-- dump date 20120504_152720 -- class Genbank::misc_feature -- table misc_feature_note -- id note 749219000001 Ribonuclease P; Region: Ribonuclease_P; cl00457 749219000002 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 749219000003 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 749219000004 DnaA N-terminal domain; Region: DnaA_N; pfam11638 749219000005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000006 Walker A motif; other site 749219000007 ATP binding site [chemical binding]; other site 749219000008 Walker B motif; other site 749219000009 arginine finger; other site 749219000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 749219000011 DnaA box-binding interface [nucleotide binding]; other site 749219000012 DNA polymerase III subunit beta; Validated; Region: PRK05643 749219000013 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 749219000014 putative DNA binding surface [nucleotide binding]; other site 749219000015 dimer interface [polypeptide binding]; other site 749219000016 beta-clamp/clamp loader binding surface; other site 749219000017 beta-clamp/translesion DNA polymerase binding surface; other site 749219000018 recombination protein F; Reviewed; Region: recF; PRK00064 749219000019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000020 Walker A/P-loop; other site 749219000021 ATP binding site [chemical binding]; other site 749219000022 Q-loop/lid; other site 749219000023 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 749219000024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000025 Mg2+ binding site [ion binding]; other site 749219000026 G-X-G motif; other site 749219000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 749219000028 anchoring element; other site 749219000029 dimer interface [polypeptide binding]; other site 749219000030 ATP binding site [chemical binding]; other site 749219000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 749219000032 active site 749219000033 putative metal-binding site [ion binding]; other site 749219000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749219000035 GMP synthase; Reviewed; Region: guaA; PRK00074 749219000036 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 749219000037 AMP/PPi binding site [chemical binding]; other site 749219000038 candidate oxyanion hole; other site 749219000039 catalytic triad [active] 749219000040 potential glutamine specificity residues [chemical binding]; other site 749219000041 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 749219000042 ATP Binding subdomain [chemical binding]; other site 749219000043 Ligand Binding sites [chemical binding]; other site 749219000044 Dimerization subdomain; other site 749219000045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 749219000046 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 749219000047 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 749219000048 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749219000049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 749219000050 dimer interface [polypeptide binding]; other site 749219000051 active site 749219000052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219000053 catalytic residues [active] 749219000054 substrate binding site [chemical binding]; other site 749219000055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000057 homodimer interface [polypeptide binding]; other site 749219000058 catalytic residue [active] 749219000059 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 749219000060 homotrimer interaction site [polypeptide binding]; other site 749219000061 putative active site [active] 749219000062 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 749219000063 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 749219000064 ThiC-associated domain; Region: ThiC-associated; pfam13667 749219000065 ThiC family; Region: ThiC; cl08031 749219000066 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749219000067 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 749219000068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000069 Walker A/P-loop; other site 749219000070 ATP binding site [chemical binding]; other site 749219000071 Q-loop/lid; other site 749219000072 ABC transporter signature motif; other site 749219000073 Walker B; other site 749219000074 D-loop; other site 749219000075 H-loop/switch region; other site 749219000076 argininosuccinate lyase; Provisional; Region: PRK00855 749219000077 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 749219000078 active sites [active] 749219000079 tetramer interface [polypeptide binding]; other site 749219000080 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 749219000081 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 749219000082 domain interfaces; other site 749219000083 active site 749219000084 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 749219000085 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 749219000086 active site 749219000087 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 749219000088 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 749219000089 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 749219000090 Protein of unknown function (DUF539); Region: DUF539; cl01129 749219000091 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 749219000092 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 749219000093 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 749219000094 dimer interface [polypeptide binding]; other site 749219000095 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 749219000096 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 749219000097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000098 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 749219000099 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 749219000100 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cl12127 749219000101 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 749219000102 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 749219000103 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 749219000104 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749219000105 active site 749219000106 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 749219000107 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219000108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219000109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219000110 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 749219000111 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 749219000112 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 749219000113 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 749219000114 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 749219000115 Walker A/P-loop; other site 749219000116 ATP binding site [chemical binding]; other site 749219000117 Q-loop/lid; other site 749219000118 ABC transporter signature motif; other site 749219000119 Walker B; other site 749219000120 D-loop; other site 749219000121 H-loop/switch region; other site 749219000122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000123 dimer interface [polypeptide binding]; other site 749219000124 conserved gate region; other site 749219000125 putative PBP binding loops; other site 749219000126 ABC-ATPase subunit interface; other site 749219000127 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749219000128 NMT1-like family; Region: NMT1_2; cl15260 749219000129 Rubredoxin [Energy production and conversion]; Region: COG1773 749219000130 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 749219000131 iron binding site [ion binding]; other site 749219000132 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 749219000133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000134 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749219000135 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749219000136 active site 749219000137 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749219000138 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749219000139 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 749219000140 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219000141 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219000142 ABC transporter; Region: ABC_tran_2; pfam12848 749219000143 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219000144 chaperone protein DnaJ; Provisional; Region: PRK14299 749219000145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000146 HSP70 interaction site [polypeptide binding]; other site 749219000147 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 749219000148 dimer interface [polypeptide binding]; other site 749219000149 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 749219000150 dihydrodipicolinate reductase; Provisional; Region: PRK00048 749219000151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000152 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 749219000153 cystathionine beta-lyase; Provisional; Region: PRK07050 749219000154 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219000155 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000156 catalytic residue [active] 749219000157 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 749219000158 Membrane transport protein; Region: Mem_trans; cl09117 749219000159 chaperone protein DnaJ; Provisional; Region: PRK10767 749219000160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000161 HSP70 interaction site [polypeptide binding]; other site 749219000162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 749219000163 substrate binding site [polypeptide binding]; other site 749219000164 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 749219000165 Zn binding sites [ion binding]; other site 749219000166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 749219000167 dimer interface [polypeptide binding]; other site 749219000168 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 749219000169 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 749219000170 dimerization domain [polypeptide binding]; other site 749219000171 dimer interface [polypeptide binding]; other site 749219000172 catalytic residues [active] 749219000173 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 749219000174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219000175 RNA binding surface [nucleotide binding]; other site 749219000176 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 749219000177 active site 749219000178 uracil binding [chemical binding]; other site 749219000179 Uncharacterized conserved protein [Function unknown]; Region: COG1739 749219000180 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 749219000181 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 749219000182 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 749219000183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 749219000184 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 749219000185 active site 749219000186 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 749219000187 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 749219000188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000189 osmolarity response regulator; Provisional; Region: ompR; PRK09468 749219000190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000191 active site 749219000192 phosphorylation site [posttranslational modification] 749219000193 intermolecular recognition site; other site 749219000194 dimerization interface [polypeptide binding]; other site 749219000195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219000196 DNA binding site [nucleotide binding] 749219000197 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 749219000198 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 749219000199 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 749219000200 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 749219000201 RNA binding site [nucleotide binding]; other site 749219000202 Domain of unknown function (DUF305); Region: DUF305; cl15795 749219000203 Domain of unknown function (DUF305); Region: DUF305; cl15795 749219000204 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 749219000205 dimer interface [polypeptide binding]; other site 749219000206 Citrate synthase; Region: Citrate_synt; pfam00285 749219000207 active site 749219000208 citrylCoA binding site [chemical binding]; other site 749219000209 NADH binding [chemical binding]; other site 749219000210 cationic pore residues; other site 749219000211 oxalacetate/citrate binding site [chemical binding]; other site 749219000212 coenzyme A binding site [chemical binding]; other site 749219000213 catalytic triad [active] 749219000214 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 749219000215 Iron-sulfur protein interface; other site 749219000216 proximal quinone binding site [chemical binding]; other site 749219000217 SdhD (CybS) interface [polypeptide binding]; other site 749219000218 proximal heme binding site [chemical binding]; other site 749219000219 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 749219000220 SdhC subunit interface [polypeptide binding]; other site 749219000221 proximal heme binding site [chemical binding]; other site 749219000222 cardiolipin binding site; other site 749219000223 Iron-sulfur protein interface; other site 749219000224 proximal quinone binding site [chemical binding]; other site 749219000225 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 749219000226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000227 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749219000228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 749219000229 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 749219000230 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 749219000231 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 749219000232 TPP-binding site [chemical binding]; other site 749219000233 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 749219000234 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 749219000235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219000236 E3 interaction surface; other site 749219000237 lipoyl attachment site [posttranslational modification]; other site 749219000238 e3 binding domain; Region: E3_binding; pfam02817 749219000239 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 749219000240 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 749219000241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000242 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219000243 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 749219000244 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 749219000245 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000247 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000248 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000249 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 749219000250 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219000251 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 749219000252 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 749219000253 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 749219000254 active site 749219000255 Zn binding site [ion binding]; other site 749219000256 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 749219000257 putative catalytic site [active] 749219000258 putative metal binding site [ion binding]; other site 749219000259 putative phosphate binding site [ion binding]; other site 749219000260 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 749219000261 active site 749219000262 dimerization interface [polypeptide binding]; other site 749219000263 trigger factor; Provisional; Region: tig; PRK01490 749219000264 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 749219000265 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 749219000266 Clp protease; Region: CLP_protease; pfam00574 749219000267 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 749219000268 oligomer interface [polypeptide binding]; other site 749219000269 active site residues [active] 749219000270 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 749219000271 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 749219000272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000273 Walker A motif; other site 749219000274 ATP binding site [chemical binding]; other site 749219000275 Walker B motif; other site 749219000276 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 749219000277 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219000278 HSP70 interaction site [polypeptide binding]; other site 749219000279 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 749219000280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749219000281 substrate binding site [chemical binding]; other site 749219000282 oxyanion hole (OAH) forming residues; other site 749219000283 trimer interface [polypeptide binding]; other site 749219000284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000285 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749219000286 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749219000287 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 749219000288 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749219000289 dimer interface [polypeptide binding]; other site 749219000290 active site 749219000291 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 749219000292 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749219000293 Active Sites [active] 749219000294 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 749219000295 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749219000296 Active Sites [active] 749219000297 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 749219000298 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 749219000299 CysD dimerization site [polypeptide binding]; other site 749219000300 G1 box; other site 749219000301 putative GEF interaction site [polypeptide binding]; other site 749219000302 GTP/Mg2+ binding site [chemical binding]; other site 749219000303 Switch I region; other site 749219000304 G2 box; other site 749219000305 G3 box; other site 749219000306 Switch II region; other site 749219000307 G4 box; other site 749219000308 G5 box; other site 749219000309 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 749219000310 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 749219000311 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 749219000312 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 749219000313 ssDNA binding site; other site 749219000314 generic binding surface II; other site 749219000315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219000316 ATP binding site [chemical binding]; other site 749219000317 putative Mg++ binding site [ion binding]; other site 749219000318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219000319 nucleotide binding region [chemical binding]; other site 749219000320 ATP-binding site [chemical binding]; other site 749219000321 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749219000322 ligand binding site [chemical binding]; other site 749219000323 flexible hinge region; other site 749219000324 potential frameshift: common BLAST hit: gi|93007224|ref|YP_581661.1| secretion protein HlyD 749219000325 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219000326 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219000327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219000328 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 749219000329 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 749219000330 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 749219000331 CoA-binding site [chemical binding]; other site 749219000332 ATP-binding [chemical binding]; other site 749219000333 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 749219000334 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 749219000335 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 749219000336 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 749219000337 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 749219000338 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 749219000339 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 749219000340 Walker A motif; other site 749219000341 ATP binding site [chemical binding]; other site 749219000342 Walker B motif; other site 749219000343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219000344 putative substrate translocation pore; other site 749219000345 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 749219000346 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 749219000347 dimerization interface [polypeptide binding]; other site 749219000348 ATP binding site [chemical binding]; other site 749219000349 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 749219000350 dimerization interface [polypeptide binding]; other site 749219000351 ATP binding site [chemical binding]; other site 749219000352 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 749219000353 putative active site [active] 749219000354 catalytic triad [active] 749219000355 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 749219000356 N-acetylglutamate synthase; Validated; Region: PRK05279 749219000357 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 749219000358 putative feedback inhibition sensing region; other site 749219000359 putative nucleotide binding site [chemical binding]; other site 749219000360 putative substrate binding site [chemical binding]; other site 749219000361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219000362 Coenzyme A binding pocket [chemical binding]; other site 749219000363 Fibronectin type III-like domain; Region: Fn3-like; cl15273 749219000364 Imelysin; Region: Peptidase_M75; cl09159 749219000365 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 749219000366 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749219000367 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 749219000368 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219000369 FMN binding site [chemical binding]; other site 749219000370 active site 749219000371 catalytic residues [active] 749219000372 substrate binding site [chemical binding]; other site 749219000373 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749219000374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000375 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749219000376 Family description; Region: UvrD_C_2; cl15862 749219000377 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 749219000378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749219000379 DNA-binding site [nucleotide binding]; DNA binding site 749219000380 UTRA domain; Region: UTRA; cl01230 749219000381 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 749219000382 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 749219000383 active site 749219000384 FMN binding site [chemical binding]; other site 749219000385 substrate binding site [chemical binding]; other site 749219000386 3Fe-4S cluster binding site [ion binding]; other site 749219000387 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 749219000388 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 749219000389 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 749219000390 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 749219000391 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 749219000392 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 749219000393 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 749219000394 ribosomal protein L20; Region: rpl20; CHL00068 749219000395 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 749219000396 23S rRNA binding site [nucleotide binding]; other site 749219000397 L21 binding site [polypeptide binding]; other site 749219000398 L13 binding site [polypeptide binding]; other site 749219000399 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 749219000400 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 749219000401 Helix-turn-helix domains; Region: HTH; cl00088 749219000402 Rrf2 family protein; Region: rrf2_super; TIGR00738 749219000403 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 749219000404 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 749219000405 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 749219000406 Cytochrome c; Region: Cytochrom_C; cl11414 749219000407 Uncharacterized conserved protein [Function unknown]; Region: COG1262 749219000408 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 749219000409 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 749219000410 Cu(I) binding site [ion binding]; other site 749219000411 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 749219000412 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 749219000413 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 749219000414 dimer interface [polypeptide binding]; other site 749219000415 motif 1; other site 749219000416 active site 749219000417 motif 2; other site 749219000418 motif 3; other site 749219000419 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 749219000420 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 749219000421 putative tRNA-binding site [nucleotide binding]; other site 749219000422 B3/4 domain; Region: B3_4; cl11458 749219000423 tRNA synthetase B5 domain; Region: B5; cl08394 749219000424 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 749219000425 dimer interface [polypeptide binding]; other site 749219000426 motif 1; other site 749219000427 motif 3; other site 749219000428 motif 2; other site 749219000429 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 749219000430 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219000431 IHF - DNA interface [nucleotide binding]; other site 749219000432 IHF dimer interface [polypeptide binding]; other site 749219000433 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 749219000434 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 749219000435 FtsZ protein binding site [polypeptide binding]; other site 749219000436 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 749219000437 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 749219000438 DNA binding site [nucleotide binding] 749219000439 catalytic residue [active] 749219000440 H2TH interface [polypeptide binding]; other site 749219000441 putative catalytic residues [active] 749219000442 turnover-facilitating residue; other site 749219000443 intercalation triad [nucleotide binding]; other site 749219000444 8OG recognition residue [nucleotide binding]; other site 749219000445 putative reading head residues; other site 749219000446 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749219000447 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749219000448 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749219000449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 749219000450 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749219000451 synthetase active site [active] 749219000452 NTP binding site [chemical binding]; other site 749219000453 metal binding site [ion binding]; metal-binding site 749219000454 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 749219000455 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 749219000456 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 749219000457 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749219000458 ATP binding site [chemical binding]; other site 749219000459 Mg++ binding site [ion binding]; other site 749219000460 motif III; other site 749219000461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219000462 nucleotide binding region [chemical binding]; other site 749219000463 ATP-binding site [chemical binding]; other site 749219000464 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 749219000465 TRAM domain; Region: TRAM; cl01282 749219000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 749219000467 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 749219000468 active site 749219000469 catalytic site [active] 749219000470 substrate binding site [chemical binding]; other site 749219000471 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 749219000472 cysteine synthase B; Region: cysM; TIGR01138 749219000473 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749219000474 dimer interface [polypeptide binding]; other site 749219000475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000476 catalytic residue [active] 749219000477 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 749219000478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219000479 dimer interface [polypeptide binding]; other site 749219000480 phosphorylation site [posttranslational modification] 749219000481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000482 ATP binding site [chemical binding]; other site 749219000483 Mg2+ binding site [ion binding]; other site 749219000484 G-X-G motif; other site 749219000485 Response regulator receiver domain; Region: Response_reg; pfam00072 749219000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000487 active site 749219000488 phosphorylation site [posttranslational modification] 749219000489 intermolecular recognition site; other site 749219000490 dimerization interface [polypeptide binding]; other site 749219000491 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 749219000492 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 749219000493 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 749219000494 Protein of unknown function (DUF454); Region: DUF454; cl01063 749219000495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219000496 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 749219000497 inhibitor-cofactor binding pocket; inhibition site 749219000498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000499 catalytic residue [active] 749219000500 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 749219000501 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219000502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000503 catalytic residue [active] 749219000504 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 749219000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219000508 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 749219000509 putative active site [active] 749219000510 dimerization interface [polypeptide binding]; other site 749219000511 putative tRNAtyr binding site [nucleotide binding]; other site 749219000512 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 749219000513 nudix motif; other site 749219000514 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 749219000515 putative active site [active] 749219000516 putative CoA binding site [chemical binding]; other site 749219000517 nudix motif; other site 749219000518 metal binding site [ion binding]; metal-binding site 749219000519 Oligomerisation domain; Region: Oligomerisation; cl00519 749219000520 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 749219000521 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 749219000522 active site 749219000523 (T/H)XGH motif; other site 749219000524 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 749219000525 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 749219000526 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 749219000527 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 749219000528 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749219000529 dimer interface [polypeptide binding]; other site 749219000530 ssDNA binding site [nucleotide binding]; other site 749219000531 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749219000532 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 749219000533 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 749219000534 Heme exporter protein D (CcmD); Region: CcmD; cl11475 749219000535 CcmE; Region: CcmE; cl00994 749219000536 NMT1-like family; Region: NMT1_2; cl15260 749219000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000538 dimer interface [polypeptide binding]; other site 749219000539 conserved gate region; other site 749219000540 ABC-ATPase subunit interface; other site 749219000541 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 749219000542 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 749219000543 Walker A/P-loop; other site 749219000544 ATP binding site [chemical binding]; other site 749219000545 Q-loop/lid; other site 749219000546 ABC transporter signature motif; other site 749219000547 Walker B; other site 749219000548 D-loop; other site 749219000549 H-loop/switch region; other site 749219000550 NIL domain; Region: NIL; cl09633 749219000551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219000552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749219000553 dimerization interface [polypeptide binding]; other site 749219000554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219000555 dimer interface [polypeptide binding]; other site 749219000556 phosphorylation site [posttranslational modification] 749219000557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219000558 ATP binding site [chemical binding]; other site 749219000559 G-X-G motif; other site 749219000560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749219000561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219000562 active site 749219000563 phosphorylation site [posttranslational modification] 749219000564 intermolecular recognition site; other site 749219000565 dimerization interface [polypeptide binding]; other site 749219000566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219000567 DNA binding site [nucleotide binding] 749219000568 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 749219000569 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219000570 E3 interaction surface; other site 749219000571 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219000572 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219000573 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 749219000574 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 749219000575 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 749219000576 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219000577 active site 749219000578 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 749219000579 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 749219000580 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 749219000581 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 749219000582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219000583 binding surface 749219000584 TPR motif; other site 749219000585 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 749219000586 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 749219000587 tRNA; other site 749219000588 putative tRNA binding site [nucleotide binding]; other site 749219000589 putative NADP binding site [chemical binding]; other site 749219000590 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 749219000591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000592 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 749219000593 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 749219000594 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 749219000595 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 749219000596 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 749219000597 Dot/Icm substrate protein; Region: SidE; pfam12252 749219000598 Transglycosylase SLT domain; Region: SLT_2; pfam13406 749219000599 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 749219000600 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219000601 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 749219000602 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 749219000603 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 749219000604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219000605 S-adenosylmethionine binding site [chemical binding]; other site 749219000606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219000607 S-adenosylmethionine binding site [chemical binding]; other site 749219000608 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 749219000609 Protein of unknown function (DUF808); Region: DUF808; cl01002 749219000610 Sporulation related domain; Region: SPOR; cl10051 749219000611 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 749219000612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219000613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219000614 catalytic residue [active] 749219000615 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 749219000616 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 749219000617 metal binding site [ion binding]; metal-binding site 749219000618 dimer interface [polypeptide binding]; other site 749219000619 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749219000620 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219000621 Flagellin N-methylase; Region: FliB; cl00497 749219000622 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 749219000623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219000624 Transporter associated domain; Region: CorC_HlyC; cl08393 749219000625 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 749219000626 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 749219000627 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 749219000628 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 749219000629 PhnA protein; Region: PhnA; pfam03831 749219000630 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 749219000631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219000632 inhibitor-cofactor binding pocket; inhibition site 749219000633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000634 catalytic residue [active] 749219000635 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 749219000636 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 749219000637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219000638 nucleotide binding region [chemical binding]; other site 749219000639 ATP-binding site [chemical binding]; other site 749219000640 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 749219000641 SEC-C motif; Region: SEC-C; pfam02810 749219000642 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 749219000643 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 749219000644 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 749219000645 putative active site [active] 749219000646 catalytic triad [active] 749219000647 putative dimer interface [polypeptide binding]; other site 749219000648 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219000649 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219000650 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 749219000651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000652 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219000653 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 749219000654 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749219000655 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 749219000656 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749219000657 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 749219000658 active site 749219000659 chorismate binding enzyme; Region: Chorismate_bind; cl10555 749219000660 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 749219000661 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749219000662 dimer interface [polypeptide binding]; other site 749219000663 active site 749219000664 MAEBL; Provisional; Region: PTZ00121 749219000665 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 749219000666 S17 interaction site [polypeptide binding]; other site 749219000667 S8 interaction site; other site 749219000668 16S rRNA interaction site [nucleotide binding]; other site 749219000669 streptomycin interaction site [chemical binding]; other site 749219000670 23S rRNA interaction site [nucleotide binding]; other site 749219000671 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 749219000672 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 749219000673 elongation factor G; Reviewed; Region: PRK00007 749219000674 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 749219000675 G1 box; other site 749219000676 putative GEF interaction site [polypeptide binding]; other site 749219000677 GTP/Mg2+ binding site [chemical binding]; other site 749219000678 Switch I region; other site 749219000679 G2 box; other site 749219000680 G3 box; other site 749219000681 Switch II region; other site 749219000682 G4 box; other site 749219000683 G5 box; other site 749219000684 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 749219000685 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 749219000686 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 749219000687 elongation factor Tu; Reviewed; Region: PRK00049 749219000688 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749219000689 G1 box; other site 749219000690 GEF interaction site [polypeptide binding]; other site 749219000691 GTP/Mg2+ binding site [chemical binding]; other site 749219000692 Switch I region; other site 749219000693 G2 box; other site 749219000694 G3 box; other site 749219000695 Switch II region; other site 749219000696 G4 box; other site 749219000697 G5 box; other site 749219000698 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749219000699 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 749219000700 Antibiotic Binding Site [chemical binding]; other site 749219000701 thioredoxin reductase; Provisional; Region: PRK10262 749219000702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000703 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 749219000704 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 749219000705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749219000706 active site 749219000707 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 749219000708 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 749219000709 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 749219000710 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 749219000711 shikimate binding site; other site 749219000712 NAD(P) binding site [chemical binding]; other site 749219000713 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 749219000714 substrate-cofactor binding pocket; other site 749219000715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219000716 homodimer interface [polypeptide binding]; other site 749219000717 catalytic residue [active] 749219000718 YceG-like family; Region: YceG; pfam02618 749219000719 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 749219000720 dimerization interface [polypeptide binding]; other site 749219000721 thymidylate kinase; Validated; Region: tmk; PRK00698 749219000722 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 749219000723 TMP-binding site; other site 749219000724 ATP-binding site [chemical binding]; other site 749219000725 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 749219000726 dihydrodipicolinate synthase; Region: dapA; TIGR00674 749219000727 dimer interface [polypeptide binding]; other site 749219000728 active site 749219000729 catalytic residue [active] 749219000730 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 749219000731 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 749219000732 ATP binding site [chemical binding]; other site 749219000733 active site 749219000734 substrate binding site [chemical binding]; other site 749219000735 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 749219000736 anthranilate synthase component I; Provisional; Region: PRK13565 749219000737 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 749219000738 chorismate binding enzyme; Region: Chorismate_bind; cl10555 749219000739 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 749219000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219000741 Walker A motif; other site 749219000742 ATP binding site [chemical binding]; other site 749219000743 Walker B motif; other site 749219000744 arginine finger; other site 749219000745 Predicted transcriptional regulator [Transcription]; Region: COG2378 749219000746 Helix-turn-helix domains; Region: HTH; cl00088 749219000747 WYL domain; Region: WYL; cl14852 749219000748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 749219000749 elongation factor Tu; Reviewed; Region: PRK00049 749219000750 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749219000751 G1 box; other site 749219000752 GEF interaction site [polypeptide binding]; other site 749219000753 GTP/Mg2+ binding site [chemical binding]; other site 749219000754 Switch I region; other site 749219000755 G2 box; other site 749219000756 G3 box; other site 749219000757 Switch II region; other site 749219000758 G4 box; other site 749219000759 G5 box; other site 749219000760 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749219000761 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 749219000762 Antibiotic Binding Site [chemical binding]; other site 749219000763 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 749219000764 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 749219000765 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 749219000766 putative homodimer interface [polypeptide binding]; other site 749219000767 KOW motif; Region: KOW; cl00354 749219000768 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 749219000769 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 749219000770 23S rRNA interface [nucleotide binding]; other site 749219000771 L7/L12 interface [polypeptide binding]; other site 749219000772 putative thiostrepton binding site; other site 749219000773 L25 interface [polypeptide binding]; other site 749219000774 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 749219000775 mRNA/rRNA interface [nucleotide binding]; other site 749219000776 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 749219000777 23S rRNA interface [nucleotide binding]; other site 749219000778 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 749219000779 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 749219000780 core dimer interface [polypeptide binding]; other site 749219000781 peripheral dimer interface [polypeptide binding]; other site 749219000782 L10 interface [polypeptide binding]; other site 749219000783 L11 interface [polypeptide binding]; other site 749219000784 putative EF-Tu interaction site [polypeptide binding]; other site 749219000785 putative EF-G interaction site [polypeptide binding]; other site 749219000786 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 749219000787 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 749219000788 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 749219000789 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 749219000790 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 749219000791 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 749219000792 RPB11 interaction site [polypeptide binding]; other site 749219000793 RPB12 interaction site [polypeptide binding]; other site 749219000794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 749219000795 RPB3 interaction site [polypeptide binding]; other site 749219000796 RPB1 interaction site [polypeptide binding]; other site 749219000797 RPB11 interaction site [polypeptide binding]; other site 749219000798 RPB10 interaction site [polypeptide binding]; other site 749219000799 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 749219000800 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 749219000801 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 749219000802 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 749219000803 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 749219000804 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 749219000805 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 749219000806 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 749219000807 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 749219000808 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 749219000809 DNA binding site [nucleotide binding] 749219000810 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 749219000811 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 749219000812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000813 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 749219000814 L-serine binding site [chemical binding]; other site 749219000815 ACT domain interface; other site 749219000816 glutathione reductase; Validated; Region: PRK06116 749219000817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219000819 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 749219000820 carboxy-terminal protease; Provisional; Region: PRK11186 749219000821 DDE superfamily endonuclease; Region: DDE_5; cl02413 749219000822 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 749219000823 protein binding site [polypeptide binding]; other site 749219000824 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 749219000825 Catalytic dyad [active] 749219000826 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 749219000827 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749219000828 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 749219000829 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 749219000830 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 749219000831 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 749219000832 Type III pantothenate kinase; Region: Pan_kinase; cl09130 749219000833 MAPEG family; Region: MAPEG; cl09190 749219000834 OsmC-like protein; Region: OsmC; cl00767 749219000835 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 749219000836 putative active site [active] 749219000837 Ap4A binding site [chemical binding]; other site 749219000838 nudix motif; other site 749219000839 putative metal binding site [ion binding]; other site 749219000840 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 749219000841 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 749219000842 Walker A/P-loop; other site 749219000843 ATP binding site [chemical binding]; other site 749219000844 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 749219000845 ABC transporter signature motif; other site 749219000846 Walker B; other site 749219000847 D-loop; other site 749219000848 H-loop/switch region; other site 749219000849 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 749219000850 rRNA interaction site [nucleotide binding]; other site 749219000851 S8 interaction site; other site 749219000852 putative laminin-1 binding site; other site 749219000853 elongation factor Ts; Provisional; Region: tsf; PRK09377 749219000854 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 749219000855 Elongation factor TS; Region: EF_TS; pfam00889 749219000856 Elongation factor TS; Region: EF_TS; pfam00889 749219000857 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 749219000858 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219000859 active site 749219000860 glutathione synthetase; Provisional; Region: PRK05246 749219000861 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 749219000862 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219000863 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 749219000864 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 749219000865 active site 749219000866 homodimer interface [polypeptide binding]; other site 749219000867 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 749219000868 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 749219000869 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219000870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219000871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219000872 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 749219000873 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 749219000874 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219000875 Protein of unknown function DUF45; Region: DUF45; cl00636 749219000876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219000877 Helix-turn-helix domains; Region: HTH; cl00088 749219000878 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 749219000879 dimerization interface [polypeptide binding]; other site 749219000880 peroxiredoxin; Region: AhpC; TIGR03137 749219000881 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 749219000882 dimer interface [polypeptide binding]; other site 749219000883 decamer (pentamer of dimers) interface [polypeptide binding]; other site 749219000884 catalytic triad [active] 749219000885 peroxidatic and resolving cysteines [active] 749219000886 Protein of unknown function (DUF465); Region: DUF465; cl01070 749219000887 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 749219000888 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 749219000889 catalytic residue [active] 749219000890 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 749219000891 catalytic residues [active] 749219000892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219000893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219000894 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 749219000895 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749219000896 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 749219000897 Walker A/P-loop; other site 749219000898 ATP binding site [chemical binding]; other site 749219000899 Q-loop/lid; other site 749219000900 ABC transporter signature motif; other site 749219000901 Walker B; other site 749219000902 D-loop; other site 749219000903 H-loop/switch region; other site 749219000904 TOBE domain; Region: TOBE_2; cl01440 749219000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219000906 dimer interface [polypeptide binding]; other site 749219000907 conserved gate region; other site 749219000908 putative PBP binding loops; other site 749219000909 ABC-ATPase subunit interface; other site 749219000910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749219000911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219000912 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749219000913 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 749219000914 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 749219000915 metal binding site [ion binding]; metal-binding site 749219000916 dimer interface [polypeptide binding]; other site 749219000917 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 749219000918 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 749219000919 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 749219000920 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 749219000921 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 749219000922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219000923 active site 749219000924 motif I; other site 749219000925 motif II; other site 749219000926 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749219000927 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749219000928 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 749219000929 Cell division protein FtsQ; Region: FtsQ; pfam03799 749219000930 Cell division protein FtsA; Region: FtsA; cl11496 749219000931 cell division protein FtsA; Region: ftsA; TIGR01174 749219000932 Cell division protein FtsA; Region: FtsA; cl11496 749219000933 cell division protein FtsZ; Validated; Region: PRK09330 749219000934 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 749219000935 nucleotide binding site [chemical binding]; other site 749219000936 SulA interaction site; other site 749219000937 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 749219000938 RecX family; Region: RecX; cl00936 749219000939 recombinase A; Provisional; Region: recA; PRK09354 749219000940 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 749219000941 hexamer interface [polypeptide binding]; other site 749219000942 Walker A motif; other site 749219000943 ATP binding site [chemical binding]; other site 749219000944 Walker B motif; other site 749219000945 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 749219000946 FAD binding domain; Region: FAD_binding_4; pfam01565 749219000947 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 749219000948 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 749219000949 active site 749219000950 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 749219000951 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 749219000952 putative ATP binding site [chemical binding]; other site 749219000953 putative substrate interface [chemical binding]; other site 749219000954 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 749219000955 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 749219000956 active site 749219000957 substrate binding site [chemical binding]; other site 749219000958 trimer interface [polypeptide binding]; other site 749219000959 CoA binding site [chemical binding]; other site 749219000960 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219000961 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 749219000962 lipoyl synthase; Provisional; Region: PRK05481 749219000963 ferrochelatase; Reviewed; Region: hemH; PRK00035 749219000964 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 749219000965 C-terminal domain interface [polypeptide binding]; other site 749219000966 active site 749219000967 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 749219000968 active site 749219000969 N-terminal domain interface [polypeptide binding]; other site 749219000970 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 749219000971 UGMP family protein; Validated; Region: PRK09604 749219000972 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 749219000973 hypothetical protein; Provisional; Region: PRK11281 749219000974 Repeat of unknown function (DUF1079); Region: DUF1079; pfam06435 749219000975 Repeat of unknown function (DUF1079); Region: DUF1079; pfam06435 749219000976 Repeat of unknown function (DUF1079); Region: DUF1079; pfam06435 749219000977 membrane glycoprotein; Provisional; Region: PHA03332 749219000978 YadA-like C-terminal region; Region: YadA; pfam03895 749219000979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219000980 Helix-turn-helix domains; Region: HTH; cl00088 749219000981 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 749219000982 putative dimerization interface [polypeptide binding]; other site 749219000983 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749219000984 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749219000985 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 749219000986 ferric uptake regulator; Provisional; Region: fur; PRK09462 749219000987 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749219000988 metal binding site 2 [ion binding]; metal-binding site 749219000989 putative DNA binding helix; other site 749219000990 metal binding site 1 [ion binding]; metal-binding site 749219000991 dimer interface [polypeptide binding]; other site 749219000992 structural Zn2+ binding site [ion binding]; other site 749219000993 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 749219000994 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 749219000995 Walker A motif; other site 749219000996 ATP binding site [chemical binding]; other site 749219000997 Walker B motif; other site 749219000998 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 749219000999 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219001000 catalytic residue [active] 749219001001 NAD synthetase; Provisional; Region: PRK13981 749219001002 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 749219001003 multimer interface [polypeptide binding]; other site 749219001004 active site 749219001005 catalytic triad [active] 749219001006 protein interface 1 [polypeptide binding]; other site 749219001007 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 749219001008 homodimer interface [polypeptide binding]; other site 749219001009 NAD binding pocket [chemical binding]; other site 749219001010 ATP binding pocket [chemical binding]; other site 749219001011 Mg binding site [ion binding]; other site 749219001012 active-site loop [active] 749219001013 Cell division protein ZapA; Region: ZapA; cl01146 749219001014 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 749219001015 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 749219001016 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 749219001017 active site 749219001018 Riboflavin kinase; Region: Flavokinase; cl03312 749219001019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001020 S-adenosylmethionine binding site [chemical binding]; other site 749219001021 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 749219001022 TraX protein; Region: TraX; cl05434 749219001023 primosome assembly protein PriA; Validated; Region: PRK05580 749219001024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219001025 ATP binding site [chemical binding]; other site 749219001026 putative Mg++ binding site [ion binding]; other site 749219001027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001028 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749219001029 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 749219001030 homotrimer interaction site [polypeptide binding]; other site 749219001031 putative active site [active] 749219001032 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749219001033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 749219001034 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 749219001035 metal binding triad [ion binding]; metal-binding site 749219001036 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 749219001037 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749219001038 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 749219001039 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 749219001040 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 749219001041 catalytic site [active] 749219001042 G-X2-G-X-G-K; other site 749219001043 LytB protein; Region: LYTB; cl00507 749219001044 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 749219001045 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 749219001046 DHH family; Region: DHH; pfam01368 749219001047 DHHA1 domain; Region: DHHA1; pfam02272 749219001048 Predicted membrane protein [Function unknown]; Region: COG2860 749219001049 UPF0126 domain; Region: UPF0126; pfam03458 749219001050 UPF0126 domain; Region: UPF0126; pfam03458 749219001051 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 749219001052 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 749219001053 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 749219001054 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219001055 inhibitor-cofactor binding pocket; inhibition site 749219001056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219001057 catalytic residue [active] 749219001058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001060 Restriction endonuclease [Defense mechanisms]; Region: COG3587 749219001061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219001062 ATP binding site [chemical binding]; other site 749219001063 putative Mg++ binding site [ion binding]; other site 749219001064 Restriction endonuclease [Defense mechanisms]; Region: COG3587 749219001065 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 749219001066 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219001067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219001068 catalytic residue [active] 749219001069 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 749219001070 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 749219001071 GIY-YIG motif/motif A; other site 749219001072 active site 749219001073 catalytic site [active] 749219001074 putative DNA binding site [nucleotide binding]; other site 749219001075 metal binding site [ion binding]; metal-binding site 749219001076 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 749219001077 phosphoglycolate phosphatase; Provisional; Region: PRK13222 749219001078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219001079 motif II; other site 749219001080 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219001081 putative glutamate-tRNA ligase; Provisional; Region: PLN03233 749219001082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001083 active site 749219001084 HIGH motif; other site 749219001085 nucleotide binding site [chemical binding]; other site 749219001086 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001087 active site 749219001088 KMSKS motif; other site 749219001089 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 749219001090 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 749219001091 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 749219001092 active site 749219001093 metal binding site [ion binding]; metal-binding site 749219001094 hexamer interface [polypeptide binding]; other site 749219001095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219001096 ABC-ATPase subunit interface; other site 749219001097 dimer interface [polypeptide binding]; other site 749219001098 putative PBP binding regions; other site 749219001099 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 749219001100 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 749219001101 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749219001102 metal binding site 2 [ion binding]; metal-binding site 749219001103 putative DNA binding helix; other site 749219001104 metal binding site 1 [ion binding]; metal-binding site 749219001105 dimer interface [polypeptide binding]; other site 749219001106 structural Zn2+ binding site [ion binding]; other site 749219001107 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 749219001108 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749219001109 intersubunit interface [polypeptide binding]; other site 749219001110 ATP synthase I chain; Region: ATP_synt_I; cl09170 749219001111 ATP synthase A chain; Region: ATP-synt_A; cl00413 749219001112 ATP synthase subunit C; Region: ATP-synt_C; cl00466 749219001113 Plant ATP synthase F0; Region: YMF19; cl07975 749219001114 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 749219001115 Plant ATP synthase F0; Region: YMF19; cl07975 749219001116 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 749219001117 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 749219001118 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 749219001119 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 749219001120 beta subunit interaction interface [polypeptide binding]; other site 749219001121 Walker A motif; other site 749219001122 ATP binding site [chemical binding]; other site 749219001123 Walker B motif; other site 749219001124 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749219001125 ATP synthase; Region: ATP-synt; cl00365 749219001126 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 749219001127 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 749219001128 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 749219001129 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 749219001130 alpha subunit interaction interface [polypeptide binding]; other site 749219001131 Walker A motif; other site 749219001132 ATP binding site [chemical binding]; other site 749219001133 Walker B motif; other site 749219001134 inhibitor binding site; inhibition site 749219001135 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749219001136 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 749219001137 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 749219001138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219001139 active site 749219001140 phosphorylation site [posttranslational modification] 749219001141 intermolecular recognition site; other site 749219001142 dimerization interface [polypeptide binding]; other site 749219001143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219001144 DNA binding site [nucleotide binding] 749219001145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219001146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749219001147 dimerization interface [polypeptide binding]; other site 749219001148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219001149 dimer interface [polypeptide binding]; other site 749219001150 phosphorylation site [posttranslational modification] 749219001151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001152 ATP binding site [chemical binding]; other site 749219001153 Mg2+ binding site [ion binding]; other site 749219001154 G-X-G motif; other site 749219001155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749219001156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 749219001157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219001158 dimer interface [polypeptide binding]; other site 749219001159 phosphorylation site [posttranslational modification] 749219001160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001161 ATP binding site [chemical binding]; other site 749219001162 Mg2+ binding site [ion binding]; other site 749219001163 G-X-G motif; other site 749219001164 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 749219001165 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 749219001166 RimM N-terminal domain; Region: RimM; pfam01782 749219001167 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 749219001168 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 749219001169 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 749219001170 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 749219001171 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 749219001172 Pilin (bacterial filament); Region: Pilin; pfam00114 749219001173 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 749219001174 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 749219001175 substrate binding site [chemical binding]; other site 749219001176 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 749219001177 substrate binding site [chemical binding]; other site 749219001178 ligand binding site [chemical binding]; other site 749219001179 urocanate hydratase; Provisional; Region: PRK05414 749219001180 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 749219001181 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 749219001182 active sites [active] 749219001183 tetramer interface [polypeptide binding]; other site 749219001184 Arginase family; Region: Arginase; cl00306 749219001185 imidazolonepropionase; Validated; Region: PRK09356 749219001186 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 749219001187 active site 749219001188 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 749219001189 Ligand binding site [chemical binding]; other site 749219001190 Electron transfer flavoprotein domain; Region: ETF; pfam01012 749219001191 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 749219001192 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 749219001193 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 749219001194 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749219001195 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 749219001196 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 749219001197 AMP binding site [chemical binding]; other site 749219001198 metal binding site [ion binding]; metal-binding site 749219001199 active site 749219001200 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 749219001201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749219001202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001203 TPR repeat; Region: TPR_11; pfam13414 749219001204 Sel1 repeat; Region: Sel1; cl02723 749219001205 Sel1 repeat; Region: Sel1; cl02723 749219001206 Sel1 repeat; Region: Sel1; cl02723 749219001207 Sel1 repeat; Region: Sel1; cl02723 749219001208 Sel1 repeat; Region: Sel1; cl02723 749219001209 Sel1 repeat; Region: Sel1; cl02723 749219001210 dihydroorotase; Provisional; Region: PRK08417 749219001211 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 749219001212 active site 749219001213 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 749219001214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 749219001215 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 749219001216 motif 1; other site 749219001217 dimer interface [polypeptide binding]; other site 749219001218 active site 749219001219 motif 2; other site 749219001220 motif 3; other site 749219001221 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 749219001222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001223 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 749219001224 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 749219001225 Domain of unknown function DUF20; Region: UPF0118; pfam01594 749219001226 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 749219001227 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 749219001228 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219001229 AIR carboxylase; Region: AIRC; cl00310 749219001230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749219001231 active site 749219001232 metal binding site [ion binding]; metal-binding site 749219001233 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 749219001234 active site 749219001235 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 749219001236 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 749219001237 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 749219001238 active site 749219001239 catalytic triad [active] 749219001240 oxyanion hole [active] 749219001241 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219001242 biotin synthase; Region: bioB; TIGR00433 749219001243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219001244 FeS/SAM binding site; other site 749219001245 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 749219001246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 749219001247 phosphoserine phosphatase SerB; Region: serB; TIGR00338 749219001248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219001249 motif II; other site 749219001250 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 749219001251 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 749219001252 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 749219001253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 749219001254 elongation factor P; Validated; Region: PRK00529 749219001255 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 749219001256 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 749219001257 RNA binding site [nucleotide binding]; other site 749219001258 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 749219001259 RNA binding site [nucleotide binding]; other site 749219001260 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 749219001261 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 749219001262 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 749219001263 putative ligand binding site [chemical binding]; other site 749219001264 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 749219001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 749219001266 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 749219001267 FtsH Extracellular; Region: FtsH_ext; pfam06480 749219001268 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 749219001269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001270 Walker A motif; other site 749219001271 ATP binding site [chemical binding]; other site 749219001272 Walker B motif; other site 749219001273 arginine finger; other site 749219001274 Peptidase family M41; Region: Peptidase_M41; pfam01434 749219001275 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749219001276 putative acyl-acceptor binding pocket; other site 749219001277 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 749219001278 Transglycosylase; Region: Transgly; cl07896 749219001279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219001280 heat shock protein 90; Provisional; Region: PRK05218 749219001281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219001282 ATP binding site [chemical binding]; other site 749219001283 Mg2+ binding site [ion binding]; other site 749219001284 G-X-G motif; other site 749219001285 Peptidase C13 family; Region: Peptidase_C13; cl02159 749219001286 glutamate dehydrogenase; Provisional; Region: PRK09414 749219001287 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 749219001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001289 NAD(P) binding pocket [chemical binding]; other site 749219001290 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 749219001291 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 749219001292 substrate binding site [chemical binding]; other site 749219001293 catalytic Zn binding site [ion binding]; other site 749219001294 NAD binding site [chemical binding]; other site 749219001295 structural Zn binding site [ion binding]; other site 749219001296 dimer interface [polypeptide binding]; other site 749219001297 Predicted esterase [General function prediction only]; Region: COG0627 749219001298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219001299 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 749219001300 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 749219001301 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 749219001302 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 749219001303 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749219001304 Di-iron ligands [ion binding]; other site 749219001305 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 749219001306 Helix-turn-helix domains; Region: HTH; cl00088 749219001307 amino acid transporter; Region: 2A0306; TIGR00909 749219001308 Spore germination protein; Region: Spore_permease; cl15802 749219001309 pteridine reductase; Provisional; Region: PRK09135 749219001310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001311 NAD(P) binding site [chemical binding]; other site 749219001312 active site 749219001313 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 749219001314 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 749219001315 active site 749219001316 NTP binding site [chemical binding]; other site 749219001317 metal binding triad [ion binding]; metal-binding site 749219001318 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 749219001319 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 749219001320 Malic enzyme, N-terminal domain; Region: malic; pfam00390 749219001321 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 749219001322 putative NAD(P) binding site [chemical binding]; other site 749219001323 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 749219001324 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 749219001325 dimer interface [polypeptide binding]; other site 749219001326 allosteric magnesium binding site [ion binding]; other site 749219001327 active site 749219001328 aspartate-rich active site metal binding site; other site 749219001329 Schiff base residues; other site 749219001330 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 749219001331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001332 Walker A motif; other site 749219001333 ATP binding site [chemical binding]; other site 749219001334 Walker B motif; other site 749219001335 arginine finger; other site 749219001336 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 749219001337 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 749219001338 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749219001339 dimer interface [polypeptide binding]; other site 749219001340 active site 749219001341 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 749219001342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001343 NAD(P) binding site [chemical binding]; other site 749219001344 active site 749219001345 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749219001346 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749219001347 active site 2 [active] 749219001348 active site 1 [active] 749219001349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219001350 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 749219001351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219001352 active site 749219001353 Dehydratase family; Region: ILVD_EDD; cl00340 749219001354 BCCT family transporter; Region: BCCT; cl00569 749219001355 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 749219001356 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 749219001357 HIT family signature motif; other site 749219001358 catalytic residue [active] 749219001359 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749219001360 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 749219001361 FAD binding pocket [chemical binding]; other site 749219001362 FAD binding motif [chemical binding]; other site 749219001363 phosphate binding motif [ion binding]; other site 749219001364 beta-alpha-beta structure motif; other site 749219001365 NAD binding pocket [chemical binding]; other site 749219001366 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 749219001367 homodimer interaction site [polypeptide binding]; other site 749219001368 cofactor binding site; other site 749219001369 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 749219001370 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219001371 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219001372 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 749219001373 Protein export membrane protein; Region: SecD_SecF; cl14618 749219001374 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 749219001375 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 749219001376 putative metal binding site [ion binding]; other site 749219001377 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749219001378 FAD binding domain; Region: FAD_binding_4; pfam01565 749219001379 putative protease; Provisional; Region: PRK15452 749219001380 Peptidase family U32; Region: Peptidase_U32; cl03113 749219001381 chromosome segregation protein; Provisional; Region: PRK02224 749219001382 AAA domain; Region: AAA_21; pfam13304 749219001383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001384 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 749219001385 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 749219001386 GatB domain; Region: GatB_Yqey; cl11497 749219001387 Predicted methyltransferases [General function prediction only]; Region: COG0313 749219001388 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 749219001389 Predicted GTPase [General function prediction only]; Region: COG0218 749219001390 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 749219001391 G1 box; other site 749219001392 GTP/Mg2+ binding site [chemical binding]; other site 749219001393 Switch I region; other site 749219001394 G2 box; other site 749219001395 G3 box; other site 749219001396 Switch II region; other site 749219001397 G4 box; other site 749219001398 G5 box; other site 749219001399 homoserine dehydrogenase; Provisional; Region: PRK06349 749219001400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001401 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 749219001402 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 749219001403 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 749219001404 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 749219001405 dimerization domain [polypeptide binding]; other site 749219001406 dimer interface [polypeptide binding]; other site 749219001407 catalytic residues [active] 749219001408 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 749219001409 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 749219001410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 749219001411 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 749219001412 active site 749219001413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219001414 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 749219001415 Sel1 repeat; Region: Sel1; cl02723 749219001416 Sel1 repeat; Region: Sel1; cl02723 749219001417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001418 S-adenosylmethionine binding site [chemical binding]; other site 749219001419 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 749219001420 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219001421 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 749219001422 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 749219001423 lipoprotein signal peptidase; Provisional; Region: PRK14787 749219001424 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001425 active site 749219001426 HIGH motif; other site 749219001427 nucleotide binding site [chemical binding]; other site 749219001428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749219001429 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 749219001430 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219001431 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 749219001432 active site 749219001433 KMSKS motif; other site 749219001434 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 749219001435 tRNA binding surface [nucleotide binding]; other site 749219001436 anticodon binding site; other site 749219001437 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749219001438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219001439 putative substrate translocation pore; other site 749219001440 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749219001441 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 749219001442 uracil-xanthine permease; Region: ncs2; TIGR00801 749219001443 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 749219001444 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 749219001445 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 749219001446 catalytic residues [active] 749219001447 Ferredoxin [Energy production and conversion]; Region: COG1146 749219001448 4Fe-4S binding domain; Region: Fer4; cl02805 749219001449 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 749219001450 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 749219001451 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 749219001452 amidase catalytic site [active] 749219001453 Zn binding residues [ion binding]; other site 749219001454 substrate binding site [chemical binding]; other site 749219001455 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 749219001456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001457 NAD(P) binding site [chemical binding]; other site 749219001458 active site 749219001459 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 749219001460 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 749219001461 transmembrane helices; other site 749219001462 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 749219001463 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 749219001464 HIGH motif; other site 749219001465 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219001466 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 749219001467 active site 749219001468 KMSKS motif; other site 749219001469 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 749219001470 tRNA binding surface [nucleotide binding]; other site 749219001471 anticodon binding site; other site 749219001472 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 749219001473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001474 Dam-replacing family; Region: DRP; pfam06044 749219001475 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 749219001476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001477 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 749219001478 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 749219001479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001480 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 749219001481 Walker A/P-loop; other site 749219001482 ATP binding site [chemical binding]; other site 749219001483 Q-loop/lid; other site 749219001484 ABC transporter signature motif; other site 749219001485 Walker B; other site 749219001486 D-loop; other site 749219001487 H-loop/switch region; other site 749219001488 CcmB protein; Region: CcmB; cl01016 749219001489 Predicted amidohydrolase [General function prediction only]; Region: COG0388 749219001490 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 749219001491 putative active site [active] 749219001492 catalytic triad [active] 749219001493 dimer interface [polypeptide binding]; other site 749219001494 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 749219001495 thiS-thiF/thiG interaction site; other site 749219001496 Protein of unknown function (DUF423); Region: DUF423; cl01008 749219001497 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 749219001498 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749219001499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749219001500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749219001501 DNA binding residues [nucleotide binding] 749219001502 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 749219001503 CPxP motif; other site 749219001504 YcxB-like protein; Region: YcxB; pfam14317 749219001505 seryl-tRNA synthetase; Provisional; Region: PRK05431 749219001506 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 749219001507 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 749219001508 dimer interface [polypeptide binding]; other site 749219001509 active site 749219001510 motif 1; other site 749219001511 motif 2; other site 749219001512 motif 3; other site 749219001513 transketolase; Reviewed; Region: PRK12753 749219001514 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 749219001515 TPP-binding site [chemical binding]; other site 749219001516 dimer interface [polypeptide binding]; other site 749219001517 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749219001518 PYR/PP interface [polypeptide binding]; other site 749219001519 dimer interface [polypeptide binding]; other site 749219001520 TPP binding site [chemical binding]; other site 749219001521 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749219001522 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 749219001523 putative nucleotide binding site [chemical binding]; other site 749219001524 uridine monophosphate binding site [chemical binding]; other site 749219001525 homohexameric interface [polypeptide binding]; other site 749219001526 ribosome recycling factor; Reviewed; Region: frr; PRK00083 749219001527 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 749219001528 hinge region; other site 749219001529 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 749219001530 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 749219001531 catalytic residue [active] 749219001532 putative FPP diphosphate binding site; other site 749219001533 putative FPP binding hydrophobic cleft; other site 749219001534 dimer interface [polypeptide binding]; other site 749219001535 putative IPP diphosphate binding site; other site 749219001536 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 749219001537 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 749219001538 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 749219001539 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 749219001540 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 749219001541 zinc metallopeptidase RseP; Provisional; Region: PRK10779 749219001542 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 749219001543 active site 749219001544 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 749219001545 protein binding site [polypeptide binding]; other site 749219001546 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 749219001547 protein binding site [polypeptide binding]; other site 749219001548 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 749219001549 putative substrate binding region [chemical binding]; other site 749219001550 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 749219001551 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 749219001552 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 749219001553 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 749219001554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 749219001555 Surface antigen; Region: Bac_surface_Ag; cl03097 749219001556 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 749219001557 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 749219001558 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 749219001559 trimer interface [polypeptide binding]; other site 749219001560 active site 749219001561 UDP-GlcNAc binding site [chemical binding]; other site 749219001562 lipid binding site [chemical binding]; lipid-binding site 749219001563 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 749219001564 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 749219001565 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 749219001566 active site 749219001567 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 749219001568 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 749219001569 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 749219001570 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 749219001571 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 749219001572 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 749219001573 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 749219001574 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219001575 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749219001576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 749219001577 NAD(P) binding site [chemical binding]; other site 749219001578 catalytic residues [active] 749219001579 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 749219001580 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 749219001581 LemA family; Region: LemA; cl00742 749219001582 Repair protein; Region: Repair_PSII; cl01535 749219001583 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 749219001584 Repair protein; Region: Repair_PSII; cl01535 749219001585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749219001586 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 749219001587 active site 749219001588 NTP binding site [chemical binding]; other site 749219001589 metal binding triad [ion binding]; metal-binding site 749219001590 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 749219001591 dimer interface [polypeptide binding]; other site 749219001592 FMN binding site [chemical binding]; other site 749219001593 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 749219001594 active site 749219001595 FMN binding site [chemical binding]; other site 749219001596 substrate binding site [chemical binding]; other site 749219001597 homotetramer interface [polypeptide binding]; other site 749219001598 catalytic residue [active] 749219001599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219001600 Helix-turn-helix domains; Region: HTH; cl00088 749219001601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219001602 dimerization interface [polypeptide binding]; other site 749219001603 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 749219001604 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 749219001605 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 749219001606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001607 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 749219001608 Domain of unknown function DUF20; Region: UPF0118; pfam01594 749219001609 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 749219001610 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 749219001611 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 749219001612 dimerization interface [polypeptide binding]; other site 749219001613 putative ATP binding site [chemical binding]; other site 749219001614 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 749219001615 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 749219001616 active site 749219001617 substrate binding site [chemical binding]; other site 749219001618 cosubstrate binding site; other site 749219001619 catalytic site [active] 749219001620 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 749219001621 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 749219001622 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 749219001623 HopJ type III effector protein; Region: HopJ; pfam08888 749219001624 Global regulator protein family; Region: CsrA; cl00670 749219001625 aspartate kinase; Reviewed; Region: PRK06635 749219001626 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 749219001627 putative nucleotide binding site [chemical binding]; other site 749219001628 putative catalytic residues [active] 749219001629 putative Mg ion binding site [ion binding]; other site 749219001630 putative aspartate binding site [chemical binding]; other site 749219001631 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 749219001632 putative allosteric regulatory site; other site 749219001633 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 749219001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 749219001635 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 749219001636 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 749219001637 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 749219001638 motif 1; other site 749219001639 active site 749219001640 motif 2; other site 749219001641 motif 3; other site 749219001642 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 749219001643 DHHA1 domain; Region: DHHA1; pfam02272 749219001644 adenylosuccinate lyase; Provisional; Region: PRK09285 749219001645 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 749219001646 tetramer interface [polypeptide binding]; other site 749219001647 active site 749219001648 Uncharacterized membrane protein [Function unknown]; Region: COG3949 749219001649 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 749219001650 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 749219001651 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 749219001652 homotrimer interaction site [polypeptide binding]; other site 749219001653 zinc binding site [ion binding]; other site 749219001654 CDP-binding sites; other site 749219001655 Isochorismatase family; Region: Isochorismatase; pfam00857 749219001656 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 749219001657 catalytic triad [active] 749219001658 conserved cis-peptide bond; other site 749219001659 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 749219001660 putative GSH binding site [chemical binding]; other site 749219001661 catalytic residues [active] 749219001662 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219001663 catalytic loop [active] 749219001664 iron binding site [ion binding]; other site 749219001665 chaperone protein HscA; Provisional; Region: hscA; PRK05183 749219001666 co-chaperone HscB; Provisional; Region: hscB; PRK05014 749219001667 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749219001668 HSP70 interaction site [polypeptide binding]; other site 749219001669 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 749219001670 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 749219001671 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 749219001672 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 749219001673 trimerization site [polypeptide binding]; other site 749219001674 active site 749219001675 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219001676 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 749219001677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219001678 catalytic residue [active] 749219001679 Helix-turn-helix domains; Region: HTH; cl00088 749219001680 Rrf2 family protein; Region: rrf2_super; TIGR00738 749219001681 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219001682 IHF dimer interface [polypeptide binding]; other site 749219001683 IHF - DNA interface [nucleotide binding]; other site 749219001684 SurA N-terminal domain; Region: SurA_N_3; cl07813 749219001685 periplasmic folding chaperone; Provisional; Region: PRK10788 749219001686 PPIC-type PPIASE domain; Region: Rotamase; cl08278 749219001687 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 749219001688 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 749219001689 purine monophosphate binding site [chemical binding]; other site 749219001690 dimer interface [polypeptide binding]; other site 749219001691 putative catalytic residues [active] 749219001692 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 749219001693 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 749219001694 Haemagglutinin; Region: HIM; pfam05662 749219001695 Hep_Hag; Region: Hep_Hag; pfam05658 749219001696 Hep_Hag; Region: Hep_Hag; pfam05658 749219001697 YadA-like C-terminal region; Region: YadA; pfam03895 749219001698 Helix-turn-helix domains; Region: HTH; cl00088 749219001699 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 749219001700 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749219001701 active site 749219001702 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 749219001703 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219001704 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 749219001705 Transglycosylase; Region: Transgly; cl07896 749219001706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219001707 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 749219001708 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749219001709 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219001710 metal-binding site [ion binding] 749219001711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749219001712 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 749219001713 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 749219001714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 749219001715 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 749219001716 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 749219001717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219001718 active site 749219001719 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 749219001720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749219001721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 749219001722 SCP-2 sterol transfer family; Region: SCP2; cl01225 749219001723 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 749219001724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219001725 S-adenosylmethionine binding site [chemical binding]; other site 749219001726 superoxide dismutase; Provisional; Region: PRK10925 749219001727 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 749219001728 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 749219001729 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 749219001730 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 749219001731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001732 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 749219001733 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 749219001734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219001735 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 749219001736 Transposase IS200 like; Region: Y1_Tnp; cl00848 749219001737 periplasmic protein; Provisional; Region: PRK10568 749219001738 BON domain; Region: BON; cl02771 749219001739 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219001740 NlpE N-terminal domain; Region: NlpE; cl01138 749219001741 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 749219001742 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749219001743 FtsX-like permease family; Region: FtsX; cl15850 749219001744 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 749219001745 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 749219001746 Walker A/P-loop; other site 749219001747 ATP binding site [chemical binding]; other site 749219001748 Q-loop/lid; other site 749219001749 ABC transporter signature motif; other site 749219001750 Walker B; other site 749219001751 D-loop; other site 749219001752 H-loop/switch region; other site 749219001753 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 749219001754 S-adenosylmethionine synthetase; Validated; Region: PRK05250 749219001755 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 749219001756 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 749219001757 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 749219001758 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 749219001759 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 749219001760 putative active site [active] 749219001761 putative substrate binding site [chemical binding]; other site 749219001762 catalytic site [active] 749219001763 dimer interface [polypeptide binding]; other site 749219001764 YceI-like domain; Region: YceI; cl01001 749219001765 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 749219001766 putative active site [active] 749219001767 putative metal binding site [ion binding]; other site 749219001768 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 749219001769 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 749219001770 substrate binding site [chemical binding]; other site 749219001771 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 749219001772 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219001773 active site 749219001774 HIGH motif; other site 749219001775 nucleotide binding site [chemical binding]; other site 749219001776 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 749219001777 KMSKS motif; other site 749219001778 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 749219001779 PIF1-like helicase; Region: PIF1; pfam05970 749219001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219001781 Walker A motif; other site 749219001782 ATP binding site [chemical binding]; other site 749219001783 Walker B motif; other site 749219001784 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 749219001785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 749219001786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001787 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 749219001788 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 749219001789 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 749219001790 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 749219001791 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 749219001792 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 749219001793 peptide chain release factor 2; Validated; Region: prfB; PRK00578 749219001794 RF-1 domain; Region: RF-1; cl02875 749219001795 RF-1 domain; Region: RF-1; cl02875 749219001796 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 749219001797 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 749219001798 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 749219001799 Site-specific recombinase; Region: SpecificRecomb; cl15411 749219001800 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 749219001801 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 749219001802 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749219001803 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 749219001804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749219001805 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749219001806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749219001807 DNA binding residues [nucleotide binding] 749219001808 LrgA family; Region: LrgA; cl00608 749219001809 LrgB-like family; Region: LrgB; cl00596 749219001810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 749219001811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219001812 catalytic residue [active] 749219001813 Peptidase family M48; Region: Peptidase_M48; cl12018 749219001814 GTPase HflX; Provisional; Region: PRK11058 749219001815 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 749219001816 HflX GTPase family; Region: HflX; cd01878 749219001817 G1 box; other site 749219001818 GTP/Mg2+ binding site [chemical binding]; other site 749219001819 Switch I region; other site 749219001820 G2 box; other site 749219001821 G3 box; other site 749219001822 Switch II region; other site 749219001823 G4 box; other site 749219001824 G5 box; other site 749219001825 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749219001826 dihydropteroate synthase; Region: DHPS; TIGR01496 749219001827 substrate binding pocket [chemical binding]; other site 749219001828 dimer interface [polypeptide binding]; other site 749219001829 inhibitor binding site; inhibition site 749219001830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 749219001831 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 749219001832 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 749219001833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 749219001834 catalytic residues [active] 749219001835 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 749219001836 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 749219001837 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 749219001838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219001839 oligomerization interface [polypeptide binding]; other site 749219001840 active site 749219001841 NAD+ binding site [chemical binding]; other site 749219001842 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 749219001843 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219001844 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 749219001845 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 749219001846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 749219001847 TPR motif; other site 749219001848 binding surface 749219001849 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 749219001850 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 749219001851 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219001852 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 749219001853 active site 749219001854 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 749219001855 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219001856 FMN binding site [chemical binding]; other site 749219001857 active site 749219001858 catalytic residues [active] 749219001859 substrate binding site [chemical binding]; other site 749219001860 CAAX protease self-immunity; Region: Abi; cl00558 749219001861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749219001862 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 749219001863 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 749219001864 active site 749219001865 substrate binding site [chemical binding]; other site 749219001866 metal binding site [ion binding]; metal-binding site 749219001867 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 749219001868 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749219001869 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 749219001870 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 749219001871 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 749219001872 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219001873 metal-binding site [ion binding] 749219001874 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 749219001875 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 749219001876 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 749219001877 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 749219001878 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 749219001879 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 749219001880 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749219001881 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 749219001882 YdjC-like protein; Region: YdjC; cl01344 749219001883 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 749219001884 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 749219001885 putative dimer interface [polypeptide binding]; other site 749219001886 [2Fe-2S] cluster binding site [ion binding]; other site 749219001887 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 749219001888 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 749219001889 SLBB domain; Region: SLBB; pfam10531 749219001890 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 749219001891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219001892 catalytic loop [active] 749219001893 iron binding site [ion binding]; other site 749219001894 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 749219001895 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 749219001896 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 749219001897 [4Fe-4S] binding site [ion binding]; other site 749219001898 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 749219001899 NADH dehydrogenase; Region: NADHdh; cl00469 749219001900 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 749219001901 4Fe-4S binding domain; Region: Fer4; cl02805 749219001902 4Fe-4S binding domain; Region: Fer4; cl02805 749219001903 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 749219001904 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 749219001905 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 749219001906 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 749219001907 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 749219001908 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 749219001909 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 749219001910 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 749219001911 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 749219001912 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 749219001913 catalytic triad [active] 749219001914 dimer interface [polypeptide binding]; other site 749219001915 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219001916 ferredoxin-NADP reductase; Provisional; Region: PRK10926 749219001917 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 749219001918 FAD binding pocket [chemical binding]; other site 749219001919 FAD binding motif [chemical binding]; other site 749219001920 phosphate binding motif [ion binding]; other site 749219001921 beta-alpha-beta structure motif; other site 749219001922 NAD binding pocket [chemical binding]; other site 749219001923 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 749219001924 arginyl-tRNA synthetase; Region: argS; TIGR00456 749219001925 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 749219001926 active site 749219001927 HIGH motif; other site 749219001928 KMSK motif region; other site 749219001929 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 749219001930 tRNA binding surface [nucleotide binding]; other site 749219001931 anticodon binding site; other site 749219001932 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 749219001933 putative active site [active] 749219001934 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 749219001935 FAD binding domain; Region: FAD_binding_4; pfam01565 749219001936 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 749219001937 Low molecular weight phosphatase family; Region: LMWPc; cd00115 749219001938 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 749219001939 active site 749219001940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219001941 RNA binding surface [nucleotide binding]; other site 749219001942 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 749219001943 threonine dehydratase; Reviewed; Region: PRK09224 749219001944 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 749219001945 tetramer interface [polypeptide binding]; other site 749219001946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219001947 catalytic residue [active] 749219001948 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 749219001949 putative Ile/Val binding site [chemical binding]; other site 749219001950 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 749219001951 putative Ile/Val binding site [chemical binding]; other site 749219001952 Transcriptional regulator; Region: Transcrip_reg; cl00361 749219001953 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 749219001954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749219001955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219001956 FeS/SAM binding site; other site 749219001957 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 749219001958 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 749219001959 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 749219001960 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 749219001961 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 749219001962 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219001963 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 749219001964 THUMP domain; Region: THUMP; cl12076 749219001965 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 749219001966 Ligand Binding Site [chemical binding]; other site 749219001967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219001968 active site residue [active] 749219001969 potential frameshift: common BLAST hit: gi|148652574|ref|YP_001279667.1| NnrS family protein 749219001970 NnrS protein; Region: NnrS; cl01258 749219001971 NnrS protein; Region: NnrS; cl01258 749219001972 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749219001973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 749219001974 Helix-turn-helix domains; Region: HTH; cl00088 749219001975 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 749219001976 active site clefts [active] 749219001977 zinc binding site [ion binding]; other site 749219001978 dimer interface [polypeptide binding]; other site 749219001979 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 749219001980 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 749219001981 [4Fe-4S] binding site [ion binding]; other site 749219001982 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219001983 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219001984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749219001985 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 749219001986 molybdopterin cofactor binding site; other site 749219001987 nitrate reductase, beta subunit; Region: narH; TIGR01660 749219001988 4Fe-4S binding domain; Region: Fer4; cl02805 749219001989 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 749219001990 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 749219001991 PPIC-type PPIASE domain; Region: Rotamase; cl08278 749219001992 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 749219001993 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 749219001994 dimer interface [polypeptide binding]; other site 749219001995 putative functional site; other site 749219001996 putative MPT binding site; other site 749219001997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219001998 Walker A/P-loop; other site 749219001999 ATP binding site [chemical binding]; other site 749219002000 Q-loop/lid; other site 749219002001 ABC transporter signature motif; other site 749219002002 Walker B; other site 749219002003 D-loop; other site 749219002004 H-loop/switch region; other site 749219002005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002006 dimer interface [polypeptide binding]; other site 749219002007 conserved gate region; other site 749219002008 putative PBP binding loops; other site 749219002009 ABC-ATPase subunit interface; other site 749219002010 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 749219002011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219002012 TOBE domain; Region: TOBE_2; cl01440 749219002013 TOBE domain; Region: TOBE_2; cl01440 749219002014 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 749219002015 MoaE homodimer interface [polypeptide binding]; other site 749219002016 MoaD interaction [polypeptide binding]; other site 749219002017 active site residues [active] 749219002018 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 749219002019 MoaE interaction surface [polypeptide binding]; other site 749219002020 MoeB interaction surface [polypeptide binding]; other site 749219002021 thiocarboxylated glycine; other site 749219002022 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 749219002023 trimer interface [polypeptide binding]; other site 749219002024 dimer interface [polypeptide binding]; other site 749219002025 putative active site [active] 749219002026 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 749219002027 GTP binding site; other site 749219002028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 749219002029 MPT binding site; other site 749219002030 trimer interface [polypeptide binding]; other site 749219002031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 749219002032 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219002033 MOSC domain; Region: MOSC; pfam03473 749219002034 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 749219002035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219002036 FeS/SAM binding site; other site 749219002037 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 749219002038 transcriptional regulator NarL; Provisional; Region: PRK10651 749219002039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219002040 active site 749219002041 phosphorylation site [posttranslational modification] 749219002042 intermolecular recognition site; other site 749219002043 dimerization interface [polypeptide binding]; other site 749219002044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749219002045 DNA binding residues [nucleotide binding] 749219002046 dimerization interface [polypeptide binding]; other site 749219002047 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 749219002048 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 749219002049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 749219002050 Histidine kinase; Region: HisKA_3; pfam07730 749219002051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219002052 ATP binding site [chemical binding]; other site 749219002053 Mg2+ binding site [ion binding]; other site 749219002054 G-X-G motif; other site 749219002055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219002056 putative substrate translocation pore; other site 749219002057 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 749219002058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 749219002059 putative substrate translocation pore; other site 749219002060 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 749219002061 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 749219002062 ATP binding site [chemical binding]; other site 749219002063 substrate interface [chemical binding]; other site 749219002064 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002065 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002066 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002067 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 749219002068 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 749219002069 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 749219002070 potential catalytic triad [active] 749219002071 conserved cys residue [active] 749219002072 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749219002073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 749219002074 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 749219002075 tetramerization interface [polypeptide binding]; other site 749219002076 NAD(P) binding site [chemical binding]; other site 749219002077 catalytic residues [active] 749219002078 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 749219002079 peptide chain release factor 1; Validated; Region: prfA; PRK00591 749219002080 RF-1 domain; Region: RF-1; cl02875 749219002081 RF-1 domain; Region: RF-1; cl02875 749219002082 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 749219002083 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 749219002084 dimerization interface [polypeptide binding]; other site 749219002085 active site 749219002086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749219002087 Quinolinate synthetase A protein; Region: NadA; cl00420 749219002088 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 749219002089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002090 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749219002091 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 749219002092 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 749219002093 Intracellular septation protein A; Region: IspA; cl01098 749219002094 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 749219002095 Found in ATP-dependent protease La (LON); Region: LON; smart00464 749219002096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002097 Walker A motif; other site 749219002098 ATP binding site [chemical binding]; other site 749219002099 Walker B motif; other site 749219002100 arginine finger; other site 749219002101 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 749219002102 Predicted permease [General function prediction only]; Region: COG2056 749219002103 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 749219002104 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 749219002105 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 749219002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002107 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 749219002108 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 749219002109 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 749219002110 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 749219002111 dimer interface [polypeptide binding]; other site 749219002112 motif 1; other site 749219002113 active site 749219002114 motif 2; other site 749219002115 motif 3; other site 749219002116 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 749219002117 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 749219002118 GDP-binding site [chemical binding]; other site 749219002119 ACT binding site; other site 749219002120 IMP binding site; other site 749219002121 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 749219002122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 749219002123 Zn binding site [ion binding]; other site 749219002124 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749219002125 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749219002126 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 749219002127 heme binding pocket [chemical binding]; other site 749219002128 heme ligand [chemical binding]; other site 749219002129 endonuclease III; Provisional; Region: PRK10702 749219002130 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749219002131 minor groove reading motif; other site 749219002132 helix-hairpin-helix signature motif; other site 749219002133 substrate binding pocket [chemical binding]; other site 749219002134 active site 749219002135 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 749219002136 AAA domain; Region: AAA_32; pfam13654 749219002137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002138 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 749219002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219002140 S-adenosylmethionine binding site [chemical binding]; other site 749219002141 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749219002142 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749219002143 Magnesium ion binding site [ion binding]; other site 749219002144 ParB-like partition proteins; Region: parB_part; TIGR00180 749219002145 ParB-like nuclease domain; Region: ParBc; cl02129 749219002146 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 749219002147 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 749219002148 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 749219002149 Ligand binding site; other site 749219002150 oligomer interface; other site 749219002151 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749219002152 catalytic core [active] 749219002153 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 749219002154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002155 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 749219002156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 749219002157 phosphate binding site [ion binding]; other site 749219002158 L-lactate permease; Region: Lactate_perm; cl00701 749219002159 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 749219002160 putative active site [active] 749219002161 putative DNA binding site [nucleotide binding]; other site 749219002162 putative phosphate binding site [ion binding]; other site 749219002163 putative catalytic site [active] 749219002164 metal binding site A [ion binding]; metal-binding site 749219002165 putative AP binding site [nucleotide binding]; other site 749219002166 putative metal binding site B [ion binding]; other site 749219002167 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 749219002168 Helix-turn-helix domains; Region: HTH; cl00088 749219002169 GTP-binding protein YchF; Reviewed; Region: PRK09601 749219002170 YchF GTPase; Region: YchF; cd01900 749219002171 G1 box; other site 749219002172 GTP/Mg2+ binding site [chemical binding]; other site 749219002173 Switch I region; other site 749219002174 G2 box; other site 749219002175 Switch II region; other site 749219002176 G3 box; other site 749219002177 G4 box; other site 749219002178 G5 box; other site 749219002179 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 749219002180 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 749219002181 active site 749219002182 multimer interface [polypeptide binding]; other site 749219002183 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 749219002184 Predicted ATPase [General function prediction only]; Region: COG1485 749219002185 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 749219002186 putative FMN binding site [chemical binding]; other site 749219002187 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 749219002188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002189 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 749219002190 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 749219002191 catalytic core [active] 749219002192 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 749219002193 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 749219002194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002195 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 749219002196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219002197 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219002198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 749219002199 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749219002200 carboxyltransferase (CT) interaction site; other site 749219002201 biotinylation site [posttranslational modification]; other site 749219002202 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 749219002203 ribonuclease D; Region: rnd; TIGR01388 749219002204 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 749219002205 putative active site [active] 749219002206 catalytic site [active] 749219002207 putative substrate binding site [chemical binding]; other site 749219002208 HRDC domain; Region: HRDC; cl02578 749219002209 recombination protein RecR; Reviewed; Region: recR; PRK00076 749219002210 RecR protein; Region: RecR; pfam02132 749219002211 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 749219002212 putative active site [active] 749219002213 putative metal-binding site [ion binding]; other site 749219002214 tetramer interface [polypeptide binding]; other site 749219002215 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749219002216 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 749219002217 ATP cone domain; Region: ATP-cone; pfam03477 749219002218 Class I ribonucleotide reductase; Region: RNR_I; cd01679 749219002219 active site 749219002220 dimer interface [polypeptide binding]; other site 749219002221 catalytic residues [active] 749219002222 effector binding site; other site 749219002223 R2 peptide binding site; other site 749219002224 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 749219002225 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 749219002226 probable active site [active] 749219002227 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 749219002228 ScpA/B protein; Region: ScpA_ScpB; cl00598 749219002229 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 749219002230 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 749219002231 active site 749219002232 HIGH motif; other site 749219002233 dimer interface [polypeptide binding]; other site 749219002234 KMSKS motif; other site 749219002235 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 749219002236 active site 749219002237 ribulose/triose binding site [chemical binding]; other site 749219002238 phosphate binding site [ion binding]; other site 749219002239 substrate (anthranilate) binding pocket [chemical binding]; other site 749219002240 product (indole) binding pocket [chemical binding]; other site 749219002241 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 749219002242 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 749219002243 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 749219002244 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 749219002245 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 749219002246 glutamine binding [chemical binding]; other site 749219002247 catalytic triad [active] 749219002248 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 749219002249 tetramerization interface [polypeptide binding]; other site 749219002250 active site 749219002251 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 749219002252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 749219002253 putative acyl-acceptor binding pocket; other site 749219002254 ABC transporter ATPase component; Reviewed; Region: PRK11147 749219002255 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 749219002256 Walker A/P-loop; other site 749219002257 ATP binding site [chemical binding]; other site 749219002258 Q-loop/lid; other site 749219002259 ABC transporter signature motif; other site 749219002260 Walker B; other site 749219002261 D-loop; other site 749219002262 H-loop/switch region; other site 749219002263 ABC transporter; Region: ABC_tran_2; pfam12848 749219002264 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219002265 SlyX; Region: SlyX; cl01090 749219002266 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219002267 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 749219002268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749219002269 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 749219002270 ornithine carbamoyltransferase; Provisional; Region: PRK00779 749219002271 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749219002272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002273 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 749219002274 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749219002275 dimer interface [polypeptide binding]; other site 749219002276 active site 749219002277 CoA binding pocket [chemical binding]; other site 749219002278 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 749219002279 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 749219002280 ligand binding site [chemical binding]; other site 749219002281 active site 749219002282 UGI interface [polypeptide binding]; other site 749219002283 catalytic site [active] 749219002284 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749219002285 nucleoside/Zn binding site; other site 749219002286 dimer interface [polypeptide binding]; other site 749219002287 catalytic motif [active] 749219002288 cytidylate kinase; Provisional; Region: cmk; PRK00023 749219002289 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 749219002290 CMP-binding site; other site 749219002291 The sites determining sugar specificity; other site 749219002292 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 749219002293 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 749219002294 RNA binding site [nucleotide binding]; other site 749219002295 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 749219002296 RNA binding site [nucleotide binding]; other site 749219002297 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 749219002298 RNA binding site [nucleotide binding]; other site 749219002299 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 749219002300 RNA binding site [nucleotide binding]; other site 749219002301 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 749219002302 RNA binding site [nucleotide binding]; other site 749219002303 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 749219002304 RNA binding site [nucleotide binding]; other site 749219002305 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 749219002306 IHF dimer interface [polypeptide binding]; other site 749219002307 IHF - DNA interface [nucleotide binding]; other site 749219002308 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 749219002309 active site 749219002310 dimer interface [polypeptide binding]; other site 749219002311 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 749219002312 Ligand Binding Site [chemical binding]; other site 749219002313 MarC family integral membrane protein; Region: MarC; cl00919 749219002314 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 749219002315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 749219002316 YCII-related domain; Region: YCII; cl00999 749219002317 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 749219002318 ferredoxin; Provisional; Region: PRK06991 749219002319 Putative Fe-S cluster; Region: FeS; pfam04060 749219002320 4Fe-4S binding domain; Region: Fer4; cl02805 749219002321 4Fe-4S binding domain; Region: Fer4; cl02805 749219002322 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 749219002323 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 749219002324 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 749219002325 putative NADH binding site [chemical binding]; other site 749219002326 putative active site [active] 749219002327 nudix motif; other site 749219002328 putative metal binding site [ion binding]; other site 749219002329 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 749219002330 RNA/DNA hybrid binding site [nucleotide binding]; other site 749219002331 active site 749219002332 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 749219002333 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 749219002334 active site 749219002335 substrate binding site [chemical binding]; other site 749219002336 catalytic site [active] 749219002337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219002338 S-adenosylmethionine binding site [chemical binding]; other site 749219002339 HI0933-like protein; Region: HI0933_like; pfam03486 749219002340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002341 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749219002342 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 749219002343 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 749219002344 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219002345 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 749219002346 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749219002347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749219002348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219002349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219002350 Rubredoxin [Energy production and conversion]; Region: COG1773 749219002351 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 749219002352 iron binding site [ion binding]; other site 749219002353 Chorismate mutase type II; Region: CM_2; cl00693 749219002354 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 749219002355 Prephenate dehydratase; Region: PDT; pfam00800 749219002356 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 749219002357 putative L-Phe binding site [chemical binding]; other site 749219002358 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 749219002359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002360 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 749219002361 hinge; other site 749219002362 active site 749219002363 Predicted permeases [General function prediction only]; Region: RarD; COG2962 749219002364 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749219002365 active site 749219002366 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 749219002367 catalytic center binding site [active] 749219002368 ATP binding site [chemical binding]; other site 749219002369 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 749219002370 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 749219002371 dimer interface [polypeptide binding]; other site 749219002372 TPP-binding site [chemical binding]; other site 749219002373 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 749219002374 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219002375 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 749219002376 E3 interaction surface; other site 749219002377 lipoyl attachment site [posttranslational modification]; other site 749219002378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749219002379 E3 interaction surface; other site 749219002380 lipoyl attachment site [posttranslational modification]; other site 749219002381 e3 binding domain; Region: E3_binding; pfam02817 749219002382 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 749219002383 putative S-transferase; Provisional; Region: PRK11752 749219002384 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 749219002385 C-terminal domain interface [polypeptide binding]; other site 749219002386 GSH binding site (G-site) [chemical binding]; other site 749219002387 dimer interface [polypeptide binding]; other site 749219002388 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 749219002389 dimer interface [polypeptide binding]; other site 749219002390 N-terminal domain interface [polypeptide binding]; other site 749219002391 active site 749219002392 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 749219002393 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 749219002394 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 749219002395 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 749219002396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219002397 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749219002398 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 749219002399 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 749219002400 homodimer interface [polypeptide binding]; other site 749219002401 substrate-cofactor binding pocket; other site 749219002402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219002403 catalytic residue [active] 749219002404 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 749219002405 dimer interface [polypeptide binding]; other site 749219002406 putative radical transfer pathway; other site 749219002407 diiron center [ion binding]; other site 749219002408 tyrosyl radical; other site 749219002409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749219002410 catalytic loop [active] 749219002411 iron binding site [ion binding]; other site 749219002412 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 749219002413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 749219002414 dimer interface [polypeptide binding]; other site 749219002415 active site 749219002416 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219002417 catalytic residues [active] 749219002418 substrate binding site [chemical binding]; other site 749219002419 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 749219002420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002421 NAD(P) binding pocket [chemical binding]; other site 749219002422 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749219002423 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 749219002424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002425 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 749219002426 Sm1 motif; other site 749219002427 intra - hexamer interaction site; other site 749219002428 inter - hexamer interaction site [polypeptide binding]; other site 749219002429 nucleotide binding pocket [chemical binding]; other site 749219002430 Sm2 motif; other site 749219002431 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 749219002432 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 749219002433 putative active site [active] 749219002434 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 749219002435 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 749219002436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219002437 active site 749219002438 motif I; other site 749219002439 motif II; other site 749219002440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 749219002441 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 749219002442 OstA-like protein; Region: OstA; cl00844 749219002443 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 749219002444 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 749219002445 Walker A/P-loop; other site 749219002446 ATP binding site [chemical binding]; other site 749219002447 Q-loop/lid; other site 749219002448 ABC transporter signature motif; other site 749219002449 Walker B; other site 749219002450 D-loop; other site 749219002451 H-loop/switch region; other site 749219002452 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 749219002453 Proline dehydrogenase; Region: Pro_dh; cl03282 749219002454 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 749219002455 Glutamate binding site [chemical binding]; other site 749219002456 NAD binding site [chemical binding]; other site 749219002457 catalytic residues [active] 749219002458 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 749219002459 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749219002460 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749219002461 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219002462 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749219002463 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749219002464 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219002465 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 749219002466 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 749219002467 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 749219002468 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 749219002469 P loop; other site 749219002470 GTP binding site [chemical binding]; other site 749219002471 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749219002472 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749219002473 DNA binding site [nucleotide binding] 749219002474 active site 749219002475 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 749219002476 quinone interaction residues [chemical binding]; other site 749219002477 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 749219002478 active site 749219002479 catalytic residues [active] 749219002480 FMN binding site [chemical binding]; other site 749219002481 substrate binding site [chemical binding]; other site 749219002482 Colicin V production protein; Region: Colicin_V; cl00567 749219002483 amidophosphoribosyltransferase; Provisional; Region: PRK09246 749219002484 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 749219002485 active site 749219002486 tetramer interface [polypeptide binding]; other site 749219002487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219002488 active site 749219002489 Transglycosylase SLT domain; Region: SLT_2; pfam13406 749219002490 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 749219002491 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 749219002492 excinuclease ABC subunit B; Provisional; Region: PRK05298 749219002493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002494 ATP binding site [chemical binding]; other site 749219002495 putative Mg++ binding site [ion binding]; other site 749219002496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002497 nucleotide binding region [chemical binding]; other site 749219002498 ATP-binding site [chemical binding]; other site 749219002499 Ultra-violet resistance protein B; Region: UvrB; pfam12344 749219002500 UvrB/uvrC motif; Region: UVR; pfam02151 749219002501 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 749219002502 putative active site [active] 749219002503 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 749219002504 Family description; Region: UvrD_C_2; cl15862 749219002505 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 749219002506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002507 AAA domain; Region: AAA_22; pfam13401 749219002508 Family description; Region: UvrD_C_2; cl15862 749219002509 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 749219002510 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 749219002511 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749219002512 FMN binding site [chemical binding]; other site 749219002513 active site 749219002514 catalytic residues [active] 749219002515 substrate binding site [chemical binding]; other site 749219002516 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 749219002517 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 749219002518 generic binding surface II; other site 749219002519 generic binding surface I; other site 749219002520 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002521 active site 749219002522 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 749219002523 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 749219002524 Catalytic site [active] 749219002525 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 749219002526 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 749219002527 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 749219002528 BRO family, N-terminal domain; Region: Bro-N; cl10591 749219002529 ORF6C domain; Region: ORF6C; pfam10552 749219002530 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 749219002531 Phage-related protein [Function unknown]; Region: COG5412 749219002532 membrane protein P6; Region: PHA01399 749219002533 Mitotic checkpoint protein; Region: MAD; pfam05557 749219002534 Phage minor tail protein L; Region: Phage_tail_L; cl01908 749219002535 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 749219002536 MPN+ (JAMM) motif; other site 749219002537 Zinc-binding site [ion binding]; other site 749219002538 NlpC/P60 family; Region: NLPC_P60; cl11438 749219002539 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 749219002540 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749219002541 alpha-amylase; Region: PLN02361 749219002542 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749219002543 ABC-2 type transporter; Region: ABC2_membrane; cl11417 749219002544 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749219002545 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749219002546 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749219002547 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749219002548 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 749219002549 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 749219002550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002551 ATP binding site [chemical binding]; other site 749219002552 putative Mg++ binding site [ion binding]; other site 749219002553 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002554 Helicase associated domain (HA2); Region: HA2; cl04503 749219002555 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 749219002556 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 749219002557 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 749219002558 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 749219002559 Gram-negative bacterial tonB protein; Region: TonB; cl10048 749219002560 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 749219002561 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749219002562 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 749219002563 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 749219002564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219002565 ATP binding site [chemical binding]; other site 749219002566 putative Mg++ binding site [ion binding]; other site 749219002567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002568 nucleotide binding region [chemical binding]; other site 749219002569 ATP-binding site [chemical binding]; other site 749219002570 TRCF domain; Region: TRCF; cl04088 749219002571 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 749219002572 active site 749219002573 thiamine phosphate binding site [chemical binding]; other site 749219002574 pyrophosphate binding site [ion binding]; other site 749219002575 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 749219002576 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 749219002577 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 749219002578 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 749219002579 Entericidin EcnA/B family; Region: Entericidin; cl02322 749219002580 HemN family oxidoreductase; Provisional; Region: PRK05660 749219002581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219002582 FeS/SAM binding site; other site 749219002583 HemN C-terminal domain; Region: HemN_C; pfam06969 749219002584 helicase 45; Provisional; Region: PTZ00424 749219002585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749219002586 ATP binding site [chemical binding]; other site 749219002587 Mg++ binding site [ion binding]; other site 749219002588 motif III; other site 749219002589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219002590 nucleotide binding region [chemical binding]; other site 749219002591 ATP-binding site [chemical binding]; other site 749219002592 sulfate transport protein; Provisional; Region: cysT; CHL00187 749219002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002594 dimer interface [polypeptide binding]; other site 749219002595 conserved gate region; other site 749219002596 putative PBP binding loops; other site 749219002597 ABC-ATPase subunit interface; other site 749219002598 sulfate transport protein; Provisional; Region: cysT; CHL00187 749219002599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219002600 dimer interface [polypeptide binding]; other site 749219002601 conserved gate region; other site 749219002602 putative PBP binding loops; other site 749219002603 ABC-ATPase subunit interface; other site 749219002604 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 749219002605 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 749219002606 Walker A/P-loop; other site 749219002607 ATP binding site [chemical binding]; other site 749219002608 Q-loop/lid; other site 749219002609 ABC transporter signature motif; other site 749219002610 Walker B; other site 749219002611 D-loop; other site 749219002612 H-loop/switch region; other site 749219002613 DNA repair protein RadA; Provisional; Region: PRK11823 749219002614 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002615 Walker A motif; other site 749219002616 ATP binding site [chemical binding]; other site 749219002617 Walker B motif; other site 749219002618 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 749219002619 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 749219002620 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 749219002621 active site 749219002622 substrate-binding site [chemical binding]; other site 749219002623 metal-binding site [ion binding] 749219002624 GTP binding site [chemical binding]; other site 749219002625 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 749219002626 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 749219002627 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219002628 catalytic residue [active] 749219002629 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219002630 putative peptidoglycan binding site; other site 749219002631 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219002632 putative peptidoglycan binding site; other site 749219002633 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 749219002634 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219002635 putative peptidoglycan binding site; other site 749219002636 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219002637 putative peptidoglycan binding site; other site 749219002638 Domain of unknown function DUF21; Region: DUF21; pfam01595 749219002639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219002640 Preprotein translocase subunit; Region: YajC; cl00806 749219002641 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 749219002642 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 749219002643 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 749219002644 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 749219002645 Protein export membrane protein; Region: SecD_SecF; cl14618 749219002646 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 749219002647 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 749219002648 Protein export membrane protein; Region: SecD_SecF; cl14618 749219002649 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 749219002650 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219002651 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 749219002652 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 749219002653 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 749219002654 dimer interface [polypeptide binding]; other site 749219002655 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 749219002656 active site 749219002657 Fe binding site [ion binding]; other site 749219002658 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 749219002659 putative dimerization interface [polypeptide binding]; other site 749219002660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219002661 Helix-turn-helix domains; Region: HTH; cl00088 749219002662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219002663 dimerization interface [polypeptide binding]; other site 749219002664 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 749219002665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002666 Walker A motif; other site 749219002667 ATP binding site [chemical binding]; other site 749219002668 Walker B motif; other site 749219002669 arginine finger; other site 749219002670 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 749219002671 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 749219002672 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 749219002673 dimer interface [polypeptide binding]; other site 749219002674 putative anticodon binding site; other site 749219002675 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 749219002676 motif 1; other site 749219002677 active site 749219002678 motif 2; other site 749219002679 motif 3; other site 749219002680 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 749219002681 putative phosphate binding site [ion binding]; other site 749219002682 putative catalytic site [active] 749219002683 active site 749219002684 metal binding site A [ion binding]; metal-binding site 749219002685 DNA binding site [nucleotide binding] 749219002686 putative AP binding site [nucleotide binding]; other site 749219002687 putative metal binding site B [ion binding]; other site 749219002688 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749219002689 active site 749219002690 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 749219002691 tartrate dehydrogenase; Provisional; Region: PRK08194 749219002692 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 749219002693 substrate binding site [chemical binding]; other site 749219002694 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 749219002695 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 749219002696 substrate binding site [chemical binding]; other site 749219002697 ligand binding site [chemical binding]; other site 749219002698 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 749219002699 Helix-turn-helix domains; Region: HTH; cl00088 749219002700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749219002701 dimerization interface [polypeptide binding]; other site 749219002702 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 749219002703 RuvA N terminal domain; Region: RuvA_N; pfam01330 749219002704 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 749219002705 hypothetical protein; Provisional; Region: PRK08185 749219002706 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 749219002707 intersubunit interface [polypeptide binding]; other site 749219002708 active site 749219002709 zinc binding site [ion binding]; other site 749219002710 Na+ binding site [ion binding]; other site 749219002711 Phosphoglycerate kinase; Region: PGK; pfam00162 749219002712 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 749219002713 substrate binding site [chemical binding]; other site 749219002714 hinge regions; other site 749219002715 ADP binding site [chemical binding]; other site 749219002716 catalytic site [active] 749219002717 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 749219002718 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 749219002719 active site 749219002720 metal binding site [ion binding]; metal-binding site 749219002721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002722 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 749219002723 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 749219002724 replicative DNA helicase; Region: DnaB; TIGR00665 749219002725 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 749219002726 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 749219002727 Walker A motif; other site 749219002728 ATP binding site [chemical binding]; other site 749219002729 Walker B motif; other site 749219002730 DNA binding loops [nucleotide binding] 749219002731 alanine racemase; Reviewed; Region: alr; PRK00053 749219002732 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 749219002733 active site 749219002734 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219002735 substrate binding site [chemical binding]; other site 749219002736 catalytic residues [active] 749219002737 dimer interface [polypeptide binding]; other site 749219002738 MltA-interacting protein MipA; Region: MipA; cl01504 749219002739 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 749219002740 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 749219002741 heme binding site [chemical binding]; other site 749219002742 ferroxidase pore; other site 749219002743 ferroxidase diiron center [ion binding]; other site 749219002744 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 749219002745 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 749219002746 heme binding site [chemical binding]; other site 749219002747 ferroxidase pore; other site 749219002748 ferroxidase diiron center [ion binding]; other site 749219002749 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 749219002750 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 749219002751 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 749219002752 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 749219002753 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 749219002754 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 749219002755 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 749219002756 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 749219002757 homodimer interface [polypeptide binding]; other site 749219002758 NADP binding site [chemical binding]; other site 749219002759 substrate binding site [chemical binding]; other site 749219002760 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 749219002761 Clp amino terminal domain; Region: Clp_N; pfam02861 749219002762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002763 Walker A motif; other site 749219002764 ATP binding site [chemical binding]; other site 749219002765 Walker B motif; other site 749219002766 arginine finger; other site 749219002767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219002768 Walker A motif; other site 749219002769 ATP binding site [chemical binding]; other site 749219002770 Walker B motif; other site 749219002771 arginine finger; other site 749219002772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 749219002773 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 749219002774 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749219002775 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749219002776 metal-binding site [ion binding] 749219002777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749219002778 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 749219002779 Uncharacterized conserved protein [Function unknown]; Region: COG0327 749219002780 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 749219002781 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 749219002782 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 749219002783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219002784 RNA binding surface [nucleotide binding]; other site 749219002785 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 749219002786 active site 749219002787 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 749219002788 CHC2 zinc finger; Region: zf-CHC2; cl15369 749219002789 DNA primase; Validated; Region: dnaG; PRK05667 749219002790 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 749219002791 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 749219002792 active site 749219002793 metal binding site [ion binding]; metal-binding site 749219002794 interdomain interaction site; other site 749219002795 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 749219002796 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 749219002797 putative C-terminal domain interface [polypeptide binding]; other site 749219002798 putative GSH binding site (G-site) [chemical binding]; other site 749219002799 putative dimer interface [polypeptide binding]; other site 749219002800 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 749219002801 N-terminal domain interface [polypeptide binding]; other site 749219002802 dimer interface [polypeptide binding]; other site 749219002803 substrate binding pocket (H-site) [chemical binding]; other site 749219002804 DNA gyrase subunit A; Validated; Region: PRK05560 749219002805 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 749219002806 CAP-like domain; other site 749219002807 active site 749219002808 primary dimer interface [polypeptide binding]; other site 749219002809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002813 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002814 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749219002815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002816 NAD(P) binding site [chemical binding]; other site 749219002817 active site 749219002818 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 749219002819 response regulator; Provisional; Region: PRK09483 749219002820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219002821 active site 749219002822 phosphorylation site [posttranslational modification] 749219002823 intermolecular recognition site; other site 749219002824 dimerization interface [polypeptide binding]; other site 749219002825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749219002826 DNA binding residues [nucleotide binding] 749219002827 dimerization interface [polypeptide binding]; other site 749219002828 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 749219002829 C-terminal peptidase (prc); Region: prc; TIGR00225 749219002830 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 749219002831 protein binding site [polypeptide binding]; other site 749219002832 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 749219002833 Catalytic dyad [active] 749219002834 Sulfatase; Region: Sulfatase; cl10460 749219002835 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 749219002836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749219002837 Helix-turn-helix domains; Region: HTH; cl00088 749219002838 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 749219002839 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 749219002840 catalytic triad [active] 749219002841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749219002842 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749219002843 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 749219002844 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 749219002845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002846 Walker A/P-loop; other site 749219002847 ATP binding site [chemical binding]; other site 749219002848 Q-loop/lid; other site 749219002849 ABC transporter signature motif; other site 749219002850 Walker B; other site 749219002851 D-loop; other site 749219002852 H-loop/switch region; other site 749219002853 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 749219002854 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 749219002855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219002856 Walker A/P-loop; other site 749219002857 ATP binding site [chemical binding]; other site 749219002858 Q-loop/lid; other site 749219002859 ABC transporter signature motif; other site 749219002860 Walker B; other site 749219002861 D-loop; other site 749219002862 H-loop/switch region; other site 749219002863 fumarate hydratase; Reviewed; Region: fumC; PRK00485 749219002864 Class II fumarases; Region: Fumarase_classII; cd01362 749219002865 active site 749219002866 tetramer interface [polypeptide binding]; other site 749219002867 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 749219002868 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 749219002869 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 749219002870 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 749219002871 substrate binding site [chemical binding]; other site 749219002872 hexamer interface [polypeptide binding]; other site 749219002873 metal binding site [ion binding]; metal-binding site 749219002874 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 749219002875 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 749219002876 NAD binding site [chemical binding]; other site 749219002877 homotetramer interface [polypeptide binding]; other site 749219002878 homodimer interface [polypeptide binding]; other site 749219002879 substrate binding site [chemical binding]; other site 749219002880 active site 749219002881 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749219002882 active site 749219002883 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 749219002884 PLD-like domain; Region: PLDc_2; pfam13091 749219002885 putative active site [active] 749219002886 catalytic site [active] 749219002887 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 749219002888 putative active site [active] 749219002889 catalytic site [active] 749219002890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 749219002891 benzoate transport; Region: 2A0115; TIGR00895 749219002892 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 749219002893 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749219002894 active site 749219002895 dimer interface [polypeptide binding]; other site 749219002896 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 749219002897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002898 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 749219002899 glutamine synthetase; Provisional; Region: glnA; PRK09469 749219002900 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 749219002901 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749219002902 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749219002903 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 749219002904 putative metal binding site; other site 749219002905 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 749219002906 putative metal binding site; other site 749219002907 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 749219002908 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 749219002909 putative ADP-binding pocket [chemical binding]; other site 749219002910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219002911 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 749219002912 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 749219002913 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 749219002914 Walker A/P-loop; other site 749219002915 ATP binding site [chemical binding]; other site 749219002916 Q-loop/lid; other site 749219002917 ABC transporter signature motif; other site 749219002918 Walker B; other site 749219002919 D-loop; other site 749219002920 H-loop/switch region; other site 749219002921 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 749219002922 DNA-binding site [nucleotide binding]; DNA binding site 749219002923 RNA-binding motif; other site 749219002924 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 749219002925 trimer interface [polypeptide binding]; other site 749219002926 active site 749219002927 dimer interface [polypeptide binding]; other site 749219002928 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 749219002929 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 749219002930 Ligand Binding Site [chemical binding]; other site 749219002931 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 749219002932 THUMP domain; Region: THUMP; cl12076 749219002933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 749219002935 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219002936 phosphoenolpyruvate synthase; Validated; Region: PRK06464 749219002937 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 749219002938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 749219002939 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 749219002940 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 749219002941 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 749219002942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219002944 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219002945 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 749219002946 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 749219002947 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 749219002948 Substrate binding site; other site 749219002949 metal-binding site 749219002950 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749219002951 Phosphotransferase enzyme family; Region: APH; pfam01636 749219002952 OstA-like protein; Region: OstA; cl00844 749219002953 OstA-like protein; Region: OstA; cl00844 749219002954 Organic solvent tolerance protein; Region: OstA_C; pfam04453 749219002955 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 749219002956 SurA N-terminal domain; Region: SurA_N_3; cl07813 749219002957 PPIC-type PPIASE domain; Region: Rotamase; cl08278 749219002958 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 749219002959 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219002960 putative peptidoglycan binding site; other site 749219002961 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 749219002962 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 749219002963 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 749219002964 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 749219002965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219002966 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219002967 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 749219002968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749219002969 ATP-grasp domain; Region: ATP-grasp_4; cl03087 749219002970 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 749219002971 IMP binding site; other site 749219002972 dimer interface [polypeptide binding]; other site 749219002973 interdomain contacts; other site 749219002974 partial ornithine binding site; other site 749219002975 Phospholipid methyltransferase; Region: PEMT; cl00763 749219002976 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 749219002977 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 749219002978 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 749219002979 catalytic site [active] 749219002980 subunit interface [polypeptide binding]; other site 749219002981 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 749219002982 SelR domain; Region: SelR; pfam01641 749219002983 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 749219002984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749219002985 sequence-specific DNA binding site [nucleotide binding]; other site 749219002986 salt bridge; other site 749219002987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219002989 homodimer interface [polypeptide binding]; other site 749219002990 catalytic residue [active] 749219002991 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 749219002992 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749219002993 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749219002994 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 749219002995 siroheme synthase; Provisional; Region: cysG; PRK10637 749219002996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219002997 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 749219002998 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 749219002999 maleylacetoacetate isomerase; Region: maiA; TIGR01262 749219003000 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003001 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 749219003002 dimer interface [polypeptide binding]; other site 749219003003 N-terminal domain interface [polypeptide binding]; other site 749219003004 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 749219003005 Integral membrane protein TerC family; Region: TerC; cl10468 749219003006 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 749219003007 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 749219003008 homodimer interface [polypeptide binding]; other site 749219003009 substrate-cofactor binding pocket; other site 749219003010 catalytic residue [active] 749219003011 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 749219003012 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219003013 metal binding triad; other site 749219003014 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 749219003015 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219003016 metal binding triad; other site 749219003017 DsrE/DsrF-like family; Region: DrsE; cl00672 749219003018 DsrC like protein; Region: DsrC; cl01101 749219003019 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 749219003020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003021 G1 box; other site 749219003022 GTP/Mg2+ binding site [chemical binding]; other site 749219003023 G2 box; other site 749219003024 Switch I region; other site 749219003025 G3 box; other site 749219003026 Switch II region; other site 749219003027 G4 box; other site 749219003028 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 749219003029 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749219003030 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 749219003031 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 749219003032 ATP binding site [chemical binding]; other site 749219003033 substrate interface [chemical binding]; other site 749219003034 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 749219003035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003036 muropeptide transporter; Validated; Region: ampG; PRK11010 749219003037 muropeptide transporter; Validated; Region: ampG; PRK11010 749219003038 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 749219003039 Helix-turn-helix domains; Region: HTH; cl00088 749219003040 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 749219003041 substrate binding site [chemical binding]; other site 749219003042 dimerization interface [polypeptide binding]; other site 749219003043 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 749219003044 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 749219003045 transmembrane helices; other site 749219003046 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 749219003047 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 749219003048 active site 749219003049 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 749219003050 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 749219003051 dimer interface [polypeptide binding]; other site 749219003052 substrate binding site [chemical binding]; other site 749219003053 metal binding sites [ion binding]; metal-binding site 749219003054 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 749219003055 Tetramer interface [polypeptide binding]; other site 749219003056 active site 749219003057 FMN-binding site [chemical binding]; other site 749219003058 hypothetical protein; Provisional; Region: PRK01752 749219003059 SEC-C motif; Region: SEC-C; pfam02810 749219003060 polyphosphate kinase; Provisional; Region: PRK05443 749219003061 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 749219003062 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 749219003063 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749219003064 putative active site [active] 749219003065 catalytic site [active] 749219003066 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 749219003067 putative domain interface [polypeptide binding]; other site 749219003068 putative active site [active] 749219003069 catalytic site [active] 749219003070 Transglycosylase; Region: Transgly; cl07896 749219003071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003072 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 749219003073 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749219003074 substrate binding pocket [chemical binding]; other site 749219003075 chain length determination region; other site 749219003076 substrate-Mg2+ binding site; other site 749219003077 catalytic residues [active] 749219003078 aspartate-rich region 1; other site 749219003079 active site lid residues [active] 749219003080 aspartate-rich region 2; other site 749219003081 NeuB family; Region: NeuB; cl00496 749219003082 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 749219003083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 749219003084 Smr domain; Region: Smr; cl02619 749219003085 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 749219003086 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 749219003087 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 749219003088 RNA/DNA hybrid binding site [nucleotide binding]; other site 749219003089 active site 749219003090 GTP-binding protein Der; Reviewed; Region: PRK00093 749219003091 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 749219003092 G1 box; other site 749219003093 GTP/Mg2+ binding site [chemical binding]; other site 749219003094 Switch I region; other site 749219003095 G2 box; other site 749219003096 Switch II region; other site 749219003097 G3 box; other site 749219003098 G4 box; other site 749219003099 G5 box; other site 749219003100 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 749219003101 G1 box; other site 749219003102 GTP/Mg2+ binding site [chemical binding]; other site 749219003103 Switch I region; other site 749219003104 G2 box; other site 749219003105 G3 box; other site 749219003106 Switch II region; other site 749219003107 G4 box; other site 749219003108 G5 box; other site 749219003109 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 749219003110 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 749219003111 Trp docking motif [polypeptide binding]; other site 749219003112 active site 749219003113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 749219003114 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 749219003115 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 749219003116 dimer interface [polypeptide binding]; other site 749219003117 motif 1; other site 749219003118 active site 749219003119 motif 2; other site 749219003120 motif 3; other site 749219003121 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 749219003122 anticodon binding site; other site 749219003123 Protein of unknown function (DUF511); Region: DUF511; cl01114 749219003124 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 749219003125 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 749219003126 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 749219003127 TPR repeat; Region: TPR_11; pfam13414 749219003128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749219003129 binding surface 749219003130 TPR motif; other site 749219003131 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 749219003132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219003133 FeS/SAM binding site; other site 749219003134 HemK family putative methylases; Region: hemK_fam; TIGR00536 749219003135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003136 S-adenosylmethionine binding site [chemical binding]; other site 749219003137 Uncharacterized conserved protein [Function unknown]; Region: COG2850 749219003138 JmjC domain, hydroxylase; Region: JmjC; cl15814 749219003139 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 749219003140 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 749219003141 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 749219003142 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 749219003143 serine O-acetyltransferase; Region: cysE; TIGR01172 749219003144 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 749219003145 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 749219003146 trimer interface [polypeptide binding]; other site 749219003147 active site 749219003148 substrate binding site [chemical binding]; other site 749219003149 CoA binding site [chemical binding]; other site 749219003150 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 749219003151 mechanosensitive channel MscS; Provisional; Region: PRK10334 749219003152 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749219003153 short chain dehydrogenase; Provisional; Region: PRK08251 749219003154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003155 NAD(P) binding site [chemical binding]; other site 749219003156 active site 749219003157 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 749219003158 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 749219003159 tandem repeat interface [polypeptide binding]; other site 749219003160 oligomer interface [polypeptide binding]; other site 749219003161 active site residues [active] 749219003162 potassium/proton antiporter; Reviewed; Region: PRK05326 749219003163 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 749219003164 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 749219003165 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 749219003166 dimer interface [polypeptide binding]; other site 749219003167 anticodon binding site; other site 749219003168 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 749219003169 homodimer interface [polypeptide binding]; other site 749219003170 motif 1; other site 749219003171 active site 749219003172 motif 2; other site 749219003173 GAD domain; Region: GAD; pfam02938 749219003174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 749219003175 active site 749219003176 motif 3; other site 749219003177 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 749219003178 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 749219003179 putative acyl-acceptor binding pocket; other site 749219003180 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 749219003181 FMN binding site [chemical binding]; other site 749219003182 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 749219003183 dimer interface [polypeptide binding]; other site 749219003184 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 749219003185 Domain of unknown function (DUF329); Region: DUF329; cl01144 749219003186 Uncharacterized conserved protein [Function unknown]; Region: COG2966 749219003187 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 749219003188 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 749219003189 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 749219003190 Hep_Hag; Region: Hep_Hag; pfam05658 749219003191 Haemagglutinin; Region: HIM; pfam05662 749219003192 Vps51/Vps67; Region: Vps51; cl15380 749219003193 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 749219003194 Repeat of unknown function (DUF1079); Region: DUF1079; pfam06435 749219003195 YadA-like C-terminal region; Region: YadA; pfam03895 749219003196 2-isopropylmalate synthase; Validated; Region: PRK03739 749219003197 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 749219003198 active site 749219003199 catalytic residues [active] 749219003200 metal binding site [ion binding]; metal-binding site 749219003201 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 749219003202 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749219003203 Helix-turn-helix domains; Region: HTH; cl00088 749219003204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749219003205 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 749219003206 homodimer interface [polypeptide binding]; other site 749219003207 substrate-cofactor binding pocket; other site 749219003208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003209 catalytic residue [active] 749219003210 Peptidase M15; Region: Peptidase_M15_3; cl01194 749219003211 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 749219003212 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749219003213 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 749219003214 Walker A/P-loop; other site 749219003215 ATP binding site [chemical binding]; other site 749219003216 Q-loop/lid; other site 749219003217 ABC transporter signature motif; other site 749219003218 Walker B; other site 749219003219 D-loop; other site 749219003220 H-loop/switch region; other site 749219003221 NMT1/THI5 like; Region: NMT1; pfam09084 749219003222 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749219003223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003224 dimer interface [polypeptide binding]; other site 749219003225 conserved gate region; other site 749219003226 putative PBP binding loops; other site 749219003227 ABC-ATPase subunit interface; other site 749219003228 H+ Antiporter protein; Region: 2A0121; TIGR00900 749219003229 serine endoprotease; Provisional; Region: PRK10898 749219003230 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 749219003231 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749219003232 protein binding site [polypeptide binding]; other site 749219003233 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 749219003234 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 749219003235 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 749219003236 substrate binding site [chemical binding]; other site 749219003237 active site 749219003238 GTPase CgtA; Reviewed; Region: obgE; PRK12298 749219003239 GTP1/OBG; Region: GTP1_OBG; pfam01018 749219003240 Obg GTPase; Region: Obg; cd01898 749219003241 G1 box; other site 749219003242 GTP/Mg2+ binding site [chemical binding]; other site 749219003243 Switch I region; other site 749219003244 G2 box; other site 749219003245 G3 box; other site 749219003246 Switch II region; other site 749219003247 G4 box; other site 749219003248 G5 box; other site 749219003249 Predicted acetyltransferase [General function prediction only]; Region: COG3981 749219003250 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 749219003251 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 749219003252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003253 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 749219003254 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 749219003255 active site 749219003256 8-oxo-dGMP binding site [chemical binding]; other site 749219003257 nudix motif; other site 749219003258 metal binding site [ion binding]; metal-binding site 749219003259 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 749219003260 thiamine phosphate binding site [chemical binding]; other site 749219003261 active site 749219003262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 749219003263 Family of unknown function (DUF490); Region: DUF490; pfam04357 749219003264 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 749219003265 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 749219003266 Surface antigen; Region: Bac_surface_Ag; cl03097 749219003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219003268 putative substrate translocation pore; other site 749219003269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 749219003270 binding surface 749219003271 TPR motif; other site 749219003272 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749219003273 adenylate kinase; Reviewed; Region: adk; PRK00279 749219003274 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 749219003275 AMP-binding site [chemical binding]; other site 749219003276 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 749219003277 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 749219003278 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 749219003279 Cytochrome C biogenesis protein; Region: CcmH; cl01179 749219003280 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003281 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 749219003282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 749219003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003284 S-adenosylmethionine binding site [chemical binding]; other site 749219003285 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 749219003286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003287 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 749219003288 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 749219003289 active site 749219003290 homodimer interface [polypeptide binding]; other site 749219003291 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 749219003292 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 749219003293 dimerization interface 3.5A [polypeptide binding]; other site 749219003294 active site 749219003295 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 749219003296 rRNA binding site [nucleotide binding]; other site 749219003297 predicted 30S ribosome binding site; other site 749219003298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219003299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 749219003300 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 749219003301 eyelet of channel; other site 749219003302 trimer interface [polypeptide binding]; other site 749219003303 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 749219003304 active site 749219003305 dinuclear metal binding site [ion binding]; other site 749219003306 dimerization interface [polypeptide binding]; other site 749219003307 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 749219003308 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 749219003309 putative substrate binding site [chemical binding]; other site 749219003310 putative ATP binding site [chemical binding]; other site 749219003311 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 749219003312 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 749219003313 Permutation of conserved domain; other site 749219003314 active site 749219003315 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 749219003316 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749219003317 trimer interface [polypeptide binding]; other site 749219003318 active site 749219003319 LrgB-like family; Region: LrgB; cl00596 749219003320 LrgA family; Region: LrgA; cl00608 749219003321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003322 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 749219003323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219003324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749219003325 putative substrate translocation pore; other site 749219003326 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 749219003327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003328 Family description; Region: UvrD_C_2; cl15862 749219003329 GTPase RsgA; Reviewed; Region: PRK12288 749219003330 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 749219003331 GTPase/Zn-binding domain interface [polypeptide binding]; other site 749219003332 GTP/Mg2+ binding site [chemical binding]; other site 749219003333 G4 box; other site 749219003334 G5 box; other site 749219003335 G1 box; other site 749219003336 Switch I region; other site 749219003337 G2 box; other site 749219003338 G3 box; other site 749219003339 Switch II region; other site 749219003340 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219003341 active site residue [active] 749219003342 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 749219003343 GSH binding site [chemical binding]; other site 749219003344 catalytic residues [active] 749219003345 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 749219003346 SecA binding site; other site 749219003347 Preprotein binding site; other site 749219003348 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749219003349 trimer interface [polypeptide binding]; other site 749219003350 active site 749219003351 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 749219003352 nucleotide binding site [chemical binding]; other site 749219003353 Rhomboid family; Region: Rhomboid; cl11446 749219003354 Ion transport protein; Region: Ion_trans; pfam00520 749219003355 Ion channel; Region: Ion_trans_2; cl11596 749219003356 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 749219003357 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749219003358 META domain; Region: META; cl01245 749219003359 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 749219003360 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 749219003361 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 749219003362 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 749219003363 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 749219003364 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 749219003365 YcgL domain; Region: YcgL; cl01189 749219003366 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 749219003367 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749219003368 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 749219003369 lipoyl attachment site [posttranslational modification]; other site 749219003370 glycine dehydrogenase; Provisional; Region: PRK05367 749219003371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 749219003372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749219003373 catalytic residue [active] 749219003374 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 749219003375 tetramer interface [polypeptide binding]; other site 749219003376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003377 catalytic residue [active] 749219003378 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 749219003379 Carbon starvation protein CstA; Region: CstA; pfam02554 749219003380 Carbon starvation protein CstA; Region: CstA; pfam02554 749219003381 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 749219003382 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 749219003383 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 749219003384 Sodium:solute symporter family; Region: SSF; cl00456 749219003385 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 749219003386 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 749219003387 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 749219003388 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 749219003389 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 749219003390 putative metal dependent hydrolase; Provisional; Region: PRK11598 749219003391 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 749219003392 Sulfatase; Region: Sulfatase; cl10460 749219003393 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 749219003394 active site 749219003395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003396 ArsC family; Region: ArsC; pfam03960 749219003397 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 749219003398 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 749219003399 HIGH motif; other site 749219003400 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749219003401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219003402 active site 749219003403 KMSKS motif; other site 749219003404 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 749219003405 tRNA binding surface [nucleotide binding]; other site 749219003406 Lipopolysaccharide-assembly; Region: LptE; cl01125 749219003407 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 749219003408 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 749219003409 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 749219003410 eyelet of channel; other site 749219003411 trimer interface [polypeptide binding]; other site 749219003412 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 749219003413 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 749219003414 peptide binding site [polypeptide binding]; other site 749219003415 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 749219003416 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 749219003417 Walker A/P-loop; other site 749219003418 ATP binding site [chemical binding]; other site 749219003419 Q-loop/lid; other site 749219003420 ABC transporter signature motif; other site 749219003421 Walker B; other site 749219003422 D-loop; other site 749219003423 H-loop/switch region; other site 749219003424 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749219003425 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749219003426 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 749219003427 Walker A/P-loop; other site 749219003428 ATP binding site [chemical binding]; other site 749219003429 Q-loop/lid; other site 749219003430 ABC transporter signature motif; other site 749219003431 Walker B; other site 749219003432 D-loop; other site 749219003433 H-loop/switch region; other site 749219003434 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749219003435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749219003436 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 749219003437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003438 dimer interface [polypeptide binding]; other site 749219003439 conserved gate region; other site 749219003440 putative PBP binding loops; other site 749219003441 ABC-ATPase subunit interface; other site 749219003442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219003443 dimer interface [polypeptide binding]; other site 749219003444 conserved gate region; other site 749219003445 putative PBP binding loops; other site 749219003446 ABC-ATPase subunit interface; other site 749219003447 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 749219003448 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 749219003449 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 749219003450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219003451 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 749219003452 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 749219003453 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 749219003454 tandem repeat interface [polypeptide binding]; other site 749219003455 oligomer interface [polypeptide binding]; other site 749219003456 active site residues [active] 749219003457 Competence protein; Region: Competence; cl00471 749219003458 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 749219003459 substrate binding site; other site 749219003460 dimer interface; other site 749219003461 Septum formation initiator; Region: DivIC; cl11433 749219003462 enolase; Provisional; Region: eno; PRK00077 749219003463 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 749219003464 dimer interface [polypeptide binding]; other site 749219003465 metal binding site [ion binding]; metal-binding site 749219003466 substrate binding pocket [chemical binding]; other site 749219003467 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 749219003468 NeuB family; Region: NeuB; cl00496 749219003469 CTP synthetase; Validated; Region: pyrG; PRK05380 749219003470 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 749219003471 Catalytic site [active] 749219003472 active site 749219003473 UTP binding site [chemical binding]; other site 749219003474 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 749219003475 active site 749219003476 putative oxyanion hole; other site 749219003477 catalytic triad [active] 749219003478 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 749219003479 Cytochrome c; Region: Cytochrom_C; cl11414 749219003480 Cytochrome c; Region: Cytochrom_C; cl11414 749219003481 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 749219003482 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 749219003483 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 749219003484 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 749219003485 Low-spin heme binding site [chemical binding]; other site 749219003486 Putative water exit pathway; other site 749219003487 Binuclear center (active site) [active] 749219003488 Putative proton exit pathway; other site 749219003489 SCP-2 sterol transfer family; Region: SCP2; cl01225 749219003490 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 749219003491 4Fe-4S binding domain; Region: Fer4_5; pfam12801 749219003492 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 749219003493 FixH; Region: FixH; cl01254 749219003494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219003495 Helix-turn-helix domains; Region: HTH; cl00088 749219003496 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 749219003497 substrate binding pocket [chemical binding]; other site 749219003498 dimerization interface [polypeptide binding]; other site 749219003499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749219003500 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 749219003501 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 749219003502 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 749219003503 Ligand Binding Site [chemical binding]; other site 749219003504 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 749219003505 active site 749219003506 substrate binding pocket [chemical binding]; other site 749219003507 dimer interface [polypeptide binding]; other site 749219003508 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 749219003509 active site 749219003510 catalytic site [active] 749219003511 substrate binding site [chemical binding]; other site 749219003512 Protein of unknown function (DUF520); Region: DUF520; cl00723 749219003513 Cupin domain; Region: Cupin_2; cl09118 749219003514 Pirin-related protein [General function prediction only]; Region: COG1741 749219003515 Phosphate transporter family; Region: PHO4; cl00396 749219003516 Phosphate transporter family; Region: PHO4; cl00396 749219003517 UbiA prenyltransferase family; Region: UbiA; cl00337 749219003518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003519 Bacitracin resistance protein BacA; Region: BacA; cl00858 749219003520 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 749219003521 signal recognition particle protein; Provisional; Region: PRK10867 749219003522 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 749219003523 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 749219003524 P loop; other site 749219003525 GTP binding site [chemical binding]; other site 749219003526 Signal peptide binding domain; Region: SRP_SPB; pfam02978 749219003527 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 749219003528 Protein of unknown function (DUF493); Region: DUF493; cl01102 749219003529 exonuclease subunit SbcD; Provisional; Region: PRK10966 749219003530 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 749219003531 active site 749219003532 metal binding site [ion binding]; metal-binding site 749219003533 DNA binding site [nucleotide binding] 749219003534 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 749219003535 exonuclease subunit SbcC; Provisional; Region: PRK10246 749219003536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003537 Walker A/P-loop; other site 749219003538 ATP binding site [chemical binding]; other site 749219003539 Q-loop/lid; other site 749219003540 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 749219003541 exonuclease subunit SbcC; Provisional; Region: PRK10246 749219003542 exonuclease subunit SbcC; Provisional; Region: PRK10246 749219003543 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 749219003544 Q-loop/lid; other site 749219003545 ABC transporter signature motif; other site 749219003546 Walker B; other site 749219003547 D-loop; other site 749219003548 H-loop/switch region; other site 749219003549 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 749219003550 Membrane transport protein; Region: Mem_trans; cl09117 749219003551 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 749219003552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003554 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 749219003555 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 749219003556 23S rRNA interface [nucleotide binding]; other site 749219003557 L3 interface [polypeptide binding]; other site 749219003558 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 749219003559 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 749219003560 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 749219003561 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 749219003562 [2Fe-2S] cluster binding site [ion binding]; other site 749219003563 cytochrome b; Provisional; Region: CYTB; MTH00145 749219003564 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 749219003565 Qi binding site; other site 749219003566 intrachain domain interface; other site 749219003567 interchain domain interface [polypeptide binding]; other site 749219003568 heme bH binding site [chemical binding]; other site 749219003569 heme bL binding site [chemical binding]; other site 749219003570 Qo binding site; other site 749219003571 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 749219003572 interchain domain interface [polypeptide binding]; other site 749219003573 intrachain domain interface; other site 749219003574 Qi binding site; other site 749219003575 Qo binding site; other site 749219003576 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 749219003577 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 749219003578 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749219003579 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 749219003580 N-terminal domain interface [polypeptide binding]; other site 749219003581 dimer interface [polypeptide binding]; other site 749219003582 substrate binding pocket (H-site) [chemical binding]; other site 749219003583 Stringent starvation protein B; Region: SspB; cl01120 749219003584 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 749219003585 Clp amino terminal domain; Region: Clp_N; pfam02861 749219003586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219003587 Walker A motif; other site 749219003588 ATP binding site [chemical binding]; other site 749219003589 Walker B motif; other site 749219003590 arginine finger; other site 749219003591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219003592 Walker A motif; other site 749219003593 ATP binding site [chemical binding]; other site 749219003594 Walker B motif; other site 749219003595 arginine finger; other site 749219003596 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 749219003597 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 749219003598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003599 Walker A/P-loop; other site 749219003600 ATP binding site [chemical binding]; other site 749219003601 Q-loop/lid; other site 749219003602 ABC transporter signature motif; other site 749219003603 Walker B; other site 749219003604 D-loop; other site 749219003605 H-loop/switch region; other site 749219003606 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 749219003607 TM-ABC transporter signature motif; other site 749219003608 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 749219003609 zinc binding site [ion binding]; other site 749219003610 putative ligand binding site [chemical binding]; other site 749219003611 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 749219003612 zinc binding site [ion binding]; other site 749219003613 putative ligand binding site [chemical binding]; other site 749219003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219003615 S-adenosylmethionine binding site [chemical binding]; other site 749219003616 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 749219003617 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 749219003618 active site 749219003619 catalytic triad [active] 749219003620 oxyanion hole [active] 749219003621 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749219003622 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 749219003623 active site 749219003624 oxyanion hole [active] 749219003625 catalytic triad [active] 749219003626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 749219003627 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 749219003628 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 749219003629 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 749219003630 aminopeptidase N; Provisional; Region: pepN; PRK14015 749219003631 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 749219003632 Zn binding site [ion binding]; other site 749219003633 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219003634 ligand binding site [chemical binding]; other site 749219003635 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 749219003636 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 749219003637 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 749219003638 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 749219003639 substrate binding site [chemical binding]; other site 749219003640 dimerization interface [polypeptide binding]; other site 749219003641 active site 749219003642 calcium binding site [ion binding]; other site 749219003643 ribonuclease PH; Reviewed; Region: rph; PRK00173 749219003644 Ribonuclease PH; Region: RNase_PH_bact; cd11362 749219003645 hexamer interface [polypeptide binding]; other site 749219003646 active site 749219003647 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 749219003648 AMP-binding enzyme; Region: AMP-binding; cl15778 749219003649 AMP-binding enzyme; Region: AMP-binding; cl15778 749219003650 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 749219003651 AMP-binding enzyme; Region: AMP-binding; cl15778 749219003652 AMP-binding enzyme; Region: AMP-binding; cl15778 749219003653 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 749219003654 Flavoprotein; Region: Flavoprotein; cl08021 749219003655 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 749219003656 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 749219003657 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 749219003658 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 749219003659 Cytochrome c; Region: Cytochrom_C; cl11414 749219003660 Cytochrome c; Region: Cytochrom_C; cl11414 749219003661 Cytochrome c; Region: Cytochrom_C; cl11414 749219003662 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 749219003663 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 749219003664 active site 749219003665 HIGH motif; other site 749219003666 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 749219003667 KMSKS motif; other site 749219003668 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 749219003669 tRNA binding surface [nucleotide binding]; other site 749219003670 anticodon binding site; other site 749219003671 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 749219003672 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 749219003673 active site 749219003674 HIGH motif; other site 749219003675 KMSKS motif; other site 749219003676 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 749219003677 tRNA binding surface [nucleotide binding]; other site 749219003678 anticodon binding site; other site 749219003679 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 749219003680 dimer interface [polypeptide binding]; other site 749219003681 putative tRNA-binding site [nucleotide binding]; other site 749219003682 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749219003683 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749219003684 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 749219003685 ThiS interaction site; other site 749219003686 putative active site [active] 749219003687 tetramer interface [polypeptide binding]; other site 749219003688 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219003689 active site residue [active] 749219003690 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 749219003691 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 749219003692 active site 749219003693 dimerization interface [polypeptide binding]; other site 749219003694 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 749219003695 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 749219003696 TPP-binding site; other site 749219003697 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749219003698 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749219003699 PYR/PP interface [polypeptide binding]; other site 749219003700 dimer interface [polypeptide binding]; other site 749219003701 TPP binding site [chemical binding]; other site 749219003702 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749219003703 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749219003704 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 749219003705 dimerization interface [polypeptide binding]; other site 749219003706 active site 749219003707 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 749219003708 Cytochrome C'; Region: Cytochrom_C_2; cl01610 749219003709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 749219003710 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219003711 putative peptidoglycan binding site; other site 749219003712 Sporulation related domain; Region: SPOR; cl10051 749219003713 NnrS protein; Region: NnrS; cl01258 749219003714 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 749219003715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219003716 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 749219003717 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 749219003718 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 749219003719 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 749219003720 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 749219003721 substrate binding site [chemical binding]; other site 749219003722 active site 749219003723 catalytic residues [active] 749219003724 heterodimer interface [polypeptide binding]; other site 749219003725 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 749219003726 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 749219003727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219003728 catalytic residue [active] 749219003729 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 749219003730 active site 749219003731 prolyl-tRNA synthetase; Provisional; Region: PRK09194 749219003732 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 749219003733 dimer interface [polypeptide binding]; other site 749219003734 motif 1; other site 749219003735 active site 749219003736 motif 2; other site 749219003737 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 749219003738 putative deacylase active site [active] 749219003739 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 749219003740 active site 749219003741 motif 3; other site 749219003742 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 749219003743 anticodon binding site; other site 749219003744 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 749219003745 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749219003746 ABC-2 type transporter; Region: ABC2_membrane; cl11417 749219003747 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749219003748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003749 Walker A/P-loop; other site 749219003750 ATP binding site [chemical binding]; other site 749219003751 Q-loop/lid; other site 749219003752 ABC transporter signature motif; other site 749219003753 Walker B; other site 749219003754 D-loop; other site 749219003755 H-loop/switch region; other site 749219003756 Cytochrome c; Region: Cytochrom_C; cl11414 749219003757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 749219003758 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 749219003759 dimer interface [polypeptide binding]; other site 749219003760 active site 749219003761 metal binding site [ion binding]; metal-binding site 749219003762 glutathione binding site [chemical binding]; other site 749219003763 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 749219003764 active site clefts [active] 749219003765 zinc binding site [ion binding]; other site 749219003766 dimer interface [polypeptide binding]; other site 749219003767 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 749219003768 active site 749219003769 dimer interface [polypeptide binding]; other site 749219003770 metal binding site [ion binding]; metal-binding site 749219003771 shikimate kinase; Reviewed; Region: aroK; PRK00131 749219003772 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 749219003773 ADP binding site [chemical binding]; other site 749219003774 magnesium binding site [ion binding]; other site 749219003775 putative shikimate binding site; other site 749219003776 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 749219003777 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 749219003778 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 749219003779 Pilus assembly protein, PilP; Region: PilP; cl01235 749219003780 Pilus assembly protein, PilO; Region: PilO; cl01234 749219003781 Competence protein A; Region: Competence_A; pfam11104 749219003782 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 749219003783 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 749219003784 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 749219003785 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749219003786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219003787 FeS/SAM binding site; other site 749219003788 TRAM domain; Region: TRAM; cl01282 749219003789 lytic murein transglycosylase; Provisional; Region: PRK11619 749219003790 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 749219003791 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749219003792 catalytic residue [active] 749219003793 malate dehydrogenase; Provisional; Region: PRK05442 749219003794 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 749219003795 NAD(P) binding site [chemical binding]; other site 749219003796 dimer interface [polypeptide binding]; other site 749219003797 malate binding site [chemical binding]; other site 749219003798 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 749219003799 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 749219003800 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 749219003801 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 749219003802 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 749219003803 active site 749219003804 dimer interface [polypeptide binding]; other site 749219003805 motif 1; other site 749219003806 motif 2; other site 749219003807 motif 3; other site 749219003808 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 749219003809 anticodon binding site; other site 749219003810 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 749219003811 Walker A/P-loop; other site 749219003812 ATP binding site [chemical binding]; other site 749219003813 ABC transporter signature motif; other site 749219003814 Walker B; other site 749219003815 D-loop; other site 749219003816 H-loop/switch region; other site 749219003817 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 749219003818 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 749219003819 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 749219003820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749219003821 Coenzyme A binding pocket [chemical binding]; other site 749219003822 ribonuclease R; Region: RNase_R; TIGR02063 749219003823 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 749219003824 RNB domain; Region: RNB; pfam00773 749219003825 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 749219003826 RNA binding site [nucleotide binding]; other site 749219003827 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 749219003828 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 749219003829 catalytic residues [active] 749219003830 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 749219003831 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 749219003832 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 749219003833 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 749219003834 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 749219003835 FMN-binding domain; Region: FMN_bind; cl01081 749219003836 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 749219003837 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 749219003838 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 749219003839 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 749219003840 FAD binding pocket [chemical binding]; other site 749219003841 FAD binding motif [chemical binding]; other site 749219003842 phosphate binding motif [ion binding]; other site 749219003843 beta-alpha-beta structure motif; other site 749219003844 NAD binding pocket [chemical binding]; other site 749219003845 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 749219003846 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 749219003847 tetramer interface [polypeptide binding]; other site 749219003848 heme binding pocket [chemical binding]; other site 749219003849 NADPH binding site [chemical binding]; other site 749219003850 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 749219003851 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 749219003852 Flavin Reductases; Region: FlaRed; cl00801 749219003853 methionine synthase; Provisional; Region: PRK01207 749219003854 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 749219003855 substrate binding site [chemical binding]; other site 749219003856 THF binding site; other site 749219003857 zinc-binding site [ion binding]; other site 749219003858 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 749219003859 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 749219003860 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 749219003861 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 749219003862 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 749219003863 protein binding site [polypeptide binding]; other site 749219003864 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 749219003865 pseudouridine synthase; Region: TIGR00093 749219003866 active site 749219003867 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219003868 ligand binding site [chemical binding]; other site 749219003869 Rhomboid family; Region: Rhomboid; cl11446 749219003870 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 749219003871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749219003872 substrate binding site [chemical binding]; other site 749219003873 oxyanion hole (OAH) forming residues; other site 749219003874 trimer interface [polypeptide binding]; other site 749219003875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 749219003876 Protein of unknown function (DUF328); Region: DUF328; cl01143 749219003877 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 749219003878 phosphate acetyltransferase; Reviewed; Region: PRK05632 749219003879 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 749219003880 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 749219003881 propionate/acetate kinase; Provisional; Region: PRK12379 749219003882 Acetokinase family; Region: Acetate_kinase; cl01029 749219003883 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 749219003884 diaminopimelate decarboxylase; Region: lysA; TIGR01048 749219003885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 749219003886 active site 749219003887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749219003888 substrate binding site [chemical binding]; other site 749219003889 catalytic residues [active] 749219003890 dimer interface [polypeptide binding]; other site 749219003891 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 749219003892 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 749219003893 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 749219003894 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 749219003895 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749219003896 DNA binding site [nucleotide binding] 749219003897 Int/Topo IB signature motif; other site 749219003898 active site 749219003899 hypothetical protein; Provisional; Region: PRK09126 749219003900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003901 ApbE family; Region: ApbE; cl00643 749219003902 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 749219003903 folate binding site [chemical binding]; other site 749219003904 NADP+ binding site [chemical binding]; other site 749219003905 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 749219003906 dimerization interface [polypeptide binding]; other site 749219003907 active site 749219003908 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 749219003909 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 749219003910 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749219003911 ring oligomerisation interface [polypeptide binding]; other site 749219003912 ATP/Mg binding site [chemical binding]; other site 749219003913 stacking interactions; other site 749219003914 hinge regions; other site 749219003915 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 749219003916 oligomerisation interface [polypeptide binding]; other site 749219003917 mobile loop; other site 749219003918 roof hairpin; other site 749219003919 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 749219003920 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749219003921 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 749219003922 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 749219003923 hypothetical protein; Validated; Region: PRK07078 749219003924 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 749219003925 CHC2 zinc finger; Region: zf-CHC2; cl15369 749219003926 Helix-turn-helix domain; Region: HTH_39; pfam14090 749219003927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003928 integrase; Provisional; Region: PRK09692 749219003929 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 749219003930 active site 749219003931 Int/Topo IB signature motif; other site 749219003932 KWG Leptospira; Region: KWG; pfam07656 749219003933 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 749219003934 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749219003935 metal binding triad; other site 749219003936 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 749219003937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 749219003938 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749219003939 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 749219003940 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 749219003941 active site 749219003942 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 749219003943 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 749219003944 active site 749219003945 FMN binding site [chemical binding]; other site 749219003946 2,4-decadienoyl-CoA binding site; other site 749219003947 catalytic residue [active] 749219003948 4Fe-4S cluster binding site [ion binding]; other site 749219003949 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 749219003950 Mg chelatase-related protein; Region: TIGR00368 749219003951 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 749219003952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219003953 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 749219003954 ATP-dependent helicase HepA; Validated; Region: PRK04914 749219003955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749219003956 ATP binding site [chemical binding]; other site 749219003957 putative Mg++ binding site [ion binding]; other site 749219003958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749219003959 nucleotide binding region [chemical binding]; other site 749219003960 ATP-binding site [chemical binding]; other site 749219003961 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 749219003962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219003963 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749219003964 substrate binding pocket [chemical binding]; other site 749219003965 chain length determination region; other site 749219003966 substrate-Mg2+ binding site; other site 749219003967 catalytic residues [active] 749219003968 aspartate-rich region 1; other site 749219003969 active site lid residues [active] 749219003970 aspartate-rich region 2; other site 749219003971 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 749219003972 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749219003973 minor groove reading motif; other site 749219003974 helix-hairpin-helix signature motif; other site 749219003975 substrate binding pocket [chemical binding]; other site 749219003976 active site 749219003977 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 749219003978 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749219003979 nudix motif; other site 749219003980 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 749219003981 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 749219003982 active site 749219003983 substrate binding site [chemical binding]; other site 749219003984 Mg2+ binding site [ion binding]; other site 749219003985 Nitrogen regulatory protein P-II; Region: P-II; cl00412 749219003986 Nitrogen regulatory protein P-II; Region: P-II; smart00938 749219003987 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 749219003988 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219003989 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219003990 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 749219003991 multidrug efflux protein; Reviewed; Region: PRK01766 749219003992 MatE; Region: MatE; cl10513 749219003993 MatE; Region: MatE; cl10513 749219003994 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 749219003995 active site 749219003996 putative DNA-binding cleft [nucleotide binding]; other site 749219003997 dimer interface [polypeptide binding]; other site 749219003998 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 749219003999 DNA-binding site [nucleotide binding]; DNA binding site 749219004000 RNA-binding motif; other site 749219004001 ketol-acid reductoisomerase; Provisional; Region: PRK05479 749219004002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004003 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 749219004004 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 749219004005 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 749219004006 putative valine binding site [chemical binding]; other site 749219004007 dimer interface [polypeptide binding]; other site 749219004008 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 749219004009 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 749219004010 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749219004011 PYR/PP interface [polypeptide binding]; other site 749219004012 dimer interface [polypeptide binding]; other site 749219004013 TPP binding site [chemical binding]; other site 749219004014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 749219004015 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 749219004016 TPP-binding site [chemical binding]; other site 749219004017 dimer interface [polypeptide binding]; other site 749219004018 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 749219004019 BON domain; Region: BON; cl02771 749219004020 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 749219004021 putative peptidoglycan binding site; other site 749219004022 Phosphopantetheine attachment site; Region: PP-binding; cl09936 749219004023 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 749219004024 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749219004025 NAD(P) binding site [chemical binding]; other site 749219004026 homotetramer interface [polypeptide binding]; other site 749219004027 homodimer interface [polypeptide binding]; other site 749219004028 active site 749219004029 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 749219004030 Acyl transferase domain; Region: Acyl_transf_1; cl08282 749219004031 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 749219004032 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 749219004033 Protein of unknown function, DUF462; Region: DUF462; cl01190 749219004034 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 749219004035 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 749219004036 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 749219004037 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 749219004038 alphaNTD homodimer interface [polypeptide binding]; other site 749219004039 alphaNTD - beta interaction site [polypeptide binding]; other site 749219004040 alphaNTD - beta' interaction site [polypeptide binding]; other site 749219004041 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 749219004042 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 749219004043 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 749219004044 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219004045 RNA binding surface [nucleotide binding]; other site 749219004046 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 749219004047 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 749219004048 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 749219004049 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 749219004050 SecY translocase; Region: SecY; pfam00344 749219004051 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 749219004052 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 749219004053 23S rRNA binding site [nucleotide binding]; other site 749219004054 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 749219004055 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 749219004056 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 749219004057 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 749219004058 5S rRNA interface [nucleotide binding]; other site 749219004059 23S rRNA interface [nucleotide binding]; other site 749219004060 L5 interface [polypeptide binding]; other site 749219004061 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 749219004062 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749219004063 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749219004064 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 749219004065 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 749219004066 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 749219004067 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 749219004068 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 749219004069 KOW motif; Region: KOW; cl00354 749219004070 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 749219004071 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 749219004072 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 749219004073 23S rRNA interface [nucleotide binding]; other site 749219004074 putative translocon interaction site; other site 749219004075 signal recognition particle (SRP54) interaction site; other site 749219004076 L23 interface [polypeptide binding]; other site 749219004077 trigger factor interaction site; other site 749219004078 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 749219004079 23S rRNA interface [nucleotide binding]; other site 749219004080 5S rRNA interface [nucleotide binding]; other site 749219004081 putative antibiotic binding site [chemical binding]; other site 749219004082 L25 interface [polypeptide binding]; other site 749219004083 L27 interface [polypeptide binding]; other site 749219004084 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 749219004085 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 749219004086 G-X-X-G motif; other site 749219004087 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 749219004088 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 749219004089 putative translocon binding site; other site 749219004090 protein-rRNA interface [nucleotide binding]; other site 749219004091 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 749219004092 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 749219004093 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 749219004094 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 749219004095 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 749219004096 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 749219004097 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 749219004098 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 749219004099 ribonuclease G; Provisional; Region: PRK11712 749219004100 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 749219004101 homodimer interface [polypeptide binding]; other site 749219004102 oligonucleotide binding site [chemical binding]; other site 749219004103 Maf-like protein; Region: Maf; pfam02545 749219004104 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 749219004105 active site 749219004106 dimer interface [polypeptide binding]; other site 749219004107 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 749219004108 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 749219004109 Amidase; Region: Amidase; cl11426 749219004110 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219004111 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 749219004112 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 749219004113 GatB domain; Region: GatB_Yqey; cl11497 749219004114 Cytochrome c; Region: Cytochrom_C; cl11414 749219004115 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219004116 ligand binding site [chemical binding]; other site 749219004117 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 749219004118 putative acyl-acceptor binding pocket; other site 749219004119 septum formation inhibitor; Reviewed; Region: minC; PRK04804 749219004120 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 749219004121 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 749219004122 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 749219004123 Switch I; other site 749219004124 Switch II; other site 749219004125 Septum formation topological specificity factor MinE; Region: MinE; cl00538 749219004126 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 749219004127 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 749219004128 Sodium:solute symporter family; Region: SSF; cl00456 749219004129 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 749219004130 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 749219004131 5S rRNA interface [nucleotide binding]; other site 749219004132 CTC domain interface [polypeptide binding]; other site 749219004133 L16 interface [polypeptide binding]; other site 749219004134 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 749219004135 putative active site [active] 749219004136 catalytic residue [active] 749219004137 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 749219004138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749219004139 FeS/SAM binding site; other site 749219004140 HemN C-terminal domain; Region: HemN_C; pfam06969 749219004141 RDD family; Region: RDD; cl00746 749219004142 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 749219004143 dimer interface [polypeptide binding]; other site 749219004144 substrate binding site [chemical binding]; other site 749219004145 ATP binding site [chemical binding]; other site 749219004146 YGGT family; Region: YGGT; cl00508 749219004147 YGGT family; Region: YGGT; cl00508 749219004148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004149 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 749219004150 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 749219004151 Ligand Binding Site [chemical binding]; other site 749219004152 TilS substrate binding domain; Region: TilS; pfam09179 749219004153 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 749219004154 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 749219004155 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 749219004156 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 749219004157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219004158 RNA binding surface [nucleotide binding]; other site 749219004159 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 749219004160 active site 749219004161 ribonuclease E; Reviewed; Region: rne; PRK10811 749219004162 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 749219004163 homodimer interface [polypeptide binding]; other site 749219004164 oligonucleotide binding site [chemical binding]; other site 749219004165 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 749219004166 active site 749219004167 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749219004168 tetramer interface [polypeptide binding]; other site 749219004169 active site 749219004170 Mg2+/Mn2+ binding site [ion binding]; other site 749219004171 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 749219004172 UTRA domain; Region: UTRA; cl01230 749219004173 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 749219004174 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 749219004175 dimer interface [polypeptide binding]; other site 749219004176 glycine-pyridoxal phosphate binding site [chemical binding]; other site 749219004177 active site 749219004178 folate binding site [chemical binding]; other site 749219004179 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 749219004180 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 749219004181 Helix-turn-helix domain; Region: HTH_39; pfam14090 749219004182 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749219004183 Uncharacterized conserved protein [Function unknown]; Region: COG2433 749219004184 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749219004185 synthetase active site [active] 749219004186 NTP binding site [chemical binding]; other site 749219004187 metal binding site [ion binding]; metal-binding site 749219004188 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 749219004189 oligomeric interface; other site 749219004190 putative active site [active] 749219004191 homodimer interface [polypeptide binding]; other site 749219004192 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 749219004193 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 749219004194 active site 749219004195 Int/Topo IB signature motif; other site 749219004196 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749219004197 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 749219004198 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 749219004199 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 749219004200 dimer interface [polypeptide binding]; other site 749219004201 motif 1; other site 749219004202 active site 749219004203 motif 2; other site 749219004204 motif 3; other site 749219004205 PspC domain; Region: PspC; cl00864 749219004206 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 749219004207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219004208 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 749219004209 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 749219004210 HI0933-like protein; Region: HI0933_like; pfam03486 749219004211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004213 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 749219004214 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219004215 Peptidase M16C associated; Region: M16C_assoc; pfam08367 749219004216 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749219004217 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 749219004218 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 749219004219 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 749219004220 substrate binding site [chemical binding]; other site 749219004221 ATP binding site [chemical binding]; other site 749219004222 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 749219004223 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 749219004224 NifU-like domain; Region: NifU; cl00484 749219004225 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 749219004226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749219004227 active site 749219004228 nucleotide binding site [chemical binding]; other site 749219004229 HIGH motif; other site 749219004230 KMSKS motif; other site 749219004231 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749219004232 nudix motif; other site 749219004233 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 749219004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749219004236 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 749219004237 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 749219004238 acetoin reductases; Region: 23BDH; TIGR02415 749219004239 NAD binding site [chemical binding]; other site 749219004240 homotetramer interface [polypeptide binding]; other site 749219004241 homodimer interface [polypeptide binding]; other site 749219004242 active site 749219004243 substrate binding site [chemical binding]; other site 749219004244 Domain of unknown function DUF302; Region: DUF302; cl01364 749219004245 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749219004246 active site residue [active] 749219004247 LysE type translocator; Region: LysE; cl00565 749219004248 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 749219004249 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 749219004250 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 749219004251 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 749219004252 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219004253 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219004254 ABC transporter; Region: ABC_tran_2; pfam12848 749219004255 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 749219004256 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 749219004257 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 749219004258 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 749219004259 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 749219004260 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 749219004261 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 749219004262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 749219004263 ligand binding site [chemical binding]; other site 749219004264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749219004265 dimer interface [polypeptide binding]; other site 749219004266 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 749219004267 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 749219004268 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 749219004269 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 749219004270 aromatic arch; other site 749219004271 DCoH dimer interaction site [polypeptide binding]; other site 749219004272 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 749219004273 DCoH tetramer interaction site [polypeptide binding]; other site 749219004274 substrate binding site [chemical binding]; other site 749219004275 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 749219004276 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 749219004277 CAP-like domain; other site 749219004278 active site 749219004279 primary dimer interface [polypeptide binding]; other site 749219004280 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 749219004281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004282 S-adenosylmethionine binding site [chemical binding]; other site 749219004283 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 749219004284 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 749219004285 G1 box; other site 749219004286 putative GEF interaction site [polypeptide binding]; other site 749219004287 GTP/Mg2+ binding site [chemical binding]; other site 749219004288 Switch I region; other site 749219004289 G2 box; other site 749219004290 G3 box; other site 749219004291 Switch II region; other site 749219004292 G4 box; other site 749219004293 G5 box; other site 749219004294 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 749219004295 DNA polymerase I; Provisional; Region: PRK05755 749219004296 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 749219004297 active site 749219004298 metal binding site 1 [ion binding]; metal-binding site 749219004299 putative 5' ssDNA interaction site; other site 749219004300 metal binding site 3; metal-binding site 749219004301 metal binding site 2 [ion binding]; metal-binding site 749219004302 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 749219004303 putative DNA binding site [nucleotide binding]; other site 749219004304 putative metal binding site [ion binding]; other site 749219004305 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 749219004306 active site 749219004307 catalytic site [active] 749219004308 substrate binding site [chemical binding]; other site 749219004309 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 749219004310 active site 749219004311 DNA binding site [nucleotide binding] 749219004312 catalytic site [active] 749219004313 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 749219004314 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 749219004315 active site 749219004316 interdomain interaction site; other site 749219004317 putative metal-binding site [ion binding]; other site 749219004318 nucleotide binding site [chemical binding]; other site 749219004319 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 749219004320 domain I; other site 749219004321 DNA binding groove [nucleotide binding] 749219004322 phosphate binding site [ion binding]; other site 749219004323 domain II; other site 749219004324 domain III; other site 749219004325 nucleotide binding site [chemical binding]; other site 749219004326 catalytic site [active] 749219004327 domain IV; other site 749219004328 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 749219004329 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 749219004330 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 749219004331 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 749219004332 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 749219004333 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 749219004334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219004335 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 749219004336 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 749219004337 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 749219004338 Walker A/P-loop; other site 749219004339 ATP binding site [chemical binding]; other site 749219004340 Q-loop/lid; other site 749219004341 ABC transporter signature motif; other site 749219004342 Walker B; other site 749219004343 D-loop; other site 749219004344 H-loop/switch region; other site 749219004345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004347 substrate binding pocket [chemical binding]; other site 749219004348 membrane-bound complex binding site; other site 749219004349 hinge residues; other site 749219004350 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004352 substrate binding pocket [chemical binding]; other site 749219004353 membrane-bound complex binding site; other site 749219004354 hinge residues; other site 749219004355 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749219004356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749219004357 substrate binding pocket [chemical binding]; other site 749219004358 membrane-bound complex binding site; other site 749219004359 hinge residues; other site 749219004360 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 749219004361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004362 dimer interface [polypeptide binding]; other site 749219004363 conserved gate region; other site 749219004364 putative PBP binding loops; other site 749219004365 ABC-ATPase subunit interface; other site 749219004366 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 749219004367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004368 dimer interface [polypeptide binding]; other site 749219004369 conserved gate region; other site 749219004370 putative PBP binding loops; other site 749219004371 ABC-ATPase subunit interface; other site 749219004372 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 749219004373 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 749219004374 Substrate binding site; other site 749219004375 Mg++ binding site; other site 749219004376 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 749219004377 active site 749219004378 substrate binding site [chemical binding]; other site 749219004379 CoA binding site [chemical binding]; other site 749219004380 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 749219004381 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 749219004382 G1 box; other site 749219004383 putative GEF interaction site [polypeptide binding]; other site 749219004384 GTP/Mg2+ binding site [chemical binding]; other site 749219004385 Switch I region; other site 749219004386 G2 box; other site 749219004387 G3 box; other site 749219004388 Switch II region; other site 749219004389 G4 box; other site 749219004390 G5 box; other site 749219004391 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 749219004392 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 749219004393 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219004394 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749219004395 ligand binding site [chemical binding]; other site 749219004396 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 749219004397 active site 749219004398 hydrophilic channel; other site 749219004399 dimerization interface [polypeptide binding]; other site 749219004400 catalytic residues [active] 749219004401 active site lid [active] 749219004402 Recombination protein O N terminal; Region: RecO_N; cl15812 749219004403 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 749219004404 Recombination protein O C terminal; Region: RecO_C; pfam02565 749219004405 GTPase Era; Reviewed; Region: era; PRK00089 749219004406 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 749219004407 G1 box; other site 749219004408 GTP/Mg2+ binding site [chemical binding]; other site 749219004409 Switch I region; other site 749219004410 G2 box; other site 749219004411 Switch II region; other site 749219004412 G3 box; other site 749219004413 G4 box; other site 749219004414 G5 box; other site 749219004415 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 749219004416 ribonuclease III; Reviewed; Region: rnc; PRK00102 749219004417 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 749219004418 dimerization interface [polypeptide binding]; other site 749219004419 active site 749219004420 metal binding site [ion binding]; metal-binding site 749219004421 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 749219004422 dsRNA binding site [nucleotide binding]; other site 749219004423 signal peptidase I; Provisional; Region: PRK10861 749219004424 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749219004425 Catalytic site [active] 749219004426 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749219004427 GTP-binding protein LepA; Provisional; Region: PRK05433 749219004428 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 749219004429 G1 box; other site 749219004430 putative GEF interaction site [polypeptide binding]; other site 749219004431 GTP/Mg2+ binding site [chemical binding]; other site 749219004432 Switch I region; other site 749219004433 G2 box; other site 749219004434 G3 box; other site 749219004435 Switch II region; other site 749219004436 G4 box; other site 749219004437 G5 box; other site 749219004438 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 749219004439 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 749219004440 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 749219004441 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 749219004442 ferredoxin; Validated; Region: PRK07118 749219004443 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 749219004444 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 749219004445 active site 749219004446 (T/H)XGH motif; other site 749219004447 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 749219004448 dimer interface [polypeptide binding]; other site 749219004449 FMN binding site [chemical binding]; other site 749219004450 NADPH bind site [chemical binding]; other site 749219004451 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 749219004452 SmpB-tmRNA interface; other site 749219004453 His-Xaa-Ser system radical SAM maturase HsxB; Region: rSAM_paired_1; TIGR03978 749219004454 EamA-like transporter family; Region: EamA; cl01037 749219004455 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 749219004456 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 749219004457 nucleotide binding pocket [chemical binding]; other site 749219004458 K-X-D-G motif; other site 749219004459 catalytic site [active] 749219004460 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 749219004461 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 749219004462 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 749219004463 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 749219004464 Dimer interface [polypeptide binding]; other site 749219004465 BRCT sequence motif; other site 749219004466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 749219004467 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 749219004468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749219004469 active site 749219004470 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 749219004471 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 749219004472 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 749219004473 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 749219004474 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749219004475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219004476 Walker A/P-loop; other site 749219004477 ATP binding site [chemical binding]; other site 749219004478 Q-loop/lid; other site 749219004479 ABC transporter signature motif; other site 749219004480 Walker B; other site 749219004481 D-loop; other site 749219004482 H-loop/switch region; other site 749219004483 TOBE domain; Region: TOBE_2; cl01440 749219004484 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749219004485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004486 dimer interface [polypeptide binding]; other site 749219004487 conserved gate region; other site 749219004488 putative PBP binding loops; other site 749219004489 ABC-ATPase subunit interface; other site 749219004490 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749219004491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749219004492 Sulfatase; Region: Sulfatase; cl10460 749219004493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219004494 exopolyphosphatase; Provisional; Region: PRK10854 749219004495 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 749219004496 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 749219004497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749219004498 dimer interface [polypeptide binding]; other site 749219004499 phosphorylation site [posttranslational modification] 749219004500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219004501 ATP binding site [chemical binding]; other site 749219004502 Mg2+ binding site [ion binding]; other site 749219004503 G-X-G motif; other site 749219004504 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 749219004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749219004506 active site 749219004507 phosphorylation site [posttranslational modification] 749219004508 intermolecular recognition site; other site 749219004509 dimerization interface [polypeptide binding]; other site 749219004510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749219004511 DNA binding site [nucleotide binding] 749219004512 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 749219004513 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 749219004514 Walker A/P-loop; other site 749219004515 ATP binding site [chemical binding]; other site 749219004516 Q-loop/lid; other site 749219004517 ABC transporter signature motif; other site 749219004518 Walker B; other site 749219004519 D-loop; other site 749219004520 H-loop/switch region; other site 749219004521 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 749219004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749219004523 dimer interface [polypeptide binding]; other site 749219004524 conserved gate region; other site 749219004525 putative PBP binding loops; other site 749219004526 ABC-ATPase subunit interface; other site 749219004527 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 749219004528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749219004529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749219004530 Peptidase family M48; Region: Peptidase_M48; cl12018 749219004531 BolA-like protein; Region: BolA; cl00386 749219004532 high affinity sulphate transporter 1; Region: sulP; TIGR00815 749219004533 Sulfate transporter family; Region: Sulfate_transp; cl15842 749219004534 Sulfate transporter family; Region: Sulfate_transp; cl15842 749219004535 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 749219004536 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 749219004537 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 749219004538 active site 749219004539 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749219004540 catalytic residues [active] 749219004541 transcription termination factor Rho; Provisional; Region: rho; PRK09376 749219004542 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 749219004543 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 749219004544 RNA binding site [nucleotide binding]; other site 749219004545 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 749219004546 multimer interface [polypeptide binding]; other site 749219004547 Walker A motif; other site 749219004548 ATP binding site [chemical binding]; other site 749219004549 Walker B motif; other site 749219004550 OsmC-like protein; Region: OsmC; cl00767 749219004551 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 749219004552 Fumarase C-terminus; Region: Fumerase_C; cl00795 749219004553 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 749219004554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219004555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004556 homodimer interface [polypeptide binding]; other site 749219004557 catalytic residue [active] 749219004558 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 749219004559 histidinol dehydrogenase; Region: hisD; TIGR00069 749219004560 NAD binding site [chemical binding]; other site 749219004561 dimerization interface [polypeptide binding]; other site 749219004562 product binding site; other site 749219004563 substrate binding site [chemical binding]; other site 749219004564 zinc binding site [ion binding]; other site 749219004565 catalytic residues [active] 749219004566 ATP phosphoribosyltransferase; Region: HisG; cl15266 749219004567 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 749219004568 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 749219004569 hinge; other site 749219004570 active site 749219004571 BolA-like protein; Region: BolA; cl00386 749219004572 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 749219004573 BON domain; Region: BON; cl02771 749219004574 Restriction endonuclease; Region: Mrr_cat; cl00516 749219004575 RDD family; Region: RDD; cl00746 749219004576 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 749219004577 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 749219004578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 749219004579 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 749219004580 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 749219004581 RNase E interface [polypeptide binding]; other site 749219004582 trimer interface [polypeptide binding]; other site 749219004583 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 749219004584 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 749219004585 RNase E interface [polypeptide binding]; other site 749219004586 trimer interface [polypeptide binding]; other site 749219004587 active site 749219004588 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 749219004589 putative nucleic acid binding region [nucleotide binding]; other site 749219004590 G-X-X-G motif; other site 749219004591 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 749219004592 RNA binding site [nucleotide binding]; other site 749219004593 domain interface; other site 749219004594 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 749219004595 16S/18S rRNA binding site [nucleotide binding]; other site 749219004596 S13e-L30e interaction site [polypeptide binding]; other site 749219004597 25S rRNA binding site [nucleotide binding]; other site 749219004598 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 749219004599 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 749219004600 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 749219004601 RNA binding site [nucleotide binding]; other site 749219004602 active site 749219004603 Ribosome-binding factor A; Region: RBFA; cl00542 749219004604 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 749219004605 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 749219004606 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 749219004607 translation initiation factor IF-2; Validated; Region: infB; PRK05306 749219004608 translation initiation factor IF-2; Region: IF-2; TIGR00487 749219004609 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 749219004610 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 749219004611 G1 box; other site 749219004612 putative GEF interaction site [polypeptide binding]; other site 749219004613 GTP/Mg2+ binding site [chemical binding]; other site 749219004614 Switch I region; other site 749219004615 G2 box; other site 749219004616 G3 box; other site 749219004617 Switch II region; other site 749219004618 G4 box; other site 749219004619 G5 box; other site 749219004620 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 749219004621 Translation-initiation factor 2; Region: IF-2; pfam11987 749219004622 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 749219004623 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 749219004624 NusA N-terminal domain; Region: NusA_N; pfam08529 749219004625 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 749219004626 RNA binding site [nucleotide binding]; other site 749219004627 homodimer interface [polypeptide binding]; other site 749219004628 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 749219004629 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 749219004630 G-X-X-G motif; other site 749219004631 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 749219004632 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 749219004633 ribosome maturation protein RimP; Reviewed; Region: PRK00092 749219004634 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 749219004635 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 749219004636 Sm1 motif; other site 749219004637 D3 - B interaction site; other site 749219004638 D1 - D2 interaction site; other site 749219004639 Hfq - Hfq interaction site; other site 749219004640 RNA binding pocket [nucleotide binding]; other site 749219004641 Sm2 motif; other site 749219004642 Preprotein translocase SecG subunit; Region: SecG; cl09123 749219004643 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 749219004644 substrate binding site [chemical binding]; other site 749219004645 dimer interface [polypeptide binding]; other site 749219004646 catalytic triad [active] 749219004647 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 749219004648 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 749219004649 Mg++ binding site [ion binding]; other site 749219004650 putative catalytic motif [active] 749219004651 putative substrate binding site [chemical binding]; other site 749219004652 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749219004653 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 749219004654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219004655 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219004656 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 749219004657 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749219004658 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749219004659 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 749219004660 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 749219004661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 749219004662 Septum formation initiator; Region: DivIC; cl11433 749219004663 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 749219004664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004665 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 749219004666 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 749219004667 HIGH motif; other site 749219004668 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 749219004669 active site 749219004670 KMSKS motif; other site 749219004671 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 749219004672 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 749219004673 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 749219004674 putative active site [active] 749219004675 putative dimer interface [polypeptide binding]; other site 749219004676 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749219004677 active site 749219004678 substrate binding site [chemical binding]; other site 749219004679 ATP binding site [chemical binding]; other site 749219004680 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 749219004681 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 749219004682 substrate binding site [chemical binding]; other site 749219004683 glutamase interaction surface [polypeptide binding]; other site 749219004684 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 749219004685 homopentamer interface [polypeptide binding]; other site 749219004686 active site 749219004687 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 749219004688 putative RNA binding site [nucleotide binding]; other site 749219004689 thiamine monophosphate kinase; Provisional; Region: PRK05731 749219004690 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 749219004691 ATP binding site [chemical binding]; other site 749219004692 dimerization interface [polypeptide binding]; other site 749219004693 Protein of unknown function DUF262; Region: DUF262; cl14890 749219004694 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 749219004695 tetramer interfaces [polypeptide binding]; other site 749219004696 binuclear metal-binding site [ion binding]; other site 749219004697 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 749219004698 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 749219004699 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 749219004700 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 749219004701 cofactor binding site; other site 749219004702 DNA binding site [nucleotide binding] 749219004703 substrate interaction site [chemical binding]; other site 749219004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 749219004705 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 749219004706 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 749219004707 dimerization interface [polypeptide binding]; other site 749219004708 domain crossover interface; other site 749219004709 redox-dependent activation switch; other site 749219004710 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 749219004711 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 749219004712 glutaminase active site [active] 749219004713 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749219004714 dimer interface [polypeptide binding]; other site 749219004715 active site 749219004716 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 749219004717 dimer interface [polypeptide binding]; other site 749219004718 active site 749219004719 UDP-glucose 4-epimerase; Region: PLN02240 749219004720 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 749219004721 NAD binding site [chemical binding]; other site 749219004722 homodimer interface [polypeptide binding]; other site 749219004723 active site 749219004724 substrate binding site [chemical binding]; other site 749219004725 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 749219004726 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 749219004727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004728 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 749219004729 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 749219004730 active site 749219004731 dimer interface [polypeptide binding]; other site 749219004732 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 749219004733 dimer interface [polypeptide binding]; other site 749219004734 active site 749219004735 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 749219004736 active site 749219004737 tetramer interface; other site 749219004738 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 749219004739 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 749219004740 putative acyl-acceptor binding pocket; other site 749219004741 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 749219004742 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 749219004743 active site 749219004744 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 749219004745 catalytic triad [active] 749219004746 dimer interface [polypeptide binding]; other site 749219004747 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 749219004748 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 749219004749 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 749219004750 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 749219004751 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 749219004752 multifunctional aminopeptidase A; Provisional; Region: PRK00913 749219004753 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 749219004754 interface (dimer of trimers) [polypeptide binding]; other site 749219004755 Substrate-binding/catalytic site; other site 749219004756 Zn-binding sites [ion binding]; other site 749219004757 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 749219004758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749219004759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004760 homodimer interface [polypeptide binding]; other site 749219004761 catalytic residue [active] 749219004762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749219004763 Helix-turn-helix domains; Region: HTH; cl00088 749219004764 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 749219004765 putative dimerization interface [polypeptide binding]; other site 749219004766 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 749219004767 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 749219004768 Domain of unknown function DUF21; Region: DUF21; pfam01595 749219004769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749219004770 Transporter associated domain; Region: CorC_HlyC; cl08393 749219004771 short chain dehydrogenase; Provisional; Region: PRK08703 749219004772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749219004773 NAD(P) binding site [chemical binding]; other site 749219004774 active site 749219004775 phosphoglycolate phosphatase; Provisional; Region: PRK13222 749219004776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749219004777 motif II; other site 749219004778 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 749219004779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004780 S-adenosylmethionine binding site [chemical binding]; other site 749219004781 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 749219004782 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 749219004783 catalytic residues [active] 749219004784 hinge region; other site 749219004785 alpha helical domain; other site 749219004786 Protein of unknown function (DUF615); Region: DUF615; cl01147 749219004787 Microtubule Interacting and Trafficking molecule domain; Region: MIT; smart00745 749219004788 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 749219004789 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 749219004790 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 749219004791 pantoate--beta-alanine ligase; Region: panC; TIGR00018 749219004792 Pantoate-beta-alanine ligase; Region: PanC; cd00560 749219004793 active site 749219004794 ATP-binding site [chemical binding]; other site 749219004795 pantoate-binding site; other site 749219004796 HXXH motif; other site 749219004797 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 749219004798 oligomerization interface [polypeptide binding]; other site 749219004799 active site 749219004800 metal binding site [ion binding]; metal-binding site 749219004801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 749219004802 catalytic center binding site [active] 749219004803 ATP binding site [chemical binding]; other site 749219004804 poly(A) polymerase; Region: pcnB; TIGR01942 749219004805 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 749219004806 active site 749219004807 NTP binding site [chemical binding]; other site 749219004808 metal binding triad [ion binding]; metal-binding site 749219004809 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 749219004810 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 749219004811 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 749219004812 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 749219004813 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 749219004814 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 749219004815 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 749219004816 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749219004817 dimer interface [polypeptide binding]; other site 749219004818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004819 catalytic residue [active] 749219004820 phosphomannomutase CpsG; Provisional; Region: PRK15414 749219004821 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 749219004822 active site 749219004823 substrate binding site [chemical binding]; other site 749219004824 metal binding site [ion binding]; metal-binding site 749219004825 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 749219004826 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 749219004827 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 749219004828 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 749219004829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749219004830 putative substrate translocation pore; other site 749219004831 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749219004832 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749219004833 dimer interface [polypeptide binding]; other site 749219004834 active site 749219004835 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749219004836 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 749219004837 DNA binding site [nucleotide binding] 749219004838 Int/Topo IB signature motif; other site 749219004839 active site 749219004840 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 749219004841 CPxP motif; other site 749219004842 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 749219004843 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 749219004844 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 749219004845 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 749219004846 Walker A/P-loop; other site 749219004847 ATP binding site [chemical binding]; other site 749219004848 Q-loop/lid; other site 749219004849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 749219004850 ABC transporter signature motif; other site 749219004851 Walker B; other site 749219004852 D-loop; other site 749219004853 H-loop/switch region; other site 749219004854 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 749219004855 active site 749219004856 catalytic residues [active] 749219004857 metal binding site [ion binding]; metal-binding site 749219004858 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 749219004859 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 749219004860 putative active site pocket [active] 749219004861 4-fold oligomerization interface [polypeptide binding]; other site 749219004862 metal binding residues [ion binding]; metal-binding site 749219004863 3-fold/trimer interface [polypeptide binding]; other site 749219004864 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 749219004865 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 749219004866 putative active site [active] 749219004867 oxyanion strand; other site 749219004868 catalytic triad [active] 749219004869 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 749219004870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749219004871 ATP binding site [chemical binding]; other site 749219004872 Mg2+ binding site [ion binding]; other site 749219004873 G-X-G motif; other site 749219004874 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 749219004875 anchoring element; other site 749219004876 dimer interface [polypeptide binding]; other site 749219004877 ATP binding site [chemical binding]; other site 749219004878 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 749219004879 active site 749219004880 metal binding site [ion binding]; metal-binding site 749219004881 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749219004882 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 749219004883 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 749219004884 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 749219004885 metal binding site [ion binding]; metal-binding site 749219004886 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 749219004887 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 749219004888 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219004889 ABC-ATPase subunit interface; other site 749219004890 dimer interface [polypeptide binding]; other site 749219004891 putative PBP binding regions; other site 749219004892 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749219004893 ABC-ATPase subunit interface; other site 749219004894 dimer interface [polypeptide binding]; other site 749219004895 putative PBP binding regions; other site 749219004896 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 749219004897 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 749219004898 active site 749219004899 HIGH motif; other site 749219004900 dimer interface [polypeptide binding]; other site 749219004901 KMSKS motif; other site 749219004902 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749219004903 RNA binding surface [nucleotide binding]; other site 749219004904 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 749219004905 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 749219004906 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 749219004907 cofactor binding site; other site 749219004908 DNA binding site [nucleotide binding] 749219004909 substrate interaction site [chemical binding]; other site 749219004910 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749219004911 Cation efflux family; Region: Cation_efflux; cl00316 749219004912 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 749219004913 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 749219004914 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 749219004915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749219004916 inhibitor-cofactor binding pocket; inhibition site 749219004917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004918 catalytic residue [active] 749219004919 Arginase family; Region: Arginase; cl00306 749219004920 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 749219004921 Domain of unknown function (DUF389); Region: DUF389; cl00781 749219004922 Domain of unknown function (DUF389); Region: DUF389; cl00781 749219004923 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 749219004924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004925 S-adenosylmethionine binding site [chemical binding]; other site 749219004926 recombination factor protein RarA; Reviewed; Region: PRK13342 749219004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749219004928 Walker A motif; other site 749219004929 ATP binding site [chemical binding]; other site 749219004930 Walker B motif; other site 749219004931 arginine finger; other site 749219004932 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 749219004933 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 749219004934 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 749219004935 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 749219004936 dimerization interface [polypeptide binding]; other site 749219004937 active site 749219004938 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 749219004939 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 749219004940 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 749219004941 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 749219004942 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 749219004943 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 749219004944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749219004945 catalytic residue [active] 749219004946 16S rRNA methyltransferase B; Provisional; Region: PRK10901 749219004947 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 749219004948 putative RNA binding site [nucleotide binding]; other site 749219004949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749219004950 S-adenosylmethionine binding site [chemical binding]; other site 749219004951 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 749219004952 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 749219004953 putative active site [active] 749219004954 substrate binding site [chemical binding]; other site 749219004955 putative cosubstrate binding site; other site 749219004956 catalytic site [active] 749219004957 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 749219004958 substrate binding site [chemical binding]; other site 749219004959 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 749219004960 Lumazine binding domain; Region: Lum_binding; pfam00677 749219004961 Lumazine binding domain; Region: Lum_binding; pfam00677 749219004962 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 749219004963 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 749219004964 catalytic motif [active] 749219004965 Zn binding site [ion binding]; other site 749219004966 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 749219004967 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 749219004968 ATP cone domain; Region: ATP-cone; pfam03477 749219004969 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 749219004970 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 749219004971 trmE is a tRNA modification GTPase; Region: trmE; cd04164 749219004972 G1 box; other site 749219004973 GTP/Mg2+ binding site [chemical binding]; other site 749219004974 Switch I region; other site 749219004975 G2 box; other site 749219004976 Switch II region; other site 749219004977 G3 box; other site 749219004978 G4 box; other site 749219004979 G5 box; other site 749219004980 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 749219004981 membrane protein insertase; Provisional; Region: PRK01318 749219004982 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 749219004983 Haemolytic domain; Region: Haemolytic; cl00506