-- dump date 20140619_152608 -- class Genbank::misc_feature -- table misc_feature_note -- id note 875328000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 875328000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000003 Walker A motif; other site 875328000004 ATP binding site [chemical binding]; other site 875328000005 Walker B motif; other site 875328000006 arginine finger; other site 875328000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 875328000008 DnaA box-binding interface [nucleotide binding]; other site 875328000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 875328000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 875328000011 putative DNA binding surface [nucleotide binding]; other site 875328000012 dimer interface [polypeptide binding]; other site 875328000013 beta-clamp/clamp loader binding surface; other site 875328000014 beta-clamp/translesion DNA polymerase binding surface; other site 875328000015 recF protein; Region: recf; TIGR00611 875328000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 875328000017 Walker A/P-loop; other site 875328000018 ATP binding site [chemical binding]; other site 875328000019 Q-loop/lid; other site 875328000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328000021 ABC transporter signature motif; other site 875328000022 Walker B; other site 875328000023 D-loop; other site 875328000024 H-loop/switch region; other site 875328000025 hypothetical protein; Provisional; Region: PRK03195 875328000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 875328000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328000028 Mg2+ binding site [ion binding]; other site 875328000029 G-X-G motif; other site 875328000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 875328000031 anchoring element; other site 875328000032 dimer interface [polypeptide binding]; other site 875328000033 ATP binding site [chemical binding]; other site 875328000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 875328000035 active site 875328000036 putative metal-binding site [ion binding]; other site 875328000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 875328000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 875328000039 CAP-like domain; other site 875328000040 active site 875328000041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 875328000042 protein-splicing catalytic site; other site 875328000043 thioester formation/cholesterol transfer; other site 875328000044 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 875328000045 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 875328000046 DNA gyrase subunit A; Validated; Region: PRK05560 875328000047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 875328000048 primary dimer interface [polypeptide binding]; other site 875328000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 875328000056 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 875328000057 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 875328000058 active site 875328000059 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 875328000060 putative septation inhibitor protein; Reviewed; Region: PRK00159 875328000061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 875328000062 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 875328000063 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 875328000064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 875328000065 glutamine binding [chemical binding]; other site 875328000066 catalytic triad [active] 875328000067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328000068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328000069 active site 875328000070 ATP binding site [chemical binding]; other site 875328000071 substrate binding site [chemical binding]; other site 875328000072 activation loop (A-loop); other site 875328000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 875328000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 875328000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 875328000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 875328000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 875328000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328000080 active site 875328000081 ATP binding site [chemical binding]; other site 875328000082 substrate binding site [chemical binding]; other site 875328000083 activation loop (A-loop); other site 875328000084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 875328000085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 875328000086 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 875328000087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 875328000088 active site 875328000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 875328000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 875328000091 phosphopeptide binding site; other site 875328000092 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 875328000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 875328000094 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 875328000095 phosphopeptide binding site; other site 875328000096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328000097 Coenzyme A binding pocket [chemical binding]; other site 875328000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 875328000099 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 875328000100 CAP-like domain; other site 875328000101 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 875328000102 active site 875328000103 primary dimer interface [polypeptide binding]; other site 875328000104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 875328000105 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 875328000106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328000107 Mg2+ binding site [ion binding]; other site 875328000108 G-X-G motif; other site 875328000109 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 875328000110 ATP binding site [chemical binding]; other site 875328000111 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 875328000112 active site 875328000113 metal binding site [ion binding]; metal-binding site 875328000114 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 875328000115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000117 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 875328000118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328000119 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 875328000120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328000121 acyl-CoA synthetase; Provisional; Region: PRK13388 875328000122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000123 acyl-activating enzyme (AAE) consensus motif; other site 875328000124 AMP binding site [chemical binding]; other site 875328000125 active site 875328000126 CoA binding site [chemical binding]; other site 875328000127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328000128 classical (c) SDRs; Region: SDR_c; cd05233 875328000129 NAD(P) binding site [chemical binding]; other site 875328000130 active site 875328000131 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328000132 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 875328000133 NAD(P) binding site [chemical binding]; other site 875328000134 Pirin-related protein [General function prediction only]; Region: COG1741 875328000135 Pirin; Region: Pirin; pfam02678 875328000136 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 875328000137 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 875328000138 NlpC/P60 family; Region: NLPC_P60; pfam00877 875328000139 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 875328000140 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 875328000141 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 875328000142 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 875328000143 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 875328000144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000145 Walker A motif; other site 875328000146 ATP binding site [chemical binding]; other site 875328000147 Walker B motif; other site 875328000148 arginine finger; other site 875328000149 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 875328000150 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 875328000151 catalytic residues [active] 875328000152 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 875328000153 active site 875328000154 catalytic residues [active] 875328000155 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 875328000156 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 875328000157 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 875328000158 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328000159 EspG family; Region: ESX-1_EspG; pfam14011 875328000160 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328000161 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328000162 PPE family; Region: PPE; pfam00823 875328000163 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 875328000164 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000165 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 875328000166 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000167 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000168 Protein of unknown function (DUF690); Region: DUF690; pfam05108 875328000169 wnt family; Region: wnt; pfam00110 875328000170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328000171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328000172 active site 875328000173 ATP binding site [chemical binding]; other site 875328000174 substrate binding site [chemical binding]; other site 875328000175 activation loop (A-loop); other site 875328000176 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328000177 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 875328000178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328000179 active site 875328000180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 875328000181 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 875328000182 Nitronate monooxygenase; Region: NMO; pfam03060 875328000183 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328000184 FMN binding site [chemical binding]; other site 875328000185 substrate binding site [chemical binding]; other site 875328000186 putative catalytic residue [active] 875328000187 Sulfatase; Region: Sulfatase; cl17466 875328000188 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 875328000189 Uncharacterized conserved protein [Function unknown]; Region: COG3379 875328000190 Uncharacterized conserved protein [Function unknown]; Region: COG3379 875328000191 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 875328000192 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 875328000193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000194 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 875328000195 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328000196 FAD binding pocket [chemical binding]; other site 875328000197 FAD binding motif [chemical binding]; other site 875328000198 phosphate binding motif [ion binding]; other site 875328000199 beta-alpha-beta structure motif; other site 875328000200 NAD binding pocket [chemical binding]; other site 875328000201 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 875328000202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328000203 catalytic loop [active] 875328000204 iron binding site [ion binding]; other site 875328000205 Fatty acid desaturase; Region: FA_desaturase; pfam00487 875328000206 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 875328000207 putative di-iron ligands [ion binding]; other site 875328000208 TOBE domain; Region: TOBE; cl01440 875328000209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000211 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328000212 Cytochrome P450; Region: p450; cl12078 875328000213 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328000214 CoenzymeA binding site [chemical binding]; other site 875328000215 subunit interaction site [polypeptide binding]; other site 875328000216 PHB binding site; other site 875328000217 methionine sulfoxide reductase A; Provisional; Region: PRK14054 875328000218 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328000219 Cytochrome P450; Region: p450; cl12078 875328000220 Esterase/lipase [General function prediction only]; Region: COG1647 875328000221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000223 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328000224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328000225 substrate binding site [chemical binding]; other site 875328000226 oxyanion hole (OAH) forming residues; other site 875328000227 trimer interface [polypeptide binding]; other site 875328000228 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 875328000229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328000230 Zn binding site [ion binding]; other site 875328000231 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328000232 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 875328000233 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 875328000234 putative NADP binding site [chemical binding]; other site 875328000235 putative substrate binding site [chemical binding]; other site 875328000236 active site 875328000237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 875328000238 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 875328000239 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 875328000240 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 875328000241 minor groove reading motif; other site 875328000242 helix-hairpin-helix signature motif; other site 875328000243 substrate binding pocket [chemical binding]; other site 875328000244 active site 875328000245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000249 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328000250 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328000251 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 875328000252 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 875328000253 NAD(P) binding site [chemical binding]; other site 875328000254 catalytic residues [active] 875328000255 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328000256 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 875328000257 homodimer interface [polypeptide binding]; other site 875328000258 NAD binding site [chemical binding]; other site 875328000259 active site 875328000260 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 875328000261 Methyl-coenzyme M reductase alpha subunit, C-terminal domain; Region: MCR_alpha; pfam02249 875328000262 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 875328000263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000265 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328000266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328000267 active site 875328000268 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328000269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328000270 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 875328000271 FAD binding domain; Region: FAD_binding_4; pfam01565 875328000272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328000275 NAD(P) binding site [chemical binding]; other site 875328000276 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 875328000277 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 875328000278 Strictosidine synthase; Region: Str_synth; pfam03088 875328000279 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 875328000280 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 875328000281 active site 875328000282 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 875328000283 catalytic triad [active] 875328000284 dimer interface [polypeptide binding]; other site 875328000285 Domain of unknown function (DUF427); Region: DUF427; pfam04248 875328000286 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328000287 Cytochrome P450; Region: p450; cl12078 875328000288 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328000289 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 875328000290 NAD(P) binding site [chemical binding]; other site 875328000291 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 875328000292 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 875328000293 classical (c) SDRs; Region: SDR_c; cd05233 875328000294 NAD(P) binding site [chemical binding]; other site 875328000295 active site 875328000296 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328000297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328000298 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 875328000299 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328000300 NAD(P) binding site [chemical binding]; other site 875328000301 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 875328000302 active site 875328000303 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 875328000304 putative hydrophobic ligand binding site [chemical binding]; other site 875328000305 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 875328000306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000307 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328000308 acyl-activating enzyme (AAE) consensus motif; other site 875328000309 acyl-activating enzyme (AAE) consensus motif; other site 875328000310 putative AMP binding site [chemical binding]; other site 875328000311 putative active site [active] 875328000312 putative CoA binding site [chemical binding]; other site 875328000313 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328000314 Permease; Region: Permease; pfam02405 875328000315 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328000316 Permease; Region: Permease; pfam02405 875328000317 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000318 mce related protein; Region: MCE; pfam02470 875328000319 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328000320 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000321 mce related protein; Region: MCE; pfam02470 875328000322 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000323 mce related protein; Region: MCE; pfam02470 875328000324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 875328000325 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000326 mce related protein; Region: MCE; pfam02470 875328000327 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000328 mce related protein; Region: MCE; pfam02470 875328000329 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000330 mce related protein; Region: MCE; pfam02470 875328000331 RDD family; Region: RDD; pfam06271 875328000332 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 875328000333 Mannan-binding protein; Region: MVL; pfam12151 875328000334 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 875328000335 mce related protein; Region: MCE; pfam02470 875328000336 mce related protein; Region: MCE; pfam02470 875328000337 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328000338 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000339 mce related protein; Region: MCE; pfam02470 875328000340 mce related protein; Region: MCE; pfam02470 875328000341 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328000342 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 875328000343 mce related protein; Region: MCE; pfam02470 875328000344 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 875328000345 mce related protein; Region: MCE; pfam02470 875328000346 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328000347 Permease; Region: Permease; pfam02405 875328000348 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328000349 Permease; Region: Permease; pfam02405 875328000350 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 875328000351 Pirin; Region: Pirin; pfam02678 875328000352 Pirin-related protein [General function prediction only]; Region: COG1741 875328000353 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 875328000354 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 875328000355 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 875328000356 NAD binding site [chemical binding]; other site 875328000357 catalytic Zn binding site [ion binding]; other site 875328000358 substrate binding site [chemical binding]; other site 875328000359 structural Zn binding site [ion binding]; other site 875328000360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328000361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328000362 NAD(P) binding site [chemical binding]; other site 875328000363 active site 875328000364 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 875328000365 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328000366 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 875328000367 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 875328000368 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 875328000369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328000370 S-adenosylmethionine binding site [chemical binding]; other site 875328000371 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 875328000372 apolar tunnel; other site 875328000373 heme binding site [chemical binding]; other site 875328000374 dimerization interface [polypeptide binding]; other site 875328000375 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 875328000376 6-phosphogluconate dehydratase; Region: edd; TIGR01196 875328000377 Domain of unknown function (DUF305); Region: DUF305; pfam03713 875328000378 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 875328000379 putative homodimer interface [polypeptide binding]; other site 875328000380 putative homotetramer interface [polypeptide binding]; other site 875328000381 putative allosteric switch controlling residues; other site 875328000382 putative metal binding site [ion binding]; other site 875328000383 putative homodimer-homodimer interface [polypeptide binding]; other site 875328000384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 875328000385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328000386 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 875328000387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 875328000388 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 875328000389 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 875328000390 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 875328000391 active site 875328000392 Zn binding site [ion binding]; other site 875328000393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 875328000394 non-specific DNA binding site [nucleotide binding]; other site 875328000395 salt bridge; other site 875328000396 sequence-specific DNA binding site [nucleotide binding]; other site 875328000397 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328000398 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 875328000399 Predicted integral membrane protein [Function unknown]; Region: COG0392 875328000400 Domain of unknown function DUF20; Region: UPF0118; pfam01594 875328000401 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 875328000402 MMPL family; Region: MMPL; pfam03176 875328000403 MMPL family; Region: MMPL; pfam03176 875328000404 LabA_like proteins; Region: LabA_like; cd06167 875328000405 putative metal binding site [ion binding]; other site 875328000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328000407 S-adenosylmethionine binding site [chemical binding]; other site 875328000408 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 875328000409 active site 875328000410 substrate-binding site [chemical binding]; other site 875328000411 metal-binding site [ion binding] 875328000412 GTP binding site [chemical binding]; other site 875328000413 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 875328000414 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 875328000415 WHG domain; Region: WHG; pfam13305 875328000416 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 875328000417 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000418 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328000419 acyl-activating enzyme (AAE) consensus motif; other site 875328000420 acyl-activating enzyme (AAE) consensus motif; other site 875328000421 putative AMP binding site [chemical binding]; other site 875328000422 putative active site [active] 875328000423 putative CoA binding site [chemical binding]; other site 875328000424 CoA binding site [chemical binding]; other site 875328000425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328000426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000427 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000428 active site 875328000429 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 875328000430 putative active site [active] 875328000431 putative catalytic site [active] 875328000432 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328000433 active site 2 [active] 875328000434 active site 1 [active] 875328000435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000437 active site 875328000438 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000439 active site 875328000440 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328000441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328000442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328000443 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328000444 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328000445 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328000446 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328000447 acyl-CoA synthetase; Provisional; Region: PRK13382 875328000448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000449 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000450 acyl-activating enzyme (AAE) consensus motif; other site 875328000451 AMP binding site [chemical binding]; other site 875328000452 active site 875328000453 CoA binding site [chemical binding]; other site 875328000454 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328000455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 875328000456 putative acyl-acceptor binding pocket; other site 875328000457 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 875328000458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000459 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 875328000460 FAD binding site [chemical binding]; other site 875328000461 substrate binding site [chemical binding]; other site 875328000462 catalytic residues [active] 875328000463 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 875328000464 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 875328000465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328000466 NAD binding site [chemical binding]; other site 875328000467 catalytic residues [active] 875328000468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328000469 S-adenosylmethionine binding site [chemical binding]; other site 875328000470 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328000471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328000472 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 875328000473 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328000474 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328000475 active site 875328000476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000477 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 875328000478 Subunit I/III interface [polypeptide binding]; other site 875328000479 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 875328000480 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 875328000481 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328000482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000484 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328000485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000487 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 875328000488 active site 875328000489 substrate binding pocket [chemical binding]; other site 875328000490 homodimer interaction site [polypeptide binding]; other site 875328000491 MarR family; Region: MarR_2; pfam12802 875328000492 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328000493 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 875328000494 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328000495 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328000496 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 875328000497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 875328000498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000500 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 875328000501 active site 875328000502 diiron metal binding site [ion binding]; other site 875328000503 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 875328000504 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 875328000505 NAD(P) binding site [chemical binding]; other site 875328000506 catalytic residues [active] 875328000507 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 875328000508 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 875328000509 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 875328000510 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 875328000511 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 875328000512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000514 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328000515 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328000516 active site 2 [active] 875328000517 active site 1 [active] 875328000518 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 875328000519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328000520 NAD(P) binding site [chemical binding]; other site 875328000521 active site 875328000522 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 875328000523 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328000524 dimer interface [polypeptide binding]; other site 875328000525 active site 875328000526 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 875328000527 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 875328000528 conserved cys residue [active] 875328000529 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 875328000530 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 875328000531 conserved cys residue [active] 875328000532 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 875328000533 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 875328000534 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 875328000535 FAD binding site [chemical binding]; other site 875328000536 substrate binding site [chemical binding]; other site 875328000537 catalytic residues [active] 875328000538 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 875328000539 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 875328000540 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 875328000541 active site 875328000542 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 875328000543 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 875328000544 active site 875328000545 catalytic tetrad [active] 875328000546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 875328000547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 875328000548 active site 875328000549 catalytic tetrad [active] 875328000550 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 875328000551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328000552 catalytic loop [active] 875328000553 iron binding site [ion binding]; other site 875328000554 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 875328000555 L-aspartate oxidase; Provisional; Region: PRK06175 875328000556 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 875328000557 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 875328000558 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 875328000559 putative dimer interface [polypeptide binding]; other site 875328000560 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 875328000561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328000562 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 875328000563 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 875328000564 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 875328000565 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 875328000566 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 875328000567 active site 875328000568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328000569 DNA binding site [nucleotide binding] 875328000570 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 875328000571 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 875328000572 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 875328000573 putative active site [active] 875328000574 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 875328000575 putative active site [active] 875328000576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 875328000577 DNA binding site [nucleotide binding] 875328000578 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 875328000579 Predicted permease [General function prediction only]; Region: COG3329 875328000580 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 875328000581 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 875328000582 Sulfate transporter family; Region: Sulfate_transp; pfam00916 875328000583 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 875328000584 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 875328000585 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 875328000586 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 875328000587 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 875328000588 intersubunit interface [polypeptide binding]; other site 875328000589 5-oxoprolinase; Region: PLN02666 875328000590 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 875328000591 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 875328000592 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 875328000593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328000594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328000595 sequence-specific DNA binding site [nucleotide binding]; other site 875328000596 salt bridge; other site 875328000597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000599 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000600 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000601 active site 875328000602 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328000603 Phosphotransferase enzyme family; Region: APH; pfam01636 875328000604 putative active site [active] 875328000605 putative substrate binding site [chemical binding]; other site 875328000606 ATP binding site [chemical binding]; other site 875328000607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 875328000608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328000609 NAD(P) binding site [chemical binding]; other site 875328000610 active site 875328000611 acyl-CoA synthetase; Provisional; Region: PRK13388 875328000612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000613 acyl-activating enzyme (AAE) consensus motif; other site 875328000614 AMP binding site [chemical binding]; other site 875328000615 active site 875328000616 CoA binding site [chemical binding]; other site 875328000617 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 875328000618 nucleotide binding site [chemical binding]; other site 875328000619 acyl-CoA synthetase; Validated; Region: PRK07788 875328000620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328000622 active site 875328000623 CoA binding site [chemical binding]; other site 875328000624 AMP binding site [chemical binding]; other site 875328000625 TQO small subunit DoxD; Region: DoxD; pfam04173 875328000626 TQO small subunit DoxA; Region: DoxA; pfam07680 875328000627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000629 active site 875328000630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328000631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328000632 active site 875328000633 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 875328000634 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 875328000635 putative ligand binding site [chemical binding]; other site 875328000636 putative NAD binding site [chemical binding]; other site 875328000637 catalytic site [active] 875328000638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000640 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 875328000641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328000642 Zn binding site [ion binding]; other site 875328000643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000644 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 875328000645 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 875328000646 G1 box; other site 875328000647 putative GEF interaction site [polypeptide binding]; other site 875328000648 GTP/Mg2+ binding site [chemical binding]; other site 875328000649 Switch I region; other site 875328000650 G2 box; other site 875328000651 G3 box; other site 875328000652 Switch II region; other site 875328000653 G4 box; other site 875328000654 G5 box; other site 875328000655 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 875328000656 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 875328000657 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 875328000658 selenocysteine synthase; Provisional; Region: PRK04311 875328000659 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 875328000660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328000661 selenium donor protein; Region: selD; TIGR00476 875328000662 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 875328000663 dimerization interface [polypeptide binding]; other site 875328000664 putative ATP binding site [chemical binding]; other site 875328000665 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 875328000666 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 875328000667 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 875328000668 putative active site [active] 875328000669 urease subunit alpha; Reviewed; Region: ureC; PRK13207 875328000670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328000671 active site 875328000672 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 875328000673 gamma-beta subunit interface [polypeptide binding]; other site 875328000674 alpha-beta subunit interface [polypeptide binding]; other site 875328000675 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 875328000676 alpha-gamma subunit interface [polypeptide binding]; other site 875328000677 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 875328000678 4Fe-4S binding domain; Region: Fer4; pfam00037 875328000679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328000680 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328000681 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328000682 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 875328000683 molybdopterin cofactor binding site; other site 875328000684 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328000685 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 875328000686 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328000687 PPE family; Region: PPE; pfam00823 875328000688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 875328000689 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328000690 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328000691 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 875328000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000693 Walker A motif; other site 875328000694 ATP binding site [chemical binding]; other site 875328000695 Walker B motif; other site 875328000696 arginine finger; other site 875328000697 Protein of unknown function (DUF690); Region: DUF690; cl04939 875328000698 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 875328000699 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000700 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 875328000701 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000702 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328000703 PE family; Region: PE; pfam00934 875328000704 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328000705 PPE family; Region: PPE; pfam00823 875328000706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 875328000707 EspG family; Region: ESX-1_EspG; pfam14011 875328000708 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 875328000709 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 875328000710 active site 875328000711 catalytic residues [active] 875328000712 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 875328000713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328000714 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328000715 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 875328000716 active site 875328000717 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 875328000718 putative FMN binding site [chemical binding]; other site 875328000719 NMDA receptor-regulated protein 1; Region: NARP1; pfam12569 875328000720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 875328000721 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328000722 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328000723 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328000724 PPE family; Region: PPE; pfam00823 875328000725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328000726 PPE family; Region: PPE; pfam00823 875328000727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000731 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328000732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328000733 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 875328000734 active site 875328000735 catalytic residues [active] 875328000736 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 875328000737 active site 875328000738 catalytic residues [active] 875328000739 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 875328000740 trimer interface [polypeptide binding]; other site 875328000741 active site 875328000742 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 875328000743 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 875328000744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328000745 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 875328000746 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 875328000747 substrate binding site; other site 875328000748 tetramer interface; other site 875328000749 aminotransferase AlaT; Validated; Region: PRK09265 875328000750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328000751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328000752 homodimer interface [polypeptide binding]; other site 875328000753 catalytic residue [active] 875328000754 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 875328000755 4Fe-4S binding domain; Region: Fer4; pfam00037 875328000756 Cysteine-rich domain; Region: CCG; pfam02754 875328000757 Cysteine-rich domain; Region: CCG; pfam02754 875328000758 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 875328000759 amino acid transporter; Region: 2A0306; TIGR00909 875328000760 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328000761 Cytochrome P450; Region: p450; cl12078 875328000762 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 875328000763 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 875328000764 nucleotide binding site [chemical binding]; other site 875328000765 NEF interaction site [polypeptide binding]; other site 875328000766 SBD interface [polypeptide binding]; other site 875328000767 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 875328000768 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 875328000769 dimer interface [polypeptide binding]; other site 875328000770 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 875328000771 chaperone protein DnaJ; Provisional; Region: PRK14279 875328000772 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 875328000773 HSP70 interaction site [polypeptide binding]; other site 875328000774 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 875328000775 Zn binding sites [ion binding]; other site 875328000776 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 875328000777 dimer interface [polypeptide binding]; other site 875328000778 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 875328000779 DNA binding residues [nucleotide binding] 875328000780 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 875328000781 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 875328000782 active site 875328000783 catalytic residues [active] 875328000784 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 875328000785 heme-binding site [chemical binding]; other site 875328000786 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 875328000787 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 875328000788 FAD binding pocket [chemical binding]; other site 875328000789 FAD binding motif [chemical binding]; other site 875328000790 phosphate binding motif [ion binding]; other site 875328000791 beta-alpha-beta structure motif; other site 875328000792 NAD binding pocket [chemical binding]; other site 875328000793 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 875328000794 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 875328000795 Clp amino terminal domain; Region: Clp_N; pfam02861 875328000796 Clp amino terminal domain; Region: Clp_N; pfam02861 875328000797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000798 Walker A motif; other site 875328000799 ATP binding site [chemical binding]; other site 875328000800 Walker B motif; other site 875328000801 arginine finger; other site 875328000802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000803 Walker A motif; other site 875328000804 ATP binding site [chemical binding]; other site 875328000805 Walker B motif; other site 875328000806 arginine finger; other site 875328000807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 875328000808 classical (c) SDRs; Region: SDR_c; cd05233 875328000809 NAD(P) binding site [chemical binding]; other site 875328000810 active site 875328000811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328000812 active site 875328000813 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 875328000814 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 875328000815 H+ Antiporter protein; Region: 2A0121; TIGR00900 875328000816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328000817 putative substrate translocation pore; other site 875328000818 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 875328000819 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 875328000820 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 875328000821 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 875328000822 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 875328000823 active site 875328000824 intersubunit interface [polypeptide binding]; other site 875328000825 zinc binding site [ion binding]; other site 875328000826 Na+ binding site [ion binding]; other site 875328000827 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 875328000828 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 875328000829 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 875328000830 active site 875328000831 putative substrate binding region [chemical binding]; other site 875328000832 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 875328000833 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 875328000834 GDP-binding site [chemical binding]; other site 875328000835 ACT binding site; other site 875328000836 IMP binding site; other site 875328000837 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328000838 CoenzymeA binding site [chemical binding]; other site 875328000839 subunit interaction site [polypeptide binding]; other site 875328000840 PHB binding site; other site 875328000841 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 875328000842 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 875328000843 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328000844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 875328000845 active site residue [active] 875328000846 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 875328000847 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 875328000848 homodimer interface [polypeptide binding]; other site 875328000849 substrate-cofactor binding pocket; other site 875328000850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328000851 catalytic residue [active] 875328000852 short chain dehydrogenase; Provisional; Region: PRK07825 875328000853 classical (c) SDRs; Region: SDR_c; cd05233 875328000854 NAD(P) binding site [chemical binding]; other site 875328000855 active site 875328000856 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 875328000857 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 875328000858 tetramer interface [polypeptide binding]; other site 875328000859 active site 875328000860 Mg2+/Mn2+ binding site [ion binding]; other site 875328000861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 875328000862 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328000863 acyl-activating enzyme (AAE) consensus motif; other site 875328000864 putative AMP binding site [chemical binding]; other site 875328000865 putative active site [active] 875328000866 putative CoA binding site [chemical binding]; other site 875328000867 Uncharacterized conserved protein [Function unknown]; Region: COG3379 875328000868 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 875328000869 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 875328000870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 875328000871 TrkA-C domain; Region: TrkA_C; pfam02080 875328000872 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 875328000873 TrkA-N domain; Region: TrkA_N; pfam02254 875328000874 TrkA-C domain; Region: TrkA_C; pfam02080 875328000875 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328000876 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328000877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328000878 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 875328000879 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328000880 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328000881 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328000882 active site 875328000883 ATP binding site [chemical binding]; other site 875328000884 substrate binding site [chemical binding]; other site 875328000885 activation loop (A-loop); other site 875328000886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 875328000887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 875328000888 substrate binding pocket [chemical binding]; other site 875328000889 membrane-bound complex binding site; other site 875328000890 hinge residues; other site 875328000891 NUDIX domain; Region: NUDIX; pfam00293 875328000892 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 875328000893 thiamine phosphate binding site [chemical binding]; other site 875328000894 active site 875328000895 pyrophosphate binding site [ion binding]; other site 875328000896 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 875328000897 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 875328000898 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 875328000899 thiS-thiF/thiG interaction site; other site 875328000900 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 875328000901 ThiS interaction site; other site 875328000902 putative active site [active] 875328000903 tetramer interface [polypeptide binding]; other site 875328000904 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 875328000905 active site 875328000906 oxyanion hole [active] 875328000907 catalytic triad [active] 875328000908 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 875328000909 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 875328000910 PA/protease or protease-like domain interface [polypeptide binding]; other site 875328000911 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 875328000912 Peptidase family M28; Region: Peptidase_M28; pfam04389 875328000913 active site 875328000914 metal binding site [ion binding]; metal-binding site 875328000915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000918 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328000919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328000920 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 875328000921 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 875328000922 dimer interface [polypeptide binding]; other site 875328000923 substrate binding site [chemical binding]; other site 875328000924 ATP binding site [chemical binding]; other site 875328000925 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 875328000926 ThiC-associated domain; Region: ThiC-associated; pfam13667 875328000927 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 875328000928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328000929 putative substrate translocation pore; other site 875328000930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328000931 putative substrate translocation pore; other site 875328000932 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328000933 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 875328000934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328000935 motif II; other site 875328000936 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 875328000937 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 875328000938 putative catalytic site [active] 875328000939 putative phosphate binding site [ion binding]; other site 875328000940 active site 875328000941 metal binding site A [ion binding]; metal-binding site 875328000942 DNA binding site [nucleotide binding] 875328000943 putative AP binding site [nucleotide binding]; other site 875328000944 putative metal binding site B [ion binding]; other site 875328000945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328000946 Coenzyme A binding pocket [chemical binding]; other site 875328000947 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 875328000948 active site 875328000949 catalytic residues [active] 875328000950 metal binding site [ion binding]; metal-binding site 875328000951 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 875328000952 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 875328000953 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 875328000954 E-class dimer interface [polypeptide binding]; other site 875328000955 P-class dimer interface [polypeptide binding]; other site 875328000956 active site 875328000957 Cu2+ binding site [ion binding]; other site 875328000958 Zn2+ binding site [ion binding]; other site 875328000959 carboxylate-amine ligase; Provisional; Region: PRK13517 875328000960 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 875328000961 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 875328000962 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328000963 classical (c) SDRs; Region: SDR_c; cd05233 875328000964 NAD(P) binding site [chemical binding]; other site 875328000965 active site 875328000966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000968 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328000969 Cytochrome P450; Region: p450; cl12078 875328000970 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328000971 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328000972 NAD(P) binding site [chemical binding]; other site 875328000973 catalytic residues [active] 875328000974 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328000975 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328000976 NAD(P) binding site [chemical binding]; other site 875328000977 catalytic residues [active] 875328000978 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 875328000979 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 875328000980 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328000981 classical (c) SDRs; Region: SDR_c; cd05233 875328000982 NAD(P) binding site [chemical binding]; other site 875328000983 active site 875328000984 short chain dehydrogenase; Provisional; Region: PRK12827 875328000985 classical (c) SDRs; Region: SDR_c; cd05233 875328000986 NAD(P) binding site [chemical binding]; other site 875328000987 active site 875328000988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328000989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328000990 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 875328000991 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 875328000992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000993 Walker A motif; other site 875328000994 ATP binding site [chemical binding]; other site 875328000995 Walker B motif; other site 875328000996 arginine finger; other site 875328000997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328000998 Walker A motif; other site 875328000999 ATP binding site [chemical binding]; other site 875328001000 Walker B motif; other site 875328001001 arginine finger; other site 875328001002 chorismate mutase; Provisional; Region: PRK09269 875328001003 Chorismate mutase type II; Region: CM_2; cl00693 875328001004 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 875328001005 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 875328001006 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 875328001007 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 875328001008 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 875328001009 dimer interface [polypeptide binding]; other site 875328001010 putative functional site; other site 875328001011 putative MPT binding site; other site 875328001012 Uncharacterized conserved protein [Function unknown]; Region: COG3402 875328001013 Predicted membrane protein [Function unknown]; Region: COG3428 875328001014 Bacterial PH domain; Region: DUF304; pfam03703 875328001015 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 875328001016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001017 ATP binding site [chemical binding]; other site 875328001018 putative Mg++ binding site [ion binding]; other site 875328001019 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 875328001020 active site 875328001021 short chain dehydrogenase; Provisional; Region: PRK06197 875328001022 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 875328001023 putative NAD(P) binding site [chemical binding]; other site 875328001024 active site 875328001025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001027 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 875328001028 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 875328001029 ring oligomerisation interface [polypeptide binding]; other site 875328001030 ATP/Mg binding site [chemical binding]; other site 875328001031 stacking interactions; other site 875328001032 hinge regions; other site 875328001033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 875328001034 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 875328001035 homotrimer interface [polypeptide binding]; other site 875328001036 Walker A motif; other site 875328001037 GTP binding site [chemical binding]; other site 875328001038 Walker B motif; other site 875328001039 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 875328001040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 875328001041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 875328001042 active site 875328001043 catalytic tetrad [active] 875328001044 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 875328001045 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328001046 active site 875328001047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328001048 Protein of unknown function (DUF664); Region: DUF664; pfam04978 875328001049 DinB superfamily; Region: DinB_2; pfam12867 875328001050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328001051 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 875328001052 NAD(P) binding site [chemical binding]; other site 875328001053 catalytic residues [active] 875328001054 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 875328001055 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 875328001056 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 875328001057 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328001058 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328001059 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328001060 NAD(P) binding site [chemical binding]; other site 875328001061 catalytic residues [active] 875328001062 Protein of unknown function (DUF779); Region: DUF779; cl01432 875328001063 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 875328001064 putative active site [active] 875328001065 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 875328001066 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 875328001067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328001068 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 875328001069 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328001070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001071 S-adenosylmethionine binding site [chemical binding]; other site 875328001072 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328001073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001074 S-adenosylmethionine binding site [chemical binding]; other site 875328001075 Integral membrane protein DUF92; Region: DUF92; cl00793 875328001076 Uncharacterized conserved protein [Function unknown]; Region: COG2128 875328001077 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 875328001078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328001079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328001080 non-specific DNA binding site [nucleotide binding]; other site 875328001081 salt bridge; other site 875328001082 sequence-specific DNA binding site [nucleotide binding]; other site 875328001083 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 875328001084 Domain of unknown function (DUF955); Region: DUF955; pfam06114 875328001085 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 875328001086 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 875328001087 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328001088 active site 2 [active] 875328001089 active site 1 [active] 875328001090 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328001091 active site 2 [active] 875328001092 isocitrate lyase; Provisional; Region: PRK15063 875328001093 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 875328001094 tetramer interface [polypeptide binding]; other site 875328001095 active site 875328001096 Mg2+/Mn2+ binding site [ion binding]; other site 875328001097 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 875328001098 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 875328001099 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 875328001100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001102 Predicted membrane protein [Function unknown]; Region: COG2733 875328001103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328001104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328001105 non-specific DNA binding site [nucleotide binding]; other site 875328001106 salt bridge; other site 875328001107 sequence-specific DNA binding site [nucleotide binding]; other site 875328001108 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 875328001109 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 875328001110 Class I aldolases; Region: Aldolase_Class_I; cl17187 875328001111 catalytic residue [active] 875328001112 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 875328001113 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 875328001114 Predicted amidohydrolase [General function prediction only]; Region: COG0388 875328001115 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 875328001116 putative active site [active] 875328001117 catalytic triad [active] 875328001118 putative dimer interface [polypeptide binding]; other site 875328001119 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 875328001120 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 875328001121 FAD binding domain; Region: FAD_binding_4; pfam01565 875328001122 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 875328001123 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 875328001124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 875328001125 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 875328001126 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 875328001127 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 875328001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328001129 NAD(P) binding site [chemical binding]; other site 875328001130 active site 875328001131 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 875328001132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 875328001133 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 875328001134 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 875328001135 putative ADP-binding pocket [chemical binding]; other site 875328001136 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 875328001137 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328001138 catalytic core [active] 875328001139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328001140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328001141 dimer interface [polypeptide binding]; other site 875328001142 phosphorylation site [posttranslational modification] 875328001143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328001144 ATP binding site [chemical binding]; other site 875328001145 Mg2+ binding site [ion binding]; other site 875328001146 G-X-G motif; other site 875328001147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328001148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328001149 active site 875328001150 phosphorylation site [posttranslational modification] 875328001151 intermolecular recognition site; other site 875328001152 dimerization interface [polypeptide binding]; other site 875328001153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328001154 DNA binding site [nucleotide binding] 875328001155 acyl-CoA synthetase; Validated; Region: PRK05850 875328001156 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328001157 acyl-activating enzyme (AAE) consensus motif; other site 875328001158 active site 875328001159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328001160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 875328001161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328001162 active site 875328001163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328001164 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 875328001165 putative NADP binding site [chemical binding]; other site 875328001166 KR domain; Region: KR; pfam08659 875328001167 active site 875328001168 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328001169 Condensation domain; Region: Condensation; pfam00668 875328001170 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 875328001171 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 875328001172 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 875328001173 acyl-activating enzyme (AAE) consensus motif; other site 875328001174 AMP binding site [chemical binding]; other site 875328001175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328001176 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 875328001177 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 875328001178 active site 875328001179 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 875328001180 active site 875328001181 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 875328001182 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 875328001183 putative NADP binding site [chemical binding]; other site 875328001184 putative substrate binding site [chemical binding]; other site 875328001185 active site 875328001186 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328001187 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328001188 active site 875328001189 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 875328001190 amidase; Provisional; Region: PRK12470 875328001191 Amidase; Region: Amidase; cl11426 875328001192 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 875328001193 FAD binding domain; Region: FAD_binding_4; pfam01565 875328001194 Berberine and berberine like; Region: BBE; pfam08031 875328001195 FtsX-like permease family; Region: FtsX; pfam02687 875328001196 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 875328001197 FtsX-like permease family; Region: FtsX; pfam02687 875328001198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 875328001199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 875328001200 Walker A/P-loop; other site 875328001201 ATP binding site [chemical binding]; other site 875328001202 Q-loop/lid; other site 875328001203 ABC transporter signature motif; other site 875328001204 Walker B; other site 875328001205 D-loop; other site 875328001206 H-loop/switch region; other site 875328001207 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 875328001208 exopolyphosphatase; Region: exo_poly_only; TIGR03706 875328001209 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 875328001210 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 875328001211 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328001212 active site 2 [active] 875328001213 active site 1 [active] 875328001214 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 875328001215 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 875328001216 DNA binding domain, excisionase family; Region: excise; TIGR01764 875328001217 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 875328001218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328001219 putative NAD(P) binding site [chemical binding]; other site 875328001220 active site 875328001221 putative substrate binding site [chemical binding]; other site 875328001222 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328001223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 875328001224 putative acyl-acceptor binding pocket; other site 875328001225 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 875328001226 active site 875328001227 catalytic site [active] 875328001228 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 875328001229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328001230 motif II; other site 875328001231 SnoaL-like domain; Region: SnoaL_4; pfam13577 875328001232 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 875328001233 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 875328001234 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 875328001235 tRNA; other site 875328001236 putative tRNA binding site [nucleotide binding]; other site 875328001237 putative NADP binding site [chemical binding]; other site 875328001238 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 875328001239 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 875328001240 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 875328001241 active site 875328001242 domain interfaces; other site 875328001243 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 875328001244 active site 875328001245 homodimer interface [polypeptide binding]; other site 875328001246 SAM binding site [chemical binding]; other site 875328001247 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 875328001248 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 875328001249 active site 875328001250 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 875328001251 dimer interface [polypeptide binding]; other site 875328001252 active site 875328001253 Schiff base residues; other site 875328001254 hypothetical protein; Provisional; Region: PRK07945 875328001255 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 875328001256 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 875328001257 active site 875328001258 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 875328001259 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 875328001260 metal-binding site [ion binding] 875328001261 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328001262 Soluble P-type ATPase [General function prediction only]; Region: COG4087 875328001263 Putative esterase; Region: Esterase; pfam00756 875328001264 S-formylglutathione hydrolase; Region: PLN02442 875328001265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 875328001266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 875328001267 Walker A/P-loop; other site 875328001268 ATP binding site [chemical binding]; other site 875328001269 Q-loop/lid; other site 875328001270 ABC transporter signature motif; other site 875328001271 Walker B; other site 875328001272 D-loop; other site 875328001273 H-loop/switch region; other site 875328001274 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 875328001275 ligand binding site [chemical binding]; other site 875328001276 flexible hinge region; other site 875328001277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 875328001278 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328001279 PPE family; Region: PPE; pfam00823 875328001280 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328001281 Short C-terminal domain; Region: SHOCT; pfam09851 875328001282 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328001283 PPE family; Region: PPE; pfam00823 875328001284 Cupin superfamily protein; Region: Cupin_4; pfam08007 875328001285 Cupin-like domain; Region: Cupin_8; pfam13621 875328001286 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328001287 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328001288 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 875328001289 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 875328001290 inhibitor-cofactor binding pocket; inhibition site 875328001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328001292 catalytic residue [active] 875328001293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328001294 catalytic core [active] 875328001295 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 875328001296 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328001297 catalytic residues [active] 875328001298 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 875328001299 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 875328001300 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 875328001301 ResB-like family; Region: ResB; pfam05140 875328001302 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 875328001303 AAA domain; Region: AAA_31; pfam13614 875328001304 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 875328001305 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 875328001306 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 875328001307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328001308 acyl-activating enzyme (AAE) consensus motif; other site 875328001309 AMP binding site [chemical binding]; other site 875328001310 active site 875328001311 CoA binding site [chemical binding]; other site 875328001312 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 875328001313 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 875328001314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328001315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 875328001316 active site 875328001317 short chain dehydrogenase; Provisional; Region: PRK05866 875328001318 classical (c) SDRs; Region: SDR_c; cd05233 875328001319 NAD(P) binding site [chemical binding]; other site 875328001320 active site 875328001321 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001322 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 875328001323 substrate binding site [chemical binding]; other site 875328001324 oxyanion hole (OAH) forming residues; other site 875328001325 trimer interface [polypeptide binding]; other site 875328001326 acyl-CoA synthetase; Validated; Region: PRK06188 875328001327 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 875328001328 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328001329 putative active site [active] 875328001330 putative CoA binding site [chemical binding]; other site 875328001331 putative AMP binding site [chemical binding]; other site 875328001332 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328001333 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328001334 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 875328001335 O-succinylbenzoate synthase; Provisional; Region: PRK02901 875328001336 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 875328001337 active site 875328001338 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 875328001339 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328001340 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328001341 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 875328001342 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 875328001343 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 875328001344 dimer interface [polypeptide binding]; other site 875328001345 tetramer interface [polypeptide binding]; other site 875328001346 PYR/PP interface [polypeptide binding]; other site 875328001347 TPP binding site [chemical binding]; other site 875328001348 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 875328001349 TPP-binding site; other site 875328001350 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 875328001351 Thioredoxin; Region: Thioredoxin_4; cl17273 875328001352 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 875328001353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001354 S-adenosylmethionine binding site [chemical binding]; other site 875328001355 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328001356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001357 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328001358 S-adenosylmethionine binding site [chemical binding]; other site 875328001359 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 875328001360 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328001361 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 875328001362 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 875328001363 substrate binding pocket [chemical binding]; other site 875328001364 chain length determination region; other site 875328001365 substrate-Mg2+ binding site; other site 875328001366 catalytic residues [active] 875328001367 aspartate-rich region 1; other site 875328001368 active site lid residues [active] 875328001369 aspartate-rich region 2; other site 875328001370 heat shock protein HtpX; Provisional; Region: PRK03072 875328001371 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 875328001372 Sulfate transporter family; Region: Sulfate_transp; pfam00916 875328001373 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 875328001374 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 875328001375 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 875328001376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328001377 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328001378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 875328001379 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 875328001380 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 875328001381 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328001382 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328001383 active site 875328001384 ATP binding site [chemical binding]; other site 875328001385 substrate binding site [chemical binding]; other site 875328001386 activation loop (A-loop); other site 875328001387 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328001388 Methyltransferase domain; Region: Methyltransf_11; pfam08241 875328001389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328001390 Domain of unknown function (DUF309); Region: DUF309; pfam03745 875328001391 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 875328001392 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 875328001393 dimer interface [polypeptide binding]; other site 875328001394 active site 875328001395 galactokinase; Provisional; Region: PRK00555 875328001396 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 875328001397 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 875328001398 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 875328001399 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 875328001400 putative active site [active] 875328001401 hypothetical protein; Provisional; Region: PRK07588 875328001402 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328001403 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 875328001404 short chain dehydrogenase; Provisional; Region: PRK06197 875328001405 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 875328001406 putative NAD(P) binding site [chemical binding]; other site 875328001407 active site 875328001408 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 875328001409 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 875328001410 Recombinase; Region: Recombinase; pfam07508 875328001411 putative mechanosensitive channel protein; Provisional; Region: PRK10929 875328001412 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 875328001413 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 875328001414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328001415 active site 2 [active] 875328001416 active site 1 [active] 875328001417 ParG; Region: ParG; pfam09274 875328001418 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 875328001419 putative active site [active] 875328001420 hypothetical protein; Validated; Region: PRK00029 875328001421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001422 S-adenosylmethionine binding site [chemical binding]; other site 875328001423 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 875328001424 DoxX-like family; Region: DoxX_2; pfam13564 875328001425 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 875328001426 active site 875328001427 metal binding site [ion binding]; metal-binding site 875328001428 Uncharacterized conserved protein [Function unknown]; Region: COG0397 875328001429 hypothetical protein; Validated; Region: PRK00029 875328001430 Restriction endonuclease; Region: Mrr_cat; pfam04471 875328001431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001432 ATP binding site [chemical binding]; other site 875328001433 putative Mg++ binding site [ion binding]; other site 875328001434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001435 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 875328001436 nucleotide binding region [chemical binding]; other site 875328001437 ATP-binding site [chemical binding]; other site 875328001438 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 875328001439 Predicted transcriptional regulator [Transcription]; Region: COG2378 875328001440 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 875328001441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001442 ATP binding site [chemical binding]; other site 875328001443 putative Mg++ binding site [ion binding]; other site 875328001444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001445 ATP-binding site [chemical binding]; other site 875328001446 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 875328001447 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 875328001448 Part of AAA domain; Region: AAA_19; pfam13245 875328001449 Family description; Region: UvrD_C_2; pfam13538 875328001450 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 875328001451 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 875328001452 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 875328001453 protein binding site [polypeptide binding]; other site 875328001454 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 875328001455 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 875328001456 nucleotide binding site/active site [active] 875328001457 HIT family signature motif; other site 875328001458 catalytic residue [active] 875328001459 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 875328001460 PLD-like domain; Region: PLDc_2; pfam13091 875328001461 putative active site [active] 875328001462 catalytic site [active] 875328001463 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 875328001464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001465 ATP binding site [chemical binding]; other site 875328001466 putative Mg++ binding site [ion binding]; other site 875328001467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001468 nucleotide binding region [chemical binding]; other site 875328001469 ATP-binding site [chemical binding]; other site 875328001470 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 875328001471 Catalytic site [active] 875328001472 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 875328001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328001474 AAA domain; Region: AAA_23; pfam13476 875328001475 Walker A/P-loop; other site 875328001476 ATP binding site [chemical binding]; other site 875328001477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328001478 ABC transporter signature motif; other site 875328001479 Walker B; other site 875328001480 D-loop; other site 875328001481 H-loop/switch region; other site 875328001482 Transposase, Mutator family; Region: Transposase_mut; pfam00872 875328001483 MULE transposase domain; Region: MULE; pfam10551 875328001484 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 875328001485 RNase_H superfamily; Region: RNase_H_2; pfam13482 875328001486 AAA domain; Region: AAA_30; pfam13604 875328001487 AAA domain; Region: AAA_11; pfam13086 875328001488 AAA domain; Region: AAA_12; pfam13087 875328001489 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 875328001490 Helix-turn-helix domain; Region: HTH_17; cl17695 875328001491 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 875328001492 PLD-like domain; Region: PLDc_2; pfam13091 875328001493 putative homodimer interface [polypeptide binding]; other site 875328001494 putative active site [active] 875328001495 catalytic site [active] 875328001496 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 875328001497 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 875328001498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001499 nucleotide binding region [chemical binding]; other site 875328001500 ATP-binding site [chemical binding]; other site 875328001501 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 875328001502 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 875328001503 SEC-C motif; Region: SEC-C; pfam02810 875328001504 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 875328001505 active site 875328001506 metal binding site [ion binding]; metal-binding site 875328001507 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328001508 Cytochrome P450; Region: p450; cl12078 875328001509 Nuclease-related domain; Region: NERD; pfam08378 875328001510 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328001511 Family description; Region: UvrD_C_2; pfam13538 875328001512 SnoaL-like domain; Region: SnoaL_4; pfam13577 875328001513 short chain dehydrogenase; Provisional; Region: PRK08303 875328001514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328001515 NAD(P) binding site [chemical binding]; other site 875328001516 active site 875328001517 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 875328001518 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 875328001519 G1 box; other site 875328001520 putative GEF interaction site [polypeptide binding]; other site 875328001521 GTP/Mg2+ binding site [chemical binding]; other site 875328001522 Switch I region; other site 875328001523 G2 box; other site 875328001524 G3 box; other site 875328001525 Switch II region; other site 875328001526 G4 box; other site 875328001527 G5 box; other site 875328001528 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 875328001529 NYN domain; Region: NYN; pfam01936 875328001530 Uncharacterized conserved protein [Function unknown]; Region: COG1432 875328001531 putative metal binding site [ion binding]; other site 875328001532 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 875328001533 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 875328001534 AAA domain; Region: AAA_30; pfam13604 875328001535 Family description; Region: UvrD_C_2; pfam13538 875328001536 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 875328001537 Part of AAA domain; Region: AAA_19; pfam13245 875328001538 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 875328001539 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 875328001540 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 875328001541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 875328001542 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 875328001543 putative NAD(P) binding site [chemical binding]; other site 875328001544 catalytic Zn binding site [ion binding]; other site 875328001545 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 875328001546 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 875328001547 active site 875328001548 ADP/pyrophosphate binding site [chemical binding]; other site 875328001549 dimerization interface [polypeptide binding]; other site 875328001550 allosteric effector site; other site 875328001551 fructose-1,6-bisphosphate binding site; other site 875328001552 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328001553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001554 S-adenosylmethionine binding site [chemical binding]; other site 875328001555 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 875328001556 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 875328001557 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 875328001558 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328001559 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 875328001560 cyanate hydratase; Validated; Region: PRK02866 875328001561 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 875328001562 oligomer interface [polypeptide binding]; other site 875328001563 active site 875328001564 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 875328001565 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 875328001566 active site 875328001567 nucleophile elbow; other site 875328001568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 875328001569 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 875328001570 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328001571 active site 2 [active] 875328001572 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 875328001573 active site 875328001574 catalytic site [active] 875328001575 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 875328001576 active site 875328001577 catalytic site [active] 875328001578 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 875328001579 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 875328001580 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 875328001581 putative homodimer interface [polypeptide binding]; other site 875328001582 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 875328001583 heterodimer interface [polypeptide binding]; other site 875328001584 homodimer interface [polypeptide binding]; other site 875328001585 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 875328001586 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 875328001587 23S rRNA interface [nucleotide binding]; other site 875328001588 L7/L12 interface [polypeptide binding]; other site 875328001589 putative thiostrepton binding site; other site 875328001590 L25 interface [polypeptide binding]; other site 875328001591 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 875328001592 mRNA/rRNA interface [nucleotide binding]; other site 875328001593 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328001594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328001595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001596 S-adenosylmethionine binding site [chemical binding]; other site 875328001597 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328001598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001599 S-adenosylmethionine binding site [chemical binding]; other site 875328001600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328001601 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 875328001602 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 875328001603 ABC1 family; Region: ABC1; pfam03109 875328001604 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 875328001605 active site 875328001606 ATP binding site [chemical binding]; other site 875328001607 DinB superfamily; Region: DinB_2; pfam12867 875328001608 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 875328001609 active site 875328001610 catalytic site [active] 875328001611 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 875328001612 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 875328001613 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 875328001614 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 875328001615 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 875328001616 PemK-like protein; Region: PemK; pfam02452 875328001617 Predicted transcriptional regulators [Transcription]; Region: COG1733 875328001618 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 875328001619 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 875328001620 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 875328001621 23S rRNA interface [nucleotide binding]; other site 875328001622 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 875328001623 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 875328001624 core dimer interface [polypeptide binding]; other site 875328001625 peripheral dimer interface [polypeptide binding]; other site 875328001626 L10 interface [polypeptide binding]; other site 875328001627 L11 interface [polypeptide binding]; other site 875328001628 putative EF-Tu interaction site [polypeptide binding]; other site 875328001629 putative EF-G interaction site [polypeptide binding]; other site 875328001630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001632 WHG domain; Region: WHG; pfam13305 875328001633 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 875328001634 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 875328001635 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 875328001636 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 875328001637 Walker A/P-loop; other site 875328001638 ATP binding site [chemical binding]; other site 875328001639 Q-loop/lid; other site 875328001640 ABC transporter signature motif; other site 875328001641 Walker B; other site 875328001642 D-loop; other site 875328001643 H-loop/switch region; other site 875328001644 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 875328001645 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 875328001646 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 875328001647 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 875328001648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 875328001649 RPB10 interaction site [polypeptide binding]; other site 875328001650 RPB1 interaction site [polypeptide binding]; other site 875328001651 RPB11 interaction site [polypeptide binding]; other site 875328001652 RPB3 interaction site [polypeptide binding]; other site 875328001653 RPB12 interaction site [polypeptide binding]; other site 875328001654 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 875328001655 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 875328001656 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 875328001657 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 875328001658 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 875328001659 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 875328001660 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 875328001661 G-loop; other site 875328001662 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 875328001663 DNA binding site [nucleotide binding] 875328001664 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 875328001665 endonuclease IV; Provisional; Region: PRK01060 875328001666 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 875328001667 AP (apurinic/apyrimidinic) site pocket; other site 875328001668 DNA interaction; other site 875328001669 Metal-binding active site; metal-binding site 875328001670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001672 active site 875328001673 enoyl-CoA hydratase; Provisional; Region: PRK12478 875328001674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001675 substrate binding site [chemical binding]; other site 875328001676 oxyanion hole (OAH) forming residues; other site 875328001677 trimer interface [polypeptide binding]; other site 875328001678 PaaX-like protein; Region: PaaX; pfam07848 875328001679 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 875328001680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328001681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001682 substrate binding site [chemical binding]; other site 875328001683 oxyanion hole (OAH) forming residues; other site 875328001684 trimer interface [polypeptide binding]; other site 875328001685 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 875328001686 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 875328001687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001689 WHG domain; Region: WHG; pfam13305 875328001690 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 875328001691 S17 interaction site [polypeptide binding]; other site 875328001692 S8 interaction site; other site 875328001693 16S rRNA interaction site [nucleotide binding]; other site 875328001694 streptomycin interaction site [chemical binding]; other site 875328001695 23S rRNA interaction site [nucleotide binding]; other site 875328001696 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 875328001697 30S ribosomal protein S7; Validated; Region: PRK05302 875328001698 elongation factor G; Reviewed; Region: PRK00007 875328001699 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 875328001700 G1 box; other site 875328001701 putative GEF interaction site [polypeptide binding]; other site 875328001702 GTP/Mg2+ binding site [chemical binding]; other site 875328001703 Switch I region; other site 875328001704 G2 box; other site 875328001705 G3 box; other site 875328001706 Switch II region; other site 875328001707 G4 box; other site 875328001708 G5 box; other site 875328001709 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 875328001710 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 875328001711 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 875328001712 elongation factor Tu; Reviewed; Region: PRK00049 875328001713 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 875328001714 G1 box; other site 875328001715 GEF interaction site [polypeptide binding]; other site 875328001716 GTP/Mg2+ binding site [chemical binding]; other site 875328001717 Switch I region; other site 875328001718 G2 box; other site 875328001719 G3 box; other site 875328001720 Switch II region; other site 875328001721 G4 box; other site 875328001722 G5 box; other site 875328001723 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 875328001724 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 875328001725 Antibiotic Binding Site [chemical binding]; other site 875328001726 Short C-terminal domain; Region: SHOCT; pfam09851 875328001727 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328001728 classical (c) SDRs; Region: SDR_c; cd05233 875328001729 NAD(P) binding site [chemical binding]; other site 875328001730 active site 875328001731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 875328001732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328001733 Phosphotransferase enzyme family; Region: APH; pfam01636 875328001734 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328001735 putative active site [active] 875328001736 putative substrate binding site [chemical binding]; other site 875328001737 ATP binding site [chemical binding]; other site 875328001738 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 875328001739 classical (c) SDRs; Region: SDR_c; cd05233 875328001740 NAD(P) binding site [chemical binding]; other site 875328001741 active site 875328001742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001744 active site 875328001745 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001747 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 875328001748 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 875328001749 NAD(P) binding site [chemical binding]; other site 875328001750 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 875328001751 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328001752 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 875328001753 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328001754 Phosphotransferase enzyme family; Region: APH; pfam01636 875328001755 Ecdysteroid kinase; Region: EcKinase; cl17738 875328001756 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328001757 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001758 substrate binding site [chemical binding]; other site 875328001759 oxyanion hole (OAH) forming residues; other site 875328001760 trimer interface [polypeptide binding]; other site 875328001761 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328001762 Permease; Region: Permease; pfam02405 875328001763 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328001764 Permease; Region: Permease; pfam02405 875328001765 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 875328001766 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 875328001767 B12 binding site [chemical binding]; other site 875328001768 cobalt ligand [ion binding]; other site 875328001769 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 875328001770 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328001771 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328001772 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328001773 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 875328001774 homotetrameric interface [polypeptide binding]; other site 875328001775 putative active site [active] 875328001776 metal binding site [ion binding]; metal-binding site 875328001777 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 875328001778 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328001779 active site 875328001780 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328001781 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328001782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001784 enoyl-CoA hydratase; Provisional; Region: PRK08290 875328001785 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001786 substrate binding site [chemical binding]; other site 875328001787 oxyanion hole (OAH) forming residues; other site 875328001788 trimer interface [polypeptide binding]; other site 875328001789 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 875328001790 Phosphotransferase enzyme family; Region: APH; pfam01636 875328001791 putative active site [active] 875328001792 putative substrate binding site [chemical binding]; other site 875328001793 ATP binding site [chemical binding]; other site 875328001794 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 875328001795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328001796 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328001797 acyl-activating enzyme (AAE) consensus motif; other site 875328001798 acyl-activating enzyme (AAE) consensus motif; other site 875328001799 putative AMP binding site [chemical binding]; other site 875328001800 putative active site [active] 875328001801 putative CoA binding site [chemical binding]; other site 875328001802 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 875328001803 classical (c) SDRs; Region: SDR_c; cd05233 875328001804 NAD(P) binding site [chemical binding]; other site 875328001805 active site 875328001806 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 875328001807 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 875328001808 acyl-activating enzyme (AAE) consensus motif; other site 875328001809 putative AMP binding site [chemical binding]; other site 875328001810 putative active site [active] 875328001811 putative CoA binding site [chemical binding]; other site 875328001812 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 875328001813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328001814 DNA-binding site [nucleotide binding]; DNA binding site 875328001815 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 875328001816 PQQ-like domain; Region: PQQ_2; pfam13360 875328001817 Strictosidine synthase; Region: Str_synth; pfam03088 875328001818 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328001819 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328001820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001822 active site 875328001823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001825 active site 875328001826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001828 active site 875328001829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001830 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001831 active site 875328001832 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 875328001833 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 875328001834 PYR/PP interface [polypeptide binding]; other site 875328001835 dimer interface [polypeptide binding]; other site 875328001836 TPP binding site [chemical binding]; other site 875328001837 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 875328001838 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 875328001839 TPP-binding site; other site 875328001840 dimer interface [polypeptide binding]; other site 875328001841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001843 active site 875328001844 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328001845 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328001846 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328001847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001848 substrate binding site [chemical binding]; other site 875328001849 oxyanion hole (OAH) forming residues; other site 875328001850 trimer interface [polypeptide binding]; other site 875328001851 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 875328001852 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328001853 dimer interface [polypeptide binding]; other site 875328001854 active site 875328001855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328001856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001857 active site 875328001858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328001859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328001860 Predicted membrane protein [Function unknown]; Region: COG2259 875328001861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 875328001862 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 875328001863 acyl-activating enzyme (AAE) consensus motif; other site 875328001864 putative AMP binding site [chemical binding]; other site 875328001865 putative active site [active] 875328001866 putative CoA binding site [chemical binding]; other site 875328001867 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328001868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001869 substrate binding site [chemical binding]; other site 875328001870 oxyanion hole (OAH) forming residues; other site 875328001871 trimer interface [polypeptide binding]; other site 875328001872 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328001873 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328001874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328001875 active site 875328001876 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328001877 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328001878 multiple promoter invertase; Provisional; Region: mpi; PRK13413 875328001879 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 875328001880 catalytic residues [active] 875328001881 catalytic nucleophile [active] 875328001882 Presynaptic Site I dimer interface [polypeptide binding]; other site 875328001883 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 875328001884 Synaptic Flat tetramer interface [polypeptide binding]; other site 875328001885 Synaptic Site I dimer interface [polypeptide binding]; other site 875328001886 DNA binding site [nucleotide binding] 875328001887 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 875328001888 DNA-binding interface [nucleotide binding]; DNA binding site 875328001889 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 875328001890 Protein of unknown function (DUF499); Region: DUF499; pfam04465 875328001891 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 875328001892 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 875328001893 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 875328001894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001895 ATP binding site [chemical binding]; other site 875328001896 putative Mg++ binding site [ion binding]; other site 875328001897 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 875328001898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001899 nucleotide binding region [chemical binding]; other site 875328001900 ATP-binding site [chemical binding]; other site 875328001901 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 875328001902 Helix-turn-helix domain; Region: HTH_17; pfam12728 875328001903 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 875328001904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 875328001905 active site 875328001906 DNA binding site [nucleotide binding] 875328001907 Int/Topo IB signature motif; other site 875328001908 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 875328001909 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 875328001910 Int/Topo IB signature motif; other site 875328001911 Helix-turn-helix domain; Region: HTH_17; pfam12728 875328001912 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 875328001913 putative transposase OrfB; Reviewed; Region: PHA02517 875328001914 HTH-like domain; Region: HTH_21; pfam13276 875328001915 Integrase core domain; Region: rve; pfam00665 875328001916 Integrase core domain; Region: rve_3; pfam13683 875328001917 Transposase; Region: HTH_Tnp_1; pfam01527 875328001918 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 875328001919 PLD-like domain; Region: PLDc_2; pfam13091 875328001920 putative homodimer interface [polypeptide binding]; other site 875328001921 putative active site [active] 875328001922 catalytic site [active] 875328001923 DEAD-like helicases superfamily; Region: DEXDc; smart00487 875328001924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001925 ATP binding site [chemical binding]; other site 875328001926 putative Mg++ binding site [ion binding]; other site 875328001927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001928 ATP-binding site [chemical binding]; other site 875328001929 Winged helix-turn helix; Region: HTH_29; pfam13551 875328001930 Helix-turn-helix domain; Region: HTH_28; pfam13518 875328001931 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 875328001932 putative hydrophobic ligand binding site [chemical binding]; other site 875328001933 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 875328001934 putative hydrophobic ligand binding site [chemical binding]; other site 875328001935 aminotransferase; Validated; Region: PRK07777 875328001936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328001937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328001938 homodimer interface [polypeptide binding]; other site 875328001939 catalytic residue [active] 875328001940 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 875328001941 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328001942 dimer interface [polypeptide binding]; other site 875328001943 active site 875328001944 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 875328001945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328001946 substrate binding site [chemical binding]; other site 875328001947 oxyanion hole (OAH) forming residues; other site 875328001948 trimer interface [polypeptide binding]; other site 875328001949 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 875328001950 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 875328001951 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 875328001952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328001953 S-adenosylmethionine binding site [chemical binding]; other site 875328001954 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 875328001955 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 875328001956 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 875328001957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 875328001958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328001959 ATP binding site [chemical binding]; other site 875328001960 putative Mg++ binding site [ion binding]; other site 875328001961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328001962 nucleotide binding region [chemical binding]; other site 875328001963 ATP-binding site [chemical binding]; other site 875328001964 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 875328001965 WYL domain; Region: WYL; pfam13280 875328001966 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 875328001967 trimer interface [polypeptide binding]; other site 875328001968 dimer interface [polypeptide binding]; other site 875328001969 putative active site [active] 875328001970 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 875328001971 MPT binding site; other site 875328001972 trimer interface [polypeptide binding]; other site 875328001973 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 875328001974 MoaE homodimer interface [polypeptide binding]; other site 875328001975 MoaD interaction [polypeptide binding]; other site 875328001976 active site residues [active] 875328001977 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 875328001978 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 875328001979 MoaE interaction surface [polypeptide binding]; other site 875328001980 thiocarboxylated glycine; other site 875328001981 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 875328001982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328001983 FeS/SAM binding site; other site 875328001984 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 875328001985 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 875328001986 DNA-binding site [nucleotide binding]; DNA binding site 875328001987 RNA-binding motif; other site 875328001988 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328001989 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 875328001990 active site 875328001991 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 875328001992 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 875328001993 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 875328001994 putative dimer interface [polypeptide binding]; other site 875328001995 N-terminal domain interface [polypeptide binding]; other site 875328001996 putative substrate binding pocket (H-site) [chemical binding]; other site 875328001997 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 875328001998 H+ Antiporter protein; Region: 2A0121; TIGR00900 875328001999 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 875328002000 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 875328002001 hydrophobic ligand binding site; other site 875328002002 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 875328002003 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 875328002004 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 875328002005 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 875328002006 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 875328002007 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328002008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328002009 catalytic residue [active] 875328002010 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 875328002011 Ferredoxin [Energy production and conversion]; Region: COG1146 875328002012 4Fe-4S binding domain; Region: Fer4; pfam00037 875328002013 ferredoxin-NADP+ reductase; Region: PLN02852 875328002014 citrate synthase 2; Provisional; Region: PRK12350 875328002015 Citrate synthase; Region: Citrate_synt; pfam00285 875328002016 oxalacetate binding site [chemical binding]; other site 875328002017 citrylCoA binding site [chemical binding]; other site 875328002018 coenzyme A binding site [chemical binding]; other site 875328002019 catalytic triad [active] 875328002020 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 875328002021 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 875328002022 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 875328002023 enterobactin exporter EntS; Provisional; Region: PRK10489 875328002024 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 875328002025 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 875328002026 dimer interface [polypeptide binding]; other site 875328002027 active site 875328002028 citrylCoA binding site [chemical binding]; other site 875328002029 NADH binding [chemical binding]; other site 875328002030 cationic pore residues; other site 875328002031 oxalacetate/citrate binding site [chemical binding]; other site 875328002032 coenzyme A binding site [chemical binding]; other site 875328002033 catalytic triad [active] 875328002034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 875328002035 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 875328002036 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 875328002037 ligand binding site [chemical binding]; other site 875328002038 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 875328002039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 875328002040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328002041 dimerization interface [polypeptide binding]; other site 875328002042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328002043 dimer interface [polypeptide binding]; other site 875328002044 phosphorylation site [posttranslational modification] 875328002045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328002046 Mg2+ binding site [ion binding]; other site 875328002047 G-X-G motif; other site 875328002048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328002049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328002050 active site 875328002051 phosphorylation site [posttranslational modification] 875328002052 intermolecular recognition site; other site 875328002053 dimerization interface [polypeptide binding]; other site 875328002054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328002055 DNA binding site [nucleotide binding] 875328002056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 875328002057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 875328002058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328002059 Walker A/P-loop; other site 875328002060 ATP binding site [chemical binding]; other site 875328002061 Q-loop/lid; other site 875328002062 ABC transporter signature motif; other site 875328002063 Walker B; other site 875328002064 D-loop; other site 875328002065 H-loop/switch region; other site 875328002066 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 875328002067 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 875328002068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328002069 Walker A/P-loop; other site 875328002070 ATP binding site [chemical binding]; other site 875328002071 Q-loop/lid; other site 875328002072 ABC transporter signature motif; other site 875328002073 Walker B; other site 875328002074 D-loop; other site 875328002075 H-loop/switch region; other site 875328002076 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 875328002077 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328002078 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328002079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002080 substrate binding site [chemical binding]; other site 875328002081 oxyanion hole (OAH) forming residues; other site 875328002082 trimer interface [polypeptide binding]; other site 875328002083 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 875328002084 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 875328002085 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 875328002086 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328002087 Soluble P-type ATPase [General function prediction only]; Region: COG4087 875328002088 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 875328002089 hydrophobic ligand binding site; other site 875328002090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 875328002091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328002092 Walker A/P-loop; other site 875328002093 ATP binding site [chemical binding]; other site 875328002094 Q-loop/lid; other site 875328002095 ABC transporter signature motif; other site 875328002096 Walker B; other site 875328002097 D-loop; other site 875328002098 H-loop/switch region; other site 875328002099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328002100 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 875328002101 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328002102 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 875328002103 putative active site pocket [active] 875328002104 dimerization interface [polypeptide binding]; other site 875328002105 putative catalytic residue [active] 875328002106 Protein of unknown function (DUF867); Region: DUF867; pfam05908 875328002107 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 875328002108 Uncharacterized conserved protein [Function unknown]; Region: COG5361 875328002109 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 875328002110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002112 Emopamil binding protein; Region: EBP; pfam05241 875328002113 Predicted transcriptional regulators [Transcription]; Region: COG1733 875328002114 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 875328002115 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 875328002116 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328002117 molybdopterin cofactor binding site; other site 875328002118 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 875328002119 molybdopterin cofactor binding site; other site 875328002120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328002121 sequence-specific DNA binding site [nucleotide binding]; other site 875328002122 salt bridge; other site 875328002123 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 875328002124 HipA-like N-terminal domain; Region: HipA_N; pfam07805 875328002125 HipA-like C-terminal domain; Region: HipA_C; pfam07804 875328002126 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328002127 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328002128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002129 NADH(P)-binding; Region: NAD_binding_10; pfam13460 875328002130 NAD(P) binding site [chemical binding]; other site 875328002131 active site 875328002132 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 875328002133 4Fe-4S binding domain; Region: Fer4_6; pfam12837 875328002134 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 875328002135 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 875328002136 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 875328002137 putative hydrophobic ligand binding site [chemical binding]; other site 875328002138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002139 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 875328002140 NAD(P) binding site [chemical binding]; other site 875328002141 active site 875328002142 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 875328002143 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328002144 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328002145 active site 875328002146 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 875328002147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328002148 active site 875328002149 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 875328002150 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328002151 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328002152 acyl-activating enzyme (AAE) consensus motif; other site 875328002153 acyl-activating enzyme (AAE) consensus motif; other site 875328002154 putative AMP binding site [chemical binding]; other site 875328002155 putative active site [active] 875328002156 putative CoA binding site [chemical binding]; other site 875328002157 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328002158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002159 substrate binding site [chemical binding]; other site 875328002160 oxyanion hole (OAH) forming residues; other site 875328002161 trimer interface [polypeptide binding]; other site 875328002162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002166 Predicted membrane protein [Function unknown]; Region: COG4270 875328002167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328002168 dimerization interface [polypeptide binding]; other site 875328002169 putative DNA binding site [nucleotide binding]; other site 875328002170 putative Zn2+ binding site [ion binding]; other site 875328002171 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 875328002172 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328002173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 875328002174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328002175 motif II; other site 875328002176 ANTAR domain; Region: ANTAR; cl04297 875328002177 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 875328002178 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 875328002179 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 875328002180 putative di-iron ligands [ion binding]; other site 875328002181 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 875328002182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 875328002183 active site 875328002184 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328002185 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 875328002186 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 875328002187 Moco binding site; other site 875328002188 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 875328002189 metal coordination site [ion binding]; other site 875328002190 CrcB-like protein; Region: CRCB; pfam02537 875328002191 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 875328002192 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 875328002193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328002194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328002195 active site 875328002196 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 875328002197 classical (c) SDRs; Region: SDR_c; cd05233 875328002198 NAD(P) binding site [chemical binding]; other site 875328002199 active site 875328002200 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 875328002201 putative hydrophobic ligand binding site [chemical binding]; other site 875328002202 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 875328002203 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 875328002204 homodimer interface [polypeptide binding]; other site 875328002205 putative substrate binding pocket [chemical binding]; other site 875328002206 diiron center [ion binding]; other site 875328002207 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 875328002208 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 875328002209 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328002210 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 875328002211 short chain dehydrogenase; Provisional; Region: PRK07814 875328002212 classical (c) SDRs; Region: SDR_c; cd05233 875328002213 NAD(P) binding site [chemical binding]; other site 875328002214 active site 875328002215 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328002216 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328002217 active site 875328002218 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328002219 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328002220 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 875328002221 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 875328002222 nucleotide binding site [chemical binding]; other site 875328002223 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 875328002224 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 875328002225 active site 875328002226 DNA binding site [nucleotide binding] 875328002227 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 875328002228 DNA binding site [nucleotide binding] 875328002229 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 875328002230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 875328002231 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 875328002232 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 875328002233 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328002234 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328002235 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 875328002236 Predicted membrane protein [Function unknown]; Region: COG1950 875328002237 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 875328002238 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 875328002239 putative DNA binding site [nucleotide binding]; other site 875328002240 catalytic residue [active] 875328002241 putative H2TH interface [polypeptide binding]; other site 875328002242 putative catalytic residues [active] 875328002243 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 875328002244 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 875328002245 short chain dehydrogenase; Provisional; Region: PRK08251 875328002246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002247 NAD(P) binding site [chemical binding]; other site 875328002248 active site 875328002249 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 875328002250 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 875328002251 active site 875328002252 dimer interface [polypeptide binding]; other site 875328002253 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 875328002254 dimer interface [polypeptide binding]; other site 875328002255 active site 875328002256 hypothetical protein; Provisional; Region: PRK07857 875328002257 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 875328002258 Part of AAA domain; Region: AAA_19; pfam13245 875328002259 Family description; Region: UvrD_C_2; pfam13538 875328002260 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 875328002261 Peptidase family M23; Region: Peptidase_M23; pfam01551 875328002262 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 875328002263 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 875328002264 CoA-ligase; Region: Ligase_CoA; pfam00549 875328002265 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 875328002266 CoA binding domain; Region: CoA_binding; smart00881 875328002267 CoA-ligase; Region: Ligase_CoA; pfam00549 875328002268 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 875328002269 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 875328002270 active site 875328002271 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328002272 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328002273 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 875328002274 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 875328002275 active site 875328002276 substrate binding site [chemical binding]; other site 875328002277 cosubstrate binding site; other site 875328002278 catalytic site [active] 875328002279 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 875328002280 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 875328002281 purine monophosphate binding site [chemical binding]; other site 875328002282 dimer interface [polypeptide binding]; other site 875328002283 putative catalytic residues [active] 875328002284 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 875328002285 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 875328002286 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 875328002287 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328002288 active site 875328002289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328002290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002291 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328002292 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 875328002293 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 875328002294 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 875328002295 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 875328002296 metal ion-dependent adhesion site (MIDAS); other site 875328002297 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002298 PPE family; Region: PPE; pfam00823 875328002299 Short C-terminal domain; Region: SHOCT; pfam09851 875328002300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328002301 dimerization interface [polypeptide binding]; other site 875328002302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 875328002303 Histidine kinase; Region: HisKA_3; pfam07730 875328002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328002305 ATP binding site [chemical binding]; other site 875328002306 Mg2+ binding site [ion binding]; other site 875328002307 G-X-G motif; other site 875328002308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328002310 active site 875328002311 phosphorylation site [posttranslational modification] 875328002312 intermolecular recognition site; other site 875328002313 dimerization interface [polypeptide binding]; other site 875328002314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328002315 DNA binding residues [nucleotide binding] 875328002316 dimerization interface [polypeptide binding]; other site 875328002317 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 875328002318 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 875328002319 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328002320 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 875328002321 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 875328002322 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 875328002323 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 875328002324 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328002325 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 875328002326 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 875328002327 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 875328002328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328002329 S-adenosylmethionine binding site [chemical binding]; other site 875328002330 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 875328002331 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328002332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002334 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 875328002335 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 875328002336 enoyl-CoA hydratase; Provisional; Region: PRK07827 875328002337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002338 substrate binding site [chemical binding]; other site 875328002339 oxyanion hole (OAH) forming residues; other site 875328002340 trimer interface [polypeptide binding]; other site 875328002341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328002342 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328002343 active site 875328002344 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 875328002345 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328002346 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328002347 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 875328002348 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328002349 carboxyltransferase (CT) interaction site; other site 875328002350 biotinylation site [posttranslational modification]; other site 875328002351 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328002352 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328002353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328002354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328002355 active site 875328002356 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 875328002357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328002359 active site 875328002360 phosphorylation site [posttranslational modification] 875328002361 intermolecular recognition site; other site 875328002362 dimerization interface [polypeptide binding]; other site 875328002363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328002364 DNA binding site [nucleotide binding] 875328002365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 875328002366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328002367 dimerization interface [polypeptide binding]; other site 875328002368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328002369 dimer interface [polypeptide binding]; other site 875328002370 phosphorylation site [posttranslational modification] 875328002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328002372 ATP binding site [chemical binding]; other site 875328002373 Mg2+ binding site [ion binding]; other site 875328002374 G-X-G motif; other site 875328002375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 875328002376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 875328002377 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 875328002378 MPT binding site; other site 875328002379 trimer interface [polypeptide binding]; other site 875328002380 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 875328002381 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 875328002382 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 875328002383 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 875328002384 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 875328002385 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 875328002386 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 875328002387 active site 875328002388 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 875328002389 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 875328002390 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 875328002391 dimer interface [polypeptide binding]; other site 875328002392 putative functional site; other site 875328002393 putative MPT binding site; other site 875328002394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 875328002395 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 875328002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 875328002397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328002400 Cytochrome P450; Region: p450; cl12078 875328002401 EcsC protein family; Region: EcsC; pfam12787 875328002402 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328002403 glutamate dehydrogenase; Provisional; Region: PRK09414 875328002404 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 875328002405 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 875328002406 NAD(P) binding site [chemical binding]; other site 875328002407 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 875328002408 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 875328002409 ligand binding site [chemical binding]; other site 875328002410 flexible hinge region; other site 875328002411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 875328002412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328002413 Coenzyme A binding pocket [chemical binding]; other site 875328002414 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 875328002415 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 875328002416 Predicted methyltransferases [General function prediction only]; Region: COG0313 875328002417 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 875328002418 putative SAM binding site [chemical binding]; other site 875328002419 putative homodimer interface [polypeptide binding]; other site 875328002420 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 875328002421 chorismate binding enzyme; Region: Chorismate_bind; cl10555 875328002422 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 875328002423 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 875328002424 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 875328002425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328002426 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 875328002427 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 875328002428 active site 875328002429 HIGH motif; other site 875328002430 KMSKS motif; other site 875328002431 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 875328002432 tRNA binding surface [nucleotide binding]; other site 875328002433 anticodon binding site; other site 875328002434 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 875328002435 active site 875328002436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 875328002437 Domain of unknown function (DUF348); Region: DUF348; pfam03990 875328002438 Domain of unknown function (DUF348); Region: DUF348; pfam03990 875328002439 G5 domain; Region: G5; pfam07501 875328002440 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 875328002441 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 875328002442 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 875328002443 PE-PPE domain; Region: PE-PPE; pfam08237 875328002444 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 875328002445 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 875328002446 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328002447 acyl-activating enzyme (AAE) consensus motif; other site 875328002448 active site 875328002449 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 875328002450 putative active site [active] 875328002451 catalytic residue [active] 875328002452 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 875328002453 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 875328002454 5S rRNA interface [nucleotide binding]; other site 875328002455 CTC domain interface [polypeptide binding]; other site 875328002456 L16 interface [polypeptide binding]; other site 875328002457 PPE family; Region: PPE; pfam00823 875328002458 EspG family; Region: ESX-1_EspG; pfam14011 875328002459 short chain dehydrogenase; Provisional; Region: PRK06197 875328002460 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 875328002461 putative NAD(P) binding site [chemical binding]; other site 875328002462 active site 875328002463 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 875328002464 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 875328002465 ArsC family; Region: ArsC; pfam03960 875328002466 catalytic residues [active] 875328002467 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 875328002468 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 875328002469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328002470 active site 875328002471 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 875328002472 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 875328002473 Substrate binding site; other site 875328002474 Mg++ binding site; other site 875328002475 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 875328002476 active site 875328002477 substrate binding site [chemical binding]; other site 875328002478 CoA binding site [chemical binding]; other site 875328002479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002481 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 875328002482 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 875328002483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328002484 ATP binding site [chemical binding]; other site 875328002485 putative Mg++ binding site [ion binding]; other site 875328002486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328002487 nucleotide binding region [chemical binding]; other site 875328002488 ATP-binding site [chemical binding]; other site 875328002489 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 875328002490 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 875328002491 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 875328002492 homodimer interface [polypeptide binding]; other site 875328002493 metal binding site [ion binding]; metal-binding site 875328002494 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002495 PPE family; Region: PPE; pfam00823 875328002496 Predicted integral membrane protein [Function unknown]; Region: COG5660 875328002497 Putative zinc-finger; Region: zf-HC2; pfam13490 875328002498 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 875328002499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328002500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328002501 DNA binding residues [nucleotide binding] 875328002502 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 875328002503 N-acetyl-D-glucosamine binding site [chemical binding]; other site 875328002504 enolase; Provisional; Region: eno; PRK00077 875328002505 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 875328002506 dimer interface [polypeptide binding]; other site 875328002507 metal binding site [ion binding]; metal-binding site 875328002508 substrate binding pocket [chemical binding]; other site 875328002509 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 875328002510 Septum formation initiator; Region: DivIC; pfam04977 875328002511 Uncharacterized conserved protein [Function unknown]; Region: COG1507 875328002512 exopolyphosphatase; Region: exo_poly_only; TIGR03706 875328002513 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 875328002514 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 875328002515 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 875328002516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328002517 active site 875328002518 phosphorylation site [posttranslational modification] 875328002519 intermolecular recognition site; other site 875328002520 dimerization interface [polypeptide binding]; other site 875328002521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328002522 DNA binding site [nucleotide binding] 875328002523 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 875328002524 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 875328002525 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 875328002526 Ligand Binding Site [chemical binding]; other site 875328002527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328002528 dimer interface [polypeptide binding]; other site 875328002529 phosphorylation site [posttranslational modification] 875328002530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328002531 ATP binding site [chemical binding]; other site 875328002532 Mg2+ binding site [ion binding]; other site 875328002533 G-X-G motif; other site 875328002534 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002535 PPE family; Region: PPE; pfam00823 875328002536 PE family; Region: PE; pfam00934 875328002537 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002538 PPE family; Region: PPE; pfam00823 875328002539 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328002540 PE family; Region: PE; pfam00934 875328002541 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328002542 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328002543 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002544 PPE family; Region: PPE; pfam00823 875328002545 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328002546 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002547 PPE family; Region: PPE; pfam00823 875328002548 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328002549 PE family; Region: PE; pfam00934 875328002550 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328002551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328002552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328002553 S-adenosylmethionine binding site [chemical binding]; other site 875328002554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328002555 putative DNA binding site [nucleotide binding]; other site 875328002556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 875328002557 putative Zn2+ binding site [ion binding]; other site 875328002558 Uncharacterized conserved protein [Function unknown]; Region: COG3391 875328002559 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 875328002560 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 875328002561 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 875328002562 dimer interface [polypeptide binding]; other site 875328002563 acyl-activating enzyme (AAE) consensus motif; other site 875328002564 putative active site [active] 875328002565 AMP binding site [chemical binding]; other site 875328002566 putative CoA binding site [chemical binding]; other site 875328002567 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328002568 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 875328002569 Patatin-like phospholipase; Region: Patatin; pfam01734 875328002570 active site 875328002571 nucleophile elbow; other site 875328002572 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 875328002573 hypothetical protein; Provisional; Region: PRK10279 875328002574 active site 875328002575 nucleophile elbow; other site 875328002576 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 875328002577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 875328002578 active site residue [active] 875328002579 Predicted membrane protein [Function unknown]; Region: COG4425 875328002580 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 875328002581 enoyl-CoA hydratase; Provisional; Region: PRK05862 875328002582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002583 substrate binding site [chemical binding]; other site 875328002584 oxyanion hole (OAH) forming residues; other site 875328002585 trimer interface [polypeptide binding]; other site 875328002586 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 875328002587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002588 substrate binding site [chemical binding]; other site 875328002589 oxyanion hole (OAH) forming residues; other site 875328002590 trimer interface [polypeptide binding]; other site 875328002591 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 875328002592 Bax inhibitor 1 like; Region: BaxI_1; cl17691 875328002593 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 875328002594 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328002595 dimer interface [polypeptide binding]; other site 875328002596 active site 875328002597 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 875328002598 active site 875328002599 catalytic triad [active] 875328002600 oxyanion hole [active] 875328002601 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 875328002602 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 875328002603 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 875328002604 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 875328002605 dimer interface [polypeptide binding]; other site 875328002606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328002607 catalytic residue [active] 875328002608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 875328002609 RDD family; Region: RDD; pfam06271 875328002610 cystathionine gamma-synthase; Provisional; Region: PRK07811 875328002611 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 875328002612 homodimer interface [polypeptide binding]; other site 875328002613 substrate-cofactor binding pocket; other site 875328002614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328002615 catalytic residue [active] 875328002616 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 875328002617 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 875328002618 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 875328002619 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 875328002620 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 875328002621 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 875328002622 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 875328002623 catalytic residues [active] 875328002624 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328002625 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 875328002626 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 875328002627 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 875328002628 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 875328002629 catalytic residue [active] 875328002630 putative FPP diphosphate binding site; other site 875328002631 putative FPP binding hydrophobic cleft; other site 875328002632 dimer interface [polypeptide binding]; other site 875328002633 putative IPP diphosphate binding site; other site 875328002634 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328002635 pantothenate kinase; Provisional; Region: PRK05439 875328002636 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 875328002637 ATP-binding site [chemical binding]; other site 875328002638 CoA-binding site [chemical binding]; other site 875328002639 Mg2+-binding site [ion binding]; other site 875328002640 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 875328002641 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 875328002642 dimer interface [polypeptide binding]; other site 875328002643 active site 875328002644 glycine-pyridoxal phosphate binding site [chemical binding]; other site 875328002645 folate binding site [chemical binding]; other site 875328002646 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 875328002647 dinuclear metal binding motif [ion binding]; other site 875328002648 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 875328002649 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 875328002650 putative active site [active] 875328002651 PhoH-like protein; Region: PhoH; pfam02562 875328002652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002654 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 875328002655 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 875328002656 NodB motif; other site 875328002657 active site 875328002658 catalytic site [active] 875328002659 metal binding site [ion binding]; metal-binding site 875328002660 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 875328002661 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328002662 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328002663 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328002664 active site 875328002665 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 875328002666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002668 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 875328002669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328002670 putative substrate translocation pore; other site 875328002671 fumarate hydratase; Reviewed; Region: fumC; PRK00485 875328002672 Class II fumarases; Region: Fumarase_classII; cd01362 875328002673 active site 875328002674 tetramer interface [polypeptide binding]; other site 875328002675 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 875328002676 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 875328002677 putative active site [active] 875328002678 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 875328002679 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 875328002680 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 875328002681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328002683 NAD(P) binding site [chemical binding]; other site 875328002684 active site 875328002685 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 875328002686 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 875328002687 putative NAD(P) binding site [chemical binding]; other site 875328002688 active site 875328002689 putative substrate binding site [chemical binding]; other site 875328002690 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 875328002691 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 875328002692 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 875328002693 generic binding surface II; other site 875328002694 generic binding surface I; other site 875328002695 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 875328002696 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 875328002697 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 875328002698 GTP-binding protein YchF; Reviewed; Region: PRK09601 875328002699 YchF GTPase; Region: YchF; cd01900 875328002700 G1 box; other site 875328002701 GTP/Mg2+ binding site [chemical binding]; other site 875328002702 Switch I region; other site 875328002703 G2 box; other site 875328002704 Switch II region; other site 875328002705 G3 box; other site 875328002706 G4 box; other site 875328002707 G5 box; other site 875328002708 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 875328002709 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 875328002710 OsmC-like protein; Region: OsmC; pfam02566 875328002711 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 875328002712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 875328002713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 875328002714 dimerization interface [polypeptide binding]; other site 875328002715 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 875328002716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328002717 Uncharacterized conserved protein [Function unknown]; Region: COG1359 875328002718 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328002719 cyclase homology domain; Region: CHD; cd07302 875328002720 nucleotidyl binding site; other site 875328002721 metal binding site [ion binding]; metal-binding site 875328002722 dimer interface [polypeptide binding]; other site 875328002723 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328002724 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328002725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328002726 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328002727 Predicted membrane protein [Function unknown]; Region: COG2259 875328002728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328002729 sequence-specific DNA binding site [nucleotide binding]; other site 875328002730 salt bridge; other site 875328002731 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 875328002732 Domain of unknown function (DUF955); Region: DUF955; pfam06114 875328002733 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 875328002734 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 875328002735 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 875328002736 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 875328002737 tetramer interface [polypeptide binding]; other site 875328002738 active site 875328002739 Mg2+/Mn2+ binding site [ion binding]; other site 875328002740 citrate synthase; Provisional; Region: PRK14033 875328002741 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 875328002742 oxalacetate binding site [chemical binding]; other site 875328002743 citrylCoA binding site [chemical binding]; other site 875328002744 coenzyme A binding site [chemical binding]; other site 875328002745 catalytic triad [active] 875328002746 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328002747 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 875328002748 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 875328002749 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328002750 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 875328002751 enoyl-CoA hydratase; Provisional; Region: PRK08260 875328002752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002753 substrate binding site [chemical binding]; other site 875328002754 oxyanion hole (OAH) forming residues; other site 875328002755 trimer interface [polypeptide binding]; other site 875328002756 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 875328002757 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 875328002758 THF binding site; other site 875328002759 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 875328002760 substrate binding site [chemical binding]; other site 875328002761 THF binding site; other site 875328002762 zinc-binding site [ion binding]; other site 875328002763 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 875328002764 NADH(P)-binding; Region: NAD_binding_10; pfam13460 875328002765 NAD(P) binding site [chemical binding]; other site 875328002766 putative active site [active] 875328002767 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 875328002768 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328002769 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328002770 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 875328002771 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328002772 classical (c) SDRs; Region: SDR_c; cd05233 875328002773 NAD(P) binding site [chemical binding]; other site 875328002774 active site 875328002775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002779 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328002780 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 875328002781 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002782 mce related protein; Region: MCE; pfam02470 875328002783 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002784 mce related protein; Region: MCE; pfam02470 875328002785 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002786 mce related protein; Region: MCE; pfam02470 875328002787 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002788 mce related protein; Region: MCE; pfam02470 875328002789 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002790 mce related protein; Region: MCE; pfam02470 875328002791 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328002792 mce related protein; Region: MCE; pfam02470 875328002793 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328002794 Permease; Region: Permease; pfam02405 875328002795 Permease; Region: Permease; pfam02405 875328002796 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 875328002797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328002800 Cytochrome P450; Region: p450; cl12078 875328002801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002802 short chain dehydrogenase; Provisional; Region: PRK07791 875328002803 NAD(P) binding site [chemical binding]; other site 875328002804 active site 875328002805 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 875328002806 metal ion-dependent adhesion site (MIDAS); other site 875328002807 MoxR-like ATPases [General function prediction only]; Region: COG0714 875328002808 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 875328002809 Walker A motif; other site 875328002810 ATP binding site [chemical binding]; other site 875328002811 Walker B motif; other site 875328002812 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 875328002813 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 875328002814 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 875328002815 ligand binding site [chemical binding]; other site 875328002816 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 875328002817 short chain dehydrogenase; Provisional; Region: PRK06914 875328002818 NADP binding site [chemical binding]; other site 875328002819 active site 875328002820 steroid binding site; other site 875328002821 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 875328002822 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 875328002823 NAD binding site [chemical binding]; other site 875328002824 catalytic residues [active] 875328002825 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328002826 Cytochrome P450; Region: p450; cl12078 875328002827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328002828 NAD(P) binding site [chemical binding]; other site 875328002829 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328002830 active site 875328002831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328002832 Cytochrome P450; Region: p450; cl12078 875328002833 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 875328002834 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328002835 dimer interface [polypeptide binding]; other site 875328002836 active site 875328002837 enoyl-CoA hydratase; Provisional; Region: PRK08252 875328002838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002839 substrate binding site [chemical binding]; other site 875328002840 oxyanion hole (OAH) forming residues; other site 875328002841 trimer interface [polypeptide binding]; other site 875328002842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 875328002843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 875328002844 trimer interface [polypeptide binding]; other site 875328002845 putative metal binding site [ion binding]; other site 875328002846 CAAX protease self-immunity; Region: Abi; pfam02517 875328002847 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328002848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328002849 substrate binding site [chemical binding]; other site 875328002850 oxyanion hole (OAH) forming residues; other site 875328002851 trimer interface [polypeptide binding]; other site 875328002852 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328002853 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328002854 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 875328002855 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 875328002856 NAD binding site [chemical binding]; other site 875328002857 homodimer interface [polypeptide binding]; other site 875328002858 homotetramer interface [polypeptide binding]; other site 875328002859 active site 875328002860 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 875328002861 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328002862 FMN binding site [chemical binding]; other site 875328002863 substrate binding site [chemical binding]; other site 875328002864 putative catalytic residue [active] 875328002865 Fic/DOC family; Region: Fic; cl00960 875328002866 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 875328002867 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 875328002868 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 875328002869 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 875328002870 active site 875328002871 metal binding site [ion binding]; metal-binding site 875328002872 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 875328002873 putative active site [active] 875328002874 putative metal binding site [ion binding]; other site 875328002875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002876 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 875328002877 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328002878 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328002879 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 875328002880 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 875328002881 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 875328002882 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 875328002883 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 875328002884 active site 875328002885 Fe binding site [ion binding]; other site 875328002886 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328002887 Methyltransferase domain; Region: Methyltransf_23; pfam13489 875328002888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328002889 S-adenosylmethionine binding site [chemical binding]; other site 875328002890 NAD-dependent deacetylase; Provisional; Region: PRK00481 875328002891 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 875328002892 NAD+ binding site [chemical binding]; other site 875328002893 substrate binding site [chemical binding]; other site 875328002894 Zn binding site [ion binding]; other site 875328002895 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328002896 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 875328002897 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 875328002898 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 875328002899 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 875328002900 minor groove reading motif; other site 875328002901 helix-hairpin-helix signature motif; other site 875328002902 mannosyltransferase; Provisional; Region: pimE; PRK13375 875328002903 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 875328002904 aromatic arch; other site 875328002905 DCoH dimer interaction site [polypeptide binding]; other site 875328002906 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 875328002907 DCoH tetramer interaction site [polypeptide binding]; other site 875328002908 substrate binding site [chemical binding]; other site 875328002909 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 875328002910 active site 875328002911 8-oxo-dGMP binding site [chemical binding]; other site 875328002912 nudix motif; other site 875328002913 metal binding site [ion binding]; metal-binding site 875328002914 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 875328002915 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 875328002916 [4Fe-4S] binding site [ion binding]; other site 875328002917 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328002918 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328002919 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328002920 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 875328002921 molybdopterin cofactor binding site; other site 875328002922 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 875328002923 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 875328002924 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 875328002925 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 875328002926 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328002927 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 875328002928 homotrimer interaction site [polypeptide binding]; other site 875328002929 putative active site [active] 875328002930 MarR family; Region: MarR_2; pfam12802 875328002931 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 875328002932 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 875328002933 G1 box; other site 875328002934 putative GEF interaction site [polypeptide binding]; other site 875328002935 GTP/Mg2+ binding site [chemical binding]; other site 875328002936 Switch I region; other site 875328002937 G2 box; other site 875328002938 G3 box; other site 875328002939 Switch II region; other site 875328002940 G4 box; other site 875328002941 G5 box; other site 875328002942 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 875328002943 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 875328002944 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 875328002945 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 875328002946 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 875328002947 FO synthase; Reviewed; Region: fbiC; PRK09234 875328002948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328002949 FeS/SAM binding site; other site 875328002950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328002951 FeS/SAM binding site; other site 875328002952 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 875328002953 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 875328002954 active site 875328002955 FMN binding site [chemical binding]; other site 875328002956 2,4-decadienoyl-CoA binding site; other site 875328002957 catalytic residue [active] 875328002958 4Fe-4S cluster binding site [ion binding]; other site 875328002959 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 875328002960 Predicted transcriptional regulators [Transcription]; Region: COG1695 875328002961 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 875328002962 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 875328002963 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 875328002964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328002966 homodimer interface [polypeptide binding]; other site 875328002967 catalytic residue [active] 875328002968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002969 PPE family; Region: PPE; pfam00823 875328002970 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328002971 PE family; Region: PE; pfam00934 875328002972 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328002973 PPE family; Region: PPE; pfam00823 875328002974 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 875328002975 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 875328002976 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 875328002977 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 875328002978 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 875328002979 D-pathway; other site 875328002980 Putative ubiquinol binding site [chemical binding]; other site 875328002981 Low-spin heme (heme b) binding site [chemical binding]; other site 875328002982 Putative water exit pathway; other site 875328002983 Binuclear center (heme o3/CuB) [ion binding]; other site 875328002984 K-pathway; other site 875328002985 Putative proton exit pathway; other site 875328002986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 875328002987 Predicted transcriptional regulator [Transcription]; Region: COG2345 875328002988 acyl-CoA synthetase; Validated; Region: PRK07787 875328002989 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328002990 acyl-activating enzyme (AAE) consensus motif; other site 875328002991 AMP binding site [chemical binding]; other site 875328002992 active site 875328002993 CoA binding site [chemical binding]; other site 875328002994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328002995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328002996 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328002997 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328002998 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 875328002999 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 875328003000 putative trimer interface [polypeptide binding]; other site 875328003001 putative CoA binding site [chemical binding]; other site 875328003002 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 875328003003 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 875328003004 metal binding site [ion binding]; metal-binding site 875328003005 putative dimer interface [polypeptide binding]; other site 875328003006 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 875328003007 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 875328003008 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 875328003009 acyl-activating enzyme (AAE) consensus motif; other site 875328003010 putative AMP binding site [chemical binding]; other site 875328003011 putative active site [active] 875328003012 putative CoA binding site [chemical binding]; other site 875328003013 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 875328003014 dihydropteroate synthase; Region: DHPS; TIGR01496 875328003015 substrate binding pocket [chemical binding]; other site 875328003016 dimer interface [polypeptide binding]; other site 875328003017 inhibitor binding site; inhibition site 875328003018 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 875328003019 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 875328003020 DivIVA domain; Region: DivI1A_domain; TIGR03544 875328003021 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 875328003022 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 875328003023 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 875328003024 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328003025 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 875328003026 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 875328003027 ligand binding site; other site 875328003028 oligomer interface; other site 875328003029 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 875328003030 dimer interface [polypeptide binding]; other site 875328003031 N-terminal domain interface [polypeptide binding]; other site 875328003032 sulfate 1 binding site; other site 875328003033 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 875328003034 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 875328003035 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 875328003036 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 875328003037 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 875328003038 Walker A/P-loop; other site 875328003039 ATP binding site [chemical binding]; other site 875328003040 Q-loop/lid; other site 875328003041 ABC transporter signature motif; other site 875328003042 Walker B; other site 875328003043 D-loop; other site 875328003044 H-loop/switch region; other site 875328003045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328003046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003047 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 875328003048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328003049 S-adenosylmethionine binding site [chemical binding]; other site 875328003050 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 875328003051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328003052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328003053 DNA binding residues [nucleotide binding] 875328003054 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 875328003055 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 875328003056 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 875328003057 protein binding site [polypeptide binding]; other site 875328003058 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 875328003059 Domain of unknown function DUF59; Region: DUF59; cl00941 875328003060 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 875328003061 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 875328003062 Walker A motif; other site 875328003063 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 875328003064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 875328003065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 875328003066 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 875328003067 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 875328003068 MgtE intracellular N domain; Region: MgtE_N; smart00924 875328003069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 875328003070 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 875328003071 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 875328003072 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 875328003073 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 875328003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003075 dimer interface [polypeptide binding]; other site 875328003076 conserved gate region; other site 875328003077 putative PBP binding loops; other site 875328003078 ABC-ATPase subunit interface; other site 875328003079 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 875328003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003081 dimer interface [polypeptide binding]; other site 875328003082 conserved gate region; other site 875328003083 ABC-ATPase subunit interface; other site 875328003084 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 875328003085 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 875328003086 Walker A/P-loop; other site 875328003087 ATP binding site [chemical binding]; other site 875328003088 Q-loop/lid; other site 875328003089 ABC transporter signature motif; other site 875328003090 Walker B; other site 875328003091 D-loop; other site 875328003092 H-loop/switch region; other site 875328003093 TOBE domain; Region: TOBE_2; pfam08402 875328003094 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 875328003095 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 875328003096 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 875328003097 oligomer interface [polypeptide binding]; other site 875328003098 metal binding site [ion binding]; metal-binding site 875328003099 metal binding site [ion binding]; metal-binding site 875328003100 putative Cl binding site [ion binding]; other site 875328003101 basic sphincter; other site 875328003102 hydrophobic gate; other site 875328003103 periplasmic entrance; other site 875328003104 malate dehydrogenase; Provisional; Region: PRK05442 875328003105 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 875328003106 NAD(P) binding site [chemical binding]; other site 875328003107 dimer interface [polypeptide binding]; other site 875328003108 malate binding site [chemical binding]; other site 875328003109 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 875328003110 Malic enzyme, N-terminal domain; Region: malic; pfam00390 875328003111 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 875328003112 putative NAD(P) binding site [chemical binding]; other site 875328003113 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 875328003114 short chain dehydrogenase; Provisional; Region: PRK06181 875328003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328003116 NAD(P) binding site [chemical binding]; other site 875328003117 active site 875328003118 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 875328003119 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 875328003120 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 875328003121 TPP-binding site [chemical binding]; other site 875328003122 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 875328003123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 875328003124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328003125 putative substrate translocation pore; other site 875328003126 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 875328003127 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 875328003128 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 875328003129 ATP binding site [chemical binding]; other site 875328003130 Mg++ binding site [ion binding]; other site 875328003131 motif III; other site 875328003132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328003133 nucleotide binding region [chemical binding]; other site 875328003134 ATP-binding site [chemical binding]; other site 875328003135 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 875328003136 putative RNA binding site [nucleotide binding]; other site 875328003137 Acyltransferase family; Region: Acyl_transf_3; pfam01757 875328003138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328003139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003140 Ras GTPase Activating Domain; Region: RasGAP; cl02569 875328003141 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328003142 Cytochrome P450; Region: p450; cl12078 875328003143 FAD binding domain; Region: FAD_binding_4; pfam01565 875328003144 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 875328003145 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 875328003146 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 875328003147 Fe-S cluster binding site [ion binding]; other site 875328003148 DNA binding site [nucleotide binding] 875328003149 active site 875328003150 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 875328003151 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328003152 Domain of unknown function (DUF385); Region: DUF385; pfam04075 875328003153 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 875328003154 HIT family signature motif; other site 875328003155 catalytic residue [active] 875328003156 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 875328003157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328003159 homodimer interface [polypeptide binding]; other site 875328003160 catalytic residue [active] 875328003161 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328003162 cyclase homology domain; Region: CHD; cd07302 875328003163 nucleotidyl binding site; other site 875328003164 metal binding site [ion binding]; metal-binding site 875328003165 dimer interface [polypeptide binding]; other site 875328003166 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 875328003167 dimer interface [polypeptide binding]; other site 875328003168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 875328003169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 875328003170 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 875328003171 Walker A/P-loop; other site 875328003172 ATP binding site [chemical binding]; other site 875328003173 Q-loop/lid; other site 875328003174 ABC transporter signature motif; other site 875328003175 Walker B; other site 875328003176 D-loop; other site 875328003177 H-loop/switch region; other site 875328003178 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 875328003179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 875328003180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328003181 Walker A/P-loop; other site 875328003182 ATP binding site [chemical binding]; other site 875328003183 Q-loop/lid; other site 875328003184 ABC transporter signature motif; other site 875328003185 Walker B; other site 875328003186 D-loop; other site 875328003187 H-loop/switch region; other site 875328003188 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 875328003189 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 875328003190 MarR family; Region: MarR_2; cl17246 875328003191 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328003192 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 875328003193 MarR family; Region: MarR_2; cl17246 875328003194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328003195 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 875328003196 acyl-CoA synthetase; Validated; Region: PRK05850 875328003197 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328003198 acyl-activating enzyme (AAE) consensus motif; other site 875328003199 active site 875328003200 MarR family; Region: MarR_2; pfam12802 875328003201 TetR family transcriptional regulator; Provisional; Region: PRK14996 875328003202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003203 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 875328003204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328003205 active site 875328003206 PemK-like protein; Region: PemK; pfam02452 875328003207 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 875328003208 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 875328003209 Excalibur calcium-binding domain; Region: Excalibur; smart00894 875328003210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328003211 non-specific DNA binding site [nucleotide binding]; other site 875328003212 salt bridge; other site 875328003213 sequence-specific DNA binding site [nucleotide binding]; other site 875328003214 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 875328003215 TIGR02677 family protein; Region: TIGR02677 875328003216 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 875328003217 TIGR02680 family protein; Region: TIGR02680 875328003218 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 875328003219 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 875328003220 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 875328003221 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 875328003222 putative active site [active] 875328003223 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328003224 catalytic core [active] 875328003225 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 875328003226 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 875328003227 active site 875328003228 metal binding site [ion binding]; metal-binding site 875328003229 DNA binding site [nucleotide binding] 875328003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328003231 Walker A/P-loop; other site 875328003232 ATP binding site [chemical binding]; other site 875328003233 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 875328003234 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 875328003235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 875328003236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 875328003237 Walker A/P-loop; other site 875328003238 ATP binding site [chemical binding]; other site 875328003239 Q-loop/lid; other site 875328003240 ABC transporter signature motif; other site 875328003241 Walker B; other site 875328003242 D-loop; other site 875328003243 H-loop/switch region; other site 875328003244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 875328003245 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 875328003246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 875328003247 Walker A/P-loop; other site 875328003248 ATP binding site [chemical binding]; other site 875328003249 Q-loop/lid; other site 875328003250 ABC transporter signature motif; other site 875328003251 Walker B; other site 875328003252 D-loop; other site 875328003253 H-loop/switch region; other site 875328003254 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 875328003255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 875328003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003257 dimer interface [polypeptide binding]; other site 875328003258 conserved gate region; other site 875328003259 putative PBP binding loops; other site 875328003260 ABC-ATPase subunit interface; other site 875328003261 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 875328003262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003263 dimer interface [polypeptide binding]; other site 875328003264 conserved gate region; other site 875328003265 putative PBP binding loops; other site 875328003266 ABC-ATPase subunit interface; other site 875328003267 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 875328003268 active site clefts [active] 875328003269 zinc binding site [ion binding]; other site 875328003270 dimer interface [polypeptide binding]; other site 875328003271 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 875328003272 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 875328003273 Active Sites [active] 875328003274 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 875328003275 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 875328003276 CysD dimerization site [polypeptide binding]; other site 875328003277 G1 box; other site 875328003278 putative GEF interaction site [polypeptide binding]; other site 875328003279 GTP/Mg2+ binding site [chemical binding]; other site 875328003280 Switch I region; other site 875328003281 G2 box; other site 875328003282 G3 box; other site 875328003283 Switch II region; other site 875328003284 G4 box; other site 875328003285 G5 box; other site 875328003286 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 875328003287 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 875328003288 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 875328003289 ligand-binding site [chemical binding]; other site 875328003290 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 875328003291 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 875328003292 active site 875328003293 Rrf2 family protein; Region: rrf2_super; TIGR00738 875328003294 Transcriptional regulator; Region: Rrf2; pfam02082 875328003295 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 875328003296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328003297 metal binding site [ion binding]; metal-binding site 875328003298 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 875328003299 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328003300 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 875328003301 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328003302 PPE family; Region: PPE; pfam00823 875328003303 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328003304 PPE family; Region: PPE; pfam00823 875328003305 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328003306 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 875328003307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328003308 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328003309 Emopamil binding protein; Region: EBP; pfam05241 875328003310 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 875328003311 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 875328003312 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 875328003313 active site 875328003314 HIGH motif; other site 875328003315 KMSK motif region; other site 875328003316 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 875328003317 tRNA binding surface [nucleotide binding]; other site 875328003318 anticodon binding site; other site 875328003319 diaminopimelate decarboxylase; Region: lysA; TIGR01048 875328003320 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 875328003321 active site 875328003322 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 875328003323 substrate binding site [chemical binding]; other site 875328003324 catalytic residues [active] 875328003325 dimer interface [polypeptide binding]; other site 875328003326 homoserine dehydrogenase; Provisional; Region: PRK06349 875328003327 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 875328003328 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 875328003329 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 875328003330 threonine synthase; Reviewed; Region: PRK06721 875328003331 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 875328003332 homodimer interface [polypeptide binding]; other site 875328003333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328003334 catalytic residue [active] 875328003335 homoserine kinase; Provisional; Region: PRK01212 875328003336 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 875328003337 transcription termination factor Rho; Provisional; Region: PRK12608 875328003338 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 875328003339 RNA binding site [nucleotide binding]; other site 875328003340 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 875328003341 multimer interface [polypeptide binding]; other site 875328003342 Walker A motif; other site 875328003343 ATP binding site [chemical binding]; other site 875328003344 Walker B motif; other site 875328003345 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 875328003346 peptide chain release factor 1; Validated; Region: prfA; PRK00591 875328003347 PCRF domain; Region: PCRF; pfam03462 875328003348 RF-1 domain; Region: RF-1; pfam00472 875328003349 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 875328003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328003351 S-adenosylmethionine binding site [chemical binding]; other site 875328003352 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 875328003353 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 875328003354 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 875328003355 Mg++ binding site [ion binding]; other site 875328003356 putative catalytic motif [active] 875328003357 substrate binding site [chemical binding]; other site 875328003358 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 875328003359 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 875328003360 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 875328003361 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 875328003362 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 875328003363 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 875328003364 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 875328003365 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 875328003366 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 875328003367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 875328003368 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 875328003369 beta subunit interaction interface [polypeptide binding]; other site 875328003370 Walker A motif; other site 875328003371 ATP binding site [chemical binding]; other site 875328003372 Walker B motif; other site 875328003373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 875328003374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 875328003375 core domain interface [polypeptide binding]; other site 875328003376 delta subunit interface [polypeptide binding]; other site 875328003377 epsilon subunit interface [polypeptide binding]; other site 875328003378 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 875328003379 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 875328003380 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 875328003381 alpha subunit interaction interface [polypeptide binding]; other site 875328003382 Walker A motif; other site 875328003383 ATP binding site [chemical binding]; other site 875328003384 Walker B motif; other site 875328003385 inhibitor binding site; inhibition site 875328003386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 875328003387 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 875328003388 gamma subunit interface [polypeptide binding]; other site 875328003389 epsilon subunit interface [polypeptide binding]; other site 875328003390 LBP interface [polypeptide binding]; other site 875328003391 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 875328003392 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 875328003393 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 875328003394 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 875328003395 hinge; other site 875328003396 active site 875328003397 PE-PPE domain; Region: PE-PPE; pfam08237 875328003398 Transposase; Region: HTH_Tnp_1; pfam01527 875328003399 putative transposase OrfB; Reviewed; Region: PHA02517 875328003400 HTH-like domain; Region: HTH_21; pfam13276 875328003401 Integrase core domain; Region: rve; pfam00665 875328003402 Integrase core domain; Region: rve_3; pfam13683 875328003403 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 875328003404 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 875328003405 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 875328003406 DNA binding site [nucleotide binding] 875328003407 active site 875328003408 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 875328003409 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 875328003410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328003411 AlkA N-terminal domain; Region: AlkA_N; pfam06029 875328003412 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 875328003413 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 875328003414 minor groove reading motif; other site 875328003415 helix-hairpin-helix signature motif; other site 875328003416 substrate binding pocket [chemical binding]; other site 875328003417 active site 875328003418 glutaminase; Provisional; Region: PRK00971 875328003419 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 875328003420 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 875328003421 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328003422 cyclase homology domain; Region: CHD; cd07302 875328003423 nucleotidyl binding site; other site 875328003424 metal binding site [ion binding]; metal-binding site 875328003425 dimer interface [polypeptide binding]; other site 875328003426 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 875328003427 hypothetical protein; Provisional; Region: PRK03298 875328003428 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 875328003429 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 875328003430 putative active site [active] 875328003431 putative FMN binding site [chemical binding]; other site 875328003432 putative substrate binding site [chemical binding]; other site 875328003433 putative catalytic residue [active] 875328003434 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 875328003435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328003436 dimer interface [polypeptide binding]; other site 875328003437 substrate binding site [chemical binding]; other site 875328003438 metal binding site [ion binding]; metal-binding site 875328003439 putative acyltransferase; Provisional; Region: PRK05790 875328003440 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328003441 dimer interface [polypeptide binding]; other site 875328003442 active site 875328003443 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 875328003444 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 875328003445 glycogen branching enzyme; Provisional; Region: PRK05402 875328003446 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 875328003447 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 875328003448 active site 875328003449 catalytic site [active] 875328003450 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 875328003451 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 875328003452 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 875328003453 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 875328003454 active site 875328003455 homodimer interface [polypeptide binding]; other site 875328003456 catalytic site [active] 875328003457 acceptor binding site [chemical binding]; other site 875328003458 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 875328003459 putative homodimer interface [polypeptide binding]; other site 875328003460 putative active site pocket [active] 875328003461 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 875328003462 Predicted metalloprotease [General function prediction only]; Region: COG2321 875328003463 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 875328003464 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 875328003465 DEAD/DEAH box helicase; Region: DEAD; pfam00270 875328003466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 875328003467 putative Mg++ binding site [ion binding]; other site 875328003468 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 875328003469 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 875328003470 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 875328003471 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 875328003472 active site 875328003473 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 875328003474 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 875328003475 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 875328003476 putative active site pocket [active] 875328003477 cleavage site 875328003478 Rhomboid family; Region: Rhomboid; cl11446 875328003479 glutamate racemase; Provisional; Region: PRK00865 875328003480 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 875328003481 ribonuclease PH; Reviewed; Region: rph; PRK00173 875328003482 Ribonuclease PH; Region: RNase_PH_bact; cd11362 875328003483 hexamer interface [polypeptide binding]; other site 875328003484 active site 875328003485 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 875328003486 active site 875328003487 dimerization interface [polypeptide binding]; other site 875328003488 Protein kinase domain; Region: Pkinase; pfam00069 875328003489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328003490 active site 875328003491 ATP binding site [chemical binding]; other site 875328003492 substrate binding site [chemical binding]; other site 875328003493 activation loop (A-loop); other site 875328003494 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 875328003495 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 875328003496 Glucitol operon activator protein (GutM); Region: GutM; cl01890 875328003497 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 875328003498 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 875328003499 active site 875328003500 DNA binding site [nucleotide binding] 875328003501 Int/Topo IB signature motif; other site 875328003502 ATP phosphoribosyltransferase; Region: HisG; cl15266 875328003503 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 875328003504 polymerase nucleotide-binding site; other site 875328003505 DNA-binding residues [nucleotide binding]; DNA binding site 875328003506 nucleotide binding site [chemical binding]; other site 875328003507 primase nucleotide-binding site [nucleotide binding]; other site 875328003508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328003509 non-specific DNA binding site [nucleotide binding]; other site 875328003510 salt bridge; other site 875328003511 sequence-specific DNA binding site [nucleotide binding]; other site 875328003512 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328003513 active site 875328003514 Uncharacterized conserved protein [Function unknown]; Region: COG4127 875328003515 Restriction endonuclease; Region: Mrr_cat; pfam04471 875328003516 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 875328003517 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 875328003518 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 875328003519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328003520 ATP binding site [chemical binding]; other site 875328003521 putative Mg++ binding site [ion binding]; other site 875328003522 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 875328003523 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 875328003524 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 875328003525 HsdM N-terminal domain; Region: HsdM_N; pfam12161 875328003526 Methyltransferase domain; Region: Methyltransf_26; pfam13659 875328003527 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328003528 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 875328003529 active site 875328003530 Fe-S cluster binding site [ion binding]; other site 875328003531 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 875328003532 DNA-binding interface [nucleotide binding]; DNA binding site 875328003533 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 875328003534 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 875328003535 catalytic residues [active] 875328003536 catalytic nucleophile [active] 875328003537 Presynaptic Site I dimer interface [polypeptide binding]; other site 875328003538 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 875328003539 Synaptic Flat tetramer interface [polypeptide binding]; other site 875328003540 Synaptic Site I dimer interface [polypeptide binding]; other site 875328003541 DNA binding site [nucleotide binding] 875328003542 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 875328003543 DNA-binding interface [nucleotide binding]; DNA binding site 875328003544 putative transposase OrfB; Reviewed; Region: PHA02517 875328003545 HTH-like domain; Region: HTH_21; pfam13276 875328003546 Integrase core domain; Region: rve; pfam00665 875328003547 Integrase core domain; Region: rve_3; pfam13683 875328003548 Transposase; Region: HTH_Tnp_1; pfam01527 875328003549 RES domain; Region: RES; pfam08808 875328003550 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328003551 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328003552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328003553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 875328003554 putative substrate translocation pore; other site 875328003555 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 875328003556 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 875328003557 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 875328003558 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 875328003559 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328003560 phosphate binding site [ion binding]; other site 875328003561 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 875328003562 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328003563 active site 2 [active] 875328003564 active site 1 [active] 875328003565 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 875328003566 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 875328003567 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 875328003568 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 875328003569 putative NAD(P) binding site [chemical binding]; other site 875328003570 active site 875328003571 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 875328003572 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 875328003573 active site 875328003574 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 875328003575 hypothetical protein; Provisional; Region: PRK07907 875328003576 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 875328003577 active site 875328003578 metal binding site [ion binding]; metal-binding site 875328003579 dimer interface [polypeptide binding]; other site 875328003580 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 875328003581 dimer interface [polypeptide binding]; other site 875328003582 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 875328003583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328003584 catalytic triad [active] 875328003585 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 875328003586 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 875328003587 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 875328003588 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 875328003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 875328003590 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 875328003591 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 875328003592 catalytic site [active] 875328003593 putative active site [active] 875328003594 putative substrate binding site [chemical binding]; other site 875328003595 dimer interface [polypeptide binding]; other site 875328003596 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 875328003597 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 875328003598 classical (c) SDRs; Region: SDR_c; cd05233 875328003599 NAD(P) binding site [chemical binding]; other site 875328003600 active site 875328003601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328003602 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 875328003603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328003604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328003606 AMP-binding domain protein; Validated; Region: PRK08315 875328003607 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328003608 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 875328003609 acyl-activating enzyme (AAE) consensus motif; other site 875328003610 putative AMP binding site [chemical binding]; other site 875328003611 putative active site [active] 875328003612 putative CoA binding site [chemical binding]; other site 875328003613 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 875328003614 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 875328003615 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 875328003616 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328003617 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328003618 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 875328003619 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328003620 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 875328003621 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 875328003622 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328003623 carboxyltransferase (CT) interaction site; other site 875328003624 biotinylation site [posttranslational modification]; other site 875328003625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328003626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328003627 active site 875328003628 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 875328003629 putative active site [active] 875328003630 putative catalytic site [active] 875328003631 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 875328003632 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 875328003633 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 875328003634 metal binding site [ion binding]; metal-binding site 875328003635 substrate binding pocket [chemical binding]; other site 875328003636 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 875328003637 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 875328003638 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 875328003639 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328003640 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 875328003641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328003642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003643 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 875328003644 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 875328003645 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 875328003646 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 875328003647 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 875328003648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328003649 DNA-binding site [nucleotide binding]; DNA binding site 875328003650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328003651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328003652 catalytic residue [active] 875328003653 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 875328003654 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 875328003655 tetramer interface [polypeptide binding]; other site 875328003656 TPP-binding site [chemical binding]; other site 875328003657 heterodimer interface [polypeptide binding]; other site 875328003658 phosphorylation loop region [posttranslational modification] 875328003659 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 875328003660 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 875328003661 alpha subunit interface [polypeptide binding]; other site 875328003662 TPP binding site [chemical binding]; other site 875328003663 heterodimer interface [polypeptide binding]; other site 875328003664 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 875328003665 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 875328003666 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 875328003667 E3 interaction surface; other site 875328003668 lipoyl attachment site [posttranslational modification]; other site 875328003669 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 875328003670 enoyl-CoA hydratase; Provisional; Region: PRK05870 875328003671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328003672 substrate binding site [chemical binding]; other site 875328003673 oxyanion hole (OAH) forming residues; other site 875328003674 trimer interface [polypeptide binding]; other site 875328003675 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328003676 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328003677 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 875328003678 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 875328003679 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328003680 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328003681 putative acyl-acceptor binding pocket; other site 875328003682 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 875328003683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 875328003684 putative acyl-acceptor binding pocket; other site 875328003685 Copper resistance protein D; Region: CopD; pfam05425 875328003686 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 875328003687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328003688 metabolite-proton symporter; Region: 2A0106; TIGR00883 875328003689 putative substrate translocation pore; other site 875328003690 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 875328003691 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 875328003692 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 875328003693 dimer interface [polypeptide binding]; other site 875328003694 ssDNA binding site [nucleotide binding]; other site 875328003695 tetramer (dimer of dimers) interface [polypeptide binding]; other site 875328003696 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 875328003697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328003698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328003699 ABC transporter; Region: ABC_tran_2; pfam12848 875328003700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328003701 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 875328003702 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 875328003703 active site 875328003704 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 875328003705 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 875328003706 active site 875328003707 catalytic site [active] 875328003708 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 875328003709 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 875328003710 apolar tunnel; other site 875328003711 heme binding site [chemical binding]; other site 875328003712 dimerization interface [polypeptide binding]; other site 875328003713 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 875328003714 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328003715 active site 875328003716 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 875328003717 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 875328003718 active site 875328003719 catalytic triad [active] 875328003720 dimer interface [polypeptide binding]; other site 875328003721 Repair protein; Region: Repair_PSII; cl01535 875328003722 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 875328003723 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 875328003724 Zn binding site [ion binding]; other site 875328003725 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 875328003726 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 875328003727 catalytic residues [active] 875328003728 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 875328003729 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 875328003730 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 875328003731 putative DNA binding site [nucleotide binding]; other site 875328003732 catalytic residue [active] 875328003733 putative H2TH interface [polypeptide binding]; other site 875328003734 putative catalytic residues [active] 875328003735 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 875328003736 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 875328003737 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328003738 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328003739 trigger factor; Provisional; Region: tig; PRK01490 875328003740 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 875328003741 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 875328003742 Clp protease; Region: CLP_protease; pfam00574 875328003743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 875328003744 oligomer interface [polypeptide binding]; other site 875328003745 active site residues [active] 875328003746 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 875328003747 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 875328003748 oligomer interface [polypeptide binding]; other site 875328003749 active site residues [active] 875328003750 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 875328003751 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 875328003752 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 875328003753 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 875328003754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328003755 Walker A motif; other site 875328003756 ATP binding site [chemical binding]; other site 875328003757 Walker B motif; other site 875328003758 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 875328003759 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 875328003760 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 875328003761 putative di-iron ligands [ion binding]; other site 875328003762 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 875328003763 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 875328003764 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 875328003765 dimer interface [polypeptide binding]; other site 875328003766 PYR/PP interface [polypeptide binding]; other site 875328003767 TPP binding site [chemical binding]; other site 875328003768 substrate binding site [chemical binding]; other site 875328003769 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 875328003770 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 875328003771 TPP-binding site [chemical binding]; other site 875328003772 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 875328003773 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 875328003774 GTP binding site; other site 875328003775 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 875328003776 Uncharacterized conserved protein [Function unknown]; Region: COG3268 875328003777 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 875328003778 NAD(P) binding pocket [chemical binding]; other site 875328003779 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 875328003780 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 875328003781 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328003782 active site 875328003783 HIGH motif; other site 875328003784 nucleotide binding site [chemical binding]; other site 875328003785 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 875328003786 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 875328003787 active site 875328003788 KMSKS motif; other site 875328003789 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 875328003790 tRNA binding surface [nucleotide binding]; other site 875328003791 anticodon binding site; other site 875328003792 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 875328003793 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 875328003794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 875328003795 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 875328003796 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 875328003797 active site 875328003798 multimer interface [polypeptide binding]; other site 875328003799 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 875328003800 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 875328003801 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 875328003802 homodimer interface [polypeptide binding]; other site 875328003803 oligonucleotide binding site [chemical binding]; other site 875328003804 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 875328003805 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 875328003806 GTPase CgtA; Reviewed; Region: obgE; PRK12296 875328003807 GTP1/OBG; Region: GTP1_OBG; pfam01018 875328003808 Obg GTPase; Region: Obg; cd01898 875328003809 G1 box; other site 875328003810 GTP/Mg2+ binding site [chemical binding]; other site 875328003811 Switch I region; other site 875328003812 G2 box; other site 875328003813 G3 box; other site 875328003814 Switch II region; other site 875328003815 G4 box; other site 875328003816 G5 box; other site 875328003817 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 875328003818 gamma-glutamyl kinase; Provisional; Region: PRK05429 875328003819 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 875328003820 nucleotide binding site [chemical binding]; other site 875328003821 homotetrameric interface [polypeptide binding]; other site 875328003822 putative phosphate binding site [ion binding]; other site 875328003823 putative allosteric binding site; other site 875328003824 PUA domain; Region: PUA; pfam01472 875328003825 PE-PPE domain; Region: PE-PPE; pfam08237 875328003826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328003827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328003828 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328003829 Cytochrome P450; Region: p450; cl12078 875328003830 putative sialic acid transporter; Region: 2A0112; TIGR00891 875328003831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328003832 putative substrate translocation pore; other site 875328003833 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 875328003834 NAD-dependent deacetylase; Provisional; Region: PRK05333 875328003835 Isochorismatase family; Region: Isochorismatase; pfam00857 875328003836 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 875328003837 catalytic triad [active] 875328003838 conserved cis-peptide bond; other site 875328003839 NAD synthetase; Reviewed; Region: nadE; PRK02628 875328003840 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 875328003841 multimer interface [polypeptide binding]; other site 875328003842 active site 875328003843 catalytic triad [active] 875328003844 protein interface 1 [polypeptide binding]; other site 875328003845 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 875328003846 homodimer interface [polypeptide binding]; other site 875328003847 NAD binding pocket [chemical binding]; other site 875328003848 ATP binding pocket [chemical binding]; other site 875328003849 Mg binding site [ion binding]; other site 875328003850 active-site loop [active] 875328003851 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 875328003852 dimer interface [polypeptide binding]; other site 875328003853 hexamer interface [polypeptide binding]; other site 875328003854 active site 2 [active] 875328003855 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 875328003856 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 875328003857 substrate binding site [chemical binding]; other site 875328003858 ATP binding site [chemical binding]; other site 875328003859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328003860 dimerization interface [polypeptide binding]; other site 875328003861 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328003862 cyclase homology domain; Region: CHD; cd07302 875328003863 nucleotidyl binding site; other site 875328003864 metal binding site [ion binding]; metal-binding site 875328003865 dimer interface [polypeptide binding]; other site 875328003866 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 875328003867 Mechanosensitive ion channel; Region: MS_channel; pfam00924 875328003868 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 875328003869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 875328003870 ligand binding site [chemical binding]; other site 875328003871 flexible hinge region; other site 875328003872 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 875328003873 putative catalytic cysteine [active] 875328003874 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 875328003875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328003876 Walker A motif; other site 875328003877 ATP binding site [chemical binding]; other site 875328003878 Walker B motif; other site 875328003879 arginine finger; other site 875328003880 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 875328003881 AAA ATPase domain; Region: AAA_16; pfam13191 875328003882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328003883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328003884 DNA binding residues [nucleotide binding] 875328003885 dimerization interface [polypeptide binding]; other site 875328003886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328003887 S-adenosylmethionine binding site [chemical binding]; other site 875328003888 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 875328003889 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 875328003890 active site 875328003891 (T/H)XGH motif; other site 875328003892 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 875328003893 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328003894 catalytic core [active] 875328003895 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 875328003896 active site 875328003897 catalytic triad [active] 875328003898 oxyanion hole [active] 875328003899 EDD domain protein, DegV family; Region: DegV; TIGR00762 875328003900 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 875328003901 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328003902 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328003903 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328003904 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 875328003905 hypothetical protein; Provisional; Region: PRK01346 875328003906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328003907 Coenzyme A binding pocket [chemical binding]; other site 875328003908 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 875328003909 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328003910 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328003911 active site 875328003912 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 875328003913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328003914 active site 875328003915 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 875328003916 Helix-hairpin-helix motif; Region: HHH; pfam00633 875328003917 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 875328003918 Competence protein; Region: Competence; pfam03772 875328003919 hypothetical protein; Reviewed; Region: PRK07914 875328003920 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 875328003921 ribonuclease Z; Reviewed; Region: PRK00055 875328003922 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 875328003923 FOG: CBS domain [General function prediction only]; Region: COG0517 875328003924 PemK-like protein; Region: PemK; pfam02452 875328003925 GTP-binding protein LepA; Provisional; Region: PRK05433 875328003926 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 875328003927 putative GEF interaction site [polypeptide binding]; other site 875328003928 Switch I region; other site 875328003929 G2 box; other site 875328003930 G3 box; other site 875328003931 Switch II region; other site 875328003932 GTP/Mg2+ binding site [chemical binding]; other site 875328003933 G4 box; other site 875328003934 G5 box; other site 875328003935 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 875328003936 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 875328003937 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 875328003938 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328003939 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 875328003940 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 875328003941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 875328003942 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 875328003943 sulfate transport protein; Provisional; Region: cysT; CHL00187 875328003944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003945 dimer interface [polypeptide binding]; other site 875328003946 conserved gate region; other site 875328003947 putative PBP binding loops; other site 875328003948 ABC-ATPase subunit interface; other site 875328003949 sulfate transport protein; Provisional; Region: cysT; CHL00187 875328003950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328003951 dimer interface [polypeptide binding]; other site 875328003952 conserved gate region; other site 875328003953 putative PBP binding loops; other site 875328003954 ABC-ATPase subunit interface; other site 875328003955 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 875328003956 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 875328003957 Walker A/P-loop; other site 875328003958 ATP binding site [chemical binding]; other site 875328003959 Q-loop/lid; other site 875328003960 ABC transporter signature motif; other site 875328003961 Walker B; other site 875328003962 D-loop; other site 875328003963 H-loop/switch region; other site 875328003964 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 875328003965 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 875328003966 putative active site [active] 875328003967 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 875328003968 putative active site [active] 875328003969 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 875328003970 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 875328003971 Active Sites [active] 875328003972 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 875328003973 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 875328003974 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 875328003975 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 875328003976 coproporphyrinogen III oxidase; Validated; Region: PRK05628 875328003977 HemN C-terminal domain; Region: HemN_C; pfam06969 875328003978 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 875328003979 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 875328003980 iron-sulfur cluster [ion binding]; other site 875328003981 [2Fe-2S] cluster binding site [ion binding]; other site 875328003982 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 875328003983 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 875328003984 putative homotetramer interface [polypeptide binding]; other site 875328003985 putative homodimer interface [polypeptide binding]; other site 875328003986 putative allosteric switch controlling residues; other site 875328003987 putative metal binding site [ion binding]; other site 875328003988 putative homodimer-homodimer interface [polypeptide binding]; other site 875328003989 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 875328003990 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328003991 active site 875328003992 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328003993 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 875328003994 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 875328003995 KR domain; Region: KR; pfam08659 875328003996 NADP binding site [chemical binding]; other site 875328003997 active site 875328003998 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328003999 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 875328004000 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 875328004001 acyl-activating enzyme (AAE) consensus motif; other site 875328004002 active site 875328004003 AMP binding site [chemical binding]; other site 875328004004 substrate binding site [chemical binding]; other site 875328004005 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 875328004006 Condensation domain; Region: Condensation; pfam00668 875328004007 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 875328004008 Nonribosomal peptide synthase; Region: NRPS; pfam08415 875328004009 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 875328004010 acyl-activating enzyme (AAE) consensus motif; other site 875328004011 AMP binding site [chemical binding]; other site 875328004012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328004013 acyl carrier protein; Validated; Region: PRK05883 875328004014 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 875328004015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328004016 acyl-activating enzyme (AAE) consensus motif; other site 875328004017 AMP binding site [chemical binding]; other site 875328004018 active site 875328004019 CoA binding site [chemical binding]; other site 875328004020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328004021 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328004022 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328004023 active site 875328004024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 875328004025 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 875328004026 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 875328004027 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 875328004028 FAD binding pocket [chemical binding]; other site 875328004029 FAD binding motif [chemical binding]; other site 875328004030 phosphate binding motif [ion binding]; other site 875328004031 NAD binding pocket [chemical binding]; other site 875328004032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328004033 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 875328004034 Walker A/P-loop; other site 875328004035 ATP binding site [chemical binding]; other site 875328004036 Q-loop/lid; other site 875328004037 ABC transporter signature motif; other site 875328004038 Walker B; other site 875328004039 D-loop; other site 875328004040 H-loop/switch region; other site 875328004041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 875328004042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328004043 Walker A/P-loop; other site 875328004044 ATP binding site [chemical binding]; other site 875328004045 Q-loop/lid; other site 875328004046 ABC transporter signature motif; other site 875328004047 Walker B; other site 875328004048 D-loop; other site 875328004049 H-loop/switch region; other site 875328004050 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 875328004051 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328004052 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 875328004053 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328004054 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 875328004055 active site 875328004056 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 875328004057 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328004058 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 875328004059 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 875328004060 NADP binding site [chemical binding]; other site 875328004061 active site 875328004062 Condensation domain; Region: Condensation; pfam00668 875328004063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 875328004064 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 875328004065 acyl-activating enzyme (AAE) consensus motif; other site 875328004066 AMP binding site [chemical binding]; other site 875328004067 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328004068 Condensation domain; Region: Condensation; pfam00668 875328004069 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 875328004070 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 875328004071 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 875328004072 acyl-activating enzyme (AAE) consensus motif; other site 875328004073 AMP binding site [chemical binding]; other site 875328004074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328004075 Condensation domain; Region: Condensation; pfam00668 875328004076 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 875328004077 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 875328004078 acyl-activating enzyme (AAE) consensus motif; other site 875328004079 AMP binding site [chemical binding]; other site 875328004080 Condensation domain; Region: Condensation; pfam00668 875328004081 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 875328004082 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 875328004083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328004084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 875328004085 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 875328004086 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 875328004087 N- and C-terminal domain interface [polypeptide binding]; other site 875328004088 active site 875328004089 MgATP binding site [chemical binding]; other site 875328004090 catalytic site [active] 875328004091 metal binding site [ion binding]; metal-binding site 875328004092 xylulose binding site [chemical binding]; other site 875328004093 putative homodimer interface [polypeptide binding]; other site 875328004094 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 875328004095 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 875328004096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328004097 catalytic residue [active] 875328004098 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 875328004099 HTH domain; Region: HTH_11; cl17392 875328004100 chaperone protein DnaJ; Provisional; Region: PRK14278 875328004101 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 875328004102 HSP70 interaction site [polypeptide binding]; other site 875328004103 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 875328004104 Zn binding sites [ion binding]; other site 875328004105 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 875328004106 dimer interface [polypeptide binding]; other site 875328004107 RNA methyltransferase, RsmE family; Region: TIGR00046 875328004108 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 875328004109 Helix-turn-helix domain; Region: HTH_18; pfam12833 875328004110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328004111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328004112 S-adenosylmethionine binding site [chemical binding]; other site 875328004113 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 875328004114 PhoH-like protein; Region: PhoH; pfam02562 875328004115 metal-binding heat shock protein; Provisional; Region: PRK00016 875328004116 Domain of unknown function DUF21; Region: DUF21; pfam01595 875328004117 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 875328004118 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 875328004119 Transporter associated domain; Region: CorC_HlyC; smart01091 875328004120 GTPase Era; Reviewed; Region: era; PRK00089 875328004121 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 875328004122 G1 box; other site 875328004123 GTP/Mg2+ binding site [chemical binding]; other site 875328004124 Switch I region; other site 875328004125 G2 box; other site 875328004126 Switch II region; other site 875328004127 G3 box; other site 875328004128 G4 box; other site 875328004129 G5 box; other site 875328004130 KH domain; Region: KH_2; pfam07650 875328004131 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328004132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328004133 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 875328004134 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 875328004135 active site residue [active] 875328004136 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 875328004137 active site residue [active] 875328004138 amidase; Provisional; Region: PRK06061 875328004139 Amidase; Region: Amidase; pfam01425 875328004140 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 875328004141 Recombination protein O N terminal; Region: RecO_N; pfam11967 875328004142 Recombination protein O C terminal; Region: RecO_C; pfam02565 875328004143 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328004144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328004145 S-adenosylmethionine binding site [chemical binding]; other site 875328004146 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 875328004147 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 875328004148 catalytic residue [active] 875328004149 putative FPP diphosphate binding site; other site 875328004150 putative FPP binding hydrophobic cleft; other site 875328004151 dimer interface [polypeptide binding]; other site 875328004152 putative IPP diphosphate binding site; other site 875328004153 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 875328004154 metal binding site 2 [ion binding]; metal-binding site 875328004155 putative DNA binding helix; other site 875328004156 metal binding site 1 [ion binding]; metal-binding site 875328004157 dimer interface [polypeptide binding]; other site 875328004158 structural Zn2+ binding site [ion binding]; other site 875328004159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328004160 dimerization interface [polypeptide binding]; other site 875328004161 putative DNA binding site [nucleotide binding]; other site 875328004162 putative Zn2+ binding site [ion binding]; other site 875328004163 glycyl-tRNA synthetase; Provisional; Region: PRK04173 875328004164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 875328004165 motif 1; other site 875328004166 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 875328004167 active site 875328004168 motif 2; other site 875328004169 motif 3; other site 875328004170 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 875328004171 anticodon binding site; other site 875328004172 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 875328004173 Repair protein; Region: Repair_PSII; pfam04536 875328004174 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 875328004175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 875328004176 Zn2+ binding site [ion binding]; other site 875328004177 Mg2+ binding site [ion binding]; other site 875328004178 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 875328004179 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328004180 DNA primase; Validated; Region: dnaG; PRK05667 875328004181 CHC2 zinc finger; Region: zf-CHC2; pfam01807 875328004182 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 875328004183 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 875328004184 active site 875328004185 metal binding site [ion binding]; metal-binding site 875328004186 interdomain interaction site; other site 875328004187 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 875328004188 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 875328004189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328004190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328004191 active site 875328004192 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 875328004193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328004195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328004197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 875328004198 PAS domain; Region: PAS_9; pfam13426 875328004199 putative active site [active] 875328004200 heme pocket [chemical binding]; other site 875328004201 GAF domain; Region: GAF; pfam01590 875328004202 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 875328004203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 875328004204 metal binding site [ion binding]; metal-binding site 875328004205 active site 875328004206 I-site; other site 875328004207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 875328004208 MarR family; Region: MarR; pfam01047 875328004209 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 875328004210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328004211 Walker A/P-loop; other site 875328004212 ATP binding site [chemical binding]; other site 875328004213 Q-loop/lid; other site 875328004214 ABC transporter signature motif; other site 875328004215 Walker B; other site 875328004216 D-loop; other site 875328004217 H-loop/switch region; other site 875328004218 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 875328004219 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 875328004220 Walker A/P-loop; other site 875328004221 ATP binding site [chemical binding]; other site 875328004222 Q-loop/lid; other site 875328004223 ABC transporter signature motif; other site 875328004224 Walker B; other site 875328004225 D-loop; other site 875328004226 H-loop/switch region; other site 875328004227 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 875328004228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 875328004229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 875328004230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 875328004231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328004232 dimer interface [polypeptide binding]; other site 875328004233 conserved gate region; other site 875328004234 putative PBP binding loops; other site 875328004235 ABC-ATPase subunit interface; other site 875328004236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328004237 putative PBP binding loops; other site 875328004238 ABC-ATPase subunit interface; other site 875328004239 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 875328004240 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 875328004241 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 875328004242 putative active site [active] 875328004243 homotetrameric interface [polypeptide binding]; other site 875328004244 metal binding site [ion binding]; metal-binding site 875328004245 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 875328004246 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 875328004247 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328004248 cyclase homology domain; Region: CHD; cd07302 875328004249 nucleotidyl binding site; other site 875328004250 metal binding site [ion binding]; metal-binding site 875328004251 dimer interface [polypeptide binding]; other site 875328004252 AAA ATPase domain; Region: AAA_16; pfam13191 875328004253 heat shock protein 90; Provisional; Region: PRK05218 875328004254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328004255 ATP binding site [chemical binding]; other site 875328004256 Mg2+ binding site [ion binding]; other site 875328004257 G-X-G motif; other site 875328004258 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328004259 PPE family; Region: PPE; pfam00823 875328004260 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328004261 PPE family; Region: PPE; pfam00823 875328004262 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 875328004263 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328004264 NAD(P) binding site [chemical binding]; other site 875328004265 Uncharacterized conserved protein [Function unknown]; Region: COG2128 875328004266 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328004267 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 875328004268 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 875328004269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328004270 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 875328004271 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328004272 PE-PPE domain; Region: PE-PPE; pfam08237 875328004273 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328004274 classical (c) SDRs; Region: SDR_c; cd05233 875328004275 short chain dehydrogenase; Provisional; Region: PRK05650 875328004276 NAD(P) binding site [chemical binding]; other site 875328004277 active site 875328004278 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 875328004279 dinuclear metal binding motif [ion binding]; other site 875328004280 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328004281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328004282 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 875328004283 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 875328004284 DNA binding residues [nucleotide binding] 875328004285 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 875328004286 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 875328004287 Cutinase; Region: Cutinase; pfam01083 875328004288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004289 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328004290 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328004291 [2Fe-2S] cluster binding site [ion binding]; other site 875328004292 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328004293 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 875328004294 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 875328004295 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 875328004296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328004297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328004298 active site 875328004299 ATP binding site [chemical binding]; other site 875328004300 substrate binding site [chemical binding]; other site 875328004301 activation loop (A-loop); other site 875328004302 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 875328004303 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 875328004304 classical (c) SDRs; Region: SDR_c; cd05233 875328004305 NAD(P) binding site [chemical binding]; other site 875328004306 active site 875328004307 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 875328004308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328004309 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328004310 acyl-activating enzyme (AAE) consensus motif; other site 875328004311 putative AMP binding site [chemical binding]; other site 875328004312 putative active site [active] 875328004313 putative CoA binding site [chemical binding]; other site 875328004314 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328004315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328004316 acyl-activating enzyme (AAE) consensus motif; other site 875328004317 AMP binding site [chemical binding]; other site 875328004318 active site 875328004319 CoA binding site [chemical binding]; other site 875328004320 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 875328004321 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 875328004322 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328004323 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 875328004324 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 875328004325 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 875328004326 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 875328004327 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 875328004328 RNA binding site [nucleotide binding]; other site 875328004329 FAD binding domain; Region: FAD_binding_4; pfam01565 875328004330 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 875328004331 hypothetical protein; Validated; Region: PRK07586 875328004332 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 875328004333 PYR/PP interface [polypeptide binding]; other site 875328004334 dimer interface [polypeptide binding]; other site 875328004335 TPP binding site [chemical binding]; other site 875328004336 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 875328004337 TPP-binding site [chemical binding]; other site 875328004338 dimer interface [polypeptide binding]; other site 875328004339 Cutinase; Region: Cutinase; pfam01083 875328004340 Cutinase; Region: Cutinase; pfam01083 875328004341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 875328004342 nucleotide binding site [chemical binding]; other site 875328004343 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 875328004344 Short C-terminal domain; Region: SHOCT; pfam09851 875328004345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328004346 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 875328004347 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 875328004348 NAD binding site [chemical binding]; other site 875328004349 catalytic Zn binding site [ion binding]; other site 875328004350 substrate binding site [chemical binding]; other site 875328004351 structural Zn binding site [ion binding]; other site 875328004352 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 875328004353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328004354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328004355 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 875328004356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 875328004357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328004358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328004359 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328004360 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 875328004361 diacylglycerol kinase; Reviewed; Region: PRK11914 875328004362 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 875328004363 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 875328004364 FAD binding domain; Region: FAD_binding_4; pfam01565 875328004365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328004367 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 875328004368 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 875328004369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 875328004370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 875328004371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 875328004372 short chain dehydrogenase; Provisional; Region: PRK12744 875328004373 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 875328004374 NADP binding site [chemical binding]; other site 875328004375 homodimer interface [polypeptide binding]; other site 875328004376 active site 875328004377 substrate binding site [chemical binding]; other site 875328004378 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328004379 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 875328004380 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328004381 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 875328004382 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 875328004383 dimer interface [polypeptide binding]; other site 875328004384 active site 875328004385 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 875328004386 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 875328004387 dimer interface [polypeptide binding]; other site 875328004388 active site 875328004389 acyl carrier protein; Provisional; Region: acpP; PRK00982 875328004390 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 875328004391 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 875328004392 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 875328004393 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 875328004394 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 875328004395 dimer interface [polypeptide binding]; other site 875328004396 TPP-binding site [chemical binding]; other site 875328004397 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 875328004398 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 875328004399 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 875328004400 dimer interface [polypeptide binding]; other site 875328004401 catalytic triad [active] 875328004402 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 875328004403 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 875328004404 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328004405 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 875328004406 Low molecular weight phosphatase family; Region: LMWPc; cd00115 875328004407 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 875328004408 active site 875328004409 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 875328004410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328004411 motif II; other site 875328004412 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 875328004413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 875328004414 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 875328004415 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 875328004416 Putative zinc ribbon domain; Region: DUF164; pfam02591 875328004417 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 875328004418 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 875328004419 RNA/DNA hybrid binding site [nucleotide binding]; other site 875328004420 active site 875328004421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328004422 catalytic core [active] 875328004423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328004424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328004425 sequence-specific DNA binding site [nucleotide binding]; other site 875328004426 salt bridge; other site 875328004427 Cupin domain; Region: Cupin_2; pfam07883 875328004428 serine O-acetyltransferase; Region: cysE; TIGR01172 875328004429 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 875328004430 trimer interface [polypeptide binding]; other site 875328004431 active site 875328004432 substrate binding site [chemical binding]; other site 875328004433 CoA binding site [chemical binding]; other site 875328004434 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 875328004435 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 875328004436 dimer interface [polypeptide binding]; other site 875328004437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328004438 catalytic residue [active] 875328004439 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 875328004440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328004441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328004442 S-adenosylmethionine binding site [chemical binding]; other site 875328004443 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 875328004444 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 875328004445 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 875328004446 active site 875328004447 oligomerization interface [polypeptide binding]; other site 875328004448 metal binding site [ion binding]; metal-binding site 875328004449 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 875328004450 TAP-like protein; Region: Abhydrolase_4; pfam08386 875328004451 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 875328004452 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 875328004453 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 875328004454 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 875328004455 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 875328004456 metal binding triad; other site 875328004457 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 875328004458 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 875328004459 metal binding triad; other site 875328004460 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 875328004461 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328004462 CoenzymeA binding site [chemical binding]; other site 875328004463 subunit interaction site [polypeptide binding]; other site 875328004464 PHB binding site; other site 875328004465 glutamine synthetase, type I; Region: GlnA; TIGR00653 875328004466 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 875328004467 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 875328004468 RDD family; Region: RDD; cl00746 875328004469 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 875328004470 lipoyl synthase; Provisional; Region: PRK05481 875328004471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328004472 FeS/SAM binding site; other site 875328004473 lipoate-protein ligase B; Provisional; Region: PRK14345 875328004474 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 875328004475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328004476 NAD(P) binding site [chemical binding]; other site 875328004477 active site 875328004478 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 875328004479 E3 interaction surface; other site 875328004480 lipoyl attachment site [posttranslational modification]; other site 875328004481 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 875328004482 E3 interaction surface; other site 875328004483 lipoyl attachment site [posttranslational modification]; other site 875328004484 e3 binding domain; Region: E3_binding; pfam02817 875328004485 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 875328004486 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 875328004487 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 875328004488 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 875328004489 interface (dimer of trimers) [polypeptide binding]; other site 875328004490 Substrate-binding/catalytic site; other site 875328004491 Zn-binding sites [ion binding]; other site 875328004492 cyclase homology domain; Region: CHD; cd07302 875328004493 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328004494 nucleotidyl binding site; other site 875328004495 metal binding site [ion binding]; metal-binding site 875328004496 dimer interface [polypeptide binding]; other site 875328004497 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 875328004498 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 875328004499 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 875328004500 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 875328004501 homodimer interface [polypeptide binding]; other site 875328004502 substrate-cofactor binding pocket; other site 875328004503 catalytic residue [active] 875328004504 cobalamin synthase; Reviewed; Region: cobS; PRK00235 875328004505 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 875328004506 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 875328004507 putative dimer interface [polypeptide binding]; other site 875328004508 active site pocket [active] 875328004509 putative cataytic base [active] 875328004510 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 875328004511 Glycerate kinase family; Region: Gly_kinase; cl00841 875328004512 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 875328004513 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 875328004514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 875328004515 substrate binding site [chemical binding]; other site 875328004516 ATP binding site [chemical binding]; other site 875328004517 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 875328004518 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 875328004519 active site 875328004520 dimer interface [polypeptide binding]; other site 875328004521 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 875328004522 Ligand Binding Site [chemical binding]; other site 875328004523 Molecular Tunnel; other site 875328004524 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 875328004525 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 875328004526 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 875328004527 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328004528 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 875328004529 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 875328004530 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 875328004531 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 875328004532 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 875328004533 heme bH binding site [chemical binding]; other site 875328004534 intrachain domain interface; other site 875328004535 heme bL binding site [chemical binding]; other site 875328004536 interchain domain interface [polypeptide binding]; other site 875328004537 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 875328004538 Qo binding site; other site 875328004539 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 875328004540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 875328004541 iron-sulfur cluster [ion binding]; other site 875328004542 [2Fe-2S] cluster binding site [ion binding]; other site 875328004543 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 875328004544 Cytochrome c; Region: Cytochrom_C; pfam00034 875328004545 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 875328004546 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 875328004547 Subunit I/III interface [polypeptide binding]; other site 875328004548 hypothetical protein; Validated; Region: PRK07883 875328004549 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 875328004550 active site 875328004551 catalytic site [active] 875328004552 substrate binding site [chemical binding]; other site 875328004553 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 875328004554 GIY-YIG motif/motif A; other site 875328004555 active site 875328004556 catalytic site [active] 875328004557 putative DNA binding site [nucleotide binding]; other site 875328004558 metal binding site [ion binding]; metal-binding site 875328004559 NlpC/P60 family; Region: NLPC_P60; pfam00877 875328004560 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 875328004561 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 875328004562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328004563 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328004564 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 875328004565 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 875328004566 acyl-activating enzyme (AAE) consensus motif; other site 875328004567 putative AMP binding site [chemical binding]; other site 875328004568 putative active site [active] 875328004569 putative CoA binding site [chemical binding]; other site 875328004570 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 875328004571 putative hydrophobic ligand binding site [chemical binding]; other site 875328004572 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 875328004573 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 875328004574 Nucleotide binding site [chemical binding]; other site 875328004575 DTAP/Switch II; other site 875328004576 Switch I; other site 875328004577 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328004578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328004579 putative acyl-acceptor binding pocket; other site 875328004580 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 875328004581 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 875328004582 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328004583 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 875328004584 active site 875328004585 ATP binding site [chemical binding]; other site 875328004586 substrate binding site [chemical binding]; other site 875328004587 activation loop (A-loop); other site 875328004588 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 875328004589 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 875328004590 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 875328004591 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 875328004592 substrate binding pocket [chemical binding]; other site 875328004593 chain length determination region; other site 875328004594 substrate-Mg2+ binding site; other site 875328004595 catalytic residues [active] 875328004596 aspartate-rich region 1; other site 875328004597 active site lid residues [active] 875328004598 aspartate-rich region 2; other site 875328004599 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 875328004600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 875328004601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 875328004602 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 875328004603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 875328004604 MraZ protein; Region: MraZ; pfam02381 875328004605 MraZ protein; Region: MraZ; pfam02381 875328004606 MraW methylase family; Region: Methyltransf_5; pfam01795 875328004607 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 875328004608 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 875328004609 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 875328004610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 875328004611 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 875328004612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 875328004613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 875328004614 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 875328004615 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 875328004616 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 875328004617 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 875328004618 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 875328004619 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 875328004620 Mg++ binding site [ion binding]; other site 875328004621 putative catalytic motif [active] 875328004622 putative substrate binding site [chemical binding]; other site 875328004623 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 875328004624 XdhC Rossmann domain; Region: XdhC_C; pfam13478 875328004625 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 875328004626 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 875328004627 cell division protein FtsW; Region: ftsW; TIGR02614 875328004628 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 875328004629 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 875328004630 active site 875328004631 homodimer interface [polypeptide binding]; other site 875328004632 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 875328004633 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 875328004634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 875328004635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 875328004636 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 875328004637 Cell division protein FtsQ; Region: FtsQ; pfam03799 875328004638 cell division protein FtsZ; Validated; Region: PRK09330 875328004639 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 875328004640 nucleotide binding site [chemical binding]; other site 875328004641 SulA interaction site; other site 875328004642 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 875328004643 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 875328004644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 875328004645 Predicted integral membrane protein [Function unknown]; Region: COG0762 875328004646 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 875328004647 DivIVA domain; Region: DivI1A_domain; TIGR03544 875328004648 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 875328004649 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 875328004650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328004651 active site 875328004652 hypothetical protein; Provisional; Region: PRK07906 875328004653 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 875328004654 putative metal binding site [ion binding]; other site 875328004655 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 875328004656 substrate binding site [chemical binding]; other site 875328004657 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 875328004658 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 875328004659 quinone interaction residues [chemical binding]; other site 875328004660 active site 875328004661 catalytic residues [active] 875328004662 FMN binding site [chemical binding]; other site 875328004663 substrate binding site [chemical binding]; other site 875328004664 MMPL family; Region: MMPL; pfam03176 875328004665 MMPL family; Region: MMPL; pfam03176 875328004666 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 875328004667 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 875328004668 malonyl-CoA binding site [chemical binding]; other site 875328004669 dimer interface [polypeptide binding]; other site 875328004670 active site 875328004671 product binding site; other site 875328004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 875328004673 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 875328004674 Putative zinc-finger; Region: zf-HC2; pfam13490 875328004675 RNA polymerase sigma factor; Provisional; Region: PRK12525 875328004676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328004677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328004678 DNA binding residues [nucleotide binding] 875328004679 Putative zinc-finger; Region: zf-HC2; pfam13490 875328004680 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 875328004681 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 875328004682 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 875328004683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328004684 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328004685 DNA binding residues [nucleotide binding] 875328004686 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 875328004687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328004688 catalytic core [active] 875328004689 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 875328004690 conserved hypothetical protein; Region: TIGR03843 875328004691 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 875328004692 active site 875328004693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328004694 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 875328004695 active site 875328004696 HIGH motif; other site 875328004697 nucleotide binding site [chemical binding]; other site 875328004698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328004699 active site 875328004700 KMSKS motif; other site 875328004701 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 875328004702 short chain dehydrogenase; Provisional; Region: PRK05872 875328004703 classical (c) SDRs; Region: SDR_c; cd05233 875328004704 NAD(P) binding site [chemical binding]; other site 875328004705 active site 875328004706 PAC2 family; Region: PAC2; pfam09754 875328004707 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 875328004708 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 875328004709 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 875328004710 substrate binding pocket [chemical binding]; other site 875328004711 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 875328004712 B12 binding site [chemical binding]; other site 875328004713 cobalt ligand [ion binding]; other site 875328004714 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 875328004715 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 875328004716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328004717 motif II; other site 875328004718 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 875328004719 homodimer interface [polypeptide binding]; other site 875328004720 putative metal binding site [ion binding]; other site 875328004721 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 875328004722 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 875328004723 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 875328004724 Predicted membrane protein [Function unknown]; Region: COG3918 875328004725 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 875328004726 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 875328004727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328004728 Protein of unknown function (DUF503); Region: DUF503; pfam04456 875328004729 proteasome ATPase; Region: pup_AAA; TIGR03689 875328004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328004731 Walker A motif; other site 875328004732 ATP binding site [chemical binding]; other site 875328004733 Walker B motif; other site 875328004734 arginine finger; other site 875328004735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328004737 Protein of unknown function, DUF479; Region: DUF479; cl01203 875328004738 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 875328004739 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 875328004740 Pup-like protein; Region: Pup; cl05289 875328004741 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 875328004742 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 875328004743 active site 875328004744 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 875328004745 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 875328004746 active site 875328004747 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 875328004748 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 875328004749 putative active site [active] 875328004750 lipid-transfer protein; Provisional; Region: PRK06059 875328004751 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328004752 active site 875328004753 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328004754 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328004755 DNA polymerase I; Provisional; Region: PRK05755 875328004756 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 875328004757 active site 875328004758 metal binding site 1 [ion binding]; metal-binding site 875328004759 putative 5' ssDNA interaction site; other site 875328004760 metal binding site 3; metal-binding site 875328004761 metal binding site 2 [ion binding]; metal-binding site 875328004762 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 875328004763 putative DNA binding site [nucleotide binding]; other site 875328004764 putative metal binding site [ion binding]; other site 875328004765 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 875328004766 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 875328004767 active site 875328004768 DNA binding site [nucleotide binding] 875328004769 catalytic site [active] 875328004770 Protease prsW family; Region: PrsW-protease; pfam13367 875328004771 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 875328004772 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 875328004773 RNA binding site [nucleotide binding]; other site 875328004774 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 875328004775 RNA binding site [nucleotide binding]; other site 875328004776 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 875328004777 RNA binding site [nucleotide binding]; other site 875328004778 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 875328004779 RNA binding site [nucleotide binding]; other site 875328004780 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 875328004781 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 875328004782 CoA-binding site [chemical binding]; other site 875328004783 ATP-binding [chemical binding]; other site 875328004784 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 875328004785 Protein of unknown function (DUF402); Region: DUF402; cl00979 875328004786 excinuclease ABC subunit B; Provisional; Region: PRK05298 875328004787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328004788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328004789 nucleotide binding region [chemical binding]; other site 875328004790 ATP-binding site [chemical binding]; other site 875328004791 Ultra-violet resistance protein B; Region: UvrB; pfam12344 875328004792 UvrB/uvrC motif; Region: UVR; pfam02151 875328004793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328004794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 875328004795 putative substrate translocation pore; other site 875328004796 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 875328004797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 875328004798 Ligand Binding Site [chemical binding]; other site 875328004799 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 875328004800 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 875328004801 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 875328004802 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 875328004803 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 875328004804 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 875328004805 putative active site [active] 875328004806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 875328004807 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 875328004808 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 875328004809 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 875328004810 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 875328004811 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 875328004812 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 875328004813 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 875328004814 23S rRNA binding site [nucleotide binding]; other site 875328004815 L21 binding site [polypeptide binding]; other site 875328004816 L13 binding site [polypeptide binding]; other site 875328004817 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 875328004818 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 875328004819 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 875328004820 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328004821 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328004822 cyclase homology domain; Region: CHD; cd07302 875328004823 nucleotidyl binding site; other site 875328004824 metal binding site [ion binding]; metal-binding site 875328004825 dimer interface [polypeptide binding]; other site 875328004826 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 875328004827 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 875328004828 dimer interface [polypeptide binding]; other site 875328004829 motif 1; other site 875328004830 active site 875328004831 motif 2; other site 875328004832 motif 3; other site 875328004833 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 875328004834 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 875328004835 putative tRNA-binding site [nucleotide binding]; other site 875328004836 B3/4 domain; Region: B3_4; pfam03483 875328004837 tRNA synthetase B5 domain; Region: B5; smart00874 875328004838 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 875328004839 dimer interface [polypeptide binding]; other site 875328004840 motif 1; other site 875328004841 motif 3; other site 875328004842 motif 2; other site 875328004843 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 875328004844 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 875328004845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328004846 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 875328004847 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 875328004848 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 875328004849 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 875328004850 heterotetramer interface [polypeptide binding]; other site 875328004851 active site pocket [active] 875328004852 cleavage site 875328004853 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 875328004854 feedback inhibition sensing region; other site 875328004855 homohexameric interface [polypeptide binding]; other site 875328004856 nucleotide binding site [chemical binding]; other site 875328004857 N-acetyl-L-glutamate binding site [chemical binding]; other site 875328004858 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 875328004859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 875328004860 inhibitor-cofactor binding pocket; inhibition site 875328004861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328004862 catalytic residue [active] 875328004863 ornithine carbamoyltransferase; Provisional; Region: PRK00779 875328004864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 875328004865 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 875328004866 arginine repressor; Provisional; Region: PRK03341 875328004867 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 875328004868 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 875328004869 argininosuccinate synthase; Provisional; Region: PRK13820 875328004870 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 875328004871 ANP binding site [chemical binding]; other site 875328004872 Substrate Binding Site II [chemical binding]; other site 875328004873 Substrate Binding Site I [chemical binding]; other site 875328004874 argininosuccinate lyase; Provisional; Region: PRK00855 875328004875 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 875328004876 active sites [active] 875328004877 tetramer interface [polypeptide binding]; other site 875328004878 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 875328004879 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 875328004880 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 875328004881 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 875328004882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328004883 ABC transporter; Region: ABC_tran_2; pfam12848 875328004884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328004885 acyl-CoA synthetase; Validated; Region: PRK07868 875328004886 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 875328004887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328004888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328004889 CoA binding site [chemical binding]; other site 875328004890 active site 875328004891 AMP binding site [chemical binding]; other site 875328004892 Uncharacterized conserved protein [Function unknown]; Region: COG2835 875328004893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328004894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328004895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 875328004896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 875328004897 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 875328004898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 875328004899 Walker A/P-loop; other site 875328004900 ATP binding site [chemical binding]; other site 875328004901 Q-loop/lid; other site 875328004902 ABC transporter signature motif; other site 875328004903 Walker B; other site 875328004904 D-loop; other site 875328004905 H-loop/switch region; other site 875328004906 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 875328004907 active site 875328004908 DNA binding site [nucleotide binding] 875328004909 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 875328004910 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 875328004911 active site 875328004912 HIGH motif; other site 875328004913 dimer interface [polypeptide binding]; other site 875328004914 KMSKS motif; other site 875328004915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 875328004916 RNA binding surface [nucleotide binding]; other site 875328004917 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 875328004918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328004919 active site 875328004920 motif I; other site 875328004921 motif II; other site 875328004922 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 875328004923 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 875328004924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 875328004925 RNA binding surface [nucleotide binding]; other site 875328004926 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 875328004927 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 875328004928 ATP-NAD kinase; Region: NAD_kinase; pfam01513 875328004929 DNA repair protein RecN; Region: recN; TIGR00634 875328004930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328004931 Walker A/P-loop; other site 875328004932 ATP binding site [chemical binding]; other site 875328004933 Q-loop/lid; other site 875328004934 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 875328004935 ABC transporter signature motif; other site 875328004936 Walker B; other site 875328004937 D-loop; other site 875328004938 H-loop/switch region; other site 875328004939 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 875328004940 Thiamine pyrophosphokinase; Region: TPK; cl08415 875328004941 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 875328004942 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 875328004943 CTP synthetase; Validated; Region: pyrG; PRK05380 875328004944 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 875328004945 Catalytic site [active] 875328004946 active site 875328004947 UTP binding site [chemical binding]; other site 875328004948 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 875328004949 active site 875328004950 putative oxyanion hole; other site 875328004951 catalytic triad [active] 875328004952 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 875328004953 dimer interface [polypeptide binding]; other site 875328004954 ADP-ribose binding site [chemical binding]; other site 875328004955 active site 875328004956 nudix motif; other site 875328004957 metal binding site [ion binding]; metal-binding site 875328004958 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 875328004959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 875328004960 active site 875328004961 DNA binding site [nucleotide binding] 875328004962 Int/Topo IB signature motif; other site 875328004963 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 875328004964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328004965 S-adenosylmethionine binding site [chemical binding]; other site 875328004966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 875328004967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328004968 P-loop; other site 875328004969 Magnesium ion binding site [ion binding]; other site 875328004970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328004971 Magnesium ion binding site [ion binding]; other site 875328004972 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 875328004973 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 875328004974 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 875328004975 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 875328004976 RNA binding surface [nucleotide binding]; other site 875328004977 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 875328004978 active site 875328004979 cytidylate kinase; Provisional; Region: cmk; PRK00023 875328004980 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 875328004981 CMP-binding site; other site 875328004982 The sites determining sugar specificity; other site 875328004983 GTP-binding protein Der; Reviewed; Region: PRK03003 875328004984 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 875328004985 GTP/Mg2+ binding site [chemical binding]; other site 875328004986 Switch I region; other site 875328004987 G2 box; other site 875328004988 Switch II region; other site 875328004989 G3 box; other site 875328004990 G4 box; other site 875328004991 G5 box; other site 875328004992 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 875328004993 G1 box; other site 875328004994 GTP/Mg2+ binding site [chemical binding]; other site 875328004995 Switch I region; other site 875328004996 G2 box; other site 875328004997 G3 box; other site 875328004998 Switch II region; other site 875328004999 G4 box; other site 875328005000 G5 box; other site 875328005001 hypothetical protein; Provisional; Region: PRK10621 875328005002 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 875328005003 Patatin-like phospholipase; Region: Patatin; pfam01734 875328005004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 875328005005 active site 875328005006 Int/Topo IB signature motif; other site 875328005007 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328005008 TspO/MBR family; Region: TspO_MBR; pfam03073 875328005009 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 875328005010 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 875328005011 potential catalytic triad [active] 875328005012 conserved cys residue [active] 875328005013 PIF1-like helicase; Region: PIF1; pfam05970 875328005014 AAA domain; Region: AAA_30; pfam13604 875328005015 Family description; Region: UvrD_C_2; pfam13538 875328005016 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 875328005017 malate dehydrogenase; Provisional; Region: PRK13529 875328005018 Malic enzyme, N-terminal domain; Region: malic; pfam00390 875328005019 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 875328005020 NAD(P) binding pocket [chemical binding]; other site 875328005021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328005022 guanine deaminase; Region: guan_deamin; TIGR02967 875328005023 active site 875328005024 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328005025 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 875328005026 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 875328005027 active site 875328005028 DNA binding site [nucleotide binding] 875328005029 Int/Topo IB signature motif; other site 875328005030 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328005031 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 875328005032 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 875328005033 Methyltransferase domain; Region: Methyltransf_18; pfam12847 875328005034 NlpC/P60 family; Region: NLPC_P60; cl17555 875328005035 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 875328005036 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 875328005037 Moco binding site; other site 875328005038 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 875328005039 metal coordination site [ion binding]; other site 875328005040 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 875328005041 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 875328005042 Moco binding site; other site 875328005043 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 875328005044 metal coordination site [ion binding]; other site 875328005045 Protein of unknown function (DUF690); Region: DUF690; cl04939 875328005046 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 875328005047 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328005048 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 875328005049 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328005050 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328005051 PE family; Region: PE; pfam00934 875328005052 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328005053 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328005054 EspG family; Region: ESX-1_EspG; pfam14011 875328005055 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 875328005056 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 875328005057 catalytic residues [active] 875328005058 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 875328005059 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 875328005060 active site 875328005061 catalytic residues [active] 875328005062 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 875328005063 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 875328005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328005065 Walker A motif; other site 875328005066 ATP binding site [chemical binding]; other site 875328005067 Walker B motif; other site 875328005068 arginine finger; other site 875328005069 PE family; Region: PE; pfam00934 875328005070 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328005071 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328005072 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005073 PPE family; Region: PPE; pfam00823 875328005074 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005075 PPE family; Region: PPE; pfam00823 875328005076 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005077 PPE family; Region: PPE; pfam00823 875328005078 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005079 PPE family; Region: PPE; pfam00823 875328005080 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328005081 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 875328005082 MgtC family; Region: MgtC; pfam02308 875328005083 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 875328005084 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 875328005085 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 875328005086 dimerization interface [polypeptide binding]; other site 875328005087 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 875328005088 mannose binding site [chemical binding]; other site 875328005089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 875328005090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 875328005091 active site 875328005092 hypothetical protein; Validated; Region: PRK07121 875328005093 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328005094 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 875328005095 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 875328005096 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 875328005097 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 875328005098 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 875328005099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328005100 nucleotide binding region [chemical binding]; other site 875328005101 ATP-binding site [chemical binding]; other site 875328005102 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 875328005103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 875328005104 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 875328005105 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 875328005106 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 875328005107 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 875328005108 lipoyl attachment site [posttranslational modification]; other site 875328005109 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 875328005110 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 875328005111 phosphopeptide binding site; other site 875328005112 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 875328005113 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 875328005114 DNA binding residues [nucleotide binding] 875328005115 Bifunctional nuclease; Region: DNase-RNase; pfam02577 875328005116 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 875328005117 DNA binding residues [nucleotide binding] 875328005118 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 875328005119 putative dimer interface [polypeptide binding]; other site 875328005120 glycine dehydrogenase; Provisional; Region: PRK05367 875328005121 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 875328005122 tetramer interface [polypeptide binding]; other site 875328005123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005124 catalytic residue [active] 875328005125 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 875328005126 tetramer interface [polypeptide binding]; other site 875328005127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005128 catalytic residue [active] 875328005129 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 875328005130 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 875328005131 metal ion-dependent adhesion site (MIDAS); other site 875328005132 malate synthase G; Provisional; Region: PRK02999 875328005133 active site 875328005134 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 875328005135 Domain of unknown function DUF21; Region: DUF21; pfam01595 875328005136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 875328005137 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 875328005138 Domain of unknown function DUF21; Region: DUF21; pfam01595 875328005139 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 875328005140 Transporter associated domain; Region: CorC_HlyC; smart01091 875328005141 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 875328005142 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328005143 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 875328005144 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 875328005145 active site 875328005146 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 875328005147 catalytic core [active] 875328005148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328005149 catalytic core [active] 875328005150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328005151 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328005152 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 875328005153 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 875328005154 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 875328005155 Predicted transcriptional regulator [Transcription]; Region: COG3682 875328005156 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328005157 CoenzymeA binding site [chemical binding]; other site 875328005158 subunit interaction site [polypeptide binding]; other site 875328005159 PHB binding site; other site 875328005160 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 875328005161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328005162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328005163 classical (c) SDRs; Region: SDR_c; cd05233 875328005164 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 875328005165 NAD(P) binding site [chemical binding]; other site 875328005166 active site 875328005167 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 875328005168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 875328005169 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 875328005170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328005171 dimer interface [polypeptide binding]; other site 875328005172 conserved gate region; other site 875328005173 putative PBP binding loops; other site 875328005174 ABC-ATPase subunit interface; other site 875328005175 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 875328005176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328005177 Walker A/P-loop; other site 875328005178 ATP binding site [chemical binding]; other site 875328005179 Q-loop/lid; other site 875328005180 ABC transporter signature motif; other site 875328005181 Walker B; other site 875328005182 D-loop; other site 875328005183 H-loop/switch region; other site 875328005184 TOBE domain; Region: TOBE; pfam03459 875328005185 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 875328005186 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 875328005187 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 875328005188 putative NAD(P) binding site [chemical binding]; other site 875328005189 putative substrate binding site [chemical binding]; other site 875328005190 catalytic Zn binding site [ion binding]; other site 875328005191 structural Zn binding site [ion binding]; other site 875328005192 CAAX protease self-immunity; Region: Abi; pfam02517 875328005193 putative phosphoketolase; Provisional; Region: PRK05261 875328005194 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 875328005195 TPP-binding site; other site 875328005196 XFP C-terminal domain; Region: XFP_C; pfam09363 875328005197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328005198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328005199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328005200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328005201 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 875328005202 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328005203 active site 875328005204 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 875328005205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328005206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328005207 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 875328005208 helix-hairpin-helix signature motif; other site 875328005209 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 875328005210 TrkA-N domain; Region: TrkA_N; pfam02254 875328005211 RyR domain; Region: RyR; pfam02026 875328005212 TIR domain; Region: TIR_2; pfam13676 875328005213 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328005214 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 875328005215 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328005216 phosphate binding site [ion binding]; other site 875328005217 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 875328005218 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 875328005219 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 875328005220 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 875328005221 dimer interface [polypeptide binding]; other site 875328005222 decamer (pentamer of dimers) interface [polypeptide binding]; other site 875328005223 catalytic triad [active] 875328005224 peroxidatic and resolving cysteines [active] 875328005225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 875328005226 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 875328005227 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 875328005228 dimerization interface [polypeptide binding]; other site 875328005229 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 875328005230 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 875328005231 heme binding site [chemical binding]; other site 875328005232 ferroxidase pore; other site 875328005233 ferroxidase diiron center [ion binding]; other site 875328005234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328005235 putative substrate translocation pore; other site 875328005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328005237 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 875328005238 Uncharacterized conserved protein [Function unknown]; Region: COG2128 875328005239 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328005240 Predicted acyl esterases [General function prediction only]; Region: COG2936 875328005241 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 875328005242 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 875328005243 hydrophobic ligand binding site; other site 875328005244 Predicted esterase [General function prediction only]; Region: COG0627 875328005245 YceI-like domain; Region: YceI; smart00867 875328005246 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 875328005247 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 875328005248 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 875328005249 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 875328005250 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328005251 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 875328005252 MoxR-like ATPases [General function prediction only]; Region: COG0714 875328005253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328005254 Walker A motif; other site 875328005255 ATP binding site [chemical binding]; other site 875328005256 Walker B motif; other site 875328005257 arginine finger; other site 875328005258 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 875328005259 Protein of unknown function DUF58; Region: DUF58; pfam01882 875328005260 Nitronate monooxygenase; Region: NMO; pfam03060 875328005261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328005262 FMN binding site [chemical binding]; other site 875328005263 substrate binding site [chemical binding]; other site 875328005264 putative catalytic residue [active] 875328005265 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 875328005266 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 875328005267 competence damage-inducible protein A; Provisional; Region: PRK00549 875328005268 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 875328005269 MPT binding site; other site 875328005270 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 875328005271 Lipase maturation factor; Region: LMF1; pfam06762 875328005272 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 875328005273 putative active site [active] 875328005274 dimerization interface [polypeptide binding]; other site 875328005275 putative tRNAtyr binding site [nucleotide binding]; other site 875328005276 Domain of unknown function DUF77; Region: DUF77; cl00307 875328005277 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 875328005278 hypothetical protein; Validated; Region: PRK02101 875328005279 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 875328005280 anti sigma factor interaction site; other site 875328005281 regulatory phosphorylation site [posttranslational modification]; other site 875328005282 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 875328005283 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 875328005284 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 875328005285 active site 875328005286 catalytic triad [active] 875328005287 oxyanion hole [active] 875328005288 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 875328005289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328005290 NAD(P) binding site [chemical binding]; other site 875328005291 active site 875328005292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 875328005293 Zn2+ binding site [ion binding]; other site 875328005294 Mg2+ binding site [ion binding]; other site 875328005295 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 875328005296 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 875328005297 conserved cys residue [active] 875328005298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328005299 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 875328005300 tetramer interface [polypeptide binding]; other site 875328005301 active site 875328005302 Mg2+/Mn2+ binding site [ion binding]; other site 875328005303 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 875328005304 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328005305 Transport protein; Region: actII; TIGR00833 875328005306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328005307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005308 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 875328005309 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328005310 acyl-activating enzyme (AAE) consensus motif; other site 875328005311 active site 875328005312 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005313 PPE family; Region: PPE; pfam00823 875328005314 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328005315 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328005316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328005317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005318 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 875328005319 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328005320 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328005321 substrate binding site [chemical binding]; other site 875328005322 oxyanion hole (OAH) forming residues; other site 875328005323 trimer interface [polypeptide binding]; other site 875328005324 YacP-like NYN domain; Region: NYN_YacP; cl01491 875328005325 Helix-turn-helix domain; Region: HTH_18; pfam12833 875328005326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328005327 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328005328 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328005329 hypothetical protein; Validated; Region: PRK07121 875328005330 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328005331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 875328005332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 875328005333 catalytic residue [active] 875328005334 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 875328005335 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 875328005336 Prostaglandin dehydrogenases; Region: PGDH; cd05288 875328005337 NAD(P) binding site [chemical binding]; other site 875328005338 substrate binding site [chemical binding]; other site 875328005339 dimer interface [polypeptide binding]; other site 875328005340 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 875328005341 dimer interface [polypeptide binding]; other site 875328005342 catalytic triad [active] 875328005343 peroxidatic and resolving cysteines [active] 875328005344 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328005345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005346 S-adenosylmethionine binding site [chemical binding]; other site 875328005347 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328005349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005350 S-adenosylmethionine binding site [chemical binding]; other site 875328005351 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 875328005352 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 875328005353 dimer interface [polypeptide binding]; other site 875328005354 active site 875328005355 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005357 S-adenosylmethionine binding site [chemical binding]; other site 875328005358 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328005359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328005360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005361 S-adenosylmethionine binding site [chemical binding]; other site 875328005362 TIGR03085 family protein; Region: TIGR03085 875328005363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005364 WHG domain; Region: WHG; pfam13305 875328005365 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 875328005366 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328005367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328005368 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 875328005369 Transcriptional regulators [Transcription]; Region: FadR; COG2186 875328005370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328005371 DNA-binding site [nucleotide binding]; DNA binding site 875328005372 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328005373 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328005374 active site 875328005375 Transcriptional regulators [Transcription]; Region: MarR; COG1846 875328005376 MarR family; Region: MarR_2; pfam12802 875328005377 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 875328005378 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 875328005379 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328005380 putative NAD(P) binding site [chemical binding]; other site 875328005381 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328005382 potential frameshift: common BLAST hit: gi|256392917|ref|YP_003114481.1| NADP oxidoreductase coenzyme F420-dependent 875328005383 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 875328005384 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 875328005385 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328005386 short chain dehydrogenase; Provisional; Region: PRK06500 875328005387 classical (c) SDRs; Region: SDR_c; cd05233 875328005388 NAD(P) binding site [chemical binding]; other site 875328005389 active site 875328005390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328005391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005392 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 875328005393 NAD(P) binding site [chemical binding]; other site 875328005394 active site lysine 875328005395 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 875328005396 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 875328005397 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 875328005398 Transposase, Mutator family; Region: Transposase_mut; pfam00872 875328005399 MULE transposase domain; Region: MULE; pfam10551 875328005400 Integrase core domain; Region: rve; pfam00665 875328005401 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 875328005402 Bacterial TniB protein; Region: TniB; pfam05621 875328005403 AAA domain; Region: AAA_22; pfam13401 875328005404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328005405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005406 Transport protein; Region: actII; TIGR00833 875328005407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 875328005408 catalytic triad [active] 875328005409 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 875328005410 putative ADP-ribose binding site [chemical binding]; other site 875328005411 putative active site [active] 875328005412 Ecdysteroid kinase; Region: EcKinase; cl17738 875328005413 Phosphotransferase enzyme family; Region: APH; pfam01636 875328005414 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 875328005415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328005416 ATP binding site [chemical binding]; other site 875328005417 putative Mg++ binding site [ion binding]; other site 875328005418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328005419 nucleotide binding region [chemical binding]; other site 875328005420 ATP-binding site [chemical binding]; other site 875328005421 Helicase associated domain (HA2); Region: HA2; pfam04408 875328005422 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 875328005423 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 875328005424 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 875328005425 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328005426 short chain dehydrogenase; Provisional; Region: PRK08278 875328005427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328005428 NAD(P) binding site [chemical binding]; other site 875328005429 active site 875328005430 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328005431 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328005432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005433 S-adenosylmethionine binding site [chemical binding]; other site 875328005434 aconitate hydratase; Validated; Region: PRK09277 875328005435 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 875328005436 substrate binding site [chemical binding]; other site 875328005437 ligand binding site [chemical binding]; other site 875328005438 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 875328005439 substrate binding site [chemical binding]; other site 875328005440 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 875328005441 gating phenylalanine in ion channel; other site 875328005442 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 875328005443 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 875328005444 Walker A/P-loop; other site 875328005445 ATP binding site [chemical binding]; other site 875328005446 Q-loop/lid; other site 875328005447 ABC transporter signature motif; other site 875328005448 Walker B; other site 875328005449 D-loop; other site 875328005450 H-loop/switch region; other site 875328005451 TOBE domain; Region: TOBE_2; pfam08402 875328005452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 875328005453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328005454 dimer interface [polypeptide binding]; other site 875328005455 conserved gate region; other site 875328005456 putative PBP binding loops; other site 875328005457 ABC-ATPase subunit interface; other site 875328005458 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 875328005459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328005460 dimer interface [polypeptide binding]; other site 875328005461 conserved gate region; other site 875328005462 putative PBP binding loops; other site 875328005463 ABC-ATPase subunit interface; other site 875328005464 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 875328005465 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 875328005466 Predicted membrane protein [Function unknown]; Region: COG1511 875328005467 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 875328005468 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 875328005469 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 875328005470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328005471 Walker A/P-loop; other site 875328005472 ATP binding site [chemical binding]; other site 875328005473 Q-loop/lid; other site 875328005474 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 875328005475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328005476 DoxX-like family; Region: DoxX_2; pfam13564 875328005477 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 875328005478 DNA binding residues [nucleotide binding] 875328005479 TOBE domain; Region: TOBE; cl01440 875328005480 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 875328005481 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 875328005482 Isochorismatase family; Region: Isochorismatase; pfam00857 875328005483 catalytic triad [active] 875328005484 metal binding site [ion binding]; metal-binding site 875328005485 conserved cis-peptide bond; other site 875328005486 RDD family; Region: RDD; pfam06271 875328005487 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328005488 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 875328005489 substrate binding pocket [chemical binding]; other site 875328005490 catalytic triad [active] 875328005491 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 875328005492 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 875328005493 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 875328005494 Ligand binding site; other site 875328005495 Putative Catalytic site; other site 875328005496 DXD motif; other site 875328005497 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 875328005498 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 875328005499 putative active site [active] 875328005500 catalytic triad [active] 875328005501 putative dimer interface [polypeptide binding]; other site 875328005502 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 875328005503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328005504 active site 875328005505 Dienelactone hydrolase family; Region: DLH; pfam01738 875328005506 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 875328005507 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 875328005508 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 875328005509 Hemerythrin-like domain; Region: Hr-like; cd12108 875328005510 Fe binding site [ion binding]; other site 875328005511 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 875328005512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328005513 NAD(P) binding site [chemical binding]; other site 875328005514 active site 875328005515 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 875328005516 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 875328005517 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 875328005518 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 875328005519 active site 875328005520 5'-3' exonuclease; Region: 53EXOc; smart00475 875328005521 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 875328005522 active site 875328005523 putative 5' ssDNA interaction site; other site 875328005524 metal binding site 3; metal-binding site 875328005525 metal binding site 1 [ion binding]; metal-binding site 875328005526 metal binding site 2 [ion binding]; metal-binding site 875328005527 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 875328005528 putative DNA binding site [nucleotide binding]; other site 875328005529 putative metal binding site [ion binding]; other site 875328005530 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 875328005531 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 875328005532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328005533 ATP binding site [chemical binding]; other site 875328005534 putative Mg++ binding site [ion binding]; other site 875328005535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328005536 ATP-binding site [chemical binding]; other site 875328005537 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 875328005538 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 875328005539 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 875328005540 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 875328005541 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 875328005542 Predicted transcriptional regulator [Transcription]; Region: COG2378 875328005543 WYL domain; Region: WYL; pfam13280 875328005544 Predicted transcriptional regulator [Transcription]; Region: COG2378 875328005545 WYL domain; Region: WYL; pfam13280 875328005546 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 875328005547 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 875328005548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328005549 active site 875328005550 phosphorylation site [posttranslational modification] 875328005551 intermolecular recognition site; other site 875328005552 dimerization interface [polypeptide binding]; other site 875328005553 ANTAR domain; Region: ANTAR; pfam03861 875328005554 hypothetical protein; Provisional; Region: PRK02237 875328005555 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 875328005556 cyclase homology domain; Region: CHD; cd07302 875328005557 nucleotidyl binding site; other site 875328005558 metal binding site [ion binding]; metal-binding site 875328005559 dimer interface [polypeptide binding]; other site 875328005560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328005561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328005562 substrate binding pocket [chemical binding]; other site 875328005563 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328005564 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 875328005565 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 875328005566 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 875328005567 active site 875328005568 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 875328005569 catalytic triad [active] 875328005570 dimer interface [polypeptide binding]; other site 875328005571 pyruvate kinase; Provisional; Region: PRK06247 875328005572 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 875328005573 domain interfaces; other site 875328005574 active site 875328005575 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 875328005576 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 875328005577 substrate binding site [chemical binding]; other site 875328005578 active site 875328005579 catalytic residues [active] 875328005580 heterodimer interface [polypeptide binding]; other site 875328005581 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 875328005582 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 875328005583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005584 catalytic residue [active] 875328005585 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 875328005586 active site 875328005587 ribulose/triose binding site [chemical binding]; other site 875328005588 phosphate binding site [ion binding]; other site 875328005589 substrate (anthranilate) binding pocket [chemical binding]; other site 875328005590 product (indole) binding pocket [chemical binding]; other site 875328005591 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 875328005592 anthranilate synthase component I; Provisional; Region: PRK13571 875328005593 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 875328005594 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 875328005595 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 875328005596 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 875328005597 catalytic triad [active] 875328005598 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 875328005599 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 875328005600 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 875328005601 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 875328005602 substrate binding site [chemical binding]; other site 875328005603 glutamase interaction surface [polypeptide binding]; other site 875328005604 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 875328005605 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 875328005606 active site 875328005607 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 875328005608 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 875328005609 catalytic residues [active] 875328005610 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 875328005611 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 875328005612 putative active site [active] 875328005613 oxyanion strand; other site 875328005614 catalytic triad [active] 875328005615 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 875328005616 putative active site pocket [active] 875328005617 4-fold oligomerization interface [polypeptide binding]; other site 875328005618 metal binding residues [ion binding]; metal-binding site 875328005619 3-fold/trimer interface [polypeptide binding]; other site 875328005620 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 875328005621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328005622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005623 homodimer interface [polypeptide binding]; other site 875328005624 catalytic residue [active] 875328005625 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 875328005626 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 875328005627 NAD binding site [chemical binding]; other site 875328005628 dimerization interface [polypeptide binding]; other site 875328005629 product binding site; other site 875328005630 substrate binding site [chemical binding]; other site 875328005631 zinc binding site [ion binding]; other site 875328005632 catalytic residues [active] 875328005633 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328005634 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328005635 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 875328005636 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 875328005637 dimerization interface [polypeptide binding]; other site 875328005638 active site 875328005639 L-aspartate oxidase; Provisional; Region: PRK07804 875328005640 L-aspartate oxidase; Provisional; Region: PRK06175 875328005641 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 875328005642 quinolinate synthetase; Provisional; Region: PRK09375 875328005643 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 875328005644 nudix motif; other site 875328005645 Secretory lipase; Region: LIP; pfam03583 875328005646 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 875328005647 biotin synthase; Validated; Region: PRK06256 875328005648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328005649 FeS/SAM binding site; other site 875328005650 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 875328005651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005652 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 875328005653 Integrase core domain; Region: rve; pfam00665 875328005654 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 875328005655 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 875328005656 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 875328005657 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 875328005658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328005659 catalytic residue [active] 875328005660 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 875328005661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 875328005662 inhibitor-cofactor binding pocket; inhibition site 875328005663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005664 catalytic residue [active] 875328005665 NlpC/P60 family; Region: NLPC_P60; pfam00877 875328005666 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 875328005667 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 875328005668 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 875328005669 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 875328005670 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 875328005671 active site 875328005672 catalytic site [active] 875328005673 Uncharacterized conserved protein [Function unknown]; Region: COG2966 875328005674 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 875328005675 threonine dehydratase; Validated; Region: PRK08639 875328005676 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 875328005677 tetramer interface [polypeptide binding]; other site 875328005678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328005679 catalytic residue [active] 875328005680 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 875328005681 Domain of unknown function (DUF385); Region: DUF385; pfam04075 875328005682 Protein of unknown function, DUF488; Region: DUF488; pfam04343 875328005683 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 875328005684 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 875328005685 acyl-activating enzyme (AAE) consensus motif; other site 875328005686 putative AMP binding site [chemical binding]; other site 875328005687 putative active site [active] 875328005688 putative CoA binding site [chemical binding]; other site 875328005689 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328005690 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328005691 substrate binding site [chemical binding]; other site 875328005692 oxyanion hole (OAH) forming residues; other site 875328005693 trimer interface [polypeptide binding]; other site 875328005694 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328005695 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 875328005696 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 875328005697 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 875328005698 DNA binding residues [nucleotide binding] 875328005699 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 875328005700 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 875328005701 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 875328005702 active site 875328005703 PHP Thumb interface [polypeptide binding]; other site 875328005704 metal binding site [ion binding]; metal-binding site 875328005705 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 875328005706 generic binding surface II; other site 875328005707 generic binding surface I; other site 875328005708 Uncharacterized conserved protein [Function unknown]; Region: COG3360 875328005709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005710 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 875328005711 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 875328005712 active site 875328005713 lipoprotein signal peptidase; Provisional; Region: PRK14764 875328005714 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 875328005715 active site 875328005716 homotetramer interface [polypeptide binding]; other site 875328005717 homodimer interface [polypeptide binding]; other site 875328005718 DNA polymerase IV; Provisional; Region: PRK03348 875328005719 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 875328005720 active site 875328005721 DNA binding site [nucleotide binding] 875328005722 Methyltransferase domain; Region: Methyltransf_23; pfam13489 875328005723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005724 S-adenosylmethionine binding site [chemical binding]; other site 875328005725 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 875328005726 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 875328005727 HIGH motif; other site 875328005728 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 875328005729 active site 875328005730 KMSKS motif; other site 875328005731 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 875328005732 tRNA binding surface [nucleotide binding]; other site 875328005733 anticodon binding site; other site 875328005734 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 875328005735 Hemerythrin-like domain; Region: Hr-like; cd12108 875328005736 OsmC-like protein; Region: OsmC; cl00767 875328005737 Transport protein; Region: actII; TIGR00833 875328005738 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328005739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328005740 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 875328005741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005742 S-adenosylmethionine binding site [chemical binding]; other site 875328005743 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328005744 Cytochrome P450; Region: p450; cl12078 875328005745 short chain dehydrogenase; Validated; Region: PRK06182 875328005746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328005747 NAD(P) binding site [chemical binding]; other site 875328005748 active site 875328005749 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 875328005750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328005751 S-adenosylmethionine binding site [chemical binding]; other site 875328005752 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 875328005753 classical (c) SDRs; Region: SDR_c; cd05233 875328005754 NAD(P) binding site [chemical binding]; other site 875328005755 active site 875328005756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328005757 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 875328005758 PE-PPE domain; Region: PE-PPE; pfam08237 875328005759 Nitroreductase family; Region: Nitroreductase; pfam00881 875328005760 FMN binding site [chemical binding]; other site 875328005761 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 875328005762 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 875328005763 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328005764 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 875328005765 acyltransferase PapA5; Provisional; Region: PRK09294 875328005766 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 875328005767 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328005768 active site 875328005769 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 875328005770 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328005771 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328005772 Condensation domain; Region: Condensation; pfam00668 875328005773 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 875328005774 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328005775 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 875328005776 active site 875328005777 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328005778 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 875328005779 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 875328005780 putative NADP binding site [chemical binding]; other site 875328005781 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 875328005782 active site 875328005783 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328005784 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 875328005785 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328005786 active site 875328005787 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328005788 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 875328005789 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 875328005790 KR domain; Region: KR; pfam08659 875328005791 putative NADP binding site [chemical binding]; other site 875328005792 active site 875328005793 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328005794 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328005795 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 875328005796 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328005797 active site 875328005798 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328005799 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 875328005800 KR domain; Region: KR; pfam08659 875328005801 NADP binding site [chemical binding]; other site 875328005802 active site 875328005803 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328005804 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 875328005805 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328005806 active site 875328005807 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328005808 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 875328005809 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 875328005810 KR domain; Region: KR; pfam08659 875328005811 putative NADP binding site [chemical binding]; other site 875328005812 active site 875328005813 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328005814 acyl-CoA synthetase; Validated; Region: PRK05850 875328005815 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328005816 acyl-activating enzyme (AAE) consensus motif; other site 875328005817 active site 875328005818 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 875328005819 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328005820 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328005821 membrane ATPase/protein kinase; Provisional; Region: PRK09435 875328005822 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 875328005823 Walker A; other site 875328005824 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 875328005825 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 875328005826 active site 875328005827 substrate binding site [chemical binding]; other site 875328005828 coenzyme B12 binding site [chemical binding]; other site 875328005829 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 875328005830 B12 binding site [chemical binding]; other site 875328005831 cobalt ligand [ion binding]; other site 875328005832 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 875328005833 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 875328005834 heterodimer interface [polypeptide binding]; other site 875328005835 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 875328005836 Uncharacterized conserved protein [Function unknown]; Region: COG0398 875328005837 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 875328005838 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328005839 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 875328005840 amphipathic channel; other site 875328005841 Asn-Pro-Ala signature motifs; other site 875328005842 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 875328005843 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 875328005844 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 875328005845 ferrochelatase; Reviewed; Region: hemH; PRK00035 875328005846 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 875328005847 C-terminal domain interface [polypeptide binding]; other site 875328005848 active site 875328005849 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 875328005850 active site 875328005851 N-terminal domain interface [polypeptide binding]; other site 875328005852 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 875328005853 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 875328005854 NAD binding site [chemical binding]; other site 875328005855 homotetramer interface [polypeptide binding]; other site 875328005856 homodimer interface [polypeptide binding]; other site 875328005857 substrate binding site [chemical binding]; other site 875328005858 active site 875328005859 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 875328005860 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328005861 NAD(P) binding site [chemical binding]; other site 875328005862 homotetramer interface [polypeptide binding]; other site 875328005863 homodimer interface [polypeptide binding]; other site 875328005864 active site 875328005865 hypothetical protein; Provisional; Region: PRK13685 875328005866 von Willebrand factor type A domain; Region: VWA_2; pfam13519 875328005867 metal ion-dependent adhesion site (MIDAS); other site 875328005868 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 875328005869 Protein of unknown function DUF58; Region: DUF58; pfam01882 875328005870 MoxR-like ATPases [General function prediction only]; Region: COG0714 875328005871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328005872 Walker A motif; other site 875328005873 ATP binding site [chemical binding]; other site 875328005874 Walker B motif; other site 875328005875 arginine finger; other site 875328005876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 875328005877 NlpC/P60 family; Region: NLPC_P60; pfam00877 875328005878 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 875328005879 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 875328005880 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 875328005881 NlpC/P60 family; Region: NLPC_P60; pfam00877 875328005882 aconitate hydratase; Validated; Region: PRK09277 875328005883 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 875328005884 substrate binding site [chemical binding]; other site 875328005885 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 875328005886 ligand binding site [chemical binding]; other site 875328005887 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 875328005888 substrate binding site [chemical binding]; other site 875328005889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328005890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328005891 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 875328005892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328005893 Walker A/P-loop; other site 875328005894 ATP binding site [chemical binding]; other site 875328005895 Q-loop/lid; other site 875328005896 ABC transporter signature motif; other site 875328005897 Walker B; other site 875328005898 D-loop; other site 875328005899 H-loop/switch region; other site 875328005900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 875328005901 enoyl-CoA hydratase; Provisional; Region: PRK05864 875328005902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328005903 substrate binding site [chemical binding]; other site 875328005904 oxyanion hole (OAH) forming residues; other site 875328005905 trimer interface [polypeptide binding]; other site 875328005906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 875328005907 catalytic residues [active] 875328005908 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 875328005909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328005910 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 875328005911 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 875328005912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328005913 motif II; other site 875328005914 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 875328005915 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 875328005916 active site 875328005917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328005918 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 875328005919 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 875328005920 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 875328005921 trimerization site [polypeptide binding]; other site 875328005922 active site 875328005923 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 875328005924 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 875328005925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328005926 catalytic residue [active] 875328005927 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 875328005928 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 875328005929 Walker A/P-loop; other site 875328005930 ATP binding site [chemical binding]; other site 875328005931 Q-loop/lid; other site 875328005932 ABC transporter signature motif; other site 875328005933 Walker B; other site 875328005934 D-loop; other site 875328005935 H-loop/switch region; other site 875328005936 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 875328005937 FeS assembly protein SufD; Region: sufD; TIGR01981 875328005938 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 875328005939 FeS assembly protein SufB; Region: sufB; TIGR01980 875328005940 Predicted transcriptional regulator [Transcription]; Region: COG2345 875328005941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328005942 putative DNA binding site [nucleotide binding]; other site 875328005943 putative Zn2+ binding site [ion binding]; other site 875328005944 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 875328005945 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 875328005946 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 875328005947 Walker A/P-loop; other site 875328005948 ATP binding site [chemical binding]; other site 875328005949 Q-loop/lid; other site 875328005950 ABC transporter signature motif; other site 875328005951 Walker B; other site 875328005952 D-loop; other site 875328005953 H-loop/switch region; other site 875328005954 ABC-2 type transporter; Region: ABC2_membrane; cl17235 875328005955 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 875328005956 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 875328005957 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 875328005958 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 875328005959 NADP binding site [chemical binding]; other site 875328005960 dimer interface [polypeptide binding]; other site 875328005961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005962 PPE family; Region: PPE; pfam00823 875328005963 PPE family; Region: PPE; pfam00823 875328005964 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328005965 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 875328005966 UbiA prenyltransferase family; Region: UbiA; pfam01040 875328005967 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 875328005968 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 875328005969 TPP-binding site [chemical binding]; other site 875328005970 dimer interface [polypeptide binding]; other site 875328005971 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 875328005972 PYR/PP interface [polypeptide binding]; other site 875328005973 dimer interface [polypeptide binding]; other site 875328005974 TPP binding site [chemical binding]; other site 875328005975 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 875328005976 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 875328005977 putative active site [active] 875328005978 transaldolase; Provisional; Region: PRK03903 875328005979 catalytic residue [active] 875328005980 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 875328005981 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 875328005982 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 875328005983 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 875328005984 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 875328005985 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 875328005986 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 875328005987 putative active site [active] 875328005988 triosephosphate isomerase; Provisional; Region: PRK14567 875328005989 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 875328005990 substrate binding site [chemical binding]; other site 875328005991 dimer interface [polypeptide binding]; other site 875328005992 catalytic triad [active] 875328005993 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 875328005994 Phosphoglycerate kinase; Region: PGK; pfam00162 875328005995 substrate binding site [chemical binding]; other site 875328005996 hinge regions; other site 875328005997 ADP binding site [chemical binding]; other site 875328005998 catalytic site [active] 875328005999 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 875328006000 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 875328006001 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 875328006002 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 875328006003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 875328006004 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 875328006005 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 875328006006 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 875328006007 phosphate binding site [ion binding]; other site 875328006008 putative substrate binding pocket [chemical binding]; other site 875328006009 dimer interface [polypeptide binding]; other site 875328006010 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 875328006011 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 875328006012 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 875328006013 GIY-YIG motif/motif A; other site 875328006014 active site 875328006015 catalytic site [active] 875328006016 putative DNA binding site [nucleotide binding]; other site 875328006017 metal binding site [ion binding]; metal-binding site 875328006018 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 875328006019 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 875328006020 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 875328006021 homopentamer interface [polypeptide binding]; other site 875328006022 active site 875328006023 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 875328006024 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 875328006025 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 875328006026 dimerization interface [polypeptide binding]; other site 875328006027 active site 875328006028 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 875328006029 Lumazine binding domain; Region: Lum_binding; pfam00677 875328006030 Lumazine binding domain; Region: Lum_binding; pfam00677 875328006031 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 875328006032 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 875328006033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328006034 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 875328006035 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 875328006036 catalytic motif [active] 875328006037 Zn binding site [ion binding]; other site 875328006038 RibD C-terminal domain; Region: RibD_C; pfam01872 875328006039 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 875328006040 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 875328006041 substrate binding site [chemical binding]; other site 875328006042 hexamer interface [polypeptide binding]; other site 875328006043 metal binding site [ion binding]; metal-binding site 875328006044 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 875328006045 putative RNA binding site [nucleotide binding]; other site 875328006046 16S rRNA methyltransferase B; Provisional; Region: PRK14902 875328006047 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 875328006048 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 875328006049 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 875328006050 putative active site [active] 875328006051 substrate binding site [chemical binding]; other site 875328006052 putative cosubstrate binding site; other site 875328006053 catalytic site [active] 875328006054 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 875328006055 substrate binding site [chemical binding]; other site 875328006056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 875328006057 Predicted kinase [General function prediction only]; Region: COG0645 875328006058 AAA domain; Region: AAA_17; pfam13207 875328006059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 875328006060 Ligand Binding Site [chemical binding]; other site 875328006061 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 875328006062 Ligand Binding Site [chemical binding]; other site 875328006063 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 875328006064 primosome assembly protein PriA; Provisional; Region: PRK14873 875328006065 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 875328006066 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 875328006067 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 875328006068 Predicted membrane protein [Function unknown]; Region: COG3714 875328006069 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328006070 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328006071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328006072 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 875328006073 S-adenosylmethionine synthetase; Validated; Region: PRK05250 875328006074 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 875328006075 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 875328006076 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 875328006077 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 875328006078 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 875328006079 Flavoprotein; Region: Flavoprotein; pfam02441 875328006080 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 875328006081 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 875328006082 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 875328006083 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 875328006084 catalytic site [active] 875328006085 G-X2-G-X-G-K; other site 875328006086 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 875328006087 active site 875328006088 dimer interface [polypeptide binding]; other site 875328006089 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 875328006090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328006091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328006092 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 875328006093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328006094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328006095 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 875328006096 IMP binding site; other site 875328006097 dimer interface [polypeptide binding]; other site 875328006098 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 875328006099 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 875328006100 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 875328006101 catalytic site [active] 875328006102 subunit interface [polypeptide binding]; other site 875328006103 dihydroorotase; Validated; Region: pyrC; PRK09357 875328006104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328006105 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 875328006106 active site 875328006107 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 875328006108 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 875328006109 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 875328006110 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 875328006111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328006112 active site 875328006113 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328006114 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328006115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328006116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328006117 active site 875328006118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006120 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 875328006121 L-aspartate oxidase; Provisional; Region: PRK06175 875328006122 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 875328006123 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 875328006124 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 875328006125 Walker A/P-loop; other site 875328006126 ATP binding site [chemical binding]; other site 875328006127 Q-loop/lid; other site 875328006128 ABC transporter signature motif; other site 875328006129 Walker B; other site 875328006130 D-loop; other site 875328006131 H-loop/switch region; other site 875328006132 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 875328006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328006134 dimer interface [polypeptide binding]; other site 875328006135 conserved gate region; other site 875328006136 putative PBP binding loops; other site 875328006137 ABC-ATPase subunit interface; other site 875328006138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 875328006139 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 875328006140 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 875328006141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328006142 DNA-binding site [nucleotide binding]; DNA binding site 875328006143 UTRA domain; Region: UTRA; pfam07702 875328006144 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 875328006145 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328006146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328006147 catalytic residue [active] 875328006148 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 875328006149 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 875328006150 putative RNA binding site [nucleotide binding]; other site 875328006151 elongation factor P; Validated; Region: PRK00529 875328006152 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 875328006153 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 875328006154 RNA binding site [nucleotide binding]; other site 875328006155 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 875328006156 RNA binding site [nucleotide binding]; other site 875328006157 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 875328006158 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 875328006159 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 875328006160 active site 875328006161 Dehydroquinase class II; Region: DHquinase_II; pfam01220 875328006162 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 875328006163 trimer interface [polypeptide binding]; other site 875328006164 active site 875328006165 dimer interface [polypeptide binding]; other site 875328006166 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 875328006167 active site 875328006168 dimer interface [polypeptide binding]; other site 875328006169 metal binding site [ion binding]; metal-binding site 875328006170 shikimate kinase; Reviewed; Region: aroK; PRK00131 875328006171 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 875328006172 ADP binding site [chemical binding]; other site 875328006173 magnesium binding site [ion binding]; other site 875328006174 putative shikimate binding site; other site 875328006175 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 875328006176 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 875328006177 Tetramer interface [polypeptide binding]; other site 875328006178 active site 875328006179 FMN-binding site [chemical binding]; other site 875328006180 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 875328006181 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 875328006182 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 875328006183 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 875328006184 shikimate binding site; other site 875328006185 NAD(P) binding site [chemical binding]; other site 875328006186 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 875328006187 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 875328006188 dimerization interface [polypeptide binding]; other site 875328006189 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 875328006190 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 875328006191 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 875328006192 motif 1; other site 875328006193 active site 875328006194 motif 2; other site 875328006195 motif 3; other site 875328006196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 875328006197 Uncharacterized conserved protein [Function unknown]; Region: COG0432 875328006198 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 875328006199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328006200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328006201 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 875328006202 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 875328006203 active site 875328006204 non-prolyl cis peptide bond; other site 875328006205 Transcriptional regulators [Transcription]; Region: GntR; COG1802 875328006206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328006207 DNA-binding site [nucleotide binding]; DNA binding site 875328006208 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 875328006209 recombination factor protein RarA; Reviewed; Region: PRK13342 875328006210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328006211 Walker A motif; other site 875328006212 ATP binding site [chemical binding]; other site 875328006213 Walker B motif; other site 875328006214 arginine finger; other site 875328006215 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 875328006216 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328006217 Transposase, Mutator family; Region: Transposase_mut; pfam00872 875328006218 MULE transposase domain; Region: MULE; pfam10551 875328006219 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328006220 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328006221 active site 875328006222 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 875328006223 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 875328006224 NAD binding site [chemical binding]; other site 875328006225 catalytic Zn binding site [ion binding]; other site 875328006226 substrate binding site [chemical binding]; other site 875328006227 structural Zn binding site [ion binding]; other site 875328006228 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 875328006229 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 875328006230 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328006231 CoenzymeA binding site [chemical binding]; other site 875328006232 subunit interaction site [polypeptide binding]; other site 875328006233 PHB binding site; other site 875328006234 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 875328006235 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 875328006236 dimer interface [polypeptide binding]; other site 875328006237 anticodon binding site; other site 875328006238 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 875328006239 homodimer interface [polypeptide binding]; other site 875328006240 motif 1; other site 875328006241 active site 875328006242 motif 2; other site 875328006243 GAD domain; Region: GAD; pfam02938 875328006244 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 875328006245 active site 875328006246 motif 3; other site 875328006247 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328006248 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 875328006249 PPE family; Region: PPE; pfam00823 875328006250 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328006251 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328006252 Predicted metalloprotease [General function prediction only]; Region: COG2321 875328006253 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 875328006254 dihydrodipicolinate synthase; Region: dapA; TIGR00674 875328006255 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 875328006256 inhibitor site; inhibition site 875328006257 active site 875328006258 dimer interface [polypeptide binding]; other site 875328006259 catalytic residue [active] 875328006260 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 875328006261 intersubunit interface [polypeptide binding]; other site 875328006262 active site 875328006263 Zn2+ binding site [ion binding]; other site 875328006264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328006265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328006266 non-specific DNA binding site [nucleotide binding]; other site 875328006267 salt bridge; other site 875328006268 sequence-specific DNA binding site [nucleotide binding]; other site 875328006269 Cupin domain; Region: Cupin_2; pfam07883 875328006270 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 875328006271 putative active site pocket [active] 875328006272 dimerization interface [polypeptide binding]; other site 875328006273 putative catalytic residue [active] 875328006274 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 875328006275 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 875328006276 dimer interface [polypeptide binding]; other site 875328006277 motif 1; other site 875328006278 active site 875328006279 motif 2; other site 875328006280 motif 3; other site 875328006281 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 875328006282 anticodon binding site; other site 875328006283 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 875328006284 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 875328006285 active site 875328006286 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 875328006287 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 875328006288 Zn2+ binding site [ion binding]; other site 875328006289 Mg2+ binding site [ion binding]; other site 875328006290 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 875328006291 synthetase active site [active] 875328006292 NTP binding site [chemical binding]; other site 875328006293 metal binding site [ion binding]; metal-binding site 875328006294 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 875328006295 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 875328006296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328006297 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 875328006298 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 875328006299 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 875328006300 Protein export membrane protein; Region: SecD_SecF; pfam02355 875328006301 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 875328006302 Protein export membrane protein; Region: SecD_SecF; cl14618 875328006303 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 875328006304 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 875328006305 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 875328006306 inhibitor-cofactor binding pocket; inhibition site 875328006307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328006308 catalytic residue [active] 875328006309 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 875328006310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328006311 Walker A motif; other site 875328006312 ATP binding site [chemical binding]; other site 875328006313 Walker B motif; other site 875328006314 arginine finger; other site 875328006315 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 875328006316 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 875328006317 RuvA N terminal domain; Region: RuvA_N; pfam01330 875328006318 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 875328006319 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 875328006320 active site 875328006321 putative DNA-binding cleft [nucleotide binding]; other site 875328006322 dimer interface [polypeptide binding]; other site 875328006323 hypothetical protein; Validated; Region: PRK00110 875328006324 potential frameshift: common BLAST hit: gi|119717780|ref|YP_924745.1| endoglycoceramidase 875328006325 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 875328006326 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 875328006327 conserved cys residue [active] 875328006328 acyl-CoA thioesterase II; Region: tesB; TIGR00189 875328006329 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 875328006330 active site 875328006331 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 875328006332 catalytic triad [active] 875328006333 dimer interface [polypeptide binding]; other site 875328006334 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 875328006335 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 875328006336 active site 875328006337 multimer interface [polypeptide binding]; other site 875328006338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006340 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 875328006341 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 875328006342 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 875328006343 NAD(P) binding site [chemical binding]; other site 875328006344 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 875328006345 nudix motif; other site 875328006346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328006347 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328006348 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 875328006349 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 875328006350 putative acyl-acceptor binding pocket; other site 875328006351 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 875328006352 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 875328006353 nucleotide binding site/active site [active] 875328006354 HIT family signature motif; other site 875328006355 catalytic residue [active] 875328006356 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 875328006357 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 875328006358 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 875328006359 active site 875328006360 dimer interface [polypeptide binding]; other site 875328006361 motif 1; other site 875328006362 motif 2; other site 875328006363 motif 3; other site 875328006364 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 875328006365 anticodon binding site; other site 875328006366 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328006367 CoenzymeA binding site [chemical binding]; other site 875328006368 subunit interaction site [polypeptide binding]; other site 875328006369 PHB binding site; other site 875328006370 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 875328006371 Helix-turn-helix domain; Region: HTH_20; pfam12840 875328006372 Predicted transcriptional regulator [Transcription]; Region: COG2345 875328006373 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328006374 FMN binding site [chemical binding]; other site 875328006375 substrate binding site [chemical binding]; other site 875328006376 putative catalytic residue [active] 875328006377 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 875328006378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328006379 Predicted transcriptional regulator [Transcription]; Region: COG2345 875328006380 putative DNA binding site [nucleotide binding]; other site 875328006381 putative Zn2+ binding site [ion binding]; other site 875328006382 Ferredoxin [Energy production and conversion]; Region: COG1146 875328006383 4Fe-4S binding domain; Region: Fer4; cl02805 875328006384 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 875328006385 Cupin domain; Region: Cupin_2; cl17218 875328006386 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328006387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328006388 substrate binding site [chemical binding]; other site 875328006389 oxyanion hole (OAH) forming residues; other site 875328006390 trimer interface [polypeptide binding]; other site 875328006391 acyl-CoA synthetase; Validated; Region: PRK07798 875328006392 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328006393 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 875328006394 acyl-activating enzyme (AAE) consensus motif; other site 875328006395 acyl-activating enzyme (AAE) consensus motif; other site 875328006396 putative AMP binding site [chemical binding]; other site 875328006397 putative active site [active] 875328006398 putative CoA binding site [chemical binding]; other site 875328006399 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 875328006400 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 875328006401 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 875328006402 Clp amino terminal domain; Region: Clp_N; pfam02861 875328006403 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 875328006404 hypothetical protein; Provisional; Region: PRK14059 875328006405 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 875328006406 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328006407 TAP-like protein; Region: Abhydrolase_4; pfam08386 875328006408 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 875328006409 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 875328006410 SelR domain; Region: SelR; pfam01641 875328006411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328006412 S-adenosylmethionine binding site [chemical binding]; other site 875328006413 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 875328006414 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 875328006415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328006416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328006417 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 875328006418 substrate binding site [chemical binding]; other site 875328006419 active site 875328006420 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 875328006421 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 875328006422 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 875328006423 catalytic site [active] 875328006424 putative active site [active] 875328006425 putative substrate binding site [chemical binding]; other site 875328006426 HRDC domain; Region: HRDC; cl02578 875328006427 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 875328006428 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 875328006429 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 875328006430 TPP-binding site; other site 875328006431 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 875328006432 PYR/PP interface [polypeptide binding]; other site 875328006433 dimer interface [polypeptide binding]; other site 875328006434 TPP binding site [chemical binding]; other site 875328006435 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 875328006436 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 875328006437 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 875328006438 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 875328006439 transmembrane helices; other site 875328006440 TRAM domain; Region: TRAM; pfam01938 875328006441 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 875328006442 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 875328006443 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 875328006444 TrkA-N domain; Region: TrkA_N; pfam02254 875328006445 TrkA-C domain; Region: TrkA_C; pfam02080 875328006446 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 875328006447 TrkA-N domain; Region: TrkA_N; pfam02254 875328006448 TrkA-C domain; Region: TrkA_C; pfam02080 875328006449 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 875328006450 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 875328006451 generic binding surface II; other site 875328006452 ssDNA binding site; other site 875328006453 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 875328006454 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 875328006455 trimer interface [polypeptide binding]; other site 875328006456 active site 875328006457 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 875328006458 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 875328006459 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 875328006460 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 875328006461 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 875328006462 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 875328006463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328006464 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 875328006465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328006466 DNA binding residues [nucleotide binding] 875328006467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328006468 dimerization interface [polypeptide binding]; other site 875328006469 putative DNA binding site [nucleotide binding]; other site 875328006470 putative Zn2+ binding site [ion binding]; other site 875328006471 O-methyltransferase; Region: Methyltransf_2; pfam00891 875328006472 Protein of unknown function (DUF952); Region: DUF952; cl01393 875328006473 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 875328006474 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 875328006475 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 875328006476 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 875328006477 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 875328006478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328006479 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 875328006480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328006481 DNA binding residues [nucleotide binding] 875328006482 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 875328006483 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 875328006484 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 875328006485 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 875328006486 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 875328006487 PAC2 family; Region: PAC2; pfam09754 875328006488 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 875328006489 heme-binding site [chemical binding]; other site 875328006490 ATP cone domain; Region: ATP-cone; pfam03477 875328006491 LysM domain; Region: LysM; pfam01476 875328006492 LexA repressor; Validated; Region: PRK00215 875328006493 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 875328006494 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 875328006495 Catalytic site [active] 875328006496 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 875328006497 active site 875328006498 Predicted transcriptional regulator [Transcription]; Region: COG2345 875328006499 Helix-turn-helix domain; Region: HTH_20; pfam12840 875328006500 dimerization interface [polypeptide binding]; other site 875328006501 putative DNA binding site [nucleotide binding]; other site 875328006502 putative Zn2+ binding site [ion binding]; other site 875328006503 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328006504 FMN binding site [chemical binding]; other site 875328006505 substrate binding site [chemical binding]; other site 875328006506 putative catalytic residue [active] 875328006507 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 875328006508 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328006509 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 875328006510 LGFP repeat; Region: LGFP; pfam08310 875328006511 LGFP repeat; Region: LGFP; pfam08310 875328006512 LGFP repeat; Region: LGFP; pfam08310 875328006513 LGFP repeat; Region: LGFP; pfam08310 875328006514 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 875328006515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328006516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328006517 active site 875328006518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 875328006519 DEAD-like helicases superfamily; Region: DEXDc; smart00487 875328006520 ATP binding site [chemical binding]; other site 875328006521 putative Mg++ binding site [ion binding]; other site 875328006522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328006523 nucleotide binding region [chemical binding]; other site 875328006524 ATP-binding site [chemical binding]; other site 875328006525 GTPases [General function prediction only]; Region: HflX; COG2262 875328006526 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 875328006527 HflX GTPase family; Region: HflX; cd01878 875328006528 G1 box; other site 875328006529 GTP/Mg2+ binding site [chemical binding]; other site 875328006530 Switch I region; other site 875328006531 G2 box; other site 875328006532 G3 box; other site 875328006533 Switch II region; other site 875328006534 G4 box; other site 875328006535 G5 box; other site 875328006536 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 875328006537 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 875328006538 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 875328006539 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 875328006540 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 875328006541 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 875328006542 active site 875328006543 metal binding site [ion binding]; metal-binding site 875328006544 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 875328006545 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 875328006546 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 875328006547 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 875328006548 putative hydrophobic ligand binding site [chemical binding]; other site 875328006549 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 875328006550 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 875328006551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328006552 FeS/SAM binding site; other site 875328006553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 875328006554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 875328006555 Walker A/P-loop; other site 875328006556 ATP binding site [chemical binding]; other site 875328006557 Q-loop/lid; other site 875328006558 ABC transporter signature motif; other site 875328006559 Walker B; other site 875328006560 D-loop; other site 875328006561 H-loop/switch region; other site 875328006562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 875328006563 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 875328006564 substrate binding pocket [chemical binding]; other site 875328006565 membrane-bound complex binding site; other site 875328006566 hinge residues; other site 875328006567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328006568 dimer interface [polypeptide binding]; other site 875328006569 putative PBP binding loops; other site 875328006570 ABC-ATPase subunit interface; other site 875328006571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328006572 dimer interface [polypeptide binding]; other site 875328006573 conserved gate region; other site 875328006574 putative PBP binding loops; other site 875328006575 ABC-ATPase subunit interface; other site 875328006576 recombination regulator RecX; Reviewed; Region: recX; PRK00117 875328006577 recA bacterial DNA recombination protein; Region: RecA; cl17211 875328006578 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 875328006579 protein-splicing catalytic site; other site 875328006580 thioester formation/cholesterol transfer; other site 875328006581 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 875328006582 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 875328006583 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 875328006584 recA bacterial DNA recombination protein; Region: RecA; cl17211 875328006585 protein-splicing catalytic site; other site 875328006586 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 875328006587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006589 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 875328006590 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 875328006591 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 875328006592 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328006593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328006594 S-adenosylmethionine binding site [chemical binding]; other site 875328006595 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 875328006596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328006597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328006598 non-specific DNA binding site [nucleotide binding]; other site 875328006599 salt bridge; other site 875328006600 sequence-specific DNA binding site [nucleotide binding]; other site 875328006601 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 875328006602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328006603 Coenzyme A binding pocket [chemical binding]; other site 875328006604 Predicted membrane protein [Function unknown]; Region: COG2323 875328006605 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328006606 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328006607 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 875328006608 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328006609 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 875328006610 Uncharacterized conserved protein [Function unknown]; Region: COG1359 875328006611 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 875328006612 classical (c) SDRs; Region: SDR_c; cd05233 875328006613 NAD(P) binding site [chemical binding]; other site 875328006614 active site 875328006615 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 875328006616 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328006617 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 875328006618 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 875328006619 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 875328006620 dimer interface [polypeptide binding]; other site 875328006621 active site 875328006622 catalytic residue [active] 875328006623 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 875328006624 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328006625 Predicted membrane protein [Function unknown]; Region: COG2259 875328006626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 875328006627 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 875328006628 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 875328006629 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 875328006630 folate binding site [chemical binding]; other site 875328006631 NADP+ binding site [chemical binding]; other site 875328006632 thymidylate synthase; Reviewed; Region: thyA; PRK01827 875328006633 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 875328006634 dimerization interface [polypeptide binding]; other site 875328006635 active site 875328006636 Dienelactone hydrolase family; Region: DLH; pfam01738 875328006637 metabolite-proton symporter; Region: 2A0106; TIGR00883 875328006638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328006639 putative substrate translocation pore; other site 875328006640 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328006641 Phosphotransferase enzyme family; Region: APH; pfam01636 875328006642 putative active site [active] 875328006643 putative substrate binding site [chemical binding]; other site 875328006644 ATP binding site [chemical binding]; other site 875328006645 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 875328006646 classical (c) SDRs; Region: SDR_c; cd05233 875328006647 NAD(P) binding site [chemical binding]; other site 875328006648 active site 875328006649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328006650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328006651 active site 875328006652 classical (c) SDRs; Region: SDR_c; cd05233 875328006653 NAD(P) binding site [chemical binding]; other site 875328006654 active site 875328006655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006657 RmuC family; Region: RmuC; pfam02646 875328006658 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328006659 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 875328006660 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328006661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 875328006662 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328006663 carboxyltransferase (CT) interaction site; other site 875328006664 biotinylation site [posttranslational modification]; other site 875328006665 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328006666 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 875328006667 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328006668 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328006669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328006670 acyl-activating enzyme (AAE) consensus motif; other site 875328006671 acyl-activating enzyme (AAE) consensus motif; other site 875328006672 AMP binding site [chemical binding]; other site 875328006673 active site 875328006674 CoA binding site [chemical binding]; other site 875328006675 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 875328006676 dihydrodipicolinate reductase; Provisional; Region: PRK00048 875328006677 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 875328006678 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 875328006679 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328006680 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328006681 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 875328006682 FMN-binding pocket [chemical binding]; other site 875328006683 flavin binding motif; other site 875328006684 phosphate binding motif [ion binding]; other site 875328006685 beta-alpha-beta structure motif; other site 875328006686 NAD binding pocket [chemical binding]; other site 875328006687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328006688 catalytic loop [active] 875328006689 iron binding site [ion binding]; other site 875328006690 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328006691 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 875328006692 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 875328006693 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 875328006694 PE family; Region: PE; pfam00934 875328006695 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328006696 PPE family; Region: PPE; pfam00823 875328006697 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328006698 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328006699 Nitronate monooxygenase; Region: NMO; pfam03060 875328006700 FMN binding site [chemical binding]; other site 875328006701 substrate binding site [chemical binding]; other site 875328006702 putative catalytic residue [active] 875328006703 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 875328006704 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 875328006705 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 875328006706 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 875328006707 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 875328006708 oligomer interface [polypeptide binding]; other site 875328006709 RNA binding site [nucleotide binding]; other site 875328006710 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 875328006711 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 875328006712 RNase E interface [polypeptide binding]; other site 875328006713 trimer interface [polypeptide binding]; other site 875328006714 active site 875328006715 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 875328006716 putative nucleic acid binding region [nucleotide binding]; other site 875328006717 G-X-X-G motif; other site 875328006718 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 875328006719 RNA binding site [nucleotide binding]; other site 875328006720 domain interface; other site 875328006721 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 875328006722 16S/18S rRNA binding site [nucleotide binding]; other site 875328006723 S13e-L30e interaction site [polypeptide binding]; other site 875328006724 25S rRNA binding site [nucleotide binding]; other site 875328006725 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 875328006726 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 875328006727 active site 875328006728 Riboflavin kinase; Region: Flavokinase; pfam01687 875328006729 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 875328006730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328006731 putative DNA binding site [nucleotide binding]; other site 875328006732 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 875328006733 FeoA domain; Region: FeoA; pfam04023 875328006734 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 875328006735 hydrophobic ligand binding site; other site 875328006736 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328006737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328006738 active site 875328006739 short chain dehydrogenase; Provisional; Region: PRK07791 875328006740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328006741 NAD(P) binding site [chemical binding]; other site 875328006742 active site 875328006743 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 875328006744 active site 875328006745 catalytic site [active] 875328006746 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328006747 active site 2 [active] 875328006748 active site 1 [active] 875328006749 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 875328006750 hydrophobic ligand binding site; other site 875328006751 lipid-transfer protein; Provisional; Region: PRK08256 875328006752 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328006753 active site 875328006754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006756 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 875328006757 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 875328006758 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 875328006759 RNA binding site [nucleotide binding]; other site 875328006760 active site 875328006761 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 875328006762 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 875328006763 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 875328006764 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 875328006765 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 875328006766 active site 875328006767 metal binding site [ion binding]; metal-binding site 875328006768 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 875328006769 Predicted acyl esterases [General function prediction only]; Region: COG2936 875328006770 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 875328006771 PPE family; Region: PPE; pfam00823 875328006772 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328006773 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 875328006774 enoyl-CoA hydratase; Provisional; Region: PRK06190 875328006775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328006776 substrate binding site [chemical binding]; other site 875328006777 oxyanion hole (OAH) forming residues; other site 875328006778 trimer interface [polypeptide binding]; other site 875328006779 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 875328006780 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 875328006781 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 875328006782 DHH family; Region: DHH; pfam01368 875328006783 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 875328006784 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 875328006785 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 875328006786 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 875328006787 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 875328006788 G1 box; other site 875328006789 putative GEF interaction site [polypeptide binding]; other site 875328006790 GTP/Mg2+ binding site [chemical binding]; other site 875328006791 Switch I region; other site 875328006792 G2 box; other site 875328006793 G3 box; other site 875328006794 Switch II region; other site 875328006795 G4 box; other site 875328006796 G5 box; other site 875328006797 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 875328006798 Translation-initiation factor 2; Region: IF-2; pfam11987 875328006799 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 875328006800 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 875328006801 NusA N-terminal domain; Region: NusA_N; pfam08529 875328006802 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 875328006803 RNA binding site [nucleotide binding]; other site 875328006804 homodimer interface [polypeptide binding]; other site 875328006805 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 875328006806 G-X-X-G motif; other site 875328006807 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 875328006808 G-X-X-G motif; other site 875328006809 ribosome maturation protein RimP; Reviewed; Region: PRK00092 875328006810 Sm and related proteins; Region: Sm_like; cl00259 875328006811 heptamer interface [polypeptide binding]; other site 875328006812 Sm1 motif; other site 875328006813 hexamer interface [polypeptide binding]; other site 875328006814 RNA binding site [nucleotide binding]; other site 875328006815 Sm2 motif; other site 875328006816 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 875328006817 dinuclear metal binding motif [ion binding]; other site 875328006818 prolyl-tRNA synthetase; Provisional; Region: PRK09194 875328006819 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 875328006820 dimer interface [polypeptide binding]; other site 875328006821 motif 1; other site 875328006822 active site 875328006823 motif 2; other site 875328006824 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 875328006825 putative deacylase active site [active] 875328006826 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 875328006827 active site 875328006828 motif 3; other site 875328006829 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 875328006830 anticodon binding site; other site 875328006831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328006832 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 875328006833 putative substrate translocation pore; other site 875328006834 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 875328006835 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 875328006836 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 875328006837 homodimer interface [polypeptide binding]; other site 875328006838 active site 875328006839 SAM binding site [chemical binding]; other site 875328006840 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 875328006841 malate:quinone oxidoreductase; Validated; Region: PRK05257 875328006842 mycothione reductase; Reviewed; Region: PRK07846 875328006843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328006844 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 875328006845 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328006846 active site 875328006847 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 875328006848 tetracycline repressor protein TetR; Provisional; Region: PRK13756 875328006849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006850 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 875328006851 Methyltransferase domain; Region: Methyltransf_23; pfam13489 875328006852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328006853 S-adenosylmethionine binding site [chemical binding]; other site 875328006854 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328006855 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328006856 active site 875328006857 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328006858 classical (c) SDRs; Region: SDR_c; cd05233 875328006859 NAD(P) binding site [chemical binding]; other site 875328006860 active site 875328006861 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 875328006862 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328006863 NAD(P) binding site [chemical binding]; other site 875328006864 catalytic residues [active] 875328006865 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 875328006866 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 875328006867 catalytic triad [active] 875328006868 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 875328006869 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 875328006870 acyl-CoA synthetase; Validated; Region: PRK05850 875328006871 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328006872 acyl-activating enzyme (AAE) consensus motif; other site 875328006873 active site 875328006874 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328006875 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 875328006876 active site 875328006877 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 875328006878 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 875328006879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 875328006880 Predicted acetyltransferase [General function prediction only]; Region: COG3393 875328006881 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 875328006882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 875328006883 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 875328006884 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 875328006885 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 875328006886 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 875328006887 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 875328006888 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 875328006889 active site 875328006890 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 875328006891 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 875328006892 putative substrate binding region [chemical binding]; other site 875328006893 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 875328006894 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 875328006895 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 875328006896 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 875328006897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 875328006898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 875328006899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 875328006900 Helix-turn-helix domain; Region: HTH_18; pfam12833 875328006901 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 875328006902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328006903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328006904 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 875328006905 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 875328006906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328006907 FeS/SAM binding site; other site 875328006908 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 875328006909 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 875328006910 ribosome recycling factor; Reviewed; Region: frr; PRK00083 875328006911 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 875328006912 hinge region; other site 875328006913 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 875328006914 putative nucleotide binding site [chemical binding]; other site 875328006915 uridine monophosphate binding site [chemical binding]; other site 875328006916 homohexameric interface [polypeptide binding]; other site 875328006917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328006918 dimerization interface [polypeptide binding]; other site 875328006919 putative DNA binding site [nucleotide binding]; other site 875328006920 putative Zn2+ binding site [ion binding]; other site 875328006921 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 875328006922 hydrogenase 4 subunit B; Validated; Region: PRK06521 875328006923 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328006924 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 875328006925 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 875328006926 hydrogenase 4 subunit F; Validated; Region: PRK06458 875328006927 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328006928 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 875328006929 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 875328006930 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 875328006931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328006932 MarR family; Region: MarR; pfam01047 875328006933 amidase; Provisional; Region: PRK07869 875328006934 Amidase; Region: Amidase; pfam01425 875328006935 elongation factor Ts; Provisional; Region: tsf; PRK09377 875328006936 UBA/TS-N domain; Region: UBA; pfam00627 875328006937 Elongation factor TS; Region: EF_TS; pfam00889 875328006938 Elongation factor TS; Region: EF_TS; pfam00889 875328006939 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 875328006940 rRNA interaction site [nucleotide binding]; other site 875328006941 S8 interaction site; other site 875328006942 putative laminin-1 binding site; other site 875328006943 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 875328006944 Peptidase family M23; Region: Peptidase_M23; pfam01551 875328006945 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328006946 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328006947 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 875328006948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 875328006949 active site 875328006950 DNA binding site [nucleotide binding] 875328006951 Int/Topo IB signature motif; other site 875328006952 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 875328006953 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 875328006954 putative active site [active] 875328006955 putative substrate binding site [chemical binding]; other site 875328006956 putative FMN binding site [chemical binding]; other site 875328006957 putative catalytic residues [active] 875328006958 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 875328006959 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 875328006960 FAD binding pocket [chemical binding]; other site 875328006961 FAD binding motif [chemical binding]; other site 875328006962 phosphate binding motif [ion binding]; other site 875328006963 NAD binding pocket [chemical binding]; other site 875328006964 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 875328006965 DNA protecting protein DprA; Region: dprA; TIGR00732 875328006966 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 875328006967 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 875328006968 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 875328006969 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 875328006970 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 875328006971 hypothetical protein; Reviewed; Region: PRK12497 875328006972 Prephenate dehydrogenase; Region: PDH; pfam02153 875328006973 PE-PPE domain; Region: PE-PPE; pfam08237 875328006974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328006975 Coenzyme A binding pocket [chemical binding]; other site 875328006976 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 875328006977 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 875328006978 RNA/DNA hybrid binding site [nucleotide binding]; other site 875328006979 active site 875328006980 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 875328006981 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 875328006982 Catalytic site [active] 875328006983 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 875328006984 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 875328006985 Beta-lactamase; Region: Beta-lactamase; cl17358 875328006986 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 875328006987 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 875328006988 RimM N-terminal domain; Region: RimM; pfam01782 875328006989 PRC-barrel domain; Region: PRC; pfam05239 875328006990 hypothetical protein; Provisional; Region: PRK02821 875328006991 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 875328006992 G-X-X-G motif; other site 875328006993 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 875328006994 SnoaL-like domain; Region: SnoaL_4; pfam13577 875328006995 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 875328006996 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 875328006997 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 875328006998 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328006999 active site 875328007000 signal recognition particle protein; Provisional; Region: PRK10867 875328007001 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 875328007002 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 875328007003 P loop; other site 875328007004 GTP binding site [chemical binding]; other site 875328007005 Signal peptide binding domain; Region: SRP_SPB; pfam02978 875328007006 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 875328007007 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328007008 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328007009 substrate binding site [chemical binding]; other site 875328007010 oxyanion hole (OAH) forming residues; other site 875328007011 trimer interface [polypeptide binding]; other site 875328007012 PE-PPE domain; Region: PE-PPE; pfam08237 875328007013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328007014 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 875328007015 NAD(P) binding site [chemical binding]; other site 875328007016 active site 875328007017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007019 S-adenosylmethionine binding site [chemical binding]; other site 875328007020 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 875328007021 putative active site [active] 875328007022 putative CoA binding site [chemical binding]; other site 875328007023 nudix motif; other site 875328007024 metal binding site [ion binding]; metal-binding site 875328007025 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 875328007026 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 875328007027 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 875328007028 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328007029 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 875328007030 putative active site [active] 875328007031 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 875328007032 AAA domain; Region: AAA_23; pfam13476 875328007033 Walker A/P-loop; other site 875328007034 ATP binding site [chemical binding]; other site 875328007035 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 875328007036 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 875328007037 ABC transporter signature motif; other site 875328007038 Walker B; other site 875328007039 D-loop; other site 875328007040 H-loop/switch region; other site 875328007041 Acylphosphatase; Region: Acylphosphatase; cl00551 875328007042 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 875328007043 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328007044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328007045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328007046 DNA binding residues [nucleotide binding] 875328007047 dimerization interface [polypeptide binding]; other site 875328007048 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 875328007049 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 875328007050 conserved cys residue [active] 875328007051 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 875328007052 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 875328007053 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 875328007054 DNA binding site [nucleotide binding] 875328007055 catalytic residue [active] 875328007056 H2TH interface [polypeptide binding]; other site 875328007057 putative catalytic residues [active] 875328007058 turnover-facilitating residue; other site 875328007059 intercalation triad [nucleotide binding]; other site 875328007060 8OG recognition residue [nucleotide binding]; other site 875328007061 putative reading head residues; other site 875328007062 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 875328007063 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 875328007064 ribonuclease III; Reviewed; Region: rnc; PRK00102 875328007065 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 875328007066 dimerization interface [polypeptide binding]; other site 875328007067 active site 875328007068 metal binding site [ion binding]; metal-binding site 875328007069 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 875328007070 dsRNA binding site [nucleotide binding]; other site 875328007071 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 875328007072 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 875328007073 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 875328007074 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 875328007075 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 875328007076 putative active site [active] 875328007077 putative substrate binding site [chemical binding]; other site 875328007078 putative cosubstrate binding site; other site 875328007079 catalytic site [active] 875328007080 GXWXG protein; Region: GXWXG; pfam14231 875328007081 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 875328007082 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 875328007083 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 875328007084 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 875328007085 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 875328007086 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 875328007087 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 875328007088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007090 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328007091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328007092 active site 875328007093 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 875328007094 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 875328007095 active site 875328007096 (T/H)XGH motif; other site 875328007097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007098 S-adenosylmethionine binding site [chemical binding]; other site 875328007099 pyruvate carboxylase; Reviewed; Region: PRK12999 875328007100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328007101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328007102 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 875328007103 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 875328007104 active site 875328007105 catalytic residues [active] 875328007106 metal binding site [ion binding]; metal-binding site 875328007107 homodimer binding site [polypeptide binding]; other site 875328007108 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328007109 carboxyltransferase (CT) interaction site; other site 875328007110 biotinylation site [posttranslational modification]; other site 875328007111 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 875328007112 putative active site [active] 875328007113 redox center [active] 875328007114 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 875328007115 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 875328007116 catalytic residues [active] 875328007117 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328007118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 875328007119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 875328007120 active site 875328007121 catalytic tetrad [active] 875328007122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 875328007123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 875328007124 active site 875328007125 catalytic tetrad [active] 875328007126 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 875328007127 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 875328007128 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 875328007129 generic binding surface II; other site 875328007130 ssDNA binding site; other site 875328007131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328007132 ATP binding site [chemical binding]; other site 875328007133 putative Mg++ binding site [ion binding]; other site 875328007134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328007135 nucleotide binding region [chemical binding]; other site 875328007136 ATP-binding site [chemical binding]; other site 875328007137 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 875328007138 DAK2 domain; Region: Dak2; pfam02734 875328007139 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 875328007140 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 875328007141 ligand binding site [chemical binding]; other site 875328007142 active site 875328007143 UGI interface [polypeptide binding]; other site 875328007144 catalytic site [active] 875328007145 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 875328007146 thiamine monophosphate kinase; Provisional; Region: PRK05731 875328007147 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 875328007148 ATP binding site [chemical binding]; other site 875328007149 dimerization interface [polypeptide binding]; other site 875328007150 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 875328007151 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 875328007152 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 875328007153 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 875328007154 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 875328007155 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 875328007156 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 875328007157 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 875328007158 polyphosphate kinase; Provisional; Region: PRK05443 875328007159 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 875328007160 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 875328007161 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 875328007162 putative domain interface [polypeptide binding]; other site 875328007163 putative active site [active] 875328007164 catalytic site [active] 875328007165 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 875328007166 putative domain interface [polypeptide binding]; other site 875328007167 putative active site [active] 875328007168 catalytic site [active] 875328007169 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 875328007170 active site 875328007171 Ap6A binding site [chemical binding]; other site 875328007172 nudix motif; other site 875328007173 metal binding site [ion binding]; metal-binding site 875328007174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328007175 catalytic core [active] 875328007176 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 875328007177 IHF - DNA interface [nucleotide binding]; other site 875328007178 IHF dimer interface [polypeptide binding]; other site 875328007179 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 875328007180 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 875328007181 substrate binding site [chemical binding]; other site 875328007182 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 875328007183 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 875328007184 substrate binding site [chemical binding]; other site 875328007185 ligand binding site [chemical binding]; other site 875328007186 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 875328007187 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328007188 Bacterial transcriptional regulator; Region: IclR; pfam01614 875328007189 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 875328007190 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 875328007191 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 875328007192 HIGH motif; other site 875328007193 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 875328007194 active site 875328007195 KMSKS motif; other site 875328007196 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 875328007197 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 875328007198 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 875328007199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328007200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 875328007201 putative substrate translocation pore; other site 875328007202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328007203 Coenzyme A binding pocket [chemical binding]; other site 875328007204 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 875328007205 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 875328007206 inhibitor-cofactor binding pocket; inhibition site 875328007207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328007208 catalytic residue [active] 875328007209 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 875328007210 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 875328007211 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 875328007212 putative amidase; Provisional; Region: PRK06169 875328007213 Amidase; Region: Amidase; pfam01425 875328007214 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 875328007215 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 875328007216 NAD binding site [chemical binding]; other site 875328007217 ligand binding site [chemical binding]; other site 875328007218 catalytic site [active] 875328007219 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 875328007220 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 875328007221 Transcriptional regulators [Transcription]; Region: GntR; COG1802 875328007222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328007223 DNA-binding site [nucleotide binding]; DNA binding site 875328007224 FCD domain; Region: FCD; pfam07729 875328007225 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 875328007226 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328007227 Bacterial transcriptional regulator; Region: IclR; pfam01614 875328007228 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328007229 iron-sulfur cluster [ion binding]; other site 875328007230 [2Fe-2S] cluster binding site [ion binding]; other site 875328007231 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 875328007232 beta subunit interface [polypeptide binding]; other site 875328007233 alpha subunit interface [polypeptide binding]; other site 875328007234 active site 875328007235 substrate binding site [chemical binding]; other site 875328007236 Fe binding site [ion binding]; other site 875328007237 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 875328007238 inter-subunit interface; other site 875328007239 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 875328007240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328007241 NAD(P) binding site [chemical binding]; other site 875328007242 active site 875328007243 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 875328007244 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 875328007245 active site 875328007246 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 875328007247 heterodimer interface [polypeptide binding]; other site 875328007248 active site 875328007249 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 875328007250 tetramer interface [polypeptide binding]; other site 875328007251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328007252 TAP-like protein; Region: Abhydrolase_4; pfam08386 875328007253 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 875328007254 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 875328007255 tartrate dehydrogenase; Region: TTC; TIGR02089 875328007256 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 875328007257 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 875328007258 ligand binding site [chemical binding]; other site 875328007259 NAD binding site [chemical binding]; other site 875328007260 dimerization interface [polypeptide binding]; other site 875328007261 catalytic site [active] 875328007262 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 875328007263 putative L-serine binding site [chemical binding]; other site 875328007264 ketol-acid reductoisomerase; Provisional; Region: PRK05479 875328007265 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 875328007266 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 875328007267 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 875328007268 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 875328007269 putative valine binding site [chemical binding]; other site 875328007270 dimer interface [polypeptide binding]; other site 875328007271 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 875328007272 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 875328007273 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 875328007274 PYR/PP interface [polypeptide binding]; other site 875328007275 dimer interface [polypeptide binding]; other site 875328007276 TPP binding site [chemical binding]; other site 875328007277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 875328007278 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 875328007279 TPP-binding site [chemical binding]; other site 875328007280 dimer interface [polypeptide binding]; other site 875328007281 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 875328007282 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 875328007283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007285 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 875328007286 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 875328007287 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 875328007288 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 875328007289 GatB domain; Region: GatB_Yqey; smart00845 875328007290 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 875328007291 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 875328007292 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328007293 6-phosphofructokinase; Provisional; Region: PRK03202 875328007294 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 875328007295 active site 875328007296 ADP/pyrophosphate binding site [chemical binding]; other site 875328007297 dimerization interface [polypeptide binding]; other site 875328007298 allosteric effector site; other site 875328007299 fructose-1,6-bisphosphate binding site; other site 875328007300 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 875328007301 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 875328007302 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 875328007303 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 875328007304 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 875328007305 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 875328007306 nucleotide binding pocket [chemical binding]; other site 875328007307 K-X-D-G motif; other site 875328007308 catalytic site [active] 875328007309 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 875328007310 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 875328007311 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 875328007312 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 875328007313 Dimer interface [polypeptide binding]; other site 875328007314 Protein of unknown function (DUF419); Region: DUF419; pfam04237 875328007315 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 875328007316 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328007317 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 875328007318 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 875328007319 Ligand Binding Site [chemical binding]; other site 875328007320 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 875328007321 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 875328007322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328007323 catalytic residue [active] 875328007324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328007325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328007326 putative acyl-acceptor binding pocket; other site 875328007327 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 875328007328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328007329 classical (c) SDRs; Region: SDR_c; cd05233 875328007330 NAD(P) binding site [chemical binding]; other site 875328007331 active site 875328007332 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 875328007333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328007334 NAD(P) binding site [chemical binding]; other site 875328007335 active site 875328007336 AAA ATPase domain; Region: AAA_16; pfam13191 875328007337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328007338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328007339 DNA binding residues [nucleotide binding] 875328007340 dimerization interface [polypeptide binding]; other site 875328007341 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 875328007342 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 875328007343 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 875328007344 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 875328007345 Ligand binding site [chemical binding]; other site 875328007346 Electron transfer flavoprotein domain; Region: ETF; pfam01012 875328007347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007348 S-adenosylmethionine binding site [chemical binding]; other site 875328007349 Uncharacterized conserved protein [Function unknown]; Region: COG1543 875328007350 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 875328007351 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 875328007352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328007353 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328007354 MMPL family; Region: MMPL; pfam03176 875328007355 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 875328007356 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328007357 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328007358 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 875328007359 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 875328007360 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 875328007361 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 875328007362 trimer interface [polypeptide binding]; other site 875328007363 active site 875328007364 substrate binding site [chemical binding]; other site 875328007365 CoA binding site [chemical binding]; other site 875328007366 FOG: WD40-like repeat [Function unknown]; Region: COG1520 875328007367 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 875328007368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007370 S-adenosylmethionine binding site [chemical binding]; other site 875328007371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328007372 catalytic core [active] 875328007373 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328007374 catalytic core [active] 875328007375 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328007376 catalytic core [active] 875328007377 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328007378 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328007379 substrate binding site [chemical binding]; other site 875328007380 oxyanion hole (OAH) forming residues; other site 875328007381 trimer interface [polypeptide binding]; other site 875328007382 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 875328007383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328007384 Walker A/P-loop; other site 875328007385 ATP binding site [chemical binding]; other site 875328007386 Q-loop/lid; other site 875328007387 ABC transporter signature motif; other site 875328007388 Walker B; other site 875328007389 D-loop; other site 875328007390 H-loop/switch region; other site 875328007391 PE-PPE domain; Region: PE-PPE; pfam08237 875328007392 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 875328007393 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 875328007394 phosphoserine phosphatase SerB; Region: serB; TIGR00338 875328007395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328007396 motif II; other site 875328007397 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 875328007398 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 875328007399 D-pathway; other site 875328007400 Putative ubiquinol binding site [chemical binding]; other site 875328007401 Low-spin heme (heme b) binding site [chemical binding]; other site 875328007402 Putative water exit pathway; other site 875328007403 Binuclear center (heme o3/CuB) [ion binding]; other site 875328007404 K-pathway; other site 875328007405 Putative proton exit pathway; other site 875328007406 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 875328007407 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 875328007408 siderophore binding site; other site 875328007409 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 875328007410 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 875328007411 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328007412 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 875328007413 cyclase homology domain; Region: CHD; cd07302 875328007414 nucleotidyl binding site; other site 875328007415 metal binding site [ion binding]; metal-binding site 875328007416 dimer interface [polypeptide binding]; other site 875328007417 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 875328007418 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 875328007419 putative NAD(P) binding site [chemical binding]; other site 875328007420 putative substrate binding site [chemical binding]; other site 875328007421 catalytic Zn binding site [ion binding]; other site 875328007422 structural Zn binding site [ion binding]; other site 875328007423 dimer interface [polypeptide binding]; other site 875328007424 DoxX-like family; Region: DoxX_2; pfam13564 875328007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328007426 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 875328007427 putative substrate translocation pore; other site 875328007428 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 875328007429 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 875328007430 dimer interface [polypeptide binding]; other site 875328007431 putative radical transfer pathway; other site 875328007432 diiron center [ion binding]; other site 875328007433 tyrosyl radical; other site 875328007434 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328007435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328007436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007438 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 875328007439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 875328007440 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 875328007441 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 875328007442 Class I ribonucleotide reductase; Region: RNR_I; cd01679 875328007443 active site 875328007444 dimer interface [polypeptide binding]; other site 875328007445 catalytic residues [active] 875328007446 effector binding site; other site 875328007447 R2 peptide binding site; other site 875328007448 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 875328007449 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 875328007450 catalytic residues [active] 875328007451 Predicted flavoprotein [General function prediction only]; Region: COG0431 875328007452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 875328007453 short chain dehydrogenase; Provisional; Region: PRK07832 875328007454 classical (c) SDRs; Region: SDR_c; cd05233 875328007455 NAD(P) binding site [chemical binding]; other site 875328007456 active site 875328007457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007459 Cytochrome P450; Region: p450; cl12078 875328007460 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328007461 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328007462 Cytochrome P450; Region: p450; cl12078 875328007463 2-isopropylmalate synthase; Validated; Region: PRK03739 875328007464 pyruvate dehydrogenase; Provisional; Region: PRK09124 875328007465 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 875328007466 PYR/PP interface [polypeptide binding]; other site 875328007467 tetramer interface [polypeptide binding]; other site 875328007468 dimer interface [polypeptide binding]; other site 875328007469 TPP binding site [chemical binding]; other site 875328007470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 875328007471 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 875328007472 TPP-binding site [chemical binding]; other site 875328007473 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328007474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007478 active site 875328007479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328007480 NAD(P) binding site [chemical binding]; other site 875328007481 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 875328007482 active site 875328007483 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 875328007484 Carbon starvation protein CstA; Region: CstA; pfam02554 875328007485 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 875328007486 Protein of unknown function (DUF466); Region: DUF466; cl01082 875328007487 ABC1 family; Region: ABC1; pfam03109 875328007488 Phosphotransferase enzyme family; Region: APH; pfam01636 875328007489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 875328007490 active site 875328007491 ATP binding site [chemical binding]; other site 875328007492 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 875328007493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 875328007494 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 875328007495 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328007496 Cytochrome P450; Region: p450; cl12078 875328007497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328007498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328007499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 875328007500 DNA-binding site [nucleotide binding]; DNA binding site 875328007501 FCD domain; Region: FCD; pfam07729 875328007502 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 875328007503 intersubunit interface [polypeptide binding]; other site 875328007504 active site 875328007505 Zn2+ binding site [ion binding]; other site 875328007506 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328007507 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 875328007508 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 875328007509 dimerization interface [polypeptide binding]; other site 875328007510 NAD binding site [chemical binding]; other site 875328007511 ligand binding site [chemical binding]; other site 875328007512 catalytic site [active] 875328007513 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 875328007514 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 875328007515 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 875328007516 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 875328007517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328007518 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 875328007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328007520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 875328007521 putative substrate translocation pore; other site 875328007522 Protein of unknown function, DUF488; Region: DUF488; cl01246 875328007523 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328007524 PPE family; Region: PPE; pfam00823 875328007525 RDD family; Region: RDD; pfam06271 875328007526 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 875328007527 phosphopeptide binding site; other site 875328007528 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 875328007529 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328007530 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 875328007531 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328007532 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328007533 von Willebrand factor type A domain; Region: VWA_2; pfam13519 875328007534 metal ion-dependent adhesion site (MIDAS); other site 875328007535 Transposase [DNA replication, recombination, and repair]; Region: COG5421 875328007536 von Willebrand factor type A domain; Region: VWA_2; pfam13519 875328007537 metal ion-dependent adhesion site (MIDAS); other site 875328007538 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 875328007539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 875328007540 substrate binding site [chemical binding]; other site 875328007541 activation loop (A-loop); other site 875328007542 Protein phosphatase 2C; Region: PP2C_2; pfam13672 875328007543 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 875328007544 metal ion-dependent adhesion site (MIDAS); other site 875328007545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328007546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328007547 active site 875328007548 phosphorylation site [posttranslational modification] 875328007549 intermolecular recognition site; other site 875328007550 dimerization interface [polypeptide binding]; other site 875328007551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 875328007552 DNA binding residues [nucleotide binding] 875328007553 dimerization interface [polypeptide binding]; other site 875328007554 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328007555 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 875328007556 SmpB-tmRNA interface; other site 875328007557 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 875328007558 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 875328007559 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 875328007560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328007561 Walker A/P-loop; other site 875328007562 ATP binding site [chemical binding]; other site 875328007563 Q-loop/lid; other site 875328007564 ABC transporter signature motif; other site 875328007565 Walker B; other site 875328007566 D-loop; other site 875328007567 H-loop/switch region; other site 875328007568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 875328007569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 875328007570 peptide chain release factor 2; Validated; Region: prfB; PRK00578 875328007571 This domain is found in peptide chain release factors; Region: PCRF; smart00937 875328007572 RF-1 domain; Region: RF-1; pfam00472 875328007573 ferredoxin-NADP+ reductase; Region: PLN02852 875328007574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328007575 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 875328007576 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 875328007577 active site 875328007578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007580 active site 875328007581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007583 active site 875328007584 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 875328007585 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 875328007586 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328007587 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328007588 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 875328007589 active site 875328007590 catalytic residues [active] 875328007591 metal binding site [ion binding]; metal-binding site 875328007592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007595 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328007596 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328007597 active site 875328007598 Phosphotransferase enzyme family; Region: APH; pfam01636 875328007599 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328007600 putative active site [active] 875328007601 putative substrate binding site [chemical binding]; other site 875328007602 ATP binding site [chemical binding]; other site 875328007603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 875328007604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328007605 active site 875328007606 phosphorylation site [posttranslational modification] 875328007607 intermolecular recognition site; other site 875328007608 dimerization interface [polypeptide binding]; other site 875328007609 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 875328007610 NADH dehydrogenase subunit B; Validated; Region: PRK06411 875328007611 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 875328007612 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 875328007613 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 875328007614 NADH dehydrogenase subunit D; Validated; Region: PRK06075 875328007615 NADH dehydrogenase subunit E; Validated; Region: PRK07539 875328007616 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 875328007617 putative dimer interface [polypeptide binding]; other site 875328007618 [2Fe-2S] cluster binding site [ion binding]; other site 875328007619 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 875328007620 SLBB domain; Region: SLBB; pfam10531 875328007621 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 875328007622 NADH dehydrogenase subunit G; Validated; Region: PRK07860 875328007623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328007624 catalytic loop [active] 875328007625 iron binding site [ion binding]; other site 875328007626 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 875328007627 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328007628 molybdopterin cofactor binding site; other site 875328007629 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328007630 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 875328007631 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 875328007632 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 875328007633 4Fe-4S binding domain; Region: Fer4; pfam00037 875328007634 4Fe-4S binding domain; Region: Fer4; pfam00037 875328007635 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 875328007636 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 875328007637 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 875328007638 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 875328007639 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 875328007640 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328007641 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 875328007642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328007643 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 875328007644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 875328007645 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 875328007646 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328007647 FAD binding pocket [chemical binding]; other site 875328007648 FAD binding motif [chemical binding]; other site 875328007649 phosphate binding motif [ion binding]; other site 875328007650 beta-alpha-beta structure motif; other site 875328007651 NAD binding pocket [chemical binding]; other site 875328007652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328007653 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 875328007654 catalytic loop [active] 875328007655 iron binding site [ion binding]; other site 875328007656 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 875328007657 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 875328007658 putative di-iron ligands [ion binding]; other site 875328007659 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 875328007660 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 875328007661 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 875328007662 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 875328007663 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 875328007664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007666 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328007667 putative active site [active] 875328007668 putative substrate binding site [chemical binding]; other site 875328007669 ATP binding site [chemical binding]; other site 875328007670 Phosphotransferase enzyme family; Region: APH; pfam01636 875328007671 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 875328007672 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328007673 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328007674 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328007675 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 875328007676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 875328007677 NAD(P) binding site [chemical binding]; other site 875328007678 Cutinase; Region: Cutinase; pfam01083 875328007679 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328007680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328007681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007683 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 875328007684 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 875328007685 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 875328007686 putative active site [active] 875328007687 Permease; Region: Permease; pfam02405 875328007688 Permease; Region: Permease; pfam02405 875328007689 mce related protein; Region: MCE; pfam02470 875328007690 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328007691 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328007692 mce related protein; Region: MCE; pfam02470 875328007693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328007694 mce related protein; Region: MCE; pfam02470 875328007695 mce related protein; Region: MCE; pfam02470 875328007696 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328007697 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328007698 mce related protein; Region: MCE; pfam02470 875328007699 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 875328007700 mce related protein; Region: MCE; pfam02470 875328007701 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328007702 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 875328007703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007706 hypothetical protein; Validated; Region: PRK00068 875328007707 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 875328007708 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 875328007709 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 875328007710 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 875328007711 Uncharacterized conserved protein [Function unknown]; Region: COG5282 875328007712 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 875328007713 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 875328007714 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328007715 putative acyl-acceptor binding pocket; other site 875328007716 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 875328007717 ABC1 family; Region: ABC1; pfam03109 875328007718 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 875328007719 active site 875328007720 ATP binding site [chemical binding]; other site 875328007721 Transcription factor WhiB; Region: Whib; pfam02467 875328007722 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 875328007723 Part of AAA domain; Region: AAA_19; pfam13245 875328007724 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 875328007725 Family description; Region: UvrD_C_2; pfam13538 875328007726 HRDC domain; Region: HRDC; pfam00570 875328007727 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 875328007728 catalytic residues [active] 875328007729 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 875328007730 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 875328007731 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 875328007732 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 875328007733 putative NADH binding site [chemical binding]; other site 875328007734 putative active site [active] 875328007735 nudix motif; other site 875328007736 putative metal binding site [ion binding]; other site 875328007737 Ion channel; Region: Ion_trans_2; pfam07885 875328007738 TrkA-N domain; Region: TrkA_N; pfam02254 875328007739 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 875328007740 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 875328007741 Part of AAA domain; Region: AAA_19; pfam13245 875328007742 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 875328007743 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 875328007744 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 875328007745 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 875328007746 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328007747 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328007748 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 875328007749 catalytic site [active] 875328007750 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 875328007751 active site 875328007752 DNA binding site [nucleotide binding] 875328007753 TIGR02569 family protein; Region: TIGR02569_actnb 875328007754 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 875328007755 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 875328007756 ATP binding site [chemical binding]; other site 875328007757 substrate interface [chemical binding]; other site 875328007758 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 875328007759 active site residue [active] 875328007760 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 875328007761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007763 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 875328007764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 875328007765 dinuclear metal binding motif [ion binding]; other site 875328007766 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 875328007767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 875328007768 ATP binding site [chemical binding]; other site 875328007769 Mg++ binding site [ion binding]; other site 875328007770 motif III; other site 875328007771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328007772 nucleotide binding region [chemical binding]; other site 875328007773 ATP-binding site [chemical binding]; other site 875328007774 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 875328007775 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328007776 P-loop; other site 875328007777 Magnesium ion binding site [ion binding]; other site 875328007778 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328007779 Magnesium ion binding site [ion binding]; other site 875328007780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328007781 catalytic core [active] 875328007782 isochorismate synthase DhbC; Validated; Region: PRK06923 875328007783 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 875328007784 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 875328007785 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 875328007786 Transcription factor WhiB; Region: Whib; pfam02467 875328007787 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 875328007788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 875328007789 Histidine kinase; Region: HisKA_2; pfam07568 875328007790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328007791 ATP binding site [chemical binding]; other site 875328007792 Mg2+ binding site [ion binding]; other site 875328007793 G-X-G motif; other site 875328007794 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328007795 carboxyltransferase (CT) interaction site; other site 875328007796 biotinylation site [posttranslational modification]; other site 875328007797 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 875328007798 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 875328007799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328007800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328007801 DNA binding residues [nucleotide binding] 875328007802 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 875328007803 anti sigma factor interaction site; other site 875328007804 regulatory phosphorylation site [posttranslational modification]; other site 875328007805 CsbD-like; Region: CsbD; pfam05532 875328007806 tetracycline repressor protein TetR; Provisional; Region: PRK13756 875328007807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007808 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 875328007809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328007810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328007811 NAD(P) binding site [chemical binding]; other site 875328007812 active site 875328007813 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007815 active site 875328007816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328007817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328007818 active site 875328007819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007821 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 875328007822 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 875328007823 short chain dehydrogenase; Provisional; Region: PRK08278 875328007824 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 875328007825 NAD(P) binding site [chemical binding]; other site 875328007826 homodimer interface [polypeptide binding]; other site 875328007827 active site 875328007828 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 875328007829 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328007830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007831 S-adenosylmethionine binding site [chemical binding]; other site 875328007832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 875328007833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328007834 dimer interface [polypeptide binding]; other site 875328007835 phosphorylation site [posttranslational modification] 875328007836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328007837 ATP binding site [chemical binding]; other site 875328007838 Mg2+ binding site [ion binding]; other site 875328007839 G-X-G motif; other site 875328007840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328007841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328007842 active site 875328007843 phosphorylation site [posttranslational modification] 875328007844 intermolecular recognition site; other site 875328007845 dimerization interface [polypeptide binding]; other site 875328007846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328007847 DNA binding site [nucleotide binding] 875328007848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328007849 PPE family; Region: PPE; pfam00823 875328007850 Short C-terminal domain; Region: SHOCT; pfam09851 875328007851 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328007852 PPE family; Region: PPE; pfam00823 875328007853 Short C-terminal domain; Region: SHOCT; pfam09851 875328007854 Uncharacterized conserved protein [Function unknown]; Region: COG2135 875328007855 Methyltransferase domain; Region: Methyltransf_31; pfam13847 875328007856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328007857 S-adenosylmethionine binding site [chemical binding]; other site 875328007858 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 875328007859 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328007860 PE family; Region: PE; pfam00934 875328007861 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328007862 PPE family; Region: PPE; pfam00823 875328007863 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328007864 PPE family; Region: PPE; pfam00823 875328007865 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328007866 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328007867 active site 875328007868 ATP binding site [chemical binding]; other site 875328007869 substrate binding site [chemical binding]; other site 875328007870 activation loop (A-loop); other site 875328007871 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 875328007872 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 875328007873 hinge; other site 875328007874 active site 875328007875 Predicted GTPases [General function prediction only]; Region: COG1162 875328007876 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 875328007877 GTPase/Zn-binding domain interface [polypeptide binding]; other site 875328007878 GTP/Mg2+ binding site [chemical binding]; other site 875328007879 G4 box; other site 875328007880 G5 box; other site 875328007881 G1 box; other site 875328007882 Switch I region; other site 875328007883 G2 box; other site 875328007884 G3 box; other site 875328007885 Switch II region; other site 875328007886 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 875328007887 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 875328007888 putative di-iron ligands [ion binding]; other site 875328007889 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 875328007890 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328007891 FAD binding pocket [chemical binding]; other site 875328007892 FAD binding motif [chemical binding]; other site 875328007893 phosphate binding motif [ion binding]; other site 875328007894 beta-alpha-beta structure motif; other site 875328007895 NAD binding pocket [chemical binding]; other site 875328007896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328007897 catalytic loop [active] 875328007898 iron binding site [ion binding]; other site 875328007899 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 875328007900 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328007901 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328007902 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 875328007903 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 875328007904 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 875328007905 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 875328007906 30S subunit binding site; other site 875328007907 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 875328007908 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 875328007909 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 875328007910 Binuclear center (active site) [active] 875328007911 K-pathway; other site 875328007912 Putative proton exit pathway; other site 875328007913 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 875328007914 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 875328007915 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 875328007916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 875328007917 classical (c) SDRs; Region: SDR_c; cd05233 875328007918 NAD(P) binding site [chemical binding]; other site 875328007919 active site 875328007920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328007921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328007922 active site 875328007923 phosphorylation site [posttranslational modification] 875328007924 intermolecular recognition site; other site 875328007925 dimerization interface [polypeptide binding]; other site 875328007926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328007927 DNA binding residues [nucleotide binding] 875328007928 dimerization interface [polypeptide binding]; other site 875328007929 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 875328007930 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 875328007931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 875328007932 Histidine kinase; Region: HisKA_3; pfam07730 875328007933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328007934 ATP binding site [chemical binding]; other site 875328007935 G-X-G motif; other site 875328007936 hypothetical protein; Provisional; Region: PRK07877 875328007937 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 875328007938 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 875328007939 ligand binding site [chemical binding]; other site 875328007940 flexible hinge region; other site 875328007941 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 875328007942 CheB methylesterase; Region: CheB_methylest; pfam01339 875328007943 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328007944 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328007945 lipoprotein LpqB; Provisional; Region: PRK13616 875328007946 Sporulation and spore germination; Region: Germane; pfam10646 875328007947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 875328007948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328007949 dimerization interface [polypeptide binding]; other site 875328007950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328007951 dimer interface [polypeptide binding]; other site 875328007952 phosphorylation site [posttranslational modification] 875328007953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328007954 ATP binding site [chemical binding]; other site 875328007955 Mg2+ binding site [ion binding]; other site 875328007956 G-X-G motif; other site 875328007957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328007959 active site 875328007960 phosphorylation site [posttranslational modification] 875328007961 intermolecular recognition site; other site 875328007962 dimerization interface [polypeptide binding]; other site 875328007963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328007964 DNA binding site [nucleotide binding] 875328007965 thymidylate kinase; Validated; Region: PRK07933 875328007966 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 875328007967 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 875328007968 homotetramer interface [polypeptide binding]; other site 875328007969 ligand binding site [chemical binding]; other site 875328007970 catalytic site [active] 875328007971 NAD binding site [chemical binding]; other site 875328007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328007974 Rubredoxin [Energy production and conversion]; Region: COG1773 875328007975 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 875328007976 iron binding site [ion binding]; other site 875328007977 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 875328007978 Fatty acid desaturase; Region: FA_desaturase; pfam00487 875328007979 Di-iron ligands [ion binding]; other site 875328007980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328007981 dimerization interface [polypeptide binding]; other site 875328007982 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328007983 cyclase homology domain; Region: CHD; cd07302 875328007984 nucleotidyl binding site; other site 875328007985 metal binding site [ion binding]; metal-binding site 875328007986 dimer interface [polypeptide binding]; other site 875328007987 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328007988 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 875328007989 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328007990 CoenzymeA binding site [chemical binding]; other site 875328007991 subunit interaction site [polypeptide binding]; other site 875328007992 PHB binding site; other site 875328007993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328007994 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 875328007995 Methyltransferase domain; Region: Methyltransf_11; pfam08241 875328007996 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 875328007997 Protein of unknown function, DUF608; Region: DUF608; pfam04685 875328007998 Methyltransferase domain; Region: Methyltransf_24; pfam13578 875328007999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328008000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328008001 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 875328008002 Cation efflux family; Region: Cation_efflux; pfam01545 875328008003 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 875328008004 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 875328008005 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 875328008006 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 875328008007 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 875328008008 active site 875328008009 substrate binding site [chemical binding]; other site 875328008010 metal binding site [ion binding]; metal-binding site 875328008011 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 875328008012 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 875328008013 Transcription factor WhiB; Region: Whib; pfam02467 875328008014 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 875328008015 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 875328008016 phosphate binding site [ion binding]; other site 875328008017 dimer interface [polypeptide binding]; other site 875328008018 substrate binding site [chemical binding]; other site 875328008019 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 875328008020 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 875328008021 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 875328008022 putative FMN binding site [chemical binding]; other site 875328008023 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 875328008024 nudix motif; other site 875328008025 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 875328008026 oligomeric interface; other site 875328008027 putative active site [active] 875328008028 homodimer interface [polypeptide binding]; other site 875328008029 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 875328008030 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 875328008031 active site 875328008032 Substrate binding site; other site 875328008033 Mg++ binding site; other site 875328008034 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 875328008035 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 875328008036 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 875328008037 Probable Catalytic site; other site 875328008038 metal-binding site 875328008039 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 875328008040 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 875328008041 NADP binding site [chemical binding]; other site 875328008042 active site 875328008043 putative substrate binding site [chemical binding]; other site 875328008044 Transcriptional regulator [Transcription]; Region: LytR; COG1316 875328008045 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 875328008046 TIGR03089 family protein; Region: TIGR03089 875328008047 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 875328008048 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 875328008049 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328008050 Soluble P-type ATPase [General function prediction only]; Region: COG4087 875328008051 Cation efflux family; Region: Cation_efflux; cl00316 875328008052 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328008053 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328008054 active site 875328008055 ATP binding site [chemical binding]; other site 875328008056 substrate binding site [chemical binding]; other site 875328008057 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 875328008058 substrate binding site [chemical binding]; other site 875328008059 activation loop (A-loop); other site 875328008060 activation loop (A-loop); other site 875328008061 Uncharacterized conserved protein [Function unknown]; Region: COG3391 875328008062 NHL repeat; Region: NHL; pfam01436 875328008063 NHL repeat; Region: NHL; pfam01436 875328008064 NHL repeat; Region: NHL; pfam01436 875328008065 NHL repeat; Region: NHL; pfam01436 875328008066 PBP superfamily domain; Region: PBP_like_2; cl17296 875328008067 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328008068 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328008069 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 875328008070 propionate/acetate kinase; Provisional; Region: PRK12379 875328008071 phosphate acetyltransferase; Reviewed; Region: PRK05632 875328008072 DRTGG domain; Region: DRTGG; pfam07085 875328008073 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 875328008074 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 875328008075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328008076 catalytic residue [active] 875328008077 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 875328008078 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 875328008079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008080 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 875328008081 FAD binding site [chemical binding]; other site 875328008082 homotetramer interface [polypeptide binding]; other site 875328008083 substrate binding pocket [chemical binding]; other site 875328008084 catalytic base [active] 875328008085 AIR carboxylase; Region: AIRC; pfam00731 875328008086 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 875328008087 ATP-grasp domain; Region: ATP-grasp; pfam02222 875328008088 Predicted membrane protein [Function unknown]; Region: COG2246 875328008089 GtrA-like protein; Region: GtrA; pfam04138 875328008090 Bacterial PH domain; Region: DUF304; pfam03703 875328008091 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 875328008092 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 875328008093 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 875328008094 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328008095 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328008096 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 875328008097 nucleotide binding site [chemical binding]; other site 875328008098 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328008099 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 875328008100 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328008101 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 875328008102 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 875328008103 putative active site [active] 875328008104 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 875328008105 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 875328008106 active site residue [active] 875328008107 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 875328008108 active site residue [active] 875328008109 Fe-S metabolism associated domain; Region: SufE; cl00951 875328008110 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 875328008111 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328008112 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 875328008113 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 875328008114 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328008115 carboxyltransferase (CT) interaction site; other site 875328008116 biotinylation site [posttranslational modification]; other site 875328008117 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328008118 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 875328008119 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328008120 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 875328008121 anti sigma factor interaction site; other site 875328008122 regulatory phosphorylation site [posttranslational modification]; other site 875328008123 hydroperoxidase II; Provisional; Region: katE; PRK11249 875328008124 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 875328008125 tetramer interface [polypeptide binding]; other site 875328008126 heme binding pocket [chemical binding]; other site 875328008127 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 875328008128 domain interactions; other site 875328008129 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 875328008130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328008131 motif II; other site 875328008132 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 875328008133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 875328008134 ChaB; Region: ChaB; pfam06150 875328008135 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 875328008136 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328008137 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328008138 active site 875328008139 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 875328008140 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 875328008141 putative NAD(P) binding site [chemical binding]; other site 875328008142 active site 875328008143 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 875328008144 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 875328008145 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 875328008146 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 875328008147 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 875328008148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328008149 ATP binding site [chemical binding]; other site 875328008150 Mg2+ binding site [ion binding]; other site 875328008151 G-X-G motif; other site 875328008152 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 875328008153 anti sigma factor interaction site; other site 875328008154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 875328008155 HSP70 interaction site [polypeptide binding]; other site 875328008156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 875328008157 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 875328008158 putative dimer interface [polypeptide binding]; other site 875328008159 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 875328008160 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 875328008161 DNA binding residues [nucleotide binding] 875328008162 putative dimer interface [polypeptide binding]; other site 875328008163 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 875328008164 putative methyltransferase; Provisional; Region: PRK14967 875328008165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328008166 S-adenosylmethionine binding site [chemical binding]; other site 875328008167 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 875328008168 thiamine pyrophosphate protein; Provisional; Region: PRK08273 875328008169 PYR/PP interface [polypeptide binding]; other site 875328008170 dimer interface [polypeptide binding]; other site 875328008171 tetramer interface [polypeptide binding]; other site 875328008172 TPP binding site [chemical binding]; other site 875328008173 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 875328008174 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 875328008175 TPP-binding site [chemical binding]; other site 875328008176 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 875328008177 Fe-S cluster binding site [ion binding]; other site 875328008178 active site 875328008179 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 875328008180 PAS fold; Region: PAS_3; pfam08447 875328008181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 875328008182 putative active site [active] 875328008183 heme pocket [chemical binding]; other site 875328008184 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 875328008185 CheB methylesterase; Region: CheB_methylest; pfam01339 875328008186 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 875328008187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 875328008188 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 875328008189 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 875328008190 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 875328008191 putative ADP-binding pocket [chemical binding]; other site 875328008192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 875328008193 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 875328008194 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 875328008195 anti sigma factor interaction site; other site 875328008196 regulatory phosphorylation site [posttranslational modification]; other site 875328008197 metabolite-proton symporter; Region: 2A0106; TIGR00883 875328008198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328008199 putative substrate translocation pore; other site 875328008200 Cutinase; Region: Cutinase; pfam01083 875328008201 Putative esterase; Region: Esterase; pfam00756 875328008202 Hemerythrin-like domain; Region: Hr-like; cd12108 875328008203 Fe binding site [ion binding]; other site 875328008204 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 875328008205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328008206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328008207 catalytic residue [active] 875328008208 intracellular protease, PfpI family; Region: PfpI; TIGR01382 875328008209 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 875328008210 proposed catalytic triad [active] 875328008211 conserved cys residue [active] 875328008212 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 875328008213 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 875328008214 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 875328008215 Moco binding site; other site 875328008216 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 875328008217 metal coordination site [ion binding]; other site 875328008218 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 875328008219 Cutinase; Region: Cutinase; pfam01083 875328008220 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 875328008221 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 875328008222 putative active site pocket [active] 875328008223 putative metal binding site [ion binding]; other site 875328008224 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 875328008225 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 875328008226 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 875328008227 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 875328008228 NAD binding site [chemical binding]; other site 875328008229 catalytic Zn binding site [ion binding]; other site 875328008230 structural Zn binding site [ion binding]; other site 875328008231 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 875328008232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328008233 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328008234 iron-sulfur cluster [ion binding]; other site 875328008235 [2Fe-2S] cluster binding site [ion binding]; other site 875328008236 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 875328008237 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 875328008238 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 875328008239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328008240 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 875328008241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 875328008242 DNA binding residues [nucleotide binding] 875328008243 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 875328008244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 875328008245 CsbD-like; Region: CsbD; cl17424 875328008246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328008247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328008248 DNA binding site [nucleotide binding] 875328008249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328008250 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 875328008251 ATP binding site [chemical binding]; other site 875328008252 putative Mg++ binding site [ion binding]; other site 875328008253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328008254 nucleotide binding region [chemical binding]; other site 875328008255 ATP-binding site [chemical binding]; other site 875328008256 DEAD/H associated; Region: DEAD_assoc; pfam08494 875328008257 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 875328008258 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 875328008259 putative DNA binding site [nucleotide binding]; other site 875328008260 catalytic residue [active] 875328008261 putative H2TH interface [polypeptide binding]; other site 875328008262 putative catalytic residues [active] 875328008263 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 875328008264 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 875328008265 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 875328008266 active site 875328008267 catalytic triad [active] 875328008268 dimer interface [polypeptide binding]; other site 875328008269 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328008270 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 875328008271 active site 875328008272 Integrase core domain; Region: rve; pfam00665 875328008273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328008274 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328008275 active site 875328008276 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 875328008277 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 875328008278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328008279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328008280 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 875328008281 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 875328008282 putative active site pocket [active] 875328008283 dimerization interface [polypeptide binding]; other site 875328008284 putative catalytic residue [active] 875328008285 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 875328008286 putative active site [active] 875328008287 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 875328008288 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 875328008289 metal binding site [ion binding]; metal-binding site 875328008290 putative dimer interface [polypeptide binding]; other site 875328008291 purine nucleoside phosphorylase; Provisional; Region: PRK08202 875328008292 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 875328008293 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 875328008294 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 875328008295 active site 875328008296 substrate binding site [chemical binding]; other site 875328008297 metal binding site [ion binding]; metal-binding site 875328008298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328008299 active site 875328008300 PE-PPE domain; Region: PE-PPE; pfam08237 875328008301 PE-PPE domain; Region: PE-PPE; pfam08237 875328008302 LGFP repeat; Region: LGFP; pfam08310 875328008303 LGFP repeat; Region: LGFP; pfam08310 875328008304 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 875328008305 adenosine deaminase; Provisional; Region: PRK09358 875328008306 active site 875328008307 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 875328008308 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 875328008309 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 875328008310 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 875328008311 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 875328008312 active site 875328008313 catalytic motif [active] 875328008314 Zn binding site [ion binding]; other site 875328008315 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 875328008316 putative Iron-sulfur protein interface [polypeptide binding]; other site 875328008317 putative proximal heme binding site [chemical binding]; other site 875328008318 putative SdhD-like interface [polypeptide binding]; other site 875328008319 putative distal heme binding site [chemical binding]; other site 875328008320 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 875328008321 putative Iron-sulfur protein interface [polypeptide binding]; other site 875328008322 putative proximal heme binding site [chemical binding]; other site 875328008323 putative SdhC-like subunit interface [polypeptide binding]; other site 875328008324 putative distal heme binding site [chemical binding]; other site 875328008325 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 875328008326 L-aspartate oxidase; Provisional; Region: PRK06175 875328008327 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 875328008328 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 875328008329 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 875328008330 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 875328008331 Uncharacterized conserved protein [Function unknown]; Region: COG2128 875328008332 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 875328008333 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 875328008334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328008335 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 875328008336 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 875328008337 Strictosidine synthase; Region: Str_synth; pfam03088 875328008338 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 875328008339 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 875328008340 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 875328008341 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 875328008342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328008343 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 875328008344 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328008345 active site 875328008346 Predicted acetyltransferase [General function prediction only]; Region: COG2388 875328008347 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 875328008348 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 875328008349 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 875328008350 active site 875328008351 HIGH motif; other site 875328008352 dimer interface [polypeptide binding]; other site 875328008353 KMSKS motif; other site 875328008354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328008355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328008356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008357 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328008358 substrate binding site [chemical binding]; other site 875328008359 oxyanion hole (OAH) forming residues; other site 875328008360 trimer interface [polypeptide binding]; other site 875328008361 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 875328008362 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 875328008363 Precorrin-8X methylmutase; Region: CbiC; pfam02570 875328008364 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 875328008365 active site 875328008366 SAM binding site [chemical binding]; other site 875328008367 homodimer interface [polypeptide binding]; other site 875328008368 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 875328008369 active site 875328008370 SAM binding site [chemical binding]; other site 875328008371 homodimer interface [polypeptide binding]; other site 875328008372 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 875328008373 active site 875328008374 homodimer interface [polypeptide binding]; other site 875328008375 SAM binding site [chemical binding]; other site 875328008376 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 875328008377 active site 875328008378 putative homodimer interface [polypeptide binding]; other site 875328008379 SAM binding site [chemical binding]; other site 875328008380 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 875328008381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328008382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 875328008383 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 875328008384 metal ion-dependent adhesion site (MIDAS); other site 875328008385 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 875328008386 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 875328008387 homodimer interface [polypeptide binding]; other site 875328008388 Walker A motif; other site 875328008389 ATP binding site [chemical binding]; other site 875328008390 hydroxycobalamin binding site [chemical binding]; other site 875328008391 Walker B motif; other site 875328008392 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 875328008393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328008394 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 875328008395 catalytic triad [active] 875328008396 hypothetical protein; Provisional; Region: PRK07908 875328008397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328008398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328008399 homodimer interface [polypeptide binding]; other site 875328008400 catalytic residue [active] 875328008401 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 875328008402 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 875328008403 Domain of unknown function (DUF385); Region: DUF385; pfam04075 875328008404 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 875328008405 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 875328008406 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 875328008407 cobyric acid synthase; Provisional; Region: PRK00784 875328008408 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 875328008409 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 875328008410 catalytic triad [active] 875328008411 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 875328008412 active site 875328008413 SAM binding site [chemical binding]; other site 875328008414 homodimer interface [polypeptide binding]; other site 875328008415 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 875328008416 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 875328008417 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 875328008418 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 875328008419 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 875328008420 intersubunit interface [polypeptide binding]; other site 875328008421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 875328008422 dimer interface [polypeptide binding]; other site 875328008423 putative PBP binding regions; other site 875328008424 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 875328008425 ABC-ATPase subunit interface; other site 875328008426 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 875328008427 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 875328008428 Walker A/P-loop; other site 875328008429 ATP binding site [chemical binding]; other site 875328008430 Q-loop/lid; other site 875328008431 ABC transporter signature motif; other site 875328008432 Walker B; other site 875328008433 D-loop; other site 875328008434 H-loop/switch region; other site 875328008435 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 875328008436 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 875328008437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328008438 PPE family; Region: PPE; pfam00823 875328008439 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328008440 PPE family; Region: PPE; pfam00823 875328008441 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 875328008442 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 875328008443 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 875328008444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 875328008445 homodimer interface [polypeptide binding]; other site 875328008446 substrate-cofactor binding pocket; other site 875328008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328008448 catalytic residue [active] 875328008449 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 875328008450 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 875328008451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328008452 S-adenosylmethionine binding site [chemical binding]; other site 875328008453 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328008454 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 875328008455 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 875328008456 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 875328008457 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 875328008458 homodimer interface [polypeptide binding]; other site 875328008459 NADP binding site [chemical binding]; other site 875328008460 substrate binding site [chemical binding]; other site 875328008461 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 875328008462 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 875328008463 active site 875328008464 FMN binding site [chemical binding]; other site 875328008465 substrate binding site [chemical binding]; other site 875328008466 putative catalytic residue [active] 875328008467 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 875328008468 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 875328008469 phosphopeptide binding site; other site 875328008470 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 875328008471 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 875328008472 phosphopeptide binding site; other site 875328008473 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 875328008474 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 875328008475 Walker A/P-loop; other site 875328008476 ATP binding site [chemical binding]; other site 875328008477 Q-loop/lid; other site 875328008478 ABC transporter signature motif; other site 875328008479 Walker B; other site 875328008480 D-loop; other site 875328008481 H-loop/switch region; other site 875328008482 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 875328008483 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 875328008484 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 875328008485 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 875328008486 G2 box; other site 875328008487 Switch I region; other site 875328008488 G3 box; other site 875328008489 Switch II region; other site 875328008490 GTP/Mg2+ binding site [chemical binding]; other site 875328008491 G4 box; other site 875328008492 G5 box; other site 875328008493 Protein of unknown function (DUF742); Region: DUF742; pfam05331 875328008494 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 875328008495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328008496 ATP binding site [chemical binding]; other site 875328008497 Mg2+ binding site [ion binding]; other site 875328008498 G-X-G motif; other site 875328008499 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 875328008500 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 875328008501 FMN binding site [chemical binding]; other site 875328008502 dimer interface [polypeptide binding]; other site 875328008503 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 875328008504 MOSC domain; Region: MOSC; pfam03473 875328008505 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 875328008506 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 875328008507 active site 875328008508 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 875328008509 generic binding surface II; other site 875328008510 generic binding surface I; other site 875328008511 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328008512 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328008513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 875328008514 Ligand Binding Site [chemical binding]; other site 875328008515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 875328008516 Ligand Binding Site [chemical binding]; other site 875328008517 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 875328008518 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 875328008519 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008520 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328008521 active site 875328008522 enoyl-CoA hydratase; Region: PLN02864 875328008523 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328008524 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 875328008525 dimer interaction site [polypeptide binding]; other site 875328008526 substrate-binding tunnel; other site 875328008527 active site 875328008528 catalytic site [active] 875328008529 substrate binding site [chemical binding]; other site 875328008530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328008531 catalytic core [active] 875328008532 short chain dehydrogenase; Provisional; Region: PRK07201 875328008533 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 875328008534 putative NAD(P) binding site [chemical binding]; other site 875328008535 active site 875328008536 putative substrate binding site [chemical binding]; other site 875328008537 classical (c) SDRs; Region: SDR_c; cd05233 875328008538 NAD(P) binding site [chemical binding]; other site 875328008539 active site 875328008540 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 875328008541 active site 875328008542 Y-family of DNA polymerases; Region: PolY; cl12025 875328008543 active site 875328008544 DNA binding site [nucleotide binding] 875328008545 GMP synthase; Reviewed; Region: guaA; PRK00074 875328008546 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 875328008547 AMP/PPi binding site [chemical binding]; other site 875328008548 candidate oxyanion hole; other site 875328008549 catalytic triad [active] 875328008550 potential glutamine specificity residues [chemical binding]; other site 875328008551 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 875328008552 ATP Binding subdomain [chemical binding]; other site 875328008553 Ligand Binding sites [chemical binding]; other site 875328008554 Dimerization subdomain; other site 875328008555 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 875328008556 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 875328008557 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 875328008558 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 875328008559 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 875328008560 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 875328008561 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 875328008562 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 875328008563 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 875328008564 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328008565 phosphate binding site [ion binding]; other site 875328008566 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 875328008567 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328008568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 875328008569 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 875328008570 active site 875328008571 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 875328008572 Transcription factor WhiB; Region: Whib; pfam02467 875328008573 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328008574 PE-PPE domain; Region: PE-PPE; pfam08237 875328008575 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 875328008576 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328008577 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 875328008578 PE-PPE domain; Region: PE-PPE; pfam08237 875328008579 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 875328008580 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 875328008581 ring oligomerisation interface [polypeptide binding]; other site 875328008582 ATP/Mg binding site [chemical binding]; other site 875328008583 stacking interactions; other site 875328008584 hinge regions; other site 875328008585 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 875328008586 oligomerisation interface [polypeptide binding]; other site 875328008587 mobile loop; other site 875328008588 roof hairpin; other site 875328008589 UGMP family protein; Validated; Region: PRK09604 875328008590 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 875328008591 Glycoprotease family; Region: Peptidase_M22; pfam00814 875328008592 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 875328008593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328008594 Coenzyme A binding pocket [chemical binding]; other site 875328008595 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 875328008596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328008597 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328008598 alanine racemase; Reviewed; Region: alr; PRK00053 875328008599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 875328008600 active site 875328008601 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 875328008602 dimer interface [polypeptide binding]; other site 875328008603 substrate binding site [chemical binding]; other site 875328008604 catalytic residues [active] 875328008605 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 875328008606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328008607 catalytic residue [active] 875328008608 Uncharacterized conserved protein [Function unknown]; Region: COG0062 875328008609 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 875328008610 putative substrate binding site [chemical binding]; other site 875328008611 putative ATP binding site [chemical binding]; other site 875328008612 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328008613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328008614 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328008615 classical (c) SDRs; Region: SDR_c; cd05233 875328008616 NAD(P) binding site [chemical binding]; other site 875328008617 active site 875328008618 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 875328008619 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 875328008620 glutaminase active site [active] 875328008621 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 875328008622 dimer interface [polypeptide binding]; other site 875328008623 active site 875328008624 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 875328008625 dimer interface [polypeptide binding]; other site 875328008626 active site 875328008627 acyl-CoA synthetase; Validated; Region: PRK05850 875328008628 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328008629 acyl-activating enzyme (AAE) consensus motif; other site 875328008630 active site 875328008631 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 875328008632 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328008633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 875328008634 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328008635 acyl-activating enzyme (AAE) consensus motif; other site 875328008636 active site 875328008637 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 875328008638 putative active site [active] 875328008639 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 875328008640 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 875328008641 active site 875328008642 substrate binding site [chemical binding]; other site 875328008643 metal binding site [ion binding]; metal-binding site 875328008644 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 875328008645 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 875328008646 23S rRNA interface [nucleotide binding]; other site 875328008647 L3 interface [polypeptide binding]; other site 875328008648 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328008649 Proteins of 100 residues with WXG; Region: WXG100; cl02005 875328008650 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 875328008651 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 875328008652 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328008653 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 875328008654 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328008655 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 875328008656 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 875328008657 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 875328008658 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 875328008659 active site 875328008660 catalytic residues [active] 875328008661 Cutinase; Region: Cutinase; pfam01083 875328008662 Cutinase; Region: Cutinase; pfam01083 875328008663 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 875328008664 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 875328008665 active site 875328008666 dimerization interface 3.5A [polypeptide binding]; other site 875328008667 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 875328008668 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 875328008669 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 875328008670 alphaNTD - beta interaction site [polypeptide binding]; other site 875328008671 alphaNTD homodimer interface [polypeptide binding]; other site 875328008672 alphaNTD - beta' interaction site [polypeptide binding]; other site 875328008673 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 875328008674 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 875328008675 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 875328008676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 875328008677 RNA binding surface [nucleotide binding]; other site 875328008678 30S ribosomal protein S11; Validated; Region: PRK05309 875328008679 30S ribosomal protein S13; Region: bact_S13; TIGR03631 875328008680 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 875328008681 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 875328008682 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 875328008683 rRNA binding site [nucleotide binding]; other site 875328008684 predicted 30S ribosome binding site; other site 875328008685 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 875328008686 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 875328008687 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 875328008688 NAD binding site [chemical binding]; other site 875328008689 substrate binding site [chemical binding]; other site 875328008690 homodimer interface [polypeptide binding]; other site 875328008691 active site 875328008692 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 875328008693 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 875328008694 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 875328008695 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 875328008696 tetrameric interface [polypeptide binding]; other site 875328008697 NAD binding site [chemical binding]; other site 875328008698 catalytic residues [active] 875328008699 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 875328008700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008701 substrate binding pocket [chemical binding]; other site 875328008702 FAD binding site [chemical binding]; other site 875328008703 catalytic base [active] 875328008704 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328008705 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 875328008706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 875328008707 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 875328008708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328008709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328008710 active site 875328008711 phosphorylation site [posttranslational modification] 875328008712 intermolecular recognition site; other site 875328008713 dimerization interface [polypeptide binding]; other site 875328008714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328008715 DNA binding residues [nucleotide binding] 875328008716 dimerization interface [polypeptide binding]; other site 875328008717 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 875328008718 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 875328008719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 875328008720 Histidine kinase; Region: HisKA_3; pfam07730 875328008721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328008722 ATP binding site [chemical binding]; other site 875328008723 Mg2+ binding site [ion binding]; other site 875328008724 G-X-G motif; other site 875328008725 MarR family; Region: MarR; pfam01047 875328008726 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 875328008727 active site 875328008728 adenylate kinase; Reviewed; Region: adk; PRK00279 875328008729 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 875328008730 AMP-binding site [chemical binding]; other site 875328008731 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 875328008732 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 875328008733 SecY translocase; Region: SecY; pfam00344 875328008734 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328008735 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328008736 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 875328008737 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 875328008738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328008739 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328008740 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328008741 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 875328008742 tandem repeat interface [polypeptide binding]; other site 875328008743 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 875328008744 oligomer interface [polypeptide binding]; other site 875328008745 active site residues [active] 875328008746 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 875328008747 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 875328008748 oligomer interface [polypeptide binding]; other site 875328008749 tandem repeat interface [polypeptide binding]; other site 875328008750 active site residues [active] 875328008751 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328008752 PPE family; Region: PPE; pfam00823 875328008753 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 875328008754 Short C-terminal domain; Region: SHOCT; pfam09851 875328008755 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328008756 potential frameshift: common BLAST hit: gi|253797667|ref|YP_003030668.1| protease IV sppA 875328008757 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 875328008758 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 875328008759 tandem repeat interface [polypeptide binding]; other site 875328008760 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 875328008761 oligomer interface [polypeptide binding]; other site 875328008762 active site residues [active] 875328008763 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 875328008764 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 875328008765 23S rRNA binding site [nucleotide binding]; other site 875328008766 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 875328008767 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 875328008768 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 875328008769 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 875328008770 5S rRNA interface [nucleotide binding]; other site 875328008771 L27 interface [polypeptide binding]; other site 875328008772 23S rRNA interface [nucleotide binding]; other site 875328008773 L5 interface [polypeptide binding]; other site 875328008774 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 875328008775 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 875328008776 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 875328008777 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 875328008778 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 875328008779 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 875328008780 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 875328008781 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 875328008782 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 875328008783 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 875328008784 RNA binding site [nucleotide binding]; other site 875328008785 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 875328008786 Uncharacterized conserved protein [Function unknown]; Region: COG1262 875328008787 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 875328008788 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 875328008789 Sulfatase; Region: Sulfatase; pfam00884 875328008790 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 875328008791 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 875328008792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 875328008793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 875328008794 dimerization interface [polypeptide binding]; other site 875328008795 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 875328008796 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 875328008797 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 875328008798 putative translocon interaction site; other site 875328008799 23S rRNA interface [nucleotide binding]; other site 875328008800 signal recognition particle (SRP54) interaction site; other site 875328008801 L23 interface [polypeptide binding]; other site 875328008802 trigger factor interaction site; other site 875328008803 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 875328008804 23S rRNA interface [nucleotide binding]; other site 875328008805 5S rRNA interface [nucleotide binding]; other site 875328008806 putative antibiotic binding site [chemical binding]; other site 875328008807 L25 interface [polypeptide binding]; other site 875328008808 L27 interface [polypeptide binding]; other site 875328008809 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 875328008810 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 875328008811 G-X-X-G motif; other site 875328008812 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 875328008813 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 875328008814 putative translocon binding site; other site 875328008815 protein-rRNA interface [nucleotide binding]; other site 875328008816 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 875328008817 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 875328008818 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 875328008819 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 875328008820 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 875328008821 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 875328008822 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 875328008823 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 875328008824 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328008825 CoenzymeA binding site [chemical binding]; other site 875328008826 subunit interaction site [polypeptide binding]; other site 875328008827 PHB binding site; other site 875328008828 Carboxylesterase family; Region: COesterase; pfam00135 875328008829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328008830 substrate binding pocket [chemical binding]; other site 875328008831 catalytic triad [active] 875328008832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328008833 Cytochrome P450; Region: p450; cl12078 875328008834 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 875328008835 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 875328008836 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 875328008837 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 875328008838 Probable Catalytic site; other site 875328008839 metal-binding site 875328008840 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 875328008841 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 875328008842 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 875328008843 phosphate binding site [ion binding]; other site 875328008844 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 875328008845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 875328008846 FeS/SAM binding site; other site 875328008847 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 875328008848 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 875328008849 mycofactocin precursor; Region: mycofactocin; TIGR03969 875328008850 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 875328008851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328008852 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 875328008853 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328008854 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328008855 SnoaL-like domain; Region: SnoaL_2; pfam12680 875328008856 Ecdysteroid kinase; Region: EcKinase; cl17738 875328008857 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328008858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328008859 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328008860 iron-sulfur cluster [ion binding]; other site 875328008861 [2Fe-2S] cluster binding site [ion binding]; other site 875328008862 Isochorismatase family; Region: Isochorismatase; pfam00857 875328008863 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 875328008864 catalytic triad [active] 875328008865 conserved cis-peptide bond; other site 875328008866 acyl-CoA synthetase; Validated; Region: PRK07798 875328008867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328008868 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 875328008869 acyl-activating enzyme (AAE) consensus motif; other site 875328008870 acyl-activating enzyme (AAE) consensus motif; other site 875328008871 putative AMP binding site [chemical binding]; other site 875328008872 putative active site [active] 875328008873 putative CoA binding site [chemical binding]; other site 875328008874 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 875328008875 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 875328008876 NAD(P) binding site [chemical binding]; other site 875328008877 catalytic residues [active] 875328008878 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 875328008879 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328008880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328008881 NAD(P) binding site [chemical binding]; other site 875328008882 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 875328008883 active site 875328008884 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328008885 Cytochrome P450; Region: p450; cl12078 875328008886 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328008887 Cytochrome P450; Region: p450; cl12078 875328008888 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 875328008889 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 875328008890 NAD binding site [chemical binding]; other site 875328008891 catalytic residues [active] 875328008892 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328008893 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328008894 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 875328008895 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328008896 CoenzymeA binding site [chemical binding]; other site 875328008897 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 875328008898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328008899 NAD(P) binding site [chemical binding]; other site 875328008900 active site 875328008901 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328008902 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328008903 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 875328008904 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328008905 active site 875328008906 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328008907 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 875328008908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328008909 NAD(P) binding site [chemical binding]; other site 875328008910 active site 875328008911 SnoaL-like domain; Region: SnoaL_3; pfam13474 875328008912 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328008913 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328008914 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328008915 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328008916 active site 875328008917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008918 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328008919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328008920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328008921 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008922 active site 875328008923 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 875328008924 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 875328008925 putative NADP binding site [chemical binding]; other site 875328008926 putative substrate binding site [chemical binding]; other site 875328008927 active site 875328008928 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328008929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328008930 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 875328008931 classical (c) SDRs; Region: SDR_c; cd05233 875328008932 NAD(P) binding site [chemical binding]; other site 875328008933 active site 875328008934 PemK-like protein; Region: PemK; pfam02452 875328008935 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 875328008936 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328008937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 875328008938 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 875328008939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328008940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328008941 active site 875328008942 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 875328008943 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328008944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328008945 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 875328008946 acyl-CoA synthetase; Validated; Region: PRK07798 875328008947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328008948 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 875328008949 acyl-activating enzyme (AAE) consensus motif; other site 875328008950 acyl-activating enzyme (AAE) consensus motif; other site 875328008951 putative AMP binding site [chemical binding]; other site 875328008952 putative active site [active] 875328008953 putative CoA binding site [chemical binding]; other site 875328008954 CoA binding site [chemical binding]; other site 875328008955 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328008956 enoyl-CoA hydratase; Provisional; Region: PRK06210 875328008957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008958 substrate binding site [chemical binding]; other site 875328008959 oxyanion hole (OAH) forming residues; other site 875328008960 trimer interface [polypeptide binding]; other site 875328008961 classical (c) SDRs; Region: SDR_c; cd05233 875328008962 NAD(P) binding site [chemical binding]; other site 875328008963 active site 875328008964 enoyl-CoA hydratase; Provisional; Region: PRK08252 875328008965 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008966 substrate binding site [chemical binding]; other site 875328008967 oxyanion hole (OAH) forming residues; other site 875328008968 trimer interface [polypeptide binding]; other site 875328008969 tetracycline repressor protein TetR; Provisional; Region: PRK13756 875328008970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328008971 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 875328008972 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328008973 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 875328008974 dimer interface [polypeptide binding]; other site 875328008975 active site 875328008976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008977 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 875328008978 substrate binding site [chemical binding]; other site 875328008979 oxyanion hole (OAH) forming residues; other site 875328008980 trimer interface [polypeptide binding]; other site 875328008981 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328008982 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008983 substrate binding site [chemical binding]; other site 875328008984 oxyanion hole (OAH) forming residues; other site 875328008985 trimer interface [polypeptide binding]; other site 875328008986 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328008987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008988 substrate binding site [chemical binding]; other site 875328008989 oxyanion hole (OAH) forming residues; other site 875328008990 trimer interface [polypeptide binding]; other site 875328008991 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328008992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328008993 substrate binding site [chemical binding]; other site 875328008994 oxyanion hole (OAH) forming residues; other site 875328008995 trimer interface [polypeptide binding]; other site 875328008996 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328008997 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328008998 acyl-activating enzyme (AAE) consensus motif; other site 875328008999 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009000 acyl-activating enzyme (AAE) consensus motif; other site 875328009001 AMP binding site [chemical binding]; other site 875328009002 active site 875328009003 CoA binding site [chemical binding]; other site 875328009004 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328009005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009007 acyl-activating enzyme (AAE) consensus motif; other site 875328009008 acyl-activating enzyme (AAE) consensus motif; other site 875328009009 AMP binding site [chemical binding]; other site 875328009010 active site 875328009011 CoA binding site [chemical binding]; other site 875328009012 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328009013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009014 acyl-activating enzyme (AAE) consensus motif; other site 875328009015 AMP binding site [chemical binding]; other site 875328009016 active site 875328009017 CoA binding site [chemical binding]; other site 875328009018 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328009019 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328009020 active site 875328009021 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 875328009022 putative active site [active] 875328009023 Transcriptional regulators [Transcription]; Region: GntR; COG1802 875328009024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328009025 DNA-binding site [nucleotide binding]; DNA binding site 875328009026 FCD domain; Region: FCD; pfam07729 875328009027 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009028 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009029 active site 875328009030 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 875328009031 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328009032 dimer interface [polypeptide binding]; other site 875328009033 active site 875328009034 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009036 NAD(P) binding site [chemical binding]; other site 875328009037 active site 875328009038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009039 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009040 active site 875328009041 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328009042 classical (c) SDRs; Region: SDR_c; cd05233 875328009043 NAD(P) binding site [chemical binding]; other site 875328009044 active site 875328009045 AMP-binding enzyme; Region: AMP-binding; pfam00501 875328009046 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 875328009047 AMP binding site [chemical binding]; other site 875328009048 active site 875328009049 acyl-activating enzyme (AAE) consensus motif; other site 875328009050 CoA binding site [chemical binding]; other site 875328009051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009052 Cytochrome P450; Region: p450; cl12078 875328009053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 875328009054 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 875328009055 Walker A motif; other site 875328009056 ATP binding site [chemical binding]; other site 875328009057 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 875328009058 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 875328009059 metal ion-dependent adhesion site (MIDAS); other site 875328009060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009061 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 875328009062 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 875328009063 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009064 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 875328009065 acyl-activating enzyme (AAE) consensus motif; other site 875328009066 acyl-activating enzyme (AAE) consensus motif; other site 875328009067 putative AMP binding site [chemical binding]; other site 875328009068 putative active site [active] 875328009069 putative CoA binding site [chemical binding]; other site 875328009070 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328009071 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 875328009072 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009073 acyl-activating enzyme (AAE) consensus motif; other site 875328009074 AMP binding site [chemical binding]; other site 875328009075 active site 875328009076 CoA binding site [chemical binding]; other site 875328009077 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328009078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009079 substrate binding site [chemical binding]; other site 875328009080 oxyanion hole (OAH) forming residues; other site 875328009081 trimer interface [polypeptide binding]; other site 875328009082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009084 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009085 Cytochrome P450; Region: p450; cl12078 875328009086 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009087 Cytochrome P450; Region: p450; cl12078 875328009088 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328009089 classical (c) SDRs; Region: SDR_c; cd05233 875328009090 NAD(P) binding site [chemical binding]; other site 875328009091 active site 875328009092 Phosphotransferase enzyme family; Region: APH; pfam01636 875328009093 Ecdysteroid kinase; Region: EcKinase; cl17738 875328009094 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328009095 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328009096 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328009097 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328009098 enoyl-CoA hydratase; Provisional; Region: PRK12478 875328009099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009100 substrate binding site [chemical binding]; other site 875328009101 oxyanion hole (OAH) forming residues; other site 875328009102 trimer interface [polypeptide binding]; other site 875328009103 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 875328009104 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 875328009105 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 875328009106 active site 875328009107 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 875328009108 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 875328009109 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 875328009110 active site 875328009111 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328009112 Cytochrome P450; Region: p450; cl12078 875328009113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009114 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 875328009115 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 875328009116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009117 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 875328009118 classical (c) SDRs; Region: SDR_c; cd05233 875328009119 NAD(P) binding site [chemical binding]; other site 875328009120 active site 875328009121 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009122 Cytochrome P450; Region: p450; cl12078 875328009123 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328009124 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328009125 [2Fe-2S] cluster binding site [ion binding]; other site 875328009126 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 875328009127 putative alpha subunit interface [polypeptide binding]; other site 875328009128 putative active site [active] 875328009129 putative substrate binding site [chemical binding]; other site 875328009130 Fe binding site [ion binding]; other site 875328009131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009132 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328009133 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328009134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009136 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 875328009137 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 875328009138 NAD binding site [chemical binding]; other site 875328009139 catalytic residues [active] 875328009140 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328009141 SnoaL-like domain; Region: SnoaL_3; pfam13474 875328009142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328009143 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 875328009144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328009145 Putative cyclase; Region: Cyclase; pfam04199 875328009146 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009147 NAD(P) binding site [chemical binding]; other site 875328009148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009149 active site 875328009150 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 875328009151 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 875328009152 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 875328009153 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328009154 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 875328009155 active site 875328009156 metal binding site [ion binding]; metal-binding site 875328009157 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 875328009158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328009159 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328009160 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328009161 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 875328009162 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 875328009163 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 875328009164 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328009165 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009166 mce related protein; Region: MCE; pfam02470 875328009167 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009168 mce related protein; Region: MCE; pfam02470 875328009169 mce related protein; Region: MCE; pfam02470 875328009170 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328009171 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009172 mce related protein; Region: MCE; pfam02470 875328009173 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009174 mce related protein; Region: MCE; pfam02470 875328009175 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009176 mce related protein; Region: MCE; pfam02470 875328009177 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328009178 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 875328009179 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009180 active site 875328009181 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009182 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328009183 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328009184 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 875328009185 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 875328009186 NAD binding site [chemical binding]; other site 875328009187 catalytic residues [active] 875328009188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009190 NAD(P) binding site [chemical binding]; other site 875328009191 active site 875328009192 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328009193 classical (c) SDRs; Region: SDR_c; cd05233 875328009194 NAD(P) binding site [chemical binding]; other site 875328009195 active site 875328009196 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 875328009197 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009198 Cytochrome P450; Region: p450; cl12078 875328009199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009200 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009201 active site 875328009202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009204 active site 875328009205 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328009206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328009207 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328009208 iron-sulfur cluster [ion binding]; other site 875328009209 [2Fe-2S] cluster binding site [ion binding]; other site 875328009210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328009211 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 875328009212 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 875328009213 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 875328009214 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328009215 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009216 lipid-transfer protein; Provisional; Region: PRK07855 875328009217 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009218 active site 875328009219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328009220 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328009221 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 875328009222 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009223 Cytochrome P450; Region: p450; cl12078 875328009224 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 875328009225 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 875328009226 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 875328009227 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 875328009228 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009229 Cytochrome P450; Region: p450; cl12078 875328009230 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328009231 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 875328009232 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328009233 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328009234 [2Fe-2S] cluster binding site [ion binding]; other site 875328009235 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 875328009236 alpha subunit interface [polypeptide binding]; other site 875328009237 active site 875328009238 substrate binding site [chemical binding]; other site 875328009239 Fe binding site [ion binding]; other site 875328009240 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 875328009241 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 875328009242 active site 875328009243 SnoaL-like domain; Region: SnoaL_4; pfam13577 875328009244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009245 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009246 active site 875328009247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009249 active site 875328009250 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009251 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009252 active site 875328009253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328009256 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328009257 NAD(P) binding site [chemical binding]; other site 875328009258 catalytic residues [active] 875328009259 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328009260 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 875328009261 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 875328009262 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328009263 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 875328009264 G4 box; other site 875328009265 G5 box; other site 875328009266 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328009267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009268 substrate binding site [chemical binding]; other site 875328009269 oxyanion hole (OAH) forming residues; other site 875328009270 trimer interface [polypeptide binding]; other site 875328009271 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009273 active site 875328009274 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328009275 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009278 AMP-binding enzyme; Region: AMP-binding; pfam00501 875328009279 acyl-activating enzyme (AAE) consensus motif; other site 875328009280 active site 875328009281 AMP binding site [chemical binding]; other site 875328009282 CoA binding site [chemical binding]; other site 875328009283 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328009284 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 875328009285 FAD binding pocket [chemical binding]; other site 875328009286 FAD binding motif [chemical binding]; other site 875328009287 phosphate binding motif [ion binding]; other site 875328009288 beta-alpha-beta structure motif; other site 875328009289 NAD(p) ribose binding residues [chemical binding]; other site 875328009290 NAD binding pocket [chemical binding]; other site 875328009291 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 875328009292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328009293 catalytic loop [active] 875328009294 iron binding site [ion binding]; other site 875328009295 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 875328009296 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328009297 NAD binding site [chemical binding]; other site 875328009298 catalytic residues [active] 875328009299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009300 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009301 NAD(P) binding site [chemical binding]; other site 875328009302 active site 875328009303 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 875328009304 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 875328009305 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328009306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328009307 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328009308 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328009309 [2Fe-2S] cluster binding site [ion binding]; other site 875328009310 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 875328009311 putative alpha subunit interface [polypeptide binding]; other site 875328009312 putative active site [active] 875328009313 putative substrate binding site [chemical binding]; other site 875328009314 Fe binding site [ion binding]; other site 875328009315 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328009316 classical (c) SDRs; Region: SDR_c; cd05233 875328009317 NAD(P) binding site [chemical binding]; other site 875328009318 active site 875328009319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009320 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 875328009321 homodimer interface [polypeptide binding]; other site 875328009322 putative substrate binding pocket [chemical binding]; other site 875328009323 diiron center [ion binding]; other site 875328009324 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 875328009325 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 875328009326 FMN binding site [chemical binding]; other site 875328009327 active site 875328009328 catalytic residues [active] 875328009329 substrate binding site [chemical binding]; other site 875328009330 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 875328009331 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 875328009332 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 875328009333 PhoU domain; Region: PhoU; pfam01895 875328009334 PhoU domain; Region: PhoU; pfam01895 875328009335 PBP superfamily domain; Region: PBP_like_2; cl17296 875328009336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328009337 dimer interface [polypeptide binding]; other site 875328009338 conserved gate region; other site 875328009339 putative PBP binding loops; other site 875328009340 ABC-ATPase subunit interface; other site 875328009341 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 875328009342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328009343 dimer interface [polypeptide binding]; other site 875328009344 conserved gate region; other site 875328009345 putative PBP binding loops; other site 875328009346 ABC-ATPase subunit interface; other site 875328009347 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 875328009348 Catalytic domain of Protein Kinases; Region: PKc; cd00180 875328009349 active site 875328009350 ATP binding site [chemical binding]; other site 875328009351 substrate binding site [chemical binding]; other site 875328009352 activation loop (A-loop); other site 875328009353 Uncharacterized conserved protein [Function unknown]; Region: COG3391 875328009354 NHL repeat; Region: NHL; pfam01436 875328009355 NHL repeat; Region: NHL; pfam01436 875328009356 NHL repeat; Region: NHL; pfam01436 875328009357 NHL repeat; Region: NHL; pfam01436 875328009358 PBP superfamily domain; Region: PBP_like_2; cl17296 875328009359 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 875328009360 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 875328009361 Walker A/P-loop; other site 875328009362 ATP binding site [chemical binding]; other site 875328009363 Q-loop/lid; other site 875328009364 ABC transporter signature motif; other site 875328009365 Walker B; other site 875328009366 D-loop; other site 875328009367 H-loop/switch region; other site 875328009368 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 875328009369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328009370 dimer interface [polypeptide binding]; other site 875328009371 conserved gate region; other site 875328009372 putative PBP binding loops; other site 875328009373 ABC-ATPase subunit interface; other site 875328009374 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 875328009375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328009376 dimer interface [polypeptide binding]; other site 875328009377 conserved gate region; other site 875328009378 putative PBP binding loops; other site 875328009379 ABC-ATPase subunit interface; other site 875328009380 PBP superfamily domain; Region: PBP_like_2; cl17296 875328009381 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 875328009382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 875328009383 Coenzyme A binding pocket [chemical binding]; other site 875328009384 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 875328009385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328009386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328009387 DNA binding site [nucleotide binding] 875328009388 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 875328009389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 875328009390 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328009391 catalytic residues [active] 875328009392 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 875328009393 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 875328009394 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 875328009395 active site residue [active] 875328009396 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 875328009397 active site residue [active] 875328009398 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 875328009399 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 875328009400 heme-binding site [chemical binding]; other site 875328009401 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 875328009402 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 875328009403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328009404 catalytic residue [active] 875328009405 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 875328009406 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 875328009407 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 875328009408 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 875328009409 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 875328009410 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 875328009411 dimerization interface [polypeptide binding]; other site 875328009412 putative ATP binding site [chemical binding]; other site 875328009413 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009415 active site 875328009416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009417 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328009418 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328009419 active site 875328009420 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 875328009421 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 875328009422 substrate binding pocket [chemical binding]; other site 875328009423 active site 875328009424 iron coordination sites [ion binding]; other site 875328009425 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328009426 [2Fe-2S] cluster binding site [ion binding]; other site 875328009427 iron-sulfur cluster [ion binding]; other site 875328009428 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 875328009429 alpha subunit interface [polypeptide binding]; other site 875328009430 active site 875328009431 substrate binding site [chemical binding]; other site 875328009432 Fe binding site [ion binding]; other site 875328009433 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009435 NAD(P) binding site [chemical binding]; other site 875328009436 active site 875328009437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009438 MoxR-like ATPases [General function prediction only]; Region: COG0714 875328009439 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 875328009440 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 875328009441 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 875328009442 metal ion-dependent adhesion site (MIDAS); other site 875328009443 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328009444 MarR family; Region: MarR_2; pfam12802 875328009445 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328009446 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 875328009447 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 875328009448 active site 875328009449 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328009450 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328009451 [2Fe-2S] cluster binding site [ion binding]; other site 875328009452 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 875328009453 alpha subunit interface [polypeptide binding]; other site 875328009454 active site 875328009455 substrate binding site [chemical binding]; other site 875328009456 Fe binding site [ion binding]; other site 875328009457 amidophosphoribosyltransferase; Provisional; Region: PRK07847 875328009458 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 875328009459 tetramer interface [polypeptide binding]; other site 875328009460 active site 875328009461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328009462 active site 875328009463 Predicted membrane protein [Function unknown]; Region: COG4425 875328009464 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 875328009465 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 875328009466 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 875328009467 dimerization interface [polypeptide binding]; other site 875328009468 ATP binding site [chemical binding]; other site 875328009469 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 875328009470 dimerization interface [polypeptide binding]; other site 875328009471 ATP binding site [chemical binding]; other site 875328009472 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 875328009473 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 875328009474 active site 875328009475 metal binding site [ion binding]; metal-binding site 875328009476 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 875328009477 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 875328009478 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 875328009479 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 875328009480 putative active site [active] 875328009481 catalytic triad [active] 875328009482 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 875328009483 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 875328009484 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 875328009485 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328009486 FAD binding domain; Region: FAD_binding_2; pfam00890 875328009487 Predicted deacetylase [General function prediction only]; Region: COG3233 875328009488 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 875328009489 putative active site [active] 875328009490 putative Zn binding site [ion binding]; other site 875328009491 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 875328009492 Predicted membrane protein [Function unknown]; Region: COG4325 875328009493 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 875328009494 catalytic residues [active] 875328009495 dimer interface [polypeptide binding]; other site 875328009496 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 875328009497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328009498 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 875328009499 ATP binding site [chemical binding]; other site 875328009500 active site 875328009501 substrate binding site [chemical binding]; other site 875328009502 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 875328009503 Ion channel; Region: Ion_trans_2; pfam07885 875328009504 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 875328009505 TrkA-N domain; Region: TrkA_N; pfam02254 875328009506 TrkA-N domain; Region: TrkA_N; pfam02254 875328009507 TrkA-C domain; Region: TrkA_C; pfam02080 875328009508 adenylosuccinate lyase; Region: purB; TIGR00928 875328009509 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 875328009510 tetramer interface [polypeptide binding]; other site 875328009511 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 875328009512 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 875328009513 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 875328009514 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 875328009515 ligand binding site [chemical binding]; other site 875328009516 homodimer interface [polypeptide binding]; other site 875328009517 NAD(P) binding site [chemical binding]; other site 875328009518 trimer interface B [polypeptide binding]; other site 875328009519 trimer interface A [polypeptide binding]; other site 875328009520 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 875328009521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 875328009522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009523 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 875328009524 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 875328009525 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 875328009526 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 875328009527 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 875328009528 classical (c) SDRs; Region: SDR_c; cd05233 875328009529 NAD(P) binding site [chemical binding]; other site 875328009530 active site 875328009531 enoyl-CoA hydratase; Provisional; Region: PRK06688 875328009532 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009533 substrate binding site [chemical binding]; other site 875328009534 oxyanion hole (OAH) forming residues; other site 875328009535 trimer interface [polypeptide binding]; other site 875328009536 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 875328009537 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 875328009538 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 875328009539 short chain dehydrogenase; Provisional; Region: PRK07774 875328009540 classical (c) SDRs; Region: SDR_c; cd05233 875328009541 NAD(P) binding site [chemical binding]; other site 875328009542 active site 875328009543 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 875328009544 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 875328009545 NAD binding site [chemical binding]; other site 875328009546 catalytic residues [active] 875328009547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009548 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009549 Cytochrome P450; Region: p450; cl12078 875328009550 short chain dehydrogenase; Provisional; Region: PRK07775 875328009551 classical (c) SDRs; Region: SDR_c; cd05233 875328009552 NAD(P) binding site [chemical binding]; other site 875328009553 active site 875328009554 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009555 Cytochrome P450; Region: p450; cl12078 875328009556 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 875328009557 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 875328009558 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 875328009559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009560 NAD(P) binding site [chemical binding]; other site 875328009561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009562 active site 875328009563 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009564 Cytochrome P450; Region: p450; cl12078 875328009565 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 875328009566 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 875328009567 NAD binding site [chemical binding]; other site 875328009568 catalytic Zn binding site [ion binding]; other site 875328009569 substrate binding site [chemical binding]; other site 875328009570 structural Zn binding site [ion binding]; other site 875328009571 YceI-like domain; Region: YceI; pfam04264 875328009572 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 875328009573 nucleotide binding site/active site [active] 875328009574 HIT family signature motif; other site 875328009575 catalytic residue [active] 875328009576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328009577 dimer interface [polypeptide binding]; other site 875328009578 phosphorylation site [posttranslational modification] 875328009579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328009580 ATP binding site [chemical binding]; other site 875328009581 Mg2+ binding site [ion binding]; other site 875328009582 G-X-G motif; other site 875328009583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328009584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328009585 active site 875328009586 phosphorylation site [posttranslational modification] 875328009587 intermolecular recognition site; other site 875328009588 dimerization interface [polypeptide binding]; other site 875328009589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328009590 DNA binding site [nucleotide binding] 875328009591 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 875328009592 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 875328009593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 875328009595 NAD(P) binding site [chemical binding]; other site 875328009596 active site 875328009597 short chain dehydrogenase; Provisional; Region: PRK05875 875328009598 classical (c) SDRs; Region: SDR_c; cd05233 875328009599 NAD(P) binding site [chemical binding]; other site 875328009600 active site 875328009601 enoyl-CoA hydratase; Provisional; Region: PRK08290 875328009602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009603 substrate binding site [chemical binding]; other site 875328009604 oxyanion hole (OAH) forming residues; other site 875328009605 trimer interface [polypeptide binding]; other site 875328009606 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 875328009607 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 875328009608 active site 875328009609 homotetramer interface [polypeptide binding]; other site 875328009610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009611 mce related protein; Region: MCE; pfam02470 875328009612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009613 mce related protein; Region: MCE; pfam02470 875328009614 mce related protein; Region: MCE; pfam02470 875328009615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009616 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009617 mce related protein; Region: MCE; pfam02470 875328009618 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009619 mce related protein; Region: MCE; pfam02470 875328009620 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328009621 mce related protein; Region: MCE; pfam02470 875328009622 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328009623 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328009624 Permease; Region: Permease; pfam02405 875328009625 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328009626 Permease; Region: Permease; pfam02405 875328009627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 875328009628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009629 NAD(P) binding site [chemical binding]; other site 875328009630 active site 875328009631 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 875328009632 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 875328009633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009634 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 875328009635 FAD binding site [chemical binding]; other site 875328009636 substrate binding site [chemical binding]; other site 875328009637 catalytic base [active] 875328009638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009639 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 875328009640 active site 875328009641 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328009642 acyl-CoA synthetase; Validated; Region: PRK07867 875328009643 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009644 acyl-activating enzyme (AAE) consensus motif; other site 875328009645 AMP binding site [chemical binding]; other site 875328009646 active site 875328009647 CoA binding site [chemical binding]; other site 875328009648 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 875328009649 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 875328009650 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 875328009651 Ligand Binding Site [chemical binding]; other site 875328009652 Molecular Tunnel; other site 875328009653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 875328009654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 875328009655 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 875328009656 Walker A/P-loop; other site 875328009657 ATP binding site [chemical binding]; other site 875328009658 Q-loop/lid; other site 875328009659 ABC transporter signature motif; other site 875328009660 Walker B; other site 875328009661 D-loop; other site 875328009662 H-loop/switch region; other site 875328009663 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 875328009664 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 875328009665 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 875328009666 NAD(P) binding site [chemical binding]; other site 875328009667 catalytic residues [active] 875328009668 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328009669 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328009670 acyl-CoA synthetase; Validated; Region: PRK07798 875328009671 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009672 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 875328009673 acyl-activating enzyme (AAE) consensus motif; other site 875328009674 acyl-activating enzyme (AAE) consensus motif; other site 875328009675 putative AMP binding site [chemical binding]; other site 875328009676 putative active site [active] 875328009677 putative CoA binding site [chemical binding]; other site 875328009678 enoyl-CoA hydratase; Provisional; Region: PRK07799 875328009679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009680 substrate binding site [chemical binding]; other site 875328009681 oxyanion hole (OAH) forming residues; other site 875328009682 trimer interface [polypeptide binding]; other site 875328009683 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328009684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009685 NAD(P) binding site [chemical binding]; other site 875328009686 active site 875328009687 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009688 Cytochrome P450; Region: p450; cl12078 875328009689 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 875328009690 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 875328009691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009692 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 875328009693 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328009694 acyl-activating enzyme (AAE) consensus motif; other site 875328009695 putative AMP binding site [chemical binding]; other site 875328009696 putative active site [active] 875328009697 acyl-activating enzyme (AAE) consensus motif; other site 875328009698 putative CoA binding site [chemical binding]; other site 875328009699 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328009700 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 875328009701 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 875328009702 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009703 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 875328009704 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009705 lipid-transfer protein; Provisional; Region: PRK07937 875328009706 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 875328009707 active site 875328009708 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 875328009709 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009710 active site 875328009711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328009712 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328009713 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 875328009714 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 875328009715 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 875328009716 trimer interface [polypeptide binding]; other site 875328009717 putative metal binding site [ion binding]; other site 875328009718 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328009719 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 875328009720 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 875328009721 hydrophobic ligand binding site; other site 875328009722 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 875328009723 short chain dehydrogenase; Provisional; Region: PRK07890 875328009724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009725 NAD(P) binding site [chemical binding]; other site 875328009726 active site 875328009727 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328009728 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 875328009729 SnoaL-like domain; Region: SnoaL_4; pfam13577 875328009730 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328009731 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 875328009732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328009733 ATP binding site [chemical binding]; other site 875328009734 putative Mg++ binding site [ion binding]; other site 875328009735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328009736 nucleotide binding region [chemical binding]; other site 875328009737 ATP-binding site [chemical binding]; other site 875328009738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328009739 active site 875328009740 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 875328009741 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 875328009742 active site 875328009743 catalytic residues [active] 875328009744 metal binding site [ion binding]; metal-binding site 875328009745 DmpG-like communication domain; Region: DmpG_comm; pfam07836 875328009746 acetaldehyde dehydrogenase; Validated; Region: PRK08300 875328009747 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 875328009748 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 875328009749 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 875328009750 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009751 Cytochrome P450; Region: p450; cl12078 875328009752 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 875328009753 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328009754 enoyl-CoA hydratase; Region: PLN02864 875328009755 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 875328009756 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 875328009757 dimer interaction site [polypeptide binding]; other site 875328009758 substrate-binding tunnel; other site 875328009759 active site 875328009760 catalytic site [active] 875328009761 substrate binding site [chemical binding]; other site 875328009762 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328009763 PPE family; Region: PPE; pfam00823 875328009764 lipid-transfer protein; Provisional; Region: PRK07855 875328009765 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009766 active site 875328009767 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 875328009768 putative active site [active] 875328009769 putative catalytic site [active] 875328009770 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 875328009771 active site 875328009772 catalytic site [active] 875328009773 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 875328009774 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009776 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009777 active site 875328009778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009779 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328009780 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009781 active site 875328009782 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009783 Cytochrome P450; Region: p450; cl12078 875328009784 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009785 Cytochrome P450; Region: p450; cl12078 875328009786 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 875328009787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328009788 dimer interface [polypeptide binding]; other site 875328009789 active site 875328009790 Domain of unknown function (DUF385); Region: DUF385; pfam04075 875328009791 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328009792 Predicted ATPase [General function prediction only]; Region: COG3903 875328009793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 875328009794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 875328009795 DNA binding residues [nucleotide binding] 875328009796 dimerization interface [polypeptide binding]; other site 875328009797 short chain dehydrogenase; Provisional; Region: PRK07791 875328009798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009799 NAD(P) binding site [chemical binding]; other site 875328009800 active site 875328009801 short chain dehydrogenase; Provisional; Region: PRK07856 875328009802 classical (c) SDRs; Region: SDR_c; cd05233 875328009803 NAD(P) binding site [chemical binding]; other site 875328009804 active site 875328009805 enoyl-CoA hydratase; Provisional; Region: PRK06495 875328009806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009807 substrate binding site [chemical binding]; other site 875328009808 oxyanion hole (OAH) forming residues; other site 875328009809 trimer interface [polypeptide binding]; other site 875328009810 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 875328009811 Coenzyme A transferase; Region: CoA_trans; cl17247 875328009812 Nitronate monooxygenase; Region: NMO; pfam03060 875328009813 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328009814 FMN binding site [chemical binding]; other site 875328009815 substrate binding site [chemical binding]; other site 875328009816 putative catalytic residue [active] 875328009817 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 875328009818 putative active site [active] 875328009819 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 875328009820 active site 875328009821 metal binding site [ion binding]; metal-binding site 875328009822 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 875328009823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009825 WHG domain; Region: WHG; pfam13305 875328009826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009828 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 875328009829 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328009830 dimer interface [polypeptide binding]; other site 875328009831 active site 875328009832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009834 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 875328009835 short chain dehydrogenase; Provisional; Region: PRK07831 875328009836 classical (c) SDRs; Region: SDR_c; cd05233 875328009837 NAD(P) binding site [chemical binding]; other site 875328009838 active site 875328009839 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009841 active site 875328009842 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 875328009843 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009844 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009845 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 875328009846 acyl-activating enzyme (AAE) consensus motif; other site 875328009847 acyl-activating enzyme (AAE) consensus motif; other site 875328009848 putative AMP binding site [chemical binding]; other site 875328009849 putative active site [active] 875328009850 putative CoA binding site [chemical binding]; other site 875328009851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009852 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009853 active site 875328009854 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328009855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009857 active site 875328009858 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328009859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009860 active site 875328009861 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 875328009862 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 875328009863 Secretory lipase; Region: LIP; pfam03583 875328009864 aspartate aminotransferase; Provisional; Region: PRK05764 875328009865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328009866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328009867 homodimer interface [polypeptide binding]; other site 875328009868 catalytic residue [active] 875328009869 hypothetical protein; Provisional; Region: PRK05865 875328009870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009871 NAD(P) binding site [chemical binding]; other site 875328009872 active site 875328009873 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328009874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009875 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 875328009876 classical (c) SDRs; Region: SDR_c; cd05233 875328009877 NAD(P) binding site [chemical binding]; other site 875328009878 active site 875328009879 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328009880 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328009881 NAD(P) binding site [chemical binding]; other site 875328009882 catalytic residues [active] 875328009883 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328009884 Cytochrome P450; Region: p450; cl12078 875328009885 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 875328009886 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 875328009887 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 875328009888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328009889 catalytic core [active] 875328009890 thiolase; Provisional; Region: PRK06158 875328009891 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009892 active site 875328009893 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328009894 hypothetical protein; Provisional; Region: PRK05865 875328009895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009896 NAD(P) binding site [chemical binding]; other site 875328009897 active site 875328009898 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328009899 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 875328009900 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 875328009901 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328009902 lipid-transfer protein; Provisional; Region: PRK08256 875328009903 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328009904 active site 875328009905 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328009906 active site 2 [active] 875328009907 active site 1 [active] 875328009908 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 875328009909 active site 2 [active] 875328009910 active site 1 [active] 875328009911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009912 short chain dehydrogenase; Provisional; Region: PRK07791 875328009913 NAD(P) binding site [chemical binding]; other site 875328009914 active site 875328009915 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328009916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009917 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328009918 acyl-activating enzyme (AAE) consensus motif; other site 875328009919 acyl-activating enzyme (AAE) consensus motif; other site 875328009920 AMP binding site [chemical binding]; other site 875328009921 active site 875328009922 CoA binding site [chemical binding]; other site 875328009923 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328009924 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328009925 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328009926 classical (c) SDRs; Region: SDR_c; cd05233 875328009927 NAD(P) binding site [chemical binding]; other site 875328009928 active site 875328009929 enoyl-CoA hydratase; Provisional; Region: PRK07827 875328009930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009931 substrate binding site [chemical binding]; other site 875328009932 oxyanion hole (OAH) forming residues; other site 875328009933 trimer interface [polypeptide binding]; other site 875328009934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009935 active site 875328009936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009937 Transcriptional regulators [Transcription]; Region: FadR; COG2186 875328009938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 875328009939 DNA-binding site [nucleotide binding]; DNA binding site 875328009940 FCD domain; Region: FCD; pfam07729 875328009941 pyruvate phosphate dikinase; Provisional; Region: PRK05878 875328009942 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 875328009943 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328009944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009946 active site 875328009947 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 875328009948 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 875328009949 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328009950 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 875328009951 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 875328009952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 875328009953 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 875328009954 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 875328009955 carboxyltransferase (CT) interaction site; other site 875328009956 biotinylation site [posttranslational modification]; other site 875328009957 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 875328009958 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009959 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009960 active site 875328009961 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328009962 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328009963 substrate binding site [chemical binding]; other site 875328009964 oxyanion hole (OAH) forming residues; other site 875328009965 trimer interface [polypeptide binding]; other site 875328009966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009967 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 875328009968 NAD(P) binding site [chemical binding]; other site 875328009969 active site 875328009970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009972 active site 875328009973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328009974 classical (c) SDRs; Region: SDR_c; cd05233 875328009975 NAD(P) binding site [chemical binding]; other site 875328009976 active site 875328009977 putative transposase OrfB; Reviewed; Region: PHA02517 875328009978 HTH-like domain; Region: HTH_21; pfam13276 875328009979 Integrase core domain; Region: rve; pfam00665 875328009980 Integrase core domain; Region: rve_3; pfam13683 875328009981 Transposase; Region: HTH_Tnp_1; pfam01527 875328009982 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 875328009983 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 875328009984 molybdopterin cofactor binding site; other site 875328009985 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 875328009986 molybdopterin cofactor binding site; other site 875328009987 Transposase, Mutator family; Region: Transposase_mut; pfam00872 875328009988 MULE transposase domain; Region: MULE; pfam10551 875328009989 hypothetical protein; Provisional; Region: PRK05865 875328009990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328009991 NAD(P) binding site [chemical binding]; other site 875328009992 active site 875328009993 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328009994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328009995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328009996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328009997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328009998 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 875328009999 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 875328010000 FAD binding site [chemical binding]; other site 875328010001 substrate binding site [chemical binding]; other site 875328010002 catalytic base [active] 875328010003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010004 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328010005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010007 active site 875328010008 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 875328010009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328010010 motif II; other site 875328010011 AMP-binding enzyme; Region: AMP-binding; pfam00501 875328010012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328010013 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328010014 acyl-activating enzyme (AAE) consensus motif; other site 875328010015 acyl-activating enzyme (AAE) consensus motif; other site 875328010016 putative AMP binding site [chemical binding]; other site 875328010017 putative active site [active] 875328010018 putative CoA binding site [chemical binding]; other site 875328010019 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 875328010020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010022 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 875328010023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328010024 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328010025 acyl-activating enzyme (AAE) consensus motif; other site 875328010026 putative AMP binding site [chemical binding]; other site 875328010027 putative active site [active] 875328010028 putative CoA binding site [chemical binding]; other site 875328010029 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328010030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328010031 substrate binding site [chemical binding]; other site 875328010032 oxyanion hole (OAH) forming residues; other site 875328010033 trimer interface [polypeptide binding]; other site 875328010034 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 875328010035 mce related protein; Region: MCE; pfam02470 875328010036 mce related protein; Region: MCE; pfam02470 875328010037 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328010038 mce related protein; Region: MCE; pfam02470 875328010039 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328010040 mce related protein; Region: MCE; pfam02470 875328010041 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328010042 mce related protein; Region: MCE; pfam02470 875328010043 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 875328010044 mce related protein; Region: MCE; pfam02470 875328010045 Permease; Region: Permease; pfam02405 875328010046 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328010047 Permease; Region: Permease; pfam02405 875328010048 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328010049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328010050 Cytochrome P450; Region: p450; cl12078 875328010051 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 875328010052 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 875328010053 ligand binding site [chemical binding]; other site 875328010054 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328010055 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328010056 NAD(P) binding site [chemical binding]; other site 875328010057 catalytic residues [active] 875328010058 hypothetical protein; Provisional; Region: PRK05865 875328010059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010060 NAD(P) binding site [chemical binding]; other site 875328010061 active site 875328010062 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328010063 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 875328010064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328010065 motif II; other site 875328010066 FCD domain; Region: FCD; cl11656 875328010067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010068 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 875328010069 FAD binding site [chemical binding]; other site 875328010070 substrate binding site [chemical binding]; other site 875328010071 catalytic base [active] 875328010072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010073 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328010074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010075 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 875328010076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328010077 substrate binding site [chemical binding]; other site 875328010078 oxyanion hole (OAH) forming residues; other site 875328010079 trimer interface [polypeptide binding]; other site 875328010080 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 875328010081 short chain dehydrogenase; Provisional; Region: PRK07677 875328010082 NAD(P) binding site [chemical binding]; other site 875328010083 substrate binding site [chemical binding]; other site 875328010084 homotetramer interface [polypeptide binding]; other site 875328010085 active site 875328010086 homodimer interface [polypeptide binding]; other site 875328010087 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 875328010088 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 875328010089 acyl-activating enzyme (AAE) consensus motif; other site 875328010090 putative AMP binding site [chemical binding]; other site 875328010091 putative active site [active] 875328010092 putative CoA binding site [chemical binding]; other site 875328010093 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 875328010094 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328010095 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 875328010096 classical (c) SDRs; Region: SDR_c; cd05233 875328010097 NAD(P) binding site [chemical binding]; other site 875328010098 active site 875328010099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328010101 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328010102 PGAP1-like protein; Region: PGAP1; pfam07819 875328010103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010104 NAD(P) binding site [chemical binding]; other site 875328010105 active site 875328010106 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328010107 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 875328010108 NAD(P) binding site [chemical binding]; other site 875328010109 catalytic residues [active] 875328010110 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 875328010111 classical (c) SDRs; Region: SDR_c; cd05233 875328010112 NAD(P) binding site [chemical binding]; other site 875328010113 active site 875328010114 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328010115 active site 2 [active] 875328010116 active site 1 [active] 875328010117 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 875328010118 active site 2 [active] 875328010119 active site 1 [active] 875328010120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010121 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328010122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010125 active site 875328010126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010128 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 875328010129 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 875328010130 ligand binding site [chemical binding]; other site 875328010131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010132 hypothetical protein; Provisional; Region: PRK05865 875328010133 active site 875328010134 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 875328010135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328010137 NAD(P) binding site [chemical binding]; other site 875328010138 active site 875328010139 enoyl-CoA hydratase; Provisional; Region: PRK08252 875328010140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328010141 substrate binding site [chemical binding]; other site 875328010142 oxyanion hole (OAH) forming residues; other site 875328010143 trimer interface [polypeptide binding]; other site 875328010144 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 875328010145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328010146 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 875328010147 acyl-activating enzyme (AAE) consensus motif; other site 875328010148 acyl-activating enzyme (AAE) consensus motif; other site 875328010149 AMP binding site [chemical binding]; other site 875328010150 active site 875328010151 CoA binding site [chemical binding]; other site 875328010152 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 875328010153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010154 active site 875328010155 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010157 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 875328010158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328010159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 875328010160 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 875328010161 dimer interface [polypeptide binding]; other site 875328010162 active site 875328010163 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328010164 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328010165 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 875328010166 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328010167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010169 active site 875328010170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010172 active site 875328010173 enoyl-CoA hydratase; Provisional; Region: PRK06494 875328010174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328010175 substrate binding site [chemical binding]; other site 875328010176 oxyanion hole (OAH) forming residues; other site 875328010177 trimer interface [polypeptide binding]; other site 875328010178 Nitronate monooxygenase; Region: NMO; pfam03060 875328010179 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 875328010180 FMN binding site [chemical binding]; other site 875328010181 substrate binding site [chemical binding]; other site 875328010182 putative catalytic residue [active] 875328010183 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 875328010184 active site 875328010185 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 875328010186 DUF35 OB-fold domain; Region: DUF35; pfam01796 875328010187 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328010188 Transcriptional regulators [Transcription]; Region: FadR; COG2186 875328010189 FCD domain; Region: FCD; pfam07729 875328010190 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 875328010191 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 875328010192 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 875328010193 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 875328010194 active site 875328010195 Fe binding site [ion binding]; other site 875328010196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010197 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 875328010198 Flavin binding site [chemical binding]; other site 875328010199 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 875328010200 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 875328010201 FAD binding pocket [chemical binding]; other site 875328010202 FAD binding motif [chemical binding]; other site 875328010203 phosphate binding motif [ion binding]; other site 875328010204 beta-alpha-beta structure motif; other site 875328010205 NAD(p) ribose binding residues [chemical binding]; other site 875328010206 NAD binding pocket [chemical binding]; other site 875328010207 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 875328010208 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328010209 catalytic loop [active] 875328010210 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 875328010211 iron binding site [ion binding]; other site 875328010212 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 875328010213 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 875328010214 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 875328010215 catalytic site [active] 875328010216 active site 875328010217 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 875328010218 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 875328010219 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 875328010220 active site 875328010221 catalytic site [active] 875328010222 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 875328010223 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 875328010224 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 875328010225 active site 875328010226 catalytic site [active] 875328010227 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 875328010228 trehalose synthase; Region: treS_nterm; TIGR02456 875328010229 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 875328010230 active site 875328010231 catalytic site [active] 875328010232 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 875328010233 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 875328010234 glycogen branching enzyme; Provisional; Region: PRK05402 875328010235 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 875328010236 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 875328010237 active site 875328010238 catalytic site [active] 875328010239 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 875328010240 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 875328010241 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 875328010242 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 875328010243 active site 875328010244 homodimer interface [polypeptide binding]; other site 875328010245 catalytic site [active] 875328010246 acceptor binding site [chemical binding]; other site 875328010247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010248 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 875328010249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328010251 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328010252 active site 875328010253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010255 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 875328010256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 875328010257 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 875328010258 transmembrane helices; other site 875328010259 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 875328010260 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 875328010261 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 875328010262 active site 875328010263 catalytic site [active] 875328010264 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 875328010265 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 875328010266 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 875328010267 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 875328010268 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 875328010269 active site 875328010270 HIGH motif; other site 875328010271 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 875328010272 KMSKS motif; other site 875328010273 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 875328010274 tRNA binding surface [nucleotide binding]; other site 875328010275 anticodon binding site; other site 875328010276 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 875328010277 homotrimer interaction site [polypeptide binding]; other site 875328010278 zinc binding site [ion binding]; other site 875328010279 CDP-binding sites; other site 875328010280 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 875328010281 substrate binding site; other site 875328010282 dimer interface; other site 875328010283 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 875328010284 DNA repair protein RadA; Provisional; Region: PRK11823 875328010285 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 875328010286 Walker A motif; other site 875328010287 ATP binding site [chemical binding]; other site 875328010288 Walker B motif; other site 875328010289 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 875328010290 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 875328010291 active site clefts [active] 875328010292 zinc binding site [ion binding]; other site 875328010293 dimer interface [polypeptide binding]; other site 875328010294 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 875328010295 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 875328010296 minor groove reading motif; other site 875328010297 helix-hairpin-helix signature motif; other site 875328010298 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 875328010299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328010300 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 875328010301 catalytic site [active] 875328010302 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 875328010303 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 875328010304 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 875328010305 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 875328010306 Clp amino terminal domain; Region: Clp_N; pfam02861 875328010307 Clp amino terminal domain; Region: Clp_N; pfam02861 875328010308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328010309 Walker A motif; other site 875328010310 ATP binding site [chemical binding]; other site 875328010311 Walker B motif; other site 875328010312 arginine finger; other site 875328010313 UvrB/uvrC motif; Region: UVR; pfam02151 875328010314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328010315 Walker A motif; other site 875328010316 ATP binding site [chemical binding]; other site 875328010317 Walker B motif; other site 875328010318 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 875328010319 Lsr2; Region: Lsr2; pfam11774 875328010320 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 875328010321 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 875328010322 putative anticodon binding site; other site 875328010323 dimer interface [polypeptide binding]; other site 875328010324 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 875328010325 motif 1; other site 875328010326 dimer interface [polypeptide binding]; other site 875328010327 active site 875328010328 motif 2; other site 875328010329 motif 3; other site 875328010330 pantothenate kinase; Reviewed; Region: PRK13318 875328010331 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 875328010332 tetramerization interface [polypeptide binding]; other site 875328010333 active site 875328010334 Pantoate-beta-alanine ligase; Region: PanC; cd00560 875328010335 pantoate--beta-alanine ligase; Region: panC; TIGR00018 875328010336 active site 875328010337 ATP-binding site [chemical binding]; other site 875328010338 pantoate-binding site; other site 875328010339 HXXH motif; other site 875328010340 Rossmann-like domain; Region: Rossmann-like; pfam10727 875328010341 Uncharacterized conserved protein [Function unknown]; Region: COG5495 875328010342 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 875328010343 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 875328010344 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 875328010345 catalytic center binding site [active] 875328010346 ATP binding site [chemical binding]; other site 875328010347 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 875328010348 homooctamer interface [polypeptide binding]; other site 875328010349 active site 875328010350 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 875328010351 dihydropteroate synthase; Region: DHPS; TIGR01496 875328010352 substrate binding pocket [chemical binding]; other site 875328010353 dimer interface [polypeptide binding]; other site 875328010354 inhibitor binding site; inhibition site 875328010355 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 875328010356 homodecamer interface [polypeptide binding]; other site 875328010357 GTP cyclohydrolase I; Provisional; Region: PLN03044 875328010358 active site 875328010359 putative catalytic site residues [active] 875328010360 zinc binding site [ion binding]; other site 875328010361 GTP-CH-I/GFRP interaction surface; other site 875328010362 FtsH Extracellular; Region: FtsH_ext; pfam06480 875328010363 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 875328010364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328010365 Walker A motif; other site 875328010366 ATP binding site [chemical binding]; other site 875328010367 Walker B motif; other site 875328010368 arginine finger; other site 875328010369 Peptidase family M41; Region: Peptidase_M41; pfam01434 875328010370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328010371 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328010372 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328010373 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 875328010374 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 875328010375 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 875328010376 putative NAD(P) binding site [chemical binding]; other site 875328010377 catalytic Zn binding site [ion binding]; other site 875328010378 Uncharacterized conserved protein [Function unknown]; Region: COG2968 875328010379 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 875328010380 Transposase, Mutator family; Region: Transposase_mut; pfam00872 875328010381 MULE transposase domain; Region: MULE; pfam10551 875328010382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 875328010383 active site 875328010384 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 875328010385 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 875328010386 Ligand Binding Site [chemical binding]; other site 875328010387 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 875328010388 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 875328010389 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 875328010390 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 875328010391 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 875328010392 dimer interface [polypeptide binding]; other site 875328010393 substrate binding site [chemical binding]; other site 875328010394 metal binding sites [ion binding]; metal-binding site 875328010395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010397 Domain of unknown function (DUF385); Region: DUF385; cl04387 875328010398 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 875328010399 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 875328010400 Ligand binding site; other site 875328010401 Putative Catalytic site; other site 875328010402 DXD motif; other site 875328010403 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 875328010404 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 875328010405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 875328010406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 875328010407 motif II; other site 875328010408 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 875328010409 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 875328010410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328010411 NAD(P) binding site [chemical binding]; other site 875328010412 active site 875328010413 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 875328010414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328010415 acyl-activating enzyme (AAE) consensus motif; other site 875328010416 AMP binding site [chemical binding]; other site 875328010417 active site 875328010418 CoA binding site [chemical binding]; other site 875328010419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328010420 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 875328010421 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 875328010422 putative trimer interface [polypeptide binding]; other site 875328010423 putative CoA binding site [chemical binding]; other site 875328010424 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 875328010425 putative trimer interface [polypeptide binding]; other site 875328010426 putative CoA binding site [chemical binding]; other site 875328010427 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 875328010428 Zn binding site [ion binding]; other site 875328010429 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328010430 PPE family; Region: PPE; pfam00823 875328010431 Short C-terminal domain; Region: SHOCT; pfam09851 875328010432 PE family; Region: PE; pfam00934 875328010433 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328010434 PPE family; Region: PPE; pfam00823 875328010435 Short C-terminal domain; Region: SHOCT; pfam09851 875328010436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328010437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328010438 active site 875328010439 phosphorylation site [posttranslational modification] 875328010440 intermolecular recognition site; other site 875328010441 dimerization interface [polypeptide binding]; other site 875328010442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328010443 DNA binding site [nucleotide binding] 875328010444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328010445 dimer interface [polypeptide binding]; other site 875328010446 phosphorylation site [posttranslational modification] 875328010447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328010448 ATP binding site [chemical binding]; other site 875328010449 Mg2+ binding site [ion binding]; other site 875328010450 G-X-G motif; other site 875328010451 DNA polymerase III subunit delta'; Validated; Region: PRK07940 875328010452 DNA polymerase III subunit delta'; Validated; Region: PRK08485 875328010453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 875328010454 dimerization interface [polypeptide binding]; other site 875328010455 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 875328010456 cyclase homology domain; Region: CHD; cd07302 875328010457 nucleotidyl binding site; other site 875328010458 metal binding site [ion binding]; metal-binding site 875328010459 dimer interface [polypeptide binding]; other site 875328010460 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 875328010461 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 875328010462 active site 875328010463 interdomain interaction site; other site 875328010464 putative metal-binding site [ion binding]; other site 875328010465 nucleotide binding site [chemical binding]; other site 875328010466 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 875328010467 domain I; other site 875328010468 phosphate binding site [ion binding]; other site 875328010469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 875328010470 domain II; other site 875328010471 domain III; other site 875328010472 nucleotide binding site [chemical binding]; other site 875328010473 DNA binding groove [nucleotide binding] 875328010474 catalytic site [active] 875328010475 domain IV; other site 875328010476 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 875328010477 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 875328010478 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 875328010479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 875328010480 DNA-binding site [nucleotide binding]; DNA binding site 875328010481 RNA-binding motif; other site 875328010482 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 875328010483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 875328010484 ATP binding site [chemical binding]; other site 875328010485 putative Mg++ binding site [ion binding]; other site 875328010486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 875328010487 nucleotide binding region [chemical binding]; other site 875328010488 ATP-binding site [chemical binding]; other site 875328010489 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 875328010490 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 875328010491 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 875328010492 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 875328010493 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 875328010494 Walker A motif; other site 875328010495 hexamer interface [polypeptide binding]; other site 875328010496 ATP binding site [chemical binding]; other site 875328010497 Walker B motif; other site 875328010498 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 875328010499 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 875328010500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328010501 motif II; other site 875328010502 acetyl-CoA synthetase; Provisional; Region: PRK00174 875328010503 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 875328010504 active site 875328010505 CoA binding site [chemical binding]; other site 875328010506 acyl-activating enzyme (AAE) consensus motif; other site 875328010507 AMP binding site [chemical binding]; other site 875328010508 acetate binding site [chemical binding]; other site 875328010509 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 875328010510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328010511 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 875328010512 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 875328010513 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 875328010514 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 875328010515 putative active site [active] 875328010516 putative CoA binding site [chemical binding]; other site 875328010517 nudix motif; other site 875328010518 metal binding site [ion binding]; metal-binding site 875328010519 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 875328010520 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328010521 catalytic residues [active] 875328010522 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 875328010523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 875328010524 minor groove reading motif; other site 875328010525 helix-hairpin-helix signature motif; other site 875328010526 substrate binding pocket [chemical binding]; other site 875328010527 active site 875328010528 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 875328010529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 875328010530 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 875328010531 ligand binding site [chemical binding]; other site 875328010532 flexible hinge region; other site 875328010533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 875328010534 putative switch regulator; other site 875328010535 non-specific DNA interactions [nucleotide binding]; other site 875328010536 DNA binding site [nucleotide binding] 875328010537 sequence specific DNA binding site [nucleotide binding]; other site 875328010538 putative cAMP binding site [chemical binding]; other site 875328010539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328010540 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 875328010541 homotrimer interaction site [polypeptide binding]; other site 875328010542 putative active site [active] 875328010543 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 875328010544 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 875328010545 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 875328010546 P loop; other site 875328010547 Nucleotide binding site [chemical binding]; other site 875328010548 DTAP/Switch II; other site 875328010549 Switch I; other site 875328010550 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 875328010551 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 875328010552 DTAP/Switch II; other site 875328010553 Switch I; other site 875328010554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 875328010555 Transcription factor WhiB; Region: Whib; pfam02467 875328010556 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 875328010557 Transglycosylase; Region: Transgly; pfam00912 875328010558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 875328010559 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 875328010560 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 875328010561 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 875328010562 putative active site [active] 875328010563 putative metal binding site [ion binding]; other site 875328010564 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 875328010565 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 875328010566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328010567 catalytic residue [active] 875328010568 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 875328010569 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 875328010570 Yqey-like protein; Region: YqeY; cl17540 875328010571 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 875328010572 MoxR-like ATPases [General function prediction only]; Region: COG0714 875328010573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328010574 Walker A motif; other site 875328010575 ATP binding site [chemical binding]; other site 875328010576 Walker B motif; other site 875328010577 arginine finger; other site 875328010578 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 875328010579 Protein of unknown function DUF58; Region: DUF58; pfam01882 875328010580 Integral membrane protein DUF95; Region: DUF95; cl00572 875328010581 Predicted membrane protein/domain [Function unknown]; Region: COG1714 875328010582 Predicted transcriptional regulators [Transcription]; Region: COG1695 875328010583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 875328010584 dimerization interface [polypeptide binding]; other site 875328010585 putative DNA binding site [nucleotide binding]; other site 875328010586 putative Zn2+ binding site [ion binding]; other site 875328010587 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 875328010588 glycerol kinase; Provisional; Region: glpK; PRK00047 875328010589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 875328010590 nucleotide binding site [chemical binding]; other site 875328010591 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328010592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328010593 S-adenosylmethionine binding site [chemical binding]; other site 875328010594 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328010595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328010596 catalytic residue [active] 875328010597 Uncharacterized conserved protein [Function unknown]; Region: COG4301 875328010598 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 875328010599 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 875328010600 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 875328010601 putative active site [active] 875328010602 putative dimer interface [polypeptide binding]; other site 875328010603 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 875328010604 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 875328010605 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 875328010606 PknH-like extracellular domain; Region: PknH_C; pfam14032 875328010607 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 875328010608 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 875328010609 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 875328010610 tetramer interface [polypeptide binding]; other site 875328010611 heme binding pocket [chemical binding]; other site 875328010612 NADPH binding site [chemical binding]; other site 875328010613 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 875328010614 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 875328010615 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 875328010616 aspartate kinase; Reviewed; Region: PRK06635 875328010617 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 875328010618 putative nucleotide binding site [chemical binding]; other site 875328010619 putative catalytic residues [active] 875328010620 putative Mg ion binding site [ion binding]; other site 875328010621 putative aspartate binding site [chemical binding]; other site 875328010622 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 875328010623 putative allosteric regulatory site; other site 875328010624 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 875328010625 putative allosteric regulatory residue; other site 875328010626 2-isopropylmalate synthase; Validated; Region: PRK03739 875328010627 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 875328010628 active site 875328010629 catalytic residues [active] 875328010630 metal binding site [ion binding]; metal-binding site 875328010631 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 875328010632 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 875328010633 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 875328010634 active site 875328010635 catalytic site [active] 875328010636 substrate binding site [chemical binding]; other site 875328010637 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 875328010638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 875328010639 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 875328010640 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 875328010641 catalytic triad [active] 875328010642 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 875328010643 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 875328010644 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 875328010645 Fatty acid desaturase; Region: FA_desaturase; pfam00487 875328010646 Di-iron ligands [ion binding]; other site 875328010647 Rubredoxin [Energy production and conversion]; Region: COG1773 875328010648 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 875328010649 iron binding site [ion binding]; other site 875328010650 Rubredoxin [Energy production and conversion]; Region: COG1773 875328010651 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 875328010652 iron binding site [ion binding]; other site 875328010653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 875328010654 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 875328010655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328010656 recombination protein RecR; Reviewed; Region: recR; PRK00076 875328010657 RecR protein; Region: RecR; pfam02132 875328010658 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 875328010659 putative active site [active] 875328010660 putative metal-binding site [ion binding]; other site 875328010661 tetramer interface [polypeptide binding]; other site 875328010662 hypothetical protein; Validated; Region: PRK00153 875328010663 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 875328010664 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 875328010665 active site 875328010666 metal binding site [ion binding]; metal-binding site 875328010667 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 875328010668 FAD binding domain; Region: FAD_binding_4; pfam01565 875328010669 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328010670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328010671 hypothetical protein; Provisional; Region: PRK06185 875328010672 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 875328010673 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 875328010674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 875328010675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328010676 S-adenosylmethionine binding site [chemical binding]; other site 875328010677 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 875328010678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 875328010679 Walker A motif; other site 875328010680 ATP binding site [chemical binding]; other site 875328010681 Walker B motif; other site 875328010682 arginine finger; other site 875328010683 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 875328010684 CHAP domain; Region: CHAP; cl17642 875328010685 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 875328010686 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328010687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328010688 catalytic residue [active] 875328010689 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 875328010690 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 875328010691 Transport protein; Region: actII; TIGR00833 875328010692 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328010693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010695 Penicillinase repressor; Region: Pencillinase_R; pfam03965 875328010696 Peptidase family M48; Region: Peptidase_M48; cl12018 875328010697 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 875328010698 nucleotide binding site [chemical binding]; other site 875328010699 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 875328010700 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 875328010701 active site 875328010702 DNA binding site [nucleotide binding] 875328010703 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 875328010704 DNA binding site [nucleotide binding] 875328010705 haloalkane dehalogenase; Provisional; Region: PRK00870 875328010706 Domain of unknown function DUF302; Region: DUF302; pfam03625 875328010707 acyl-CoA synthetase; Validated; Region: PRK05850 875328010708 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328010709 acyl-activating enzyme (AAE) consensus motif; other site 875328010710 active site 875328010711 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 875328010712 nudix motif; other site 875328010713 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 875328010714 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 875328010715 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 875328010716 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 875328010717 active site 875328010718 metal binding site [ion binding]; metal-binding site 875328010719 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 875328010720 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 875328010721 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 875328010722 nucleoside/Zn binding site; other site 875328010723 dimer interface [polypeptide binding]; other site 875328010724 catalytic motif [active] 875328010725 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 875328010726 prephenate dehydrogenase; Validated; Region: PRK06545 875328010727 prephenate dehydrogenase; Validated; Region: PRK08507 875328010728 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 875328010729 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 875328010730 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328010731 catalytic core [active] 875328010732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 875328010733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 875328010734 dimerization interface [polypeptide binding]; other site 875328010735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 875328010736 dimer interface [polypeptide binding]; other site 875328010737 phosphorylation site [posttranslational modification] 875328010738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 875328010739 ATP binding site [chemical binding]; other site 875328010740 Mg2+ binding site [ion binding]; other site 875328010741 G-X-G motif; other site 875328010742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 875328010743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 875328010744 active site 875328010745 phosphorylation site [posttranslational modification] 875328010746 intermolecular recognition site; other site 875328010747 dimerization interface [polypeptide binding]; other site 875328010748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 875328010749 DNA binding site [nucleotide binding] 875328010750 Phosphotransferase enzyme family; Region: APH; pfam01636 875328010751 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 875328010752 putative active site [active] 875328010753 putative substrate binding site [chemical binding]; other site 875328010754 ATP binding site [chemical binding]; other site 875328010755 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 875328010756 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 875328010757 metal binding site [ion binding]; metal-binding site 875328010758 putative dimer interface [polypeptide binding]; other site 875328010759 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 875328010760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 875328010761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 875328010762 homodimer interface [polypeptide binding]; other site 875328010763 catalytic residue [active] 875328010764 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 875328010765 putative hydrophobic ligand binding site [chemical binding]; other site 875328010766 protein interface [polypeptide binding]; other site 875328010767 gate; other site 875328010768 GXWXG protein; Region: GXWXG; pfam14231 875328010769 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 875328010770 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 875328010771 TIGR03086 family protein; Region: TIGR03086 875328010772 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 875328010773 enoyl-CoA hydratase; Provisional; Region: PRK06142 875328010774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328010775 substrate binding site [chemical binding]; other site 875328010776 oxyanion hole (OAH) forming residues; other site 875328010777 trimer interface [polypeptide binding]; other site 875328010778 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 875328010779 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 875328010780 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 875328010781 active site 875328010782 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 875328010783 catalytic triad [active] 875328010784 dimer interface [polypeptide binding]; other site 875328010785 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328010786 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328010787 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328010788 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 875328010789 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 875328010790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 875328010791 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 875328010792 dimerization interface [polypeptide binding]; other site 875328010793 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 875328010794 GIY-YIG motif/motif A; other site 875328010795 putative active site [active] 875328010796 putative metal binding site [ion binding]; other site 875328010797 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 875328010798 putative active site [active] 875328010799 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 875328010800 Protein of unknown function (DUF433); Region: DUF433; pfam04255 875328010801 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 875328010802 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 875328010803 NAD(P) binding site [chemical binding]; other site 875328010804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 875328010805 non-specific DNA binding site [nucleotide binding]; other site 875328010806 salt bridge; other site 875328010807 sequence-specific DNA binding site [nucleotide binding]; other site 875328010808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 875328010809 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 875328010810 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328010811 acyl-CoA synthetase; Validated; Region: PRK05850 875328010812 acyl-activating enzyme (AAE) consensus motif; other site 875328010813 active site 875328010814 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 875328010815 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 875328010816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 875328010817 catalytic residue [active] 875328010818 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 875328010819 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 875328010820 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 875328010821 Walker A/P-loop; other site 875328010822 ATP binding site [chemical binding]; other site 875328010823 Q-loop/lid; other site 875328010824 ABC transporter signature motif; other site 875328010825 Walker B; other site 875328010826 D-loop; other site 875328010827 H-loop/switch region; other site 875328010828 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 875328010829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 875328010830 active site 875328010831 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 875328010832 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 875328010833 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 875328010834 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 875328010835 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 875328010836 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 875328010837 active site pocket [active] 875328010838 Predicted membrane protein [Function unknown]; Region: COG2246 875328010839 GtrA-like protein; Region: GtrA; pfam04138 875328010840 hypothetical protein; Provisional; Region: PRK13696 875328010841 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 875328010842 oligomeric interface; other site 875328010843 putative active site [active] 875328010844 homodimer interface [polypeptide binding]; other site 875328010845 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 875328010846 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 875328010847 putative active site [active] 875328010848 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 875328010849 FAD binding domain; Region: FAD_binding_4; pfam01565 875328010850 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 875328010851 short chain dehydrogenase; Provisional; Region: PRK07904 875328010852 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 875328010853 NAD(P) binding site [chemical binding]; other site 875328010854 active site 875328010855 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 875328010856 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 875328010857 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 875328010858 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 875328010859 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 875328010860 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 875328010861 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 875328010862 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 875328010863 Subunit I/III interface [polypeptide binding]; other site 875328010864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 875328010865 metabolite-proton symporter; Region: 2A0106; TIGR00883 875328010866 putative substrate translocation pore; other site 875328010867 PE-PPE domain; Region: PE-PPE; pfam08237 875328010868 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 875328010869 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 875328010870 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 875328010871 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 875328010872 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 875328010873 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328010874 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 875328010875 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 875328010876 active site 875328010877 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 875328010878 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 875328010879 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 875328010880 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 875328010881 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 875328010882 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 875328010883 acyl-activating enzyme (AAE) consensus motif; other site 875328010884 active site 875328010885 Cutinase; Region: Cutinase; pfam01083 875328010886 Predicted esterase [General function prediction only]; Region: COG0627 875328010887 Putative esterase; Region: Esterase; pfam00756 875328010888 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 875328010889 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 875328010890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 875328010891 active site 875328010892 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 875328010893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328010894 UDP-galactopyranose mutase; Region: GLF; pfam03275 875328010895 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 875328010896 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 875328010897 amidase catalytic site [active] 875328010898 Zn binding residues [ion binding]; other site 875328010899 substrate binding site [chemical binding]; other site 875328010900 LGFP repeat; Region: LGFP; pfam08310 875328010901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 875328010902 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 875328010903 active site 875328010904 motif I; other site 875328010905 motif II; other site 875328010906 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 875328010907 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 875328010908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328010909 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328010910 putative acyl-acceptor binding pocket; other site 875328010911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328010912 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328010913 putative acyl-acceptor binding pocket; other site 875328010914 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 875328010915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 875328010916 putative acyl-acceptor binding pocket; other site 875328010917 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 875328010918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 875328010919 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 875328010920 iron-sulfur cluster [ion binding]; other site 875328010921 [2Fe-2S] cluster binding site [ion binding]; other site 875328010922 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 875328010923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328010924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010926 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 875328010927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010929 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 875328010930 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328010931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010933 seryl-tRNA synthetase; Provisional; Region: PRK05431 875328010934 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 875328010935 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 875328010936 dimer interface [polypeptide binding]; other site 875328010937 active site 875328010938 motif 1; other site 875328010939 motif 2; other site 875328010940 motif 3; other site 875328010941 Septum formation; Region: Septum_form; pfam13845 875328010942 Septum formation; Region: Septum_form; pfam13845 875328010943 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 875328010944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 875328010945 catalytic core [active] 875328010946 prephenate dehydratase; Provisional; Region: PRK11898 875328010947 Prephenate dehydratase; Region: PDT; pfam00800 875328010948 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 875328010949 putative L-Phe binding site [chemical binding]; other site 875328010950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 875328010951 CAAX protease self-immunity; Region: Abi; pfam02517 875328010952 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 875328010953 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 875328010954 Transcriptional regulator [Transcription]; Region: LytR; COG1316 875328010955 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 875328010956 Ferritin-like domain; Region: Ferritin; pfam00210 875328010957 ferroxidase diiron center [ion binding]; other site 875328010958 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 875328010959 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 875328010960 putative active site [active] 875328010961 catalytic site [active] 875328010962 putative metal binding site [ion binding]; other site 875328010963 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 875328010964 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 875328010965 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 875328010966 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 875328010967 Predicted membrane protein [Function unknown]; Region: COG2119 875328010968 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 875328010969 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 875328010970 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 875328010971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 875328010972 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 875328010973 CopC domain; Region: CopC; pfam04234 875328010974 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 875328010975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 875328010976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 875328010977 catalytic residue [active] 875328010978 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328010979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328010980 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328010981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328010982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328010983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328010984 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 875328010985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 875328010986 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 875328010987 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 875328010988 active site 875328010989 dimer interface [polypeptide binding]; other site 875328010990 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 875328010991 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 875328010992 active site 875328010993 FMN binding site [chemical binding]; other site 875328010994 substrate binding site [chemical binding]; other site 875328010995 3Fe-4S cluster binding site [ion binding]; other site 875328010996 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 875328010997 domain interface; other site 875328010998 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 875328010999 glutamine synthetase, type I; Region: GlnA; TIGR00653 875328011000 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 875328011001 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 875328011002 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 875328011003 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 875328011004 putative active site [active] 875328011005 putative catalytic site [active] 875328011006 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 875328011007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 875328011008 Putative esterase; Region: Esterase; pfam00756 875328011009 Predicted membrane protein [Function unknown]; Region: COG3619 875328011010 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 875328011011 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 875328011012 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 875328011013 elongation factor G; Reviewed; Region: PRK12740 875328011014 G1 box; other site 875328011015 GTP/Mg2+ binding site [chemical binding]; other site 875328011016 G2 box; other site 875328011017 Switch I region; other site 875328011018 G3 box; other site 875328011019 Switch II region; other site 875328011020 G4 box; other site 875328011021 G5 box; other site 875328011022 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 875328011023 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 875328011024 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 875328011025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 875328011026 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 875328011027 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 875328011028 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 875328011029 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328011030 acyl-activating enzyme (AAE) consensus motif; other site 875328011031 AMP binding site [chemical binding]; other site 875328011032 active site 875328011033 CoA binding site [chemical binding]; other site 875328011034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 875328011035 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 875328011036 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 875328011037 putative NAD(P) binding site [chemical binding]; other site 875328011038 active site 875328011039 putative substrate binding site [chemical binding]; other site 875328011040 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 875328011041 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 875328011042 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 875328011043 active site 875328011044 catalytic triad [active] 875328011045 oxyanion hole [active] 875328011046 Rhomboid family; Region: Rhomboid; pfam01694 875328011047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 875328011048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 875328011049 S-adenosylmethionine binding site [chemical binding]; other site 875328011050 Protein of unknown function (DUF732); Region: DUF732; pfam05305 875328011051 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328011052 PPE family; Region: PPE; pfam00823 875328011053 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328011054 PPE family; Region: PPE; pfam00823 875328011055 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 875328011056 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 875328011057 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 875328011058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328011059 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328011060 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328011061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328011062 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328011063 NAD(P) binding site [chemical binding]; other site 875328011064 catalytic residues [active] 875328011065 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 875328011066 hydrophobic ligand binding site; other site 875328011067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328011068 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 875328011069 DNA-binding interface [nucleotide binding]; DNA binding site 875328011070 short chain dehydrogenase; Provisional; Region: PRK06197 875328011071 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 875328011072 putative NAD(P) binding site [chemical binding]; other site 875328011073 active site 875328011074 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 875328011075 Cytochrome P450; Region: p450; cl12078 875328011076 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 875328011077 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 875328011078 putative hydrophobic ligand binding site [chemical binding]; other site 875328011079 protein interface [polypeptide binding]; other site 875328011080 gate; other site 875328011081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328011082 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 875328011083 active site 875328011084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 875328011085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328011086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328011087 Epoxide hydrolase N terminus; Region: EHN; pfam06441 875328011088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328011089 Domain of unknown function (DUF222); Region: DUF222; pfam02720 875328011090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 875328011091 active site 875328011092 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328011093 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 875328011094 [2Fe-2S] cluster binding site [ion binding]; other site 875328011095 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 875328011096 putative alpha subunit interface [polypeptide binding]; other site 875328011097 putative active site [active] 875328011098 putative substrate binding site [chemical binding]; other site 875328011099 Fe binding site [ion binding]; other site 875328011100 Transport protein; Region: actII; TIGR00833 875328011101 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 875328011102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328011103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328011104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328011105 active site 875328011106 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328011107 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328011108 Amidohydrolase; Region: Amidohydro_2; pfam04909 875328011109 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 875328011110 classical (c) SDRs; Region: SDR_c; cd05233 875328011111 NAD(P) binding site [chemical binding]; other site 875328011112 active site 875328011113 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 875328011114 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328011115 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 875328011116 hydrophobic ligand binding site; other site 875328011117 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 875328011118 active site 875328011119 catalytic site [active] 875328011120 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 875328011121 active site 875328011122 catalytic site [active] 875328011123 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 875328011124 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 875328011125 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 875328011126 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328011127 short chain dehydrogenase; Provisional; Region: PRK07454 875328011128 classical (c) SDRs; Region: SDR_c; cd05233 875328011129 NAD(P) binding site [chemical binding]; other site 875328011130 active site 875328011131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 875328011132 PE family; Region: PE; pfam00934 875328011133 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 875328011134 PPE family; Region: PPE; pfam00823 875328011135 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 875328011136 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 875328011137 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328011138 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 875328011139 classical (c) SDRs; Region: SDR_c; cd05233 875328011140 NAD(P) binding site [chemical binding]; other site 875328011141 active site 875328011142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328011143 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 875328011144 NAD(P) binding site [chemical binding]; other site 875328011145 catalytic residues [active] 875328011146 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 875328011147 dimer interface [polypeptide binding]; other site 875328011148 substrate binding site [chemical binding]; other site 875328011149 metal binding site [ion binding]; metal-binding site 875328011150 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 875328011151 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 875328011152 active site 875328011153 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 875328011154 catalytic triad [active] 875328011155 dimer interface [polypeptide binding]; other site 875328011156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328011157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 875328011158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328011159 NAD(P) binding site [chemical binding]; other site 875328011160 active site 875328011161 classical (c) SDRs; Region: SDR_c; cd05233 875328011162 NAD(P) binding site [chemical binding]; other site 875328011163 active site 875328011164 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328011165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328011166 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 875328011167 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 875328011168 FAD binding pocket [chemical binding]; other site 875328011169 FAD binding motif [chemical binding]; other site 875328011170 phosphate binding motif [ion binding]; other site 875328011171 beta-alpha-beta structure motif; other site 875328011172 NAD(p) ribose binding residues [chemical binding]; other site 875328011173 NAD binding pocket [chemical binding]; other site 875328011174 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 875328011175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 875328011176 catalytic loop [active] 875328011177 iron binding site [ion binding]; other site 875328011178 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328011179 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328011180 active site 875328011181 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 875328011182 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 875328011183 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 875328011184 active site 875328011185 Fe binding site [ion binding]; other site 875328011186 hypothetical protein; Validated; Region: PRK07121 875328011187 Transcriptional regulator [Transcription]; Region: IclR; COG1414 875328011188 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 875328011189 Bacterial transcriptional regulator; Region: IclR; pfam01614 875328011190 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328011191 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328011192 substrate binding pocket [chemical binding]; other site 875328011193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 875328011194 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 875328011195 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 875328011196 active site 875328011197 FMN binding site [chemical binding]; other site 875328011198 substrate binding site [chemical binding]; other site 875328011199 putative catalytic residue [active] 875328011200 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 875328011201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 875328011202 NAD(P) binding site [chemical binding]; other site 875328011203 active site 875328011204 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 875328011205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 875328011206 acyl-CoA synthetase; Validated; Region: PRK08316 875328011207 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 875328011208 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 875328011209 acyl-activating enzyme (AAE) consensus motif; other site 875328011210 acyl-activating enzyme (AAE) consensus motif; other site 875328011211 putative AMP binding site [chemical binding]; other site 875328011212 putative active site [active] 875328011213 putative CoA binding site [chemical binding]; other site 875328011214 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 875328011215 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 875328011216 structural Zn binding site [ion binding]; other site 875328011217 tetramer interface [polypeptide binding]; other site 875328011218 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 875328011219 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 875328011220 NAD binding site [chemical binding]; other site 875328011221 catalytic residues [active] 875328011222 enoyl-CoA hydratase; Validated; Region: PRK08139 875328011223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 875328011224 substrate binding site [chemical binding]; other site 875328011225 oxyanion hole (OAH) forming residues; other site 875328011226 trimer interface [polypeptide binding]; other site 875328011227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328011228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 875328011229 active site 875328011230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 875328011231 SnoaL-like domain; Region: SnoaL_4; cl17707 875328011232 classical (c) SDRs; Region: SDR_c; cd05233 875328011233 NAD(P) binding site [chemical binding]; other site 875328011234 active site 875328011235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 875328011236 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 875328011237 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 875328011238 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 875328011239 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 875328011240 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328011241 Predicted transcriptional regulators [Transcription]; Region: COG1695 875328011242 Transcriptional regulator PadR-like family; Region: PadR; cl17335 875328011243 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 875328011244 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 875328011245 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 875328011246 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 875328011247 CoenzymeA binding site [chemical binding]; other site 875328011248 subunit interaction site [polypeptide binding]; other site 875328011249 PHB binding site; other site 875328011250 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328011251 mce related protein; Region: MCE; pfam02470 875328011252 mce related protein; Region: MCE; pfam02470 875328011253 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328011254 mce related protein; Region: MCE; pfam02470 875328011255 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328011256 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328011257 mce related protein; Region: MCE; pfam02470 875328011258 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 875328011259 mce related protein; Region: MCE; pfam02470 875328011260 mce related protein; Region: MCE; pfam02470 875328011261 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 875328011262 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328011263 Permease; Region: Permease; pfam02405 875328011264 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 875328011265 Permease; Region: Permease; pfam02405 875328011266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 875328011267 classical (c) SDRs; Region: SDR_c; cd05233 875328011268 NAD(P) binding site [chemical binding]; other site 875328011269 active site 875328011270 Protein of unknown function (DUF422); Region: DUF422; cl00991 875328011271 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 875328011272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 875328011273 Uncharacterized conserved protein [Function unknown]; Region: COG3379 875328011274 Sulfatase; Region: Sulfatase; cl17466 875328011275 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 875328011276 active site 875328011277 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 875328011278 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 875328011279 PE-PPE domain; Region: PE-PPE; pfam08237 875328011280 PE-PPE domain; Region: PE-PPE; pfam08237 875328011281 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 875328011282 Mechanosensitive ion channel; Region: MS_channel; pfam00924 875328011283 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 875328011284 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 875328011285 Beta-lactamase; Region: Beta-lactamase; pfam00144 875328011286 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 875328011287 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 875328011288 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 875328011289 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 875328011290 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 875328011291 replicative DNA helicase; Region: DnaB; TIGR00665 875328011292 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 875328011293 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 875328011294 Walker A motif; other site 875328011295 ATP binding site [chemical binding]; other site 875328011296 Walker B motif; other site 875328011297 DNA binding loops [nucleotide binding] 875328011298 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 875328011299 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 875328011300 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 875328011301 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 875328011302 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 875328011303 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 875328011304 dimer interface [polypeptide binding]; other site 875328011305 ssDNA binding site [nucleotide binding]; other site 875328011306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 875328011307 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 875328011308 Predicted integral membrane protein [Function unknown]; Region: COG5650 875328011309 Transglycosylase; Region: Transgly; pfam00912 875328011310 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 875328011311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 875328011312 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 875328011313 Transglycosylase; Region: Transgly; pfam00912 875328011314 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 875328011315 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 875328011316 Predicted transcriptional regulators [Transcription]; Region: COG1695 875328011317 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 875328011318 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 875328011319 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 875328011320 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 875328011321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 875328011322 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 875328011323 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 875328011324 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 875328011325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 875328011326 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 875328011327 substrate binding pocket [chemical binding]; other site 875328011328 membrane-bound complex binding site; other site 875328011329 hinge residues; other site 875328011330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 875328011331 ABC-ATPase subunit interface; other site 875328011332 putative PBP binding loops; other site 875328011333 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 875328011334 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 875328011335 Walker A/P-loop; other site 875328011336 ATP binding site [chemical binding]; other site 875328011337 Q-loop/lid; other site 875328011338 ABC transporter signature motif; other site 875328011339 Walker B; other site 875328011340 D-loop; other site 875328011341 H-loop/switch region; other site 875328011342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 875328011343 MarR family; Region: MarR; pfam01047 875328011344 short chain dehydrogenase; Provisional; Region: PRK08219 875328011345 classical (c) SDRs; Region: SDR_c; cd05233 875328011346 NAD(P) binding site [chemical binding]; other site 875328011347 active site 875328011348 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 875328011349 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328011350 active site 875328011351 HIGH motif; other site 875328011352 nucleotide binding site [chemical binding]; other site 875328011353 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 875328011354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 875328011355 active site 875328011356 KMSKS motif; other site 875328011357 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 875328011358 tRNA binding surface [nucleotide binding]; other site 875328011359 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 875328011360 hypothetical protein; Validated; Region: PRK00228 875328011361 H+ Antiporter protein; Region: 2A0121; TIGR00900 875328011362 TIGR03084 family protein; Region: TIGR03084 875328011363 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 875328011364 Wyosine base formation; Region: Wyosine_form; pfam08608 875328011365 PE-PPE domain; Region: PE-PPE; pfam08237 875328011366 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 875328011367 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 875328011368 active site 875328011369 NTP binding site [chemical binding]; other site 875328011370 metal binding triad [ion binding]; metal-binding site 875328011371 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 875328011372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 875328011373 Zn2+ binding site [ion binding]; other site 875328011374 Mg2+ binding site [ion binding]; other site 875328011375 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 875328011376 active site 875328011377 Ap6A binding site [chemical binding]; other site 875328011378 nudix motif; other site 875328011379 metal binding site [ion binding]; metal-binding site 875328011380 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 875328011381 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 875328011382 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 875328011383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 875328011384 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 875328011385 DNA binding residues [nucleotide binding] 875328011386 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 875328011387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 875328011388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 875328011389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 875328011390 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 875328011391 catalytic residues [active] 875328011392 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 875328011393 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 875328011394 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 875328011395 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 875328011396 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 875328011397 active site 875328011398 metal binding site [ion binding]; metal-binding site 875328011399 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 875328011400 ParB-like nuclease domain; Region: ParBc; pfam02195 875328011401 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 875328011402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328011403 P-loop; other site 875328011404 Magnesium ion binding site [ion binding]; other site 875328011405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 875328011406 Magnesium ion binding site [ion binding]; other site 875328011407 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 875328011408 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 875328011409 G-X-X-G motif; other site 875328011410 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 875328011411 RxxxH motif; other site 875328011412 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 875328011413 Ribonuclease P; Region: Ribonuclease_P; cl00457 875328011414 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399