 749219000187 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 749219000188 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 749219000189 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 749219000190 active site 749219000191 serine/threonine transporter SstT; Provisional; Region: PRK13628 749219000192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 749219000193 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 749219000194 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 749219000195 osmolarity response regulator; Provisional; Region: ompR; PRK09468 749219000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000197 active site 749219000198 phosphorylation site [posttranslational modification] 749219000199 intermolecular recognition site; other site 749219000200 dimerization interface [polypeptide binding]; other site 749219000201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219000202 DNA binding site [nucleotide binding] 749219000203 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 749219000204 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 749219000205 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 749219000206 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 749219000207 RNA binding site [nucleotide binding]; other site 749219000208 Domain of unknown function (DUF305); Region: DUF305; cl17794 749219000209 Domain of unknown function (DUF305); Region: DUF305; pfam03713 749219000210 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 749219000211 dimer interface [polypeptide binding]; other site 749219000212 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 749219000213 active site 749219000214 citrylCoA binding site [chemical binding]; other site 749219000215 NADH binding [chemical binding]; other site 749219000216 cationic pore residues; other site 749219000217 oxalacetate/citrate binding site [chemical binding]; other site 749219000218 coenzyme A binding site [chemical binding]; other site 749219000219 catalytic triad [active] 749219000220 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 749219000221 Iron-sulfur protein interface; other site 749219000222 proximal quinone binding site [chemical binding]; other site 749219000223 SdhD (CybS) interface [polypeptide binding]; other site 749219000224 proximal heme binding site [chemical binding]; other site 749219000225 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 749219000226 SdhC subunit interface [polypeptide binding]; other site 749219000227 proximal heme binding site [chemical binding]; other site 749219000228 cardiolipin binding site; other site 749219000229 Iron-sulfur protein interface; other site 749219000230 proximal quinone binding site [chemical binding]; other site 749219000231 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 749219000232 L-aspartate oxidase; Provisional; Region: PRK06175 749219000233 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749219000234 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 749219000235 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 749219000236 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 749219000237 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 749219000238 TPP-binding site [chemical binding]; other site 749219000239 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 749219000240 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 749219000241 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219000242 E3 interaction surface; other site 749219000243 lipoyl attachment site [posttranslational modification]; other site 749219000244 e3 binding domain; Region: E3_binding; pfam02817 749219000245 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749219000246 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 749219000247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000248 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219000249 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 749219000250 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 749219000251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219000252 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 749219000253 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219000254 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219000255 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 749219000256 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749219000257 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 749219000258 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 749219000259 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 749219000260 active site 749219000261 Zn binding site [ion binding]; other site 749219000262 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 749219000263 putative catalytic site [active] 749219000264 putative metal binding site [ion binding]; other site 749219000265 putative phosphate binding site [ion binding]; other site 749219000266 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 749219000267 active site 749219000268 dimerization interface [polypeptide binding]; other site 749219000269 trigger factor; Provisional; Region: tig; PRK01490 749219000270 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749219000271 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 749219000272 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 749219000273 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 749219000274 oligomer interface [polypeptide binding]; other site 749219000275 active site residues [active] 749219000276 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 749219000277 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 749219000278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000279 Walker A motif; other site 749219000280 ATP binding site [chemical binding]; other site 749219000281 Walker B motif; other site 749219000282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 749219000283 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000284 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 749219000285 HSP70 interaction site [polypeptide binding]; other site 749219000286 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 749219000287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749219000288 substrate binding site [chemical binding]; other site 749219000289 oxyanion hole (OAH) forming residues; other site 749219000290 trimer interface [polypeptide binding]; other site 749219000291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749219000292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749219000293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749219000294 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 749219000295 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749219000296 dimer interface [polypeptide binding]; other site 749219000297 active site 749219000298 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 749219000299 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749219000300 Active Sites [active] 749219000301 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 749219000302 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749219000303 Active Sites [active] 749219000304 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 749219000305 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 749219000306 CysD dimerization site [polypeptide binding]; other site 749219000307 G1 box; other site 749219000308 putative GEF interaction site [polypeptide binding]; other site 749219000309 GTP/Mg2+ binding site [chemical binding]; other site 749219000310 Switch I region; other site 749219000311 G2 box; other site 749219000312 G3 box; other site 749219000313 Switch II region; other site 749219000314 G4 box; other site 749219000315 G5 box; other site 749219000316 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 749219000317 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 749219000318 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 749219000319 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 749219000320 ssDNA binding site; other site 749219000321 generic binding surface II; other site 749219000322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219000323 ATP binding site [chemical binding]; other site 749219000324 putative Mg++ binding site [ion binding]; other site 749219000325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219000326 nucleotide binding region [chemical binding]; other site 749219000327 ATP-binding site [chemical binding]; other site 749219000328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749219000329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749219000330 ligand binding site [chemical binding]; other site 749219000331 flexible hinge region; other site 749219000332 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 749219000333 potential frameshift: common BLAST hit: gi|93007224|ref|YP_581661.1| secretion protein HlyD 749219000334 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219000335 E3 interaction surface; other site 749219000336 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219000337 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 749219000338 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 749219000339 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 749219000340 CoA-binding site [chemical binding]; other site 749219000341 ATP-binding [chemical binding]; other site 749219000342 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 749219000343 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 749219000344 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 749219000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 749219000346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 749219000347 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 749219000348 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 749219000349 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 749219000350 Walker A motif; other site 749219000351 ATP binding site [chemical binding]; other site 749219000352 Walker B motif; other site 749219000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219000354 putative substrate translocation pore; other site 749219000355 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 749219000356 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 749219000357 dimerization interface [polypeptide binding]; other site 749219000358 ATP binding site [chemical binding]; other site 749219000359 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 749219000360 dimerization interface [polypeptide binding]; other site 749219000361 ATP binding site [chemical binding]; other site 749219000362 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 749219000363 putative active site [active] 749219000364 catalytic triad [active] 749219000365 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 749219000366 N-acetylglutamate synthase; Validated; Region: PRK05279 749219000367 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 749219000368 putative feedback inhibition sensing region; other site 749219000369 putative nucleotide binding site [chemical binding]; other site 749219000370 putative substrate binding site [chemical binding]; other site 749219000371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219000372 Coenzyme A binding pocket [chemical binding]; other site 749219000373 Imelysin; Region: Peptidase_M75; pfam09375 749219000374 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 749219000375 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 749219000376 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 749219000377 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219000378 FMN binding site [chemical binding]; other site 749219000379 active site 749219000380 catalytic residues [active] 749219000381 substrate binding site [chemical binding]; other site 749219000382 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 749219000383 AAA domain; Region: AAA_30; pfam13604 749219000384 Family description; Region: UvrD_C_2; pfam13538 749219000385 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 749219000386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749219000387 DNA-binding site [nucleotide binding]; DNA binding site 749219000388 UTRA domain; Region: UTRA; pfam07702 749219000389 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 749219000390 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 749219000391 active site 749219000392 FMN binding site [chemical binding]; other site 749219000393 substrate binding site [chemical binding]; other site 749219000394 3Fe-4S cluster binding site [ion binding]; other site 749219000395 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 749219000396 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 749219000397 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 749219000398 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 749219000399 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 749219000400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 749219000401 metal binding site [ion binding]; metal-binding site 749219000402 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 749219000403 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 749219000404 23S rRNA binding site [nucleotide binding]; other site 749219000405 L21 binding site [polypeptide binding]; other site 749219000406 L13 binding site [polypeptide binding]; other site 749219000407 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 749219000408 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 749219000409 Putative water exit pathway; other site 749219000410 Binuclear center (active site) [active] 749219000411 K-pathway; other site 749219000412 Putative proton exit pathway; other site 749219000413 Predicted transcriptional regulator [Transcription]; Region: COG1959 749219000414 Transcriptional regulator; Region: Rrf2; cl17282 749219000415 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 749219000416 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 749219000417 Multicopper oxidase; Region: Cu-oxidase; pfam00394 749219000418 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 749219000419 Cytochrome c; Region: Cytochrom_C; pfam00034 749219000420 Uncharacterized conserved protein [Function unknown]; Region: COG1262 749219000421 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 749219000422 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 749219000423 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 749219000424 Cu(I) binding site [ion binding]; other site 749219000425 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 749219000426 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 749219000427 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 749219000428 dimer interface [polypeptide binding]; other site 749219000429 motif 1; other site 749219000430 active site 749219000431 motif 2; other site 749219000432 motif 3; other site 749219000433 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 749219000434 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 749219000435 putative tRNA-binding site [nucleotide binding]; other site 749219000436 B3/4 domain; Region: B3_4; pfam03483 749219000437 tRNA synthetase B5 domain; Region: B5; smart00874 749219000438 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 749219000439 dimer interface [polypeptide binding]; other site 749219000440 motif 1; other site 749219000441 motif 3; other site 749219000442 motif 2; other site 749219000443 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 749219000444 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219000445 IHF - DNA interface [nucleotide binding]; other site 749219000446 IHF dimer interface [polypeptide binding]; other site 749219000447 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 749219000448 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 749219000449 FtsZ protein binding site [polypeptide binding]; other site 749219000450 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 749219000451 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 749219000452 DNA binding site [nucleotide binding] 749219000453 catalytic residue [active] 749219000454 H2TH interface [polypeptide binding]; other site 749219000455 putative catalytic residues [active] 749219000456 turnover-facilitating residue; other site 749219000457 intercalation triad [nucleotide binding]; other site 749219000458 8OG recognition residue [nucleotide binding]; other site 749219000459 putative reading head residues; other site 749219000460 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749219000461 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749219000462 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749219000463 HD domain; Region: HD_4; pfam13328 749219000464 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749219000465 synthetase active site [active] 749219000466 NTP binding site [chemical binding]; other site 749219000467 metal binding site [ion binding]; metal-binding site 749219000468 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 749219000469 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 749219000470 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 749219000471 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749219000472 ATP binding site [chemical binding]; other site 749219000473 Mg++ binding site [ion binding]; other site 749219000474 motif III; other site 749219000475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219000476 nucleotide binding region [chemical binding]; other site 749219000477 ATP-binding site [chemical binding]; other site 749219000478 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 749219000479 TRAM domain; Region: TRAM; pfam01938 749219000480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219000481 S-adenosylmethionine binding site [chemical binding]; other site 749219000482 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 749219000483 active site 749219000484 catalytic site [active] 749219000485 substrate binding site [chemical binding]; other site 749219000486 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 749219000487 cysteine synthase B; Region: cysM; TIGR01138 749219000488 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749219000489 dimer interface [polypeptide binding]; other site 749219000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000491 catalytic residue [active] 749219000492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219000493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219000494 dimer interface [polypeptide binding]; other site 749219000495 phosphorylation site [posttranslational modification] 749219000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000497 ATP binding site [chemical binding]; other site 749219000498 Mg2+ binding site [ion binding]; other site 749219000499 G-X-G motif; other site 749219000500 Response regulator receiver domain; Region: Response_reg; pfam00072 749219000501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000502 active site 749219000503 phosphorylation site [posttranslational modification] 749219000504 intermolecular recognition site; other site 749219000505 dimerization interface [polypeptide binding]; other site 749219000506 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 749219000507 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 749219000508 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 749219000509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 749219000510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219000511 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 749219000512 inhibitor-cofactor binding pocket; inhibition site 749219000513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000514 catalytic residue [active] 749219000515 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 749219000516 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 749219000517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000518 catalytic residue [active] 749219000519 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 749219000520 Methyltransferase domain; Region: Methyltransf_11; pfam08241 749219000521 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 749219000522 AAA domain; Region: AAA_26; pfam13500 749219000523 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 749219000524 putative active site [active] 749219000525 dimerization interface [polypeptide binding]; other site 749219000526 putative tRNAtyr binding site [nucleotide binding]; other site 749219000527 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749219000528 nudix motif; other site 749219000529 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 749219000530 putative active site [active] 749219000531 putative CoA binding site [chemical binding]; other site 749219000532 nudix motif; other site 749219000533 metal binding site [ion binding]; metal-binding site 749219000534 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 749219000535 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 749219000536 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 749219000537 active site 749219000538 (T/H)XGH motif; other site 749219000539 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 749219000540 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 749219000541 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 749219000542 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 749219000543 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 749219000544 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749219000545 dimer interface [polypeptide binding]; other site 749219000546 ssDNA binding site [nucleotide binding]; other site 749219000547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749219000548 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 749219000549 heme exporter protein CcmC; Region: ccmC; TIGR01191 749219000550 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 749219000551 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 749219000552 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 749219000553 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 749219000554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000555 dimer interface [polypeptide binding]; other site 749219000556 conserved gate region; other site 749219000557 ABC-ATPase subunit interface; other site 749219000558 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 749219000559 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 749219000560 Walker A/P-loop; other site 749219000561 ATP binding site [chemical binding]; other site 749219000562 Q-loop/lid; other site 749219000563 ABC transporter signature motif; other site 749219000564 Walker B; other site 749219000565 D-loop; other site 749219000566 H-loop/switch region; other site 749219000567 NIL domain; Region: NIL; pfam09383 749219000568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219000569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749219000570 dimerization interface [polypeptide binding]; other site 749219000571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219000572 dimer interface [polypeptide binding]; other site 749219000573 phosphorylation site [posttranslational modification] 749219000574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000575 ATP binding site [chemical binding]; other site 749219000576 G-X-G motif; other site 749219000577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749219000578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000579 active site 749219000580 phosphorylation site [posttranslational modification] 749219000581 intermolecular recognition site; other site 749219000582 dimerization interface [polypeptide binding]; other site 749219000583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219000584 DNA binding site [nucleotide binding] 749219000585 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 749219000586 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219000587 lipoyl-biotinyl attachment site [posttranslational modification]; other site 749219000588 HlyD family secretion protein; Region: HlyD_3; pfam13437 749219000589 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 749219000590 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 749219000591 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 749219000592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219000593 active site 749219000594 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 749219000595 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 749219000596 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 749219000597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219000598 binding surface 749219000599 TPR motif; other site 749219000600 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 749219000601 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 749219000602 tRNA; other site 749219000603 putative tRNA binding site [nucleotide binding]; other site 749219000604 putative NADP binding site [chemical binding]; other site 749219000605 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 749219000606 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 749219000607 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 749219000608 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 749219000609 glutamate racemase; Provisional; Region: PRK00865 749219000610 Dot/Icm substrate protein; Region: SidE; pfam12252 749219000611 fungal transcription factor regulatory middle homology region; Region: fungal_TF_MHR; cl17093 749219000612 Transglycosylase SLT domain; Region: SLT_2; pfam13406 749219000613 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749219000614 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219000615 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 749219000616 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749219000617 methionine sulfoxide reductase A; Provisional; Region: PRK14054 749219000618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219000619 S-adenosylmethionine binding site [chemical binding]; other site 749219000620 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749219000621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219000622 S-adenosylmethionine binding site [chemical binding]; other site 749219000623 Protein of unknown function (DUF808); Region: DUF808; pfam05661 749219000624 Sporulation related domain; Region: SPOR; cl10051 749219000625 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 749219000626 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 749219000627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000628 catalytic residue [active] 749219000629 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 749219000630 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 749219000631 metal binding site [ion binding]; metal-binding site 749219000632 dimer interface [polypeptide binding]; other site 749219000633 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749219000634 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749219000635 hypothetical protein; Provisional; Region: PRK05170 749219000636 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 749219000637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219000638 Transporter associated domain; Region: CorC_HlyC; smart01091 749219000639 putative global regulator; Reviewed; Region: PRK09559 749219000640 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 749219000641 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 749219000642 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 749219000643 PhnA protein; Region: PhnA; pfam03831 749219000644 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 749219000645 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219000646 inhibitor-cofactor binding pocket; inhibition site 749219000647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000648 catalytic residue [active] 749219000649 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 749219000650 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 749219000651 SEC-C motif; Region: SEC-C; pfam02810 749219000652 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 749219000653 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 749219000654 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 749219000655 putative active site [active] 749219000656 catalytic triad [active] 749219000657 putative dimer interface [polypeptide binding]; other site 749219000658 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219000659 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219000660 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 749219000661 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 749219000662 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219000663 Protein of unknown function (DUF560); Region: DUF560; pfam04575 749219000664 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749219000665 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 749219000666 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749219000667 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 749219000668 active site 749219000669 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 749219000670 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 749219000671 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 749219000672 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749219000673 dimer interface [polypeptide binding]; other site 749219000674 active site 749219000675 MAEBL; Provisional; Region: PTZ00121 749219000676 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 749219000677 S17 interaction site [polypeptide binding]; other site 749219000678 S8 interaction site; other site 749219000679 16S rRNA interaction site [nucleotide binding]; other site 749219000680 streptomycin interaction site [chemical binding]; other site 749219000681 23S rRNA interaction site [nucleotide binding]; other site 749219000682 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 749219000683 30S ribosomal protein S7; Validated; Region: PRK05302 749219000684 elongation factor G; Reviewed; Region: PRK00007 749219000685 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 749219000686 G1 box; other site 749219000687 putative GEF interaction site [polypeptide binding]; other site 749219000688 GTP/Mg2+ binding site [chemical binding]; other site 749219000689 Switch I region; other site 749219000690 G2 box; other site 749219000691 G3 box; other site 749219000692 Switch II region; other site 749219000693 G4 box; other site 749219000694 G5 box; other site 749219000695 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 749219000696 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 749219000697 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 749219000698 elongation factor Tu; Reviewed; Region: PRK00049 749219000699 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749219000700 G1 box; other site 749219000701 GEF interaction site [polypeptide binding]; other site 749219000702 GTP/Mg2+ binding site [chemical binding]; other site 749219000703 Switch I region; other site 749219000704 G2 box; other site 749219000705 G3 box; other site 749219000706 Switch II region; other site 749219000707 G4 box; other site 749219000708 G5 box; other site 749219000709 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749219000710 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 749219000711 Antibiotic Binding Site [chemical binding]; other site 749219000712 thioredoxin reductase; Provisional; Region: PRK10262 749219000713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 749219000714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000715 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 749219000716 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 749219000717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749219000718 active site 749219000719 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 749219000720 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 749219000721 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 749219000722 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 749219000723 shikimate binding site; other site 749219000724 NAD(P) binding site [chemical binding]; other site 749219000725 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 749219000726 substrate-cofactor binding pocket; other site 749219000727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000728 homodimer interface [polypeptide binding]; other site 749219000729 catalytic residue [active] 749219000730 YceG-like family; Region: YceG; pfam02618 749219000731 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 749219000732 dimerization interface [polypeptide binding]; other site 749219000733 thymidylate kinase; Validated; Region: tmk; PRK00698 749219000734 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 749219000735 TMP-binding site; other site 749219000736 ATP-binding site [chemical binding]; other site 749219000737 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 749219000738 dihydrodipicolinate synthase; Region: dapA; TIGR00674 749219000739 dimer interface [polypeptide binding]; other site 749219000740 active site 749219000741 catalytic residue [active] 749219000742 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 749219000743 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 749219000744 ATP binding site [chemical binding]; other site 749219000745 active site 749219000746 substrate binding site [chemical binding]; other site 749219000747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 749219000748 anthranilate synthase component I; Provisional; Region: PRK13565 749219000749 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 749219000750 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 749219000751 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749219000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000753 Walker A motif; other site 749219000754 ATP binding site [chemical binding]; other site 749219000755 Walker B motif; other site 749219000756 arginine finger; other site 749219000757 Predicted transcriptional regulator [Transcription]; Region: COG2378 749219000758 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749219000759 WYL domain; Region: WYL; pfam13280 749219000760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749219000761 non-specific DNA binding site [nucleotide binding]; other site 749219000762 salt bridge; other site 749219000763 sequence-specific DNA binding site [nucleotide binding]; other site 749219000764 elongation factor Tu; Reviewed; Region: PRK00049 749219000765 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749219000766 G1 box; other site 749219000767 GEF interaction site [polypeptide binding]; other site 749219000768 GTP/Mg2+ binding site [chemical binding]; other site 749219000769 Switch I region; other site 749219000770 G2 box; other site 749219000771 G3 box; other site 749219000772 Switch II region; other site 749219000773 G4 box; other site 749219000774 G5 box; other site 749219000775 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749219000776 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 749219000777 Antibiotic Binding Site [chemical binding]; other site 749219000778 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 749219000779 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 749219000780 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 749219000781 putative homodimer interface [polypeptide binding]; other site 749219000782 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 749219000783 heterodimer interface [polypeptide binding]; other site 749219000784 homodimer interface [polypeptide binding]; other site 749219000785 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 749219000786 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 749219000787 23S rRNA interface [nucleotide binding]; other site 749219000788 L7/L12 interface [polypeptide binding]; other site 749219000789 putative thiostrepton binding site; other site 749219000790 L25 interface [polypeptide binding]; other site 749219000791 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 749219000792 mRNA/rRNA interface [nucleotide binding]; other site 749219000793 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 749219000794 23S rRNA interface [nucleotide binding]; other site 749219000795 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 749219000796 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 749219000797 core dimer interface [polypeptide binding]; other site 749219000798 peripheral dimer interface [polypeptide binding]; other site 749219000799 L10 interface [polypeptide binding]; other site 749219000800 L11 interface [polypeptide binding]; other site 749219000801 putative EF-Tu interaction site [polypeptide binding]; other site 749219000802 putative EF-G interaction site [polypeptide binding]; other site 749219000803 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 749219000804 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 749219000805 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 749219000806 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 749219000807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 749219000808 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 749219000809 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 749219000810 RPB3 interaction site [polypeptide binding]; other site 749219000811 RPB1 interaction site [polypeptide binding]; other site 749219000812 RPB11 interaction site [polypeptide binding]; other site 749219000813 RPB10 interaction site [polypeptide binding]; other site 749219000814 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 749219000815 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 749219000816 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 749219000817 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 749219000818 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 749219000819 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 749219000820 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 749219000821 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 749219000822 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 749219000823 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 749219000824 DNA binding site [nucleotide binding] 749219000825 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 749219000826 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 749219000827 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 749219000828 ligand binding site [chemical binding]; other site 749219000829 NAD binding site [chemical binding]; other site 749219000830 tetramer interface [polypeptide binding]; other site 749219000831 catalytic site [active] 749219000832 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 749219000833 L-serine binding site [chemical binding]; other site 749219000834 ACT domain interface; other site 749219000835 glutathione reductase; Validated; Region: PRK06116 749219000836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219000838 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749219000839 beta-hexosaminidase; Provisional; Region: PRK05337 749219000840 carboxy-terminal protease; Provisional; Region: PRK11186 749219000841 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 749219000842 protein binding site [polypeptide binding]; other site 749219000843 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 749219000844 Catalytic dyad [active] 749219000845 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 749219000846 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749219000847 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 749219000848 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 749219000849 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 749219000850 pantothenate kinase; Reviewed; Region: PRK13322 749219000851 MAPEG family; Region: MAPEG; cl09190 749219000852 OsmC-like protein; Region: OsmC; cl00767 749219000853 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 749219000854 putative active site [active] 749219000855 Ap4A binding site [chemical binding]; other site 749219000856 nudix motif; other site 749219000857 putative metal binding site [ion binding]; other site 749219000858 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 749219000859 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 749219000860 Walker A/P-loop; other site 749219000861 ATP binding site [chemical binding]; other site 749219000862 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 749219000863 ABC transporter signature motif; other site 749219000864 Walker B; other site 749219000865 D-loop; other site 749219000866 H-loop/switch region; other site 749219000867 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 749219000868 rRNA interaction site [nucleotide binding]; other site 749219000869 S8 interaction site; other site 749219000870 putative laminin-1 binding site; other site 749219000871 elongation factor Ts; Provisional; Region: tsf; PRK09377 749219000872 UBA/TS-N domain; Region: UBA; pfam00627 749219000873 Elongation factor TS; Region: EF_TS; pfam00889 749219000874 Elongation factor TS; Region: EF_TS; pfam00889 749219000875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219000876 active site 749219000877 glutathione synthetase; Provisional; Region: PRK05246 749219000878 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 749219000879 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 749219000880 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 749219000881 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 749219000882 active site 749219000883 homodimer interface [polypeptide binding]; other site 749219000884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 749219000885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219000886 Coenzyme A binding pocket [chemical binding]; other site 749219000887 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 749219000888 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219000889 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219000890 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219000891 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 749219000892 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 749219000893 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749219000894 Protein of unknown function DUF45; Region: DUF45; pfam01863 749219000895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219000896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219000897 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 749219000898 dimerization interface [polypeptide binding]; other site 749219000899 peroxiredoxin; Region: AhpC; TIGR03137 749219000900 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 749219000901 dimer interface [polypeptide binding]; other site 749219000902 decamer (pentamer of dimers) interface [polypeptide binding]; other site 749219000903 catalytic triad [active] 749219000904 peroxidatic and resolving cysteines [active] 749219000905 Protein of unknown function (DUF465); Region: DUF465; cl01070 749219000906 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 749219000907 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 749219000908 catalytic residue [active] 749219000909 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 749219000910 catalytic residues [active] 749219000911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 749219000912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000913 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 749219000914 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749219000915 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 749219000916 Walker A/P-loop; other site 749219000917 ATP binding site [chemical binding]; other site 749219000918 Q-loop/lid; other site 749219000919 ABC transporter signature motif; other site 749219000920 Walker B; other site 749219000921 D-loop; other site 749219000922 H-loop/switch region; other site 749219000923 TOBE domain; Region: TOBE_2; pfam08402 749219000924 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 749219000925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000926 dimer interface [polypeptide binding]; other site 749219000927 conserved gate region; other site 749219000928 putative PBP binding loops; other site 749219000929 ABC-ATPase subunit interface; other site 749219000930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000931 dimer interface [polypeptide binding]; other site 749219000932 conserved gate region; other site 749219000933 putative PBP binding loops; other site 749219000934 ABC-ATPase subunit interface; other site 749219000935 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 749219000936 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749219000937 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 749219000938 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 749219000939 metal binding site [ion binding]; metal-binding site 749219000940 dimer interface [polypeptide binding]; other site 749219000941 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 749219000942 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 749219000943 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 749219000944 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 749219000945 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 749219000946 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 749219000947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219000948 active site 749219000949 motif I; other site 749219000950 motif II; other site 749219000951 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749219000952 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 749219000953 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 749219000954 Cell division protein FtsQ; Region: FtsQ; pfam03799 749219000955 Cell division protein FtsA; Region: FtsA; cl17206 749219000956 cell division protein FtsA; Region: ftsA; TIGR01174 749219000957 Cell division protein FtsA; Region: FtsA; pfam14450 749219000958 cell division protein FtsZ; Validated; Region: PRK09330 749219000959 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 749219000960 nucleotide binding site [chemical binding]; other site 749219000961 SulA interaction site; other site 749219000962 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 749219000963 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 749219000964 active site 749219000965 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 749219000966 recombination regulator RecX; Reviewed; Region: recX; PRK00117 749219000967 recombinase A; Provisional; Region: recA; PRK09354 749219000968 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 749219000969 hexamer interface [polypeptide binding]; other site 749219000970 Walker A motif; other site 749219000971 ATP binding site [chemical binding]; other site 749219000972 Walker B motif; other site 749219000973 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749219000974 FAD binding domain; Region: FAD_binding_4; pfam01565 749219000975 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 749219000976 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 749219000977 active site 749219000978 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 749219000979 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 749219000980 putative ATP binding site [chemical binding]; other site 749219000981 putative substrate interface [chemical binding]; other site 749219000982 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 749219000983 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 749219000984 active site 749219000985 substrate binding site [chemical binding]; other site 749219000986 trimer interface [polypeptide binding]; other site 749219000987 CoA binding site [chemical binding]; other site 749219000988 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 749219000989 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 749219000990 lipoyl synthase; Provisional; Region: PRK05481 749219000991 ferrochelatase; Reviewed; Region: hemH; PRK00035 749219000992 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 749219000993 C-terminal domain interface [polypeptide binding]; other site 749219000994 active site 749219000995 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 749219000996 active site 749219000997 N-terminal domain interface [polypeptide binding]; other site 749219000998 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 749219000999 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 749219001000 UGMP family protein; Validated; Region: PRK09604 749219001001 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 749219001002 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 749219001003 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 749219001004 putative trimer interface [polypeptide binding]; other site 749219001005 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cd12813 749219001006 trimer interface [polypeptide binding]; other site 749219001007 putative trimer interface [polypeptide binding]; other site 749219001008 YadA-like C-terminal region; Region: YadA; pfam03895 749219001009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219001010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219001011 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 749219001012 putative dimerization interface [polypeptide binding]; other site 749219001013 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749219001014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749219001015 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 749219001016 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 749219001017 ferric uptake regulator; Provisional; Region: fur; PRK09462 749219001018 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749219001019 metal binding site 2 [ion binding]; metal-binding site 749219001020 putative DNA binding helix; other site 749219001021 metal binding site 1 [ion binding]; metal-binding site 749219001022 dimer interface [polypeptide binding]; other site 749219001023 structural Zn2+ binding site [ion binding]; other site 749219001024 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 749219001025 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 749219001026 Walker A motif; other site 749219001027 ATP binding site [chemical binding]; other site 749219001028 Walker B motif; other site 749219001029 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 749219001030 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219001031 catalytic residue [active] 749219001032 NAD synthetase; Provisional; Region: PRK13981 749219001033 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 749219001034 multimer interface [polypeptide binding]; other site 749219001035 active site 749219001036 catalytic triad [active] 749219001037 protein interface 1 [polypeptide binding]; other site 749219001038 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 749219001039 homodimer interface [polypeptide binding]; other site 749219001040 NAD binding pocket [chemical binding]; other site 749219001041 ATP binding pocket [chemical binding]; other site 749219001042 Mg binding site [ion binding]; other site 749219001043 active-site loop [active] 749219001044 Cell division protein ZapA; Region: ZapA; pfam05164 749219001045 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 749219001046 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 749219001047 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 749219001048 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 749219001049 active site 749219001050 Riboflavin kinase; Region: Flavokinase; smart00904 749219001051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001052 S-adenosylmethionine binding site [chemical binding]; other site 749219001053 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 749219001054 TraX protein; Region: TraX; cl05434 749219001055 primosome assembly protein PriA; Validated; Region: PRK05580 749219001056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219001057 ATP binding site [chemical binding]; other site 749219001058 putative Mg++ binding site [ion binding]; other site 749219001059 nucleotide binding region [chemical binding]; other site 749219001060 helicase superfamily c-terminal domain; Region: HELICc; smart00490 749219001061 ATP-binding site [chemical binding]; other site 749219001062 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749219001063 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 749219001064 homotrimer interaction site [polypeptide binding]; other site 749219001065 putative active site [active] 749219001066 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749219001067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749219001068 Zn2+ binding site [ion binding]; other site 749219001069 Mg2+ binding site [ion binding]; other site 749219001070 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 749219001071 metal binding triad [ion binding]; metal-binding site 749219001072 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 749219001073 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749219001074 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 749219001075 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 749219001076 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 749219001077 catalytic site [active] 749219001078 G-X2-G-X-G-K; other site 749219001079 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 749219001080 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 749219001081 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 749219001082 DHH family; Region: DHH; pfam01368 749219001083 DHHA1 domain; Region: DHHA1; pfam02272 749219001084 Predicted membrane protein [Function unknown]; Region: COG2860 749219001085 UPF0126 domain; Region: UPF0126; pfam03458 749219001086 UPF0126 domain; Region: UPF0126; pfam03458 749219001087 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 749219001088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219001089 FeS/SAM binding site; other site 749219001090 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 749219001091 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219001092 inhibitor-cofactor binding pocket; inhibition site 749219001093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219001094 catalytic residue [active] 749219001095 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 749219001096 DNA methylase; Region: N6_N4_Mtase; pfam01555 749219001097 DNA methylase; Region: N6_N4_Mtase; cl17433 749219001098 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 749219001099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219001100 ATP binding site [chemical binding]; other site 749219001101 putative Mg++ binding site [ion binding]; other site 749219001102 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219001103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219001104 catalytic residue [active] 749219001105 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 749219001106 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 749219001107 GIY-YIG motif/motif A; other site 749219001108 active site 749219001109 catalytic site [active] 749219001110 putative DNA binding site [nucleotide binding]; other site 749219001111 metal binding site [ion binding]; metal-binding site 749219001112 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 749219001113 phosphoglycolate phosphatase; Provisional; Region: PRK13222 749219001114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219001115 motif II; other site 749219001116 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 749219001117 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 749219001118 active site 749219001119 HIGH motif; other site 749219001120 nucleotide binding site [chemical binding]; other site 749219001121 active site 749219001122 KMSKS motif; other site 749219001123 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 749219001124 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 749219001125 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 749219001126 active site 749219001127 metal binding site [ion binding]; metal-binding site 749219001128 hexamer interface [polypeptide binding]; other site 749219001129 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 749219001130 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219001131 ABC-ATPase subunit interface; other site 749219001132 dimer interface [polypeptide binding]; other site 749219001133 putative PBP binding regions; other site 749219001134 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 749219001135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219001136 Walker A/P-loop; other site 749219001137 ATP binding site [chemical binding]; other site 749219001138 Q-loop/lid; other site 749219001139 ABC transporter signature motif; other site 749219001140 Walker B; other site 749219001141 D-loop; other site 749219001142 H-loop/switch region; other site 749219001143 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749219001144 metal binding site 2 [ion binding]; metal-binding site 749219001145 putative DNA binding helix; other site 749219001146 metal binding site 1 [ion binding]; metal-binding site 749219001147 dimer interface [polypeptide binding]; other site 749219001148 structural Zn2+ binding site [ion binding]; other site 749219001149 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 749219001150 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749219001151 intersubunit interface [polypeptide binding]; other site 749219001152 ATP synthase I chain; Region: ATP_synt_I; cl09170 749219001153 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 749219001154 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 749219001155 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 749219001156 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 749219001157 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 749219001158 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 749219001159 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 749219001160 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 749219001161 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 749219001162 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 749219001163 beta subunit interaction interface [polypeptide binding]; other site 749219001164 Walker A motif; other site 749219001165 ATP binding site [chemical binding]; other site 749219001166 Walker B motif; other site 749219001167 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749219001168 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 749219001169 core domain interface [polypeptide binding]; other site 749219001170 delta subunit interface [polypeptide binding]; other site 749219001171 epsilon subunit interface [polypeptide binding]; other site 749219001172 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 749219001173 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 749219001174 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 749219001175 alpha subunit interaction interface [polypeptide binding]; other site 749219001176 Walker A motif; other site 749219001177 ATP binding site [chemical binding]; other site 749219001178 Walker B motif; other site 749219001179 inhibitor binding site; inhibition site 749219001180 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749219001181 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 749219001182 LBP interface [polypeptide binding]; other site 749219001183 epsilon subunit interface [polypeptide binding]; other site 749219001184 gamma subunit interface [polypeptide binding]; other site 749219001185 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 749219001186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219001187 active site 749219001188 phosphorylation site [posttranslational modification] 749219001189 intermolecular recognition site; other site 749219001190 dimerization interface [polypeptide binding]; other site 749219001191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219001192 DNA binding site [nucleotide binding] 749219001193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219001194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749219001195 dimerization interface [polypeptide binding]; other site 749219001196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219001197 dimer interface [polypeptide binding]; other site 749219001198 phosphorylation site [posttranslational modification] 749219001199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001200 ATP binding site [chemical binding]; other site 749219001201 Mg2+ binding site [ion binding]; other site 749219001202 G-X-G motif; other site 749219001203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219001204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749219001205 dimerization interface [polypeptide binding]; other site 749219001206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219001207 dimer interface [polypeptide binding]; other site 749219001208 phosphorylation site [posttranslational modification] 749219001209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001210 ATP binding site [chemical binding]; other site 749219001211 Mg2+ binding site [ion binding]; other site 749219001212 G-X-G motif; other site 749219001213 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 749219001214 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 749219001215 RimM N-terminal domain; Region: RimM; pfam01782 749219001216 PRC-barrel domain; Region: PRC; pfam05239 749219001217 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 749219001218 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 749219001219 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 749219001220 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 749219001221 Pilin (bacterial filament); Region: Pilin; pfam00114 749219001222 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 749219001223 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 749219001224 substrate binding site [chemical binding]; other site 749219001225 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 749219001226 substrate binding site [chemical binding]; other site 749219001227 ligand binding site [chemical binding]; other site 749219001228 urocanate hydratase; Provisional; Region: PRK05414 749219001229 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 749219001230 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 749219001231 active sites [active] 749219001232 tetramer interface [polypeptide binding]; other site 749219001233 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 749219001234 putative active site [active] 749219001235 putative metal binding site [ion binding]; other site 749219001236 imidazolonepropionase; Validated; Region: PRK09356 749219001237 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 749219001238 active site 749219001239 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749219001240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 749219001241 Ligand binding site [chemical binding]; other site 749219001242 Electron transfer flavoprotein domain; Region: ETF; pfam01012 749219001243 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 749219001244 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 749219001245 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 749219001246 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749219001247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749219001248 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 749219001249 AMP binding site [chemical binding]; other site 749219001250 metal binding site [ion binding]; metal-binding site 749219001251 active site 749219001252 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 749219001253 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749219001254 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 749219001255 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 749219001256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219001257 TPR motif; other site 749219001258 binding surface 749219001259 Sel1-like repeats; Region: SEL1; smart00671 749219001260 Sel1-like repeats; Region: SEL1; smart00671 749219001261 Sel1-like repeats; Region: SEL1; smart00671 749219001262 dihydroorotase; Provisional; Region: PRK08417 749219001263 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 749219001264 active site 749219001265 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 749219001266 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749219001267 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 749219001268 motif 1; other site 749219001269 dimer interface [polypeptide binding]; other site 749219001270 active site 749219001271 motif 2; other site 749219001272 motif 3; other site 749219001273 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 749219001274 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 749219001275 ligand binding site [chemical binding]; other site 749219001276 NAD binding site [chemical binding]; other site 749219001277 catalytic site [active] 749219001278 homodimer interface [polypeptide binding]; other site 749219001279 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749219001280 Domain of unknown function DUF20; Region: UPF0118; pfam01594 749219001281 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 749219001282 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 749219001283 ATP-grasp domain; Region: ATP-grasp; pfam02222 749219001284 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 749219001285 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749219001286 active site 749219001287 metal binding site [ion binding]; metal-binding site 749219001288 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 749219001289 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 749219001290 active site 749219001291 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 749219001292 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 749219001293 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 749219001294 active site 749219001295 catalytic triad [active] 749219001296 oxyanion hole [active] 749219001297 Autotransporter beta-domain; Region: Autotransporter; pfam03797 749219001298 biotin synthase; Region: bioB; TIGR00433 749219001299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219001300 FeS/SAM binding site; other site 749219001301 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 749219001302 phosphoserine phosphatase SerB; Region: serB; TIGR00338 749219001303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219001304 motif II; other site 749219001305 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 749219001306 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 749219001307 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 749219001308 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 749219001309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219001310 FeS/SAM binding site; other site 749219001311 elongation factor P; Validated; Region: PRK00529 749219001312 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 749219001313 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 749219001314 RNA binding site [nucleotide binding]; other site 749219001315 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 749219001316 RNA binding site [nucleotide binding]; other site 749219001317 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 749219001318 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 749219001319 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 749219001320 putative ligand binding site [chemical binding]; other site 749219001321 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 749219001322 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 749219001323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001324 S-adenosylmethionine binding site [chemical binding]; other site 749219001325 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 749219001326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001327 Walker A motif; other site 749219001328 ATP binding site [chemical binding]; other site 749219001329 Walker B motif; other site 749219001330 arginine finger; other site 749219001331 Peptidase family M41; Region: Peptidase_M41; pfam01434 749219001332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749219001333 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 749219001334 putative acyl-acceptor binding pocket; other site 749219001335 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 749219001336 Transglycosylase; Region: Transgly; pfam00912 749219001337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749219001338 heat shock protein 90; Provisional; Region: PRK05218 749219001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001340 ATP binding site [chemical binding]; other site 749219001341 Mg2+ binding site [ion binding]; other site 749219001342 G-X-G motif; other site 749219001343 Peptidase C13 family; Region: Peptidase_C13; cl02159 749219001344 glutamate dehydrogenase; Provisional; Region: PRK09414 749219001345 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 749219001346 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 749219001347 NAD(P) binding pocket [chemical binding]; other site 749219001348 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 749219001349 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 749219001350 substrate binding site [chemical binding]; other site 749219001351 catalytic Zn binding site [ion binding]; other site 749219001352 NAD binding site [chemical binding]; other site 749219001353 structural Zn binding site [ion binding]; other site 749219001354 dimer interface [polypeptide binding]; other site 749219001355 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 749219001356 S-formylglutathione hydrolase; Region: PLN02442 749219001357 Family description; Region: DsbD_2; pfam13386 749219001358 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 749219001359 Uncharacterized conserved protein [Function unknown]; Region: COG0397 749219001360 hypothetical protein; Validated; Region: PRK00029 749219001361 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749219001362 Fatty acid desaturase; Region: FA_desaturase; pfam00487 749219001363 Di-iron ligands [ion binding]; other site 749219001364 B-Box C-terminal domain; Region: BBC; smart00502 749219001365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749219001366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749219001367 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749219001368 pteridine reductase; Provisional; Region: PRK09135 749219001369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001370 NAD(P) binding site [chemical binding]; other site 749219001371 active site 749219001372 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 749219001373 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 749219001374 active site 749219001375 NTP binding site [chemical binding]; other site 749219001376 metal binding triad [ion binding]; metal-binding site 749219001377 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 749219001378 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 749219001379 Malic enzyme, N-terminal domain; Region: malic; pfam00390 749219001380 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 749219001381 putative NAD(P) binding site [chemical binding]; other site 749219001382 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 749219001383 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 749219001384 dimer interface [polypeptide binding]; other site 749219001385 allosteric magnesium binding site [ion binding]; other site 749219001386 active site 749219001387 aspartate-rich active site metal binding site; other site 749219001388 Schiff base residues; other site 749219001389 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 749219001390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001391 Walker A motif; other site 749219001392 ATP binding site [chemical binding]; other site 749219001393 Walker B motif; other site 749219001394 arginine finger; other site 749219001395 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 749219001396 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 749219001397 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749219001398 dimer interface [polypeptide binding]; other site 749219001399 active site 749219001400 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 749219001401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001402 NAD(P) binding site [chemical binding]; other site 749219001403 active site 749219001404 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749219001405 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749219001406 active site 2 [active] 749219001407 active site 1 [active] 749219001408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 749219001409 Beta-lactamase; Region: Beta-lactamase; pfam00144 749219001410 Beta-lactamase; Region: Beta-lactamase; cl17358 749219001411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219001412 active site 749219001413 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 749219001414 BCCT family transporter; Region: BCCT; pfam02028 749219001415 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749219001416 Domain of unknown function DUF20; Region: UPF0118; pfam01594 749219001417 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 749219001418 HIT family signature motif; other site 749219001419 catalytic residue [active] 749219001420 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749219001421 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 749219001422 FAD binding pocket [chemical binding]; other site 749219001423 FAD binding motif [chemical binding]; other site 749219001424 phosphate binding motif [ion binding]; other site 749219001425 beta-alpha-beta structure motif; other site 749219001426 NAD binding pocket [chemical binding]; other site 749219001427 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 749219001428 homodimer interaction site [polypeptide binding]; other site 749219001429 cofactor binding site; other site 749219001430 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 749219001431 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 749219001432 HlyD family secretion protein; Region: HlyD_3; pfam13437 749219001433 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 749219001434 Protein export membrane protein; Region: SecD_SecF; cl14618 749219001435 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 749219001436 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 749219001437 putative metal binding site [ion binding]; other site 749219001438 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749219001439 FAD binding domain; Region: FAD_binding_4; pfam01565 749219001440 putative protease; Provisional; Region: PRK15452 749219001441 Peptidase family U32; Region: Peptidase_U32; pfam01136 749219001442 AAA domain; Region: AAA_21; pfam13304 749219001443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219001444 Walker B; other site 749219001445 D-loop; other site 749219001446 H-loop/switch region; other site 749219001447 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 749219001448 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 749219001449 Yqey-like protein; Region: YqeY; pfam09424 749219001450 Predicted methyltransferases [General function prediction only]; Region: COG0313 749219001451 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 749219001452 putative SAM binding site [chemical binding]; other site 749219001453 putative homodimer interface [polypeptide binding]; other site 749219001454 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 749219001455 G1 box; other site 749219001456 GTP/Mg2+ binding site [chemical binding]; other site 749219001457 Switch I region; other site 749219001458 G2 box; other site 749219001459 G3 box; other site 749219001460 Switch II region; other site 749219001461 G4 box; other site 749219001462 G5 box; other site 749219001463 homoserine dehydrogenase; Provisional; Region: PRK06349 749219001464 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 749219001465 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 749219001466 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 749219001467 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 749219001468 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 749219001469 dimerization domain [polypeptide binding]; other site 749219001470 dimer interface [polypeptide binding]; other site 749219001471 catalytic residues [active] 749219001472 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 749219001473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749219001474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 749219001475 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 749219001476 active site 749219001477 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219001478 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 749219001479 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 749219001480 Sel1-like repeats; Region: SEL1; smart00671 749219001481 Sel1-like repeats; Region: SEL1; smart00671 749219001482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001483 S-adenosylmethionine binding site [chemical binding]; other site 749219001484 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 749219001485 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 749219001486 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 749219001487 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749219001488 lipoprotein signal peptidase; Provisional; Region: PRK14785 749219001489 lipoprotein signal peptidase; Provisional; Region: PRK14787 749219001490 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001491 active site 749219001492 HIGH motif; other site 749219001493 nucleotide binding site [chemical binding]; other site 749219001494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749219001495 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749219001496 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219001497 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 749219001498 active site 749219001499 KMSKS motif; other site 749219001500 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 749219001501 tRNA binding surface [nucleotide binding]; other site 749219001502 anticodon binding site; other site 749219001503 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 749219001504 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749219001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219001506 putative substrate translocation pore; other site 749219001507 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 749219001508 HEXXH motif domain; Region: mod_HExxH; TIGR04267 749219001509 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 749219001510 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 749219001511 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 749219001512 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 749219001513 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 749219001514 catalytic residues [active] 749219001515 Ferredoxin [Energy production and conversion]; Region: COG1146 749219001516 4Fe-4S binding domain; Region: Fer4; cl02805 749219001517 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 749219001518 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 749219001519 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 749219001520 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 749219001521 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 749219001522 amidase catalytic site [active] 749219001523 Zn binding residues [ion binding]; other site 749219001524 substrate binding site [chemical binding]; other site 749219001525 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 749219001526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749219001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001528 NAD(P) binding site [chemical binding]; other site 749219001529 active site 749219001530 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 749219001531 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 749219001532 transmembrane helices; other site 749219001533 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 749219001534 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 749219001535 HIGH motif; other site 749219001536 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219001537 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 749219001538 active site 749219001539 KMSKS motif; other site 749219001540 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 749219001541 tRNA binding surface [nucleotide binding]; other site 749219001542 anticodon binding site; other site 749219001543 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 749219001544 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 749219001545 Dam-replacing family; Region: DRP; pfam06044 749219001546 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 749219001547 DNA methylase; Region: N6_N4_Mtase; pfam01555 749219001548 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 749219001549 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 749219001550 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 749219001551 putative active site [active] 749219001552 Zn binding site [ion binding]; other site 749219001553 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 749219001554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219001555 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 749219001556 Walker A/P-loop; other site 749219001557 ATP binding site [chemical binding]; other site 749219001558 Q-loop/lid; other site 749219001559 ABC transporter signature motif; other site 749219001560 Walker B; other site 749219001561 D-loop; other site 749219001562 H-loop/switch region; other site 749219001563 heme exporter protein CcmB; Region: ccmB; TIGR01190 749219001564 nitrilase; Region: PLN02798 749219001565 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 749219001566 putative active site [active] 749219001567 catalytic triad [active] 749219001568 dimer interface [polypeptide binding]; other site 749219001569 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 749219001570 thiS-thiF/thiG interaction site; other site 749219001571 Protein of unknown function (DUF423); Region: DUF423; pfam04241 749219001572 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 749219001573 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749219001574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749219001575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749219001576 DNA binding residues [nucleotide binding] 749219001577 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 749219001578 CPxP motif; other site 749219001579 YcxB-like protein; Region: YcxB; pfam14317 749219001580 seryl-tRNA synthetase; Provisional; Region: PRK05431 749219001581 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 749219001582 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 749219001583 dimer interface [polypeptide binding]; other site 749219001584 active site 749219001585 motif 1; other site 749219001586 motif 2; other site 749219001587 motif 3; other site 749219001588 transketolase; Reviewed; Region: PRK12753 749219001589 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 749219001590 TPP-binding site [chemical binding]; other site 749219001591 dimer interface [polypeptide binding]; other site 749219001592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749219001593 PYR/PP interface [polypeptide binding]; other site 749219001594 dimer interface [polypeptide binding]; other site 749219001595 TPP binding site [chemical binding]; other site 749219001596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749219001597 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 749219001598 putative nucleotide binding site [chemical binding]; other site 749219001599 uridine monophosphate binding site [chemical binding]; other site 749219001600 homohexameric interface [polypeptide binding]; other site 749219001601 ribosome recycling factor; Reviewed; Region: frr; PRK00083 749219001602 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 749219001603 hinge region; other site 749219001604 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 749219001605 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 749219001606 catalytic residue [active] 749219001607 putative FPP diphosphate binding site; other site 749219001608 putative FPP binding hydrophobic cleft; other site 749219001609 dimer interface [polypeptide binding]; other site 749219001610 putative IPP diphosphate binding site; other site 749219001611 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 749219001612 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 749219001613 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 749219001614 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 749219001615 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 749219001616 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 749219001617 zinc metallopeptidase RseP; Provisional; Region: PRK10779 749219001618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 749219001619 active site 749219001620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 749219001621 protein binding site [polypeptide binding]; other site 749219001622 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 749219001623 protein binding site [polypeptide binding]; other site 749219001624 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 749219001625 putative substrate binding region [chemical binding]; other site 749219001626 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 749219001627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 749219001628 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 749219001629 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 749219001630 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 749219001631 Surface antigen; Region: Bac_surface_Ag; pfam01103 749219001632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 749219001633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 749219001634 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 749219001635 trimer interface [polypeptide binding]; other site 749219001636 active site 749219001637 UDP-GlcNAc binding site [chemical binding]; other site 749219001638 lipid binding site [chemical binding]; lipid-binding site 749219001639 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 749219001640 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 749219001641 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 749219001642 active site 749219001643 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 749219001644 Na2 binding site [ion binding]; other site 749219001645 putative substrate binding site 1 [chemical binding]; other site 749219001646 Na binding site 1 [ion binding]; other site 749219001647 putative substrate binding site 2 [chemical binding]; other site 749219001648 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 749219001649 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 749219001650 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 749219001651 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 749219001652 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 749219001653 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 749219001654 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219001655 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749219001656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 749219001657 NAD(P) binding site [chemical binding]; other site 749219001658 catalytic residues [active] 749219001659 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 749219001660 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 749219001661 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 749219001662 Repair protein; Region: Repair_PSII; pfam04536 749219001663 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 749219001664 Repair protein; Region: Repair_PSII; cl01535 749219001665 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749219001666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749219001667 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 749219001668 active site 749219001669 NTP binding site [chemical binding]; other site 749219001670 metal binding triad [ion binding]; metal-binding site 749219001671 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 749219001672 dimer interface [polypeptide binding]; other site 749219001673 FMN binding site [chemical binding]; other site 749219001674 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 749219001675 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 749219001676 active site 749219001677 FMN binding site [chemical binding]; other site 749219001678 substrate binding site [chemical binding]; other site 749219001679 homotetramer interface [polypeptide binding]; other site 749219001680 catalytic residue [active] 749219001681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219001682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219001683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219001684 dimerization interface [polypeptide binding]; other site 749219001685 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 749219001686 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 749219001687 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 749219001688 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 749219001689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 749219001690 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749219001691 Domain of unknown function DUF20; Region: UPF0118; pfam01594 749219001692 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 749219001693 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 749219001694 dimerization interface [polypeptide binding]; other site 749219001695 putative ATP binding site [chemical binding]; other site 749219001696 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 749219001697 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 749219001698 active site 749219001699 substrate binding site [chemical binding]; other site 749219001700 cosubstrate binding site; other site 749219001701 catalytic site [active] 749219001702 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 749219001703 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 749219001704 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 749219001705 HopJ type III effector protein; Region: HopJ; pfam08888 749219001706 carbon storage regulator; Provisional; Region: PRK01712 749219001707 aspartate kinase; Reviewed; Region: PRK06635 749219001708 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 749219001709 putative nucleotide binding site [chemical binding]; other site 749219001710 putative catalytic residues [active] 749219001711 putative Mg ion binding site [ion binding]; other site 749219001712 putative aspartate binding site [chemical binding]; other site 749219001713 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 749219001714 putative allosteric regulatory site; other site 749219001715 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 749219001716 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 749219001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219001718 putative substrate translocation pore; other site 749219001719 POT family; Region: PTR2; cl17359 749219001720 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 749219001721 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 749219001722 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 749219001723 motif 1; other site 749219001724 active site 749219001725 motif 2; other site 749219001726 motif 3; other site 749219001727 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 749219001728 basic region leucin zipper; Region: BRLZ; smart00338 749219001729 DHHA1 domain; Region: DHHA1; pfam02272 749219001730 adenylosuccinate lyase; Provisional; Region: PRK09285 749219001731 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 749219001732 tetramer interface [polypeptide binding]; other site 749219001733 active site 749219001734 Uncharacterized membrane protein [Function unknown]; Region: COG3949 749219001735 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 749219001736 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 749219001737 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 749219001738 homotrimer interaction site [polypeptide binding]; other site 749219001739 zinc binding site [ion binding]; other site 749219001740 CDP-binding sites; other site 749219001741 Isochorismatase family; Region: Isochorismatase; pfam00857 749219001742 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 749219001743 catalytic triad [active] 749219001744 conserved cis-peptide bond; other site 749219001745 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 749219001746 putative GSH binding site [chemical binding]; other site 749219001747 catalytic residues [active] 749219001748 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 749219001749 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219001750 catalytic loop [active] 749219001751 iron binding site [ion binding]; other site 749219001752 chaperone protein HscA; Provisional; Region: hscA; PRK05183 749219001753 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 749219001754 nucleotide binding site [chemical binding]; other site 749219001755 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749219001756 SBD interface [polypeptide binding]; other site 749219001757 co-chaperone HscB; Provisional; Region: hscB; PRK05014 749219001758 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219001759 HSP70 interaction site [polypeptide binding]; other site 749219001760 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 749219001761 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 749219001762 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 749219001763 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 749219001764 trimerization site [polypeptide binding]; other site 749219001765 active site 749219001766 cysteine desulfurase; Provisional; Region: PRK14012 749219001767 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 749219001768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219001769 catalytic residue [active] 749219001770 Transcriptional regulator; Region: Rrf2; cl17282 749219001771 Rrf2 family protein; Region: rrf2_super; TIGR00738 749219001772 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219001773 IHF dimer interface [polypeptide binding]; other site 749219001774 IHF - DNA interface [nucleotide binding]; other site 749219001775 SurA N-terminal domain; Region: SurA_N_3; cl07813 749219001776 periplasmic folding chaperone; Provisional; Region: PRK10788 749219001777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 749219001778 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 749219001779 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 749219001780 purine monophosphate binding site [chemical binding]; other site 749219001781 dimer interface [polypeptide binding]; other site 749219001782 putative catalytic residues [active] 749219001783 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 749219001784 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 749219001785 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 749219001786 trimer interface [polypeptide binding]; other site 749219001787 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 749219001788 trimer interface [polypeptide binding]; other site 749219001789 YadA-like C-terminal region; Region: YadA; pfam03895 749219001790 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 749219001791 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 749219001792 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749219001793 active site 749219001794 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749219001795 Autotransporter beta-domain; Region: Autotransporter; smart00869 749219001796 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 749219001797 Transglycosylase; Region: Transgly; pfam00912 749219001798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749219001799 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 749219001800 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749219001801 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219001802 metal-binding site [ion binding] 749219001803 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749219001804 Soluble P-type ATPase [General function prediction only]; Region: COG4087 749219001805 Bax inhibitor 1 like; Region: BaxI_1; cl17691 749219001806 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 749219001807 ATP-NAD kinase; Region: NAD_kinase; pfam01513 749219001808 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 749219001809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219001810 active site 749219001811 ABC1 family; Region: ABC1; cl17513 749219001812 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 749219001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 749219001814 SCP-2 sterol transfer family; Region: SCP2; pfam02036 749219001815 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 749219001816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001817 S-adenosylmethionine binding site [chemical binding]; other site 749219001818 superoxide dismutase; Provisional; Region: PRK10925 749219001819 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 749219001820 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 749219001821 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 749219001822 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 749219001823 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 749219001824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001825 Walker A motif; other site 749219001826 ATP binding site [chemical binding]; other site 749219001827 Walker B motif; other site 749219001828 Predicted metalloprotease [General function prediction only]; Region: COG2321 749219001829 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 749219001830 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 749219001831 putative hydrolase; Provisional; Region: PRK11460 749219001832 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 749219001833 Transposase IS200 like; Region: Y1_Tnp; pfam01797 749219001834 BON domain; Region: BON; pfam04972 749219001835 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219001836 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 749219001837 NlpE N-terminal domain; Region: NlpE; pfam04170 749219001838 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 749219001839 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749219001840 FtsX-like permease family; Region: FtsX; pfam02687 749219001841 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 749219001842 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749219001843 Walker A/P-loop; other site 749219001844 ATP binding site [chemical binding]; other site 749219001845 Q-loop/lid; other site 749219001846 ABC transporter signature motif; other site 749219001847 Walker B; other site 749219001848 D-loop; other site 749219001849 H-loop/switch region; other site 749219001850 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 749219001851 S-adenosylmethionine synthetase; Validated; Region: PRK05250 749219001852 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 749219001853 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 749219001854 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 749219001855 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 749219001856 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 749219001857 catalytic site [active] 749219001858 putative active site [active] 749219001859 putative substrate binding site [chemical binding]; other site 749219001860 dimer interface [polypeptide binding]; other site 749219001861 Uncharacterized conserved protein [Function unknown]; Region: COG2353 749219001862 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 749219001863 putative active site [active] 749219001864 putative metal binding site [ion binding]; other site 749219001865 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 749219001866 substrate binding site [chemical binding]; other site 749219001867 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 749219001868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001869 active site 749219001870 HIGH motif; other site 749219001871 nucleotide binding site [chemical binding]; other site 749219001872 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 749219001873 KMSKS motif; other site 749219001874 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 749219001875 PIF1-like helicase; Region: PIF1; pfam05970 749219001876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001877 Walker A motif; other site 749219001878 ATP binding site [chemical binding]; other site 749219001879 Walker B motif; other site 749219001880 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 749219001881 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 749219001882 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 749219001883 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 749219001884 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 749219001885 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 749219001886 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 749219001887 peptide chain release factor 2; Validated; Region: prfB; PRK00578 749219001888 This domain is found in peptide chain release factors; Region: PCRF; smart00937 749219001889 RF-1 domain; Region: RF-1; pfam00472 749219001890 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 749219001891 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 749219001892 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 749219001893 Site-specific recombinase; Region: SpecificRecomb; pfam10136 749219001894 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 749219001895 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 749219001896 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749219001897 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 749219001898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749219001899 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749219001900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749219001901 DNA binding residues [nucleotide binding] 749219001902 LrgA family; Region: LrgA; cl00608 749219001903 LrgB-like family; Region: LrgB; cl00596 749219001904 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 749219001905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749219001906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219001907 catalytic residue [active] 749219001908 heat shock protein HtpX; Provisional; Region: PRK05457 749219001909 GTPase HflX; Provisional; Region: PRK11058 749219001910 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 749219001911 HflX GTPase family; Region: HflX; cd01878 749219001912 G1 box; other site 749219001913 GTP/Mg2+ binding site [chemical binding]; other site 749219001914 Switch I region; other site 749219001915 G2 box; other site 749219001916 G3 box; other site 749219001917 Switch II region; other site 749219001918 G4 box; other site 749219001919 G5 box; other site 749219001920 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749219001921 dihydropteroate synthase; Region: DHPS; TIGR01496 749219001922 substrate binding pocket [chemical binding]; other site 749219001923 dimer interface [polypeptide binding]; other site 749219001924 inhibitor binding site; inhibition site 749219001925 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 749219001926 RNA methyltransferase, RsmE family; Region: TIGR00046 749219001927 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 749219001928 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 749219001929 catalytic residues [active] 749219001930 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 749219001931 methionine sulfoxide reductase B; Provisional; Region: PRK00222 749219001932 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 749219001933 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 749219001934 homotetramer interface [polypeptide binding]; other site 749219001935 ligand binding site [chemical binding]; other site 749219001936 catalytic site [active] 749219001937 NAD binding site [chemical binding]; other site 749219001938 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 749219001939 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219001940 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219001941 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 749219001942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219001943 TPR motif; other site 749219001944 Tetratricopeptide repeat; Region: TPR_16; pfam13432 749219001945 binding surface 749219001946 Protein of unknown function (DUF560); Region: DUF560; pfam04575 749219001947 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219001948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 749219001949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219001950 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 749219001951 active site 749219001952 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 749219001953 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219001954 FMN binding site [chemical binding]; other site 749219001955 active site 749219001956 catalytic residues [active] 749219001957 substrate binding site [chemical binding]; other site 749219001958 CAAX protease self-immunity; Region: Abi; pfam02517 749219001959 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749219001960 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 749219001961 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 749219001962 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 749219001963 active site 749219001964 substrate binding site [chemical binding]; other site 749219001965 metal binding site [ion binding]; metal-binding site 749219001966 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 749219001967 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749219001968 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 749219001969 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 749219001970 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 749219001971 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219001972 metal-binding site [ion binding] 749219001973 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 749219001974 NADH dehydrogenase subunit B; Validated; Region: PRK06411 749219001975 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 749219001976 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 749219001977 NADH dehydrogenase subunit D; Validated; Region: PRK06075 749219001978 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749219001979 NADH dehydrogenase subunit E; Validated; Region: PRK07539 749219001980 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 749219001981 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 749219001982 putative dimer interface [polypeptide binding]; other site 749219001983 [2Fe-2S] cluster binding site [ion binding]; other site 749219001984 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 749219001985 SLBB domain; Region: SLBB; pfam10531 749219001986 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 749219001987 NADH dehydrogenase subunit G; Validated; Region: PRK08166 749219001988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219001989 catalytic loop [active] 749219001990 iron binding site [ion binding]; other site 749219001991 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 749219001992 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 749219001993 [4Fe-4S] binding site [ion binding]; other site 749219001994 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 749219001995 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 749219001996 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 749219001997 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 749219001998 4Fe-4S binding domain; Region: Fer4; pfam00037 749219001999 4Fe-4S binding domain; Region: Fer4; pfam00037 749219002000 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 749219002001 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 749219002002 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 749219002003 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 749219002004 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 749219002005 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749219002006 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 749219002007 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749219002008 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 749219002009 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749219002010 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 749219002011 catalytic triad [active] 749219002012 dimer interface [polypeptide binding]; other site 749219002013 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219002014 ferredoxin-NADP reductase; Provisional; Region: PRK10926 749219002015 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 749219002016 FAD binding pocket [chemical binding]; other site 749219002017 FAD binding motif [chemical binding]; other site 749219002018 phosphate binding motif [ion binding]; other site 749219002019 beta-alpha-beta structure motif; other site 749219002020 NAD binding pocket [chemical binding]; other site 749219002021 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 749219002022 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 749219002023 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 749219002024 active site 749219002025 HIGH motif; other site 749219002026 KMSK motif region; other site 749219002027 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 749219002028 tRNA binding surface [nucleotide binding]; other site 749219002029 anticodon binding site; other site 749219002030 Uncharacterized conserved protein [Function unknown]; Region: COG1434 749219002031 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 749219002032 putative active site [active] 749219002033 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 749219002034 FAD binding domain; Region: FAD_binding_4; pfam01565 749219002035 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 749219002036 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 749219002037 Low molecular weight phosphatase family; Region: LMWPc; cd00115 749219002038 active site 749219002039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219002040 RNA binding surface [nucleotide binding]; other site 749219002041 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 749219002042 threonine dehydratase; Reviewed; Region: PRK09224 749219002043 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 749219002044 tetramer interface [polypeptide binding]; other site 749219002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219002046 catalytic residue [active] 749219002047 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 749219002048 putative Ile/Val binding site [chemical binding]; other site 749219002049 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 749219002050 putative Ile/Val binding site [chemical binding]; other site 749219002051 hypothetical protein; Validated; Region: PRK00110 749219002052 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 749219002053 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749219002054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219002055 FeS/SAM binding site; other site 749219002056 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 749219002057 Coenzyme A transferase; Region: CoA_trans; cl17247 749219002058 Coenzyme A transferase; Region: CoA_trans; cl17247 749219002059 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 749219002060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 749219002061 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 749219002062 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 749219002063 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 749219002064 Ligand Binding Site [chemical binding]; other site 749219002065 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219002066 active site residue [active] 749219002067 potential frameshift: common BLAST hit: gi|148652574|ref|YP_001279667.1| NnrS family protein 749219002068 NnrS protein; Region: NnrS; pfam05940 749219002069 NnrS protein; Region: NnrS; pfam05940 749219002070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749219002071 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 749219002072 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 749219002073 putative switch regulator; other site 749219002074 non-specific DNA interactions [nucleotide binding]; other site 749219002075 DNA binding site [nucleotide binding] 749219002076 sequence specific DNA binding site [nucleotide binding]; other site 749219002077 putative cAMP binding site [chemical binding]; other site 749219002078 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 749219002079 active site clefts [active] 749219002080 zinc binding site [ion binding]; other site 749219002081 dimer interface [polypeptide binding]; other site 749219002082 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 749219002083 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 749219002084 [4Fe-4S] binding site [ion binding]; other site 749219002085 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219002086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219002087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219002088 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 749219002089 molybdopterin cofactor binding site; other site 749219002090 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 749219002091 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 749219002092 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 749219002093 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 749219002094 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 749219002095 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 749219002096 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 749219002097 dimer interface [polypeptide binding]; other site 749219002098 putative functional site; other site 749219002099 putative MPT binding site; other site 749219002100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002101 Walker A/P-loop; other site 749219002102 ATP binding site [chemical binding]; other site 749219002103 Q-loop/lid; other site 749219002104 ABC transporter signature motif; other site 749219002105 Walker B; other site 749219002106 D-loop; other site 749219002107 H-loop/switch region; other site 749219002108 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 749219002109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002110 dimer interface [polypeptide binding]; other site 749219002111 conserved gate region; other site 749219002112 putative PBP binding loops; other site 749219002113 ABC-ATPase subunit interface; other site 749219002114 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 749219002115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 749219002116 TOBE domain; Region: TOBE; cl01440 749219002117 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 749219002118 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 749219002119 MoaE homodimer interface [polypeptide binding]; other site 749219002120 MoaD interaction [polypeptide binding]; other site 749219002121 active site residues [active] 749219002122 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 749219002123 MoaE interaction surface [polypeptide binding]; other site 749219002124 MoeB interaction surface [polypeptide binding]; other site 749219002125 thiocarboxylated glycine; other site 749219002126 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 749219002127 trimer interface [polypeptide binding]; other site 749219002128 dimer interface [polypeptide binding]; other site 749219002129 putative active site [active] 749219002130 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 749219002131 GTP binding site; other site 749219002132 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 749219002133 MPT binding site; other site 749219002134 trimer interface [polypeptide binding]; other site 749219002135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 749219002136 MOSC domain; Region: MOSC; pfam03473 749219002137 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 749219002138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219002139 FeS/SAM binding site; other site 749219002140 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 749219002141 transcriptional regulator NarL; Provisional; Region: PRK10651 749219002142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219002143 active site 749219002144 phosphorylation site [posttranslational modification] 749219002145 intermolecular recognition site; other site 749219002146 dimerization interface [polypeptide binding]; other site 749219002147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749219002148 DNA binding residues [nucleotide binding] 749219002149 dimerization interface [polypeptide binding]; other site 749219002150 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 749219002151 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 749219002152 HAMP domain; Region: HAMP; pfam00672 749219002153 Histidine kinase; Region: HisKA_3; pfam07730 749219002154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219002155 ATP binding site [chemical binding]; other site 749219002156 Mg2+ binding site [ion binding]; other site 749219002157 G-X-G motif; other site 749219002158 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 749219002159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219002160 putative substrate translocation pore; other site 749219002161 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 749219002162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 749219002163 putative substrate translocation pore; other site 749219002164 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 749219002165 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 749219002166 ATP binding site [chemical binding]; other site 749219002167 substrate interface [chemical binding]; other site 749219002168 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002169 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002170 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002171 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002172 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 749219002173 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 749219002174 potential catalytic triad [active] 749219002175 conserved cys residue [active] 749219002176 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749219002177 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 749219002178 succinic semialdehyde dehydrogenase; Region: PLN02278 749219002179 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 749219002180 tetramerization interface [polypeptide binding]; other site 749219002181 NAD(P) binding site [chemical binding]; other site 749219002182 catalytic residues [active] 749219002183 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 749219002184 peptide chain release factor 1; Validated; Region: prfA; PRK00591 749219002185 This domain is found in peptide chain release factors; Region: PCRF; smart00937 749219002186 RF-1 domain; Region: RF-1; pfam00472 749219002187 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 749219002188 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 749219002189 dimerization interface [polypeptide binding]; other site 749219002190 active site 749219002191 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 749219002192 quinolinate synthetase; Provisional; Region: PRK09375 749219002193 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 749219002194 L-aspartate oxidase; Provisional; Region: PRK06175 749219002195 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749219002196 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 749219002197 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 749219002198 TolR protein; Region: tolR; TIGR02801 749219002199 Intracellular septation protein A; Region: IspA; pfam04279 749219002200 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 749219002201 Found in ATP-dependent protease La (LON); Region: LON; smart00464 749219002202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002203 Walker A motif; other site 749219002204 ATP binding site [chemical binding]; other site 749219002205 Walker B motif; other site 749219002206 arginine finger; other site 749219002207 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 749219002208 Predicted permease [General function prediction only]; Region: COG2056 749219002209 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 749219002210 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 749219002211 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 749219002212 TrkA-N domain; Region: TrkA_N; pfam02254 749219002213 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 749219002214 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 749219002215 oligomer interface [polypeptide binding]; other site 749219002216 metal binding site [ion binding]; metal-binding site 749219002217 metal binding site [ion binding]; metal-binding site 749219002218 putative Cl binding site [ion binding]; other site 749219002219 basic sphincter; other site 749219002220 hydrophobic gate; other site 749219002221 periplasmic entrance; other site 749219002222 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 749219002223 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 749219002224 dimer interface [polypeptide binding]; other site 749219002225 motif 1; other site 749219002226 active site 749219002227 motif 2; other site 749219002228 motif 3; other site 749219002229 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 749219002230 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 749219002231 GDP-binding site [chemical binding]; other site 749219002232 ACT binding site; other site 749219002233 IMP binding site; other site 749219002234 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 749219002235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 749219002236 Zn binding site [ion binding]; other site 749219002237 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749219002238 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749219002239 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 749219002240 heme binding pocket [chemical binding]; other site 749219002241 heme ligand [chemical binding]; other site 749219002242 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 749219002243 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749219002244 minor groove reading motif; other site 749219002245 helix-hairpin-helix signature motif; other site 749219002246 substrate binding pocket [chemical binding]; other site 749219002247 active site 749219002248 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 749219002249 AAA domain; Region: AAA_32; pfam13654 749219002250 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 749219002251 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 749219002252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219002253 S-adenosylmethionine binding site [chemical binding]; other site 749219002254 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749219002255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749219002256 Magnesium ion binding site [ion binding]; other site 749219002257 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 749219002258 ParB-like nuclease domain; Region: ParBc; pfam02195 749219002259 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 749219002260 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 749219002261 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 749219002262 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 749219002263 Ligand binding site; other site 749219002264 oligomer interface; other site 749219002265 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749219002266 catalytic core [active] 749219002267 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 749219002268 DNA polymerase III subunit delta'; Validated; Region: PRK08485 749219002269 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 749219002270 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749219002271 phosphate binding site [ion binding]; other site 749219002272 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 749219002273 L-lactate permease; Region: Lactate_perm; cl00701 749219002274 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 749219002275 putative active site [active] 749219002276 putative catalytic site [active] 749219002277 putative DNA binding site [nucleotide binding]; other site 749219002278 putative phosphate binding site [ion binding]; other site 749219002279 metal binding site A [ion binding]; metal-binding site 749219002280 putative AP binding site [nucleotide binding]; other site 749219002281 putative metal binding site B [ion binding]; other site 749219002282 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 749219002283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749219002284 GTP-binding protein YchF; Reviewed; Region: PRK09601 749219002285 YchF GTPase; Region: YchF; cd01900 749219002286 G1 box; other site 749219002287 GTP/Mg2+ binding site [chemical binding]; other site 749219002288 Switch I region; other site 749219002289 G2 box; other site 749219002290 Switch II region; other site 749219002291 G3 box; other site 749219002292 G4 box; other site 749219002293 G5 box; other site 749219002294 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 749219002295 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 749219002296 active site 749219002297 multimer interface [polypeptide binding]; other site 749219002298 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 749219002299 Predicted ATPase [General function prediction only]; Region: COG1485 749219002300 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 749219002301 putative FMN binding site [chemical binding]; other site 749219002302 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 749219002303 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 749219002304 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 749219002305 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 749219002306 catalytic core [active] 749219002307 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 749219002308 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 749219002309 PhoH-like protein; Region: PhoH; pfam02562 749219002310 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 749219002311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219002312 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749219002313 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 749219002314 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749219002315 carboxyltransferase (CT) interaction site; other site 749219002316 biotinylation site [posttranslational modification]; other site 749219002317 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 749219002318 ribonuclease D; Region: rnd; TIGR01388 749219002319 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 749219002320 catalytic site [active] 749219002321 putative active site [active] 749219002322 putative substrate binding site [chemical binding]; other site 749219002323 HRDC domain; Region: HRDC; pfam00570 749219002324 recombination protein RecR; Reviewed; Region: recR; PRK00076 749219002325 RecR protein; Region: RecR; pfam02132 749219002326 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 749219002327 putative active site [active] 749219002328 putative metal-binding site [ion binding]; other site 749219002329 tetramer interface [polypeptide binding]; other site 749219002330 hypothetical protein; Validated; Region: PRK00153 749219002331 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 749219002332 ATP cone domain; Region: ATP-cone; pfam03477 749219002333 Class I ribonucleotide reductase; Region: RNR_I; cd01679 749219002334 active site 749219002335 dimer interface [polypeptide binding]; other site 749219002336 catalytic residues [active] 749219002337 effector binding site; other site 749219002338 R2 peptide binding site; other site 749219002339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 749219002340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 749219002341 RNA binding surface [nucleotide binding]; other site 749219002342 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 749219002343 probable active site [active] 749219002344 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 749219002345 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 749219002346 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 749219002347 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 749219002348 active site 749219002349 HIGH motif; other site 749219002350 dimer interface [polypeptide binding]; other site 749219002351 KMSKS motif; other site 749219002352 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 749219002353 active site 749219002354 ribulose/triose binding site [chemical binding]; other site 749219002355 phosphate binding site [ion binding]; other site 749219002356 substrate (anthranilate) binding pocket [chemical binding]; other site 749219002357 product (indole) binding pocket [chemical binding]; other site 749219002358 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 749219002359 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 749219002360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 749219002361 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 749219002362 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 749219002363 glutamine binding [chemical binding]; other site 749219002364 catalytic triad [active] 749219002365 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 749219002366 tetramerization interface [polypeptide binding]; other site 749219002367 active site 749219002368 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 749219002369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 749219002370 putative acyl-acceptor binding pocket; other site 749219002371 ABC transporter ATPase component; Reviewed; Region: PRK11147 749219002372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002373 Walker A/P-loop; other site 749219002374 ATP binding site [chemical binding]; other site 749219002375 Q-loop/lid; other site 749219002376 ABC transporter signature motif; other site 749219002377 Walker B; other site 749219002378 D-loop; other site 749219002379 H-loop/switch region; other site 749219002380 ABC transporter; Region: ABC_tran_2; pfam12848 749219002381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219002382 SlyX; Region: SlyX; pfam04102 749219002383 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 749219002384 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749219002385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749219002386 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749219002387 ornithine carbamoyltransferase; Provisional; Region: PRK00779 749219002388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749219002389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 749219002390 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 749219002391 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749219002392 dimer interface [polypeptide binding]; other site 749219002393 active site 749219002394 CoA binding pocket [chemical binding]; other site 749219002395 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 749219002396 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 749219002397 ligand binding site [chemical binding]; other site 749219002398 active site 749219002399 UGI interface [polypeptide binding]; other site 749219002400 catalytic site [active] 749219002401 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749219002402 nucleoside/Zn binding site; other site 749219002403 dimer interface [polypeptide binding]; other site 749219002404 catalytic motif [active] 749219002405 cytidylate kinase; Provisional; Region: cmk; PRK00023 749219002406 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 749219002407 CMP-binding site; other site 749219002408 The sites determining sugar specificity; other site 749219002409 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 749219002410 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 749219002411 RNA binding site [nucleotide binding]; other site 749219002412 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 749219002413 RNA binding site [nucleotide binding]; other site 749219002414 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 749219002415 RNA binding site [nucleotide binding]; other site 749219002416 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 749219002417 RNA binding site [nucleotide binding]; other site 749219002418 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 749219002419 RNA binding site [nucleotide binding]; other site 749219002420 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 749219002421 RNA binding site [nucleotide binding]; other site 749219002422 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219002423 IHF dimer interface [polypeptide binding]; other site 749219002424 IHF - DNA interface [nucleotide binding]; other site 749219002425 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 749219002426 active site 749219002427 dimer interface [polypeptide binding]; other site 749219002428 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 749219002429 Ligand Binding Site [chemical binding]; other site 749219002430 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 749219002431 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 749219002432 Uncharacterized conserved protein [Function unknown]; Region: COG4121 749219002433 YciI-like protein; Reviewed; Region: PRK11370 749219002434 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 749219002435 ferredoxin; Provisional; Region: PRK08764 749219002436 Putative Fe-S cluster; Region: FeS; cl17515 749219002437 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 749219002438 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 749219002439 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 749219002440 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 749219002441 putative NADH binding site [chemical binding]; other site 749219002442 putative active site [active] 749219002443 nudix motif; other site 749219002444 putative metal binding site [ion binding]; other site 749219002445 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 749219002446 RNA/DNA hybrid binding site [nucleotide binding]; other site 749219002447 active site 749219002448 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 749219002449 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 749219002450 active site 749219002451 catalytic site [active] 749219002452 substrate binding site [chemical binding]; other site 749219002453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219002454 S-adenosylmethionine binding site [chemical binding]; other site 749219002455 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 749219002456 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 749219002457 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 749219002458 ABC1 family; Region: ABC1; pfam03109 749219002459 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 749219002460 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 749219002461 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 749219002462 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 749219002463 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749219002464 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749219002465 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749219002466 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 749219002467 Serine hydrolase (FSH1); Region: FSH1; pfam03959 749219002468 Rubredoxin [Energy production and conversion]; Region: COG1773 749219002469 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 749219002470 iron binding site [ion binding]; other site 749219002471 Chorismate mutase type II; Region: CM_2; cl00693 749219002472 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 749219002473 Prephenate dehydratase; Region: PDT; pfam00800 749219002474 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 749219002475 putative L-Phe binding site [chemical binding]; other site 749219002476 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 749219002477 prephenate dehydrogenase; Validated; Region: PRK08507 749219002478 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 749219002479 hinge; other site 749219002480 active site 749219002481 Predicted permeases [General function prediction only]; Region: RarD; COG2962 749219002482 Dihydroneopterin aldolase; Region: FolB; pfam02152 749219002483 active site 749219002484 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 749219002485 catalytic center binding site [active] 749219002486 ATP binding site [chemical binding]; other site 749219002487 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 749219002488 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 749219002489 dimer interface [polypeptide binding]; other site 749219002490 TPP-binding site [chemical binding]; other site 749219002491 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 749219002492 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219002493 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 749219002494 E3 interaction surface; other site 749219002495 lipoyl attachment site [posttranslational modification]; other site 749219002496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219002497 E3 interaction surface; other site 749219002498 lipoyl attachment site [posttranslational modification]; other site 749219002499 e3 binding domain; Region: E3_binding; pfam02817 749219002500 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749219002501 putative S-transferase; Provisional; Region: PRK11752 749219002502 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 749219002503 C-terminal domain interface [polypeptide binding]; other site 749219002504 GSH binding site (G-site) [chemical binding]; other site 749219002505 dimer interface [polypeptide binding]; other site 749219002506 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 749219002507 dimer interface [polypeptide binding]; other site 749219002508 N-terminal domain interface [polypeptide binding]; other site 749219002509 active site 749219002510 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 749219002511 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 749219002512 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 749219002513 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 749219002514 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 749219002515 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749219002516 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 749219002517 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 749219002518 homodimer interface [polypeptide binding]; other site 749219002519 substrate-cofactor binding pocket; other site 749219002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219002521 catalytic residue [active] 749219002522 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 749219002523 dimer interface [polypeptide binding]; other site 749219002524 putative radical transfer pathway; other site 749219002525 diiron center [ion binding]; other site 749219002526 tyrosyl radical; other site 749219002527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219002528 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 749219002529 catalytic loop [active] 749219002530 iron binding site [ion binding]; other site 749219002531 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 749219002532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 749219002533 dimer interface [polypeptide binding]; other site 749219002534 active site 749219002535 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219002536 catalytic residues [active] 749219002537 substrate binding site [chemical binding]; other site 749219002538 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 749219002539 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 749219002540 NAD(P) binding pocket [chemical binding]; other site 749219002541 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 749219002542 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 749219002543 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 749219002544 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 749219002545 bacterial Hfq-like; Region: Hfq; cd01716 749219002546 hexamer interface [polypeptide binding]; other site 749219002547 Sm1 motif; other site 749219002548 RNA binding site [nucleotide binding]; other site 749219002549 Sm2 motif; other site 749219002550 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 749219002551 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 749219002552 putative active site [active] 749219002553 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 749219002554 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 749219002555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219002556 active site 749219002557 motif I; other site 749219002558 motif II; other site 749219002559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 749219002560 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 749219002561 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 749219002562 OstA-like protein; Region: OstA; pfam03968 749219002563 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 749219002564 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 749219002565 Walker A/P-loop; other site 749219002566 ATP binding site [chemical binding]; other site 749219002567 Q-loop/lid; other site 749219002568 ABC transporter signature motif; other site 749219002569 Walker B; other site 749219002570 D-loop; other site 749219002571 H-loop/switch region; other site 749219002572 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 749219002573 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 749219002574 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 749219002575 Glutamate binding site [chemical binding]; other site 749219002576 NAD binding site [chemical binding]; other site 749219002577 catalytic residues [active] 749219002578 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 749219002579 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749219002580 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749219002581 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219002582 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749219002583 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749219002584 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219002585 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 749219002586 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 749219002587 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 749219002588 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 749219002589 P loop; other site 749219002590 GTP binding site [chemical binding]; other site 749219002591 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749219002592 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749219002593 DNA binding site [nucleotide binding] 749219002594 active site 749219002595 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 749219002596 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 749219002597 quinone interaction residues [chemical binding]; other site 749219002598 active site 749219002599 catalytic residues [active] 749219002600 FMN binding site [chemical binding]; other site 749219002601 substrate binding site [chemical binding]; other site 749219002602 Colicin V production protein; Region: Colicin_V; pfam02674 749219002603 amidophosphoribosyltransferase; Provisional; Region: PRK09246 749219002604 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 749219002605 active site 749219002606 tetramer interface [polypeptide binding]; other site 749219002607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219002608 active site 749219002609 Transglycosylase SLT domain; Region: SLT_2; pfam13406 749219002610 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749219002611 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219002612 catalytic residue [active] 749219002613 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749219002614 excinuclease ABC subunit B; Provisional; Region: PRK05298 749219002615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002616 ATP binding site [chemical binding]; other site 749219002617 putative Mg++ binding site [ion binding]; other site 749219002618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002619 nucleotide binding region [chemical binding]; other site 749219002620 ATP-binding site [chemical binding]; other site 749219002621 Ultra-violet resistance protein B; Region: UvrB; pfam12344 749219002622 UvrB/uvrC motif; Region: UVR; pfam02151 749219002623 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 749219002624 putative active site [active] 749219002625 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 749219002626 Family description; Region: UvrD_C_2; pfam13538 749219002627 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 749219002628 AAA domain; Region: AAA_30; pfam13604 749219002629 AAA domain; Region: AAA_22; pfam13401 749219002630 Family description; Region: UvrD_C_2; pfam13538 749219002631 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749219002632 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 749219002633 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219002634 FMN binding site [chemical binding]; other site 749219002635 active site 749219002636 catalytic residues [active] 749219002637 substrate binding site [chemical binding]; other site 749219002638 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 749219002639 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 749219002640 generic binding surface II; other site 749219002641 generic binding surface I; other site 749219002642 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 749219002643 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 749219002644 Predicted transcriptional regulator [Transcription]; Region: COG2932 749219002645 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 749219002646 Catalytic site [active] 749219002647 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 749219002648 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 749219002649 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 749219002650 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 749219002651 Prophage antirepressor [Transcription]; Region: COG3617 749219002652 BRO family, N-terminal domain; Region: Bro-N; smart01040 749219002653 ORF6C domain; Region: ORF6C; pfam10552 749219002654 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 749219002655 Phage-related protein [Function unknown]; Region: COG5412 749219002656 membrane protein P6; Region: PHA01399 749219002657 Phage minor tail protein L; Region: Phage_tail_L; cl01908 749219002658 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 749219002659 MPN+ (JAMM) motif; other site 749219002660 Zinc-binding site [ion binding]; other site 749219002661 NlpC/P60 family; Region: NLPC_P60; cl17555 749219002662 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749219002663 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 749219002664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 749219002665 alpha-amylase; Region: PLN02361 749219002666 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749219002667 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749219002668 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749219002669 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749219002670 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219002671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 749219002672 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 749219002673 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 749219002674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002675 ATP binding site [chemical binding]; other site 749219002676 putative Mg++ binding site [ion binding]; other site 749219002677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002678 nucleotide binding region [chemical binding]; other site 749219002679 ATP-binding site [chemical binding]; other site 749219002680 Helicase associated domain (HA2); Region: HA2; pfam04408 749219002681 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 749219002682 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 749219002683 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 749219002684 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 749219002685 TolR protein; Region: tolR; TIGR02801 749219002686 TolA protein; Region: tolA_full; TIGR02794 749219002687 Gram-negative bacterial tonB protein; Region: TonB; cl10048 749219002688 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 749219002689 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749219002690 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 749219002691 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 749219002692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002693 ATP binding site [chemical binding]; other site 749219002694 putative Mg++ binding site [ion binding]; other site 749219002695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002696 nucleotide binding region [chemical binding]; other site 749219002697 ATP-binding site [chemical binding]; other site 749219002698 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 749219002699 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 749219002700 active site 749219002701 thiamine phosphate binding site [chemical binding]; other site 749219002702 pyrophosphate binding site [ion binding]; other site 749219002703 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 749219002704 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 749219002705 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 749219002706 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 749219002707 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 749219002708 Entericidin EcnA/B family; Region: Entericidin; cl02322 749219002709 HemN family oxidoreductase; Provisional; Region: PRK05660 749219002710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219002711 FeS/SAM binding site; other site 749219002712 HemN C-terminal domain; Region: HemN_C; pfam06969 749219002713 helicase 45; Provisional; Region: PTZ00424 749219002714 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749219002715 ATP binding site [chemical binding]; other site 749219002716 Mg++ binding site [ion binding]; other site 749219002717 motif III; other site 749219002718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002719 nucleotide binding region [chemical binding]; other site 749219002720 ATP-binding site [chemical binding]; other site 749219002721 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 749219002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002723 dimer interface [polypeptide binding]; other site 749219002724 conserved gate region; other site 749219002725 putative PBP binding loops; other site 749219002726 ABC-ATPase subunit interface; other site 749219002727 sulfate transport protein; Provisional; Region: cysT; CHL00187 749219002728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002729 dimer interface [polypeptide binding]; other site 749219002730 conserved gate region; other site 749219002731 putative PBP binding loops; other site 749219002732 ABC-ATPase subunit interface; other site 749219002733 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 749219002734 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 749219002735 Walker A/P-loop; other site 749219002736 ATP binding site [chemical binding]; other site 749219002737 Q-loop/lid; other site 749219002738 ABC transporter signature motif; other site 749219002739 Walker B; other site 749219002740 D-loop; other site 749219002741 H-loop/switch region; other site 749219002742 DNA repair protein RadA; Provisional; Region: PRK11823 749219002743 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749219002744 Walker A motif; other site 749219002745 ATP binding site [chemical binding]; other site 749219002746 Walker B motif; other site 749219002747 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 749219002748 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 749219002749 active site 749219002750 substrate-binding site [chemical binding]; other site 749219002751 metal-binding site [ion binding] 749219002752 GTP binding site [chemical binding]; other site 749219002753 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 749219002754 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749219002755 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219002756 catalytic residue [active] 749219002757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219002758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219002759 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 749219002760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219002761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219002762 Domain of unknown function DUF21; Region: DUF21; pfam01595 749219002763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219002764 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 749219002765 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 749219002766 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 749219002767 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 749219002768 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 749219002769 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 749219002770 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 749219002771 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 749219002772 Protein export membrane protein; Region: SecD_SecF; pfam02355 749219002773 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 749219002774 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 749219002775 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 749219002776 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 749219002777 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 749219002778 dimer interface [polypeptide binding]; other site 749219002779 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 749219002780 active site 749219002781 Fe binding site [ion binding]; other site 749219002782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219002783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219002784 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 749219002785 putative dimerization interface [polypeptide binding]; other site 749219002786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219002787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219002788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219002789 dimerization interface [polypeptide binding]; other site 749219002790 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 749219002791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002792 Walker A motif; other site 749219002793 ATP binding site [chemical binding]; other site 749219002794 Walker B motif; other site 749219002795 arginine finger; other site 749219002796 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 749219002797 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 749219002798 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 749219002799 dimer interface [polypeptide binding]; other site 749219002800 putative anticodon binding site; other site 749219002801 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 749219002802 motif 1; other site 749219002803 active site 749219002804 motif 2; other site 749219002805 motif 3; other site 749219002806 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 749219002807 putative catalytic site [active] 749219002808 putative phosphate binding site [ion binding]; other site 749219002809 active site 749219002810 metal binding site A [ion binding]; metal-binding site 749219002811 DNA binding site [nucleotide binding] 749219002812 putative AP binding site [nucleotide binding]; other site 749219002813 putative metal binding site B [ion binding]; other site 749219002814 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749219002815 active site 749219002816 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 749219002817 tartrate dehydrogenase; Region: TTC; TIGR02089 749219002818 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 749219002819 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 749219002820 substrate binding site [chemical binding]; other site 749219002821 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 749219002822 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 749219002823 substrate binding site [chemical binding]; other site 749219002824 ligand binding site [chemical binding]; other site 749219002825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219002826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219002827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749219002828 dimerization interface [polypeptide binding]; other site 749219002829 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 749219002830 RuvA N terminal domain; Region: RuvA_N; pfam01330 749219002831 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 749219002832 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 749219002833 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 749219002834 intersubunit interface [polypeptide binding]; other site 749219002835 active site 749219002836 zinc binding site [ion binding]; other site 749219002837 Na+ binding site [ion binding]; other site 749219002838 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 749219002839 Phosphoglycerate kinase; Region: PGK; pfam00162 749219002840 substrate binding site [chemical binding]; other site 749219002841 hinge regions; other site 749219002842 ADP binding site [chemical binding]; other site 749219002843 catalytic site [active] 749219002844 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 749219002845 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 749219002846 active site 749219002847 metal binding site [ion binding]; metal-binding site 749219002848 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 749219002849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219002850 S-adenosylmethionine binding site [chemical binding]; other site 749219002851 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 749219002852 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 749219002853 replicative DNA helicase; Region: DnaB; TIGR00665 749219002854 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 749219002855 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 749219002856 Walker A motif; other site 749219002857 ATP binding site [chemical binding]; other site 749219002858 Walker B motif; other site 749219002859 DNA binding loops [nucleotide binding] 749219002860 alanine racemase; Reviewed; Region: alr; PRK00053 749219002861 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 749219002862 active site 749219002863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219002864 substrate binding site [chemical binding]; other site 749219002865 catalytic residues [active] 749219002866 dimer interface [polypeptide binding]; other site 749219002867 MltA-interacting protein MipA; Region: MipA; cl01504 749219002868 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 749219002869 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 749219002870 heme binding site [chemical binding]; other site 749219002871 ferroxidase pore; other site 749219002872 ferroxidase diiron center [ion binding]; other site 749219002873 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 749219002874 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 749219002875 heme binding site [chemical binding]; other site 749219002876 ferroxidase pore; other site 749219002877 ferroxidase diiron center [ion binding]; other site 749219002878 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 749219002879 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 749219002880 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 749219002881 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 749219002882 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 749219002883 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 749219002884 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 749219002885 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 749219002886 homodimer interface [polypeptide binding]; other site 749219002887 NADP binding site [chemical binding]; other site 749219002888 substrate binding site [chemical binding]; other site 749219002889 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 749219002890 Clp amino terminal domain; Region: Clp_N; pfam02861 749219002891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002892 Walker A motif; other site 749219002893 ATP binding site [chemical binding]; other site 749219002894 Walker B motif; other site 749219002895 arginine finger; other site 749219002896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002897 Walker A motif; other site 749219002898 ATP binding site [chemical binding]; other site 749219002899 Walker B motif; other site 749219002900 arginine finger; other site 749219002901 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 749219002902 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 749219002903 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749219002904 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219002905 metal-binding site [ion binding] 749219002906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749219002907 Soluble P-type ATPase [General function prediction only]; Region: COG4087 749219002908 Uncharacterized conserved protein [Function unknown]; Region: COG0327 749219002909 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 749219002910 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 749219002911 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 749219002912 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 749219002913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219002914 RNA binding surface [nucleotide binding]; other site 749219002915 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 749219002916 active site 749219002917 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 749219002918 CHC2 zinc finger; Region: zf-CHC2; pfam01807 749219002919 DNA primase; Validated; Region: dnaG; PRK05667 749219002920 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 749219002921 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 749219002922 active site 749219002923 metal binding site [ion binding]; metal-binding site 749219002924 interdomain interaction site; other site 749219002925 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 749219002926 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 749219002927 putative C-terminal domain interface [polypeptide binding]; other site 749219002928 putative GSH binding site (G-site) [chemical binding]; other site 749219002929 putative dimer interface [polypeptide binding]; other site 749219002930 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 749219002931 N-terminal domain interface [polypeptide binding]; other site 749219002932 dimer interface [polypeptide binding]; other site 749219002933 substrate binding pocket (H-site) [chemical binding]; other site 749219002934 DNA gyrase subunit A; Validated; Region: PRK05560 749219002935 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 749219002936 CAP-like domain; other site 749219002937 active site 749219002938 primary dimer interface [polypeptide binding]; other site 749219002939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002941 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002942 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002944 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002946 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749219002947 NAD(P) binding site [chemical binding]; other site 749219002948 active site 749219002949 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 749219002950 response regulator; Provisional; Region: PRK09483 749219002951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219002952 active site 749219002953 phosphorylation site [posttranslational modification] 749219002954 intermolecular recognition site; other site 749219002955 dimerization interface [polypeptide binding]; other site 749219002956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749219002957 DNA binding residues [nucleotide binding] 749219002958 dimerization interface [polypeptide binding]; other site 749219002959 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 749219002960 C-terminal peptidase (prc); Region: prc; TIGR00225 749219002961 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 749219002962 protein binding site [polypeptide binding]; other site 749219002963 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 749219002964 Catalytic dyad [active] 749219002965 phosphoglyceromutase; Provisional; Region: PRK05434 749219002966 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 749219002967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749219002968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749219002969 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 749219002970 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 749219002971 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 749219002972 catalytic triad [active] 749219002973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749219002974 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749219002975 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 749219002976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002978 Walker A/P-loop; other site 749219002979 Walker A/P-loop; other site 749219002980 ATP binding site [chemical binding]; other site 749219002981 ATP binding site [chemical binding]; other site 749219002982 Q-loop/lid; other site 749219002983 ABC transporter signature motif; other site 749219002984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002985 Walker B; other site 749219002986 Walker B; other site 749219002987 D-loop; other site 749219002988 D-loop; other site 749219002989 H-loop/switch region; other site 749219002990 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 749219002991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749219002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219002993 Walker A/P-loop; other site 749219002994 ATP binding site [chemical binding]; other site 749219002995 Q-loop/lid; other site 749219002996 ABC transporter signature motif; other site 749219002997 Walker B; other site 749219002998 D-loop; other site 749219002999 H-loop/switch region; other site 749219003000 fumarate hydratase; Reviewed; Region: fumC; PRK00485 749219003001 Class II fumarases; Region: Fumarase_classII; cd01362 749219003002 active site 749219003003 tetramer interface [polypeptide binding]; other site 749219003004 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 749219003005 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 749219003006 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 749219003007 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 749219003008 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 749219003009 substrate binding site [chemical binding]; other site 749219003010 hexamer interface [polypeptide binding]; other site 749219003011 metal binding site [ion binding]; metal-binding site 749219003012 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 749219003013 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 749219003014 NAD binding site [chemical binding]; other site 749219003015 homotetramer interface [polypeptide binding]; other site 749219003016 homodimer interface [polypeptide binding]; other site 749219003017 substrate binding site [chemical binding]; other site 749219003018 active site 749219003019 GTP cyclohydrolase I [Coenzyme metabolism]; Region: FolE; COG0302 749219003020 active site 749219003021 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 749219003022 PLD-like domain; Region: PLDc_2; pfam13091 749219003023 putative active site [active] 749219003024 catalytic site [active] 749219003025 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 749219003026 PLD-like domain; Region: PLDc_2; pfam13091 749219003027 putative active site [active] 749219003028 catalytic site [active] 749219003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219003030 putative substrate translocation pore; other site 749219003031 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 749219003032 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749219003033 active site 749219003034 dimer interface [polypeptide binding]; other site 749219003035 Predicted membrane protein [Function unknown]; Region: COG2431 749219003036 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 749219003037 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 749219003038 glutamine synthetase; Provisional; Region: glnA; PRK09469 749219003039 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 749219003040 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749219003041 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749219003042 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 749219003043 putative metal binding site; other site 749219003044 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749219003045 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 749219003046 putative metal binding site; other site 749219003047 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 749219003048 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 749219003049 putative ADP-binding pocket [chemical binding]; other site 749219003050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749219003051 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219003052 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 749219003053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749219003054 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 749219003055 Walker A/P-loop; other site 749219003056 ATP binding site [chemical binding]; other site 749219003057 Q-loop/lid; other site 749219003058 ABC transporter signature motif; other site 749219003059 Walker B; other site 749219003060 D-loop; other site 749219003061 H-loop/switch region; other site 749219003062 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749219003063 DNA-binding site [nucleotide binding]; DNA binding site 749219003064 RNA-binding motif; other site 749219003065 Dehydroquinase class II; Region: DHquinase_II; pfam01220 749219003066 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 749219003067 trimer interface [polypeptide binding]; other site 749219003068 active site 749219003069 dimer interface [polypeptide binding]; other site 749219003070 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 749219003071 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 749219003072 Ligand Binding Site [chemical binding]; other site 749219003073 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 749219003074 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 749219003075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749219003076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003077 S-adenosylmethionine binding site [chemical binding]; other site 749219003078 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 749219003079 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219003080 phosphoenolpyruvate synthase; Validated; Region: PRK06464 749219003081 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 749219003082 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 749219003083 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 749219003084 PEP synthetase regulatory protein; Provisional; Region: PRK05339 749219003085 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 749219003086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749219003087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219003088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219003089 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 749219003090 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 749219003091 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 749219003092 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 749219003093 Substrate binding site; other site 749219003094 metal-binding site 749219003095 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 749219003096 Phosphotransferase enzyme family; Region: APH; pfam01636 749219003097 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 749219003098 OstA-like protein; Region: OstA; cl00844 749219003099 Organic solvent tolerance protein; Region: OstA_C; pfam04453 749219003100 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 749219003101 SurA N-terminal domain; Region: SurA_N; pfam09312 749219003102 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 749219003103 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 749219003104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219003105 Peptidase family M23; Region: Peptidase_M23; pfam01551 749219003106 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 749219003107 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 749219003108 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 749219003109 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 749219003110 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219003111 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 749219003112 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 749219003113 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219003114 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749219003115 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 749219003116 IMP binding site; other site 749219003117 dimer interface [polypeptide binding]; other site 749219003118 interdomain contacts; other site 749219003119 partial ornithine binding site; other site 749219003120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 749219003121 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 749219003122 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 749219003123 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 749219003124 catalytic site [active] 749219003125 subunit interface [polypeptide binding]; other site 749219003126 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 749219003127 SelR domain; Region: SelR; pfam01641 749219003128 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 749219003129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749219003130 sequence-specific DNA binding site [nucleotide binding]; other site 749219003131 salt bridge; other site 749219003132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219003133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003134 homodimer interface [polypeptide binding]; other site 749219003135 catalytic residue [active] 749219003136 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 749219003137 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749219003138 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749219003139 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 749219003140 siroheme synthase; Provisional; Region: cysG; PRK10637 749219003141 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 749219003142 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 749219003143 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 749219003144 active site 749219003145 SAM binding site [chemical binding]; other site 749219003146 homodimer interface [polypeptide binding]; other site 749219003147 maleylacetoacetate isomerase; Region: maiA; TIGR01262 749219003148 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003149 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 749219003150 dimer interface [polypeptide binding]; other site 749219003151 N-terminal domain interface [polypeptide binding]; other site 749219003152 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 749219003153 hypothetical protein; Provisional; Region: PRK14013 749219003154 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 749219003155 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 749219003156 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 749219003157 homodimer interface [polypeptide binding]; other site 749219003158 substrate-cofactor binding pocket; other site 749219003159 catalytic residue [active] 749219003160 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 749219003161 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219003162 metal binding triad; other site 749219003163 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 749219003164 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219003165 metal binding triad; other site 749219003166 DsrE/DsrF-like family; Region: DrsE; cl00672 749219003167 DsrC like protein; Region: DsrC; pfam04358 749219003168 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 749219003169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749219003170 G1 box; other site 749219003171 GTP/Mg2+ binding site [chemical binding]; other site 749219003172 G2 box; other site 749219003173 Switch I region; other site 749219003174 G3 box; other site 749219003175 Switch II region; other site 749219003176 G4 box; other site 749219003177 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 749219003178 ABC1 family; Region: ABC1; cl17513 749219003179 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 749219003180 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 749219003181 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 749219003182 ATP binding site [chemical binding]; other site 749219003183 substrate interface [chemical binding]; other site 749219003184 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 749219003185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003186 muropeptide transporter; Validated; Region: ampG; cl17669 749219003187 muropeptide transporter; Validated; Region: ampG; cl17669 749219003188 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 749219003189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219003190 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 749219003191 substrate binding site [chemical binding]; other site 749219003192 dimerization interface [polypeptide binding]; other site 749219003193 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 749219003194 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 749219003195 transmembrane helices; other site 749219003196 Glycerate kinase family; Region: Gly_kinase; cl00841 749219003197 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 749219003198 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 749219003199 active site 749219003200 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 749219003201 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 749219003202 dimer interface [polypeptide binding]; other site 749219003203 substrate binding site [chemical binding]; other site 749219003204 metal binding sites [ion binding]; metal-binding site 749219003205 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 749219003206 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 749219003207 Tetramer interface [polypeptide binding]; other site 749219003208 active site 749219003209 FMN-binding site [chemical binding]; other site 749219003210 hypothetical protein; Provisional; Region: PRK01752 749219003211 SEC-C motif; Region: SEC-C; pfam02810 749219003212 polyphosphate kinase; Provisional; Region: PRK05443 749219003213 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 749219003214 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 749219003215 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749219003216 putative active site [active] 749219003217 catalytic site [active] 749219003218 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 749219003219 putative domain interface [polypeptide binding]; other site 749219003220 putative active site [active] 749219003221 catalytic site [active] 749219003222 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 749219003223 Transglycosylase; Region: Transgly; cl17702 749219003224 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 749219003225 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 749219003226 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749219003227 substrate binding pocket [chemical binding]; other site 749219003228 chain length determination region; other site 749219003229 substrate-Mg2+ binding site; other site 749219003230 catalytic residues [active] 749219003231 aspartate-rich region 1; other site 749219003232 active site lid residues [active] 749219003233 aspartate-rich region 2; other site 749219003234 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 749219003235 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 749219003236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 749219003237 Smr domain; Region: Smr; pfam01713 749219003238 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 749219003239 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 749219003240 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 749219003241 RNA/DNA hybrid binding site [nucleotide binding]; other site 749219003242 active site 749219003243 GTP-binding protein Der; Reviewed; Region: PRK00093 749219003244 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 749219003245 G1 box; other site 749219003246 GTP/Mg2+ binding site [chemical binding]; other site 749219003247 Switch I region; other site 749219003248 G2 box; other site 749219003249 Switch II region; other site 749219003250 G3 box; other site 749219003251 G4 box; other site 749219003252 G5 box; other site 749219003253 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 749219003254 G1 box; other site 749219003255 GTP/Mg2+ binding site [chemical binding]; other site 749219003256 Switch I region; other site 749219003257 G2 box; other site 749219003258 G3 box; other site 749219003259 Switch II region; other site 749219003260 G4 box; other site 749219003261 G5 box; other site 749219003262 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 749219003263 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 749219003264 Trp docking motif [polypeptide binding]; other site 749219003265 active site 749219003266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 749219003267 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 749219003268 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 749219003269 dimer interface [polypeptide binding]; other site 749219003270 motif 1; other site 749219003271 active site 749219003272 motif 2; other site 749219003273 motif 3; other site 749219003274 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 749219003275 anticodon binding site; other site 749219003276 Protein of unknown function (DUF511); Region: DUF511; cl01114 749219003277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 749219003278 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 749219003279 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 749219003280 TPR repeat; Region: TPR_11; pfam13414 749219003281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219003282 binding surface 749219003283 TPR motif; other site 749219003284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219003285 TPR motif; other site 749219003286 binding surface 749219003287 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 749219003288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219003289 FeS/SAM binding site; other site 749219003290 HemK family putative methylases; Region: hemK_fam; TIGR00536 749219003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003292 S-adenosylmethionine binding site [chemical binding]; other site 749219003293 Uncharacterized conserved protein [Function unknown]; Region: COG2850 749219003294 Cupin-like domain; Region: Cupin_8; pfam13621 749219003295 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 749219003296 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 749219003297 putative active site [active] 749219003298 putative PHP Thumb interface [polypeptide binding]; other site 749219003299 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 749219003300 generic binding surface I; other site 749219003301 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 749219003302 serine O-acetyltransferase; Region: cysE; TIGR01172 749219003303 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 749219003304 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 749219003305 trimer interface [polypeptide binding]; other site 749219003306 active site 749219003307 substrate binding site [chemical binding]; other site 749219003308 CoA binding site [chemical binding]; other site 749219003309 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 749219003310 mechanosensitive channel MscS; Provisional; Region: PRK10334 749219003311 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219003312 short chain dehydrogenase; Provisional; Region: PRK08251 749219003313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003314 NAD(P) binding site [chemical binding]; other site 749219003315 active site 749219003316 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 749219003317 putative inner membrane peptidase; Provisional; Region: PRK11778 749219003318 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 749219003319 tandem repeat interface [polypeptide binding]; other site 749219003320 oligomer interface [polypeptide binding]; other site 749219003321 active site residues [active] 749219003322 potassium/proton antiporter; Reviewed; Region: PRK05326 749219003323 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 749219003324 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 749219003325 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 749219003326 dimer interface [polypeptide binding]; other site 749219003327 anticodon binding site; other site 749219003328 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 749219003329 homodimer interface [polypeptide binding]; other site 749219003330 motif 1; other site 749219003331 active site 749219003332 motif 2; other site 749219003333 GAD domain; Region: GAD; pfam02938 749219003334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749219003335 active site 749219003336 motif 3; other site 749219003337 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 749219003338 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 749219003339 putative acyl-acceptor binding pocket; other site 749219003340 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 749219003341 FMN binding site [chemical binding]; other site 749219003342 dimer interface [polypeptide binding]; other site 749219003343 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 749219003344 Domain of unknown function (DUF329); Region: DUF329; pfam03884 749219003345 Uncharacterized conserved protein [Function unknown]; Region: COG2966 749219003346 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 749219003347 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 749219003348 Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819 749219003349 putative trimer interface [polypeptide binding]; other site 749219003350 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 749219003351 trimer interface [polypeptide binding]; other site 749219003352 YadA-like C-terminal region; Region: YadA; pfam03895 749219003353 2-isopropylmalate synthase; Validated; Region: PRK03739 749219003354 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 749219003355 active site 749219003356 catalytic residues [active] 749219003357 metal binding site [ion binding]; metal-binding site 749219003358 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 749219003359 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749219003360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749219003361 putative DNA binding site [nucleotide binding]; other site 749219003362 putative Zn2+ binding site [ion binding]; other site 749219003363 AsnC family; Region: AsnC_trans_reg; pfam01037 749219003364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749219003365 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 749219003366 homodimer interface [polypeptide binding]; other site 749219003367 substrate-cofactor binding pocket; other site 749219003368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003369 catalytic residue [active] 749219003370 Peptidase M15; Region: Peptidase_M15_3; cl01194 749219003371 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 749219003372 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 749219003373 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749219003374 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749219003375 Walker A/P-loop; other site 749219003376 ATP binding site [chemical binding]; other site 749219003377 Q-loop/lid; other site 749219003378 ABC transporter signature motif; other site 749219003379 Walker B; other site 749219003380 D-loop; other site 749219003381 H-loop/switch region; other site 749219003382 NMT1/THI5 like; Region: NMT1; pfam09084 749219003383 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749219003384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003385 dimer interface [polypeptide binding]; other site 749219003386 conserved gate region; other site 749219003387 putative PBP binding loops; other site 749219003388 ABC-ATPase subunit interface; other site 749219003389 H+ Antiporter protein; Region: 2A0121; TIGR00900 749219003390 serine endoprotease; Provisional; Region: PRK10898 749219003391 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749219003392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749219003393 protein binding site [polypeptide binding]; other site 749219003394 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 749219003395 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 749219003396 substrate binding site [chemical binding]; other site 749219003397 active site 749219003398 GTPase CgtA; Reviewed; Region: obgE; PRK12298 749219003399 GTP1/OBG; Region: GTP1_OBG; pfam01018 749219003400 Obg GTPase; Region: Obg; cd01898 749219003401 G1 box; other site 749219003402 GTP/Mg2+ binding site [chemical binding]; other site 749219003403 Switch I region; other site 749219003404 G2 box; other site 749219003405 G3 box; other site 749219003406 Switch II region; other site 749219003407 G4 box; other site 749219003408 G5 box; other site 749219003409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219003410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749219003411 Coenzyme A binding pocket [chemical binding]; other site 749219003412 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 749219003413 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 749219003414 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 749219003415 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 749219003416 active site 749219003417 8-oxo-dGMP binding site [chemical binding]; other site 749219003418 nudix motif; other site 749219003419 metal binding site [ion binding]; metal-binding site 749219003420 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 749219003421 thiamine phosphate binding site [chemical binding]; other site 749219003422 Hemin uptake protein hemP; Region: hemP; cl10043 749219003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 749219003424 Family of unknown function (DUF490); Region: DUF490; pfam04357 749219003425 Surface antigen; Region: Bac_surface_Ag; pfam01103 749219003426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219003427 putative substrate translocation pore; other site 749219003428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 749219003429 binding surface 749219003430 TPR motif; other site 749219003431 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749219003432 adenylate kinase; Reviewed; Region: adk; PRK00279 749219003433 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 749219003434 AMP-binding site [chemical binding]; other site 749219003435 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 749219003436 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 749219003437 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 749219003438 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 749219003439 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 749219003441 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 749219003442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 749219003443 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 749219003444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003445 S-adenosylmethionine binding site [chemical binding]; other site 749219003446 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 749219003447 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 749219003448 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 749219003449 active site 749219003450 homodimer interface [polypeptide binding]; other site 749219003451 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 749219003452 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 749219003453 dimerization interface 3.5A [polypeptide binding]; other site 749219003454 active site 749219003455 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 749219003456 rRNA binding site [nucleotide binding]; other site 749219003457 predicted 30S ribosome binding site; other site 749219003458 Putative serine esterase (DUF676); Region: DUF676; pfam05057 749219003459 PGAP1-like protein; Region: PGAP1; pfam07819 749219003460 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 749219003461 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 749219003462 eyelet of channel; other site 749219003463 trimer interface [polypeptide binding]; other site 749219003464 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 749219003465 active site 749219003466 dinuclear metal binding site [ion binding]; other site 749219003467 dimerization interface [polypeptide binding]; other site 749219003468 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 749219003469 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 749219003470 putative substrate binding site [chemical binding]; other site 749219003471 putative ATP binding site [chemical binding]; other site 749219003472 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 749219003473 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 749219003474 Permutation of conserved domain; other site 749219003475 active site 749219003476 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 749219003477 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749219003478 trimer interface [polypeptide binding]; other site 749219003479 active site 749219003480 LrgB-like family; Region: LrgB; pfam04172 749219003481 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 749219003482 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 749219003483 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 749219003484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219003485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749219003486 putative substrate translocation pore; other site 749219003487 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 749219003488 Part of AAA domain; Region: AAA_19; pfam13245 749219003489 Family description; Region: UvrD_C_2; pfam13538 749219003490 GTPase RsgA; Reviewed; Region: PRK12288 749219003491 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 749219003492 RNA binding site [nucleotide binding]; other site 749219003493 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 749219003494 GTPase/Zn-binding domain interface [polypeptide binding]; other site 749219003495 GTP/Mg2+ binding site [chemical binding]; other site 749219003496 G4 box; other site 749219003497 G5 box; other site 749219003498 G1 box; other site 749219003499 Switch I region; other site 749219003500 G2 box; other site 749219003501 G3 box; other site 749219003502 Switch II region; other site 749219003503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219003504 active site residue [active] 749219003505 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 749219003506 GSH binding site [chemical binding]; other site 749219003507 catalytic residues [active] 749219003508 preprotein translocase subunit SecB; Validated; Region: PRK05751 749219003509 SecA binding site; other site 749219003510 Preprotein binding site; other site 749219003511 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749219003512 trimer interface [polypeptide binding]; other site 749219003513 active site 749219003514 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 749219003515 N-acetyl-L-glutamate binding site [chemical binding]; other site 749219003516 nucleotide binding site [chemical binding]; other site 749219003517 Rhomboid family; Region: Rhomboid; cl11446 749219003518 Ion transport protein; Region: Ion_trans; pfam00520 749219003519 Ion channel; Region: Ion_trans_2; pfam07885 749219003520 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 749219003521 Predicted flavoprotein [General function prediction only]; Region: COG0431 749219003522 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749219003523 META domain; Region: META; pfam03724 749219003524 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 749219003525 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 749219003526 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 749219003527 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 749219003528 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 749219003529 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 749219003530 YcgL domain; Region: YcgL; cl01189 749219003531 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 749219003532 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749219003533 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 749219003534 lipoyl attachment site [posttranslational modification]; other site 749219003535 glycine dehydrogenase; Provisional; Region: PRK05367 749219003536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219003537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219003538 catalytic residue [active] 749219003539 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 749219003540 tetramer interface [polypeptide binding]; other site 749219003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003542 catalytic residue [active] 749219003543 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 749219003544 Carbon starvation protein CstA; Region: CstA; pfam02554 749219003545 Carbon starvation protein CstA; Region: CstA; pfam02554 749219003546 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 749219003547 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 749219003548 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 749219003549 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 749219003550 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 749219003551 Na binding site [ion binding]; other site 749219003552 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 749219003553 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 749219003554 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 749219003555 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 749219003556 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 749219003557 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 749219003558 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 749219003559 Sulfatase; Region: Sulfatase; pfam00884 749219003560 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 749219003561 active site 749219003562 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003563 ArsC family; Region: ArsC; pfam03960 749219003564 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 749219003565 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 749219003566 HIGH motif; other site 749219003567 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219003568 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219003569 active site 749219003570 KMSKS motif; other site 749219003571 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 749219003572 tRNA binding surface [nucleotide binding]; other site 749219003573 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 749219003574 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 749219003575 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 749219003576 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 749219003577 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 749219003578 eyelet of channel; other site 749219003579 trimer interface [polypeptide binding]; other site 749219003580 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 749219003581 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 749219003582 peptide binding site [polypeptide binding]; other site 749219003583 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 749219003584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749219003585 Walker A/P-loop; other site 749219003586 ATP binding site [chemical binding]; other site 749219003587 Q-loop/lid; other site 749219003588 ABC transporter signature motif; other site 749219003589 Walker B; other site 749219003590 D-loop; other site 749219003591 H-loop/switch region; other site 749219003592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 749219003593 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749219003594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749219003595 Walker A/P-loop; other site 749219003596 ATP binding site [chemical binding]; other site 749219003597 Q-loop/lid; other site 749219003598 ABC transporter signature motif; other site 749219003599 Walker B; other site 749219003600 D-loop; other site 749219003601 H-loop/switch region; other site 749219003602 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749219003603 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749219003604 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 749219003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003606 dimer interface [polypeptide binding]; other site 749219003607 conserved gate region; other site 749219003608 putative PBP binding loops; other site 749219003609 ABC-ATPase subunit interface; other site 749219003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749219003612 dimer interface [polypeptide binding]; other site 749219003613 conserved gate region; other site 749219003614 putative PBP binding loops; other site 749219003615 ABC-ATPase subunit interface; other site 749219003616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 749219003617 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 749219003618 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 749219003619 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 749219003620 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 749219003621 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 749219003622 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 749219003623 tandem repeat interface [polypeptide binding]; other site 749219003624 oligomer interface [polypeptide binding]; other site 749219003625 active site residues [active] 749219003626 Competence protein; Region: Competence; pfam03772 749219003627 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 749219003628 substrate binding site; other site 749219003629 dimer interface; other site 749219003630 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 749219003631 Septum formation initiator; Region: DivIC; cl17659 749219003632 enolase; Provisional; Region: eno; PRK00077 749219003633 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 749219003634 dimer interface [polypeptide binding]; other site 749219003635 metal binding site [ion binding]; metal-binding site 749219003636 substrate binding pocket [chemical binding]; other site 749219003637 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 749219003638 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 749219003639 CTP synthetase; Validated; Region: pyrG; PRK05380 749219003640 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 749219003641 Catalytic site [active] 749219003642 active site 749219003643 UTP binding site [chemical binding]; other site 749219003644 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 749219003645 active site 749219003646 putative oxyanion hole; other site 749219003647 catalytic triad [active] 749219003648 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 749219003649 Cytochrome c; Region: Cytochrom_C; pfam00034 749219003650 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 749219003651 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 749219003652 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 749219003653 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 749219003654 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 749219003655 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 749219003656 Low-spin heme binding site [chemical binding]; other site 749219003657 Putative water exit pathway; other site 749219003658 Binuclear center (active site) [active] 749219003659 Putative proton exit pathway; other site 749219003660 SCP-2 sterol transfer family; Region: SCP2; cl01225 749219003661 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 749219003662 4Fe-4S binding domain; Region: Fer4_5; pfam12801 749219003663 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 749219003664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 749219003665 FixH; Region: FixH; pfam05751 749219003666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219003667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219003668 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 749219003669 substrate binding pocket [chemical binding]; other site 749219003670 dimerization interface [polypeptide binding]; other site 749219003671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749219003672 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749219003673 argininosuccinate synthase; Validated; Region: PRK05370 749219003674 argininosuccinate synthase; Provisional; Region: PRK13820 749219003675 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 749219003676 active site 749219003677 substrate binding pocket [chemical binding]; other site 749219003678 dimer interface [polypeptide binding]; other site 749219003679 ribonuclease T; Provisional; Region: PRK05168 749219003680 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 749219003681 active site 749219003682 catalytic site [active] 749219003683 substrate binding site [chemical binding]; other site 749219003684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 749219003685 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 749219003686 Pirin; Region: Pirin; pfam02678 749219003687 Pirin-related protein [General function prediction only]; Region: COG1741 749219003688 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 749219003689 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 749219003690 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 749219003691 UbiA prenyltransferase family; Region: UbiA; pfam01040 749219003692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003693 S-adenosylmethionine binding site [chemical binding]; other site 749219003694 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 749219003695 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 749219003696 Glycoprotease family; Region: Peptidase_M22; pfam00814 749219003697 signal recognition particle protein; Provisional; Region: PRK10867 749219003698 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 749219003699 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 749219003700 P loop; other site 749219003701 GTP binding site [chemical binding]; other site 749219003702 Signal peptide binding domain; Region: SRP_SPB; pfam02978 749219003703 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 749219003704 Protein of unknown function (DUF493); Region: DUF493; pfam04359 749219003705 exonuclease subunit SbcD; Provisional; Region: PRK10966 749219003706 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 749219003707 active site 749219003708 metal binding site [ion binding]; metal-binding site 749219003709 DNA binding site [nucleotide binding] 749219003710 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 749219003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219003712 AAA domain; Region: AAA_23; pfam13476 749219003713 Walker A/P-loop; other site 749219003714 ATP binding site [chemical binding]; other site 749219003715 Q-loop/lid; other site 749219003716 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 749219003717 Q-loop/lid; other site 749219003718 ABC transporter signature motif; other site 749219003719 Walker B; other site 749219003720 D-loop; other site 749219003721 H-loop/switch region; other site 749219003722 Hemerythrin-like domain; Region: Hr-like; cd12108 749219003723 Predicted permeases [General function prediction only]; Region: COG0679 749219003724 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 749219003725 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 749219003726 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 749219003727 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 749219003728 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 749219003729 23S rRNA interface [nucleotide binding]; other site 749219003730 L3 interface [polypeptide binding]; other site 749219003731 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 749219003732 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 749219003733 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 749219003734 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 749219003735 [2Fe-2S] cluster binding site [ion binding]; other site 749219003736 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 749219003737 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 749219003738 Qi binding site; other site 749219003739 intrachain domain interface; other site 749219003740 interchain domain interface [polypeptide binding]; other site 749219003741 heme bH binding site [chemical binding]; other site 749219003742 heme bL binding site [chemical binding]; other site 749219003743 Qo binding site; other site 749219003744 interchain domain interface [polypeptide binding]; other site 749219003745 intrachain domain interface; other site 749219003746 Qi binding site; other site 749219003747 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 749219003748 Qo binding site; other site 749219003749 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 749219003750 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 749219003751 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003752 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 749219003753 N-terminal domain interface [polypeptide binding]; other site 749219003754 dimer interface [polypeptide binding]; other site 749219003755 substrate binding pocket (H-site) [chemical binding]; other site 749219003756 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 749219003757 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 749219003758 Clp amino terminal domain; Region: Clp_N; pfam02861 749219003759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219003760 Walker A motif; other site 749219003761 ATP binding site [chemical binding]; other site 749219003762 Walker B motif; other site 749219003763 arginine finger; other site 749219003764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219003765 Walker A motif; other site 749219003766 ATP binding site [chemical binding]; other site 749219003767 Walker B motif; other site 749219003768 arginine finger; other site 749219003769 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 749219003770 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 749219003771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219003772 Walker A/P-loop; other site 749219003773 ATP binding site [chemical binding]; other site 749219003774 Q-loop/lid; other site 749219003775 ABC transporter signature motif; other site 749219003776 Walker B; other site 749219003777 D-loop; other site 749219003778 H-loop/switch region; other site 749219003779 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 749219003780 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 749219003781 TM-ABC transporter signature motif; other site 749219003782 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 749219003783 zinc binding site [ion binding]; other site 749219003784 putative ligand binding site [chemical binding]; other site 749219003785 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 749219003786 zinc binding site [ion binding]; other site 749219003787 putative ligand binding site [chemical binding]; other site 749219003788 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749219003789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003790 S-adenosylmethionine binding site [chemical binding]; other site 749219003791 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 749219003792 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 749219003793 active site 749219003794 catalytic triad [active] 749219003795 oxyanion hole [active] 749219003796 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749219003797 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 749219003798 active site 749219003799 oxyanion hole [active] 749219003800 catalytic triad [active] 749219003801 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 749219003802 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 749219003803 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 749219003804 aminopeptidase N; Provisional; Region: pepN; PRK14015 749219003805 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 749219003806 Zn binding site [ion binding]; other site 749219003807 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 749219003808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219003809 ligand binding site [chemical binding]; other site 749219003810 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 749219003811 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 749219003812 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 749219003813 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 749219003814 substrate binding site [chemical binding]; other site 749219003815 dimerization interface [polypeptide binding]; other site 749219003816 active site 749219003817 calcium binding site [ion binding]; other site 749219003818 ribonuclease PH; Reviewed; Region: rph; PRK00173 749219003819 Ribonuclease PH; Region: RNase_PH_bact; cd11362 749219003820 hexamer interface [polypeptide binding]; other site 749219003821 active site 749219003822 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 749219003823 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 749219003824 acyl-activating enzyme (AAE) consensus motif; other site 749219003825 putative AMP binding site [chemical binding]; other site 749219003826 putative active site [active] 749219003827 putative CoA binding site [chemical binding]; other site 749219003828 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 749219003829 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 749219003830 acyl-activating enzyme (AAE) consensus motif; other site 749219003831 putative AMP binding site [chemical binding]; other site 749219003832 putative active site [active] 749219003833 putative CoA binding site [chemical binding]; other site 749219003834 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 749219003835 Flavoprotein; Region: Flavoprotein; pfam02441 749219003836 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 749219003837 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 749219003838 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 749219003839 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 749219003840 Cytochrome c553 [Energy production and conversion]; Region: COG2863 749219003841 Cytochrome c; Region: Cytochrom_C; cl11414 749219003842 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 749219003843 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 749219003844 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 749219003845 active site 749219003846 HIGH motif; other site 749219003847 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 749219003848 KMSKS motif; other site 749219003849 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 749219003850 tRNA binding surface [nucleotide binding]; other site 749219003851 anticodon binding site; other site 749219003852 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 749219003853 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 749219003854 active site 749219003855 HIGH motif; other site 749219003856 KMSKS motif; other site 749219003857 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 749219003858 tRNA binding surface [nucleotide binding]; other site 749219003859 anticodon binding site; other site 749219003860 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 749219003861 dimer interface [polypeptide binding]; other site 749219003862 putative tRNA-binding site [nucleotide binding]; other site 749219003863 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749219003864 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749219003865 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 749219003866 ThiS interaction site; other site 749219003867 putative active site [active] 749219003868 tetramer interface [polypeptide binding]; other site 749219003869 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219003870 active site residue [active] 749219003871 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 749219003872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 749219003873 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 749219003874 active site 749219003875 dimerization interface [polypeptide binding]; other site 749219003876 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 749219003877 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 749219003878 TPP-binding site; other site 749219003879 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749219003880 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749219003881 PYR/PP interface [polypeptide binding]; other site 749219003882 dimer interface [polypeptide binding]; other site 749219003883 TPP binding site [chemical binding]; other site 749219003884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749219003885 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749219003886 dimerization interface [polypeptide binding]; other site 749219003887 active site 749219003888 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 749219003889 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 749219003890 Cytochrome C' Region: Cytochrom_C_2; pfam01322 749219003891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 749219003892 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219003893 Sporulation related domain; Region: SPOR; pfam05036 749219003894 NnrS protein; Region: NnrS; pfam05940 749219003895 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 749219003896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219003897 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 749219003898 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 749219003899 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 749219003900 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 749219003901 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 749219003902 substrate binding site [chemical binding]; other site 749219003903 active site 749219003904 catalytic residues [active] 749219003905 heterodimer interface [polypeptide binding]; other site 749219003906 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 749219003907 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 749219003908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003909 catalytic residue [active] 749219003910 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 749219003911 active site 749219003912 prolyl-tRNA synthetase; Provisional; Region: PRK09194 749219003913 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 749219003914 dimer interface [polypeptide binding]; other site 749219003915 motif 1; other site 749219003916 active site 749219003917 motif 2; other site 749219003918 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 749219003919 putative deacylase active site [active] 749219003920 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749219003921 active site 749219003922 motif 3; other site 749219003923 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 749219003924 anticodon binding site; other site 749219003925 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 749219003926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 749219003927 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 749219003928 inner membrane transport permease; Provisional; Region: PRK15066 749219003929 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749219003930 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749219003931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749219003932 Walker A/P-loop; other site 749219003933 ATP binding site [chemical binding]; other site 749219003934 Q-loop/lid; other site 749219003935 ABC transporter signature motif; other site 749219003936 Walker B; other site 749219003937 D-loop; other site 749219003938 H-loop/switch region; other site 749219003939 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 749219003940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 749219003941 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 749219003942 dimer interface [polypeptide binding]; other site 749219003943 active site 749219003944 metal binding site [ion binding]; metal-binding site 749219003945 glutathione binding site [chemical binding]; other site 749219003946 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 749219003947 active site clefts [active] 749219003948 zinc binding site [ion binding]; other site 749219003949 dimer interface [polypeptide binding]; other site 749219003950 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 749219003951 active site 749219003952 dimer interface [polypeptide binding]; other site 749219003953 metal binding site [ion binding]; metal-binding site 749219003954 shikimate kinase; Reviewed; Region: aroK; PRK00131 749219003955 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 749219003956 ADP binding site [chemical binding]; other site 749219003957 magnesium binding site [ion binding]; other site 749219003958 putative shikimate binding site; other site 749219003959 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 749219003960 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 749219003961 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 749219003962 Pilus assembly protein, PilP; Region: PilP; pfam04351 749219003963 Pilus assembly protein, PilO; Region: PilO; cl01234 749219003964 Competence protein A; Region: Competence_A; pfam11104 749219003965 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 749219003966 catalytic residue [active] 749219003967 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 749219003968 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 749219003969 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749219003970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219003971 FeS/SAM binding site; other site 749219003972 TRAM domain; Region: TRAM; cl01282 749219003973 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 749219003974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749219003975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219003976 catalytic residue [active] 749219003977 malate dehydrogenase; Provisional; Region: PRK05442 749219003978 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 749219003979 NAD(P) binding site [chemical binding]; other site 749219003980 dimer interface [polypeptide binding]; other site 749219003981 malate binding site [chemical binding]; other site 749219003982 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 749219003983 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 749219003984 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 749219003985 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 749219003986 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 749219003987 active site 749219003988 dimer interface [polypeptide binding]; other site 749219003989 motif 1; other site 749219003990 motif 2; other site 749219003991 motif 3; other site 749219003992 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 749219003993 anticodon binding site; other site 749219003994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219003995 Walker A/P-loop; other site 749219003996 ATP binding site [chemical binding]; other site 749219003997 ABC transporter signature motif; other site 749219003998 Walker B; other site 749219003999 D-loop; other site 749219004000 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 749219004001 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 749219004002 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 749219004003 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 749219004004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219004005 Coenzyme A binding pocket [chemical binding]; other site 749219004006 ribonuclease R; Region: RNase_R; TIGR02063 749219004007 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 749219004008 RNB domain; Region: RNB; pfam00773 749219004009 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 749219004010 RNA binding site [nucleotide binding]; other site 749219004011 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 749219004012 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 749219004013 catalytic residues [active] 749219004014 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 749219004015 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219004016 E3 interaction surface; other site 749219004017 lipoyl attachment site [posttranslational modification]; other site 749219004018 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 749219004019 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 749219004020 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 749219004021 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 749219004022 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 749219004023 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 749219004024 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 749219004025 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 749219004026 FAD binding pocket [chemical binding]; other site 749219004027 FAD binding motif [chemical binding]; other site 749219004028 phosphate binding motif [ion binding]; other site 749219004029 beta-alpha-beta structure motif; other site 749219004030 NAD binding pocket [chemical binding]; other site 749219004031 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 749219004032 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 749219004033 tetramer interface [polypeptide binding]; other site 749219004034 heme binding pocket [chemical binding]; other site 749219004035 NADPH binding site [chemical binding]; other site 749219004036 AbgT putative transporter family; Region: ABG_transport; pfam03806 749219004037 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 749219004038 Flavin Reductases; Region: FlaRed; cl00801 749219004039 methionine synthase; Provisional; Region: PRK01207 749219004040 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 749219004041 substrate binding site [chemical binding]; other site 749219004042 THF binding site; other site 749219004043 zinc-binding site [ion binding]; other site 749219004044 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 749219004045 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 749219004046 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749219004047 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 749219004048 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 749219004049 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 749219004050 protein binding site [polypeptide binding]; other site 749219004051 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 749219004052 pseudouridine synthase; Region: TIGR00093 749219004053 active site 749219004054 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 749219004055 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219004056 ligand binding site [chemical binding]; other site 749219004057 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 749219004058 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 749219004059 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749219004060 substrate binding site [chemical binding]; other site 749219004061 oxyanion hole (OAH) forming residues; other site 749219004062 trimer interface [polypeptide binding]; other site 749219004063 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 749219004064 hypothetical protein; Validated; Region: PRK02101 749219004065 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 749219004066 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 749219004067 propionate/acetate kinase; Provisional; Region: PRK12379 749219004068 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 749219004069 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 749219004070 diaminopimelate decarboxylase; Region: lysA; TIGR01048 749219004071 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 749219004072 active site 749219004073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219004074 substrate binding site [chemical binding]; other site 749219004075 catalytic residues [active] 749219004076 dimer interface [polypeptide binding]; other site 749219004077 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 749219004078 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 749219004079 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 749219004080 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749219004081 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 749219004082 active site 749219004083 DNA binding site [nucleotide binding] 749219004084 Int/Topo IB signature motif; other site 749219004085 hypothetical protein; Provisional; Region: PRK09126 749219004086 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 749219004087 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 749219004088 ApbE family; Region: ApbE; pfam02424 749219004089 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 749219004090 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 749219004091 folate binding site [chemical binding]; other site 749219004092 NADP+ binding site [chemical binding]; other site 749219004093 thymidylate synthase; Reviewed; Region: thyA; PRK01827 749219004094 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 749219004095 dimerization interface [polypeptide binding]; other site 749219004096 active site 749219004097 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 749219004098 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 749219004099 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749219004100 ring oligomerisation interface [polypeptide binding]; other site 749219004101 ATP/Mg binding site [chemical binding]; other site 749219004102 stacking interactions; other site 749219004103 hinge regions; other site 749219004104 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 749219004105 oligomerisation interface [polypeptide binding]; other site 749219004106 mobile loop; other site 749219004107 roof hairpin; other site 749219004108 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 749219004109 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749219004110 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 749219004111 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 749219004112 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 749219004113 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 749219004114 CHC2 zinc finger; Region: zf-CHC2; cl17510 749219004115 Helix-turn-helix domain; Region: HTH_39; pfam14090 749219004116 AAA domain; Region: AAA_14; pfam13173 749219004117 integrase; Provisional; Region: PRK09692 749219004118 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 749219004119 active site 749219004120 Int/Topo IB signature motif; other site 749219004121 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 749219004122 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219004123 metal binding triad; other site 749219004124 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 749219004125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749219004126 Zn2+ binding site [ion binding]; other site 749219004127 Mg2+ binding site [ion binding]; other site 749219004128 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749219004129 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 749219004130 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 749219004131 active site 749219004132 Putative phosphatase (DUF442); Region: DUF442; cl17385 749219004133 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 749219004134 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 749219004135 active site 749219004136 FMN binding site [chemical binding]; other site 749219004137 2,4-decadienoyl-CoA binding site; other site 749219004138 catalytic residue [active] 749219004139 4Fe-4S cluster binding site [ion binding]; other site 749219004140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 749219004141 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 749219004142 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 749219004143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219004144 Walker A motif; other site 749219004145 ATP binding site [chemical binding]; other site 749219004146 Walker B motif; other site 749219004147 arginine finger; other site 749219004148 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 749219004149 ATP-dependent helicase HepA; Validated; Region: PRK04914 749219004150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219004151 ATP binding site [chemical binding]; other site 749219004152 putative Mg++ binding site [ion binding]; other site 749219004153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219004154 nucleotide binding region [chemical binding]; other site 749219004155 ATP-binding site [chemical binding]; other site 749219004156 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 749219004157 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 749219004158 putative ligand binding site [chemical binding]; other site 749219004159 putative NAD binding site [chemical binding]; other site 749219004160 catalytic site [active] 749219004161 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 749219004162 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749219004163 substrate binding pocket [chemical binding]; other site 749219004164 chain length determination region; other site 749219004165 substrate-Mg2+ binding site; other site 749219004166 catalytic residues [active] 749219004167 aspartate-rich region 1; other site 749219004168 active site lid residues [active] 749219004169 aspartate-rich region 2; other site 749219004170 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 749219004171 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749219004172 minor groove reading motif; other site 749219004173 helix-hairpin-helix signature motif; other site 749219004174 substrate binding pocket [chemical binding]; other site 749219004175 active site 749219004176 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 749219004177 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749219004178 nudix motif; other site 749219004179 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 749219004180 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 749219004181 active site 749219004182 substrate binding site [chemical binding]; other site 749219004183 Mg2+ binding site [ion binding]; other site 749219004184 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 749219004185 Nitrogen regulatory protein P-II; Region: P-II; smart00938 749219004186 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 749219004187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219004188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219004189 cell division protein FtsW; Region: ftsW; TIGR02614 749219004190 multidrug efflux protein; Reviewed; Region: PRK01766 749219004191 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 749219004192 cation binding site [ion binding]; other site 749219004193 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 749219004194 active site 749219004195 putative DNA-binding cleft [nucleotide binding]; other site 749219004196 dimer interface [polypeptide binding]; other site 749219004197 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749219004198 DNA-binding site [nucleotide binding]; DNA binding site 749219004199 RNA-binding motif; other site 749219004200 ketol-acid reductoisomerase; Provisional; Region: PRK05479 749219004201 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 749219004202 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 749219004203 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 749219004204 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 749219004205 putative valine binding site [chemical binding]; other site 749219004206 dimer interface [polypeptide binding]; other site 749219004207 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 749219004208 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 749219004209 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749219004210 PYR/PP interface [polypeptide binding]; other site 749219004211 dimer interface [polypeptide binding]; other site 749219004212 TPP binding site [chemical binding]; other site 749219004213 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749219004214 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 749219004215 TPP-binding site [chemical binding]; other site 749219004216 dimer interface [polypeptide binding]; other site 749219004217 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 749219004218 BON domain; Region: BON; pfam04972 749219004219 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749219004220 acyl carrier protein; Provisional; Region: acpP; PRK00982 749219004221 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 749219004222 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749219004223 NAD(P) binding site [chemical binding]; other site 749219004224 homotetramer interface [polypeptide binding]; other site 749219004225 homodimer interface [polypeptide binding]; other site 749219004226 active site 749219004227 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 749219004228 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 749219004229 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 749219004230 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 749219004231 Protein of unknown function, DUF462; Region: DUF462; pfam04315 749219004232 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 749219004233 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 749219004234 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 749219004235 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 749219004236 alphaNTD homodimer interface [polypeptide binding]; other site 749219004237 alphaNTD - beta interaction site [polypeptide binding]; other site 749219004238 alphaNTD - beta' interaction site [polypeptide binding]; other site 749219004239 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 749219004240 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 749219004241 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 749219004242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219004243 RNA binding surface [nucleotide binding]; other site 749219004244 30S ribosomal protein S11; Validated; Region: PRK05309 749219004245 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 749219004246 30S ribosomal protein S13; Region: bact_S13; TIGR03631 749219004247 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 749219004248 SecY translocase; Region: SecY; pfam00344 749219004249 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 749219004250 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 749219004251 23S rRNA binding site [nucleotide binding]; other site 749219004252 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 749219004253 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 749219004254 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 749219004255 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 749219004256 5S rRNA interface [nucleotide binding]; other site 749219004257 23S rRNA interface [nucleotide binding]; other site 749219004258 L5 interface [polypeptide binding]; other site 749219004259 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 749219004260 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749219004261 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749219004262 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 749219004263 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 749219004264 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 749219004265 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 749219004266 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 749219004267 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 749219004268 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 749219004269 RNA binding site [nucleotide binding]; other site 749219004270 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 749219004271 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 749219004272 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 749219004273 23S rRNA interface [nucleotide binding]; other site 749219004274 putative translocon interaction site; other site 749219004275 signal recognition particle (SRP54) interaction site; other site 749219004276 L23 interface [polypeptide binding]; other site 749219004277 trigger factor interaction site; other site 749219004278 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 749219004279 23S rRNA interface [nucleotide binding]; other site 749219004280 5S rRNA interface [nucleotide binding]; other site 749219004281 putative antibiotic binding site [chemical binding]; other site 749219004282 L25 interface [polypeptide binding]; other site 749219004283 L27 interface [polypeptide binding]; other site 749219004284 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 749219004285 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 749219004286 G-X-X-G motif; other site 749219004287 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 749219004288 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 749219004289 putative translocon binding site; other site 749219004290 protein-rRNA interface [nucleotide binding]; other site 749219004291 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 749219004292 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 749219004293 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 749219004294 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 749219004295 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 749219004296 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 749219004297 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 749219004298 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 749219004299 ribonuclease G; Provisional; Region: PRK11712 749219004300 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 749219004301 homodimer interface [polypeptide binding]; other site 749219004302 oligonucleotide binding site [chemical binding]; other site 749219004303 Maf-like protein; Region: Maf; pfam02545 749219004304 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 749219004305 active site 749219004306 dimer interface [polypeptide binding]; other site 749219004307 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 749219004308 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 749219004309 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 749219004310 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 749219004311 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 749219004312 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 749219004313 GatB domain; Region: GatB_Yqey; smart00845 749219004314 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 749219004315 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 749219004316 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219004317 ligand binding site [chemical binding]; other site 749219004318 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 749219004319 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 749219004320 putative acyl-acceptor binding pocket; other site 749219004321 septum formation inhibitor; Reviewed; Region: minC; PRK04804 749219004322 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 749219004323 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 749219004324 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 749219004325 Switch I; other site 749219004326 Switch II; other site 749219004327 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 749219004328 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 749219004329 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 749219004330 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 749219004331 Na binding site [ion binding]; other site 749219004332 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 749219004333 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 749219004334 5S rRNA interface [nucleotide binding]; other site 749219004335 CTC domain interface [polypeptide binding]; other site 749219004336 L16 interface [polypeptide binding]; other site 749219004337 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 749219004338 putative active site [active] 749219004339 catalytic residue [active] 749219004340 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 749219004341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219004342 FeS/SAM binding site; other site 749219004343 HemN C-terminal domain; Region: HemN_C; pfam06969 749219004344 RDD family; Region: RDD; pfam06271 749219004345 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 749219004346 dimer interface [polypeptide binding]; other site 749219004347 substrate binding site [chemical binding]; other site 749219004348 ATP binding site [chemical binding]; other site 749219004349 YGGT family; Region: YGGT; pfam02325 749219004350 YGGT family; Region: YGGT; pfam02325 749219004351 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 749219004352 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 749219004353 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 749219004354 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 749219004355 Ligand Binding Site [chemical binding]; other site 749219004356 TilS substrate binding domain; Region: TilS; pfam09179 749219004357 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 749219004358 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 749219004359 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 749219004360 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 749219004361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219004362 RNA binding surface [nucleotide binding]; other site 749219004363 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 749219004364 active site 749219004365 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 749219004366 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 749219004367 homodimer interface [polypeptide binding]; other site 749219004368 oligonucleotide binding site [chemical binding]; other site 749219004369 malate synthase G; Provisional; Region: PRK02999 749219004370 active site 749219004371 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749219004372 tetramer interface [polypeptide binding]; other site 749219004373 active site 749219004374 Mg2+/Mn2+ binding site [ion binding]; other site 749219004375 isocitrate lyase; Region: PLN02892 749219004376 Chorismate lyase; Region: Chor_lyase; cl01230 749219004377 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 749219004378 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 749219004379 dimer interface [polypeptide binding]; other site 749219004380 active site 749219004381 glycine-pyridoxal phosphate binding site [chemical binding]; other site 749219004382 folate binding site [chemical binding]; other site 749219004383 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 749219004384 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 749219004385 Helix-turn-helix domain; Region: HTH_39; pfam14090 749219004386 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 749219004387 Uncharacterized conserved protein [Function unknown]; Region: COG2433 749219004388 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749219004389 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749219004390 synthetase active site [active] 749219004391 NTP binding site [chemical binding]; other site 749219004392 metal binding site [ion binding]; metal-binding site 749219004393 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 749219004394 oligomeric interface; other site 749219004395 putative active site [active] 749219004396 homodimer interface [polypeptide binding]; other site 749219004397 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 749219004398 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 749219004399 active site 749219004400 Int/Topo IB signature motif; other site 749219004401 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 749219004402 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 749219004403 DALR anticodon binding domain; Region: DALR_1; pfam05746 749219004404 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 749219004405 dimer interface [polypeptide binding]; other site 749219004406 motif 1; other site 749219004407 active site 749219004408 motif 2; other site 749219004409 motif 3; other site 749219004410 PspC domain; Region: PspC; pfam04024 749219004411 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 749219004412 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 749219004413 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 749219004414 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 749219004415 HI0933-like protein; Region: HI0933_like; pfam03486 749219004416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749219004417 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 749219004418 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 749219004419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219004420 Peptidase M16C associated; Region: M16C_assoc; pfam08367 749219004421 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219004422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749219004423 Ligand Binding Site [chemical binding]; other site 749219004424 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 749219004425 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 749219004426 substrate binding site [chemical binding]; other site 749219004427 ATP binding site [chemical binding]; other site 749219004428 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 749219004429 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 749219004430 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 749219004431 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 749219004432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219004433 active site 749219004434 nucleotide binding site [chemical binding]; other site 749219004435 HIGH motif; other site 749219004436 KMSKS motif; other site 749219004437 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749219004438 nudix motif; other site 749219004439 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 749219004440 TrkA-N domain; Region: TrkA_N; pfam02254 749219004441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219004442 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219004443 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 749219004444 acetoin reductases; Region: 23BDH; TIGR02415 749219004445 NAD binding site [chemical binding]; other site 749219004446 homotetramer interface [polypeptide binding]; other site 749219004447 homodimer interface [polypeptide binding]; other site 749219004448 active site 749219004449 substrate binding site [chemical binding]; other site 749219004450 Domain of unknown function DUF302; Region: DUF302; cl01364 749219004451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219004452 active site residue [active] 749219004453 LysE type translocator; Region: LysE; cl00565 749219004454 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 749219004455 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 749219004456 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749219004457 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 749219004458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219004459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219004460 ABC transporter; Region: ABC_tran_2; pfam12848 749219004461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749219004462 Predicted acetyltransferase [General function prediction only]; Region: COG2388 749219004463 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 749219004464 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 749219004465 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 749219004466 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 749219004467 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749219004468 active site 749219004469 flagellar motor protein MotS; Reviewed; Region: PRK06925 749219004470 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 749219004471 ligand binding site [chemical binding]; other site 749219004472 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749219004473 dimer interface [polypeptide binding]; other site 749219004474 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 749219004475 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 749219004476 aromatic arch; other site 749219004477 DCoH dimer interaction site [polypeptide binding]; other site 749219004478 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 749219004479 DCoH tetramer interaction site [polypeptide binding]; other site 749219004480 substrate binding site [chemical binding]; other site 749219004481 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 749219004482 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 749219004483 CAP-like domain; other site 749219004484 active site 749219004485 primary dimer interface [polypeptide binding]; other site 749219004486 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 749219004487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004488 S-adenosylmethionine binding site [chemical binding]; other site 749219004489 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749219004490 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 749219004491 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 749219004492 G1 box; other site 749219004493 putative GEF interaction site [polypeptide binding]; other site 749219004494 GTP/Mg2+ binding site [chemical binding]; other site 749219004495 Switch I region; other site 749219004496 G2 box; other site 749219004497 G3 box; other site 749219004498 Switch II region; other site 749219004499 G4 box; other site 749219004500 G5 box; other site 749219004501 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 749219004502 DNA polymerase I; Provisional; Region: PRK05755 749219004503 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 749219004504 active site 749219004505 metal binding site 1 [ion binding]; metal-binding site 749219004506 putative 5' ssDNA interaction site; other site 749219004507 metal binding site 3; metal-binding site 749219004508 metal binding site 2 [ion binding]; metal-binding site 749219004509 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 749219004510 putative DNA binding site [nucleotide binding]; other site 749219004511 putative metal binding site [ion binding]; other site 749219004512 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 749219004513 active site 749219004514 catalytic site [active] 749219004515 substrate binding site [chemical binding]; other site 749219004516 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 749219004517 active site 749219004518 DNA binding site [nucleotide binding] 749219004519 catalytic site [active] 749219004520 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 749219004521 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 749219004522 active site 749219004523 interdomain interaction site; other site 749219004524 putative metal-binding site [ion binding]; other site 749219004525 nucleotide binding site [chemical binding]; other site 749219004526 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 749219004527 domain I; other site 749219004528 DNA binding groove [nucleotide binding] 749219004529 phosphate binding site [ion binding]; other site 749219004530 domain II; other site 749219004531 domain III; other site 749219004532 nucleotide binding site [chemical binding]; other site 749219004533 catalytic site [active] 749219004534 domain IV; other site 749219004535 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 749219004536 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 749219004537 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 749219004538 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 749219004539 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 749219004540 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 749219004541 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 749219004542 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749219004543 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 749219004544 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 749219004545 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 749219004546 Walker A/P-loop; other site 749219004547 ATP binding site [chemical binding]; other site 749219004548 Q-loop/lid; other site 749219004549 ABC transporter signature motif; other site 749219004550 Walker B; other site 749219004551 D-loop; other site 749219004552 H-loop/switch region; other site 749219004553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004554 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004555 substrate binding pocket [chemical binding]; other site 749219004556 membrane-bound complex binding site; other site 749219004557 hinge residues; other site 749219004558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004560 substrate binding pocket [chemical binding]; other site 749219004561 membrane-bound complex binding site; other site 749219004562 hinge residues; other site 749219004563 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004565 substrate binding pocket [chemical binding]; other site 749219004566 membrane-bound complex binding site; other site 749219004567 hinge residues; other site 749219004568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 749219004569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004570 dimer interface [polypeptide binding]; other site 749219004571 conserved gate region; other site 749219004572 putative PBP binding loops; other site 749219004573 ABC-ATPase subunit interface; other site 749219004574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 749219004575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004576 dimer interface [polypeptide binding]; other site 749219004577 conserved gate region; other site 749219004578 putative PBP binding loops; other site 749219004579 ABC-ATPase subunit interface; other site 749219004580 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 749219004581 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 749219004582 Substrate binding site; other site 749219004583 Mg++ binding site; other site 749219004584 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 749219004585 active site 749219004586 substrate binding site [chemical binding]; other site 749219004587 CoA binding site [chemical binding]; other site 749219004588 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 749219004589 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 749219004590 G1 box; other site 749219004591 putative GEF interaction site [polypeptide binding]; other site 749219004592 GTP/Mg2+ binding site [chemical binding]; other site 749219004593 Switch I region; other site 749219004594 G2 box; other site 749219004595 G3 box; other site 749219004596 Switch II region; other site 749219004597 G4 box; other site 749219004598 G5 box; other site 749219004599 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 749219004600 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 749219004601 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 749219004602 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 749219004603 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219004604 ligand binding site [chemical binding]; other site 749219004605 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 749219004606 active site 749219004607 hydrophilic channel; other site 749219004608 dimerization interface [polypeptide binding]; other site 749219004609 catalytic residues [active] 749219004610 active site lid [active] 749219004611 Recombination protein O N terminal; Region: RecO_N; pfam11967 749219004612 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 749219004613 Recombination protein O C terminal; Region: RecO_C; pfam02565 749219004614 GTPase Era; Reviewed; Region: era; PRK00089 749219004615 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 749219004616 G1 box; other site 749219004617 GTP/Mg2+ binding site [chemical binding]; other site 749219004618 Switch I region; other site 749219004619 G2 box; other site 749219004620 Switch II region; other site 749219004621 G3 box; other site 749219004622 G4 box; other site 749219004623 G5 box; other site 749219004624 KH domain; Region: KH_2; pfam07650 749219004625 ribonuclease III; Reviewed; Region: rnc; PRK00102 749219004626 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 749219004627 dimerization interface [polypeptide binding]; other site 749219004628 active site 749219004629 metal binding site [ion binding]; metal-binding site 749219004630 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 749219004631 dsRNA binding site [nucleotide binding]; other site 749219004632 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 749219004633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749219004634 Catalytic site [active] 749219004635 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749219004636 GTP-binding protein LepA; Provisional; Region: PRK05433 749219004637 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 749219004638 G1 box; other site 749219004639 putative GEF interaction site [polypeptide binding]; other site 749219004640 GTP/Mg2+ binding site [chemical binding]; other site 749219004641 Switch I region; other site 749219004642 G2 box; other site 749219004643 G3 box; other site 749219004644 Switch II region; other site 749219004645 G4 box; other site 749219004646 G5 box; other site 749219004647 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 749219004648 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 749219004649 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 749219004650 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 749219004651 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 749219004652 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 749219004653 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 749219004654 active site 749219004655 (T/H)XGH motif; other site 749219004656 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 749219004657 dimer interface [polypeptide binding]; other site 749219004658 FMN binding site [chemical binding]; other site 749219004659 NADPH bind site [chemical binding]; other site 749219004660 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 749219004661 SmpB-tmRNA interface; other site 749219004662 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 749219004663 EamA-like transporter family; Region: EamA; pfam00892 749219004664 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 749219004665 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 749219004666 nucleotide binding pocket [chemical binding]; other site 749219004667 K-X-D-G motif; other site 749219004668 catalytic site [active] 749219004669 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 749219004670 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 749219004671 Helix-hairpin-helix motif; Region: HHH; pfam00633 749219004672 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 749219004673 Dimer interface [polypeptide binding]; other site 749219004674 BRCT sequence motif; other site 749219004675 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 749219004676 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 749219004677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219004678 active site 749219004679 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 749219004680 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749219004681 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 749219004682 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 749219004683 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749219004684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219004685 Walker A/P-loop; other site 749219004686 ATP binding site [chemical binding]; other site 749219004687 Q-loop/lid; other site 749219004688 ABC transporter signature motif; other site 749219004689 Walker B; other site 749219004690 D-loop; other site 749219004691 H-loop/switch region; other site 749219004692 TOBE domain; Region: TOBE_2; pfam08402 749219004693 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749219004694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004695 dimer interface [polypeptide binding]; other site 749219004696 conserved gate region; other site 749219004697 putative PBP binding loops; other site 749219004698 ABC-ATPase subunit interface; other site 749219004699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749219004700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749219004701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004702 dimer interface [polypeptide binding]; other site 749219004703 putative PBP binding loops; other site 749219004704 ABC-ATPase subunit interface; other site 749219004705 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 749219004706 Sulfatase; Region: Sulfatase; cl17466 749219004707 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 749219004708 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 749219004709 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 749219004710 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 749219004711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219004712 dimer interface [polypeptide binding]; other site 749219004713 phosphorylation site [posttranslational modification] 749219004714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219004715 ATP binding site [chemical binding]; other site 749219004716 Mg2+ binding site [ion binding]; other site 749219004717 G-X-G motif; other site 749219004718 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 749219004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219004720 active site 749219004721 phosphorylation site [posttranslational modification] 749219004722 intermolecular recognition site; other site 749219004723 dimerization interface [polypeptide binding]; other site 749219004724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219004725 DNA binding site [nucleotide binding] 749219004726 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 749219004727 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 749219004728 Walker A/P-loop; other site 749219004729 ATP binding site [chemical binding]; other site 749219004730 Q-loop/lid; other site 749219004731 ABC transporter signature motif; other site 749219004732 Walker B; other site 749219004733 D-loop; other site 749219004734 H-loop/switch region; other site 749219004735 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 749219004736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004737 dimer interface [polypeptide binding]; other site 749219004738 conserved gate region; other site 749219004739 putative PBP binding loops; other site 749219004740 ABC-ATPase subunit interface; other site 749219004741 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 749219004742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004743 dimer interface [polypeptide binding]; other site 749219004744 conserved gate region; other site 749219004745 putative PBP binding loops; other site 749219004746 ABC-ATPase subunit interface; other site 749219004747 PBP superfamily domain; Region: PBP_like_2; cl17296 749219004748 Peptidase family M48; Region: Peptidase_M48; pfam01435 749219004749 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 749219004750 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 749219004751 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 749219004752 Sulfate transporter family; Region: Sulfate_transp; pfam00916 749219004753 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 749219004754 Putative phosphatase (DUF442); Region: DUF442; cl17385 749219004755 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 749219004756 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 749219004757 active site 749219004758 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749219004759 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 749219004760 catalytic residues [active] 749219004761 transcription termination factor Rho; Provisional; Region: rho; PRK09376 749219004762 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 749219004763 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 749219004764 RNA binding site [nucleotide binding]; other site 749219004765 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 749219004766 multimer interface [polypeptide binding]; other site 749219004767 Walker A motif; other site 749219004768 ATP binding site [chemical binding]; other site 749219004769 Walker B motif; other site 749219004770 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 749219004771 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 749219004772 Fumarase C-terminus; Region: Fumerase_C; pfam05683 749219004773 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 749219004774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219004775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004776 homodimer interface [polypeptide binding]; other site 749219004777 catalytic residue [active] 749219004778 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 749219004779 histidinol dehydrogenase; Region: hisD; TIGR00069 749219004780 NAD binding site [chemical binding]; other site 749219004781 dimerization interface [polypeptide binding]; other site 749219004782 product binding site; other site 749219004783 substrate binding site [chemical binding]; other site 749219004784 zinc binding site [ion binding]; other site 749219004785 catalytic residues [active] 749219004786 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 749219004787 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 749219004788 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 749219004789 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 749219004790 hinge; other site 749219004791 active site 749219004792 BolA-like protein; Region: BolA; pfam01722 749219004793 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 749219004794 BON domain; Region: BON; pfam04972 749219004795 hypothetical protein; Reviewed; Region: PRK12497 749219004796 RDD family; Region: RDD; pfam06271 749219004797 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 749219004798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 749219004799 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 749219004800 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 749219004801 RNase E interface [polypeptide binding]; other site 749219004802 trimer interface [polypeptide binding]; other site 749219004803 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 749219004804 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 749219004805 RNase E interface [polypeptide binding]; other site 749219004806 trimer interface [polypeptide binding]; other site 749219004807 active site 749219004808 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 749219004809 putative nucleic acid binding region [nucleotide binding]; other site 749219004810 G-X-X-G motif; other site 749219004811 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 749219004812 RNA binding site [nucleotide binding]; other site 749219004813 domain interface; other site 749219004814 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 749219004815 16S/18S rRNA binding site [nucleotide binding]; other site 749219004816 S13e-L30e interaction site [polypeptide binding]; other site 749219004817 25S rRNA binding site [nucleotide binding]; other site 749219004818 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 749219004819 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 749219004820 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 749219004821 RNA binding site [nucleotide binding]; other site 749219004822 active site 749219004823 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 749219004824 ribosome-binding factor A; Provisional; Region: PRK13816 749219004825 PRC-barrel domain; Region: PRC; pfam05239 749219004826 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 749219004827 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 749219004828 translation initiation factor IF-2; Region: IF-2; TIGR00487 749219004829 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 749219004830 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 749219004831 G1 box; other site 749219004832 putative GEF interaction site [polypeptide binding]; other site 749219004833 GTP/Mg2+ binding site [chemical binding]; other site 749219004834 Switch I region; other site 749219004835 G2 box; other site 749219004836 G3 box; other site 749219004837 Switch II region; other site 749219004838 G4 box; other site 749219004839 G5 box; other site 749219004840 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 749219004841 Translation-initiation factor 2; Region: IF-2; pfam11987 749219004842 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 749219004843 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 749219004844 NusA N-terminal domain; Region: NusA_N; pfam08529 749219004845 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 749219004846 RNA binding site [nucleotide binding]; other site 749219004847 homodimer interface [polypeptide binding]; other site 749219004848 NusA-like KH domain; Region: KH_5; pfam13184 749219004849 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 749219004850 G-X-X-G motif; other site 749219004851 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 749219004852 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 749219004853 ribosome maturation protein RimP; Reviewed; Region: PRK00092 749219004854 Sm and related proteins; Region: Sm_like; cl00259 749219004855 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 749219004856 putative oligomer interface [polypeptide binding]; other site 749219004857 putative RNA binding site [nucleotide binding]; other site 749219004858 protein translocase, SecG subunit; Region: secG; TIGR00810 749219004859 triosephosphate isomerase; Provisional; Region: PRK14567 749219004860 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 749219004861 substrate binding site [chemical binding]; other site 749219004862 dimer interface [polypeptide binding]; other site 749219004863 catalytic triad [active] 749219004864 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 749219004865 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 749219004866 Mg++ binding site [ion binding]; other site 749219004867 putative catalytic motif [active] 749219004868 putative substrate binding site [chemical binding]; other site 749219004869 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219004870 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 749219004871 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219004872 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219004873 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 749219004874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219004875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219004876 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 749219004877 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 749219004878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 749219004879 Cell division protein FtsL; Region: FtsL; pfam04999 749219004880 MraW methylase family; Region: Methyltransf_5; cl17771 749219004881 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 749219004882 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 749219004883 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 749219004884 HIGH motif; other site 749219004885 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 749219004886 active site 749219004887 KMSKS motif; other site 749219004888 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 749219004889 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 749219004890 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 749219004891 putative active site [active] 749219004892 putative dimer interface [polypeptide binding]; other site 749219004893 homoserine kinase; Provisional; Region: PRK05231 749219004894 active site 749219004895 substrate binding site [chemical binding]; other site 749219004896 ATP binding site [chemical binding]; other site 749219004897 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 749219004898 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 749219004899 substrate binding site [chemical binding]; other site 749219004900 glutamase interaction surface [polypeptide binding]; other site 749219004901 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 749219004902 homopentamer interface [polypeptide binding]; other site 749219004903 active site 749219004904 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 749219004905 putative RNA binding site [nucleotide binding]; other site 749219004906 thiamine monophosphate kinase; Provisional; Region: PRK05731 749219004907 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 749219004908 ATP binding site [chemical binding]; other site 749219004909 dimerization interface [polypeptide binding]; other site 749219004910 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 749219004911 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 749219004912 tetramer interfaces [polypeptide binding]; other site 749219004913 binuclear metal-binding site [ion binding]; other site 749219004914 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 749219004915 HNH endonuclease; Region: HNH_2; pfam13391 749219004916 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 749219004917 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 749219004918 cofactor binding site; other site 749219004919 DNA binding site [nucleotide binding] 749219004920 substrate interaction site [chemical binding]; other site 749219004921 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 749219004922 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 749219004923 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 749219004924 dimerization interface [polypeptide binding]; other site 749219004925 domain crossover interface; other site 749219004926 redox-dependent activation switch; other site 749219004927 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 749219004928 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 749219004929 glutaminase active site [active] 749219004930 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749219004931 dimer interface [polypeptide binding]; other site 749219004932 active site 749219004933 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 749219004934 dimer interface [polypeptide binding]; other site 749219004935 active site 749219004936 UDP-glucose 4-epimerase; Region: PLN02240 749219004937 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 749219004938 NAD binding site [chemical binding]; other site 749219004939 homodimer interface [polypeptide binding]; other site 749219004940 active site 749219004941 substrate binding site [chemical binding]; other site 749219004942 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 749219004943 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 749219004944 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 749219004945 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 749219004946 active site 749219004947 dimer interface [polypeptide binding]; other site 749219004948 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 749219004949 dimer interface [polypeptide binding]; other site 749219004950 active site 749219004951 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 749219004952 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 749219004953 active site 749219004954 tetramer interface; other site 749219004955 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 749219004956 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 749219004957 putative acyl-acceptor binding pocket; other site 749219004958 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 749219004959 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 749219004960 active site 749219004961 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 749219004962 catalytic triad [active] 749219004963 dimer interface [polypeptide binding]; other site 749219004964 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 749219004965 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 749219004966 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 749219004967 Predicted permeases [General function prediction only]; Region: COG0795 749219004968 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 749219004969 multifunctional aminopeptidase A; Provisional; Region: PRK00913 749219004970 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 749219004971 interface (dimer of trimers) [polypeptide binding]; other site 749219004972 Substrate-binding/catalytic site; other site 749219004973 Zn-binding sites [ion binding]; other site 749219004974 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 749219004975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219004976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004977 homodimer interface [polypeptide binding]; other site 749219004978 catalytic residue [active] 749219004979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219004980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749219004981 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 749219004982 putative dimerization interface [polypeptide binding]; other site 749219004983 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 749219004984 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 749219004985 Domain of unknown function DUF21; Region: DUF21; pfam01595 749219004986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219004987 Transporter associated domain; Region: CorC_HlyC; smart01091 749219004988 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 749219004989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004990 NAD(P) binding site [chemical binding]; other site 749219004991 active site 749219004992 phosphoglycolate phosphatase; Provisional; Region: PRK13222 749219004993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 749219004994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219004995 motif II; other site 749219004996 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 749219004997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004998 S-adenosylmethionine binding site [chemical binding]; other site 749219004999 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 749219005000 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 749219005001 catalytic residues [active] 749219005002 hinge region; other site 749219005003 alpha helical domain; other site 749219005004 Protein of unknown function (DUF615); Region: DUF615; pfam04751 749219005005 Microtubule Interacting and Trafficking molecule domain; Region: MIT; smart00745 749219005006 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 749219005007 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 749219005008 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 749219005009 pantoate--beta-alanine ligase; Region: panC; TIGR00018 749219005010 Pantoate-beta-alanine ligase; Region: PanC; cd00560 749219005011 active site 749219005012 ATP-binding site [chemical binding]; other site 749219005013 pantoate-binding site; other site 749219005014 HXXH motif; other site 749219005015 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 749219005016 oligomerization interface [polypeptide binding]; other site 749219005017 active site 749219005018 metal binding site [ion binding]; metal-binding site 749219005019 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 749219005020 catalytic center binding site [active] 749219005021 ATP binding site [chemical binding]; other site 749219005022 poly(A) polymerase; Region: pcnB; TIGR01942 749219005023 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 749219005024 active site 749219005025 NTP binding site [chemical binding]; other site 749219005026 metal binding triad [ion binding]; metal-binding site 749219005027 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 749219005028 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 749219005029 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 749219005030 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 749219005031 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 749219005032 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 749219005033 homodimer interface [polypeptide binding]; other site 749219005034 metal binding site [ion binding]; metal-binding site 749219005035 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 749219005036 homodimer interface [polypeptide binding]; other site 749219005037 active site 749219005038 putative chemical substrate binding site [chemical binding]; other site 749219005039 metal binding site [ion binding]; metal-binding site 749219005040 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 749219005041 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749219005042 dimer interface [polypeptide binding]; other site 749219005043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219005044 catalytic residue [active] 749219005045 phosphomannomutase CpsG; Provisional; Region: PRK15414 749219005046 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 749219005047 active site 749219005048 substrate binding site [chemical binding]; other site 749219005049 metal binding site [ion binding]; metal-binding site 749219005050 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 749219005051 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 749219005052 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 749219005053 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 749219005054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219005055 putative substrate translocation pore; other site 749219005056 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749219005057 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749219005058 dimer interface [polypeptide binding]; other site 749219005059 active site 749219005060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749219005061 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 749219005062 active site 749219005063 DNA binding site [nucleotide binding] 749219005064 Int/Topo IB signature motif; other site 749219005065 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 749219005066 CPxP motif; other site 749219005067 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 749219005068 hypothetical protein; Validated; Region: PRK00228 749219005069 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 749219005070 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 749219005071 Walker A/P-loop; other site 749219005072 ATP binding site [chemical binding]; other site 749219005073 Q-loop/lid; other site 749219005074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749219005075 ABC transporter signature motif; other site 749219005076 Walker B; other site 749219005077 D-loop; other site 749219005078 H-loop/switch region; other site 749219005079 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 749219005080 active site 749219005081 catalytic residues [active] 749219005082 metal binding site [ion binding]; metal-binding site 749219005083 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 749219005084 putative active site pocket [active] 749219005085 4-fold oligomerization interface [polypeptide binding]; other site 749219005086 metal binding residues [ion binding]; metal-binding site 749219005087 3-fold/trimer interface [polypeptide binding]; other site 749219005088 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 749219005089 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 749219005090 putative active site [active] 749219005091 oxyanion strand; other site 749219005092 catalytic triad [active] 749219005093 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 749219005094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219005095 ATP binding site [chemical binding]; other site 749219005096 Mg2+ binding site [ion binding]; other site 749219005097 G-X-G motif; other site 749219005098 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 749219005099 anchoring element; other site 749219005100 dimer interface [polypeptide binding]; other site 749219005101 ATP binding site [chemical binding]; other site 749219005102 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 749219005103 active site 749219005104 metal binding site [ion binding]; metal-binding site 749219005105 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749219005106 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 749219005107 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 749219005108 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 749219005109 metal binding site [ion binding]; metal-binding site 749219005110 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 749219005111 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 749219005112 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 749219005113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219005114 ABC-ATPase subunit interface; other site 749219005115 dimer interface [polypeptide binding]; other site 749219005116 putative PBP binding regions; other site 749219005117 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 749219005118 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219005119 ABC-ATPase subunit interface; other site 749219005120 dimer interface [polypeptide binding]; other site 749219005121 putative PBP binding regions; other site 749219005122 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 749219005123 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 749219005124 active site 749219005125 HIGH motif; other site 749219005126 dimer interface [polypeptide binding]; other site 749219005127 KMSKS motif; other site 749219005128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219005129 RNA binding surface [nucleotide binding]; other site 749219005130 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 749219005131 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 749219005132 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 749219005133 cofactor binding site; other site 749219005134 DNA binding site [nucleotide binding] 749219005135 substrate interaction site [chemical binding]; other site 749219005136 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749219005137 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 749219005138 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 749219005139 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 749219005140 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 749219005141 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219005142 inhibitor-cofactor binding pocket; inhibition site 749219005143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219005144 catalytic residue [active] 749219005145 Arginase family; Region: Arginase; cd09989 749219005146 active site 749219005147 Mn binding site [ion binding]; other site 749219005148 oligomer interface [polypeptide binding]; other site 749219005149 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 749219005150 Domain of unknown function (DUF389); Region: DUF389; cl00781 749219005151 Domain of unknown function (DUF389); Region: DUF389; pfam04087 749219005152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219005153 S-adenosylmethionine binding site [chemical binding]; other site 749219005154 recombination factor protein RarA; Reviewed; Region: PRK13342 749219005155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219005156 Walker A motif; other site 749219005157 ATP binding site [chemical binding]; other site 749219005158 Walker B motif; other site 749219005159 arginine finger; other site 749219005160 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 749219005161 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 749219005162 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 749219005163 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 749219005164 dimerization interface [polypeptide binding]; other site 749219005165 active site 749219005166 Predicted membrane protein [Function unknown]; Region: COG2261 749219005167 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 749219005168 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 749219005169 DNA protecting protein DprA; Region: dprA; TIGR00732 749219005170 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 749219005171 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 749219005172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219005173 catalytic residue [active] 749219005174 16S rRNA methyltransferase B; Provisional; Region: PRK10901 749219005175 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 749219005176 putative RNA binding site [nucleotide binding]; other site 749219005177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219005178 S-adenosylmethionine binding site [chemical binding]; other site 749219005179 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 749219005180 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 749219005181 putative active site [active] 749219005182 substrate binding site [chemical binding]; other site 749219005183 putative cosubstrate binding site; other site 749219005184 catalytic site [active] 749219005185 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 749219005186 substrate binding site [chemical binding]; other site 749219005187 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 749219005188 Lumazine binding domain; Region: Lum_binding; pfam00677 749219005189 Lumazine binding domain; Region: Lum_binding; pfam00677 749219005190 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 749219005191 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 749219005192 catalytic motif [active] 749219005193 Zn binding site [ion binding]; other site 749219005194 RibD C-terminal domain; Region: RibD_C; cl17279 749219005195 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 749219005196 ATP cone domain; Region: ATP-cone; pfam03477 749219005197 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 749219005198 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 749219005199 trmE is a tRNA modification GTPase; Region: trmE; cd04164 749219005200 G1 box; other site 749219005201 GTP/Mg2+ binding site [chemical binding]; other site 749219005202 Switch I region; other site 749219005203 G2 box; other site 749219005204 Switch II region; other site 749219005205 G3 box; other site 749219005206 G4 box; other site 749219005207 G5 box; other site 749219005208 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 749219005209 membrane protein insertase; Provisional; Region: PRK01318 749219005210 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 749219005211 hypothetical protein; Provisional; Region: PRK14370