-- dump date 20140619_152659 -- class Genbank::misc_feature -- table misc_feature_note -- id note 164757000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 164757000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757000003 Walker A motif; other site 164757000004 ATP binding site [chemical binding]; other site 164757000005 Walker B motif; other site 164757000006 arginine finger; other site 164757000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 164757000008 DnaA box-binding interface [nucleotide binding]; other site 164757000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 164757000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 164757000011 putative DNA binding surface [nucleotide binding]; other site 164757000012 dimer interface [polypeptide binding]; other site 164757000013 beta-clamp/clamp loader binding surface; other site 164757000014 beta-clamp/translesion DNA polymerase binding surface; other site 164757000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 164757000017 recombination protein F; Reviewed; Region: recF; PRK00064 164757000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 164757000019 Walker A/P-loop; other site 164757000020 ATP binding site [chemical binding]; other site 164757000021 Q-loop/lid; other site 164757000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757000023 ABC transporter signature motif; other site 164757000024 Walker B; other site 164757000025 D-loop; other site 164757000026 H-loop/switch region; other site 164757000027 hypothetical protein; Provisional; Region: PRK03195 164757000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 164757000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757000030 Mg2+ binding site [ion binding]; other site 164757000031 G-X-G motif; other site 164757000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 164757000033 anchoring element; other site 164757000034 dimer interface [polypeptide binding]; other site 164757000035 ATP binding site [chemical binding]; other site 164757000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 164757000037 active site 164757000038 putative metal-binding site [ion binding]; other site 164757000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 164757000040 DNA gyrase subunit A; Validated; Region: PRK05560 164757000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 164757000042 CAP-like domain; other site 164757000043 active site 164757000044 primary dimer interface [polypeptide binding]; other site 164757000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 164757000052 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 164757000053 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 164757000054 active site 164757000055 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 164757000056 putative septation inhibitor protein; Reviewed; Region: PRK00159 164757000057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 164757000058 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 164757000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 164757000060 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 164757000061 glutamine binding [chemical binding]; other site 164757000062 catalytic triad [active] 164757000063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757000064 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757000065 active site 164757000066 ATP binding site [chemical binding]; other site 164757000067 substrate binding site [chemical binding]; other site 164757000068 activation loop (A-loop); other site 164757000069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 164757000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757000074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757000075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757000076 active site 164757000077 ATP binding site [chemical binding]; other site 164757000078 substrate binding site [chemical binding]; other site 164757000079 activation loop (A-loop); other site 164757000080 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 164757000081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 164757000082 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 164757000083 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 164757000084 active site 164757000085 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757000086 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757000087 phosphopeptide binding site; other site 164757000088 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 164757000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757000090 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757000091 phosphopeptide binding site; other site 164757000092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757000093 Walker A/P-loop; other site 164757000094 ATP binding site [chemical binding]; other site 164757000095 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757000096 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757000097 active site 164757000098 catalytic tetrad [active] 164757000099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000101 hypothetical protein; Validated; Region: PRK07581 164757000102 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 164757000103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000105 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 164757000106 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 164757000107 putative NADP binding site [chemical binding]; other site 164757000108 putative substrate binding site [chemical binding]; other site 164757000109 active site 164757000110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000112 active site 164757000113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000115 active site 164757000116 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 164757000117 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757000118 active site 164757000119 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757000120 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757000121 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757000122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000123 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 164757000124 NAD(P) binding site [chemical binding]; other site 164757000125 active site 164757000126 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 164757000127 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 164757000128 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 164757000129 DNA binding residues [nucleotide binding] 164757000130 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 164757000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757000132 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757000133 phosphopeptide binding site; other site 164757000134 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757000135 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757000136 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757000137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757000138 PHB binding site; other site 164757000139 CoenzymeA binding site [chemical binding]; other site 164757000140 subunit interaction site [polypeptide binding]; other site 164757000141 Predicted acetyltransferase [General function prediction only]; Region: COG2388 164757000142 hypothetical protein; Provisional; Region: PRK02268 164757000143 DivIVA domain; Region: DivI1A_domain; TIGR03544 164757000144 DivIVA domain; Region: DivI1A_domain; TIGR03544 164757000145 Transcription factor WhiB; Region: Whib; pfam02467 164757000146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757000147 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 164757000148 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 164757000149 EspG family; Region: ESX-1_EspG; pfam14011 164757000150 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 164757000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757000152 Walker A motif; other site 164757000153 ATP binding site [chemical binding]; other site 164757000154 Walker B motif; other site 164757000155 arginine finger; other site 164757000156 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 164757000157 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 164757000158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757000159 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 164757000160 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757000161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757000162 Walker A motif; other site 164757000163 ATP binding site [chemical binding]; other site 164757000164 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 164757000165 PPE family; Region: PPE; pfam00823 164757000166 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 164757000167 Proteins of 100 residues with WXG; Region: WXG100; cl02005 164757000168 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 164757000169 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 164757000170 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 164757000171 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 164757000172 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 164757000173 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 164757000174 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 164757000175 active site 164757000176 catalytic residues [active] 164757000177 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 164757000178 dimerization domain swap beta strand [polypeptide binding]; other site 164757000179 regulatory protein interface [polypeptide binding]; other site 164757000180 active site 164757000181 regulatory phosphorylation site [posttranslational modification]; other site 164757000182 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 164757000183 active site 164757000184 phosphorylation site [posttranslational modification] 164757000185 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 164757000186 active site 164757000187 P-loop; other site 164757000188 phosphorylation site [posttranslational modification] 164757000189 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 164757000190 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 164757000191 putative substrate binding site [chemical binding]; other site 164757000192 putative ATP binding site [chemical binding]; other site 164757000193 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 164757000194 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 164757000195 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 164757000196 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 164757000197 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 164757000198 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 164757000199 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 164757000200 Pirin-related protein [General function prediction only]; Region: COG1741 164757000201 Pirin; Region: Pirin; pfam02678 164757000202 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 164757000203 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 164757000204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000208 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757000209 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 164757000210 Leucine carboxyl methyltransferase; Region: LCM; cl01306 164757000211 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757000212 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 164757000213 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 164757000214 NAD(P) binding site [chemical binding]; other site 164757000215 catalytic residues [active] 164757000216 short chain dehydrogenase; Provisional; Region: PRK07791 164757000217 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 164757000218 NAD binding site [chemical binding]; other site 164757000219 homodimer interface [polypeptide binding]; other site 164757000220 active site 164757000221 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757000222 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 164757000223 NAD(P) binding site [chemical binding]; other site 164757000224 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 164757000225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757000226 motif II; other site 164757000227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757000228 S-adenosylmethionine binding site [chemical binding]; other site 164757000229 Protein of unknown function (DUF456); Region: DUF456; pfam04306 164757000230 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 164757000231 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 164757000232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000234 active site 164757000235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000237 active site 164757000238 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 164757000239 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 164757000240 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 164757000241 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 164757000242 ligand binding site [chemical binding]; other site 164757000243 homodimer interface [polypeptide binding]; other site 164757000244 NAD(P) binding site [chemical binding]; other site 164757000245 trimer interface B [polypeptide binding]; other site 164757000246 trimer interface A [polypeptide binding]; other site 164757000247 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 164757000248 short chain dehydrogenase; Provisional; Region: PRK07806 164757000249 glucose-1-dehydrogenase; Provisional; Region: PRK06947 164757000250 NAD(P) binding site [chemical binding]; other site 164757000251 active site 164757000252 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 164757000253 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 164757000254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757000255 dimer interface [polypeptide binding]; other site 164757000256 conserved gate region; other site 164757000257 putative PBP binding loops; other site 164757000258 ABC-ATPase subunit interface; other site 164757000259 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 164757000260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757000261 substrate binding pocket [chemical binding]; other site 164757000262 membrane-bound complex binding site; other site 164757000263 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 164757000264 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 164757000265 Walker A/P-loop; other site 164757000266 ATP binding site [chemical binding]; other site 164757000267 Q-loop/lid; other site 164757000268 ABC transporter signature motif; other site 164757000269 Walker B; other site 164757000270 D-loop; other site 164757000271 H-loop/switch region; other site 164757000272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000274 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 164757000275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000276 NAD(P) binding site [chemical binding]; other site 164757000277 active site 164757000278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000279 active site 164757000280 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 164757000281 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 164757000282 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757000283 NAD(P) binding site [chemical binding]; other site 164757000284 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 164757000285 active site 164757000286 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757000287 putative hydrophobic ligand binding site [chemical binding]; other site 164757000288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757000289 DNA-binding site [nucleotide binding]; DNA binding site 164757000290 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 164757000291 FCD domain; Region: FCD; pfam07729 164757000292 Restriction endonuclease; Region: Mrr_cat; pfam04471 164757000293 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 164757000294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757000295 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757000296 acyl-activating enzyme (AAE) consensus motif; other site 164757000297 putative AMP binding site [chemical binding]; other site 164757000298 putative active site [active] 164757000299 putative CoA binding site [chemical binding]; other site 164757000300 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757000301 Permease; Region: Permease; pfam02405 164757000302 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757000303 Permease; Region: Permease; pfam02405 164757000304 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000305 mce related protein; Region: MCE; pfam02470 164757000306 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757000307 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000308 mce related protein; Region: MCE; pfam02470 164757000309 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757000310 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000311 mce related protein; Region: MCE; pfam02470 164757000312 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757000313 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 164757000314 mce related protein; Region: MCE; pfam02470 164757000315 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000316 mce related protein; Region: MCE; pfam02470 164757000317 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000318 mce related protein; Region: MCE; pfam02470 164757000319 RDD family; Region: RDD; pfam06271 164757000320 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 164757000321 Phosphotransferase enzyme family; Region: APH; pfam01636 164757000322 Fructosamine kinase; Region: Fructosamin_kin; cl17579 164757000323 PE-PPE domain; Region: PE-PPE; pfam08237 164757000324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757000325 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 164757000326 Predicted membrane protein [Function unknown]; Region: COG2261 164757000327 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 164757000328 Pirin-related protein [General function prediction only]; Region: COG1741 164757000329 Pirin; Region: Pirin; pfam02678 164757000330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757000331 MarR family; Region: MarR_2; pfam12802 164757000332 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757000333 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757000334 NAD binding site [chemical binding]; other site 164757000335 catalytic Zn binding site [ion binding]; other site 164757000336 substrate binding site [chemical binding]; other site 164757000337 structural Zn binding site [ion binding]; other site 164757000338 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 164757000339 putative active site [active] 164757000340 RNA polymerase factor sigma-70; Validated; Region: PRK08241 164757000341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757000342 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757000343 DNA binding residues [nucleotide binding] 164757000344 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757000345 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 164757000346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757000347 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 164757000348 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 164757000349 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 164757000350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757000351 S-adenosylmethionine binding site [chemical binding]; other site 164757000352 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757000353 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 164757000354 Domain of unknown function (DUF305); Region: DUF305; pfam03713 164757000355 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757000356 putative homodimer interface [polypeptide binding]; other site 164757000357 putative homotetramer interface [polypeptide binding]; other site 164757000358 putative allosteric switch controlling residues; other site 164757000359 putative metal binding site [ion binding]; other site 164757000360 putative homodimer-homodimer interface [polypeptide binding]; other site 164757000361 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 164757000362 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 164757000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757000364 putative substrate translocation pore; other site 164757000365 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757000366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757000367 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757000368 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 164757000369 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757000370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757000371 Walker A motif; other site 164757000372 ATP binding site [chemical binding]; other site 164757000373 Walker B motif; other site 164757000374 arginine finger; other site 164757000375 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 164757000376 Protein of unknown function DUF58; Region: DUF58; pfam01882 164757000377 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 164757000378 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 164757000379 active site 164757000380 Zn binding site [ion binding]; other site 164757000381 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 164757000382 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 164757000383 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 164757000384 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 164757000385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757000386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757000387 active site 164757000388 phosphorylation site [posttranslational modification] 164757000389 intermolecular recognition site; other site 164757000390 dimerization interface [polypeptide binding]; other site 164757000391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757000392 DNA binding site [nucleotide binding] 164757000393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757000394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757000395 phosphorylation site [posttranslational modification] 164757000396 dimer interface [polypeptide binding]; other site 164757000397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757000398 ATP binding site [chemical binding]; other site 164757000399 Mg2+ binding site [ion binding]; other site 164757000400 G-X-G motif; other site 164757000401 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 164757000402 Predicted integral membrane protein [Function unknown]; Region: COG0392 164757000403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 164757000404 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 164757000405 MMPL family; Region: MMPL; pfam03176 164757000406 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 164757000407 MMPL family; Region: MMPL; pfam03176 164757000408 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 164757000409 LabA_like proteins; Region: LabA_like; cd06167 164757000410 putative metal binding site [ion binding]; other site 164757000411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757000412 S-adenosylmethionine binding site [chemical binding]; other site 164757000413 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 164757000414 active site 164757000415 substrate-binding site [chemical binding]; other site 164757000416 metal-binding site [ion binding] 164757000417 GTP binding site [chemical binding]; other site 164757000418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757000419 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 164757000420 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757000421 acyl-activating enzyme (AAE) consensus motif; other site 164757000422 putative AMP binding site [chemical binding]; other site 164757000423 putative active site [active] 164757000424 acyl-activating enzyme (AAE) consensus motif; other site 164757000425 putative CoA binding site [chemical binding]; other site 164757000426 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757000427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757000428 substrate binding site [chemical binding]; other site 164757000429 oxyanion hole (OAH) forming residues; other site 164757000430 trimer interface [polypeptide binding]; other site 164757000431 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 164757000432 classical (c) SDRs; Region: SDR_c; cd05233 164757000433 NAD(P) binding site [chemical binding]; other site 164757000434 active site 164757000435 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 164757000436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 164757000437 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 164757000438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000440 active site 164757000441 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 164757000442 putative active site [active] 164757000443 putative catalytic site [active] 164757000444 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757000445 active site 2 [active] 164757000446 active site 1 [active] 164757000447 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757000448 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 164757000449 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757000450 active site 164757000451 Ion channel; Region: Ion_trans_2; pfam07885 164757000452 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 164757000453 tetramer interface [polypeptide binding]; other site 164757000454 active site 164757000455 Mg2+/Mn2+ binding site [ion binding]; other site 164757000456 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 164757000457 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757000458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000459 NAD(P) binding site [chemical binding]; other site 164757000460 active site 164757000461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757000462 DNA-binding site [nucleotide binding]; DNA binding site 164757000463 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 164757000464 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 164757000465 short chain dehydrogenase; Provisional; Region: PRK12829 164757000466 classical (c) SDRs; Region: SDR_c; cd05233 164757000467 NAD(P) binding site [chemical binding]; other site 164757000468 active site 164757000469 Phosphotransferase enzyme family; Region: APH; pfam01636 164757000470 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 164757000471 substrate binding site [chemical binding]; other site 164757000472 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 164757000473 putative hexamer interface [polypeptide binding]; other site 164757000474 putative hexagonal pore; other site 164757000475 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 164757000476 putative hexamer interface [polypeptide binding]; other site 164757000477 putative hexagonal pore; other site 164757000478 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 164757000479 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 164757000480 Hexamer interface [polypeptide binding]; other site 164757000481 Hexagonal pore residue; other site 164757000482 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 164757000483 Hexamer/Pentamer interface [polypeptide binding]; other site 164757000484 central pore; other site 164757000485 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 164757000486 putative hexamer interface [polypeptide binding]; other site 164757000487 putative hexagonal pore; other site 164757000488 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 164757000489 putative hexamer interface [polypeptide binding]; other site 164757000490 putative hexagonal pore; other site 164757000491 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 164757000492 putative catalytic cysteine [active] 164757000493 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 164757000494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757000495 inhibitor-cofactor binding pocket; inhibition site 164757000496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757000497 catalytic residue [active] 164757000498 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757000499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757000500 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757000501 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000502 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757000503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000505 active site 164757000506 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 164757000507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757000508 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757000509 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757000510 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757000511 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757000512 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757000513 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757000514 substrate binding pocket [chemical binding]; other site 164757000515 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757000516 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757000517 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757000518 putative acyl-acceptor binding pocket; other site 164757000519 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 164757000520 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 164757000521 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 164757000522 CsbD-like; Region: CsbD; pfam05532 164757000523 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 164757000524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000526 active site 164757000527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000529 active site 164757000530 Helix-turn-helix domain; Region: HTH_18; pfam12833 164757000531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757000532 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 164757000533 RibD C-terminal domain; Region: RibD_C; cl17279 164757000534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000536 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 164757000537 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757000538 NAD binding site [chemical binding]; other site 164757000539 catalytic residues [active] 164757000540 Methyltransferase domain; Region: Methyltransf_11; pfam08241 164757000541 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757000542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757000543 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 164757000544 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757000545 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 164757000546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757000547 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757000548 putative AMP binding site [chemical binding]; other site 164757000549 putative active site [active] 164757000550 acyl-activating enzyme (AAE) consensus motif; other site 164757000551 putative CoA binding site [chemical binding]; other site 164757000552 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 164757000553 active site 164757000554 substrate binding pocket [chemical binding]; other site 164757000555 homodimer interaction site [polypeptide binding]; other site 164757000556 Transmembrane secretion effector; Region: MFS_3; pfam05977 164757000557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757000558 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 164757000559 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 164757000560 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 164757000561 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757000562 Ligand Binding Site [chemical binding]; other site 164757000563 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 164757000564 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 164757000565 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 164757000566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757000567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757000568 catalytic residue [active] 164757000569 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 164757000570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757000571 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757000572 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 164757000573 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757000574 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 164757000575 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 164757000576 putative dimer interface [polypeptide binding]; other site 164757000577 putative active site [active] 164757000578 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 164757000579 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 164757000580 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 164757000581 putative active site [active] 164757000582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000584 O-methyltransferase; Region: Methyltransf_2; pfam00891 164757000585 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757000586 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757000587 active site 2 [active] 164757000588 active site 1 [active] 164757000589 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 164757000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000591 NAD(P) binding site [chemical binding]; other site 164757000592 active site 164757000593 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 164757000594 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757000595 dimer interface [polypeptide binding]; other site 164757000596 active site 164757000597 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 164757000598 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 164757000599 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 164757000600 FAD binding site [chemical binding]; other site 164757000601 substrate binding site [chemical binding]; other site 164757000602 catalytic residues [active] 164757000603 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 164757000604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757000605 active site 164757000606 ATP binding site [chemical binding]; other site 164757000607 substrate binding site [chemical binding]; other site 164757000608 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 164757000609 activation loop (A-loop); other site 164757000610 cyclase homology domain; Region: CHD; cd07302 164757000611 nucleotidyl binding site; other site 164757000612 metal binding site [ion binding]; metal-binding site 164757000613 dimer interface [polypeptide binding]; other site 164757000614 AAA ATPase domain; Region: AAA_16; pfam13191 164757000615 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757000616 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757000617 active site 164757000618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757000619 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757000620 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 164757000621 KR domain; Region: KR; pfam08659 164757000622 NADP binding site [chemical binding]; other site 164757000623 active site 164757000624 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757000625 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 164757000626 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757000627 active site 164757000628 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757000629 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 164757000630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000631 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 164757000632 Enoylreductase; Region: PKS_ER; smart00829 164757000633 NAD(P) binding site [chemical binding]; other site 164757000634 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 164757000635 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 164757000636 putative NADP binding site [chemical binding]; other site 164757000637 active site 164757000638 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757000639 Transport protein; Region: actII; TIGR00833 164757000640 acyl-CoA synthetase; Validated; Region: PRK05850 164757000641 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757000642 acyl-activating enzyme (AAE) consensus motif; other site 164757000643 active site 164757000644 PE-PPE domain; Region: PE-PPE; pfam08237 164757000645 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 164757000646 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 164757000647 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 164757000648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757000649 catalytic loop [active] 164757000650 iron binding site [ion binding]; other site 164757000651 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 164757000652 L-aspartate oxidase; Provisional; Region: PRK06175 164757000653 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757000654 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 164757000655 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 164757000656 tetramer interface [polypeptide binding]; other site 164757000657 active site 164757000658 Mg2+/Mn2+ binding site [ion binding]; other site 164757000659 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 164757000660 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 164757000661 putative dimer interface [polypeptide binding]; other site 164757000662 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 164757000663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757000664 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 164757000665 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757000666 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 164757000667 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 164757000668 GAF domain; Region: GAF; cl17456 164757000669 GAF domain; Region: GAF_2; pfam13185 164757000670 ANTAR domain; Region: ANTAR; pfam03861 164757000671 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 164757000672 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 164757000673 putative active site [active] 164757000674 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 164757000675 putative active site [active] 164757000676 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 164757000677 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 164757000678 active site 164757000679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 164757000680 DNA binding site [nucleotide binding] 164757000681 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 164757000682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757000683 Coenzyme A binding pocket [chemical binding]; other site 164757000684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757000685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757000686 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 164757000687 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 164757000688 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 164757000689 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 164757000690 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 164757000691 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 164757000692 intersubunit interface [polypeptide binding]; other site 164757000693 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 164757000694 short chain dehydrogenase; Provisional; Region: PRK08267 164757000695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000696 NAD(P) binding site [chemical binding]; other site 164757000697 active site 164757000698 Lysine efflux permease [General function prediction only]; Region: COG1279 164757000699 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757000700 Permease; Region: Permease; pfam02405 164757000701 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757000702 Permease; Region: Permease; pfam02405 164757000703 mce related protein; Region: MCE; pfam02470 164757000704 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757000705 mce related protein; Region: MCE; pfam02470 164757000706 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000707 mce related protein; Region: MCE; pfam02470 164757000708 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757000709 mce related protein; Region: MCE; pfam02470 164757000710 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000711 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000712 mce related protein; Region: MCE; pfam02470 164757000713 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757000714 mce related protein; Region: MCE; pfam02470 164757000715 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757000716 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757000717 CoenzymeA binding site [chemical binding]; other site 164757000718 subunit interaction site [polypeptide binding]; other site 164757000719 PHB binding site; other site 164757000720 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 164757000721 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757000722 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757000723 Transcriptional regulator PadR-like family; Region: PadR; cl17335 164757000724 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 164757000725 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 164757000726 active site 164757000727 FMN binding site [chemical binding]; other site 164757000728 substrate binding site [chemical binding]; other site 164757000729 putative catalytic residue [active] 164757000730 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757000731 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757000732 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757000733 classical (c) SDRs; Region: SDR_c; cd05233 164757000734 NAD(P) binding site [chemical binding]; other site 164757000735 active site 164757000736 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 164757000737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757000738 short chain dehydrogenase; Provisional; Region: PRK12828 164757000739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000740 NAD(P) binding site [chemical binding]; other site 164757000741 active site 164757000742 SnoaL-like domain; Region: SnoaL_4; pfam13577 164757000743 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757000744 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 164757000745 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757000746 hydrophobic ligand binding site; other site 164757000747 short chain dehydrogenase; Provisional; Region: PRK12828 164757000748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000749 NAD(P) binding site [chemical binding]; other site 164757000750 active site 164757000751 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757000752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757000753 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757000754 hypothetical protein; Validated; Region: PRK07121 164757000755 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757000756 classical (c) SDRs; Region: SDR_c; cd05233 164757000757 short chain dehydrogenase; Provisional; Region: PRK08267 164757000758 NAD(P) binding site [chemical binding]; other site 164757000759 active site 164757000760 classical (c) SDRs; Region: SDR_c; cd05233 164757000761 NAD(P) binding site [chemical binding]; other site 164757000762 active site 164757000763 enoyl-CoA hydratase; Provisional; Region: PRK09245 164757000764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757000765 substrate binding site [chemical binding]; other site 164757000766 oxyanion hole (OAH) forming residues; other site 164757000767 trimer interface [polypeptide binding]; other site 164757000768 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 164757000769 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757000770 NAD binding site [chemical binding]; other site 164757000771 catalytic residues [active] 164757000772 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 164757000773 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757000774 catalytic Zn binding site [ion binding]; other site 164757000775 structural Zn binding site [ion binding]; other site 164757000776 tetramer interface [polypeptide binding]; other site 164757000777 acyl-CoA synthetase; Validated; Region: PRK08316 164757000778 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757000779 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757000780 acyl-activating enzyme (AAE) consensus motif; other site 164757000781 putative AMP binding site [chemical binding]; other site 164757000782 putative active site [active] 164757000783 putative CoA binding site [chemical binding]; other site 164757000784 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757000785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757000786 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 164757000787 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 164757000788 NAD(P) binding site [chemical binding]; other site 164757000789 homodimer interface [polypeptide binding]; other site 164757000790 active site 164757000791 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 164757000792 putative allyl alcohol dehydrogenase; Provisional; Region: PLN03154 164757000793 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757000794 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757000795 substrate binding pocket [chemical binding]; other site 164757000796 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757000797 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757000798 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 164757000799 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757000800 hypothetical protein; Validated; Region: PRK07121 164757000801 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757000802 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 164757000803 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 164757000804 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 164757000805 active site 164757000806 Fe binding site [ion binding]; other site 164757000807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000809 active site 164757000810 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 164757000811 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 164757000812 FAD binding pocket [chemical binding]; other site 164757000813 FAD binding motif [chemical binding]; other site 164757000814 phosphate binding motif [ion binding]; other site 164757000815 beta-alpha-beta structure motif; other site 164757000816 NAD(p) ribose binding residues [chemical binding]; other site 164757000817 NAD binding pocket [chemical binding]; other site 164757000818 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 164757000819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757000820 catalytic loop [active] 164757000821 iron binding site [ion binding]; other site 164757000822 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757000823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757000824 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 164757000825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000827 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757000828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757000829 putative substrate translocation pore; other site 164757000830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757000831 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 164757000832 NAD(P) binding site [chemical binding]; other site 164757000833 active site 164757000834 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757000835 Ligand Binding Site [chemical binding]; other site 164757000836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757000837 Ligand Binding Site [chemical binding]; other site 164757000838 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757000839 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757000840 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757000841 classical (c) SDRs; Region: SDR_c; cd05233 164757000842 NAD(P) binding site [chemical binding]; other site 164757000843 active site 164757000844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000846 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757000847 Cytochrome P450; Region: p450; cl12078 164757000848 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 164757000849 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 164757000850 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757000851 classical (c) SDRs; Region: SDR_c; cd05233 164757000852 NAD(P) binding site [chemical binding]; other site 164757000853 active site 164757000854 short chain dehydrogenase; Provisional; Region: PRK12827 164757000855 classical (c) SDRs; Region: SDR_c; cd05233 164757000856 NAD(P) binding site [chemical binding]; other site 164757000857 active site 164757000858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000860 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 164757000861 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757000862 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757000863 active site 164757000864 Transcriptional regulators [Transcription]; Region: GntR; COG1802 164757000865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757000866 DNA-binding site [nucleotide binding]; DNA binding site 164757000867 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 164757000868 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 164757000869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 164757000870 putative substrate translocation pore; other site 164757000871 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 164757000872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757000873 substrate binding site [chemical binding]; other site 164757000874 oxyanion hole (OAH) forming residues; other site 164757000875 trimer interface [polypeptide binding]; other site 164757000876 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 164757000877 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 164757000878 active site 164757000879 hypothetical protein; Provisional; Region: PRK06062 164757000880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757000881 inhibitor-cofactor binding pocket; inhibition site 164757000882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757000883 catalytic residue [active] 164757000884 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 164757000885 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 164757000886 tetrameric interface [polypeptide binding]; other site 164757000887 NAD binding site [chemical binding]; other site 164757000888 catalytic residues [active] 164757000889 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 164757000890 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757000891 PAS domain; Region: PAS_9; pfam13426 164757000892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757000893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757000894 dimer interface [polypeptide binding]; other site 164757000895 phosphorylation site [posttranslational modification] 164757000896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757000897 ATP binding site [chemical binding]; other site 164757000898 Mg2+ binding site [ion binding]; other site 164757000899 G-X-G motif; other site 164757000900 Response regulator receiver domain; Region: Response_reg; pfam00072 164757000901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757000902 active site 164757000903 phosphorylation site [posttranslational modification] 164757000904 intermolecular recognition site; other site 164757000905 dimerization interface [polypeptide binding]; other site 164757000906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 164757000907 PAS domain; Region: PAS_9; pfam13426 164757000908 putative active site [active] 164757000909 heme pocket [chemical binding]; other site 164757000910 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757000911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 164757000912 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 164757000913 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757000914 anti sigma factor interaction site; other site 164757000915 regulatory phosphorylation site [posttranslational modification]; other site 164757000916 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 164757000917 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 164757000918 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 164757000919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757000920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 164757000921 dimerization interface [polypeptide binding]; other site 164757000922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757000923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757000924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757000925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757000926 metal binding site [ion binding]; metal-binding site 164757000927 active site 164757000928 I-site; other site 164757000929 Putative transcription activator [Transcription]; Region: TenA; COG0819 164757000930 Methyltransferase domain; Region: Methyltransf_24; pfam13578 164757000931 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757000932 anti sigma factor interaction site; other site 164757000933 regulatory phosphorylation site [posttranslational modification]; other site 164757000934 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 164757000935 nucleotide binding site [chemical binding]; other site 164757000936 acyl-CoA synthetase; Validated; Region: PRK07788 164757000937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757000938 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757000939 acyl-activating enzyme (AAE) consensus motif; other site 164757000940 acyl-activating enzyme (AAE) consensus motif; other site 164757000941 putative AMP binding site [chemical binding]; other site 164757000942 putative active site [active] 164757000943 putative CoA binding site [chemical binding]; other site 164757000944 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 164757000945 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 164757000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757000947 putative substrate translocation pore; other site 164757000948 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 164757000949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757000951 active site 164757000952 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757000953 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 164757000954 FAD binding site [chemical binding]; other site 164757000955 substrate binding site [chemical binding]; other site 164757000956 catalytic base [active] 164757000957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757000958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757000959 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 164757000960 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757000961 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 164757000962 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 164757000963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757000964 Walker A motif; other site 164757000965 ATP binding site [chemical binding]; other site 164757000966 Walker B motif; other site 164757000967 arginine finger; other site 164757000968 Protein of unknown function (DUF690); Region: DUF690; cl04939 164757000969 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 164757000970 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757000971 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 164757000972 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757000973 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757000974 PE family; Region: PE; pfam00934 164757000975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 164757000976 PPE family; Region: PPE; pfam00823 164757000977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 164757000978 EspG family; Region: ESX-1_EspG; pfam14011 164757000979 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 164757000980 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 164757000981 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 164757000982 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 164757000983 active site 164757000984 catalytic residues [active] 164757000985 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 164757000986 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 164757000987 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 164757000988 NAD(P) binding site [chemical binding]; other site 164757000989 LDH/MDH dimer interface [polypeptide binding]; other site 164757000990 substrate binding site [chemical binding]; other site 164757000991 pyruvate kinase; Provisional; Region: PRK14725 164757000992 active site 164757000993 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 164757000994 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757000995 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 164757000996 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 164757000997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757000998 S-adenosylmethionine binding site [chemical binding]; other site 164757000999 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 164757001000 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 164757001001 CysD dimerization site [polypeptide binding]; other site 164757001002 G1 box; other site 164757001003 putative GEF interaction site [polypeptide binding]; other site 164757001004 GTP/Mg2+ binding site [chemical binding]; other site 164757001005 Switch I region; other site 164757001006 G2 box; other site 164757001007 G3 box; other site 164757001008 Switch II region; other site 164757001009 G4 box; other site 164757001010 G5 box; other site 164757001011 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 164757001012 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 164757001013 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 164757001014 ligand-binding site [chemical binding]; other site 164757001015 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 164757001016 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 164757001017 Active Sites [active] 164757001018 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 164757001019 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 164757001020 Sulfatase; Region: Sulfatase; pfam00884 164757001021 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757001022 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 164757001023 active site 164757001024 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 164757001025 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 164757001026 active site 164757001027 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 164757001028 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 164757001029 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757001030 putative DNA binding site [nucleotide binding]; other site 164757001031 putative Zn2+ binding site [ion binding]; other site 164757001032 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 164757001033 putative hydrophobic ligand binding site [chemical binding]; other site 164757001034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 164757001035 SnoaL-like domain; Region: SnoaL_3; pfam13474 164757001036 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757001037 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757001038 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757001039 iron-sulfur cluster [ion binding]; other site 164757001040 [2Fe-2S] cluster binding site [ion binding]; other site 164757001041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757001042 nucleotide binding site [chemical binding]; other site 164757001043 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 164757001044 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 164757001045 putative di-iron ligands [ion binding]; other site 164757001046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757001047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757001048 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757001049 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 164757001050 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757001051 GAF domain; Region: GAF; pfam01590 164757001052 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 164757001053 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757001054 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 164757001055 DXD motif; other site 164757001056 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757001057 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 164757001058 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757001059 anti sigma factor interaction site; other site 164757001060 regulatory phosphorylation site [posttranslational modification]; other site 164757001061 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 164757001062 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 164757001063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001065 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 164757001066 PE-PPE domain; Region: PE-PPE; pfam08237 164757001067 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 164757001068 active site 164757001069 catalytic residues [active] 164757001070 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 164757001071 PE-PPE domain; Region: PE-PPE; pfam08237 164757001072 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 164757001073 heme-binding site [chemical binding]; other site 164757001074 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757001075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001076 NAD(P) binding site [chemical binding]; other site 164757001077 active site 164757001078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001079 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757001080 NAD(P) binding site [chemical binding]; other site 164757001081 active site 164757001082 Secretory lipase; Region: LIP; pfam03583 164757001083 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 164757001084 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757001085 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757001086 active site 164757001087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757001088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757001089 dimerization interface [polypeptide binding]; other site 164757001090 DNA binding residues [nucleotide binding] 164757001091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757001092 S-adenosylmethionine binding site [chemical binding]; other site 164757001093 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 164757001094 trimer interface [polypeptide binding]; other site 164757001095 active site 164757001096 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 164757001097 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757001098 Cytochrome P450; Region: p450; cl12078 164757001099 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757001100 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757001101 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757001102 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 164757001103 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 164757001104 substrate binding site; other site 164757001105 tetramer interface; other site 164757001106 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 164757001107 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 164757001108 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 164757001109 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 164757001110 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 164757001111 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 164757001112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757001113 catalytic loop [active] 164757001114 iron binding site [ion binding]; other site 164757001115 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 164757001116 YibE/F-like protein; Region: YibE_F; pfam07907 164757001117 aminotransferase AlaT; Validated; Region: PRK09265 164757001118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757001119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757001120 homodimer interface [polypeptide binding]; other site 164757001121 catalytic residue [active] 164757001122 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 164757001123 4Fe-4S binding domain; Region: Fer4; cl02805 164757001124 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 164757001125 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 164757001126 4Fe-4S binding domain; Region: Fer4; pfam00037 164757001127 Cysteine-rich domain; Region: CCG; pfam02754 164757001128 Cysteine-rich domain; Region: CCG; pfam02754 164757001129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757001130 dimerization interface [polypeptide binding]; other site 164757001131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757001132 DNA binding residues [nucleotide binding] 164757001133 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757001134 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 164757001135 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 164757001136 G1 box; other site 164757001137 GTP/Mg2+ binding site [chemical binding]; other site 164757001138 G2 box; other site 164757001139 Switch I region; other site 164757001140 G3 box; other site 164757001141 Switch II region; other site 164757001142 G4 box; other site 164757001143 G5 box; other site 164757001144 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 164757001145 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 164757001146 G1 box; other site 164757001147 GTP/Mg2+ binding site [chemical binding]; other site 164757001148 G2 box; other site 164757001149 Switch I region; other site 164757001150 G3 box; other site 164757001151 Switch II region; other site 164757001152 G4 box; other site 164757001153 G5 box; other site 164757001154 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757001155 nucleotide binding site [chemical binding]; other site 164757001156 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757001157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757001158 TIGR03085 family protein; Region: TIGR03085 164757001159 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 164757001160 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 164757001161 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757001162 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757001163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757001164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757001165 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757001166 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 164757001167 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 164757001168 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 164757001169 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 164757001170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757001171 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 164757001172 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 164757001173 nucleotide binding site [chemical binding]; other site 164757001174 NEF interaction site [polypeptide binding]; other site 164757001175 SBD interface [polypeptide binding]; other site 164757001176 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 164757001177 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 164757001178 dimer interface [polypeptide binding]; other site 164757001179 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 164757001180 chaperone protein DnaJ; Provisional; Region: PRK14279 164757001181 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 164757001182 HSP70 interaction site [polypeptide binding]; other site 164757001183 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 164757001184 Zn binding sites [ion binding]; other site 164757001185 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 164757001186 dimer interface [polypeptide binding]; other site 164757001187 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 164757001188 DNA binding residues [nucleotide binding] 164757001189 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757001190 putative dimer interface [polypeptide binding]; other site 164757001191 mannosyltransferase; Provisional; Region: pimE; PRK13375 164757001192 mannosyltransferase; Provisional; Region: pimE; PRK13375 164757001193 mannosyltransferase; Provisional; Region: pimE; PRK13375 164757001194 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 164757001195 active site 164757001196 catalytic residues [active] 164757001197 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 164757001198 heme-binding site [chemical binding]; other site 164757001199 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 164757001200 FMN reductase; Validated; Region: fre; PRK08051 164757001201 FAD binding pocket [chemical binding]; other site 164757001202 FAD binding motif [chemical binding]; other site 164757001203 phosphate binding motif [ion binding]; other site 164757001204 beta-alpha-beta structure motif; other site 164757001205 NAD binding pocket [chemical binding]; other site 164757001206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001208 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 164757001209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 164757001210 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 164757001211 putative active site [active] 164757001212 putative metal binding residues [ion binding]; other site 164757001213 signature motif; other site 164757001214 putative dimer interface [polypeptide binding]; other site 164757001215 putative phosphate binding site [ion binding]; other site 164757001216 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 164757001217 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 164757001218 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 164757001219 Clp amino terminal domain; Region: Clp_N; pfam02861 164757001220 Clp amino terminal domain; Region: Clp_N; pfam02861 164757001221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757001222 Walker A motif; other site 164757001223 ATP binding site [chemical binding]; other site 164757001224 Walker B motif; other site 164757001225 arginine finger; other site 164757001226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757001227 Walker A motif; other site 164757001228 ATP binding site [chemical binding]; other site 164757001229 Walker B motif; other site 164757001230 arginine finger; other site 164757001231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 164757001232 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757001233 classical (c) SDRs; Region: SDR_c; cd05233 164757001234 NAD(P) binding site [chemical binding]; other site 164757001235 active site 164757001236 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 164757001237 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 164757001238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757001239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757001240 putative substrate translocation pore; other site 164757001241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757001242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001244 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 164757001245 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 164757001246 Thioredoxin; Region: Thioredoxin_4; pfam13462 164757001247 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 164757001248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757001249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757001250 LysR substrate binding domain; Region: LysR_substrate; pfam03466 164757001251 dimerization interface [polypeptide binding]; other site 164757001252 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 164757001253 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 164757001254 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 164757001255 XdhC Rossmann domain; Region: XdhC_C; pfam13478 164757001256 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 164757001257 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 164757001258 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 164757001259 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 164757001260 catalytic loop [active] 164757001261 iron binding site [ion binding]; other site 164757001262 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 164757001263 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 164757001264 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 164757001265 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 164757001266 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 164757001267 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 164757001268 XdhC Rossmann domain; Region: XdhC_C; pfam13478 164757001269 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757001270 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 164757001271 putative hydrophobic ligand binding site [chemical binding]; other site 164757001272 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 164757001273 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 164757001274 metal ion-dependent adhesion site (MIDAS); other site 164757001275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757001276 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 164757001277 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757001278 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 164757001279 short chain dehydrogenase; Validated; Region: PRK08264 164757001280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001281 NAD(P) binding site [chemical binding]; other site 164757001282 active site 164757001283 Nitronate monooxygenase; Region: NMO; pfam03060 164757001284 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757001285 FMN binding site [chemical binding]; other site 164757001286 substrate binding site [chemical binding]; other site 164757001287 putative catalytic residue [active] 164757001288 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 164757001289 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 164757001290 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 164757001291 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757001292 NAD(P) binding site [chemical binding]; other site 164757001293 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 164757001294 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 164757001295 active site 164757001296 intersubunit interface [polypeptide binding]; other site 164757001297 zinc binding site [ion binding]; other site 164757001298 Na+ binding site [ion binding]; other site 164757001299 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 164757001300 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 164757001301 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 164757001302 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 164757001303 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 164757001304 Peptidase family M50; Region: Peptidase_M50; pfam02163 164757001305 active site 164757001306 putative substrate binding region [chemical binding]; other site 164757001307 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757001308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757001309 DNA-binding site [nucleotide binding]; DNA binding site 164757001310 FCD domain; Region: FCD; pfam07729 164757001311 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 164757001312 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 164757001313 catalytic triad [active] 164757001314 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 164757001315 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 164757001316 active site 164757001317 metal binding site [ion binding]; metal-binding site 164757001318 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757001319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757001320 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 164757001321 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 164757001322 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757001323 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757001324 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 164757001325 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 164757001326 GDP-binding site [chemical binding]; other site 164757001327 ACT binding site; other site 164757001328 IMP binding site; other site 164757001329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757001330 CoenzymeA binding site [chemical binding]; other site 164757001331 subunit interaction site [polypeptide binding]; other site 164757001332 PHB binding site; other site 164757001333 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757001334 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757001335 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757001336 Cytochrome P450; Region: p450; cl12078 164757001337 MMPL family; Region: MMPL; pfam03176 164757001338 MMPL family; Region: MMPL; pfam03176 164757001339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757001340 MarR family; Region: MarR_2; pfam12802 164757001341 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 164757001342 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 164757001343 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 164757001344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757001345 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757001346 active site residue [active] 164757001347 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 164757001348 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 164757001349 homodimer interface [polypeptide binding]; other site 164757001350 substrate-cofactor binding pocket; other site 164757001351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757001352 catalytic residue [active] 164757001353 short chain dehydrogenase; Provisional; Region: PRK07825 164757001354 classical (c) SDRs; Region: SDR_c; cd05233 164757001355 NAD(P) binding site [chemical binding]; other site 164757001356 active site 164757001357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757001358 Coenzyme A binding pocket [chemical binding]; other site 164757001359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757001360 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 164757001361 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 164757001362 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757001363 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 164757001364 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 164757001365 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 164757001366 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 164757001367 DXD motif; other site 164757001368 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 164757001369 phosphate acetyltransferase; Reviewed; Region: PRK05632 164757001370 DRTGG domain; Region: DRTGG; pfam07085 164757001371 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 164757001372 propionate/acetate kinase; Provisional; Region: PRK12379 164757001373 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 164757001374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757001375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757001376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757001377 active site 164757001378 ATP binding site [chemical binding]; other site 164757001379 substrate binding site [chemical binding]; other site 164757001380 activation loop (A-loop); other site 164757001381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757001382 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757001383 substrate binding pocket [chemical binding]; other site 164757001384 membrane-bound complex binding site; other site 164757001385 hinge residues; other site 164757001386 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 164757001387 nudix motif; other site 164757001388 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 164757001389 thiamine phosphate binding site [chemical binding]; other site 164757001390 active site 164757001391 pyrophosphate binding site [ion binding]; other site 164757001392 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 164757001393 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 164757001394 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 164757001395 thiS-thiF/thiG interaction site; other site 164757001396 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 164757001397 ThiS interaction site; other site 164757001398 putative active site [active] 164757001399 tetramer interface [polypeptide binding]; other site 164757001400 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 164757001401 active site 164757001402 catalytic triad [active] 164757001403 oxyanion hole [active] 164757001404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 164757001405 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 164757001406 Walker A/P-loop; other site 164757001407 ATP binding site [chemical binding]; other site 164757001408 Q-loop/lid; other site 164757001409 ABC transporter signature motif; other site 164757001410 Walker B; other site 164757001411 D-loop; other site 164757001412 H-loop/switch region; other site 164757001413 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 164757001414 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 164757001415 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 164757001416 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 164757001417 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 164757001418 PA/protease or protease-like domain interface [polypeptide binding]; other site 164757001419 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 164757001420 active site 164757001421 metal binding site [ion binding]; metal-binding site 164757001422 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 164757001423 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 164757001424 PA/protease or protease-like domain interface [polypeptide binding]; other site 164757001425 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 164757001426 Peptidase family M28; Region: Peptidase_M28; pfam04389 164757001427 active site 164757001428 metal binding site [ion binding]; metal-binding site 164757001429 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 164757001430 amino acid transporter; Region: 2A0306; TIGR00909 164757001431 amino acid transporter; Region: 2A0306; TIGR00909 164757001432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001436 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757001437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757001438 Septum formation; Region: Septum_form; pfam13845 164757001439 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 164757001440 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 164757001441 dimer interface [polypeptide binding]; other site 164757001442 substrate binding site [chemical binding]; other site 164757001443 ATP binding site [chemical binding]; other site 164757001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757001445 putative substrate translocation pore; other site 164757001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757001447 AAA ATPase domain; Region: AAA_16; pfam13191 164757001448 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 164757001449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757001450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757001451 DNA binding residues [nucleotide binding] 164757001452 dimerization interface [polypeptide binding]; other site 164757001453 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 164757001454 putative catalytic site [active] 164757001455 putative phosphate binding site [ion binding]; other site 164757001456 active site 164757001457 metal binding site A [ion binding]; metal-binding site 164757001458 DNA binding site [nucleotide binding] 164757001459 putative AP binding site [nucleotide binding]; other site 164757001460 putative metal binding site B [ion binding]; other site 164757001461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 164757001462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757001463 Coenzyme A binding pocket [chemical binding]; other site 164757001464 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 164757001465 active site 164757001466 catalytic residues [active] 164757001467 metal binding site [ion binding]; metal-binding site 164757001468 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 164757001469 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 164757001470 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 164757001471 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 164757001472 E-class dimer interface [polypeptide binding]; other site 164757001473 P-class dimer interface [polypeptide binding]; other site 164757001474 active site 164757001475 Cu2+ binding site [ion binding]; other site 164757001476 Zn2+ binding site [ion binding]; other site 164757001477 carboxylate-amine ligase; Provisional; Region: PRK13517 164757001478 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 164757001479 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 164757001480 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 164757001481 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757001482 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757001483 Leucine carboxyl methyltransferase; Region: LCM; cl01306 164757001484 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 164757001485 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 164757001486 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 164757001487 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 164757001488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757001489 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 164757001490 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 164757001491 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 164757001492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757001493 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 164757001494 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 164757001495 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 164757001496 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 164757001497 transmembrane helices; other site 164757001498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 164757001499 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 164757001500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 164757001501 Histidine kinase; Region: HisKA_3; pfam07730 164757001502 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 164757001503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757001504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757001505 active site 164757001506 phosphorylation site [posttranslational modification] 164757001507 intermolecular recognition site; other site 164757001508 dimerization interface [polypeptide binding]; other site 164757001509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757001510 DNA binding residues [nucleotide binding] 164757001511 dimerization interface [polypeptide binding]; other site 164757001512 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 164757001513 2TM domain; Region: 2TM; pfam13239 164757001514 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 164757001515 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 164757001516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757001517 Walker A motif; other site 164757001518 ATP binding site [chemical binding]; other site 164757001519 Walker B motif; other site 164757001520 arginine finger; other site 164757001521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757001522 Walker A motif; other site 164757001523 ATP binding site [chemical binding]; other site 164757001524 Walker B motif; other site 164757001525 arginine finger; other site 164757001526 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 164757001527 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 164757001528 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 164757001529 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 164757001530 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 164757001531 dimer interface [polypeptide binding]; other site 164757001532 putative functional site; other site 164757001533 putative MPT binding site; other site 164757001534 short chain dehydrogenase; Provisional; Region: PRK06197 164757001535 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 164757001536 putative NAD(P) binding site [chemical binding]; other site 164757001537 active site 164757001538 Uncharacterized conserved protein [Function unknown]; Region: COG3402 164757001539 Predicted membrane protein [Function unknown]; Region: COG3428 164757001540 Bacterial PH domain; Region: DUF304; pfam03703 164757001541 Bacterial PH domain; Region: DUF304; cl01348 164757001542 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 164757001543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757001544 active site 164757001545 motif I; other site 164757001546 motif II; other site 164757001547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757001548 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 164757001549 TrkA-N domain; Region: TrkA_N; pfam02254 164757001550 PAS domain; Region: PAS_9; pfam13426 164757001551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757001552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757001553 DNA binding residues [nucleotide binding] 164757001554 dimerization interface [polypeptide binding]; other site 164757001555 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 164757001556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757001557 ATP binding site [chemical binding]; other site 164757001558 putative Mg++ binding site [ion binding]; other site 164757001559 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 164757001560 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 164757001561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 164757001562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757001563 ABC transporter signature motif; other site 164757001564 Walker B; other site 164757001565 D-loop; other site 164757001566 H-loop/switch region; other site 164757001567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757001568 Walker A/P-loop; other site 164757001569 ATP binding site [chemical binding]; other site 164757001570 Q-loop/lid; other site 164757001571 ABC transporter signature motif; other site 164757001572 Walker B; other site 164757001573 D-loop; other site 164757001574 H-loop/switch region; other site 164757001575 Cupin domain; Region: Cupin_2; pfam07883 164757001576 short chain dehydrogenase; Provisional; Region: PRK06197 164757001577 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 164757001578 putative NAD(P) binding site [chemical binding]; other site 164757001579 active site 164757001580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001582 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 164757001583 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 164757001584 ring oligomerisation interface [polypeptide binding]; other site 164757001585 ATP/Mg binding site [chemical binding]; other site 164757001586 stacking interactions; other site 164757001587 hinge regions; other site 164757001588 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 164757001589 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757001590 active site 164757001591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757001592 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 164757001593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757001594 Protein of unknown function (DUF664); Region: DUF664; pfam04978 164757001595 DinB superfamily; Region: DinB_2; pfam12867 164757001596 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757001597 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 164757001598 NAD(P) binding site [chemical binding]; other site 164757001599 catalytic residues [active] 164757001600 enoyl-CoA hydratase; Provisional; Region: PRK12478 164757001601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757001602 substrate binding site [chemical binding]; other site 164757001603 oxyanion hole (OAH) forming residues; other site 164757001604 trimer interface [polypeptide binding]; other site 164757001605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757001606 Cytochrome P450; Region: p450; cl12078 164757001607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757001608 classical (c) SDRs; Region: SDR_c; cd05233 164757001609 NAD(P) binding site [chemical binding]; other site 164757001610 active site 164757001611 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 164757001612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757001613 Cytochrome P450; Region: p450; cl12078 164757001614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001615 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757001616 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757001617 active site 164757001618 Homeodomain-like domain; Region: HTH_23; pfam13384 164757001619 Helix-turn-helix domain; Region: HTH_38; pfam13936 164757001620 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 164757001621 Integrase core domain; Region: rve; pfam00665 164757001622 Winged helix-turn helix; Region: HTH_29; pfam13551 164757001623 Integrase core domain; Region: rve; pfam00665 164757001624 Integrase core domain; Region: rve_3; pfam13683 164757001625 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 164757001626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757001627 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757001628 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757001629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001630 acetoin reductases; Region: 23BDH; TIGR02415 164757001631 NAD(P) binding site [chemical binding]; other site 164757001632 active site 164757001633 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 164757001634 GAF domain; Region: GAF; pfam01590 164757001635 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 164757001636 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757001637 NAD(P) binding site [chemical binding]; other site 164757001638 catalytic residues [active] 164757001639 Protein of unknown function (DUF779); Region: DUF779; pfam05610 164757001640 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 164757001641 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 164757001642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757001643 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 164757001644 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757001645 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757001646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757001648 non-specific DNA binding site [nucleotide binding]; other site 164757001649 salt bridge; other site 164757001650 sequence-specific DNA binding site [nucleotide binding]; other site 164757001651 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 164757001652 Domain of unknown function (DUF955); Region: DUF955; pfam06114 164757001653 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 164757001654 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 164757001655 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757001656 active site 2 [active] 164757001657 active site 1 [active] 164757001658 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757001659 isocitrate lyase; Provisional; Region: PRK15063 164757001660 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 164757001661 tetramer interface [polypeptide binding]; other site 164757001662 active site 164757001663 Mg2+/Mn2+ binding site [ion binding]; other site 164757001664 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 164757001665 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 164757001666 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 164757001667 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 164757001668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001670 Predicted membrane protein [Function unknown]; Region: COG2733 164757001671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757001672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757001673 non-specific DNA binding site [nucleotide binding]; other site 164757001674 salt bridge; other site 164757001675 sequence-specific DNA binding site [nucleotide binding]; other site 164757001676 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 164757001677 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 164757001678 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 164757001679 catalytic residue [active] 164757001680 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 164757001681 Predicted amidohydrolase [General function prediction only]; Region: COG0388 164757001682 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 164757001683 putative active site [active] 164757001684 catalytic triad [active] 164757001685 putative dimer interface [polypeptide binding]; other site 164757001686 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 164757001687 Na binding site [ion binding]; other site 164757001688 putative glycosylation site [posttranslational modification]; other site 164757001689 putative glycosylation site [posttranslational modification]; other site 164757001690 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 164757001691 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 164757001692 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 164757001693 FAD binding domain; Region: FAD_binding_4; pfam01565 164757001694 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 164757001695 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 164757001696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757001697 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 164757001698 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757001699 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 164757001700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001701 NAD(P) binding site [chemical binding]; other site 164757001702 active site 164757001703 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 164757001704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757001705 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 164757001706 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 164757001707 putative ADP-binding pocket [chemical binding]; other site 164757001708 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 164757001709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757001710 catalytic core [active] 164757001711 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 164757001712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757001713 dimer interface [polypeptide binding]; other site 164757001714 phosphorylation site [posttranslational modification] 164757001715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757001716 ATP binding site [chemical binding]; other site 164757001717 G-X-G motif; other site 164757001718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757001719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757001720 active site 164757001721 phosphorylation site [posttranslational modification] 164757001722 intermolecular recognition site; other site 164757001723 dimerization interface [polypeptide binding]; other site 164757001724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757001725 DNA binding site [nucleotide binding] 164757001726 YCII-related domain; Region: YCII; cl00999 164757001727 exopolyphosphatase; Region: exo_poly_only; TIGR03706 164757001728 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 164757001729 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 164757001730 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 164757001731 DNA interaction; other site 164757001732 Metal-binding active site; metal-binding site 164757001733 AP (apurinic/apyrimidinic) site pocket; other site 164757001734 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757001735 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 164757001736 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 164757001737 DNA binding domain, excisionase family; Region: excise; TIGR01764 164757001738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757001739 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 164757001740 putative NAD(P) binding site [chemical binding]; other site 164757001741 active site 164757001742 putative substrate binding site [chemical binding]; other site 164757001743 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757001744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757001745 putative acyl-acceptor binding pocket; other site 164757001746 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757001747 active site 164757001748 catalytic site [active] 164757001749 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 164757001750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757001751 motif II; other site 164757001752 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 164757001753 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 164757001754 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 164757001755 tRNA; other site 164757001756 putative tRNA binding site [nucleotide binding]; other site 164757001757 putative NADP binding site [chemical binding]; other site 164757001758 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 164757001759 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 164757001760 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 164757001761 domain interfaces; other site 164757001762 active site 164757001763 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 164757001764 homodimer interface [polypeptide binding]; other site 164757001765 active site 164757001766 SAM binding site [chemical binding]; other site 164757001767 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 164757001768 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 164757001769 active site 164757001770 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 164757001771 dimer interface [polypeptide binding]; other site 164757001772 active site 164757001773 Schiff base residues; other site 164757001774 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757001775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001777 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757001778 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757001779 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 164757001780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757001781 inhibitor-cofactor binding pocket; inhibition site 164757001782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757001783 catalytic residue [active] 164757001784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757001785 catalytic core [active] 164757001786 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 164757001787 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757001788 catalytic residues [active] 164757001789 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 164757001790 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 164757001791 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 164757001792 ResB-like family; Region: ResB; pfam05140 164757001793 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 164757001794 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 164757001795 AAA domain; Region: AAA_31; pfam13614 164757001796 P-loop; other site 164757001797 Magnesium ion binding site [ion binding]; other site 164757001798 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 164757001799 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757001800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757001801 catalytic residue [active] 164757001802 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757001803 Homeodomain-like domain; Region: HTH_23; cl17451 164757001804 Clp amino terminal domain; Region: Clp_N; pfam02861 164757001805 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 164757001806 UbiA prenyltransferase family; Region: UbiA; pfam01040 164757001807 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 164757001808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757001809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757001810 NAD(P) binding site [chemical binding]; other site 164757001811 active site 164757001812 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 164757001813 Nitronate monooxygenase; Region: NMO; pfam03060 164757001814 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757001815 FMN binding site [chemical binding]; other site 164757001816 substrate binding site [chemical binding]; other site 164757001817 putative catalytic residue [active] 164757001818 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 164757001819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757001820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757001821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757001822 dimer interface [polypeptide binding]; other site 164757001823 phosphorylation site [posttranslational modification] 164757001824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757001825 ATP binding site [chemical binding]; other site 164757001826 Mg2+ binding site [ion binding]; other site 164757001827 G-X-G motif; other site 164757001828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757001830 active site 164757001831 phosphorylation site [posttranslational modification] 164757001832 intermolecular recognition site; other site 164757001833 dimerization interface [polypeptide binding]; other site 164757001834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757001835 DNA binding site [nucleotide binding] 164757001836 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 164757001837 Ligand binding site; other site 164757001838 Putative Catalytic site; other site 164757001839 DXD motif; other site 164757001840 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 164757001841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757001842 S-adenosylmethionine binding site [chemical binding]; other site 164757001843 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 164757001844 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 164757001845 Moco binding site; other site 164757001846 metal coordination site [ion binding]; other site 164757001847 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 164757001848 cyanate hydratase; Validated; Region: PRK02866 164757001849 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 164757001850 oligomer interface [polypeptide binding]; other site 164757001851 active site 164757001852 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 164757001853 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 164757001854 putative molybdopterin cofactor binding site [chemical binding]; other site 164757001855 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 164757001856 putative molybdopterin cofactor binding site; other site 164757001857 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757001858 Ligand Binding Site [chemical binding]; other site 164757001859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757001860 Ligand Binding Site [chemical binding]; other site 164757001861 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 164757001862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757001863 dimerization interface [polypeptide binding]; other site 164757001864 putative DNA binding site [nucleotide binding]; other site 164757001865 Predicted transcriptional regulator [Transcription]; Region: COG2345 164757001866 putative Zn2+ binding site [ion binding]; other site 164757001867 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 164757001868 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 164757001869 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 164757001870 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 164757001871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757001872 active site 164757001873 CoA binding site [chemical binding]; other site 164757001874 AMP binding site [chemical binding]; other site 164757001875 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 164757001876 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 164757001877 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 164757001878 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757001879 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757001880 active site 164757001881 short chain dehydrogenase; Provisional; Region: PRK05866 164757001882 classical (c) SDRs; Region: SDR_c; cd05233 164757001883 NAD(P) binding site [chemical binding]; other site 164757001884 active site 164757001885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001887 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757001888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757001889 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 164757001890 substrate binding site [chemical binding]; other site 164757001891 oxyanion hole (OAH) forming residues; other site 164757001892 trimer interface [polypeptide binding]; other site 164757001893 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 164757001894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757001895 motif II; other site 164757001896 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 164757001897 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 164757001898 DNA binding residues [nucleotide binding] 164757001899 acyl-CoA synthetase; Validated; Region: PRK06188 164757001900 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757001901 putative active site [active] 164757001902 putative CoA binding site [chemical binding]; other site 164757001903 putative AMP binding site [chemical binding]; other site 164757001904 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 164757001905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 164757001906 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 164757001907 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 164757001908 active site 164757001909 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757001910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757001911 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757001912 acyl-activating enzyme (AAE) consensus motif; other site 164757001913 acyl-activating enzyme (AAE) consensus motif; other site 164757001914 putative AMP binding site [chemical binding]; other site 164757001915 putative active site [active] 164757001916 putative CoA binding site [chemical binding]; other site 164757001917 O-succinylbenzoate synthase; Provisional; Region: PRK02901 164757001918 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 164757001919 active site 164757001920 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757001921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757001922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757001923 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 164757001924 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 164757001925 conserved cys residue [active] 164757001926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757001927 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 164757001928 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 164757001929 conserved cys residue [active] 164757001930 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 164757001931 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757001932 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757001933 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757001934 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 164757001935 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 164757001936 dimer interface [polypeptide binding]; other site 164757001937 tetramer interface [polypeptide binding]; other site 164757001938 PYR/PP interface [polypeptide binding]; other site 164757001939 TPP binding site [chemical binding]; other site 164757001940 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 164757001941 TPP-binding site; other site 164757001942 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 164757001943 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757001944 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 164757001945 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757001946 NAD binding site [chemical binding]; other site 164757001947 catalytic Zn binding site [ion binding]; other site 164757001948 structural Zn binding site [ion binding]; other site 164757001949 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 164757001950 catalytic residues [active] 164757001951 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_3; cd06228 164757001952 putative active site [active] 164757001953 Zn binding site [ion binding]; other site 164757001954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757001955 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 164757001956 short chain dehydrogenase; Provisional; Region: PRK08263 164757001957 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757001958 NADP binding site [chemical binding]; other site 164757001959 active site 164757001960 steroid binding site; other site 164757001961 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 164757001962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757001963 S-adenosylmethionine binding site [chemical binding]; other site 164757001964 Uncharacterized conserved protein [Function unknown]; Region: COG3349 164757001965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757001966 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 164757001967 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 164757001968 putative active site [active] 164757001969 metal binding site [ion binding]; metal-binding site 164757001970 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 164757001971 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 164757001972 Predicted membrane protein [Function unknown]; Region: COG2860 164757001973 UPF0126 domain; Region: UPF0126; pfam03458 164757001974 UPF0126 domain; Region: UPF0126; pfam03458 164757001975 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 164757001976 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 164757001977 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 164757001978 putative active site [active] 164757001979 catalytic site [active] 164757001980 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 164757001981 putative active site [active] 164757001982 catalytic site [active] 164757001983 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 164757001984 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757001985 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 164757001986 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 164757001987 substrate binding pocket [chemical binding]; other site 164757001988 chain length determination region; other site 164757001989 substrate-Mg2+ binding site; other site 164757001990 catalytic residues [active] 164757001991 aspartate-rich region 1; other site 164757001992 active site lid residues [active] 164757001993 aspartate-rich region 2; other site 164757001994 heat shock protein HtpX; Provisional; Region: PRK03072 164757001995 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 164757001996 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 164757001997 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 164757001998 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 164757001999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 164757002000 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 164757002001 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 164757002002 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 164757002003 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 164757002004 FOG: PKD repeat [General function prediction only]; Region: COG3291 164757002005 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 164757002006 AAA ATPase domain; Region: AAA_16; pfam13191 164757002007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 164757002008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002010 DNA binding residues [nucleotide binding] 164757002011 dimerization interface [polypeptide binding]; other site 164757002012 MarR family; Region: MarR_2; pfam12802 164757002013 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757002014 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757002015 active site 164757002016 ATP binding site [chemical binding]; other site 164757002017 substrate binding site [chemical binding]; other site 164757002018 activation loop (A-loop); other site 164757002019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757002020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757002021 substrate binding pocket [chemical binding]; other site 164757002022 membrane-bound complex binding site; other site 164757002023 hinge residues; other site 164757002024 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 164757002025 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 164757002026 dimer interface [polypeptide binding]; other site 164757002027 active site 164757002028 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 164757002029 PEGA domain; Region: PEGA; pfam08308 164757002030 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757002031 Cytochrome P450; Region: p450; cl12078 164757002032 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757002034 S-adenosylmethionine binding site [chemical binding]; other site 164757002035 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757002036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757002037 S-adenosylmethionine binding site [chemical binding]; other site 164757002038 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 164757002039 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 164757002040 putative active site [active] 164757002041 putative ligand binding site [chemical binding]; other site 164757002042 putative NAD(P) binding site [chemical binding]; other site 164757002043 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 164757002044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757002045 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757002046 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757002047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757002048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757002049 active site 164757002050 ATP binding site [chemical binding]; other site 164757002051 substrate binding site [chemical binding]; other site 164757002052 activation loop (A-loop); other site 164757002053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757002054 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757002055 cyclase homology domain; Region: CHD; cd07302 164757002056 nucleotidyl binding site; other site 164757002057 metal binding site [ion binding]; metal-binding site 164757002058 dimer interface [polypeptide binding]; other site 164757002059 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 164757002060 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757002061 PQQ-like domain; Region: PQQ_2; pfam13360 164757002062 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 164757002063 active site 164757002064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757002066 active site 164757002067 phosphorylation site [posttranslational modification] 164757002068 intermolecular recognition site; other site 164757002069 dimerization interface [polypeptide binding]; other site 164757002070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002071 DNA binding residues [nucleotide binding] 164757002072 dimerization interface [polypeptide binding]; other site 164757002073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 164757002074 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 164757002075 ATP binding site [chemical binding]; other site 164757002076 G-X-G motif; other site 164757002077 Proteins of 100 residues with WXG; Region: WXG100; cl02005 164757002078 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 164757002079 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 164757002080 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757002081 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757002082 Double zinc ribbon; Region: DZR; pfam12773 164757002083 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 164757002084 RDD family; Region: RDD; pfam06271 164757002085 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 164757002086 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 164757002087 metal ion-dependent adhesion site (MIDAS); other site 164757002088 Protein phosphatase 2C; Region: PP2C_2; pfam13672 164757002089 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 164757002090 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757002091 substrate binding site [chemical binding]; other site 164757002092 activation loop (A-loop); other site 164757002093 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 164757002094 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 164757002095 putative active site [active] 164757002096 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757002097 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 164757002098 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 164757002099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757002100 dimer interface [polypeptide binding]; other site 164757002101 conserved gate region; other site 164757002102 ABC-ATPase subunit interface; other site 164757002103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757002104 ATP-binding site [chemical binding]; other site 164757002105 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 164757002106 Restriction endonuclease; Region: Mrr_cat; pfam04471 164757002107 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 164757002108 mismatch recognition site; other site 164757002109 additional DNA contacts [nucleotide binding]; other site 164757002110 active site 164757002111 zinc binding site [ion binding]; other site 164757002112 DNA intercalation site [nucleotide binding]; other site 164757002113 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 164757002114 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 164757002115 cofactor binding site; other site 164757002116 DNA binding site [nucleotide binding] 164757002117 substrate interaction site [chemical binding]; other site 164757002118 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 164757002119 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 164757002120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757002121 ATP binding site [chemical binding]; other site 164757002122 putative Mg++ binding site [ion binding]; other site 164757002123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757002124 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 164757002125 nucleotide binding region [chemical binding]; other site 164757002126 ATP-binding site [chemical binding]; other site 164757002127 DEAD-like helicases superfamily; Region: DEXDc; smart00487 164757002128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757002129 ATP binding site [chemical binding]; other site 164757002130 putative Mg++ binding site [ion binding]; other site 164757002131 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 164757002132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757002133 nucleotide binding region [chemical binding]; other site 164757002134 ATP-binding site [chemical binding]; other site 164757002135 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 164757002136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002138 Permease; Region: Permease; pfam02405 164757002139 Permease; Region: Permease; pfam02405 164757002140 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757002141 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 164757002142 mce related protein; Region: MCE; pfam02470 164757002143 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757002144 mce related protein; Region: MCE; pfam02470 164757002145 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757002146 mce related protein; Region: MCE; pfam02470 164757002147 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757002148 mce related protein; Region: MCE; pfam02470 164757002149 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 164757002150 mce related protein; Region: MCE; pfam02470 164757002151 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 164757002152 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 164757002153 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 164757002154 putative active site [active] 164757002155 Nuclease-related domain; Region: NERD; pfam08378 164757002156 Part of AAA domain; Region: AAA_19; pfam13245 164757002157 Family description; Region: UvrD_C_2; pfam13538 164757002158 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 164757002159 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 164757002160 active site 164757002161 catalytic residues [active] 164757002162 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 164757002163 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 164757002164 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 164757002165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757002168 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757002169 NAD(P) binding site [chemical binding]; other site 164757002170 active site 164757002171 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 164757002172 Mechanosensitive ion channel; Region: MS_channel; pfam00924 164757002173 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 164757002174 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 164757002175 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757002176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 164757002177 protein binding site [polypeptide binding]; other site 164757002178 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 164757002179 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 164757002180 EamA-like transporter family; Region: EamA; pfam00892 164757002181 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 164757002182 EamA-like transporter family; Region: EamA; pfam00892 164757002183 short chain dehydrogenase; Provisional; Region: PRK05866 164757002184 classical (c) SDRs; Region: SDR_c; cd05233 164757002185 NAD(P) binding site [chemical binding]; other site 164757002186 active site 164757002187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 164757002188 Microsomal signal peptidase 12 kDa subunit (SPC12); Region: SPC12; pfam06645 164757002189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002191 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757002192 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757002193 Uncharacterized conserved protein [Function unknown]; Region: COG3391 164757002194 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 164757002195 PIF1-like helicase; Region: PIF1; pfam05970 164757002196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757002197 Walker A motif; other site 164757002198 ATP binding site [chemical binding]; other site 164757002199 Walker B motif; other site 164757002200 Family description; Region: UvrD_C_2; pfam13538 164757002201 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 164757002202 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 164757002203 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757002204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 164757002205 P-loop containing region of AAA domain; Region: AAA_29; cl17516 164757002206 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 164757002207 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 164757002208 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 164757002209 Creatinine amidohydrolase; Region: Creatininase; pfam02633 164757002210 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 164757002211 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 164757002212 NAD binding site [chemical binding]; other site 164757002213 ligand binding site [chemical binding]; other site 164757002214 catalytic site [active] 164757002215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757002216 dimer interface [polypeptide binding]; other site 164757002217 conserved gate region; other site 164757002218 putative PBP binding loops; other site 164757002219 ABC-ATPase subunit interface; other site 164757002220 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757002221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757002222 Walker A/P-loop; other site 164757002223 ATP binding site [chemical binding]; other site 164757002224 Q-loop/lid; other site 164757002225 ABC transporter signature motif; other site 164757002226 Walker B; other site 164757002227 D-loop; other site 164757002228 H-loop/switch region; other site 164757002229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757002230 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757002231 substrate binding pocket [chemical binding]; other site 164757002232 membrane-bound complex binding site; other site 164757002233 hinge residues; other site 164757002234 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 164757002235 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757002236 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 164757002237 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 164757002238 putative DNA binding site [nucleotide binding]; other site 164757002239 putative Zn2+ binding site [ion binding]; other site 164757002240 AsnC family; Region: AsnC_trans_reg; pfam01037 164757002241 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 164757002242 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 164757002243 haloalkane dehalogenase; Provisional; Region: PRK03592 164757002244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757002245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002249 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757002250 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757002251 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 164757002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757002253 NAD(P) binding site [chemical binding]; other site 164757002254 active site 164757002255 Uncharacterized conserved protein [Function unknown]; Region: COG1434 164757002256 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 164757002257 putative active site [active] 164757002258 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 164757002259 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757002260 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757002261 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 164757002262 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 164757002263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757002264 putative PBP binding loops; other site 164757002265 dimer interface [polypeptide binding]; other site 164757002266 ABC-ATPase subunit interface; other site 164757002267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 164757002268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757002269 dimer interface [polypeptide binding]; other site 164757002270 conserved gate region; other site 164757002271 putative PBP binding loops; other site 164757002272 ABC-ATPase subunit interface; other site 164757002273 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 164757002274 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 164757002275 Walker A/P-loop; other site 164757002276 ATP binding site [chemical binding]; other site 164757002277 Q-loop/lid; other site 164757002278 ABC transporter signature motif; other site 164757002279 Walker B; other site 164757002280 D-loop; other site 164757002281 H-loop/switch region; other site 164757002282 TOBE domain; Region: TOBE_2; pfam08402 164757002283 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757002284 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 164757002285 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757002286 active site 164757002287 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 164757002288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757002289 active site 164757002290 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 164757002291 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 164757002292 active site 164757002293 dimer interface [polypeptide binding]; other site 164757002294 non-prolyl cis peptide bond; other site 164757002295 insertion regions; other site 164757002296 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 164757002297 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 164757002298 active site 164757002299 non-prolyl cis peptide bond; other site 164757002300 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 164757002301 Sulfatase; Region: Sulfatase; cl17466 164757002302 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757002303 hydrophobic ligand binding site; other site 164757002304 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 164757002305 DNA binding residues [nucleotide binding] 164757002306 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757002307 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 164757002308 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 164757002309 Sulfate transporter family; Region: Sulfate_transp; pfam00916 164757002310 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 164757002311 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 164757002312 AAA domain; Region: AAA_30; pfam13604 164757002313 Family description; Region: UvrD_C_2; pfam13538 164757002314 LabA_like proteins; Region: LabA_like; cd06167 164757002315 putative metal binding site [ion binding]; other site 164757002316 Uncharacterized conserved protein [Function unknown]; Region: COG1432 164757002317 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 164757002318 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757002319 anti sigma factor interaction site; other site 164757002320 regulatory phosphorylation site [posttranslational modification]; other site 164757002321 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 164757002322 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 164757002323 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 164757002324 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 164757002325 HD domain; Region: HD_4; pfam13328 164757002326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757002327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757002328 putative substrate translocation pore; other site 164757002329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757002330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757002331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757002332 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 164757002333 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 164757002334 oligomer interface [polypeptide binding]; other site 164757002335 metal binding site [ion binding]; metal-binding site 164757002336 metal binding site [ion binding]; metal-binding site 164757002337 putative Cl binding site [ion binding]; other site 164757002338 aspartate ring; other site 164757002339 basic sphincter; other site 164757002340 hydrophobic gate; other site 164757002341 periplasmic entrance; other site 164757002342 HD domain; Region: HD_5; pfam13487 164757002343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757002344 Zn2+ binding site [ion binding]; other site 164757002345 Mg2+ binding site [ion binding]; other site 164757002346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002348 DNA binding residues [nucleotide binding] 164757002349 dimerization interface [polypeptide binding]; other site 164757002350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002352 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757002353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757002354 substrate binding site [chemical binding]; other site 164757002355 oxyanion hole (OAH) forming residues; other site 164757002356 trimer interface [polypeptide binding]; other site 164757002357 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 164757002358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757002359 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757002360 Walker A motif; other site 164757002361 ATP binding site [chemical binding]; other site 164757002362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002364 DNA binding residues [nucleotide binding] 164757002365 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 164757002366 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 164757002367 phage tail protein domain; Region: tail_TIGR02242 164757002368 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 164757002369 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 164757002370 Phage protein D [General function prediction only]; Region: COG3500 164757002371 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 164757002372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 164757002373 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 164757002374 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 164757002375 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 164757002376 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 164757002377 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 164757002378 Phage-related protein [Function unknown]; Region: COG5412 164757002379 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 164757002380 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 164757002381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757002382 TPR repeat; Region: TPR_11; pfam13414 164757002383 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 164757002384 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757002386 Walker A motif; other site 164757002387 ATP binding site [chemical binding]; other site 164757002388 Walker B motif; other site 164757002389 arginine finger; other site 164757002390 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 164757002391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002393 DNA binding residues [nucleotide binding] 164757002394 dimerization interface [polypeptide binding]; other site 164757002395 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 164757002396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757002397 Transcriptional regulator; Region: Rrf2; cl17282 164757002398 Rrf2 family protein; Region: rrf2_super; TIGR00738 164757002399 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 164757002400 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 164757002401 heme-binding site [chemical binding]; other site 164757002402 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 164757002403 FAD binding pocket [chemical binding]; other site 164757002404 FAD binding motif [chemical binding]; other site 164757002405 phosphate binding motif [ion binding]; other site 164757002406 beta-alpha-beta structure motif; other site 164757002407 NAD binding pocket [chemical binding]; other site 164757002408 Heme binding pocket [chemical binding]; other site 164757002409 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 164757002410 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757002411 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 164757002412 active site 164757002413 catalytic site [active] 164757002414 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757002415 active site 164757002416 catalytic site [active] 164757002417 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 164757002418 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 164757002419 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 164757002420 putative homodimer interface [polypeptide binding]; other site 164757002421 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 164757002422 heterodimer interface [polypeptide binding]; other site 164757002423 homodimer interface [polypeptide binding]; other site 164757002424 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 164757002425 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 164757002426 23S rRNA interface [nucleotide binding]; other site 164757002427 L7/L12 interface [polypeptide binding]; other site 164757002428 putative thiostrepton binding site; other site 164757002429 L25 interface [polypeptide binding]; other site 164757002430 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 164757002431 mRNA/rRNA interface [nucleotide binding]; other site 164757002432 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 164757002433 Chain length determinant protein; Region: Wzz; cl15801 164757002434 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 164757002435 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757002436 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757002437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757002438 NAD(P) binding site [chemical binding]; other site 164757002439 active site 164757002440 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 164757002441 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 164757002442 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 164757002443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 164757002444 active site 164757002445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757002446 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 164757002447 putative trimer interface [polypeptide binding]; other site 164757002448 putative CoA binding site [chemical binding]; other site 164757002449 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757002450 Low molecular weight phosphatase family; Region: LMWPc; cl00105 164757002451 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 164757002452 active site 164757002453 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 164757002454 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 164757002455 NAD(P) binding site [chemical binding]; other site 164757002456 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 164757002457 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 164757002458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 164757002459 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 164757002460 PE-PPE domain; Region: PE-PPE; pfam08237 164757002461 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757002463 S-adenosylmethionine binding site [chemical binding]; other site 164757002464 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757002465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757002466 S-adenosylmethionine binding site [chemical binding]; other site 164757002467 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757002468 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757002469 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757002470 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 164757002471 ABC1 family; Region: ABC1; pfam03109 164757002472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 164757002473 active site 164757002474 ATP binding site [chemical binding]; other site 164757002475 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757002476 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 164757002477 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757002478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002479 Protein of unknown function (DUF664); Region: DUF664; pfam04978 164757002480 DinB superfamily; Region: DinB_2; pfam12867 164757002481 DinB superfamily; Region: DinB_2; pfam12867 164757002482 short chain dehydrogenase; Provisional; Region: PRK06180 164757002483 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757002484 NADP binding site [chemical binding]; other site 164757002485 active site 164757002486 steroid binding site; other site 164757002487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002491 Predicted transcriptional regulator [Transcription]; Region: COG2378 164757002492 HTH domain; Region: HTH_11; pfam08279 164757002493 WYL domain; Region: WYL; pfam13280 164757002494 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 164757002495 putative catalytic site [active] 164757002496 putative metal binding site [ion binding]; other site 164757002497 putative phosphate binding site [ion binding]; other site 164757002498 Filamin-type immunoglobulin domains; Region: IG_FLMN; smart00557 164757002499 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 164757002500 active site 164757002501 catalytic site [active] 164757002502 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 164757002503 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 164757002504 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 164757002505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 164757002506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 164757002507 nucleotide binding site [chemical binding]; other site 164757002508 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 164757002509 23S rRNA interface [nucleotide binding]; other site 164757002510 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 164757002511 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 164757002512 core dimer interface [polypeptide binding]; other site 164757002513 peripheral dimer interface [polypeptide binding]; other site 164757002514 L10 interface [polypeptide binding]; other site 164757002515 L11 interface [polypeptide binding]; other site 164757002516 putative EF-Tu interaction site [polypeptide binding]; other site 164757002517 putative EF-G interaction site [polypeptide binding]; other site 164757002518 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 164757002519 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 164757002520 Walker A/P-loop; other site 164757002521 ATP binding site [chemical binding]; other site 164757002522 Q-loop/lid; other site 164757002523 ABC transporter signature motif; other site 164757002524 Walker B; other site 164757002525 D-loop; other site 164757002526 H-loop/switch region; other site 164757002527 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 164757002528 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 164757002529 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 164757002530 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 164757002531 RPB10 interaction site [polypeptide binding]; other site 164757002532 RPB1 interaction site [polypeptide binding]; other site 164757002533 RPB11 interaction site [polypeptide binding]; other site 164757002534 RPB3 interaction site [polypeptide binding]; other site 164757002535 RPB12 interaction site [polypeptide binding]; other site 164757002536 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 164757002537 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 164757002538 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 164757002539 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 164757002540 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 164757002541 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 164757002542 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 164757002543 G-loop; other site 164757002544 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 164757002545 DNA binding site [nucleotide binding] 164757002546 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 164757002547 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 164757002548 endonuclease IV; Provisional; Region: PRK01060 164757002549 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 164757002550 AP (apurinic/apyrimidinic) site pocket; other site 164757002551 DNA interaction; other site 164757002552 Metal-binding active site; metal-binding site 164757002553 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 164757002554 active site 164757002555 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 164757002556 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 164757002557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757002558 active site 164757002559 enoyl-CoA hydratase; Provisional; Region: PRK12478 164757002560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757002561 substrate binding site [chemical binding]; other site 164757002562 oxyanion hole (OAH) forming residues; other site 164757002563 trimer interface [polypeptide binding]; other site 164757002564 PaaX-like protein; Region: PaaX; pfam07848 164757002565 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 164757002566 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757002567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757002568 substrate binding site [chemical binding]; other site 164757002569 oxyanion hole (OAH) forming residues; other site 164757002570 trimer interface [polypeptide binding]; other site 164757002571 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 164757002572 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 164757002573 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 164757002574 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 164757002575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002577 WHG domain; Region: WHG; pfam13305 164757002578 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 164757002579 S17 interaction site [polypeptide binding]; other site 164757002580 S8 interaction site; other site 164757002581 16S rRNA interaction site [nucleotide binding]; other site 164757002582 streptomycin interaction site [chemical binding]; other site 164757002583 23S rRNA interaction site [nucleotide binding]; other site 164757002584 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 164757002585 30S ribosomal protein S7; Validated; Region: PRK05302 164757002586 elongation factor G; Reviewed; Region: PRK00007 164757002587 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 164757002588 G1 box; other site 164757002589 putative GEF interaction site [polypeptide binding]; other site 164757002590 GTP/Mg2+ binding site [chemical binding]; other site 164757002591 Switch I region; other site 164757002592 G2 box; other site 164757002593 G3 box; other site 164757002594 Switch II region; other site 164757002595 G4 box; other site 164757002596 G5 box; other site 164757002597 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 164757002598 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 164757002599 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 164757002600 elongation factor Tu; Reviewed; Region: PRK00049 164757002601 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 164757002602 G1 box; other site 164757002603 GEF interaction site [polypeptide binding]; other site 164757002604 GTP/Mg2+ binding site [chemical binding]; other site 164757002605 Switch I region; other site 164757002606 G2 box; other site 164757002607 G3 box; other site 164757002608 Switch II region; other site 164757002609 G4 box; other site 164757002610 G5 box; other site 164757002611 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 164757002612 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 164757002613 Antibiotic Binding Site [chemical binding]; other site 164757002614 Cutinase; Region: Cutinase; pfam01083 164757002615 Short C-terminal domain; Region: SHOCT; pfam09851 164757002616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002617 Ligand Binding Site [chemical binding]; other site 164757002618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002619 Ligand Binding Site [chemical binding]; other site 164757002620 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757002621 classical (c) SDRs; Region: SDR_c; cd05233 164757002622 NAD(P) binding site [chemical binding]; other site 164757002623 active site 164757002624 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757002625 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 164757002626 inhibitor-cofactor binding pocket; inhibition site 164757002627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757002628 catalytic residue [active] 164757002629 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 164757002630 Amidinotransferase; Region: Amidinotransf; pfam02274 164757002631 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 164757002632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757002633 putative DNA binding site [nucleotide binding]; other site 164757002634 putative Zn2+ binding site [ion binding]; other site 164757002635 AsnC family; Region: AsnC_trans_reg; pfam01037 164757002636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757002637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757002638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757002639 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 164757002640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757002641 putative dimer interface [polypeptide binding]; other site 164757002642 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 164757002643 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 164757002644 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 164757002645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757002646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757002647 DNA binding residues [nucleotide binding] 164757002648 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 164757002649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002650 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 164757002651 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 164757002652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757002653 FeS/SAM binding site; other site 164757002654 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 164757002655 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 164757002656 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757002657 phosphate binding site [ion binding]; other site 164757002658 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 164757002659 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 164757002660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757002661 active site 164757002662 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 164757002663 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 164757002664 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 164757002665 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 164757002666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757002667 putative substrate translocation pore; other site 164757002668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002670 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757002671 Cytochrome P450; Region: p450; cl12078 164757002672 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757002673 Cytochrome P450; Region: p450; cl12078 164757002674 Carboxylesterase family; Region: COesterase; pfam00135 164757002675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757002676 substrate binding pocket [chemical binding]; other site 164757002677 catalytic triad [active] 164757002678 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 164757002679 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 164757002680 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 164757002681 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 164757002682 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 164757002683 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 164757002684 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 164757002685 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 164757002686 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 164757002687 putative translocon binding site; other site 164757002688 protein-rRNA interface [nucleotide binding]; other site 164757002689 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 164757002690 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 164757002691 G-X-X-G motif; other site 164757002692 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 164757002693 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 164757002694 23S rRNA interface [nucleotide binding]; other site 164757002695 5S rRNA interface [nucleotide binding]; other site 164757002696 putative antibiotic binding site [chemical binding]; other site 164757002697 L25 interface [polypeptide binding]; other site 164757002698 L27 interface [polypeptide binding]; other site 164757002699 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 164757002700 putative translocon interaction site; other site 164757002701 23S rRNA interface [nucleotide binding]; other site 164757002702 signal recognition particle (SRP54) interaction site; other site 164757002703 L23 interface [polypeptide binding]; other site 164757002704 trigger factor interaction site; other site 164757002705 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 164757002706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002708 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 164757002709 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 164757002710 Sulfatase; Region: Sulfatase; pfam00884 164757002711 Uncharacterized conserved protein [Function unknown]; Region: COG1262 164757002712 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 164757002713 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 164757002714 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 164757002715 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 164757002716 RNA binding site [nucleotide binding]; other site 164757002717 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 164757002718 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 164757002719 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 164757002720 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 164757002721 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 164757002722 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 164757002723 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 164757002724 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 164757002725 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 164757002726 5S rRNA interface [nucleotide binding]; other site 164757002727 L27 interface [polypeptide binding]; other site 164757002728 23S rRNA interface [nucleotide binding]; other site 164757002729 L5 interface [polypeptide binding]; other site 164757002730 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 164757002731 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 164757002732 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 164757002733 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 164757002734 23S rRNA binding site [nucleotide binding]; other site 164757002735 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 164757002736 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 164757002737 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757002738 NADP binding site [chemical binding]; other site 164757002739 active site 164757002740 steroid binding site; other site 164757002741 Cupin; Region: Cupin_6; pfam12852 164757002742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757002743 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757002744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757002745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757002746 Transposase; Region: HTH_Tnp_1; pfam01527 164757002747 putative transposase OrfB; Reviewed; Region: PHA02517 164757002748 HTH-like domain; Region: HTH_21; pfam13276 164757002749 Integrase core domain; Region: rve; pfam00665 164757002750 Integrase core domain; Region: rve_3; pfam13683 164757002751 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 164757002752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757002753 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 164757002754 tandem repeat interface [polypeptide binding]; other site 164757002755 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 164757002756 oligomer interface [polypeptide binding]; other site 164757002757 active site residues [active] 164757002758 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 164757002759 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 164757002760 tandem repeat interface [polypeptide binding]; other site 164757002761 oligomer interface [polypeptide binding]; other site 164757002762 active site residues [active] 164757002763 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757002764 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 164757002765 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757002766 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 164757002767 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757002768 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 164757002769 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 164757002770 SecY translocase; Region: SecY; pfam00344 164757002771 adenylate kinase; Reviewed; Region: adk; PRK00279 164757002772 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 164757002773 AMP-binding site [chemical binding]; other site 164757002774 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 164757002775 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 164757002776 active site 164757002777 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 164757002778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757002779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757002780 DNA binding residues [nucleotide binding] 164757002781 Putative zinc-finger; Region: zf-HC2; pfam13490 164757002782 MarR family; Region: MarR; pfam01047 164757002783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757002784 NmrA-like family; Region: NmrA; pfam05368 164757002785 NAD(P) binding site [chemical binding]; other site 164757002786 active site 164757002787 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757002788 MarR family; Region: MarR_2; pfam12802 164757002789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757002790 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 164757002791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 164757002792 Histidine kinase; Region: HisKA_3; pfam07730 164757002793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757002794 ATP binding site [chemical binding]; other site 164757002795 Mg2+ binding site [ion binding]; other site 164757002796 G-X-G motif; other site 164757002797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757002799 active site 164757002800 phosphorylation site [posttranslational modification] 164757002801 intermolecular recognition site; other site 164757002802 dimerization interface [polypeptide binding]; other site 164757002803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002804 DNA binding residues [nucleotide binding] 164757002805 dimerization interface [polypeptide binding]; other site 164757002806 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 164757002807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757002808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757002809 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 164757002810 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 164757002811 malonyl-CoA binding site [chemical binding]; other site 164757002812 dimer interface [polypeptide binding]; other site 164757002813 active site 164757002814 product binding site; other site 164757002815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 164757002816 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 164757002817 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757002818 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 164757002819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757002820 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 164757002821 substrate binding pocket [chemical binding]; other site 164757002822 FAD binding site [chemical binding]; other site 164757002823 catalytic base [active] 164757002824 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 164757002825 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 164757002826 tetrameric interface [polypeptide binding]; other site 164757002827 NAD binding site [chemical binding]; other site 164757002828 catalytic residues [active] 164757002829 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 164757002830 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 164757002831 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 164757002832 NAD binding site [chemical binding]; other site 164757002833 substrate binding site [chemical binding]; other site 164757002834 homodimer interface [polypeptide binding]; other site 164757002835 active site 164757002836 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 164757002837 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 164757002838 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 164757002839 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 164757002840 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 164757002841 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 164757002842 ligand binding site [chemical binding]; other site 164757002843 flexible hinge region; other site 164757002844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757002846 ATP binding site [chemical binding]; other site 164757002847 Mg2+ binding site [ion binding]; other site 164757002848 G-X-G motif; other site 164757002849 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 164757002850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757002851 active site 164757002852 phosphorylation site [posttranslational modification] 164757002853 intermolecular recognition site; other site 164757002854 dimerization interface [polypeptide binding]; other site 164757002855 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 164757002856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757002857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757002858 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757002859 hydrophobic ligand binding site; other site 164757002860 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757002861 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757002862 NAD(P) binding site [chemical binding]; other site 164757002863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 164757002864 Predicted kinase [General function prediction only]; Region: COG0645 164757002865 AAA domain; Region: AAA_17; pfam13207 164757002866 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757002867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757002868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757002869 active site 164757002870 phosphorylation site [posttranslational modification] 164757002871 intermolecular recognition site; other site 164757002872 dimerization interface [polypeptide binding]; other site 164757002873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757002874 DNA binding residues [nucleotide binding] 164757002875 dimerization interface [polypeptide binding]; other site 164757002876 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757002877 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 164757002878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 164757002879 Histidine kinase; Region: HisKA_3; pfam07730 164757002880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757002881 ATP binding site [chemical binding]; other site 164757002882 G-X-G motif; other site 164757002883 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757002884 FMN binding site [chemical binding]; other site 164757002885 dimer interface [polypeptide binding]; other site 164757002886 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 164757002887 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757002888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757002889 active site 164757002890 Erythromycin esterase; Region: Erythro_esteras; pfam05139 164757002891 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 164757002892 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 164757002893 putative dimer interface [polypeptide binding]; other site 164757002894 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 164757002895 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 164757002896 ATP cone domain; Region: ATP-cone; pfam03477 164757002897 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 164757002898 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 164757002899 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 164757002900 active site 164757002901 dimer interface [polypeptide binding]; other site 164757002902 effector binding site; other site 164757002903 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002904 Ligand Binding Site [chemical binding]; other site 164757002905 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757002906 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 164757002907 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 164757002908 tetramer interface [polypeptide binding]; other site 164757002909 TPP-binding site [chemical binding]; other site 164757002910 heterodimer interface [polypeptide binding]; other site 164757002911 phosphorylation loop region [posttranslational modification] 164757002912 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 164757002913 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 164757002914 TPP binding site [chemical binding]; other site 164757002915 alpha subunit interface [polypeptide binding]; other site 164757002916 heterodimer interface [polypeptide binding]; other site 164757002917 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 164757002918 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 164757002919 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 164757002920 E3 interaction surface; other site 164757002921 lipoyl attachment site [posttranslational modification]; other site 164757002922 e3 binding domain; Region: E3_binding; pfam02817 164757002923 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 164757002924 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 164757002925 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 164757002926 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 164757002927 putative NAD(P) binding site [chemical binding]; other site 164757002928 putative substrate binding site [chemical binding]; other site 164757002929 catalytic Zn binding site [ion binding]; other site 164757002930 structural Zn binding site [ion binding]; other site 164757002931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002932 Ligand Binding Site [chemical binding]; other site 164757002933 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002934 Ligand Binding Site [chemical binding]; other site 164757002935 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 164757002936 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757002937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757002938 Transporter associated domain; Region: CorC_HlyC; smart01091 164757002939 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 164757002940 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 164757002941 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757002942 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 164757002943 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757002944 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 164757002945 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002946 Ligand Binding Site [chemical binding]; other site 164757002947 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002948 Ligand Binding Site [chemical binding]; other site 164757002949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 164757002950 FOG: CBS domain [General function prediction only]; Region: COG0517 164757002951 Divalent cation transporter; Region: MgtE; cl00786 164757002952 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002953 Ligand Binding Site [chemical binding]; other site 164757002954 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002955 Ligand Binding Site [chemical binding]; other site 164757002956 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757002957 Ligand Binding Site [chemical binding]; other site 164757002958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 164757002959 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 164757002960 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757002961 dimer interface [polypeptide binding]; other site 164757002962 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 164757002963 rRNA binding site [nucleotide binding]; other site 164757002964 predicted 30S ribosome binding site; other site 164757002965 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 164757002966 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 164757002967 30S ribosomal protein S13; Region: bact_S13; TIGR03631 164757002968 30S ribosomal protein S11; Validated; Region: PRK05309 164757002969 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 164757002970 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 164757002971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 164757002972 RNA binding surface [nucleotide binding]; other site 164757002973 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 164757002974 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 164757002975 alphaNTD homodimer interface [polypeptide binding]; other site 164757002976 alphaNTD - beta interaction site [polypeptide binding]; other site 164757002977 alphaNTD - beta' interaction site [polypeptide binding]; other site 164757002978 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 164757002979 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 164757002980 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 164757002981 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 164757002982 dimerization interface 3.5A [polypeptide binding]; other site 164757002983 active site 164757002984 Cutinase; Region: Cutinase; pfam01083 164757002985 Cutinase; Region: Cutinase; pfam01083 164757002986 EamA-like transporter family; Region: EamA; pfam00892 164757002987 EamA-like transporter family; Region: EamA; pfam00892 164757002988 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 164757002989 CGNR zinc finger; Region: zf-CGNR; pfam11706 164757002990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757002991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757002992 metal binding site [ion binding]; metal-binding site 164757002993 active site 164757002994 I-site; other site 164757002995 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 164757002996 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 164757002997 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 164757002998 active site 164757002999 catalytic residues [active] 164757003000 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 164757003001 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 164757003002 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757003003 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 164757003004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757003005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757003006 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 164757003007 Proteins of 100 residues with WXG; Region: WXG100; cl02005 164757003008 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 164757003009 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 164757003010 23S rRNA interface [nucleotide binding]; other site 164757003011 L3 interface [polypeptide binding]; other site 164757003012 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 164757003013 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 164757003014 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 164757003015 active site 164757003016 substrate binding site [chemical binding]; other site 164757003017 metal binding site [ion binding]; metal-binding site 164757003018 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 164757003019 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757003020 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 164757003021 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 164757003022 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 164757003023 glutaminase active site [active] 164757003024 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 164757003025 dimer interface [polypeptide binding]; other site 164757003026 active site 164757003027 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 164757003028 dimer interface [polypeptide binding]; other site 164757003029 active site 164757003030 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 164757003031 putative hydrophobic ligand binding site [chemical binding]; other site 164757003032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757003033 putative DNA binding site [nucleotide binding]; other site 164757003034 dimerization interface [polypeptide binding]; other site 164757003035 putative Zn2+ binding site [ion binding]; other site 164757003036 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 164757003037 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757003038 Uncharacterized conserved protein [Function unknown]; Region: COG0062 164757003039 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 164757003040 putative substrate binding site [chemical binding]; other site 164757003041 putative ATP binding site [chemical binding]; other site 164757003042 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 164757003043 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 164757003044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757003045 catalytic residue [active] 164757003046 alanine racemase; Reviewed; Region: alr; PRK00053 164757003047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 164757003048 active site 164757003049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 164757003050 dimer interface [polypeptide binding]; other site 164757003051 substrate binding site [chemical binding]; other site 164757003052 catalytic residues [active] 164757003053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757003054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757003055 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757003056 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 164757003057 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 164757003058 Glycoprotease family; Region: Peptidase_M22; pfam00814 164757003059 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 164757003060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757003061 Coenzyme A binding pocket [chemical binding]; other site 164757003062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 164757003063 UGMP family protein; Validated; Region: PRK09604 164757003064 SnoaL-like domain; Region: SnoaL_4; pfam13577 164757003065 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 164757003066 oligomerisation interface [polypeptide binding]; other site 164757003067 mobile loop; other site 164757003068 roof hairpin; other site 164757003069 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 164757003070 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 164757003071 ring oligomerisation interface [polypeptide binding]; other site 164757003072 ATP/Mg binding site [chemical binding]; other site 164757003073 stacking interactions; other site 164757003074 hinge regions; other site 164757003075 MarR family; Region: MarR_2; cl17246 164757003076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757003077 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757003078 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 164757003079 putative NAD(P) binding site [chemical binding]; other site 164757003080 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 164757003081 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 164757003082 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 164757003083 Transcription factor WhiB; Region: Whib; pfam02467 164757003084 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 164757003085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757003086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757003087 DNA binding residues [nucleotide binding] 164757003088 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 164757003089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757003090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 164757003091 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 164757003092 active site 164757003093 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 164757003094 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757003095 phosphate binding site [ion binding]; other site 164757003096 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 164757003097 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 164757003098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757003099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 164757003100 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 164757003101 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 164757003102 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 164757003103 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 164757003104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757003105 motif II; other site 164757003106 GMP synthase; Reviewed; Region: guaA; PRK00074 164757003107 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 164757003108 AMP/PPi binding site [chemical binding]; other site 164757003109 candidate oxyanion hole; other site 164757003110 catalytic triad [active] 164757003111 potential glutamine specificity residues [chemical binding]; other site 164757003112 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 164757003113 ATP Binding subdomain [chemical binding]; other site 164757003114 Ligand Binding sites [chemical binding]; other site 164757003115 Dimerization subdomain; other site 164757003116 DNA Polymerase Y-family; Region: PolY_like; cd03468 164757003117 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 164757003118 DNA binding site [nucleotide binding] 164757003119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757003120 MarR family; Region: MarR; pfam01047 164757003121 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 164757003122 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 164757003123 active site 164757003124 MarR family; Region: MarR_2; pfam12802 164757003125 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757003126 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 164757003127 dimer interaction site [polypeptide binding]; other site 164757003128 substrate-binding tunnel; other site 164757003129 active site 164757003130 catalytic site [active] 164757003131 substrate binding site [chemical binding]; other site 164757003132 Universal stress protein family; Region: Usp; pfam00582 164757003133 Ligand Binding Site [chemical binding]; other site 164757003134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757003135 Ligand Binding Site [chemical binding]; other site 164757003136 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 164757003137 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 164757003138 active site 164757003139 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 164757003140 generic binding surface II; other site 164757003141 generic binding surface I; other site 164757003142 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 164757003143 FMN binding site [chemical binding]; other site 164757003144 dimer interface [polypeptide binding]; other site 164757003145 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 164757003146 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 164757003147 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757003148 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757003149 active site 164757003150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757003151 S-adenosylmethionine binding site [chemical binding]; other site 164757003152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757003154 ATP binding site [chemical binding]; other site 164757003155 Mg2+ binding site [ion binding]; other site 164757003156 G-X-G motif; other site 164757003157 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 164757003158 Protein of unknown function (DUF742); Region: DUF742; pfam05331 164757003159 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 164757003160 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 164757003161 G1 box; other site 164757003162 GTP/Mg2+ binding site [chemical binding]; other site 164757003163 G2 box; other site 164757003164 Switch I region; other site 164757003165 G3 box; other site 164757003166 Switch II region; other site 164757003167 G4 box; other site 164757003168 G5 box; other site 164757003169 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 164757003170 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 164757003171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 164757003172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 164757003173 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 164757003174 Transglutaminase/protease-like homologues; Region: TGc; smart00460 164757003175 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757003176 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757003177 phosphopeptide binding site; other site 164757003178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757003179 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757003180 phosphopeptide binding site; other site 164757003181 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 164757003182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 164757003183 Walker A/P-loop; other site 164757003184 ATP binding site [chemical binding]; other site 164757003185 Q-loop/lid; other site 164757003186 ABC transporter signature motif; other site 164757003187 Walker B; other site 164757003188 D-loop; other site 164757003189 H-loop/switch region; other site 164757003190 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 164757003191 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 164757003192 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 164757003193 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 164757003194 active site 164757003195 FMN binding site [chemical binding]; other site 164757003196 substrate binding site [chemical binding]; other site 164757003197 putative catalytic residue [active] 164757003198 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 164757003199 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 164757003200 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 164757003201 homodimer interface [polypeptide binding]; other site 164757003202 NADP binding site [chemical binding]; other site 164757003203 substrate binding site [chemical binding]; other site 164757003204 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 164757003205 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757003207 S-adenosylmethionine binding site [chemical binding]; other site 164757003208 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 164757003209 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 164757003210 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 164757003211 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 164757003212 homodimer interface [polypeptide binding]; other site 164757003213 substrate-cofactor binding pocket; other site 164757003214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757003215 catalytic residue [active] 164757003216 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 164757003217 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 164757003218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757003219 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 164757003220 putative catalytic site [active] 164757003221 putative metal binding site [ion binding]; other site 164757003222 putative phosphate binding site [ion binding]; other site 164757003223 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 164757003224 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 164757003225 active site 164757003226 HIGH motif; other site 164757003227 dimer interface [polypeptide binding]; other site 164757003228 KMSKS motif; other site 164757003229 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 164757003230 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 164757003231 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757003232 FMN binding site [chemical binding]; other site 164757003233 substrate binding site [chemical binding]; other site 164757003234 putative catalytic residue [active] 164757003235 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 164757003236 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 164757003237 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 164757003238 Strictosidine synthase; Region: Str_synth; pfam03088 164757003239 hypothetical protein; Provisional; Region: PRK06541 164757003240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757003241 inhibitor-cofactor binding pocket; inhibition site 164757003242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757003243 catalytic residue [active] 164757003244 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 164757003245 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 164757003246 putative DNA binding site [nucleotide binding]; other site 164757003247 putative Zn2+ binding site [ion binding]; other site 164757003248 AsnC family; Region: AsnC_trans_reg; pfam01037 164757003249 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 164757003250 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757003251 NAD(P) binding site [chemical binding]; other site 164757003252 catalytic residues [active] 164757003253 Acyltransferase family; Region: Acyl_transf_3; pfam01757 164757003254 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 164757003255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757003256 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 164757003257 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757003258 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 164757003259 Domain of unknown function DUF20; Region: UPF0118; pfam01594 164757003260 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 164757003261 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 164757003262 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 164757003263 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 164757003264 L-aspartate oxidase; Provisional; Region: PRK06175 164757003265 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757003266 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 164757003267 putative Iron-sulfur protein interface [polypeptide binding]; other site 164757003268 putative proximal heme binding site [chemical binding]; other site 164757003269 putative SdhC-like subunit interface [polypeptide binding]; other site 164757003270 putative distal heme binding site [chemical binding]; other site 164757003271 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 164757003272 putative Iron-sulfur protein interface [polypeptide binding]; other site 164757003273 putative proximal heme binding site [chemical binding]; other site 164757003274 putative SdhD-like interface [polypeptide binding]; other site 164757003275 putative distal heme binding site [chemical binding]; other site 164757003276 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 164757003277 active site 164757003278 catalytic motif [active] 164757003279 Zn binding site [ion binding]; other site 164757003280 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 164757003281 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 164757003282 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 164757003283 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 164757003284 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 164757003285 adenosine deaminase; Provisional; Region: PRK09358 164757003286 active site 164757003287 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 164757003288 Double zinc ribbon; Region: DZR; pfam12773 164757003289 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 164757003290 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757003291 cyclase homology domain; Region: CHD; cd07302 164757003292 nucleotidyl binding site; other site 164757003293 metal binding site [ion binding]; metal-binding site 164757003294 dimer interface [polypeptide binding]; other site 164757003295 Predicted ATPase [General function prediction only]; Region: COG3899 164757003296 AAA ATPase domain; Region: AAA_16; pfam13191 164757003297 cyclase homology domain; Region: CHD; cd07302 164757003298 nucleotidyl binding site; other site 164757003299 metal binding site [ion binding]; metal-binding site 164757003300 dimer interface [polypeptide binding]; other site 164757003301 AAA ATPase domain; Region: AAA_16; pfam13191 164757003302 Double zinc ribbon; Region: DZR; pfam12773 164757003303 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 164757003304 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757003305 cyclase homology domain; Region: CHD; cd07302 164757003306 nucleotidyl binding site; other site 164757003307 metal binding site [ion binding]; metal-binding site 164757003308 dimer interface [polypeptide binding]; other site 164757003309 AAA ATPase domain; Region: AAA_16; pfam13191 164757003310 Predicted ATPase [General function prediction only]; Region: COG3899 164757003311 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757003312 cyclase homology domain; Region: CHD; cd07302 164757003313 nucleotidyl binding site; other site 164757003314 metal binding site [ion binding]; metal-binding site 164757003315 dimer interface [polypeptide binding]; other site 164757003316 Predicted ATPase [General function prediction only]; Region: COG3899 164757003317 AAA ATPase domain; Region: AAA_16; pfam13191 164757003318 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757003319 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757003320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757003321 active site 164757003322 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 164757003323 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 164757003324 active site 164757003325 substrate binding site [chemical binding]; other site 164757003326 metal binding site [ion binding]; metal-binding site 164757003327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757003328 MarR family; Region: MarR_2; pfam12802 164757003329 Putative ammonia monooxygenase; Region: AmoA; pfam05145 164757003330 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 164757003331 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 164757003332 purine nucleoside phosphorylase; Provisional; Region: PRK08202 164757003333 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 164757003334 amidohydrolase; Region: amidohydrolases; TIGR01891 164757003335 metal binding site [ion binding]; metal-binding site 164757003336 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 164757003337 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 164757003338 metal binding site [ion binding]; metal-binding site 164757003339 putative dimer interface [polypeptide binding]; other site 164757003340 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 164757003341 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 164757003342 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 164757003343 putative active site pocket [active] 164757003344 dimerization interface [polypeptide binding]; other site 164757003345 putative catalytic residue [active] 164757003346 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 164757003347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757003348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757003349 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 164757003350 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 164757003351 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 164757003352 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 164757003353 active site 164757003354 short chain dehydrogenase; Provisional; Region: PRK07035 164757003355 classical (c) SDRs; Region: SDR_c; cd05233 164757003356 NAD(P) binding site [chemical binding]; other site 164757003357 active site 164757003358 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757003359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757003360 substrate binding site [chemical binding]; other site 164757003361 oxyanion hole (OAH) forming residues; other site 164757003362 trimer interface [polypeptide binding]; other site 164757003363 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 164757003364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003365 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 164757003366 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 164757003367 FAD binding pocket [chemical binding]; other site 164757003368 FAD binding motif [chemical binding]; other site 164757003369 phosphate binding motif [ion binding]; other site 164757003370 beta-alpha-beta structure motif; other site 164757003371 NAD binding pocket [chemical binding]; other site 164757003372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757003373 catalytic loop [active] 164757003374 iron binding site [ion binding]; other site 164757003375 Fatty acid desaturase; Region: FA_desaturase; pfam00487 164757003376 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 164757003377 putative di-iron ligands [ion binding]; other site 164757003378 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 164757003379 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 164757003380 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 164757003381 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 164757003382 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 164757003383 [4Fe-4S] binding site [ion binding]; other site 164757003384 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757003385 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757003386 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757003387 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 164757003388 molybdopterin cofactor binding site; other site 164757003389 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 164757003390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757003391 putative substrate translocation pore; other site 164757003392 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 164757003393 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 164757003394 putative DNA binding site [nucleotide binding]; other site 164757003395 catalytic residue [active] 164757003396 putative H2TH interface [polypeptide binding]; other site 164757003397 putative catalytic residues [active] 164757003398 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 164757003399 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 164757003400 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 164757003401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757003402 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 164757003403 ATP binding site [chemical binding]; other site 164757003404 putative Mg++ binding site [ion binding]; other site 164757003405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757003406 nucleotide binding region [chemical binding]; other site 164757003407 ATP-binding site [chemical binding]; other site 164757003408 DEAD/H associated; Region: DEAD_assoc; pfam08494 164757003409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 164757003410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757003411 NAD(P) binding site [chemical binding]; other site 164757003412 active site 164757003413 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 164757003414 glycosyltransferase, MGT family; Region: MGT; TIGR01426 164757003415 active site 164757003416 TDP-binding site; other site 164757003417 acceptor substrate-binding pocket; other site 164757003418 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 164757003419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757003420 tetrameric interface [polypeptide binding]; other site 164757003421 NAD binding site [chemical binding]; other site 164757003422 catalytic residues [active] 164757003423 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 164757003424 AsnC family; Region: AsnC_trans_reg; pfam01037 164757003425 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 164757003426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757003427 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 164757003428 L-lysine aminotransferase; Provisional; Region: PRK08297 164757003429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757003430 inhibitor-cofactor binding pocket; inhibition site 164757003431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757003432 catalytic residue [active] 164757003433 Restriction endonuclease; Region: Mrr_cat; pfam04471 164757003434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757003435 short chain dehydrogenase; Provisional; Region: PRK06701 164757003436 NAD(P) binding site [chemical binding]; other site 164757003437 active site 164757003438 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 164757003439 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 164757003440 putative ADP-binding pocket [chemical binding]; other site 164757003441 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 164757003442 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 164757003443 active site 164757003444 DNA binding site [nucleotide binding] 164757003445 Int/Topo IB signature motif; other site 164757003446 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 164757003447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 164757003448 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 164757003449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757003450 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 164757003451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757003452 DNA binding residues [nucleotide binding] 164757003453 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757003454 anti sigma factor interaction site; other site 164757003455 regulatory phosphorylation site [posttranslational modification]; other site 164757003456 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 164757003457 Ligand binding site; other site 164757003458 metal-binding site 164757003459 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757003460 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757003461 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 164757003462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757003463 DNA-binding site [nucleotide binding]; DNA binding site 164757003464 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 164757003465 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 164757003466 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 164757003467 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 164757003468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757003469 motif II; other site 164757003470 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 164757003471 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 164757003472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757003473 Walker A/P-loop; other site 164757003474 ATP binding site [chemical binding]; other site 164757003475 Q-loop/lid; other site 164757003476 ABC transporter signature motif; other site 164757003477 Walker B; other site 164757003478 D-loop; other site 164757003479 H-loop/switch region; other site 164757003480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 164757003481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757003482 dimer interface [polypeptide binding]; other site 164757003483 conserved gate region; other site 164757003484 putative PBP binding loops; other site 164757003485 ABC-ATPase subunit interface; other site 164757003486 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 164757003487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757003488 dimer interface [polypeptide binding]; other site 164757003489 conserved gate region; other site 164757003490 putative PBP binding loops; other site 164757003491 ABC-ATPase subunit interface; other site 164757003492 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 164757003493 catalytic Zn binding site [ion binding]; other site 164757003494 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 164757003495 structural Zn binding site [ion binding]; other site 164757003496 tetramer interface [polypeptide binding]; other site 164757003497 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 164757003498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757003499 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 164757003500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 164757003501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757003502 carboxyltransferase (CT) interaction site; other site 164757003503 biotinylation site [posttranslational modification]; other site 164757003504 Fe-S metabolism associated domain; Region: SufE; cl00951 164757003505 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 164757003506 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 164757003507 active site residue [active] 164757003508 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 164757003509 active site residue [active] 164757003510 Maf-like protein; Region: Maf; pfam02545 164757003511 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 164757003512 active site 164757003513 dimer interface [polypeptide binding]; other site 164757003514 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 164757003515 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757003516 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757003517 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757003518 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 164757003519 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 164757003520 Bacterial sugar transferase; Region: Bac_transf; pfam02397 164757003521 Bacterial PH domain; Region: DUF304; pfam03703 164757003522 Predicted membrane protein [Function unknown]; Region: COG2246 164757003523 GtrA-like protein; Region: GtrA; pfam04138 164757003524 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 164757003525 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757003526 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 164757003527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757003528 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 164757003529 FAD binding site [chemical binding]; other site 164757003530 homotetramer interface [polypeptide binding]; other site 164757003531 substrate binding pocket [chemical binding]; other site 164757003532 catalytic base [active] 164757003533 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 164757003534 Bacterial sugar transferase; Region: Bac_transf; pfam02397 164757003535 hypothetical protein; Provisional; Region: PRK07233 164757003536 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 164757003537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757003538 active site 164757003539 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 164757003540 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 164757003541 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 164757003542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757003543 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 164757003544 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 164757003545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757003546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 164757003547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757003548 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 164757003549 putative active site [active] 164757003550 putative catalytic site [active] 164757003551 putative Zn binding site [ion binding]; other site 164757003552 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 164757003553 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 164757003554 active site 164757003555 homodimer interface [polypeptide binding]; other site 164757003556 TIGR03089 family protein; Region: TIGR03089 164757003557 Transcriptional regulator [Transcription]; Region: LytR; COG1316 164757003558 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 164757003559 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 164757003560 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 164757003561 NADP binding site [chemical binding]; other site 164757003562 active site 164757003563 putative substrate binding site [chemical binding]; other site 164757003564 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 164757003565 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 164757003566 Probable Catalytic site; other site 164757003567 metal-binding site 164757003568 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 164757003569 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 164757003570 active site 164757003571 Substrate binding site; other site 164757003572 Mg++ binding site; other site 164757003573 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 164757003574 putative trimer interface [polypeptide binding]; other site 164757003575 putative CoA binding site [chemical binding]; other site 164757003576 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 164757003577 nudix motif; other site 164757003578 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 164757003579 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 164757003580 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 164757003581 putative FMN binding site [chemical binding]; other site 164757003582 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 164757003583 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 164757003584 phosphate binding site [ion binding]; other site 164757003585 dimer interface [polypeptide binding]; other site 164757003586 Transcription factor WhiB; Region: Whib; pfam02467 164757003587 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 164757003588 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 164757003589 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 164757003590 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 164757003591 active site 164757003592 substrate binding site [chemical binding]; other site 164757003593 metal binding site [ion binding]; metal-binding site 164757003594 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 164757003595 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 164757003596 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 164757003597 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 164757003598 amino acid transporter; Region: 2A0306; TIGR00909 164757003599 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 164757003600 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 164757003601 Fatty acid desaturase; Region: FA_desaturase; pfam00487 164757003602 Di-iron ligands [ion binding]; other site 164757003603 Rubredoxin [Energy production and conversion]; Region: COG1773 164757003604 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 164757003605 iron binding site [ion binding]; other site 164757003606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003608 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 164757003609 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 164757003610 homotetramer interface [polypeptide binding]; other site 164757003611 ligand binding site [chemical binding]; other site 164757003612 catalytic site [active] 164757003613 NAD binding site [chemical binding]; other site 164757003614 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 164757003615 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 164757003616 metal binding site [ion binding]; metal-binding site 164757003617 putative dimer interface [polypeptide binding]; other site 164757003618 Secretory lipase; Region: LIP; pfam03583 164757003619 ANTAR domain; Region: ANTAR; cl04297 164757003620 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 164757003621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 164757003622 binding surface 164757003623 TPR motif; other site 164757003624 TPR repeat; Region: TPR_11; pfam13414 164757003625 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 164757003626 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 164757003627 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 164757003628 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 164757003629 TMP-binding site; other site 164757003630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757003631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757003632 active site 164757003633 phosphorylation site [posttranslational modification] 164757003634 intermolecular recognition site; other site 164757003635 dimerization interface [polypeptide binding]; other site 164757003636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757003637 DNA binding site [nucleotide binding] 164757003638 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 164757003639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757003640 dimerization interface [polypeptide binding]; other site 164757003641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757003642 dimer interface [polypeptide binding]; other site 164757003643 phosphorylation site [posttranslational modification] 164757003644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757003645 ATP binding site [chemical binding]; other site 164757003646 Mg2+ binding site [ion binding]; other site 164757003647 G-X-G motif; other site 164757003648 lipoprotein LpqB; Provisional; Region: PRK13616 164757003649 Sporulation and spore germination; Region: Germane; pfam10646 164757003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 164757003651 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 164757003652 comF family protein; Region: comF; TIGR00201 164757003653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757003654 active site 164757003655 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 164757003656 30S subunit binding site; other site 164757003657 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 164757003658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 164757003659 ATP binding site [chemical binding]; other site 164757003660 putative Mg++ binding site [ion binding]; other site 164757003661 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 164757003662 RNA12 protein; Region: RNA12; pfam10443 164757003663 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757003664 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757003665 BCCT family transporter; Region: BCCT; pfam02028 164757003666 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 164757003667 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 164757003668 FAD binding pocket [chemical binding]; other site 164757003669 FAD binding motif [chemical binding]; other site 164757003670 phosphate binding motif [ion binding]; other site 164757003671 beta-alpha-beta structure motif; other site 164757003672 NAD binding pocket [chemical binding]; other site 164757003673 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 164757003674 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757003675 catalytic loop [active] 164757003676 iron binding site [ion binding]; other site 164757003677 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 164757003678 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 164757003679 putative di-iron ligands [ion binding]; other site 164757003680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757003681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757003682 active site 164757003683 catalytic tetrad [active] 164757003684 Predicted GTPases [General function prediction only]; Region: COG1162 164757003685 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 164757003686 GTPase/Zn-binding domain interface [polypeptide binding]; other site 164757003687 GTP/Mg2+ binding site [chemical binding]; other site 164757003688 G4 box; other site 164757003689 G5 box; other site 164757003690 G1 box; other site 164757003691 Switch I region; other site 164757003692 G2 box; other site 164757003693 G3 box; other site 164757003694 Switch II region; other site 164757003695 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 164757003696 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 164757003697 hinge; other site 164757003698 active site 164757003699 Uncharacterized conserved protein [Function unknown]; Region: COG2135 164757003700 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 164757003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757003702 S-adenosylmethionine binding site [chemical binding]; other site 164757003703 short chain dehydrogenase; Provisional; Region: PRK08278 164757003704 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 164757003705 NAD(P) binding site [chemical binding]; other site 164757003706 homodimer interface [polypeptide binding]; other site 164757003707 active site 164757003708 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 164757003709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757003710 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 164757003711 dimerization interface [polypeptide binding]; other site 164757003712 substrate binding pocket [chemical binding]; other site 164757003713 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 164757003714 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757003715 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757003716 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 164757003717 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 164757003718 AAA ATPase domain; Region: AAA_16; pfam13191 164757003719 AAA domain; Region: AAA_22; pfam13401 164757003720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757003721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757003722 DNA binding residues [nucleotide binding] 164757003723 dimerization interface [polypeptide binding]; other site 164757003724 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 164757003725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757003726 catalytic loop [active] 164757003727 iron binding site [ion binding]; other site 164757003728 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 164757003729 FAD binding pocket [chemical binding]; other site 164757003730 FAD binding motif [chemical binding]; other site 164757003731 phosphate binding motif [ion binding]; other site 164757003732 beta-alpha-beta structure motif; other site 164757003733 NAD binding pocket [chemical binding]; other site 164757003734 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 164757003735 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 164757003736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757003737 NAD(P) binding site [chemical binding]; other site 164757003738 active site 164757003739 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757003740 inter-subunit interface; other site 164757003741 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 164757003742 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757003743 iron-sulfur cluster [ion binding]; other site 164757003744 [2Fe-2S] cluster binding site [ion binding]; other site 164757003745 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 164757003746 putative alpha subunit interface [polypeptide binding]; other site 164757003747 putative active site [active] 164757003748 putative substrate binding site [chemical binding]; other site 164757003749 Fe binding site [ion binding]; other site 164757003750 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 164757003751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757003752 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 164757003753 dimerization interface [polypeptide binding]; other site 164757003754 substrate binding pocket [chemical binding]; other site 164757003755 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 164757003756 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 164757003757 active site 164757003758 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 164757003759 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 164757003760 active site 164757003761 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 164757003762 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 164757003763 putative deacylase active site [active] 164757003764 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 164757003765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757003766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757003767 DNA binding residues [nucleotide binding] 164757003768 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 164757003769 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757003770 carboxyltransferase (CT) interaction site; other site 164757003771 biotinylation site [posttranslational modification]; other site 164757003772 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 164757003773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 164757003774 Histidine kinase; Region: HisKA_2; pfam07568 164757003775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757003776 ATP binding site [chemical binding]; other site 164757003777 Mg2+ binding site [ion binding]; other site 164757003778 G-X-G motif; other site 164757003779 Transcription factor WhiB; Region: Whib; pfam02467 164757003780 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 164757003781 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 164757003782 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 164757003783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757003784 Coenzyme A binding pocket [chemical binding]; other site 164757003785 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 164757003786 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 164757003787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757003788 catalytic core [active] 164757003789 AAA domain; Region: AAA_31; pfam13614 164757003790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757003791 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 164757003792 Magnesium ion binding site [ion binding]; other site 164757003793 Domain of unknown function (DUF955); Region: DUF955; cl01076 164757003794 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 164757003795 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 164757003796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757003797 active site 164757003798 DNA binding site [nucleotide binding] 164757003799 Int/Topo IB signature motif; other site 164757003800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757003801 active site 164757003802 Int/Topo IB signature motif; other site 164757003803 DNA binding site [nucleotide binding] 164757003804 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 164757003805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757003806 putative DNA binding site [nucleotide binding]; other site 164757003807 dimerization interface [polypeptide binding]; other site 164757003808 putative Zn2+ binding site [ion binding]; other site 164757003809 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 164757003810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757003811 putative metal binding site [ion binding]; other site 164757003812 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757003813 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 164757003814 Predicted membrane protein [Function unknown]; Region: COG2259 164757003815 amino acid transporter; Region: 2A0306; TIGR00909 164757003816 multicopper oxidase; Provisional; Region: PRK10965 164757003817 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 164757003818 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 164757003819 Transposase, Mutator family; Region: Transposase_mut; pfam00872 164757003820 MULE transposase domain; Region: MULE; pfam10551 164757003821 multicopper oxidase; Provisional; Region: PRK10965 164757003822 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 164757003823 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 164757003824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757003825 dimerization interface [polypeptide binding]; other site 164757003826 putative DNA binding site [nucleotide binding]; other site 164757003827 putative Zn2+ binding site [ion binding]; other site 164757003828 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 164757003829 arsenical-resistance protein; Region: acr3; TIGR00832 164757003830 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 164757003831 Low molecular weight phosphatase family; Region: LMWPc; cd00115 164757003832 active site 164757003833 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 164757003834 Low molecular weight phosphatase family; Region: LMWPc; cl00105 164757003835 active site 164757003836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 164757003837 DEAD-like helicases superfamily; Region: DEXDc; smart00487 164757003838 ATP binding site [chemical binding]; other site 164757003839 Mg++ binding site [ion binding]; other site 164757003840 motif III; other site 164757003841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757003842 nucleotide binding region [chemical binding]; other site 164757003843 ATP-binding site [chemical binding]; other site 164757003844 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 164757003845 dinuclear metal binding motif [ion binding]; other site 164757003846 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 164757003847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003849 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 164757003850 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 164757003851 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 164757003852 ATP binding site [chemical binding]; other site 164757003853 substrate interface [chemical binding]; other site 164757003854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757003855 active site residue [active] 164757003856 TIGR02569 family protein; Region: TIGR02569_actnb 164757003857 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 164757003858 active site 164757003859 DNA binding site [nucleotide binding] 164757003860 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757003861 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 164757003862 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 164757003863 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 164757003864 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 164757003865 Predicted membrane protein [Function unknown]; Region: COG4270 164757003866 Ion channel; Region: Ion_trans_2; pfam07885 164757003867 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 164757003868 TrkA-N domain; Region: TrkA_N; pfam02254 164757003869 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 164757003870 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 164757003871 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 164757003872 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 164757003873 putative NADH binding site [chemical binding]; other site 164757003874 putative active site [active] 164757003875 nudix motif; other site 164757003876 putative metal binding site [ion binding]; other site 164757003877 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 164757003878 catalytic residues [active] 164757003879 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 164757003880 Family description; Region: UvrD_C_2; pfam13538 164757003881 HRDC domain; Region: HRDC; pfam00570 164757003882 Transcription factor WhiB; Region: Whib; pfam02467 164757003883 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 164757003884 ABC1 family; Region: ABC1; pfam03109 164757003885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 164757003886 active site 164757003887 ATP binding site [chemical binding]; other site 164757003888 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 164757003889 Uncharacterized conserved protein [Function unknown]; Region: COG5282 164757003890 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 164757003891 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 164757003892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 164757003893 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 164757003894 hypothetical protein; Validated; Region: PRK00068 164757003895 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 164757003896 DNA binding site [nucleotide binding] 164757003897 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 164757003898 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 164757003899 Predicted ATPase [General function prediction only]; Region: COG3899 164757003900 AAA ATPase domain; Region: AAA_16; pfam13191 164757003901 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 164757003902 FAD binding domain; Region: FAD_binding_4; pfam01565 164757003903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757003904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757003905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 164757003906 dimerization interface [polypeptide binding]; other site 164757003907 short chain dehydrogenase; Provisional; Region: PRK06500 164757003908 classical (c) SDRs; Region: SDR_c; cd05233 164757003909 NAD(P) binding site [chemical binding]; other site 164757003910 active site 164757003911 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757003912 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757003913 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757003914 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 164757003915 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 164757003916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003918 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757003919 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757003920 putative acyl-acceptor binding pocket; other site 164757003921 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 164757003922 Transglycosylase; Region: Transgly; pfam00912 164757003923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 164757003924 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757003925 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 164757003926 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 164757003927 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757003928 Cytochrome P450; Region: p450; cl12078 164757003929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003931 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 164757003932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757003933 dimerization interface [polypeptide binding]; other site 164757003934 putative DNA binding site [nucleotide binding]; other site 164757003935 putative Zn2+ binding site [ion binding]; other site 164757003936 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 164757003937 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 164757003938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003940 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 164757003941 Predicted membrane protein [Function unknown]; Region: COG2259 164757003942 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 164757003943 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 164757003944 G1 box; other site 164757003945 putative GEF interaction site [polypeptide binding]; other site 164757003946 GTP/Mg2+ binding site [chemical binding]; other site 164757003947 Switch I region; other site 164757003948 G2 box; other site 164757003949 G3 box; other site 164757003950 Switch II region; other site 164757003951 G4 box; other site 164757003952 G5 box; other site 164757003953 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 164757003954 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 164757003955 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757003956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757003957 NAD(P) binding site [chemical binding]; other site 164757003958 active site 164757003959 enoyl-CoA hydratase; Provisional; Region: PRK08260 164757003960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757003961 substrate binding site [chemical binding]; other site 164757003962 oxyanion hole (OAH) forming residues; other site 164757003963 trimer interface [polypeptide binding]; other site 164757003964 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 164757003965 acyl-CoA synthetase; Provisional; Region: PRK13391 164757003966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757003967 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757003968 acyl-activating enzyme (AAE) consensus motif; other site 164757003969 putative AMP binding site [chemical binding]; other site 164757003970 putative active site [active] 164757003971 acyl-activating enzyme (AAE) consensus motif; other site 164757003972 putative CoA binding site [chemical binding]; other site 164757003973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757003974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757003975 active site 164757003976 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 164757003977 classical (c) SDRs; Region: SDR_c; cd05233 164757003978 NAD(P) binding site [chemical binding]; other site 164757003979 active site 164757003980 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757003981 Phosphotransferase enzyme family; Region: APH; pfam01636 164757003982 putative active site [active] 164757003983 putative substrate binding site [chemical binding]; other site 164757003984 ATP binding site [chemical binding]; other site 164757003985 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 164757003986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003990 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 164757003991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757003992 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757003993 active site 164757003994 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 164757003995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757003998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757003999 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 164757004000 active site 164757004001 catalytic site [active] 164757004002 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757004003 active site 164757004004 catalytic site [active] 164757004005 lipid-transfer protein; Provisional; Region: PRK08256 164757004006 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757004007 active site 164757004008 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757004009 classical (c) SDRs; Region: SDR_c; cd05233 164757004010 NAD(P) binding site [chemical binding]; other site 164757004011 active site 164757004012 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757004013 cyclase homology domain; Region: CHD; cd07302 164757004014 nucleotidyl binding site; other site 164757004015 metal binding site [ion binding]; metal-binding site 164757004016 dimer interface [polypeptide binding]; other site 164757004017 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757004018 hypothetical protein; Provisional; Region: PRK08244 164757004019 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 164757004020 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 164757004021 FAD binding site [chemical binding]; other site 164757004022 Methyltransferase domain; Region: Methyltransf_11; pfam08241 164757004023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004024 Dynamin family; Region: Dynamin_N; pfam00350 164757004025 YfjP GTPase; Region: YfjP; cd11383 164757004026 G1 box; other site 164757004027 Walker A/P-loop; other site 164757004028 GTP/Mg2+ binding site [chemical binding]; other site 164757004029 ATP binding site [chemical binding]; other site 164757004030 Switch I region; other site 164757004031 G2 box; other site 164757004032 Switch II region; other site 164757004033 G3 box; other site 164757004034 G4 box; other site 164757004035 G5 box; other site 164757004036 Dynamin family; Region: Dynamin_N; pfam00350 164757004037 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 164757004038 G1 box; other site 164757004039 GTP/Mg2+ binding site [chemical binding]; other site 164757004040 G2 box; other site 164757004041 Switch I region; other site 164757004042 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 164757004043 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757004044 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 164757004045 NAD(P) binding site [chemical binding]; other site 164757004046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757004047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757004048 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 164757004049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757004050 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 164757004051 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 164757004052 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757004053 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757004054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757004055 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757004056 putative active site [active] 164757004057 putative substrate binding site [chemical binding]; other site 164757004058 ATP binding site [chemical binding]; other site 164757004059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004061 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 164757004062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004063 Walker A/P-loop; other site 164757004064 ATP binding site [chemical binding]; other site 164757004065 Q-loop/lid; other site 164757004066 ABC transporter signature motif; other site 164757004067 Walker B; other site 164757004068 D-loop; other site 164757004069 H-loop/switch region; other site 164757004070 enoyl-CoA hydratase; Provisional; Region: PRK06190 164757004071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004072 substrate binding site [chemical binding]; other site 164757004073 oxyanion hole (OAH) forming residues; other site 164757004074 trimer interface [polypeptide binding]; other site 164757004075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 164757004076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757004077 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 164757004078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757004079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 164757004080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 164757004081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757004082 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 164757004083 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 164757004084 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 164757004085 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 164757004086 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 164757004087 Binuclear center (active site) [active] 164757004088 K-pathway; other site 164757004089 Putative proton exit pathway; other site 164757004090 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 164757004091 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 164757004092 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 164757004093 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 164757004094 4Fe-4S binding domain; Region: Fer4; pfam00037 164757004095 4Fe-4S binding domain; Region: Fer4; pfam00037 164757004096 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 164757004097 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 164757004098 NADH dehydrogenase subunit G; Validated; Region: PRK07860 164757004099 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757004100 catalytic loop [active] 164757004101 iron binding site [ion binding]; other site 164757004102 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 164757004103 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757004104 molybdopterin cofactor binding site; other site 164757004105 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 164757004106 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 164757004107 SLBB domain; Region: SLBB; pfam10531 164757004108 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 164757004109 NADH dehydrogenase subunit E; Validated; Region: PRK07539 164757004110 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 164757004111 putative dimer interface [polypeptide binding]; other site 164757004112 [2Fe-2S] cluster binding site [ion binding]; other site 164757004113 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 164757004114 NADH dehydrogenase subunit D; Validated; Region: PRK06075 164757004115 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 164757004116 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 164757004117 NADH dehydrogenase subunit B; Validated; Region: PRK06411 164757004118 NADH dehydrogenase subunit A; Validated; Region: PRK07928 164757004119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 164757004120 active site 164757004121 phosphorylation site [posttranslational modification] 164757004122 intermolecular recognition site; other site 164757004123 dimerization interface [polypeptide binding]; other site 164757004124 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757004125 Methyltransferase domain; Region: Methyltransf_25; pfam13649 164757004126 S-adenosylmethionine binding site [chemical binding]; other site 164757004127 Phosphotransferase enzyme family; Region: APH; pfam01636 164757004128 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757004129 putative active site [active] 164757004130 putative substrate binding site [chemical binding]; other site 164757004131 ATP binding site [chemical binding]; other site 164757004132 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004133 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757004134 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757004135 active site 164757004136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004138 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 164757004139 active site 164757004140 catalytic residues [active] 164757004141 metal binding site [ion binding]; metal-binding site 164757004142 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757004143 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757004144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757004145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757004146 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 164757004147 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 164757004148 putative hydrophobic ligand binding site [chemical binding]; other site 164757004149 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757004150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004152 active site 164757004153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004154 Putative esterase; Region: Esterase; pfam00756 164757004155 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 164757004156 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 164757004157 NADP binding site [chemical binding]; other site 164757004158 dimer interface [polypeptide binding]; other site 164757004159 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 164757004160 RibD C-terminal domain; Region: RibD_C; cl17279 164757004161 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 164757004162 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 164757004163 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 164757004164 Protein of unknown function (DUF461); Region: DUF461; pfam04314 164757004165 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 164757004166 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004168 active site 164757004169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004170 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004171 active site 164757004172 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 164757004173 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 164757004174 active site 164757004175 ferredoxin-NADP+ reductase; Region: PLN02852 164757004176 peptide chain release factor 2; Validated; Region: prfB; PRK00578 164757004177 This domain is found in peptide chain release factors; Region: PCRF; smart00937 164757004178 RF-1 domain; Region: RF-1; pfam00472 164757004179 Mechanosensitive ion channel; Region: MS_channel; pfam00924 164757004180 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 164757004181 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 164757004182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004183 Walker A/P-loop; other site 164757004184 ATP binding site [chemical binding]; other site 164757004185 Q-loop/lid; other site 164757004186 ABC transporter signature motif; other site 164757004187 Walker B; other site 164757004188 D-loop; other site 164757004189 H-loop/switch region; other site 164757004190 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 164757004191 FtsX-like permease family; Region: FtsX; pfam02687 164757004192 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 164757004193 SmpB-tmRNA interface; other site 164757004194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757004195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757004196 metal binding site [ion binding]; metal-binding site 164757004197 active site 164757004198 I-site; other site 164757004199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 164757004200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757004201 PAS fold; Region: PAS_3; pfam08447 164757004202 HTH-like domain; Region: HTH_21; pfam13276 164757004203 Integrase core domain; Region: rve; pfam00665 164757004204 Integrase core domain; Region: rve_3; pfam13683 164757004205 Transposase; Region: HTH_Tnp_1; pfam01527 164757004206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757004207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757004208 active site 164757004209 phosphorylation site [posttranslational modification] 164757004210 intermolecular recognition site; other site 164757004211 dimerization interface [polypeptide binding]; other site 164757004212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757004213 DNA binding residues [nucleotide binding] 164757004214 dimerization interface [polypeptide binding]; other site 164757004215 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757004216 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 164757004217 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757004218 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757004219 iron-sulfur cluster [ion binding]; other site 164757004220 [2Fe-2S] cluster binding site [ion binding]; other site 164757004221 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004222 beta subunit interface [polypeptide binding]; other site 164757004223 alpha subunit interface [polypeptide binding]; other site 164757004224 active site 164757004225 substrate binding site [chemical binding]; other site 164757004226 Fe binding site [ion binding]; other site 164757004227 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004228 inter-subunit interface; other site 164757004229 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 164757004230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004231 NAD(P) binding site [chemical binding]; other site 164757004232 active site 164757004233 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 164757004234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757004235 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 164757004236 Cupin domain; Region: Cupin_2; pfam07883 164757004237 Cupin domain; Region: Cupin_2; pfam07883 164757004238 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 164757004239 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757004240 putative active site [active] 164757004241 catalytic residue [active] 164757004242 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 164757004243 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 164757004244 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 164757004245 active site 164757004246 Fe binding site [ion binding]; other site 164757004247 SCP-2 sterol transfer family; Region: SCP2; pfam02036 164757004248 Class I aldolases; Region: Aldolase_Class_I; cl17187 164757004249 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757004250 catalytic residue [active] 164757004251 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004252 inter-subunit interface; other site 164757004253 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 164757004254 L-aspartate oxidase; Provisional; Region: PRK06175 164757004255 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757004256 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 164757004257 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 164757004258 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757004259 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 164757004260 NAD(P) binding site [chemical binding]; other site 164757004261 catalytic residues [active] 164757004262 putative transposase OrfB; Reviewed; Region: PHA02517 164757004263 HTH-like domain; Region: HTH_21; pfam13276 164757004264 Integrase core domain; Region: rve; pfam00665 164757004265 Integrase core domain; Region: rve_3; pfam13683 164757004266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757004267 Transposase; Region: HTH_Tnp_1; pfam01527 164757004268 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004269 inter-subunit interface; other site 164757004270 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757004271 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 164757004272 alpha subunit interaction site [polypeptide binding]; other site 164757004273 beta subunit interaction site [polypeptide binding]; other site 164757004274 iron-sulfur cluster [ion binding]; other site 164757004275 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004276 beta subunit interface [polypeptide binding]; other site 164757004277 alpha subunit interface [polypeptide binding]; other site 164757004278 active site 164757004279 substrate binding site [chemical binding]; other site 164757004280 Fe binding site [ion binding]; other site 164757004281 short chain dehydrogenase; Provisional; Region: PRK06138 164757004282 classical (c) SDRs; Region: SDR_c; cd05233 164757004283 NAD(P) binding site [chemical binding]; other site 164757004284 active site 164757004285 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757004286 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 164757004287 putative NAD(P) binding site [chemical binding]; other site 164757004288 catalytic Zn binding site [ion binding]; other site 164757004289 VPS10 domain; Region: VPS10; smart00602 164757004290 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757004291 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757004292 [2Fe-2S] cluster binding site [ion binding]; other site 164757004293 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757004294 hydrophobic ligand binding site; other site 164757004295 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757004296 SCP-2 sterol transfer family; Region: SCP2; pfam02036 164757004297 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 164757004298 active site 164757004299 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757004300 Permease; Region: Permease; pfam02405 164757004301 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757004302 Permease; Region: Permease; pfam02405 164757004303 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004304 mce related protein; Region: MCE; pfam02470 164757004305 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757004306 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004307 mce related protein; Region: MCE; pfam02470 164757004308 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757004309 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004310 mce related protein; Region: MCE; pfam02470 164757004311 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004312 mce related protein; Region: MCE; pfam02470 164757004313 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757004314 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004315 mce related protein; Region: MCE; pfam02470 164757004316 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757004317 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757004318 mce related protein; Region: MCE; pfam02470 164757004319 Epoxide hydrolase N terminus; Region: EHN; pfam06441 164757004320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757004321 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757004322 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 164757004323 NAD(P) binding site [chemical binding]; other site 164757004324 catalytic residues [active] 164757004325 catalytic residues [active] 164757004326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757004327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757004328 putative substrate translocation pore; other site 164757004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 164757004330 MarR family; Region: MarR; pfam01047 164757004331 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757004332 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 164757004333 alpha subunit interaction site [polypeptide binding]; other site 164757004334 beta subunit interaction site [polypeptide binding]; other site 164757004335 iron-sulfur cluster [ion binding]; other site 164757004336 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004337 beta subunit interface [polypeptide binding]; other site 164757004338 alpha subunit interface [polypeptide binding]; other site 164757004339 active site 164757004340 substrate binding site [chemical binding]; other site 164757004341 Fe binding site [ion binding]; other site 164757004342 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004343 inter-subunit interface; other site 164757004344 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757004345 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 164757004346 putative NAD(P) binding site [chemical binding]; other site 164757004347 catalytic Zn binding site [ion binding]; other site 164757004348 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757004349 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757004350 lipid-transfer protein; Provisional; Region: PRK07855 164757004351 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757004352 active site 164757004353 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757004354 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757004355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757004356 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757004357 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757004358 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 164757004359 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757004360 iron-sulfur cluster [ion binding]; other site 164757004361 [2Fe-2S] cluster binding site [ion binding]; other site 164757004362 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004363 beta subunit interface [polypeptide binding]; other site 164757004364 alpha subunit interface [polypeptide binding]; other site 164757004365 active site 164757004366 substrate binding site [chemical binding]; other site 164757004367 Fe binding site [ion binding]; other site 164757004368 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004369 inter-subunit interface; other site 164757004370 Cupin domain; Region: Cupin_2; pfam07883 164757004371 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 164757004372 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757004373 MarR family; Region: MarR; pfam01047 164757004374 MarR family; Region: MarR_2; cl17246 164757004375 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757004376 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757004377 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757004378 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757004379 iron-sulfur cluster [ion binding]; other site 164757004380 [2Fe-2S] cluster binding site [ion binding]; other site 164757004381 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004382 beta subunit interface [polypeptide binding]; other site 164757004383 alpha subunit interface [polypeptide binding]; other site 164757004384 active site 164757004385 substrate binding site [chemical binding]; other site 164757004386 Fe binding site [ion binding]; other site 164757004387 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004388 inter-subunit interface; other site 164757004389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 164757004390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 164757004391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 164757004392 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 164757004393 active site 164757004394 metal binding site [ion binding]; metal-binding site 164757004395 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 164757004396 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 164757004397 intersubunit interface [polypeptide binding]; other site 164757004398 active site 164757004399 Zn2+ binding site [ion binding]; other site 164757004400 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 164757004401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004402 NAD(P) binding site [chemical binding]; other site 164757004403 active site 164757004404 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 164757004405 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 164757004406 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 164757004407 active site 164757004408 Fe binding site [ion binding]; other site 164757004409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757004410 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 164757004411 alpha subunit interaction site [polypeptide binding]; other site 164757004412 beta subunit interaction site [polypeptide binding]; other site 164757004413 iron-sulfur cluster [ion binding]; other site 164757004414 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757004415 beta subunit interface [polypeptide binding]; other site 164757004416 alpha subunit interface [polypeptide binding]; other site 164757004417 active site 164757004418 substrate binding site [chemical binding]; other site 164757004419 Fe binding site [ion binding]; other site 164757004420 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757004421 inter-subunit interface; other site 164757004422 HTH-like domain; Region: HTH_21; pfam13276 164757004423 Integrase core domain; Region: rve; pfam00665 164757004424 Integrase core domain; Region: rve_3; pfam13683 164757004425 Transposase; Region: HTH_Tnp_1; pfam01527 164757004426 Transposase; Region: HTH_Tnp_1; pfam01527 164757004427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757004428 Transposase; Region: HTH_Tnp_1; pfam01527 164757004429 HTH-like domain; Region: HTH_21; pfam13276 164757004430 Integrase core domain; Region: rve; pfam00665 164757004431 Integrase core domain; Region: rve_3; pfam13683 164757004432 Integrase core domain; Region: rve; pfam00665 164757004433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 164757004434 Integrase core domain; Region: rve_3; pfam13683 164757004435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757004436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757004437 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 164757004438 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 164757004439 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 164757004440 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757004441 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 164757004442 active site 164757004443 inhibitor site; inhibition site 164757004444 dimer interface [polypeptide binding]; other site 164757004445 catalytic residue [active] 164757004446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757004447 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 164757004448 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757004449 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 164757004450 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 164757004451 active site 164757004452 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 164757004453 active site 164757004454 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 164757004455 Lyase; Region: Lyase_1; pfam00206 164757004456 tetramer interface [polypeptide binding]; other site 164757004457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757004458 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 164757004459 Coenzyme A transferase; Region: CoA_trans; cl17247 164757004460 Coenzyme A transferase; Region: CoA_trans; cl17247 164757004461 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757004462 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 164757004463 Cupin domain; Region: Cupin_2; pfam07883 164757004464 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757004465 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 164757004466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004467 NAD(P) binding site [chemical binding]; other site 164757004468 active site 164757004469 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 164757004470 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 164757004471 putative active site [active] 164757004472 catalytic triad [active] 164757004473 putative dimer interface [polypeptide binding]; other site 164757004474 Transposase domain (DUF772); Region: DUF772; pfam05598 164757004475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 164757004476 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757004477 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757004478 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757004479 G5 domain; Region: G5; pfam07501 164757004480 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757004481 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 164757004482 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 164757004483 putative NAD(P) binding site [chemical binding]; other site 164757004484 catalytic Zn binding site [ion binding]; other site 164757004485 structural Zn binding site [ion binding]; other site 164757004486 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 164757004487 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757004488 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757004489 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 164757004490 Cytochrome P450; Region: p450; cl12078 164757004491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757004492 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 164757004493 active site 164757004494 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 164757004495 putative deacylase active site [active] 164757004496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 164757004497 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 164757004498 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757004499 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004500 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757004501 active site 164757004502 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 164757004503 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004504 acyl-activating enzyme (AAE) consensus motif; other site 164757004505 AMP binding site [chemical binding]; other site 164757004506 active site 164757004507 CoA binding site [chemical binding]; other site 164757004508 acyl carrier protein; Validated; Region: PRK05883 164757004509 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 164757004510 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 164757004511 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 164757004512 camphor resistance protein CrcB; Provisional; Region: PRK14228 164757004513 camphor resistance protein CrcB; Provisional; Region: PRK14216 164757004514 phosphoglucomutase; Validated; Region: PRK07564 164757004515 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 164757004516 active site 164757004517 substrate binding site [chemical binding]; other site 164757004518 metal binding site [ion binding]; metal-binding site 164757004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757004520 putative substrate translocation pore; other site 164757004521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757004522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757004523 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757004524 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757004525 active site 164757004526 Winged helix-turn helix; Region: HTH_29; pfam13551 164757004527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 164757004528 Integrase core domain; Region: rve; pfam00665 164757004529 Integrase core domain; Region: rve_3; pfam13683 164757004530 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757004531 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 164757004532 PE-PPE domain; Region: PE-PPE; pfam08237 164757004533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757004534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757004535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757004536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757004537 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 164757004538 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 164757004539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004540 ABC transporter signature motif; other site 164757004541 Walker B; other site 164757004542 D-loop; other site 164757004543 H-loop/switch region; other site 164757004544 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 164757004545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004546 Walker A/P-loop; other site 164757004547 ATP binding site [chemical binding]; other site 164757004548 Q-loop/lid; other site 164757004549 ABC transporter signature motif; other site 164757004550 Walker B; other site 164757004551 D-loop; other site 164757004552 H-loop/switch region; other site 164757004553 Conserved TM helix; Region: TM_helix; pfam05552 164757004554 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 164757004555 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 164757004556 active site 164757004557 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 164757004558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757004559 molybdopterin cofactor binding site; other site 164757004560 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 164757004561 molybdopterin cofactor binding site; other site 164757004562 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 164757004563 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757004564 active site 164757004565 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 164757004566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004567 active site 164757004568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 164757004569 PAS domain; Region: PAS_9; pfam13426 164757004570 putative active site [active] 164757004571 heme pocket [chemical binding]; other site 164757004572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004575 putative succinate dehydrogenase; Reviewed; Region: PRK12842 164757004576 GAF domain; Region: GAF; cl17456 164757004577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757004578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757004579 metal binding site [ion binding]; metal-binding site 164757004580 active site 164757004581 I-site; other site 164757004582 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 164757004583 hypothetical protein; Provisional; Region: PRK07877 164757004584 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 164757004585 ATP binding site [chemical binding]; other site 164757004586 substrate interface [chemical binding]; other site 164757004587 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757004588 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 164757004589 putative active site [active] 164757004590 putative catalytic site [active] 164757004591 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 164757004592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757004593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004595 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757004596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757004597 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757004598 classical (c) SDRs; Region: SDR_c; cd05233 164757004599 NAD(P) binding site [chemical binding]; other site 164757004600 active site 164757004601 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004603 active site 164757004604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757004605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004606 NAD(P) binding site [chemical binding]; other site 164757004607 active site 164757004608 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 164757004609 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757004610 dimer interface [polypeptide binding]; other site 164757004611 active site 164757004612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004614 active site 164757004615 Transcriptional regulators [Transcription]; Region: GntR; COG1802 164757004616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757004617 DNA-binding site [nucleotide binding]; DNA binding site 164757004618 FCD domain; Region: FCD; pfam07729 164757004619 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757004620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004622 acyl-activating enzyme (AAE) consensus motif; other site 164757004623 acyl-activating enzyme (AAE) consensus motif; other site 164757004624 AMP binding site [chemical binding]; other site 164757004625 active site 164757004626 CoA binding site [chemical binding]; other site 164757004627 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757004628 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004630 acyl-activating enzyme (AAE) consensus motif; other site 164757004631 AMP binding site [chemical binding]; other site 164757004632 active site 164757004633 CoA binding site [chemical binding]; other site 164757004634 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757004635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004636 AMP binding site [chemical binding]; other site 164757004637 active site 164757004638 acyl-activating enzyme (AAE) consensus motif; other site 164757004639 CoA binding site [chemical binding]; other site 164757004640 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757004641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004642 substrate binding site [chemical binding]; other site 164757004643 oxyanion hole (OAH) forming residues; other site 164757004644 trimer interface [polypeptide binding]; other site 164757004645 enoyl-CoA hydratase; Provisional; Region: PRK06494 164757004646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004647 substrate binding site [chemical binding]; other site 164757004648 oxyanion hole (OAH) forming residues; other site 164757004649 trimer interface [polypeptide binding]; other site 164757004650 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757004651 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004652 substrate binding site [chemical binding]; other site 164757004653 oxyanion hole (OAH) forming residues; other site 164757004654 trimer interface [polypeptide binding]; other site 164757004655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004656 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 164757004657 substrate binding site [chemical binding]; other site 164757004658 oxyanion hole (OAH) forming residues; other site 164757004659 trimer interface [polypeptide binding]; other site 164757004660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757004661 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 164757004662 dimer interface [polypeptide binding]; other site 164757004663 active site 164757004664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004665 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 164757004666 enoyl-CoA hydratase; Provisional; Region: PRK08252 164757004667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004668 substrate binding site [chemical binding]; other site 164757004669 oxyanion hole (OAH) forming residues; other site 164757004670 trimer interface [polypeptide binding]; other site 164757004671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004672 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 164757004673 NAD(P) binding site [chemical binding]; other site 164757004674 active site 164757004675 enoyl-CoA hydratase; Provisional; Region: PRK06210 164757004676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004677 substrate binding site [chemical binding]; other site 164757004678 oxyanion hole (OAH) forming residues; other site 164757004679 trimer interface [polypeptide binding]; other site 164757004680 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757004681 acyl-CoA synthetase; Validated; Region: PRK07798 164757004682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004683 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 164757004684 acyl-activating enzyme (AAE) consensus motif; other site 164757004685 acyl-activating enzyme (AAE) consensus motif; other site 164757004686 putative AMP binding site [chemical binding]; other site 164757004687 putative active site [active] 164757004688 putative CoA binding site [chemical binding]; other site 164757004689 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 164757004690 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757004691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004692 active site 164757004693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757004694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757004695 active site 164757004696 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 164757004697 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757004698 active site 164757004699 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757004700 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757004701 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757004702 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757004703 NAD binding site [chemical binding]; other site 164757004704 catalytic residues [active] 164757004705 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757004706 Cytochrome P450; Region: p450; cl12078 164757004707 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757004708 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757004709 NAD(P) binding site [chemical binding]; other site 164757004710 catalytic residues [active] 164757004711 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757004712 Cytochrome P450; Region: p450; cl12078 164757004713 acyl-CoA synthetase; Validated; Region: PRK07798 164757004714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757004715 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 164757004716 acyl-activating enzyme (AAE) consensus motif; other site 164757004717 putative AMP binding site [chemical binding]; other site 164757004718 putative active site [active] 164757004719 putative CoA binding site [chemical binding]; other site 164757004720 Isochorismatase family; Region: Isochorismatase; pfam00857 164757004721 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 164757004722 catalytic triad [active] 164757004723 conserved cis-peptide bond; other site 164757004724 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757004725 iron-sulfur cluster [ion binding]; other site 164757004726 [2Fe-2S] cluster binding site [ion binding]; other site 164757004727 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 164757004728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004729 NAD(P) binding site [chemical binding]; other site 164757004730 active site 164757004731 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757004732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757004733 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757004734 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 164757004735 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757004736 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757004737 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757004738 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757004739 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 164757004740 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757004741 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757004742 Cytochrome P450; Region: p450; cl12078 164757004743 Protein of unknown function (DUF466); Region: DUF466; pfam04328 164757004744 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 164757004745 Carbon starvation protein CstA; Region: CstA; pfam02554 164757004746 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 164757004747 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 164757004748 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 164757004749 active site 164757004750 DNA binding site [nucleotide binding] 164757004751 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 164757004752 DNA binding site [nucleotide binding] 164757004753 Yqey-like protein; Region: YqeY; cl17540 164757004754 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 164757004755 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 164757004756 Moco binding site; other site 164757004757 metal coordination site [ion binding]; other site 164757004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004759 NAD(P) binding site [chemical binding]; other site 164757004760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757004761 active site 164757004762 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757004763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757004764 dimerization interface [polypeptide binding]; other site 164757004765 putative DNA binding site [nucleotide binding]; other site 164757004766 putative Zn2+ binding site [ion binding]; other site 164757004767 SCP-2 sterol transfer family; Region: SCP2; cl01225 164757004768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757004769 S-adenosylmethionine binding site [chemical binding]; other site 164757004770 Phosphotransferase enzyme family; Region: APH; pfam01636 164757004771 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757004772 putative active site [active] 164757004773 putative substrate binding site [chemical binding]; other site 164757004774 ATP binding site [chemical binding]; other site 164757004775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 164757004776 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 164757004777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004779 short chain dehydrogenase; Provisional; Region: PRK07832 164757004780 classical (c) SDRs; Region: SDR_c; cd05233 164757004781 NAD(P) binding site [chemical binding]; other site 164757004782 active site 164757004783 Predicted ATPase [General function prediction only]; Region: COG4637 164757004784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004785 Walker A/P-loop; other site 164757004786 ATP binding site [chemical binding]; other site 164757004787 DNA polymerase IV; Validated; Region: PRK03352 164757004788 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 164757004789 active site 164757004790 DNA binding site [nucleotide binding] 164757004791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004792 Predicted flavoprotein [General function prediction only]; Region: COG0431 164757004793 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 164757004794 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 164757004795 catalytic residues [active] 164757004796 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 164757004797 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 164757004798 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 164757004799 Class I ribonucleotide reductase; Region: RNR_I; cd01679 164757004800 active site 164757004801 dimer interface [polypeptide binding]; other site 164757004802 catalytic residues [active] 164757004803 effector binding site; other site 164757004804 R2 peptide binding site; other site 164757004805 Predicted membrane protein [Function unknown]; Region: COG3174 164757004806 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 164757004807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 164757004808 dimerization interface [polypeptide binding]; other site 164757004809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757004810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757004811 NAD(P) binding site [chemical binding]; other site 164757004812 active site 164757004813 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 164757004814 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 164757004815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 164757004816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004817 agmatinase; Region: agmatinase; TIGR01230 164757004818 Agmatinase-like family; Region: Agmatinase-like; cd09990 164757004819 active site 164757004820 oligomer interface [polypeptide binding]; other site 164757004821 Mn binding site [ion binding]; other site 164757004822 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 164757004823 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757004824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004826 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 164757004827 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 164757004828 dimer interface [polypeptide binding]; other site 164757004829 putative radical transfer pathway; other site 164757004830 diiron center [ion binding]; other site 164757004831 tyrosyl radical; other site 164757004832 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757004833 potassium efflux protein KefA; Provisional; Region: PRK11281 164757004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757004835 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757004836 putative substrate translocation pore; other site 164757004837 Putative esterase; Region: Esterase; pfam00756 164757004838 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 164757004839 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 164757004840 putative NAD(P) binding site [chemical binding]; other site 164757004841 putative substrate binding site [chemical binding]; other site 164757004842 catalytic Zn binding site [ion binding]; other site 164757004843 structural Zn binding site [ion binding]; other site 164757004844 dimer interface [polypeptide binding]; other site 164757004845 YCII-related domain; Region: YCII; cl00999 164757004846 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 164757004847 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 164757004848 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 164757004849 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 164757004850 urea carboxylase; Region: urea_carbox; TIGR02712 164757004851 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757004852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757004853 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 164757004854 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 164757004855 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 164757004856 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757004857 carboxyltransferase (CT) interaction site; other site 164757004858 biotinylation site [posttranslational modification]; other site 164757004859 allophanate hydrolase; Provisional; Region: PRK08186 164757004860 Amidase; Region: Amidase; cl11426 164757004861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757004862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757004863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 164757004864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757004865 Walker A/P-loop; other site 164757004866 ATP binding site [chemical binding]; other site 164757004867 Q-loop/lid; other site 164757004868 ABC transporter signature motif; other site 164757004869 Walker B; other site 164757004870 D-loop; other site 164757004871 H-loop/switch region; other site 164757004872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 164757004873 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 164757004874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757004875 Walker A/P-loop; other site 164757004876 ATP binding site [chemical binding]; other site 164757004877 Q-loop/lid; other site 164757004878 ABC transporter signature motif; other site 164757004879 Walker B; other site 164757004880 D-loop; other site 164757004881 H-loop/switch region; other site 164757004882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 164757004883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 164757004884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757004885 ABC-ATPase subunit interface; other site 164757004886 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 164757004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757004888 dimer interface [polypeptide binding]; other site 164757004889 conserved gate region; other site 164757004890 putative PBP binding loops; other site 164757004891 ABC-ATPase subunit interface; other site 164757004892 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 164757004893 catalytic triad [active] 164757004894 Isochorismatase family; Region: Isochorismatase; pfam00857 164757004895 conserved cis-peptide bond; other site 164757004896 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 164757004897 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 164757004898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757004899 oxidase reductase; Provisional; Region: PTZ00273 164757004900 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 164757004901 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 164757004902 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 164757004903 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 164757004904 siderophore binding site; other site 164757004905 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 164757004906 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 164757004907 D-pathway; other site 164757004908 Putative ubiquinol binding site [chemical binding]; other site 164757004909 Low-spin heme (heme b) binding site [chemical binding]; other site 164757004910 Putative water exit pathway; other site 164757004911 Binuclear center (heme o3/CuB) [ion binding]; other site 164757004912 K-pathway; other site 164757004913 Putative proton exit pathway; other site 164757004914 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 164757004915 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 164757004916 phosphoserine phosphatase SerB; Region: serB; TIGR00338 164757004917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757004918 motif II; other site 164757004919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 164757004920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757004921 DNA-binding site [nucleotide binding]; DNA binding site 164757004922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757004923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757004924 homodimer interface [polypeptide binding]; other site 164757004925 catalytic residue [active] 164757004926 Predicted membrane protein [Function unknown]; Region: COG2364 164757004927 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 164757004928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757004929 Walker A/P-loop; other site 164757004930 ATP binding site [chemical binding]; other site 164757004931 Q-loop/lid; other site 164757004932 ABC transporter signature motif; other site 164757004933 Walker B; other site 164757004934 D-loop; other site 164757004935 H-loop/switch region; other site 164757004936 NUDIX domain; Region: NUDIX; pfam00293 164757004937 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757004938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757004939 substrate binding site [chemical binding]; other site 164757004940 oxyanion hole (OAH) forming residues; other site 164757004941 trimer interface [polypeptide binding]; other site 164757004942 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 164757004943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757004944 S-adenosylmethionine binding site [chemical binding]; other site 164757004945 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 164757004946 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 164757004947 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 164757004948 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 164757004949 FOG: WD40-like repeat [Function unknown]; Region: COG1520 164757004950 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 164757004951 active site 164757004952 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 164757004953 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 164757004954 trimer interface [polypeptide binding]; other site 164757004955 active site 164757004956 substrate binding site [chemical binding]; other site 164757004957 CoA binding site [chemical binding]; other site 164757004958 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757004959 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757004960 active site 164757004961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757004962 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757004963 Uncharacterized conserved protein [Function unknown]; Region: COG1543 164757004964 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 164757004965 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 164757004966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757004967 S-adenosylmethionine binding site [chemical binding]; other site 164757004968 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 164757004969 Ligand binding site [chemical binding]; other site 164757004970 Electron transfer flavoprotein domain; Region: ETF; pfam01012 164757004971 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 164757004972 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 164757004973 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 164757004974 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757004975 classical (c) SDRs; Region: SDR_c; cd05233 164757004976 NAD(P) binding site [chemical binding]; other site 164757004977 active site 164757004978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 164757004979 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757004980 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 164757004981 putative acyl-acceptor binding pocket; other site 164757004982 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 164757004983 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 164757004984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757004985 catalytic residue [active] 164757004986 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 164757004987 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 164757004988 Ligand Binding Site [chemical binding]; other site 164757004989 PknH-like extracellular domain; Region: PknH_C; pfam14032 164757004990 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 164757004991 4-coumarate--CoA ligase; Region: PLN02246 164757004992 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 164757004993 acyl-activating enzyme (AAE) consensus motif; other site 164757004994 active site 164757004995 putative CoA binding site [chemical binding]; other site 164757004996 AMP binding site [chemical binding]; other site 164757004997 Protein of unknown function (DUF419); Region: DUF419; pfam04237 164757004998 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 164757004999 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 164757005000 nucleotide binding pocket [chemical binding]; other site 164757005001 K-X-D-G motif; other site 164757005002 catalytic site [active] 164757005003 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 164757005004 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 164757005005 Helix-hairpin-helix motif; Region: HHH; pfam00633 164757005006 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 164757005007 Dimer interface [polypeptide binding]; other site 164757005008 BRCT sequence motif; other site 164757005009 spermidine synthase; Provisional; Region: PRK03612 164757005010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757005011 S-adenosylmethionine binding site [chemical binding]; other site 164757005012 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 164757005013 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 164757005014 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 164757005015 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 164757005016 Hemerythrin-like domain; Region: Hr-like; cd12108 164757005017 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 164757005018 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 164757005019 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 164757005020 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 164757005021 6-phosphofructokinase; Provisional; Region: PRK03202 164757005022 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 164757005023 active site 164757005024 ADP/pyrophosphate binding site [chemical binding]; other site 164757005025 dimerization interface [polypeptide binding]; other site 164757005026 allosteric effector site; other site 164757005027 fructose-1,6-bisphosphate binding site; other site 164757005028 Cutinase; Region: Cutinase; pfam01083 164757005029 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 164757005030 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 164757005031 GatB domain; Region: GatB_Yqey; pfam02637 164757005032 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 164757005033 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757005034 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757005035 enoyl-CoA hydratase; Provisional; Region: PRK06495 164757005036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757005037 substrate binding site [chemical binding]; other site 164757005038 oxyanion hole (OAH) forming residues; other site 164757005039 trimer interface [polypeptide binding]; other site 164757005040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757005041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757005042 active site 164757005043 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757005044 Phosphotransferase enzyme family; Region: APH; pfam01636 164757005045 putative active site [active] 164757005046 putative substrate binding site [chemical binding]; other site 164757005047 ATP binding site [chemical binding]; other site 164757005048 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 164757005049 classical (c) SDRs; Region: SDR_c; cd05233 164757005050 NAD(P) binding site [chemical binding]; other site 164757005051 active site 164757005052 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 164757005053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 164757005054 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 164757005055 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 164757005056 PYR/PP interface [polypeptide binding]; other site 164757005057 dimer interface [polypeptide binding]; other site 164757005058 TPP binding site [chemical binding]; other site 164757005059 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 164757005060 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 164757005061 TPP-binding site [chemical binding]; other site 164757005062 dimer interface [polypeptide binding]; other site 164757005063 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 164757005064 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 164757005065 putative valine binding site [chemical binding]; other site 164757005066 dimer interface [polypeptide binding]; other site 164757005067 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 164757005068 ketol-acid reductoisomerase; Provisional; Region: PRK05479 164757005069 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 164757005070 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 164757005071 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 164757005072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757005073 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 164757005074 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 164757005075 ligand binding site [chemical binding]; other site 164757005076 NAD binding site [chemical binding]; other site 164757005077 dimerization interface [polypeptide binding]; other site 164757005078 catalytic site [active] 164757005079 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 164757005080 putative L-serine binding site [chemical binding]; other site 164757005081 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 164757005082 tartrate dehydrogenase; Region: TTC; TIGR02089 164757005083 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 164757005084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757005085 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 164757005086 active site 164757005087 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 164757005088 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757005089 MarR family; Region: MarR_2; pfam12802 164757005090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757005091 putative substrate translocation pore; other site 164757005092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757005093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757005094 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 164757005095 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 164757005096 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 164757005097 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 164757005098 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 164757005099 active site 164757005100 HIGH motif; other site 164757005101 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 164757005102 active site 164757005103 KMSKS motif; other site 164757005104 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 164757005105 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757005106 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757005107 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 164757005108 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 164757005109 substrate binding site [chemical binding]; other site 164757005110 ligand binding site [chemical binding]; other site 164757005111 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 164757005112 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 164757005113 substrate binding site [chemical binding]; other site 164757005114 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 164757005115 IHF - DNA interface [nucleotide binding]; other site 164757005116 IHF dimer interface [polypeptide binding]; other site 164757005117 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 164757005118 active site 164757005119 Ap6A binding site [chemical binding]; other site 164757005120 nudix motif; other site 164757005121 metal binding site [ion binding]; metal-binding site 164757005122 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757005123 catalytic core [active] 164757005124 polyphosphate kinase; Provisional; Region: PRK05443 164757005125 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 164757005126 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 164757005127 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 164757005128 putative domain interface [polypeptide binding]; other site 164757005129 putative active site [active] 164757005130 catalytic site [active] 164757005131 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 164757005132 putative active site [active] 164757005133 catalytic site [active] 164757005134 Guanylyl transferase CofC like; Region: CofC; cl17472 164757005135 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 164757005136 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 164757005137 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 164757005138 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 164757005139 cystathionine gamma-lyase; Validated; Region: PRK07582 164757005140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757005141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757005142 catalytic residue [active] 164757005143 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 164757005144 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 164757005145 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757005146 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 164757005147 AsnC family; Region: AsnC_trans_reg; pfam01037 164757005148 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 164757005149 thiamine monophosphate kinase; Provisional; Region: PRK05731 164757005150 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 164757005151 ATP binding site [chemical binding]; other site 164757005152 dimerization interface [polypeptide binding]; other site 164757005153 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 164757005154 ligand binding site [chemical binding]; other site 164757005155 active site 164757005156 UGI interface [polypeptide binding]; other site 164757005157 catalytic site [active] 164757005158 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 164757005159 DAK2 domain; Region: Dak2; pfam02734 164757005160 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 164757005161 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 164757005162 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 164757005163 generic binding surface II; other site 164757005164 ssDNA binding site; other site 164757005165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757005166 ATP binding site [chemical binding]; other site 164757005167 putative Mg++ binding site [ion binding]; other site 164757005168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757005169 nucleotide binding region [chemical binding]; other site 164757005170 ATP-binding site [chemical binding]; other site 164757005171 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 164757005172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757005173 active site 164757005174 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757005175 catalytic tetrad [active] 164757005176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757005177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757005178 active site 164757005179 catalytic tetrad [active] 164757005180 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757005181 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757005182 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 164757005183 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 164757005184 catalytic residues [active] 164757005185 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 164757005186 putative active site [active] 164757005187 redox center [active] 164757005188 pyruvate carboxylase; Reviewed; Region: PRK12999 164757005189 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757005190 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757005191 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 164757005192 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 164757005193 active site 164757005194 catalytic residues [active] 164757005195 metal binding site [ion binding]; metal-binding site 164757005196 homodimer binding site [polypeptide binding]; other site 164757005197 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757005198 carboxyltransferase (CT) interaction site; other site 164757005199 biotinylation site [posttranslational modification]; other site 164757005200 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 164757005201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757005202 S-adenosylmethionine binding site [chemical binding]; other site 164757005203 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 164757005204 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 164757005205 active site 164757005206 (T/H)XGH motif; other site 164757005207 Hemerythrin-like domain; Region: Hr-like; cd12108 164757005208 Fe binding site [ion binding]; other site 164757005209 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 164757005210 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 164757005211 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 164757005212 ribonuclease III; Reviewed; Region: rnc; PRK00102 164757005213 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 164757005214 dimerization interface [polypeptide binding]; other site 164757005215 active site 164757005216 metal binding site [ion binding]; metal-binding site 164757005217 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 164757005218 dsRNA binding site [nucleotide binding]; other site 164757005219 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 164757005220 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 164757005221 DNA binding site [nucleotide binding] 164757005222 catalytic residue [active] 164757005223 H2TH interface [polypeptide binding]; other site 164757005224 putative catalytic residues [active] 164757005225 turnover-facilitating residue; other site 164757005226 intercalation triad [nucleotide binding]; other site 164757005227 8OG recognition residue [nucleotide binding]; other site 164757005228 putative reading head residues; other site 164757005229 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 164757005230 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 164757005231 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 164757005232 acylphosphatase; Provisional; Region: PRK14422 164757005233 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 164757005234 AAA domain; Region: AAA_23; pfam13476 164757005235 Walker A/P-loop; other site 164757005236 ATP binding site [chemical binding]; other site 164757005237 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 164757005238 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 164757005239 ABC transporter signature motif; other site 164757005240 Walker B; other site 164757005241 D-loop; other site 164757005242 H-loop/switch region; other site 164757005243 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 164757005244 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 164757005245 homotetramer interface [polypeptide binding]; other site 164757005246 FMN binding site [chemical binding]; other site 164757005247 homodimer contacts [polypeptide binding]; other site 164757005248 putative active site [active] 164757005249 putative substrate binding site [chemical binding]; other site 164757005250 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 164757005251 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 164757005252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757005253 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 164757005254 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 164757005255 Nitrogen regulatory protein P-II; Region: P-II; smart00938 164757005256 PII uridylyl-transferase; Provisional; Region: PRK03381 164757005257 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 164757005258 metal binding triad; other site 164757005259 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 164757005260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757005261 Zn2+ binding site [ion binding]; other site 164757005262 Mg2+ binding site [ion binding]; other site 164757005263 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 164757005264 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 164757005265 signal recognition particle protein; Provisional; Region: PRK10867 164757005266 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 164757005267 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 164757005268 P loop; other site 164757005269 GTP binding site [chemical binding]; other site 164757005270 Signal peptide binding domain; Region: SRP_SPB; pfam02978 164757005271 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 164757005272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757005273 active site 164757005274 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 164757005275 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 164757005276 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 164757005277 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 164757005278 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757005279 SnoaL-like domain; Region: SnoaL_3; pfam13474 164757005280 Methyltransferase domain; Region: Methyltransf_11; pfam08241 164757005281 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 164757005282 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 164757005283 hypothetical protein; Provisional; Region: PRK02821 164757005284 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 164757005285 G-X-X-G motif; other site 164757005286 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 164757005287 RimM N-terminal domain; Region: RimM; pfam01782 164757005288 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 164757005289 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 164757005290 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 164757005291 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 164757005292 Catalytic site [active] 164757005293 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 164757005294 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 164757005295 RNA/DNA hybrid binding site [nucleotide binding]; other site 164757005296 active site 164757005297 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 164757005298 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757005299 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757005300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757005301 UMP phosphatase; Provisional; Region: PRK10444 164757005302 active site 164757005303 motif I; other site 164757005304 motif II; other site 164757005305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757005306 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 164757005307 TPP-binding site [chemical binding]; other site 164757005308 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 164757005309 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 164757005310 PYR/PP interface [polypeptide binding]; other site 164757005311 dimer interface [polypeptide binding]; other site 164757005312 TPP binding site [chemical binding]; other site 164757005313 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 164757005314 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 164757005315 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757005316 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 164757005317 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757005318 active site 164757005319 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757005320 catalytic triad [active] 164757005321 dimer interface [polypeptide binding]; other site 164757005322 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 164757005323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757005324 active site 164757005325 CoA binding site [chemical binding]; other site 164757005326 AMP binding site [chemical binding]; other site 164757005327 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757005328 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 164757005329 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 164757005330 Walker A/P-loop; other site 164757005331 ATP binding site [chemical binding]; other site 164757005332 Q-loop/lid; other site 164757005333 ABC transporter signature motif; other site 164757005334 Walker B; other site 164757005335 D-loop; other site 164757005336 H-loop/switch region; other site 164757005337 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 164757005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757005339 dimer interface [polypeptide binding]; other site 164757005340 conserved gate region; other site 164757005341 ABC-ATPase subunit interface; other site 164757005342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757005343 dimer interface [polypeptide binding]; other site 164757005344 conserved gate region; other site 164757005345 ABC-ATPase subunit interface; other site 164757005346 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 164757005347 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 164757005348 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 164757005349 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 164757005350 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 164757005351 hypothetical protein; Reviewed; Region: PRK12497 164757005352 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 164757005353 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 164757005354 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 164757005355 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 164757005356 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 164757005357 DNA protecting protein DprA; Region: dprA; TIGR00732 164757005358 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 164757005359 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 164757005360 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 164757005361 FAD binding pocket [chemical binding]; other site 164757005362 FAD binding motif [chemical binding]; other site 164757005363 phosphate binding motif [ion binding]; other site 164757005364 NAD binding pocket [chemical binding]; other site 164757005365 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 164757005366 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 164757005367 putative active site [active] 164757005368 putative substrate binding site [chemical binding]; other site 164757005369 putative FMN binding site [chemical binding]; other site 164757005370 putative catalytic residues [active] 164757005371 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 164757005372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757005373 active site 164757005374 DNA binding site [nucleotide binding] 164757005375 Int/Topo IB signature motif; other site 164757005376 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 164757005377 Peptidase family M23; Region: Peptidase_M23; pfam01551 164757005378 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 164757005379 rRNA interaction site [nucleotide binding]; other site 164757005380 S8 interaction site; other site 164757005381 putative laminin-1 binding site; other site 164757005382 elongation factor Ts; Provisional; Region: tsf; PRK09377 164757005383 UBA/TS-N domain; Region: UBA; pfam00627 164757005384 Elongation factor TS; Region: EF_TS; pfam00889 164757005385 Elongation factor TS; Region: EF_TS; pfam00889 164757005386 amidase; Provisional; Region: PRK07869 164757005387 Amidase; Region: Amidase; cl11426 164757005388 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 164757005389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 164757005390 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 164757005391 Walker A/P-loop; other site 164757005392 ATP binding site [chemical binding]; other site 164757005393 Q-loop/lid; other site 164757005394 ABC transporter signature motif; other site 164757005395 Walker B; other site 164757005396 D-loop; other site 164757005397 H-loop/switch region; other site 164757005398 Amino acid permease; Region: AA_permease_2; pfam13520 164757005399 tyramine oxidase; Provisional; Region: tynA; PRK11504 164757005400 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 164757005401 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 164757005402 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 164757005403 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 164757005404 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 164757005405 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 164757005406 dimerization interface [polypeptide binding]; other site 164757005407 ligand binding site [chemical binding]; other site 164757005408 NADP binding site [chemical binding]; other site 164757005409 catalytic site [active] 164757005410 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 164757005411 putative nucleotide binding site [chemical binding]; other site 164757005412 uridine monophosphate binding site [chemical binding]; other site 164757005413 homohexameric interface [polypeptide binding]; other site 164757005414 ribosome recycling factor; Reviewed; Region: frr; PRK00083 164757005415 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 164757005416 hinge region; other site 164757005417 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 164757005418 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 164757005419 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 164757005420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757005421 FeS/SAM binding site; other site 164757005422 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757005423 SnoaL-like domain; Region: SnoaL_3; pfam13474 164757005424 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757005425 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757005426 NAD binding site [chemical binding]; other site 164757005427 catalytic residues [active] 164757005428 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 164757005429 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757005430 molybdopterin cofactor binding site; other site 164757005431 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 164757005432 putative molybdopterin cofactor binding site; other site 164757005433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757005434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757005435 Ecdysteroid kinase; Region: EcKinase; cl17738 164757005436 Phosphotransferase enzyme family; Region: APH; pfam01636 164757005437 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757005438 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757005439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757005440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757005441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757005442 Cytochrome P450; Region: p450; cl12078 164757005443 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757005444 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757005445 YacP-like NYN domain; Region: NYN_YacP; cl01491 164757005446 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757005447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757005448 Transposase; Region: HTH_Tnp_1; pfam01527 164757005449 HTH-like domain; Region: HTH_21; pfam13276 164757005450 Integrase core domain; Region: rve; pfam00665 164757005451 Integrase core domain; Region: rve_3; pfam13683 164757005452 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 164757005453 Strictosidine synthase; Region: Str_synth; pfam03088 164757005454 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757005455 Cytochrome P450; Region: p450; cl12078 164757005456 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757005457 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757005458 NAD(P) binding site [chemical binding]; other site 164757005459 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 164757005460 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 164757005461 classical (c) SDRs; Region: SDR_c; cd05233 164757005462 NAD(P) binding site [chemical binding]; other site 164757005463 active site 164757005464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757005465 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757005466 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757005467 putative active site [active] 164757005468 putative substrate binding site [chemical binding]; other site 164757005469 ATP binding site [chemical binding]; other site 164757005470 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757005471 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757005472 hydrophobic ligand binding site; other site 164757005473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757005474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757005475 active site 164757005476 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757005477 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757005478 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757005479 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757005480 Domain of unknown function (DUF427); Region: DUF427; cl00998 164757005481 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757005482 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757005483 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757005484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 164757005485 FAD binding domain; Region: FAD_binding_4; pfam01565 164757005486 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 164757005487 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 164757005488 DNA photolyase; Region: DNA_photolyase; pfam00875 164757005489 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 164757005490 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 164757005491 active site 164757005492 catalytic site [active] 164757005493 tetramer interface [polypeptide binding]; other site 164757005494 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 164757005495 Fasciclin domain; Region: Fasciclin; pfam02469 164757005496 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 164757005497 Fasciclin domain; Region: Fasciclin; pfam02469 164757005498 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 164757005499 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 164757005500 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 164757005501 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 164757005502 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 164757005503 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 164757005504 active site 164757005505 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 164757005506 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 164757005507 putative substrate binding region [chemical binding]; other site 164757005508 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 164757005509 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 164757005510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 164757005511 Predicted acetyltransferase [General function prediction only]; Region: COG3393 164757005512 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 164757005513 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 164757005514 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 164757005515 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 164757005516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 164757005517 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 164757005518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757005519 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757005520 CoenzymeA binding site [chemical binding]; other site 164757005521 subunit interaction site [polypeptide binding]; other site 164757005522 PHB binding site; other site 164757005523 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 164757005524 active site 164757005525 cobyric acid synthase; Provisional; Region: PRK00784 164757005526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757005527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757005528 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 164757005529 catalytic triad [active] 164757005530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757005531 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 164757005532 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757005533 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 164757005534 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 164757005535 active site 164757005536 dimer interface [polypeptide binding]; other site 164757005537 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 164757005538 Ligand Binding Site [chemical binding]; other site 164757005539 Molecular Tunnel; other site 164757005540 ethanolamine permease; Region: 2A0305; TIGR00908 164757005541 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 164757005542 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 164757005543 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757005544 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 164757005545 Peptidase C26; Region: Peptidase_C26; pfam07722 164757005546 catalytic triad [active] 164757005547 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757005548 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757005549 NAD(P) binding site [chemical binding]; other site 164757005550 catalytic residues [active] 164757005551 short chain dehydrogenase; Provisional; Region: PRK06057 164757005552 classical (c) SDRs; Region: SDR_c; cd05233 164757005553 NAD(P) binding site [chemical binding]; other site 164757005554 active site 164757005555 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757005556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757005557 DNA-binding site [nucleotide binding]; DNA binding site 164757005558 FCD domain; Region: FCD; pfam07729 164757005559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757005560 dimerization interface [polypeptide binding]; other site 164757005561 putative DNA binding site [nucleotide binding]; other site 164757005562 putative Zn2+ binding site [ion binding]; other site 164757005563 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 164757005564 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 164757005565 PDGLE domain; Region: PDGLE; pfam13190 164757005566 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 164757005567 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757005568 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 164757005569 Walker A/P-loop; other site 164757005570 ATP binding site [chemical binding]; other site 164757005571 Q-loop/lid; other site 164757005572 ABC transporter signature motif; other site 164757005573 Walker B; other site 164757005574 D-loop; other site 164757005575 H-loop/switch region; other site 164757005576 mycothione reductase; Reviewed; Region: PRK07846 164757005577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757005578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757005579 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 164757005580 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 164757005581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757005582 malate:quinone oxidoreductase; Validated; Region: PRK05257 164757005583 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 164757005584 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 164757005585 Coenzyme A binding pocket [chemical binding]; other site 164757005586 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 164757005587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757005588 Walker A motif; other site 164757005589 ATP binding site [chemical binding]; other site 164757005590 Walker B motif; other site 164757005591 arginine finger; other site 164757005592 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 164757005593 metal ion-dependent adhesion site (MIDAS); other site 164757005594 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 164757005595 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 164757005596 Walker A motif; other site 164757005597 homodimer interface [polypeptide binding]; other site 164757005598 ATP binding site [chemical binding]; other site 164757005599 hydroxycobalamin binding site [chemical binding]; other site 164757005600 Walker B motif; other site 164757005601 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 164757005602 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 164757005603 catalytic triad [active] 164757005604 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 164757005605 siroheme synthase; Provisional; Region: cysG; PRK10637 164757005606 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 164757005607 homodimer interface [polypeptide binding]; other site 164757005608 active site 164757005609 SAM binding site [chemical binding]; other site 164757005610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757005611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757005612 putative substrate translocation pore; other site 164757005613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757005614 prolyl-tRNA synthetase; Provisional; Region: PRK09194 164757005615 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 164757005616 dimer interface [polypeptide binding]; other site 164757005617 motif 1; other site 164757005618 active site 164757005619 motif 2; other site 164757005620 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 164757005621 putative deacylase active site [active] 164757005622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 164757005623 active site 164757005624 motif 3; other site 164757005625 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 164757005626 anticodon binding site; other site 164757005627 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 164757005628 dinuclear metal binding motif [ion binding]; other site 164757005629 ribosome maturation protein RimP; Reviewed; Region: PRK00092 164757005630 Sm and related proteins; Region: Sm_like; cl00259 164757005631 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 164757005632 putative oligomer interface [polypeptide binding]; other site 164757005633 putative RNA binding site [nucleotide binding]; other site 164757005634 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 164757005635 NusA N-terminal domain; Region: NusA_N; pfam08529 164757005636 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 164757005637 RNA binding site [nucleotide binding]; other site 164757005638 homodimer interface [polypeptide binding]; other site 164757005639 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 164757005640 G-X-X-G motif; other site 164757005641 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 164757005642 G-X-X-G motif; other site 164757005643 Protein of unknown function (DUF448); Region: DUF448; pfam04296 164757005644 putative RNA binding cleft [nucleotide binding]; other site 164757005645 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 164757005646 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 164757005647 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 164757005648 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 164757005649 G1 box; other site 164757005650 putative GEF interaction site [polypeptide binding]; other site 164757005651 GTP/Mg2+ binding site [chemical binding]; other site 164757005652 Switch I region; other site 164757005653 G2 box; other site 164757005654 G3 box; other site 164757005655 Switch II region; other site 164757005656 G4 box; other site 164757005657 G5 box; other site 164757005658 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 164757005659 Translation-initiation factor 2; Region: IF-2; pfam11987 164757005660 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 164757005661 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 164757005662 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 164757005663 DHH family; Region: DHH; pfam01368 164757005664 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 164757005665 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 164757005666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757005667 S-adenosylmethionine binding site [chemical binding]; other site 164757005668 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 164757005669 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757005670 DNA binding residues [nucleotide binding] 164757005671 dimer interface [polypeptide binding]; other site 164757005672 enoyl-CoA hydratase; Provisional; Region: PRK06190 164757005673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757005674 substrate binding site [chemical binding]; other site 164757005675 oxyanion hole (OAH) forming residues; other site 164757005676 trimer interface [polypeptide binding]; other site 164757005677 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 164757005678 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 164757005679 Predicted acyl esterases [General function prediction only]; Region: COG2936 164757005680 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 164757005681 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 164757005682 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 164757005683 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 164757005684 active site 164757005685 metal binding site [ion binding]; metal-binding site 164757005686 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 164757005687 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 164757005688 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 164757005689 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 164757005690 RNA binding site [nucleotide binding]; other site 164757005691 active site 164757005692 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 164757005693 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 164757005694 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 164757005695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757005696 putative DNA binding site [nucleotide binding]; other site 164757005697 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 164757005698 FeoA domain; Region: FeoA; pfam04023 164757005699 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 164757005700 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 164757005701 active site 164757005702 Riboflavin kinase; Region: Flavokinase; pfam01687 164757005703 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 164757005704 16S/18S rRNA binding site [nucleotide binding]; other site 164757005705 S13e-L30e interaction site [polypeptide binding]; other site 164757005706 25S rRNA binding site [nucleotide binding]; other site 164757005707 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 164757005708 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 164757005709 oligomer interface [polypeptide binding]; other site 164757005710 RNA binding site [nucleotide binding]; other site 164757005711 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 164757005712 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 164757005713 RNase E interface [polypeptide binding]; other site 164757005714 trimer interface [polypeptide binding]; other site 164757005715 active site 164757005716 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 164757005717 putative nucleic acid binding region [nucleotide binding]; other site 164757005718 G-X-X-G motif; other site 164757005719 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 164757005720 RNA binding site [nucleotide binding]; other site 164757005721 domain interface; other site 164757005722 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 164757005723 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 164757005724 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 164757005725 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 164757005726 hypothetical protein; Provisional; Region: PRK01842 164757005727 SEC-C motif; Region: SEC-C; pfam02810 164757005728 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 164757005729 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 164757005730 hexamer interface [polypeptide binding]; other site 164757005731 ligand binding site [chemical binding]; other site 164757005732 putative active site [active] 164757005733 NAD(P) binding site [chemical binding]; other site 164757005734 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 164757005735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757005736 putative DNA binding site [nucleotide binding]; other site 164757005737 putative Zn2+ binding site [ion binding]; other site 164757005738 AsnC family; Region: AsnC_trans_reg; pfam01037 164757005739 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757005740 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757005741 active site 164757005742 dihydrodipicolinate reductase; Provisional; Region: PRK00048 164757005743 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757005744 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 164757005745 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 164757005746 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 164757005747 Hemerythrin-like domain; Region: Hr-like; cd12108 164757005748 Fe binding site [ion binding]; other site 164757005749 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757005750 hydrophobic ligand binding site; other site 164757005751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757005752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757005753 Dienelactone hydrolase family; Region: DLH; pfam01738 164757005754 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 164757005755 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 164757005756 thymidylate synthase; Reviewed; Region: thyA; PRK01827 164757005757 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 164757005758 dimerization interface [polypeptide binding]; other site 164757005759 active site 164757005760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 164757005761 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 164757005762 folate binding site [chemical binding]; other site 164757005763 NADP+ binding site [chemical binding]; other site 164757005764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 164757005765 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 164757005766 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 164757005767 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757005768 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 164757005769 dimer interface [polypeptide binding]; other site 164757005770 active site 164757005771 catalytic residue [active] 164757005772 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 164757005773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757005774 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 164757005775 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 164757005776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757005777 NAD(P) binding site [chemical binding]; other site 164757005778 active site 164757005779 Uncharacterized conserved protein [Function unknown]; Region: COG1359 164757005780 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 164757005781 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757005782 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 164757005783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757005784 Coenzyme A binding pocket [chemical binding]; other site 164757005785 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 164757005786 Competence-damaged protein; Region: CinA; pfam02464 164757005787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757005788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757005789 non-specific DNA binding site [nucleotide binding]; other site 164757005790 salt bridge; other site 164757005791 sequence-specific DNA binding site [nucleotide binding]; other site 164757005792 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 164757005793 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757005794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 164757005795 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 164757005796 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 164757005797 dimerization interface [polypeptide binding]; other site 164757005798 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 164757005799 ATP binding site [chemical binding]; other site 164757005800 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 164757005801 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 164757005802 HupF/HypC family; Region: HupF_HypC; pfam01455 164757005803 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 164757005804 Acylphosphatase; Region: Acylphosphatase; pfam00708 164757005805 HypF finger; Region: zf-HYPF; pfam07503 164757005806 HypF finger; Region: zf-HYPF; pfam07503 164757005807 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 164757005808 HupF/HypC family; Region: HupF_HypC; pfam01455 164757005809 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 164757005810 nickel binding site [ion binding]; other site 164757005811 NifU-like domain; Region: NifU; cl00484 164757005812 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757005813 iron-sulfur cluster [ion binding]; other site 164757005814 [2Fe-2S] cluster binding site [ion binding]; other site 164757005815 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 164757005816 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 164757005817 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 164757005818 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757005819 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 164757005820 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 164757005821 recombinase A; Provisional; Region: recA; PRK09354 164757005822 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 164757005823 hexamer interface [polypeptide binding]; other site 164757005824 Walker A motif; other site 164757005825 ATP binding site [chemical binding]; other site 164757005826 Walker B motif; other site 164757005827 recombination regulator RecX; Reviewed; Region: recX; PRK00117 164757005828 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757005829 MarR family; Region: MarR_2; pfam12802 164757005830 TIGR03086 family protein; Region: TIGR03086 164757005831 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757005832 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 164757005833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757005834 dimer interface [polypeptide binding]; other site 164757005835 conserved gate region; other site 164757005836 putative PBP binding loops; other site 164757005837 ABC-ATPase subunit interface; other site 164757005838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 164757005839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757005840 dimer interface [polypeptide binding]; other site 164757005841 conserved gate region; other site 164757005842 putative PBP binding loops; other site 164757005843 ABC-ATPase subunit interface; other site 164757005844 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 164757005845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757005846 substrate binding pocket [chemical binding]; other site 164757005847 membrane-bound complex binding site; other site 164757005848 hinge residues; other site 164757005849 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757005850 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 164757005851 Walker A/P-loop; other site 164757005852 ATP binding site [chemical binding]; other site 164757005853 Q-loop/lid; other site 164757005854 ABC transporter signature motif; other site 164757005855 Walker B; other site 164757005856 D-loop; other site 164757005857 H-loop/switch region; other site 164757005858 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 164757005859 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 164757005860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757005861 FeS/SAM binding site; other site 164757005862 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 164757005863 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 164757005864 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 164757005865 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 164757005866 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 164757005867 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 164757005868 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 164757005869 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 164757005870 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 164757005871 GTPases [General function prediction only]; Region: HflX; COG2262 164757005872 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 164757005873 HflX GTPase family; Region: HflX; cd01878 164757005874 G1 box; other site 164757005875 GTP/Mg2+ binding site [chemical binding]; other site 164757005876 Switch I region; other site 164757005877 G2 box; other site 164757005878 G3 box; other site 164757005879 Switch II region; other site 164757005880 G4 box; other site 164757005881 G5 box; other site 164757005882 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 164757005883 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 164757005884 ATP binding site [chemical binding]; other site 164757005885 Mg++ binding site [ion binding]; other site 164757005886 motif III; other site 164757005887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757005888 nucleotide binding region [chemical binding]; other site 164757005889 ATP-binding site [chemical binding]; other site 164757005890 putative transposase OrfB; Reviewed; Region: PHA02517 164757005891 HTH-like domain; Region: HTH_21; pfam13276 164757005892 Integrase core domain; Region: rve; pfam00665 164757005893 Integrase core domain; Region: rve_3; pfam13683 164757005894 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 164757005895 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 164757005896 molybdopterin cofactor binding site [chemical binding]; other site 164757005897 substrate binding site [chemical binding]; other site 164757005898 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 164757005899 molybdopterin cofactor binding site; other site 164757005900 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 164757005901 LGFP repeat; Region: LGFP; pfam08310 164757005902 LGFP repeat; Region: LGFP; pfam08310 164757005903 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 164757005904 LexA repressor; Validated; Region: PRK00215 164757005905 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 164757005906 Catalytic site [active] 164757005907 LysM domain; Region: LysM; pfam01476 164757005908 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 164757005909 ATP cone domain; Region: ATP-cone; pfam03477 164757005910 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 164757005911 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757005912 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 164757005913 PAC2 family; Region: PAC2; pfam09754 164757005914 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 164757005915 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 164757005916 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 164757005917 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 164757005918 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 164757005919 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 164757005920 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 164757005921 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 164757005922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757005923 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 164757005924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757005925 DNA binding residues [nucleotide binding] 164757005926 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 164757005927 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 164757005928 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 164757005929 Protein of unknown function (DUF952); Region: DUF952; pfam06108 164757005930 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 164757005931 homotrimer interaction site [polypeptide binding]; other site 164757005932 putative active site [active] 164757005933 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 164757005934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757005935 S-adenosylmethionine binding site [chemical binding]; other site 164757005936 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 164757005937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757005938 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 164757005939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757005940 DNA binding residues [nucleotide binding] 164757005941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 164757005942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757005943 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 164757005944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 164757005945 active site 164757005946 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 164757005947 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 164757005948 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 164757005949 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 164757005950 trimer interface [polypeptide binding]; other site 164757005951 active site 164757005952 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 164757005953 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 164757005954 generic binding surface II; other site 164757005955 ssDNA binding site; other site 164757005956 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 164757005957 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 164757005958 TrkA-N domain; Region: TrkA_N; pfam02254 164757005959 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 164757005960 TrkA-N domain; Region: TrkA_N; pfam02254 164757005961 TrkA-C domain; Region: TrkA_C; pfam02080 164757005962 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757005963 TRAM domain; Region: TRAM; pfam01938 164757005964 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 164757005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757005966 MarR family; Region: MarR_2; pfam12802 164757005967 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 164757005968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 164757005969 Walker A/P-loop; other site 164757005970 ATP binding site [chemical binding]; other site 164757005971 Q-loop/lid; other site 164757005972 ABC transporter signature motif; other site 164757005973 Walker B; other site 164757005974 D-loop; other site 164757005975 H-loop/switch region; other site 164757005976 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 164757005977 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 164757005978 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 164757005979 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 164757005980 Walker A/P-loop; other site 164757005981 ATP binding site [chemical binding]; other site 164757005982 Q-loop/lid; other site 164757005983 ABC transporter signature motif; other site 164757005984 Walker B; other site 164757005985 D-loop; other site 164757005986 H-loop/switch region; other site 164757005987 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 164757005988 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 164757005989 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 164757005990 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 164757005991 TPP-binding site; other site 164757005992 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 164757005993 PYR/PP interface [polypeptide binding]; other site 164757005994 dimer interface [polypeptide binding]; other site 164757005995 TPP binding site [chemical binding]; other site 164757005996 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 164757005997 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 164757005998 putative active site [active] 164757005999 putative metal binding site [ion binding]; other site 164757006000 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 164757006001 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 164757006002 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 164757006003 catalytic site [active] 164757006004 putative active site [active] 164757006005 putative substrate binding site [chemical binding]; other site 164757006006 Helicase and RNase D C-terminal; Region: HRDC; smart00341 164757006007 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 164757006008 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 164757006009 substrate binding site [chemical binding]; other site 164757006010 active site 164757006011 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 164757006012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757006013 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 164757006014 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757006015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757006016 metal binding site [ion binding]; metal-binding site 164757006017 active site 164757006018 I-site; other site 164757006019 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 164757006020 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 164757006021 SelR domain; Region: SelR; pfam01641 164757006022 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 164757006023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757006024 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757006025 hypothetical protein; Provisional; Region: PRK14059 164757006026 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 164757006027 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 164757006028 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 164757006029 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 164757006030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757006031 Coenzyme A binding pocket [chemical binding]; other site 164757006032 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 164757006033 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 164757006034 DNA binding site [nucleotide binding] 164757006035 active site 164757006036 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 164757006037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757006038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757006039 DNA binding residues [nucleotide binding] 164757006040 Clp amino terminal domain; Region: Clp_N; pfam02861 164757006041 Clp amino terminal domain; Region: Clp_N; pfam02861 164757006042 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757006043 hydrophobic ligand binding site; other site 164757006044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757006045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757006046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757006047 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 164757006048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757006049 active site 164757006050 Int/Topo IB signature motif; other site 164757006051 DNA binding site [nucleotide binding] 164757006052 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 164757006053 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 164757006054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757006055 ATP binding site [chemical binding]; other site 164757006056 putative Mg++ binding site [ion binding]; other site 164757006057 putative transposase OrfB; Reviewed; Region: PHA02517 164757006058 HTH-like domain; Region: HTH_21; pfam13276 164757006059 Integrase core domain; Region: rve; pfam00665 164757006060 Integrase core domain; Region: rve_3; pfam13683 164757006061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757006062 Transposase; Region: HTH_Tnp_1; cl17663 164757006063 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 164757006064 GIY-YIG motif/motif A; other site 164757006065 putative active site [active] 164757006066 putative metal binding site [ion binding]; other site 164757006067 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 164757006068 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 164757006069 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 164757006070 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 164757006071 HTH-like domain; Region: HTH_21; pfam13276 164757006072 Integrase core domain; Region: rve; pfam00665 164757006073 Integrase core domain; Region: rve_3; pfam13683 164757006074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757006075 Transposase; Region: HTH_Tnp_1; pfam01527 164757006076 Epoxide hydrolase N terminus; Region: EHN; pfam06441 164757006077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757006078 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757006079 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757006080 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757006081 [2Fe-2S] cluster binding site [ion binding]; other site 164757006082 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757006083 hydrophobic ligand binding site; other site 164757006084 VPS10 domain; Region: VPS10; smart00602 164757006085 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757006086 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 164757006087 putative NAD(P) binding site [chemical binding]; other site 164757006088 catalytic Zn binding site [ion binding]; other site 164757006089 short chain dehydrogenase; Provisional; Region: PRK06138 164757006090 classical (c) SDRs; Region: SDR_c; cd05233 164757006091 NAD(P) binding site [chemical binding]; other site 164757006092 active site 164757006093 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757006094 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 164757006095 alpha subunit interaction site [polypeptide binding]; other site 164757006096 beta subunit interaction site [polypeptide binding]; other site 164757006097 iron-sulfur cluster [ion binding]; other site 164757006098 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757006099 beta subunit interface [polypeptide binding]; other site 164757006100 alpha subunit interface [polypeptide binding]; other site 164757006101 active site 164757006102 substrate binding site [chemical binding]; other site 164757006103 Fe binding site [ion binding]; other site 164757006104 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757006105 inter-subunit interface; other site 164757006106 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757006107 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 164757006108 NAD(P) binding site [chemical binding]; other site 164757006109 catalytic residues [active] 164757006110 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 164757006111 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 164757006112 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 164757006113 L-aspartate oxidase; Provisional; Region: PRK06175 164757006114 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757006115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757006116 Transposase; Region: HTH_Tnp_1; pfam01527 164757006117 putative transposase OrfB; Reviewed; Region: PHA02517 164757006118 HTH-like domain; Region: HTH_21; pfam13276 164757006119 Integrase core domain; Region: rve; pfam00665 164757006120 Integrase core domain; Region: rve_3; pfam13683 164757006121 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757006122 inter-subunit interface; other site 164757006123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 164757006124 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 164757006125 DNA-binding interface [nucleotide binding]; DNA binding site 164757006126 Integrase core domain; Region: rve; pfam00665 164757006127 HTH-like domain; Region: HTH_21; pfam13276 164757006128 Integrase core domain; Region: rve; pfam00665 164757006129 Integrase core domain; Region: rve_3; pfam13683 164757006130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757006131 Transposase; Region: HTH_Tnp_1; pfam01527 164757006132 AAA ATPase domain; Region: AAA_16; pfam13191 164757006133 Methyltransferase domain; Region: Methyltransf_26; pfam13659 164757006134 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 164757006135 PLD-like domain; Region: PLDc_2; pfam13091 164757006136 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 164757006137 putative homodimer interface [polypeptide binding]; other site 164757006138 putative active site [active] 164757006139 catalytic site [active] 164757006140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757006141 ATP binding site [chemical binding]; other site 164757006142 putative Mg++ binding site [ion binding]; other site 164757006143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757006144 nucleotide binding region [chemical binding]; other site 164757006145 ATP-binding site [chemical binding]; other site 164757006146 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757006147 active site 164757006148 Int/Topo IB signature motif; other site 164757006149 DNA binding site [nucleotide binding] 164757006150 HsdM N-terminal domain; Region: HsdM_N; pfam12161 164757006151 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 164757006152 Methyltransferase domain; Region: Methyltransf_26; pfam13659 164757006153 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 164757006154 multiple promoter invertase; Provisional; Region: mpi; PRK13413 164757006155 catalytic residues [active] 164757006156 catalytic nucleophile [active] 164757006157 Presynaptic Site I dimer interface [polypeptide binding]; other site 164757006158 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 164757006159 Synaptic Flat tetramer interface [polypeptide binding]; other site 164757006160 Synaptic Site I dimer interface [polypeptide binding]; other site 164757006161 DNA binding site [nucleotide binding] 164757006162 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 164757006163 DNA-binding interface [nucleotide binding]; DNA binding site 164757006164 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 164757006165 Transposase; Region: HTH_Tnp_1; pfam01527 164757006166 HTH-like domain; Region: HTH_21; pfam13276 164757006167 Integrase core domain; Region: rve; pfam00665 164757006168 Integrase core domain; Region: rve_3; pfam13683 164757006169 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 164757006170 AAA domain; Region: AAA_25; pfam13481 164757006171 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 164757006172 ATP binding site [chemical binding]; other site 164757006173 Walker B motif; other site 164757006174 Helix-turn-helix domain; Region: HTH_17; pfam12728 164757006175 Asp23 family; Region: Asp23; pfam03780 164757006176 Asp23 family; Region: Asp23; pfam03780 164757006177 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 164757006178 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 164757006179 GAF domain; Region: GAF; pfam01590 164757006180 GAF domain; Region: GAF_2; pfam13185 164757006181 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757006182 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 164757006183 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757006184 CoenzymeA binding site [chemical binding]; other site 164757006185 subunit interaction site [polypeptide binding]; other site 164757006186 PHB binding site; other site 164757006187 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 164757006188 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 164757006189 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 164757006190 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 164757006191 active site 164757006192 dimer interface [polypeptide binding]; other site 164757006193 motif 1; other site 164757006194 motif 2; other site 164757006195 motif 3; other site 164757006196 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 164757006197 anticodon binding site; other site 164757006198 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 164757006199 nucleotide binding site/active site [active] 164757006200 HIT family signature motif; other site 164757006201 catalytic residue [active] 164757006202 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 164757006203 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 164757006204 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 164757006205 putative acyl-acceptor binding pocket; other site 164757006206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757006207 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757006208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 164757006209 nudix motif; other site 164757006210 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 164757006211 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 164757006212 active site 164757006213 multimer interface [polypeptide binding]; other site 164757006214 acyl-CoA thioesterase II; Region: tesB; TIGR00189 164757006215 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757006216 active site 164757006217 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757006218 catalytic triad [active] 164757006219 dimer interface [polypeptide binding]; other site 164757006220 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 164757006221 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 164757006222 predicted active site [active] 164757006223 catalytic triad [active] 164757006224 hypothetical protein; Validated; Region: PRK00110 164757006225 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 164757006226 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 164757006227 substrate binding pocket [chemical binding]; other site 164757006228 chain length determination region; other site 164757006229 substrate-Mg2+ binding site; other site 164757006230 catalytic residues [active] 164757006231 aspartate-rich region 1; other site 164757006232 active site lid residues [active] 164757006233 aspartate-rich region 2; other site 164757006234 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 164757006235 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 164757006236 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757006237 classical (c) SDRs; Region: SDR_c; cd05233 164757006238 NAD(P) binding site [chemical binding]; other site 164757006239 active site 164757006240 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 164757006241 classical (c) SDRs; Region: SDR_c; cd05233 164757006242 NAD(P) binding site [chemical binding]; other site 164757006243 active site 164757006244 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 164757006245 agmatinase; Region: agmatinase; TIGR01230 164757006246 oligomer interface [polypeptide binding]; other site 164757006247 putative active site [active] 164757006248 Mn binding site [ion binding]; other site 164757006249 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 164757006250 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 164757006251 active site 164757006252 catalytic site [active] 164757006253 Zn binding site [ion binding]; other site 164757006254 tetramer interface [polypeptide binding]; other site 164757006255 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757006256 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757006257 iron-sulfur cluster [ion binding]; other site 164757006258 [2Fe-2S] cluster binding site [ion binding]; other site 164757006259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757006260 hydrophobic ligand binding site; other site 164757006261 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 164757006262 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 164757006263 FMN-binding pocket [chemical binding]; other site 164757006264 flavin binding motif; other site 164757006265 phosphate binding motif [ion binding]; other site 164757006266 beta-alpha-beta structure motif; other site 164757006267 NAD binding pocket [chemical binding]; other site 164757006268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757006269 catalytic loop [active] 164757006270 iron binding site [ion binding]; other site 164757006271 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 164757006272 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757006273 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 164757006274 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 164757006275 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 164757006276 Mechanosensitive ion channel; Region: MS_channel; pfam00924 164757006277 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 164757006278 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 164757006279 active site 164757006280 putative DNA-binding cleft [nucleotide binding]; other site 164757006281 dimer interface [polypeptide binding]; other site 164757006282 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 164757006283 RuvA N terminal domain; Region: RuvA_N; pfam01330 164757006284 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 164757006285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757006286 Walker A motif; other site 164757006287 ATP binding site [chemical binding]; other site 164757006288 Walker B motif; other site 164757006289 arginine finger; other site 164757006290 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 164757006291 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 164757006292 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 164757006293 putative di-iron ligands [ion binding]; other site 164757006294 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 164757006295 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 164757006296 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 164757006297 phosphate binding motif [ion binding]; other site 164757006298 beta-alpha-beta structure motif; other site 164757006299 NAD binding pocket [chemical binding]; other site 164757006300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757006301 catalytic loop [active] 164757006302 iron binding site [ion binding]; other site 164757006303 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 164757006304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757006305 acyl-activating enzyme (AAE) consensus motif; other site 164757006306 AMP binding site [chemical binding]; other site 164757006307 active site 164757006308 CoA binding site [chemical binding]; other site 164757006309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757006310 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 164757006311 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 164757006312 putative NAD(P) binding site [chemical binding]; other site 164757006313 active site 164757006314 putative substrate binding site [chemical binding]; other site 164757006315 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 164757006316 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 164757006317 tetrameric interface [polypeptide binding]; other site 164757006318 NAD binding site [chemical binding]; other site 164757006319 catalytic residues [active] 164757006320 substrate binding site [chemical binding]; other site 164757006321 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 164757006322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757006323 inhibitor-cofactor binding pocket; inhibition site 164757006324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757006325 catalytic residue [active] 164757006326 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 164757006327 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 164757006328 Protein export membrane protein; Region: SecD_SecF; cl14618 164757006329 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 164757006330 Protein export membrane protein; Region: SecD_SecF; pfam02355 164757006331 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 164757006332 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 164757006333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757006334 active site 164757006335 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 164757006336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757006337 Zn2+ binding site [ion binding]; other site 164757006338 Mg2+ binding site [ion binding]; other site 164757006339 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 164757006340 synthetase active site [active] 164757006341 NTP binding site [chemical binding]; other site 164757006342 metal binding site [ion binding]; metal-binding site 164757006343 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 164757006344 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 164757006345 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 164757006346 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 164757006347 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 164757006348 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 164757006349 active site 164757006350 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 164757006351 active site 164757006352 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 164757006353 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 164757006354 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 164757006355 dimer interface [polypeptide binding]; other site 164757006356 motif 1; other site 164757006357 active site 164757006358 motif 2; other site 164757006359 motif 3; other site 164757006360 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 164757006361 anticodon binding site; other site 164757006362 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757006363 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 164757006364 putative NAD(P) binding site [chemical binding]; other site 164757006365 catalytic Zn binding site [ion binding]; other site 164757006366 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 164757006367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 164757006368 Walker A/P-loop; other site 164757006369 ATP binding site [chemical binding]; other site 164757006370 Q-loop/lid; other site 164757006371 ABC transporter signature motif; other site 164757006372 Walker B; other site 164757006373 D-loop; other site 164757006374 H-loop/switch region; other site 164757006375 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 164757006376 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 164757006377 Walker A/P-loop; other site 164757006378 ATP binding site [chemical binding]; other site 164757006379 Q-loop/lid; other site 164757006380 ABC transporter signature motif; other site 164757006381 Walker B; other site 164757006382 D-loop; other site 164757006383 H-loop/switch region; other site 164757006384 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 164757006385 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 164757006386 TM-ABC transporter signature motif; other site 164757006387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 164757006388 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 164757006389 TM-ABC transporter signature motif; other site 164757006390 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 164757006391 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 164757006392 putative ligand binding site [chemical binding]; other site 164757006393 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 164757006394 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 164757006395 PYR/PP interface [polypeptide binding]; other site 164757006396 dimer interface [polypeptide binding]; other site 164757006397 TPP binding site [chemical binding]; other site 164757006398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 164757006399 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 164757006400 TPP-binding site; other site 164757006401 dimer interface [polypeptide binding]; other site 164757006402 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757006403 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 164757006404 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 164757006405 DNA-binding site [nucleotide binding]; DNA binding site 164757006406 RNA-binding motif; other site 164757006407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 164757006408 Radical SAM superfamily; Region: Radical_SAM; pfam04055 164757006409 FeS/SAM binding site; other site 164757006410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757006411 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757006412 active site 164757006413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757006414 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757006415 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757006416 active site 164757006417 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757006418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757006419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757006420 acyl-CoA thioesterase II; Region: tesB; TIGR00189 164757006421 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757006422 active site 164757006423 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757006424 catalytic triad [active] 164757006425 dimer interface [polypeptide binding]; other site 164757006426 DinB superfamily; Region: DinB_2; pfam12867 164757006427 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 164757006428 Predicted metalloprotease [General function prediction only]; Region: COG2321 164757006429 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 164757006430 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 164757006431 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757006432 substrate binding pocket [chemical binding]; other site 164757006433 catalytic triad [active] 164757006434 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 164757006435 putative hydrophobic ligand binding site [chemical binding]; other site 164757006436 protein interface [polypeptide binding]; other site 164757006437 gate; other site 164757006438 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 164757006439 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 164757006440 dimer interface [polypeptide binding]; other site 164757006441 anticodon binding site; other site 164757006442 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 164757006443 homodimer interface [polypeptide binding]; other site 164757006444 motif 1; other site 164757006445 active site 164757006446 motif 2; other site 164757006447 GAD domain; Region: GAD; pfam02938 164757006448 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 164757006449 active site 164757006450 motif 3; other site 164757006451 Uncharacterized conserved protein [Function unknown]; Region: COG3349 164757006452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757006453 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 164757006454 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 164757006455 substrate binding pocket [chemical binding]; other site 164757006456 chain length determination region; other site 164757006457 substrate-Mg2+ binding site; other site 164757006458 catalytic residues [active] 164757006459 aspartate-rich region 1; other site 164757006460 active site lid residues [active] 164757006461 aspartate-rich region 2; other site 164757006462 Predicted ATPase [General function prediction only]; Region: COG3899 164757006463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757006464 Walker A motif; other site 164757006465 ATP binding site [chemical binding]; other site 164757006466 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757006467 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 164757006468 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757006469 cyclase homology domain; Region: CHD; cd07302 164757006470 nucleotidyl binding site; other site 164757006471 metal binding site [ion binding]; metal-binding site 164757006472 dimer interface [polypeptide binding]; other site 164757006473 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757006474 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 164757006475 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 164757006476 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757006477 dimer interface [polypeptide binding]; other site 164757006478 active site 164757006479 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757006480 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 164757006481 Domain of unknown function (DUF389); Region: DUF389; cl00781 164757006482 Domain of unknown function (DUF389); Region: DUF389; pfam04087 164757006483 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 164757006484 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 164757006485 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 164757006486 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 164757006487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 164757006488 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 164757006489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 164757006490 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 164757006491 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 164757006492 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 164757006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 164757006494 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 164757006495 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 164757006496 recombination factor protein RarA; Reviewed; Region: PRK13342 164757006497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757006498 Walker A motif; other site 164757006499 ATP binding site [chemical binding]; other site 164757006500 Walker B motif; other site 164757006501 arginine finger; other site 164757006502 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 164757006503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757006504 dimerization interface [polypeptide binding]; other site 164757006505 putative DNA binding site [nucleotide binding]; other site 164757006506 putative Zn2+ binding site [ion binding]; other site 164757006507 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 164757006508 putative hydrophobic ligand binding site [chemical binding]; other site 164757006509 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 164757006510 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 164757006511 malonyl-CoA binding site [chemical binding]; other site 164757006512 dimer interface [polypeptide binding]; other site 164757006513 active site 164757006514 product binding site; other site 164757006515 Phospholipid methyltransferase; Region: PEMT; cl17370 164757006516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757006517 Transposase; Region: HTH_Tnp_1; pfam01527 164757006518 putative transposase OrfB; Reviewed; Region: PHA02517 164757006519 HTH-like domain; Region: HTH_21; pfam13276 164757006520 Integrase core domain; Region: rve; pfam00665 164757006521 Integrase core domain; Region: rve_3; pfam13683 164757006522 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 164757006523 putative hydrophobic ligand binding site [chemical binding]; other site 164757006524 gas vesicle synthesis-like protein; Reviewed; Region: PRK09368 164757006525 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 164757006526 Gas vesicle protein G; Region: GvpG; pfam05120 164757006527 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 164757006528 Gas vesicle protein; Region: Gas_vesicle; pfam00741 164757006529 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 164757006530 Gas vesicle protein; Region: Gas_vesicle; pfam00741 164757006531 Gas vesicle protein K; Region: GvpK; pfam05121 164757006532 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 164757006533 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757006534 acyl-activating enzyme (AAE) consensus motif; other site 164757006535 AMP binding site [chemical binding]; other site 164757006536 active site 164757006537 CoA binding site [chemical binding]; other site 164757006538 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 164757006539 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 164757006540 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 164757006541 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 164757006542 motif 1; other site 164757006543 active site 164757006544 motif 2; other site 164757006545 motif 3; other site 164757006546 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 164757006547 DHHA1 domain; Region: DHHA1; pfam02272 164757006548 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 164757006549 YceG-like family; Region: YceG; pfam02618 164757006550 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 164757006551 dimerization interface [polypeptide binding]; other site 164757006552 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 164757006553 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 164757006554 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 164757006555 shikimate binding site; other site 164757006556 NAD(P) binding site [chemical binding]; other site 164757006557 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 164757006558 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 164757006559 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757006560 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 164757006561 NAD(P) binding site [chemical binding]; other site 164757006562 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 164757006563 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 164757006564 Tetramer interface [polypeptide binding]; other site 164757006565 active site 164757006566 FMN-binding site [chemical binding]; other site 164757006567 shikimate kinase; Reviewed; Region: aroK; PRK00131 164757006568 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 164757006569 ADP binding site [chemical binding]; other site 164757006570 magnesium binding site [ion binding]; other site 164757006571 putative shikimate binding site; other site 164757006572 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 164757006573 active site 164757006574 dimer interface [polypeptide binding]; other site 164757006575 metal binding site [ion binding]; metal-binding site 164757006576 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 164757006577 Dehydroquinase class II; Region: DHquinase_II; pfam01220 164757006578 trimer interface [polypeptide binding]; other site 164757006579 active site 164757006580 dimer interface [polypeptide binding]; other site 164757006581 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 164757006582 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 164757006583 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 164757006584 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 164757006585 active site 164757006586 elongation factor P; Validated; Region: PRK00529 164757006587 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 164757006588 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 164757006589 RNA binding site [nucleotide binding]; other site 164757006590 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 164757006591 RNA binding site [nucleotide binding]; other site 164757006592 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 164757006593 putative RNA binding site [nucleotide binding]; other site 164757006594 hypothetical protein; Provisional; Region: PRK07236 164757006595 hypothetical protein; Validated; Region: PRK05868 164757006596 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757006597 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757006598 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 164757006599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757006600 active site 164757006601 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 164757006602 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 164757006603 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 164757006604 dihydroorotase; Validated; Region: pyrC; PRK09357 164757006605 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757006606 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 164757006607 active site 164757006608 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 164757006609 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 164757006610 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 164757006611 catalytic site [active] 164757006612 subunit interface [polypeptide binding]; other site 164757006613 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 164757006614 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757006615 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757006616 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 164757006617 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757006618 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757006619 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 164757006620 IMP binding site; other site 164757006621 dimer interface [polypeptide binding]; other site 164757006622 interdomain contacts; other site 164757006623 partial ornithine binding site; other site 164757006624 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 164757006625 active site 164757006626 dimer interface [polypeptide binding]; other site 164757006627 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 164757006628 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 164757006629 catalytic site [active] 164757006630 G-X2-G-X-G-K; other site 164757006631 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 164757006632 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 164757006633 Flavoprotein; Region: Flavoprotein; pfam02441 164757006634 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 164757006635 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 164757006636 S-adenosylmethionine synthetase; Validated; Region: PRK05250 164757006637 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 164757006638 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 164757006639 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757006640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757006641 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 164757006642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757006643 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 164757006644 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 164757006645 putative NAD(P) binding site [chemical binding]; other site 164757006646 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757006647 Predicted membrane protein [Function unknown]; Region: COG3714 164757006648 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 164757006649 primosome assembly protein PriA; Provisional; Region: PRK14873 164757006650 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 164757006651 LemA family; Region: LemA; cl00742 164757006652 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 164757006653 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 164757006654 putative active site [active] 164757006655 substrate binding site [chemical binding]; other site 164757006656 putative cosubstrate binding site; other site 164757006657 catalytic site [active] 164757006658 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 164757006659 substrate binding site [chemical binding]; other site 164757006660 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 164757006661 putative RNA binding site [nucleotide binding]; other site 164757006662 16S rRNA methyltransferase B; Provisional; Region: PRK14902 164757006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757006664 S-adenosylmethionine binding site [chemical binding]; other site 164757006665 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 164757006666 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 164757006667 substrate binding site [chemical binding]; other site 164757006668 hexamer interface [polypeptide binding]; other site 164757006669 metal binding site [ion binding]; metal-binding site 164757006670 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 164757006671 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 164757006672 catalytic motif [active] 164757006673 Zn binding site [ion binding]; other site 164757006674 RibD C-terminal domain; Region: RibD_C; pfam01872 164757006675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757006676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757006677 putative substrate translocation pore; other site 164757006678 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 164757006679 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 164757006680 Lumazine binding domain; Region: Lum_binding; pfam00677 164757006681 Lumazine binding domain; Region: Lum_binding; pfam00677 164757006682 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 164757006683 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 164757006684 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 164757006685 dimerization interface [polypeptide binding]; other site 164757006686 active site 164757006687 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 164757006688 homopentamer interface [polypeptide binding]; other site 164757006689 active site 164757006690 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 164757006691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 164757006692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757006693 Coenzyme A binding pocket [chemical binding]; other site 164757006694 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 164757006695 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 164757006696 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 164757006697 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 164757006698 GIY-YIG motif/motif A; other site 164757006699 active site 164757006700 catalytic site [active] 164757006701 putative DNA binding site [nucleotide binding]; other site 164757006702 metal binding site [ion binding]; metal-binding site 164757006703 UvrB/uvrC motif; Region: UVR; pfam02151 164757006704 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 164757006705 minor groove reading motif; other site 164757006706 Helix-hairpin-helix motif; Region: HHH; pfam00633 164757006707 helix-hairpin-helix signature motif; other site 164757006708 active site 164757006709 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 164757006710 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 164757006711 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 164757006712 phosphate binding site [ion binding]; other site 164757006713 putative substrate binding pocket [chemical binding]; other site 164757006714 dimer interface [polypeptide binding]; other site 164757006715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 164757006716 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 164757006717 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 164757006718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757006719 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757006720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757006721 active site 164757006722 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757006723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757006724 substrate binding pocket [chemical binding]; other site 164757006725 membrane-bound complex binding site; other site 164757006726 hinge residues; other site 164757006727 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 164757006728 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 164757006729 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 164757006730 Phosphoglycerate kinase; Region: PGK; pfam00162 164757006731 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 164757006732 substrate binding site [chemical binding]; other site 164757006733 hinge regions; other site 164757006734 ADP binding site [chemical binding]; other site 164757006735 catalytic site [active] 164757006736 triosephosphate isomerase; Provisional; Region: PRK14567 164757006737 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 164757006738 substrate binding site [chemical binding]; other site 164757006739 dimer interface [polypeptide binding]; other site 164757006740 catalytic triad [active] 164757006741 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 164757006742 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 164757006743 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 164757006744 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 164757006745 putative active site [active] 164757006746 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 164757006747 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 164757006748 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 164757006749 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 164757006750 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 164757006751 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 164757006752 putative active site [active] 164757006753 transaldolase; Provisional; Region: PRK03903 164757006754 catalytic residue [active] 164757006755 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 164757006756 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 164757006757 TPP-binding site [chemical binding]; other site 164757006758 dimer interface [polypeptide binding]; other site 164757006759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 164757006760 PYR/PP interface [polypeptide binding]; other site 164757006761 dimer interface [polypeptide binding]; other site 164757006762 TPP binding site [chemical binding]; other site 164757006763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 164757006764 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 164757006765 UbiA prenyltransferase family; Region: UbiA; pfam01040 164757006766 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 164757006767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757006768 Walker A/P-loop; other site 164757006769 ATP binding site [chemical binding]; other site 164757006770 Q-loop/lid; other site 164757006771 ABC transporter signature motif; other site 164757006772 Walker B; other site 164757006773 D-loop; other site 164757006774 H-loop/switch region; other site 164757006775 TOBE domain; Region: TOBE_2; pfam08402 164757006776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 164757006777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757006778 dimer interface [polypeptide binding]; other site 164757006779 conserved gate region; other site 164757006780 putative PBP binding loops; other site 164757006781 ABC-ATPase subunit interface; other site 164757006782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757006783 dimer interface [polypeptide binding]; other site 164757006784 conserved gate region; other site 164757006785 putative PBP binding loops; other site 164757006786 ABC-ATPase subunit interface; other site 164757006787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 164757006788 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 164757006789 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757006790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757006791 NAD(P) binding site [chemical binding]; other site 164757006792 active site 164757006793 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 164757006794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757006795 nucleotide binding site [chemical binding]; other site 164757006796 BtpA family; Region: BtpA; cl00440 164757006797 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 164757006798 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 164757006799 active site 164757006800 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 164757006801 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 164757006802 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 164757006803 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 164757006804 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 164757006805 NADP binding site [chemical binding]; other site 164757006806 dimer interface [polypeptide binding]; other site 164757006807 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 164757006808 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 164757006809 ABC-2 type transporter; Region: ABC2_membrane; cl17235 164757006810 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 164757006811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 164757006812 Walker A/P-loop; other site 164757006813 ATP binding site [chemical binding]; other site 164757006814 Q-loop/lid; other site 164757006815 ABC transporter signature motif; other site 164757006816 Walker B; other site 164757006817 D-loop; other site 164757006818 H-loop/switch region; other site 164757006819 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 164757006820 Predicted transcriptional regulator [Transcription]; Region: COG2345 164757006821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757006822 dimerization interface [polypeptide binding]; other site 164757006823 putative DNA binding site [nucleotide binding]; other site 164757006824 putative Zn2+ binding site [ion binding]; other site 164757006825 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 164757006826 FeS assembly protein SufB; Region: sufB; TIGR01980 164757006827 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 164757006828 FeS assembly protein SufD; Region: sufD; TIGR01981 164757006829 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 164757006830 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 164757006831 Walker A/P-loop; other site 164757006832 ATP binding site [chemical binding]; other site 164757006833 Q-loop/lid; other site 164757006834 ABC transporter signature motif; other site 164757006835 Walker B; other site 164757006836 D-loop; other site 164757006837 H-loop/switch region; other site 164757006838 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 164757006839 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 164757006840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757006841 catalytic residue [active] 164757006842 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 164757006843 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 164757006844 trimerization site [polypeptide binding]; other site 164757006845 active site 164757006846 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 164757006847 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757006848 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757006849 active site 164757006850 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 164757006851 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 164757006852 catalytic residues [active] 164757006853 enoyl-CoA hydratase; Provisional; Region: PRK05864 164757006854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757006855 substrate binding site [chemical binding]; other site 164757006856 oxyanion hole (OAH) forming residues; other site 164757006857 trimer interface [polypeptide binding]; other site 164757006858 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 164757006859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757006860 Walker A/P-loop; other site 164757006861 ATP binding site [chemical binding]; other site 164757006862 Q-loop/lid; other site 164757006863 ABC transporter signature motif; other site 164757006864 Walker B; other site 164757006865 D-loop; other site 164757006866 H-loop/switch region; other site 164757006867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757006868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757006869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757006870 aconitate hydratase; Validated; Region: PRK09277 164757006871 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 164757006872 substrate binding site [chemical binding]; other site 164757006873 ligand binding site [chemical binding]; other site 164757006874 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 164757006875 substrate binding site [chemical binding]; other site 164757006876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757006877 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757006878 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757006879 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757006880 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757006881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757006882 Walker A motif; other site 164757006883 ATP binding site [chemical binding]; other site 164757006884 Walker B motif; other site 164757006885 arginine finger; other site 164757006886 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 164757006887 Protein of unknown function DUF58; Region: DUF58; pfam01882 164757006888 hypothetical protein; Provisional; Region: PRK13685 164757006889 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 164757006890 metal ion-dependent adhesion site (MIDAS); other site 164757006891 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 164757006892 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 164757006893 NAD(P) binding site [chemical binding]; other site 164757006894 homotetramer interface [polypeptide binding]; other site 164757006895 homodimer interface [polypeptide binding]; other site 164757006896 active site 164757006897 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 164757006898 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 164757006899 NAD binding site [chemical binding]; other site 164757006900 homotetramer interface [polypeptide binding]; other site 164757006901 homodimer interface [polypeptide binding]; other site 164757006902 substrate binding site [chemical binding]; other site 164757006903 active site 164757006904 ferrochelatase; Reviewed; Region: hemH; PRK00035 164757006905 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 164757006906 C-terminal domain interface [polypeptide binding]; other site 164757006907 active site 164757006908 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 164757006909 active site 164757006910 N-terminal domain interface [polypeptide binding]; other site 164757006911 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757006912 hydroxyglutarate oxidase; Provisional; Region: PRK11728 164757006913 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 164757006914 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 164757006915 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 164757006916 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 164757006917 hydroxyglutarate oxidase; Provisional; Region: PRK11728 164757006918 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757006919 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757006920 [2Fe-2S] cluster binding site [ion binding]; other site 164757006921 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 164757006922 putative alpha subunit interface [polypeptide binding]; other site 164757006923 putative active site [active] 164757006924 putative substrate binding site [chemical binding]; other site 164757006925 Fe binding site [ion binding]; other site 164757006926 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 164757006927 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757006928 tetramerization interface [polypeptide binding]; other site 164757006929 NAD(P) binding site [chemical binding]; other site 164757006930 catalytic residues [active] 164757006931 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 164757006932 choline dehydrogenase; Validated; Region: PRK02106 164757006933 lycopene cyclase; Region: lycopene_cycl; TIGR01789 164757006934 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 164757006935 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 164757006936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 164757006937 ligand binding site [chemical binding]; other site 164757006938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 164757006939 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 164757006940 metal binding triad; other site 164757006941 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 164757006942 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757006943 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757006944 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 164757006945 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757006946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757006947 active site 164757006948 Predicted transcriptional regulator [Transcription]; Region: COG2378 164757006949 WYL domain; Region: WYL; pfam13280 164757006950 Predicted transcriptional regulator [Transcription]; Region: COG2378 164757006951 WYL domain; Region: WYL; pfam13280 164757006952 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 164757006953 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 164757006954 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 164757006955 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 164757006956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757006957 ATP binding site [chemical binding]; other site 164757006958 putative Mg++ binding site [ion binding]; other site 164757006959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757006960 nucleotide binding region [chemical binding]; other site 164757006961 ATP-binding site [chemical binding]; other site 164757006962 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 164757006963 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 164757006964 5'-3' exonuclease; Region: 53EXOc; smart00475 164757006965 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 164757006966 active site 164757006967 metal binding site 1 [ion binding]; metal-binding site 164757006968 putative 5' ssDNA interaction site; other site 164757006969 metal binding site 3; metal-binding site 164757006970 metal binding site 2 [ion binding]; metal-binding site 164757006971 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 164757006972 putative DNA binding site [nucleotide binding]; other site 164757006973 putative metal binding site [ion binding]; other site 164757006974 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 164757006975 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 164757006976 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 164757006977 active site 164757006978 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757006979 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757006980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757006981 NAD(P) binding site [chemical binding]; other site 164757006982 active site 164757006983 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 164757006984 active site 164757006985 putative homodimer interface [polypeptide binding]; other site 164757006986 SAM binding site [chemical binding]; other site 164757006987 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 164757006988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757006989 S-adenosylmethionine binding site [chemical binding]; other site 164757006990 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 164757006991 active site 164757006992 SAM binding site [chemical binding]; other site 164757006993 homodimer interface [polypeptide binding]; other site 164757006994 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 164757006995 Phosphotransferase enzyme family; Region: APH; pfam01636 164757006996 Ecdysteroid kinase; Region: EcKinase; cl17738 164757006997 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 164757006998 active site 164757006999 SAM binding site [chemical binding]; other site 164757007000 homodimer interface [polypeptide binding]; other site 164757007001 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 164757007002 active site 164757007003 SAM binding site [chemical binding]; other site 164757007004 homodimer interface [polypeptide binding]; other site 164757007005 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 164757007006 Precorrin-8X methylmutase; Region: CbiC; pfam02570 164757007007 precorrin-3B synthase; Region: CobG; TIGR02435 164757007008 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757007009 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757007010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 164757007011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 164757007012 ligand binding site [chemical binding]; other site 164757007013 flexible hinge region; other site 164757007014 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 164757007015 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 164757007016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007017 ABC-ATPase subunit interface; other site 164757007018 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 164757007019 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 164757007020 Walker A/P-loop; other site 164757007021 ATP binding site [chemical binding]; other site 164757007022 Q-loop/lid; other site 164757007023 ABC transporter signature motif; other site 164757007024 Walker B; other site 164757007025 D-loop; other site 164757007026 H-loop/switch region; other site 164757007027 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 164757007028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007029 putative PBP binding loops; other site 164757007030 dimer interface [polypeptide binding]; other site 164757007031 ABC-ATPase subunit interface; other site 164757007032 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 164757007033 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 164757007034 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 164757007035 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 164757007036 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 164757007037 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 164757007038 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 164757007039 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 164757007040 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 164757007041 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 164757007042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757007043 active site 164757007044 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 164757007045 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 164757007046 putative active site [active] 164757007047 catalytic triad [active] 164757007048 putative dimer interface [polypeptide binding]; other site 164757007049 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 164757007050 Ligand binding site; other site 164757007051 Putative Catalytic site; other site 164757007052 DXD motif; other site 164757007053 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 164757007054 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 164757007055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757007056 ATP binding site [chemical binding]; other site 164757007057 putative Mg++ binding site [ion binding]; other site 164757007058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757007059 nucleotide binding region [chemical binding]; other site 164757007060 ATP-binding site [chemical binding]; other site 164757007061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757007062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757007063 DNA binding site [nucleotide binding] 164757007064 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757007065 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 164757007066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757007067 substrate binding pocket [chemical binding]; other site 164757007068 catalytic triad [active] 164757007069 Ecdysteroid kinase; Region: EcKinase; cl17738 164757007070 Phosphotransferase enzyme family; Region: APH; pfam01636 164757007071 hypothetical protein; Provisional; Region: PRK02237 164757007072 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 164757007073 RDD family; Region: RDD; pfam06271 164757007074 Predicted membrane protein [Function unknown]; Region: COG2259 164757007075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757007076 D-xylulose kinase; Region: XylB; TIGR01312 164757007077 nucleotide binding site [chemical binding]; other site 164757007078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757007079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757007080 active site 164757007081 Transcriptional regulators [Transcription]; Region: GntR; COG1802 164757007082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757007083 DNA-binding site [nucleotide binding]; DNA binding site 164757007084 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 164757007085 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 164757007086 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 164757007087 active site 164757007088 non-prolyl cis peptide bond; other site 164757007089 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757007090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757007091 active site residue [active] 164757007092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757007093 active site residue [active] 164757007094 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 164757007095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007096 dimer interface [polypeptide binding]; other site 164757007097 conserved gate region; other site 164757007098 putative PBP binding loops; other site 164757007099 ABC-ATPase subunit interface; other site 164757007100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 164757007101 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 164757007102 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 164757007103 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 164757007104 Walker A/P-loop; other site 164757007105 ATP binding site [chemical binding]; other site 164757007106 Q-loop/lid; other site 164757007107 ABC transporter signature motif; other site 164757007108 Walker B; other site 164757007109 D-loop; other site 164757007110 H-loop/switch region; other site 164757007111 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 164757007112 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 164757007113 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757007114 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 164757007115 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 164757007116 N- and C-terminal domain interface [polypeptide binding]; other site 164757007117 putative active site [active] 164757007118 MgATP binding site [chemical binding]; other site 164757007119 catalytic site [active] 164757007120 metal binding site [ion binding]; metal-binding site 164757007121 putative xylulose binding site [chemical binding]; other site 164757007122 putative homodimer interface [polypeptide binding]; other site 164757007123 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 164757007124 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757007125 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757007126 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757007127 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757007128 Cytochrome P450; Region: p450; cl12078 164757007129 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757007130 mce related protein; Region: MCE; pfam02470 164757007131 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757007132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007133 short chain dehydrogenase; Provisional; Region: PRK07791 164757007134 NAD(P) binding site [chemical binding]; other site 164757007135 active site 164757007136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757007137 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757007138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757007139 active site 164757007140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757007141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757007142 active site 164757007143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 164757007144 metal ion-dependent adhesion site (MIDAS); other site 164757007145 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757007146 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 164757007147 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 164757007148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 164757007149 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 164757007150 ligand binding site [chemical binding]; other site 164757007151 short chain dehydrogenase; Provisional; Region: PRK06179 164757007152 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757007153 NADP binding site [chemical binding]; other site 164757007154 active site 164757007155 steroid binding site; other site 164757007156 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757007157 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757007158 NAD binding site [chemical binding]; other site 164757007159 catalytic residues [active] 164757007160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757007161 Cytochrome P450; Region: p450; cl12078 164757007162 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757007163 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757007164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757007165 Transposase; Region: HTH_Tnp_1; pfam01527 164757007166 HTH-like domain; Region: HTH_21; pfam13276 164757007167 Integrase core domain; Region: rve; pfam00665 164757007168 Integrase core domain; Region: rve_3; pfam13683 164757007169 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757007170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757007171 putative acyl-acceptor binding pocket; other site 164757007172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007176 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757007177 classical (c) SDRs; Region: SDR_c; cd05233 164757007178 NAD(P) binding site [chemical binding]; other site 164757007179 active site 164757007180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007181 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 164757007182 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757007183 Cytochrome P450; Region: p450; cl12078 164757007184 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 164757007185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757007186 DNA binding residues [nucleotide binding] 164757007187 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 164757007188 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757007189 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757007190 NAD(P) binding site [chemical binding]; other site 164757007191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 164757007192 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 164757007193 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 164757007194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007195 dimer interface [polypeptide binding]; other site 164757007196 conserved gate region; other site 164757007197 putative PBP binding loops; other site 164757007198 ABC-ATPase subunit interface; other site 164757007199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 164757007200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007201 dimer interface [polypeptide binding]; other site 164757007202 conserved gate region; other site 164757007203 putative PBP binding loops; other site 164757007204 ABC-ATPase subunit interface; other site 164757007205 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 164757007206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757007207 Walker A/P-loop; other site 164757007208 ATP binding site [chemical binding]; other site 164757007209 Q-loop/lid; other site 164757007210 ABC transporter signature motif; other site 164757007211 Walker B; other site 164757007212 D-loop; other site 164757007213 H-loop/switch region; other site 164757007214 TOBE domain; Region: TOBE_2; pfam08402 164757007215 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 164757007216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757007217 Walker A/P-loop; other site 164757007218 ATP binding site [chemical binding]; other site 164757007219 Q-loop/lid; other site 164757007220 ABC transporter signature motif; other site 164757007221 Walker B; other site 164757007222 D-loop; other site 164757007223 H-loop/switch region; other site 164757007224 dihydroxyacetone kinase; Provisional; Region: PRK14479 164757007225 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 164757007226 DAK2 domain; Region: Dak2; pfam02734 164757007227 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 164757007228 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 164757007229 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 164757007230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007231 dimer interface [polypeptide binding]; other site 164757007232 conserved gate region; other site 164757007233 putative PBP binding loops; other site 164757007234 ABC-ATPase subunit interface; other site 164757007235 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 164757007236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007237 dimer interface [polypeptide binding]; other site 164757007238 conserved gate region; other site 164757007239 putative PBP binding loops; other site 164757007240 ABC-ATPase subunit interface; other site 164757007241 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 164757007242 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 164757007243 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 164757007244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757007245 Walker A/P-loop; other site 164757007246 ATP binding site [chemical binding]; other site 164757007247 Q-loop/lid; other site 164757007248 ABC transporter signature motif; other site 164757007249 Walker B; other site 164757007250 D-loop; other site 164757007251 H-loop/switch region; other site 164757007252 TOBE domain; Region: TOBE_2; pfam08402 164757007253 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757007254 hydrophobic ligand binding site; other site 164757007255 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 164757007256 TspO/MBR family; Region: TspO_MBR; pfam03073 164757007257 tartrate dehydrogenase; Provisional; Region: PRK08194 164757007258 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 164757007259 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 164757007260 tartrate dehydrogenase; Provisional; Region: PRK08194 164757007261 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 164757007262 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 164757007263 transmembrane helices; other site 164757007264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757007265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757007266 putative DNA binding site [nucleotide binding]; other site 164757007267 putative Zn2+ binding site [ion binding]; other site 164757007268 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 164757007269 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757007270 Ferredoxin [Energy production and conversion]; Region: COG1146 164757007271 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 164757007272 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757007273 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 164757007274 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 164757007275 Walker A/P-loop; other site 164757007276 ATP binding site [chemical binding]; other site 164757007277 Q-loop/lid; other site 164757007278 ABC transporter signature motif; other site 164757007279 Walker B; other site 164757007280 D-loop; other site 164757007281 H-loop/switch region; other site 164757007282 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 164757007283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007284 dimer interface [polypeptide binding]; other site 164757007285 conserved gate region; other site 164757007286 putative PBP binding loops; other site 164757007287 ABC-ATPase subunit interface; other site 164757007288 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 164757007289 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 164757007290 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 164757007291 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 164757007292 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 164757007293 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 164757007294 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 164757007295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757007296 catalytic residue [active] 164757007297 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 164757007298 YaeQ protein; Region: YaeQ; pfam07152 164757007299 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757007300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757007301 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 164757007302 Flavin binding site [chemical binding]; other site 164757007303 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 164757007304 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 164757007305 AMP-binding domain protein; Validated; Region: PRK07529 164757007306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757007307 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 164757007308 acyl-activating enzyme (AAE) consensus motif; other site 164757007309 putative AMP binding site [chemical binding]; other site 164757007310 putative active site [active] 164757007311 putative CoA binding site [chemical binding]; other site 164757007312 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757007313 CoenzymeA binding site [chemical binding]; other site 164757007314 subunit interaction site [polypeptide binding]; other site 164757007315 PHB binding site; other site 164757007316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757007317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757007318 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 164757007319 putative substrate binding pocket [chemical binding]; other site 164757007320 dimerization interface [polypeptide binding]; other site 164757007321 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 164757007322 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 164757007323 tetramer interface [polypeptide binding]; other site 164757007324 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 164757007325 tetramer interface [polypeptide binding]; other site 164757007326 active site 164757007327 metal binding site [ion binding]; metal-binding site 164757007328 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 164757007329 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 164757007330 NAD binding site [chemical binding]; other site 164757007331 catalytic residues [active] 164757007332 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757007333 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 164757007334 dimer interface [polypeptide binding]; other site 164757007335 active site 164757007336 catalytic residue [active] 164757007337 hypothetical protein; Provisional; Region: PRK12764 164757007338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 164757007339 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 164757007340 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 164757007341 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 164757007342 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 164757007343 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 164757007344 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 164757007345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757007346 active site 164757007347 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 164757007348 short chain dehydrogenase; Provisional; Region: PRK08263 164757007349 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757007350 NADP binding site [chemical binding]; other site 164757007351 active site 164757007352 steroid binding site; other site 164757007353 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 164757007354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757007355 DNA binding residues [nucleotide binding] 164757007356 putative dimer interface [polypeptide binding]; other site 164757007357 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 164757007358 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757007359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757007360 salt bridge; other site 164757007361 non-specific DNA binding site [nucleotide binding]; other site 164757007362 sequence-specific DNA binding site [nucleotide binding]; other site 164757007363 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 164757007364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007365 NAD(P) binding site [chemical binding]; other site 164757007366 active site 164757007367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007369 aldose dehydrogenase; Validated; Region: PRK06398 164757007370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007371 NAD(P) binding site [chemical binding]; other site 164757007372 active site 164757007373 choline dehydrogenase; Validated; Region: PRK02106 164757007374 lycopene cyclase; Region: lycopene_cycl; TIGR01789 164757007375 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 164757007376 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 164757007377 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757007378 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 164757007379 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757007380 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 164757007381 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 164757007382 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 164757007383 NIPSNAP; Region: NIPSNAP; pfam07978 164757007384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007386 WHG domain; Region: WHG; pfam13305 164757007387 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757007388 MarR family; Region: MarR_2; cl17246 164757007389 RibD C-terminal domain; Region: RibD_C; cl17279 164757007390 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757007391 Predicted membrane protein [Function unknown]; Region: COG2323 164757007392 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 164757007393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757007394 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 164757007395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757007396 DNA binding residues [nucleotide binding] 164757007397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757007398 MarR family; Region: MarR; pfam01047 164757007399 Protein of unknown function (DUF461); Region: DUF461; cl01071 164757007400 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 164757007401 Predicted membrane protein [Function unknown]; Region: COG4325 164757007402 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757007403 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 164757007404 dimerization interface [polypeptide binding]; other site 164757007405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007407 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757007408 classical (c) SDRs; Region: SDR_c; cd05233 164757007409 NAD(P) binding site [chemical binding]; other site 164757007410 active site 164757007411 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 164757007412 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757007413 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 164757007414 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757007415 classical (c) SDRs; Region: SDR_c; cd05233 164757007416 NAD(P) binding site [chemical binding]; other site 164757007417 active site 164757007418 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 164757007419 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 164757007420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 164757007421 AAA domain; Region: AAA_33; pfam13671 164757007422 hypothetical protein; Provisional; Region: PRK06834 164757007423 TrkA-N domain; Region: TrkA_N; pfam02254 164757007424 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757007425 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757007426 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757007427 active site 164757007428 catalytic tetrad [active] 164757007429 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 164757007430 RNA binding surface [nucleotide binding]; other site 164757007431 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757007432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757007433 substrate binding site [chemical binding]; other site 164757007434 oxyanion hole (OAH) forming residues; other site 164757007435 trimer interface [polypeptide binding]; other site 164757007436 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 164757007437 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757007438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757007439 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757007440 acyl-activating enzyme (AAE) consensus motif; other site 164757007441 acyl-activating enzyme (AAE) consensus motif; other site 164757007442 AMP binding site [chemical binding]; other site 164757007443 active site 164757007444 CoA binding site [chemical binding]; other site 164757007445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 164757007446 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 164757007447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007449 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 164757007450 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757007451 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 164757007452 Prostaglandin dehydrogenases; Region: PGDH; cd05288 164757007453 NAD(P) binding site [chemical binding]; other site 164757007454 substrate binding site [chemical binding]; other site 164757007455 dimer interface [polypeptide binding]; other site 164757007456 MOSC domain; Region: MOSC; pfam03473 164757007457 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757007458 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757007459 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757007460 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757007461 hydrophobic ligand binding site; other site 164757007462 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 164757007463 metal binding site 2 [ion binding]; metal-binding site 164757007464 putative DNA binding helix; other site 164757007465 metal binding site 1 [ion binding]; metal-binding site 164757007466 dimer interface [polypeptide binding]; other site 164757007467 structural Zn2+ binding site [ion binding]; other site 164757007468 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 164757007469 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 164757007470 heme binding site [chemical binding]; other site 164757007471 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 164757007472 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 164757007473 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 164757007474 active site 164757007475 catalytic triad [active] 164757007476 oxyanion hole [active] 164757007477 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757007478 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 164757007479 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 164757007480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757007481 active site 164757007482 phosphorylation site [posttranslational modification] 164757007483 intermolecular recognition site; other site 164757007484 dimerization interface [polypeptide binding]; other site 164757007485 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757007486 CHASE3 domain; Region: CHASE3; pfam05227 164757007487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757007488 dimerization interface [polypeptide binding]; other site 164757007489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757007490 dimer interface [polypeptide binding]; other site 164757007491 phosphorylation site [posttranslational modification] 164757007492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757007493 ATP binding site [chemical binding]; other site 164757007494 Mg2+ binding site [ion binding]; other site 164757007495 G-X-G motif; other site 164757007496 Response regulator receiver domain; Region: Response_reg; pfam00072 164757007497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757007498 active site 164757007499 phosphorylation site [posttranslational modification] 164757007500 intermolecular recognition site; other site 164757007501 dimerization interface [polypeptide binding]; other site 164757007502 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 164757007503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757007504 dimerization interface [polypeptide binding]; other site 164757007505 putative DNA binding site [nucleotide binding]; other site 164757007506 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757007507 putative Zn2+ binding site [ion binding]; other site 164757007508 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 164757007509 putative hydrophobic ligand binding site [chemical binding]; other site 164757007510 NlpC/P60 family; Region: NLPC_P60; cl17555 164757007511 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 164757007512 Uncharacterized conserved protein [Function unknown]; Region: COG3379 164757007513 hypothetical protein; Validated; Region: PRK02101 164757007514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757007515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757007516 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757007517 Helix-turn-helix domain; Region: HTH_18; pfam12833 164757007518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757007519 hypothetical protein; Provisional; Region: PRK01346 164757007520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 164757007521 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 164757007522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757007523 catalytic residue [active] 164757007524 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 164757007525 putative active site [active] 164757007526 catalytic residue [active] 164757007527 Amidase; Region: Amidase; cl11426 164757007528 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 164757007529 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757007530 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 164757007531 competence damage-inducible protein A; Provisional; Region: PRK00549 164757007532 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 164757007533 putative MPT binding site; other site 164757007534 Competence-damaged protein; Region: CinA; pfam02464 164757007535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757007536 Biofilm formation and stress response factor; Region: BsmA; pfam10014 164757007537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757007539 NAD(P) binding site [chemical binding]; other site 164757007540 active site 164757007541 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757007542 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757007543 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 164757007544 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757007545 anti sigma factor interaction site; other site 164757007546 regulatory phosphorylation site [posttranslational modification]; other site 164757007547 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 164757007548 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 164757007549 Nitronate monooxygenase; Region: NMO; pfam03060 164757007550 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757007551 FMN binding site [chemical binding]; other site 164757007552 substrate binding site [chemical binding]; other site 164757007553 putative catalytic residue [active] 164757007554 Ferredoxin [Energy production and conversion]; Region: COG1146 164757007555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007557 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 164757007558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757007559 molybdopterin cofactor binding site; other site 164757007560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757007561 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 164757007562 putative molybdopterin cofactor binding site; other site 164757007563 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757007564 Cytochrome P450; Region: p450; cl12078 164757007565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757007566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757007567 non-specific DNA binding site [nucleotide binding]; other site 164757007568 salt bridge; other site 164757007569 sequence-specific DNA binding site [nucleotide binding]; other site 164757007570 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 164757007571 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757007572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757007573 DNA-binding site [nucleotide binding]; DNA binding site 164757007574 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 164757007575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757007576 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757007577 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757007578 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 164757007579 hypothetical protein; Provisional; Region: PRK06815 164757007580 tetramer interface [polypeptide binding]; other site 164757007581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757007582 catalytic residue [active] 164757007583 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 164757007584 active site 164757007585 agmatinase; Region: agmatinase; TIGR01230 164757007586 Agmatinase-like family; Region: Agmatinase-like; cd09990 164757007587 active site 164757007588 oligomer interface [polypeptide binding]; other site 164757007589 Mn binding site [ion binding]; other site 164757007590 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757007591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757007592 S-adenosylmethionine binding site [chemical binding]; other site 164757007593 chorismate mutase; Provisional; Region: PRK09269 164757007594 Chorismate mutase type II; Region: CM_2; cl00693 164757007595 short chain dehydrogenase; Provisional; Region: PRK08267 164757007596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007597 NAD(P) binding site [chemical binding]; other site 164757007598 active site 164757007599 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757007600 hydrophobic ligand binding site; other site 164757007601 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757007602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757007603 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757007604 Cytochrome P450; Region: p450; cl12078 164757007605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757007606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007607 Predicted RNA-binding proteins [General function prediction only]; Region: PelA; COG1537 164757007608 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 164757007609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757007610 motif II; other site 164757007611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757007612 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 164757007613 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757007614 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757007615 active site 164757007616 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 164757007617 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757007618 short chain dehydrogenase; Provisional; Region: PRK08303 164757007619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007620 NAD(P) binding site [chemical binding]; other site 164757007621 active site 164757007622 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 164757007623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757007624 active site 164757007625 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757007626 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757007627 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 164757007628 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757007629 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757007630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757007631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757007632 putative substrate translocation pore; other site 164757007633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757007634 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 164757007635 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 164757007636 heme binding site [chemical binding]; other site 164757007637 ferroxidase pore; other site 164757007638 ferroxidase diiron center [ion binding]; other site 164757007639 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 164757007640 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757007641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757007642 substrate binding site [chemical binding]; other site 164757007643 oxyanion hole (OAH) forming residues; other site 164757007644 trimer interface [polypeptide binding]; other site 164757007645 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 164757007646 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757007647 CoenzymeA binding site [chemical binding]; other site 164757007648 subunit interaction site [polypeptide binding]; other site 164757007649 PHB binding site; other site 164757007650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757007651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 164757007652 TPR motif; other site 164757007653 TPR repeat; Region: TPR_11; pfam13414 164757007654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 164757007655 binding surface 164757007656 TPR motif; other site 164757007657 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 164757007658 nucleoside/Zn binding site; other site 164757007659 dimer interface [polypeptide binding]; other site 164757007660 catalytic motif [active] 164757007661 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 164757007662 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 164757007663 active site 164757007664 catalytic site [active] 164757007665 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 164757007666 Putative esterase; Region: Esterase; pfam00756 164757007667 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 164757007668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757007669 Walker A motif; other site 164757007670 ATP binding site [chemical binding]; other site 164757007671 Walker B motif; other site 164757007672 arginine finger; other site 164757007673 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 164757007674 TfoX N-terminal domain; Region: TfoX_N; cl17592 164757007675 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 164757007676 minor groove reading motif; other site 164757007677 helix-hairpin-helix signature motif; other site 164757007678 Protein of unknown function DUF72; Region: DUF72; pfam01904 164757007679 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 164757007680 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 164757007681 putative ligand binding site [chemical binding]; other site 164757007682 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 164757007683 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 164757007684 putative ligand binding site [chemical binding]; other site 164757007685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 164757007686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 164757007687 TM-ABC transporter signature motif; other site 164757007688 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 164757007689 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 164757007690 Walker A/P-loop; other site 164757007691 ATP binding site [chemical binding]; other site 164757007692 Q-loop/lid; other site 164757007693 ABC transporter signature motif; other site 164757007694 Walker B; other site 164757007695 D-loop; other site 164757007696 H-loop/switch region; other site 164757007697 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 164757007698 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 164757007699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757007700 NAD(P) binding site [chemical binding]; other site 164757007701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757007702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757007703 NAD(P) binding site [chemical binding]; other site 164757007704 active site 164757007705 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757007706 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 164757007707 inhibitor binding site; inhibition site 164757007708 catalytic Zn binding site [ion binding]; other site 164757007709 structural Zn binding site [ion binding]; other site 164757007710 NADP binding site [chemical binding]; other site 164757007711 tetramer interface [polypeptide binding]; other site 164757007712 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757007713 phosphate binding site [ion binding]; other site 164757007714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757007715 nucleotide binding site [chemical binding]; other site 164757007716 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 164757007717 putative active site [active] 164757007718 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 164757007719 Homeodomain-like domain; Region: HTH_23; cl17451 164757007720 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 164757007721 short chain dehydrogenase; Provisional; Region: PRK06841 164757007722 classical (c) SDRs; Region: SDR_c; cd05233 164757007723 NAD(P) binding site [chemical binding]; other site 164757007724 active site 164757007725 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 164757007726 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757007727 active site 164757007728 putative phosphoketolase; Provisional; Region: PRK05261 164757007729 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 164757007730 TPP-binding site; other site 164757007731 XFP C-terminal domain; Region: XFP_C; pfam09363 164757007732 CAAX protease self-immunity; Region: Abi; pfam02517 164757007733 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 164757007734 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 164757007735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757007736 Walker A/P-loop; other site 164757007737 ATP binding site [chemical binding]; other site 164757007738 Q-loop/lid; other site 164757007739 ABC transporter signature motif; other site 164757007740 Walker B; other site 164757007741 D-loop; other site 164757007742 H-loop/switch region; other site 164757007743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 164757007744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757007745 putative PBP binding loops; other site 164757007746 ABC-ATPase subunit interface; other site 164757007747 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 164757007748 classical (c) SDRs; Region: SDR_c; cd05233 164757007749 NAD(P) binding site [chemical binding]; other site 164757007750 active site 164757007751 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757007752 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757007753 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 164757007754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757007755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757007756 UreD urease accessory protein; Region: UreD; cl00530 164757007757 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757007758 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 164757007759 urease subunit alpha; Reviewed; Region: ureC; PRK13206 164757007760 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 164757007761 subunit interactions [polypeptide binding]; other site 164757007762 active site 164757007763 flap region; other site 164757007764 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 164757007765 gamma-beta subunit interface [polypeptide binding]; other site 164757007766 alpha-beta subunit interface [polypeptide binding]; other site 164757007767 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 164757007768 alpha-gamma subunit interface [polypeptide binding]; other site 164757007769 beta-gamma subunit interface [polypeptide binding]; other site 164757007770 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757007771 CoenzymeA binding site [chemical binding]; other site 164757007772 subunit interaction site [polypeptide binding]; other site 164757007773 PHB binding site; other site 164757007774 Predicted transcriptional regulator [Transcription]; Region: COG3682 164757007775 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 164757007776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757007777 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 164757007778 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 164757007779 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 164757007780 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757007781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 164757007782 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 164757007783 active site 164757007784 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 164757007785 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757007786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757007787 Transporter associated domain; Region: CorC_HlyC; smart01091 164757007788 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 164757007789 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757007790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757007791 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 164757007792 active site 164757007793 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 164757007794 metal ion-dependent adhesion site (MIDAS); other site 164757007795 classical (c) SDRs; Region: SDR_c; cd05233 164757007796 NAD(P) binding site [chemical binding]; other site 164757007797 active site 164757007798 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 164757007799 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 164757007800 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 164757007801 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757007802 hydrophobic ligand binding site; other site 164757007803 DoxX-like family; Region: DoxX_2; pfam13564 164757007804 PE-PPE domain; Region: PE-PPE; pfam08237 164757007805 HTH-like domain; Region: HTH_21; pfam13276 164757007806 Integrase core domain; Region: rve; pfam00665 164757007807 Integrase core domain; Region: rve_3; pfam13683 164757007808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757007809 Transposase; Region: HTH_Tnp_1; pfam01527 164757007810 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757007811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757007812 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757007813 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 164757007814 acyltransferase PapA5; Provisional; Region: PRK09294 164757007815 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 164757007816 ABC-2 type transporter; Region: ABC2_membrane; cl17235 164757007817 ABC-2 type transporter; Region: ABC2_membrane; cl17235 164757007818 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 164757007819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757007820 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 164757007821 Walker A/P-loop; other site 164757007822 ATP binding site [chemical binding]; other site 164757007823 Q-loop/lid; other site 164757007824 ABC transporter signature motif; other site 164757007825 Walker B; other site 164757007826 D-loop; other site 164757007827 H-loop/switch region; other site 164757007828 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757007829 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757007830 active site 164757007831 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757007832 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757007833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757007834 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 164757007835 putative transposase OrfB; Reviewed; Region: PHA02517 164757007836 HTH-like domain; Region: HTH_21; pfam13276 164757007837 Integrase core domain; Region: rve; pfam00665 164757007838 Integrase core domain; Region: rve_3; pfam13683 164757007839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 164757007840 Transposase; Region: HTH_Tnp_1; pfam01527 164757007841 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757007842 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757007843 active site 164757007844 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757007845 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757007846 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757007847 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757007848 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757007849 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757007850 active site 164757007851 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757007852 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757007853 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 164757007854 KR domain; Region: KR; pfam08659 164757007855 NADP binding site [chemical binding]; other site 164757007856 active site 164757007857 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757007858 acyl-CoA synthetase; Validated; Region: PRK05850 164757007859 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757007860 acyl-activating enzyme (AAE) consensus motif; other site 164757007861 active site 164757007862 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 164757007863 glycine dehydrogenase; Provisional; Region: PRK05367 164757007864 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757007865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757007866 catalytic residue [active] 164757007867 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 164757007868 tetramer interface [polypeptide binding]; other site 164757007869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757007870 catalytic residue [active] 164757007871 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 164757007872 DNA binding residues [nucleotide binding] 164757007873 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757007874 putative dimer interface [polypeptide binding]; other site 164757007875 Bifunctional nuclease; Region: DNase-RNase; pfam02577 164757007876 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 164757007877 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757007878 DNA binding residues [nucleotide binding] 164757007879 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757007880 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757007881 phosphopeptide binding site; other site 164757007882 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 164757007883 lipoyl attachment site [posttranslational modification]; other site 164757007884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 164757007885 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 164757007886 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 164757007887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 164757007888 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 164757007889 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 164757007890 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 164757007891 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 164757007892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757007893 nucleotide binding region [chemical binding]; other site 164757007894 ATP-binding site [chemical binding]; other site 164757007895 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 164757007896 hypothetical protein; Provisional; Region: PRK06184 164757007897 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757007898 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 164757007899 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 164757007900 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 164757007901 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 164757007902 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 164757007903 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 164757007904 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757007905 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 164757007906 metal binding site [ion binding]; metal-binding site 164757007907 substrate binding site [chemical binding]; other site 164757007908 dimer interface [polypeptide binding]; other site 164757007909 hypothetical protein; Validated; Region: PRK07121 164757007910 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757007911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757007912 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 164757007913 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757007914 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 164757007915 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757007916 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 164757007917 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 164757007918 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 164757007919 TrkA-C domain; Region: TrkA_C; pfam02080 164757007920 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 164757007921 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 164757007922 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 164757007923 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757007924 substrate binding pocket [chemical binding]; other site 164757007925 catalytic triad [active] 164757007926 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 164757007927 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 164757007928 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 164757007929 classical (c) SDRs; Region: SDR_c; cd05233 164757007930 NAD(P) binding site [chemical binding]; other site 164757007931 active site 164757007932 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757007933 hydrophobic ligand binding site; other site 164757007934 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757007935 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757007936 putative acyl-acceptor binding pocket; other site 164757007937 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 164757007938 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 164757007939 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 164757007940 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 164757007941 FMN-binding pocket [chemical binding]; other site 164757007942 flavin binding motif; other site 164757007943 phosphate binding motif [ion binding]; other site 164757007944 beta-alpha-beta structure motif; other site 164757007945 NAD binding pocket [chemical binding]; other site 164757007946 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757007947 catalytic loop [active] 164757007948 iron binding site [ion binding]; other site 164757007949 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757007950 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757007951 SnoaL-like domain; Region: SnoaL_4; pfam13577 164757007952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 164757007953 nudix motif; other site 164757007954 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 164757007955 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 164757007956 intracellular protease, PfpI family; Region: PfpI; TIGR01382 164757007957 proposed catalytic triad [active] 164757007958 conserved cys residue [active] 164757007959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757007960 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757007961 substrate binding pocket [chemical binding]; other site 164757007962 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 164757007963 active site 164757007964 catalytic triad [active] 164757007965 oxyanion hole [active] 164757007966 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757007967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757007968 S-adenosylmethionine binding site [chemical binding]; other site 164757007969 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 164757007970 acyl-CoA synthetase; Validated; Region: PRK07798 164757007971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757007972 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 164757007973 acyl-activating enzyme (AAE) consensus motif; other site 164757007974 acyl-activating enzyme (AAE) consensus motif; other site 164757007975 putative AMP binding site [chemical binding]; other site 164757007976 putative active site [active] 164757007977 putative CoA binding site [chemical binding]; other site 164757007978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757007979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 164757007980 PAS domain; Region: PAS_9; pfam13426 164757007981 putative active site [active] 164757007982 heme pocket [chemical binding]; other site 164757007983 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757007984 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757007985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757007986 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757007987 acyl-activating enzyme (AAE) consensus motif; other site 164757007988 acyl-activating enzyme (AAE) consensus motif; other site 164757007989 putative AMP binding site [chemical binding]; other site 164757007990 putative active site [active] 164757007991 putative CoA binding site [chemical binding]; other site 164757007992 SOUL heme-binding protein; Region: SOUL; pfam04832 164757007993 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 164757007994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757007995 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 164757007996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757007997 DNA binding residues [nucleotide binding] 164757007998 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757007999 anti sigma factor interaction site; other site 164757008000 regulatory phosphorylation site [posttranslational modification]; other site 164757008001 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 164757008002 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757008003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757008004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757008005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757008006 active site 164757008007 phosphorylation site [posttranslational modification] 164757008008 intermolecular recognition site; other site 164757008009 dimerization interface [polypeptide binding]; other site 164757008010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757008011 DNA binding site [nucleotide binding] 164757008012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757008013 dimerization interface [polypeptide binding]; other site 164757008014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757008015 dimer interface [polypeptide binding]; other site 164757008016 phosphorylation site [posttranslational modification] 164757008017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757008018 ATP binding site [chemical binding]; other site 164757008019 Mg2+ binding site [ion binding]; other site 164757008020 G-X-G motif; other site 164757008021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757008022 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757008023 active site 164757008024 ATP binding site [chemical binding]; other site 164757008025 substrate binding site [chemical binding]; other site 164757008026 activation loop (A-loop); other site 164757008027 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757008028 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757008029 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 164757008030 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 164757008031 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 164757008032 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 164757008033 GTP-binding protein Der; Reviewed; Region: PRK03003 164757008034 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 164757008035 G1 box; other site 164757008036 GTP/Mg2+ binding site [chemical binding]; other site 164757008037 Switch I region; other site 164757008038 G2 box; other site 164757008039 Switch II region; other site 164757008040 G3 box; other site 164757008041 G4 box; other site 164757008042 G5 box; other site 164757008043 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 164757008044 G1 box; other site 164757008045 GTP/Mg2+ binding site [chemical binding]; other site 164757008046 Switch I region; other site 164757008047 G2 box; other site 164757008048 G3 box; other site 164757008049 Switch II region; other site 164757008050 G4 box; other site 164757008051 G5 box; other site 164757008052 cytidylate kinase; Provisional; Region: cmk; PRK00023 164757008053 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 164757008054 active site 164757008055 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 164757008056 CMP-binding site; other site 164757008057 The sites determining sugar specificity; other site 164757008058 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 164757008059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 164757008060 RNA binding surface [nucleotide binding]; other site 164757008061 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 164757008062 active site 164757008063 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 164757008064 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 164757008065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 164757008066 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757008067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 164757008068 Magnesium ion binding site [ion binding]; other site 164757008069 MMPL family; Region: MMPL; pfam03176 164757008070 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757008071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757008072 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 164757008073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757008074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008075 homodimer interface [polypeptide binding]; other site 164757008076 catalytic residue [active] 164757008077 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 164757008078 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 164757008079 active site 164757008080 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 164757008081 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 164757008082 PYR/PP interface [polypeptide binding]; other site 164757008083 dimer interface [polypeptide binding]; other site 164757008084 TPP binding site [chemical binding]; other site 164757008085 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 164757008086 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 164757008087 TPP-binding site [chemical binding]; other site 164757008088 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757008089 Cytochrome P450; Region: p450; cl12078 164757008090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 164757008091 putative DNA binding site [nucleotide binding]; other site 164757008092 putative Zn2+ binding site [ion binding]; other site 164757008093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757008094 S-adenosylmethionine binding site [chemical binding]; other site 164757008095 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 164757008096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757008097 active site 164757008098 DNA binding site [nucleotide binding] 164757008099 Int/Topo IB signature motif; other site 164757008100 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 164757008101 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 164757008102 dimer interface [polypeptide binding]; other site 164757008103 ADP-ribose binding site [chemical binding]; other site 164757008104 active site 164757008105 nudix motif; other site 164757008106 metal binding site [ion binding]; metal-binding site 164757008107 CTP synthetase; Validated; Region: pyrG; PRK05380 164757008108 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 164757008109 active site 164757008110 UTP binding site [chemical binding]; other site 164757008111 Catalytic site [active] 164757008112 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 164757008113 active site 164757008114 putative oxyanion hole; other site 164757008115 catalytic triad [active] 164757008116 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 164757008117 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 164757008118 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 164757008119 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 164757008120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757008121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757008122 active site 164757008123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008125 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 164757008126 DNA repair protein RecN; Region: recN; TIGR00634 164757008127 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 164757008128 Walker A/P-loop; other site 164757008129 ATP binding site [chemical binding]; other site 164757008130 Q-loop/lid; other site 164757008131 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 164757008132 ABC transporter signature motif; other site 164757008133 Walker B; other site 164757008134 D-loop; other site 164757008135 H-loop/switch region; other site 164757008136 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 164757008137 ATP-NAD kinase; Region: NAD_kinase; pfam01513 164757008138 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 164757008139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 164757008140 RNA binding surface [nucleotide binding]; other site 164757008141 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 164757008142 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 164757008143 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 164757008144 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 164757008145 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 164757008146 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 164757008147 active site 164757008148 HIGH motif; other site 164757008149 dimer interface [polypeptide binding]; other site 164757008150 KMSKS motif; other site 164757008151 S4 RNA-binding domain; Region: S4; smart00363 164757008152 RNA binding surface [nucleotide binding]; other site 164757008153 3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802 164757008154 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 164757008155 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 164757008156 Walker A/P-loop; other site 164757008157 ATP binding site [chemical binding]; other site 164757008158 Q-loop/lid; other site 164757008159 ABC transporter signature motif; other site 164757008160 Walker B; other site 164757008161 D-loop; other site 164757008162 H-loop/switch region; other site 164757008163 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 164757008164 ABC-2 type transporter; Region: ABC2_membrane; cl17235 164757008165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008167 Uncharacterized conserved protein [Function unknown]; Region: COG2835 164757008168 acyl-CoA synthetase; Validated; Region: PRK07868 164757008169 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 164757008170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757008171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757008172 active site 164757008173 CoA binding site [chemical binding]; other site 164757008174 AMP binding site [chemical binding]; other site 164757008175 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 164757008176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757008177 ABC transporter; Region: ABC_tran_2; pfam12848 164757008178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757008179 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757008180 argininosuccinate lyase; Provisional; Region: PRK00855 164757008181 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 164757008182 active sites [active] 164757008183 tetramer interface [polypeptide binding]; other site 164757008184 argininosuccinate synthase; Provisional; Region: PRK13820 164757008185 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 164757008186 ANP binding site [chemical binding]; other site 164757008187 Substrate Binding Site II [chemical binding]; other site 164757008188 Substrate Binding Site I [chemical binding]; other site 164757008189 arginine repressor; Provisional; Region: PRK03341 164757008190 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 164757008191 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 164757008192 ornithine carbamoyltransferase; Provisional; Region: PRK00779 164757008193 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 164757008194 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 164757008195 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 164757008196 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757008197 inhibitor-cofactor binding pocket; inhibition site 164757008198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008199 catalytic residue [active] 164757008200 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 164757008201 feedback inhibition sensing region; other site 164757008202 homohexameric interface [polypeptide binding]; other site 164757008203 nucleotide binding site [chemical binding]; other site 164757008204 N-acetyl-L-glutamate binding site [chemical binding]; other site 164757008205 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 164757008206 heterotetramer interface [polypeptide binding]; other site 164757008207 active site pocket [active] 164757008208 cleavage site 164757008209 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 164757008210 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 164757008211 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 164757008212 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 164757008213 putative tRNA-binding site [nucleotide binding]; other site 164757008214 B3/4 domain; Region: B3_4; pfam03483 164757008215 tRNA synthetase B5 domain; Region: B5; smart00874 164757008216 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 164757008217 dimer interface [polypeptide binding]; other site 164757008218 motif 1; other site 164757008219 motif 3; other site 164757008220 motif 2; other site 164757008221 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 164757008222 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 164757008223 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 164757008224 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 164757008225 dimer interface [polypeptide binding]; other site 164757008226 motif 1; other site 164757008227 active site 164757008228 motif 2; other site 164757008229 motif 3; other site 164757008230 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757008231 cyclase homology domain; Region: CHD; cd07302 164757008232 nucleotidyl binding site; other site 164757008233 metal binding site [ion binding]; metal-binding site 164757008234 dimer interface [polypeptide binding]; other site 164757008235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 164757008236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757008237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757008238 active site 164757008239 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 164757008240 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 164757008241 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 164757008242 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 164757008243 23S rRNA binding site [nucleotide binding]; other site 164757008244 L21 binding site [polypeptide binding]; other site 164757008245 L13 binding site [polypeptide binding]; other site 164757008246 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 164757008247 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 164757008248 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 164757008249 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 164757008250 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 164757008251 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 164757008252 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 164757008253 dimer interface [polypeptide binding]; other site 164757008254 putative anticodon binding site; other site 164757008255 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 164757008256 motif 1; other site 164757008257 dimer interface [polypeptide binding]; other site 164757008258 active site 164757008259 motif 2; other site 164757008260 motif 3; other site 164757008261 Predicted esterase [General function prediction only]; Region: COG0627 164757008262 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 164757008263 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 164757008264 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757008265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757008266 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 164757008267 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 164757008268 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 164757008269 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 164757008270 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 164757008271 Domain of unknown function (DUF427); Region: DUF427; pfam04248 164757008272 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757008273 Cytochrome P450; Region: p450; cl12078 164757008274 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757008275 Ligand Binding Site [chemical binding]; other site 164757008276 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 164757008277 Fe-S cluster binding site [ion binding]; other site 164757008278 active site 164757008279 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 164757008280 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757008281 active site 164757008282 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757008283 catalytic triad [active] 164757008284 dimer interface [polypeptide binding]; other site 164757008285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757008286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757008287 dimer interface [polypeptide binding]; other site 164757008288 phosphorylation site [posttranslational modification] 164757008289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757008290 ATP binding site [chemical binding]; other site 164757008291 Mg2+ binding site [ion binding]; other site 164757008292 G-X-G motif; other site 164757008293 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 164757008294 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 164757008295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757008296 putative metal binding site [ion binding]; other site 164757008297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757008298 dimerization interface [polypeptide binding]; other site 164757008299 putative DNA binding site [nucleotide binding]; other site 164757008300 putative Zn2+ binding site [ion binding]; other site 164757008301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757008302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757008303 putative substrate translocation pore; other site 164757008304 excinuclease ABC subunit B; Provisional; Region: PRK05298 164757008305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757008306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757008307 nucleotide binding region [chemical binding]; other site 164757008308 ATP-binding site [chemical binding]; other site 164757008309 Ultra-violet resistance protein B; Region: UvrB; pfam12344 164757008310 UvrB/uvrC motif; Region: UVR; pfam02151 164757008311 Protein of unknown function (DUF402); Region: DUF402; cl00979 164757008312 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 164757008313 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 164757008314 CoA-binding site [chemical binding]; other site 164757008315 ATP-binding [chemical binding]; other site 164757008316 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 164757008317 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 164757008318 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 164757008319 RNA binding site [nucleotide binding]; other site 164757008320 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 164757008321 RNA binding site [nucleotide binding]; other site 164757008322 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 164757008323 RNA binding site [nucleotide binding]; other site 164757008324 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 164757008325 RNA binding site [nucleotide binding]; other site 164757008326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757008329 NADH(P)-binding; Region: NAD_binding_10; pfam13460 164757008330 NAD(P) binding site [chemical binding]; other site 164757008331 active site 164757008332 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 164757008333 Protease prsW family; Region: PrsW-protease; pfam13367 164757008334 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 164757008335 5'-3' exonuclease; Region: 53EXOc; smart00475 164757008336 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 164757008337 active site 164757008338 metal binding site 1 [ion binding]; metal-binding site 164757008339 putative 5' ssDNA interaction site; other site 164757008340 metal binding site 3; metal-binding site 164757008341 metal binding site 2 [ion binding]; metal-binding site 164757008342 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 164757008343 putative DNA binding site [nucleotide binding]; other site 164757008344 putative metal binding site [ion binding]; other site 164757008345 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 164757008346 active site 164757008347 substrate binding site [chemical binding]; other site 164757008348 DNA polymerase I; Provisional; Region: PRK05755 164757008349 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 164757008350 active site 164757008351 DNA binding site [nucleotide binding] 164757008352 catalytic site [active] 164757008353 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 164757008354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757008355 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 164757008356 putative dimerization interface [polypeptide binding]; other site 164757008357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757008358 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 164757008359 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757008360 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757008361 lipid-transfer protein; Provisional; Region: PRK06059 164757008362 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757008363 active site 164757008364 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 164757008365 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 164757008366 Walker A/P-loop; other site 164757008367 ATP binding site [chemical binding]; other site 164757008368 Q-loop/lid; other site 164757008369 ABC transporter signature motif; other site 164757008370 Walker B; other site 164757008371 D-loop; other site 164757008372 H-loop/switch region; other site 164757008373 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 164757008374 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 164757008375 Walker A/P-loop; other site 164757008376 ATP binding site [chemical binding]; other site 164757008377 Q-loop/lid; other site 164757008378 ABC transporter signature motif; other site 164757008379 Walker B; other site 164757008380 D-loop; other site 164757008381 H-loop/switch region; other site 164757008382 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 164757008383 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 164757008384 TM-ABC transporter signature motif; other site 164757008385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 164757008386 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 164757008387 TM-ABC transporter signature motif; other site 164757008388 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 164757008389 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 164757008390 dimerization interface [polypeptide binding]; other site 164757008391 ligand binding site [chemical binding]; other site 164757008392 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 164757008393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757008394 active site 164757008395 phosphorylation site [posttranslational modification] 164757008396 intermolecular recognition site; other site 164757008397 dimerization interface [polypeptide binding]; other site 164757008398 ANTAR domain; Region: ANTAR; pfam03861 164757008399 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 164757008400 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 164757008401 agmatinase; Region: agmatinase; TIGR01230 164757008402 oligomer interface [polypeptide binding]; other site 164757008403 putative active site [active] 164757008404 Mn binding site [ion binding]; other site 164757008405 Heme NO binding associated; Region: HNOBA; pfam07701 164757008406 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 164757008407 cyclase homology domain; Region: CHD; cd07302 164757008408 nucleotidyl binding site; other site 164757008409 metal binding site [ion binding]; metal-binding site 164757008410 dimer interface [polypeptide binding]; other site 164757008411 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 164757008412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757008413 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757008414 hydrophobic ligand binding site; other site 164757008415 Ferritin-like domain; Region: Ferritin; pfam00210 164757008416 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 164757008417 dimerization interface [polypeptide binding]; other site 164757008418 DPS ferroxidase diiron center [ion binding]; other site 164757008419 ion pore; other site 164757008420 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757008421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757008422 active site 164757008423 phosphorylation site [posttranslational modification] 164757008424 intermolecular recognition site; other site 164757008425 dimerization interface [polypeptide binding]; other site 164757008426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757008427 DNA binding residues [nucleotide binding] 164757008428 dimerization interface [polypeptide binding]; other site 164757008429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757008430 ATP binding site [chemical binding]; other site 164757008431 G-X-G motif; other site 164757008432 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757008433 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 164757008434 Walker A/P-loop; other site 164757008435 ATP binding site [chemical binding]; other site 164757008436 Q-loop/lid; other site 164757008437 ABC transporter signature motif; other site 164757008438 Walker B; other site 164757008439 D-loop; other site 164757008440 H-loop/switch region; other site 164757008441 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 164757008442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757008443 dimer interface [polypeptide binding]; other site 164757008444 conserved gate region; other site 164757008445 putative PBP binding loops; other site 164757008446 ABC-ATPase subunit interface; other site 164757008447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757008448 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757008449 substrate binding pocket [chemical binding]; other site 164757008450 membrane-bound complex binding site; other site 164757008451 hinge residues; other site 164757008452 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 164757008453 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 164757008454 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 164757008455 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 164757008456 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 164757008457 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 164757008458 Walker A/P-loop; other site 164757008459 ATP binding site [chemical binding]; other site 164757008460 Q-loop/lid; other site 164757008461 ABC transporter signature motif; other site 164757008462 Walker B; other site 164757008463 D-loop; other site 164757008464 H-loop/switch region; other site 164757008465 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 164757008466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757008467 Walker A/P-loop; other site 164757008468 ATP binding site [chemical binding]; other site 164757008469 Q-loop/lid; other site 164757008470 ABC transporter signature motif; other site 164757008471 Walker B; other site 164757008472 D-loop; other site 164757008473 H-loop/switch region; other site 164757008474 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 164757008475 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757008476 active site 164757008477 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757008478 catalytic triad [active] 164757008479 dimer interface [polypeptide binding]; other site 164757008480 pyruvate kinase; Provisional; Region: PRK06247 164757008481 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 164757008482 domain interfaces; other site 164757008483 active site 164757008484 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 164757008485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757008486 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 164757008487 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 164757008488 active site 164757008489 dimer interface [polypeptide binding]; other site 164757008490 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 164757008491 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 164757008492 active site 164757008493 FMN binding site [chemical binding]; other site 164757008494 substrate binding site [chemical binding]; other site 164757008495 3Fe-4S cluster binding site [ion binding]; other site 164757008496 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 164757008497 domain interface; other site 164757008498 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 164757008499 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757008500 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757008501 active site 164757008502 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 164757008503 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 164757008504 substrate binding site [chemical binding]; other site 164757008505 active site 164757008506 catalytic residues [active] 164757008507 heterodimer interface [polypeptide binding]; other site 164757008508 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 164757008509 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 164757008510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008511 catalytic residue [active] 164757008512 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 164757008513 active site 164757008514 ribulose/triose binding site [chemical binding]; other site 164757008515 phosphate binding site [ion binding]; other site 164757008516 substrate (anthranilate) binding pocket [chemical binding]; other site 164757008517 product (indole) binding pocket [chemical binding]; other site 164757008518 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 164757008519 anthranilate synthase component I; Provisional; Region: PRK13571 164757008520 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 164757008521 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 164757008522 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 164757008523 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 164757008524 catalytic triad [active] 164757008525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757008526 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757008527 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 164757008528 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 164757008529 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 164757008530 substrate binding site [chemical binding]; other site 164757008531 glutamase interaction surface [polypeptide binding]; other site 164757008532 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 164757008533 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 164757008534 active site 164757008535 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 164757008536 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 164757008537 catalytic residues [active] 164757008538 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 164757008539 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 164757008540 putative active site [active] 164757008541 oxyanion strand; other site 164757008542 catalytic triad [active] 164757008543 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 164757008544 putative active site pocket [active] 164757008545 4-fold oligomerization interface [polypeptide binding]; other site 164757008546 metal binding residues [ion binding]; metal-binding site 164757008547 3-fold/trimer interface [polypeptide binding]; other site 164757008548 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 164757008549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757008550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008551 homodimer interface [polypeptide binding]; other site 164757008552 catalytic residue [active] 164757008553 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 164757008554 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 164757008555 NAD binding site [chemical binding]; other site 164757008556 dimerization interface [polypeptide binding]; other site 164757008557 product binding site; other site 164757008558 substrate binding site [chemical binding]; other site 164757008559 zinc binding site [ion binding]; other site 164757008560 catalytic residues [active] 164757008561 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757008562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757008563 non-specific DNA binding site [nucleotide binding]; other site 164757008564 salt bridge; other site 164757008565 sequence-specific DNA binding site [nucleotide binding]; other site 164757008566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 164757008567 active site 164757008568 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 164757008569 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 164757008570 dimerization interface [polypeptide binding]; other site 164757008571 active site 164757008572 L-aspartate oxidase; Provisional; Region: PRK07804 164757008573 L-aspartate oxidase; Provisional; Region: PRK06175 164757008574 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 164757008575 quinolinate synthetase; Provisional; Region: PRK09375 164757008576 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 164757008577 nudix motif; other site 164757008578 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 164757008579 Secretory lipase; Region: LIP; pfam03583 164757008580 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 164757008581 biotin synthase; Validated; Region: PRK06256 164757008582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757008583 FeS/SAM binding site; other site 164757008584 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 164757008585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008586 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 164757008587 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 164757008588 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 164757008589 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 164757008590 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 164757008591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757008592 catalytic residue [active] 164757008593 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 164757008594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757008595 inhibitor-cofactor binding pocket; inhibition site 164757008596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008597 catalytic residue [active] 164757008598 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757008599 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 164757008600 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 164757008601 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 164757008602 active site 164757008603 catalytic site [active] 164757008604 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 164757008605 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 164757008606 active site 164757008607 catalytic site [active] 164757008608 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 164757008609 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 164757008610 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 164757008611 catalytic site [active] 164757008612 active site 164757008613 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 164757008614 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 164757008615 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 164757008616 homodimer interface [polypeptide binding]; other site 164757008617 active site 164757008618 TDP-binding site; other site 164757008619 acceptor substrate-binding pocket; other site 164757008620 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 164757008621 threonine dehydratase; Validated; Region: PRK08639 164757008622 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 164757008623 tetramer interface [polypeptide binding]; other site 164757008624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757008625 catalytic residue [active] 164757008626 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 164757008627 putative Ile/Val binding site [chemical binding]; other site 164757008628 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757008629 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 164757008630 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 164757008631 active site 164757008632 PHP Thumb interface [polypeptide binding]; other site 164757008633 metal binding site [ion binding]; metal-binding site 164757008634 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 164757008635 generic binding surface II; other site 164757008636 generic binding surface I; other site 164757008637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008639 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 164757008640 YCII-related domain; Region: YCII; cl00999 164757008641 Predicted permeases [General function prediction only]; Region: RarD; COG2962 164757008642 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 164757008643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 164757008644 RNA binding surface [nucleotide binding]; other site 164757008645 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 164757008646 active site 164757008647 lipoprotein signal peptidase; Provisional; Region: PRK14764 164757008648 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 164757008649 active site 164757008650 homotetramer interface [polypeptide binding]; other site 164757008651 homodimer interface [polypeptide binding]; other site 164757008652 DNA polymerase IV; Provisional; Region: PRK03348 164757008653 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 164757008654 active site 164757008655 DNA binding site [nucleotide binding] 164757008656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 164757008657 RNA binding surface [nucleotide binding]; other site 164757008658 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757008659 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 164757008660 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757008661 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 164757008662 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 164757008663 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 164757008664 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 164757008665 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757008666 active site 164757008667 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 164757008668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 164757008669 HIGH motif; other site 164757008670 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 164757008671 active site 164757008672 KMSKS motif; other site 164757008673 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 164757008674 tRNA binding surface [nucleotide binding]; other site 164757008675 anticodon binding site; other site 164757008676 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 164757008677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 164757008678 acyl-CoA synthetase; Validated; Region: PRK05850 164757008679 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757008680 acyl-activating enzyme (AAE) consensus motif; other site 164757008681 active site 164757008682 Transport protein; Region: actII; TIGR00833 164757008683 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 164757008684 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 164757008685 TDP-binding site; other site 164757008686 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757008687 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757008688 Condensation domain; Region: Condensation; pfam00668 164757008689 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 164757008690 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757008691 active site 164757008692 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757008693 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 164757008694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757008695 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 164757008696 Enoylreductase; Region: PKS_ER; smart00829 164757008697 NAD(P) binding site [chemical binding]; other site 164757008698 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 164757008699 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 164757008700 putative NADP binding site [chemical binding]; other site 164757008701 active site 164757008702 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757008703 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757008704 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757008705 membrane ATPase/protein kinase; Provisional; Region: PRK09435 164757008706 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 164757008707 Walker A; other site 164757008708 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 164757008709 G4 box; other site 164757008710 G5 box; other site 164757008711 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 164757008712 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 164757008713 active site 164757008714 substrate binding site [chemical binding]; other site 164757008715 coenzyme B12 binding site [chemical binding]; other site 164757008716 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 164757008717 B12 binding site [chemical binding]; other site 164757008718 cobalt ligand [ion binding]; other site 164757008719 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 164757008720 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 164757008721 heterodimer interface [polypeptide binding]; other site 164757008722 substrate interaction site [chemical binding]; other site 164757008723 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 164757008724 Uncharacterized conserved protein [Function unknown]; Region: COG0398 164757008725 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 164757008726 DoxX-like family; Region: DoxX_2; pfam13564 164757008727 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 164757008728 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 164757008729 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 164757008730 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 164757008731 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 164757008732 active site 164757008733 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 164757008734 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 164757008735 active site 164757008736 Pup-like protein; Region: Pup; cl05289 164757008737 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 164757008738 proteasome ATPase; Region: pup_AAA; TIGR03689 164757008739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757008740 Walker A motif; other site 164757008741 ATP binding site [chemical binding]; other site 164757008742 Walker B motif; other site 164757008743 arginine finger; other site 164757008744 Protein of unknown function (DUF503); Region: DUF503; pfam04456 164757008745 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 164757008746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757008747 S-adenosylmethionine binding site [chemical binding]; other site 164757008748 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 164757008749 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757008750 DinB superfamily; Region: DinB_2; pfam12867 164757008751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008752 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 164757008753 putative dimer interface [polypeptide binding]; other site 164757008754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757008755 mercuric reductase; Validated; Region: PRK06370 164757008756 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757008757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757008758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 164757008759 Predicted membrane protein [Function unknown]; Region: COG3918 164757008760 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 164757008761 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 164757008762 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 164757008763 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 164757008764 homodimer interface [polypeptide binding]; other site 164757008765 putative metal binding site [ion binding]; other site 164757008766 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 164757008767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757008768 putative substrate translocation pore; other site 164757008769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757008770 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 164757008771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757008772 motif II; other site 164757008773 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 164757008774 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 164757008775 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 164757008776 substrate binding pocket [chemical binding]; other site 164757008777 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 164757008778 B12 binding site [chemical binding]; other site 164757008779 cobalt ligand [ion binding]; other site 164757008780 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 164757008781 PAC2 family; Region: PAC2; pfam09754 164757008782 Uncharacterized conserved protein [Function unknown]; Region: COG5361 164757008783 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 164757008784 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 164757008785 short chain dehydrogenase; Provisional; Region: PRK05872 164757008786 classical (c) SDRs; Region: SDR_c; cd05233 164757008787 NAD(P) binding site [chemical binding]; other site 164757008788 active site 164757008789 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 164757008790 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 164757008791 active site 164757008792 HIGH motif; other site 164757008793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 164757008794 active site 164757008795 KMSKS motif; other site 164757008796 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 164757008797 putative tRNA binding surface [nucleotide binding]; other site 164757008798 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 164757008799 active site 164757008800 conserved hypothetical protein; Region: TIGR03843 164757008801 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 164757008802 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757008803 catalytic core [active] 164757008804 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 164757008805 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 164757008806 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 164757008807 quinone interaction residues [chemical binding]; other site 164757008808 active site 164757008809 catalytic residues [active] 164757008810 FMN binding site [chemical binding]; other site 164757008811 substrate binding site [chemical binding]; other site 164757008812 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 164757008813 substrate binding site [chemical binding]; other site 164757008814 hypothetical protein; Provisional; Region: PRK07906 164757008815 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 164757008816 putative metal binding site [ion binding]; other site 164757008817 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 164757008818 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 164757008819 catalytic residues [active] 164757008820 catalytic nucleophile [active] 164757008821 Recombinase; Region: Recombinase; pfam07508 164757008822 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 164757008823 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757008824 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757008825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757008826 non-specific DNA binding site [nucleotide binding]; other site 164757008827 salt bridge; other site 164757008828 sequence-specific DNA binding site [nucleotide binding]; other site 164757008829 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 164757008830 nudix motif; other site 164757008831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757008832 Zn2+ binding site [ion binding]; other site 164757008833 Mg2+ binding site [ion binding]; other site 164757008834 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 164757008835 ThiF family; Region: ThiF; pfam00899 164757008836 ATP binding site [chemical binding]; other site 164757008837 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 164757008838 active site 164757008839 NTP binding site [chemical binding]; other site 164757008840 metal binding triad [ion binding]; metal-binding site 164757008841 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 164757008842 active site 164757008843 nucleophile elbow; other site 164757008844 putative transposase OrfB; Reviewed; Region: PHA02517 164757008845 Integrase core domain; Region: rve; pfam00665 164757008846 Integrase core domain; Region: rve_2; pfam13333 164757008847 Integrase core domain; Region: rve; pfam00665 164757008848 Integrase core domain; Region: rve_3; cl15866 164757008849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757008850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757008851 active site 164757008852 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757008853 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757008854 NAD binding site [chemical binding]; other site 164757008855 catalytic Zn binding site [ion binding]; other site 164757008856 substrate binding site [chemical binding]; other site 164757008857 structural Zn binding site [ion binding]; other site 164757008858 SCP-2 sterol transfer family; Region: SCP2; pfam02036 164757008859 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 164757008860 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 164757008861 putative active site [active] 164757008862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757008863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757008864 active site 164757008865 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757008866 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 164757008867 dimer interface [polypeptide binding]; other site 164757008868 acyl-activating enzyme (AAE) consensus motif; other site 164757008869 putative active site [active] 164757008870 AMP binding site [chemical binding]; other site 164757008871 putative CoA binding site [chemical binding]; other site 164757008872 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 164757008873 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 164757008874 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 164757008875 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 164757008876 Cytochrome P450; Region: p450; cl12078 164757008877 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757008878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757008879 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 164757008880 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757008881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757008882 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757008883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757008884 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757008885 classical (c) SDRs; Region: SDR_c; cd05233 164757008886 NAD(P) binding site [chemical binding]; other site 164757008887 active site 164757008888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008890 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 164757008891 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 164757008892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008893 Transposase; Region: HTH_Tnp_1; cl17663 164757008894 putative transposase OrfB; Reviewed; Region: PHA02517 164757008895 HTH-like domain; Region: HTH_21; pfam13276 164757008896 Integrase core domain; Region: rve; pfam00665 164757008897 Integrase core domain; Region: rve_3; cl15866 164757008898 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 164757008899 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757008900 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757008901 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 164757008902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757008903 carboxyltransferase (CT) interaction site; other site 164757008904 biotinylation site [posttranslational modification]; other site 164757008905 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757008906 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757008907 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757008908 active site 164757008909 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757008910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757008911 acyl-activating enzyme (AAE) consensus motif; other site 164757008912 AMP binding site [chemical binding]; other site 164757008913 active site 164757008914 CoA binding site [chemical binding]; other site 164757008915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008917 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 164757008918 TIGR03084 family protein; Region: TIGR03084 164757008919 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757008920 Wyosine base formation; Region: Wyosine_form; pfam08608 164757008921 enoyl-CoA hydratase; Provisional; Region: PRK06494 164757008922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757008923 substrate binding site [chemical binding]; other site 164757008924 oxyanion hole (OAH) forming residues; other site 164757008925 trimer interface [polypeptide binding]; other site 164757008926 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757008927 active site 2 [active] 164757008928 active site 1 [active] 164757008929 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 164757008930 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757008931 active site 2 [active] 164757008932 active site 1 [active] 164757008933 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757008934 active site 164757008935 catalytic site [active] 164757008936 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757008937 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 164757008938 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757008939 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757008940 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757008941 thiolase; Provisional; Region: PRK06158 164757008942 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757008943 active site 164757008944 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 164757008945 Helix-turn-helix domain; Region: HTH_18; pfam12833 164757008946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757008947 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 164757008948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757008949 catalytic loop [active] 164757008950 iron binding site [ion binding]; other site 164757008951 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757008952 Cytochrome P450; Region: p450; cl12078 164757008953 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 164757008954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757008955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757008956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757008959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757008960 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757008961 CoenzymeA binding site [chemical binding]; other site 164757008962 subunit interaction site [polypeptide binding]; other site 164757008963 PHB binding site; other site 164757008964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757008965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757008966 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 164757008967 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 164757008968 active site 164757008969 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757008970 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 164757008971 NAD(P) binding site [chemical binding]; other site 164757008972 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757008973 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757008974 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 164757008975 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 164757008976 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 164757008977 [4Fe-4S] binding site [ion binding]; other site 164757008978 molybdopterin cofactor binding site; other site 164757008979 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 164757008980 molybdopterin cofactor binding site; other site 164757008981 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 164757008982 Flavodoxin; Region: Flavodoxin_1; pfam00258 164757008983 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 164757008984 FAD binding pocket [chemical binding]; other site 164757008985 FAD binding motif [chemical binding]; other site 164757008986 catalytic residues [active] 164757008987 NAD binding pocket [chemical binding]; other site 164757008988 phosphate binding motif [ion binding]; other site 164757008989 beta-alpha-beta structure motif; other site 164757008990 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 164757008991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757008992 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 164757008993 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757008994 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757008995 iron-sulfur cluster [ion binding]; other site 164757008996 [2Fe-2S] cluster binding site [ion binding]; other site 164757008997 PknH-like extracellular domain; Region: PknH_C; pfam14032 164757008998 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757008999 Ligand Binding Site [chemical binding]; other site 164757009000 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 164757009001 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 164757009002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 164757009003 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 164757009004 PAS domain; Region: PAS; smart00091 164757009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757009006 ATP binding site [chemical binding]; other site 164757009007 Mg2+ binding site [ion binding]; other site 164757009008 G-X-G motif; other site 164757009009 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 164757009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757009011 active site 164757009012 phosphorylation site [posttranslational modification] 164757009013 intermolecular recognition site; other site 164757009014 dimerization interface [polypeptide binding]; other site 164757009015 Transcriptional regulator; Region: CitT; pfam12431 164757009016 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757009017 Cytochrome P450; Region: p450; cl12078 164757009018 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 164757009019 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 164757009020 putative active site [active] 164757009021 catalytic site [active] 164757009022 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 164757009023 putative active site [active] 164757009024 catalytic site [active] 164757009025 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757009026 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757009027 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 164757009028 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 164757009029 catalytic triad [active] 164757009030 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 164757009031 putative hydrophobic ligand binding site [chemical binding]; other site 164757009032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757009033 TIGR01777 family protein; Region: yfcH 164757009034 NAD(P) binding site [chemical binding]; other site 164757009035 active site 164757009036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757009037 active site 164757009038 DivIVA domain; Region: DivI1A_domain; TIGR03544 164757009039 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 164757009040 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 164757009041 Predicted integral membrane protein [Function unknown]; Region: COG0762 164757009042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 164757009043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 164757009044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 164757009045 catalytic residue [active] 164757009046 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 164757009047 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 164757009048 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 164757009049 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 164757009050 nucleotide binding site [chemical binding]; other site 164757009051 SulA interaction site; other site 164757009052 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 164757009053 Cell division protein FtsQ; Region: FtsQ; pfam03799 164757009054 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 164757009055 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 164757009056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 164757009057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 164757009058 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 164757009059 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 164757009060 active site 164757009061 homodimer interface [polypeptide binding]; other site 164757009062 cell division protein FtsW; Region: ftsW; TIGR02614 164757009063 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 164757009064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 164757009065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 164757009066 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 164757009067 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 164757009068 Mg++ binding site [ion binding]; other site 164757009069 putative catalytic motif [active] 164757009070 putative substrate binding site [chemical binding]; other site 164757009071 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 164757009072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 164757009073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 164757009074 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 164757009075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 164757009076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 164757009077 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 164757009078 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 164757009079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 164757009080 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 164757009081 MraW methylase family; Region: Methyltransf_5; pfam01795 164757009082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 164757009083 MraZ protein; Region: MraZ; pfam02381 164757009084 MraZ protein; Region: MraZ; pfam02381 164757009085 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 164757009086 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 164757009087 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 164757009088 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 164757009089 substrate binding pocket [chemical binding]; other site 164757009090 chain length determination region; other site 164757009091 substrate-Mg2+ binding site; other site 164757009092 catalytic residues [active] 164757009093 aspartate-rich region 1; other site 164757009094 active site lid residues [active] 164757009095 aspartate-rich region 2; other site 164757009096 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 164757009097 Helix-turn-helix domain; Region: HTH_17; cl17695 164757009098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757009099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757009100 active site 164757009101 ATP binding site [chemical binding]; other site 164757009102 substrate binding site [chemical binding]; other site 164757009103 activation loop (A-loop); other site 164757009104 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 164757009105 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 164757009106 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757009107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 164757009108 putative acyl-acceptor binding pocket; other site 164757009109 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 164757009110 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 164757009111 P loop; other site 164757009112 Nucleotide binding site [chemical binding]; other site 164757009113 DTAP/Switch II; other site 164757009114 Switch I; other site 164757009115 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757009116 putative hydrophobic ligand binding site [chemical binding]; other site 164757009117 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 164757009118 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 164757009119 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 164757009120 acyl-activating enzyme (AAE) consensus motif; other site 164757009121 putative AMP binding site [chemical binding]; other site 164757009122 putative active site [active] 164757009123 putative CoA binding site [chemical binding]; other site 164757009124 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 164757009125 agmatinase; Region: agmatinase; TIGR01230 164757009126 oligomer interface [polypeptide binding]; other site 164757009127 putative active site [active] 164757009128 Mn binding site [ion binding]; other site 164757009129 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 164757009130 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757009131 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757009132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757009133 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 164757009134 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757009135 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757009136 hypothetical protein; Validated; Region: PRK07883 164757009137 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 164757009138 active site 164757009139 catalytic site [active] 164757009140 substrate binding site [chemical binding]; other site 164757009141 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 164757009142 GIY-YIG motif/motif A; other site 164757009143 active site 164757009144 catalytic site [active] 164757009145 putative DNA binding site [nucleotide binding]; other site 164757009146 metal binding site [ion binding]; metal-binding site 164757009147 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 164757009148 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 164757009149 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 164757009150 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 164757009151 Subunit I/III interface [polypeptide binding]; other site 164757009152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 164757009153 Cytochrome c; Region: Cytochrom_C; pfam00034 164757009154 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 164757009155 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 164757009156 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 164757009157 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 164757009158 iron-sulfur cluster [ion binding]; other site 164757009159 [2Fe-2S] cluster binding site [ion binding]; other site 164757009160 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 164757009161 heme bH binding site [chemical binding]; other site 164757009162 intrachain domain interface; other site 164757009163 heme bL binding site [chemical binding]; other site 164757009164 interchain domain interface [polypeptide binding]; other site 164757009165 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 164757009166 Qo binding site; other site 164757009167 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 164757009168 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 164757009169 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 164757009170 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 164757009171 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 164757009172 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 164757009173 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 164757009174 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 164757009175 active site 164757009176 dimer interface [polypeptide binding]; other site 164757009177 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 164757009178 Ligand Binding Site [chemical binding]; other site 164757009179 Molecular Tunnel; other site 164757009180 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 164757009181 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 164757009182 substrate binding site [chemical binding]; other site 164757009183 ATP binding site [chemical binding]; other site 164757009184 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 164757009185 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 164757009186 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 164757009187 homotrimer interface [polypeptide binding]; other site 164757009188 Walker A motif; other site 164757009189 GTP binding site [chemical binding]; other site 164757009190 Walker B motif; other site 164757009191 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 164757009192 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 164757009193 putative dimer interface [polypeptide binding]; other site 164757009194 active site pocket [active] 164757009195 putative cataytic base [active] 164757009196 cobalamin synthase; Reviewed; Region: cobS; PRK00235 164757009197 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 164757009198 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 164757009199 homodimer interface [polypeptide binding]; other site 164757009200 substrate-cofactor binding pocket; other site 164757009201 catalytic residue [active] 164757009202 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 164757009203 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 164757009204 multifunctional aminopeptidase A; Provisional; Region: PRK00913 164757009205 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 164757009206 interface (dimer of trimers) [polypeptide binding]; other site 164757009207 Substrate-binding/catalytic site; other site 164757009208 Zn-binding sites [ion binding]; other site 164757009209 short chain dehydrogenase; Validated; Region: PRK05855 164757009210 classical (c) SDRs; Region: SDR_c; cd05233 164757009211 NAD(P) binding site [chemical binding]; other site 164757009212 active site 164757009213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 164757009214 E3 interaction surface; other site 164757009215 lipoyl attachment site [posttranslational modification]; other site 164757009216 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 164757009217 E3 interaction surface; other site 164757009218 lipoyl attachment site [posttranslational modification]; other site 164757009219 e3 binding domain; Region: E3_binding; pfam02817 164757009220 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 164757009221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 164757009222 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 164757009223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757009224 NAD(P) binding site [chemical binding]; other site 164757009225 active site 164757009226 lipoate-protein ligase B; Provisional; Region: PRK14345 164757009227 lipoyl synthase; Provisional; Region: PRK05481 164757009228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757009229 FeS/SAM binding site; other site 164757009230 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 164757009231 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 164757009232 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 164757009233 active site 164757009234 RDD family; Region: RDD; pfam06271 164757009235 glutamine synthetase, type I; Region: GlnA; TIGR00653 164757009236 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 164757009237 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757009238 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 164757009239 putative active site [active] 164757009240 dimerization interface [polypeptide binding]; other site 164757009241 putative tRNAtyr binding site [nucleotide binding]; other site 164757009242 DoxX; Region: DoxX; pfam07681 164757009243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757009244 B12 binding domain; Region: B12-binding_2; pfam02607 164757009245 B12 binding domain; Region: B12-binding; pfam02310 164757009246 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757009247 anti sigma factor interaction site; other site 164757009248 regulatory phosphorylation site [posttranslational modification]; other site 164757009249 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757009250 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757009251 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 164757009252 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 164757009253 metal binding triad; other site 164757009254 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 164757009255 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 164757009256 metal binding triad; other site 164757009257 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 164757009258 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 164757009259 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 164757009260 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757009261 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 164757009262 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757009263 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 164757009264 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757009265 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757009266 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757009267 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757009268 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 164757009269 oligomerization interface [polypeptide binding]; other site 164757009270 active site 164757009271 metal binding site [ion binding]; metal-binding site 164757009272 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757009273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757009274 substrate binding site [chemical binding]; other site 164757009275 oxyanion hole (OAH) forming residues; other site 164757009276 trimer interface [polypeptide binding]; other site 164757009277 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 164757009278 putative active site; other site 164757009279 putative metal binding residues [ion binding]; other site 164757009280 signature motif; other site 164757009281 putative triphosphate binding site [ion binding]; other site 164757009282 CHAD domain; Region: CHAD; pfam05235 164757009283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757009284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757009285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757009286 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 164757009287 RibD C-terminal domain; Region: RibD_C; cl17279 164757009288 CAAX protease self-immunity; Region: Abi; pfam02517 164757009289 Methyltransferase domain; Region: Methyltransf_31; pfam13847 164757009290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757009291 S-adenosylmethionine binding site [chemical binding]; other site 164757009292 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 164757009293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757009294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757009295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757009296 sequence-specific DNA binding site [nucleotide binding]; other site 164757009297 salt bridge; other site 164757009298 Cupin domain; Region: Cupin_2; pfam07883 164757009299 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 164757009300 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 164757009301 RNA/DNA hybrid binding site [nucleotide binding]; other site 164757009302 active site 164757009303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757009304 catalytic core [active] 164757009305 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 164757009306 Putative zinc ribbon domain; Region: DUF164; pfam02591 164757009307 Uncharacterized conserved protein [Function unknown]; Region: COG0327 164757009308 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 164757009309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 164757009310 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 164757009311 hypothetical protein; Provisional; Region: PRK07908 164757009312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757009313 homodimer interface [polypeptide binding]; other site 164757009314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757009315 catalytic residue [active] 164757009316 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 164757009317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757009318 motif II; other site 164757009319 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 164757009320 Low molecular weight phosphatase family; Region: LMWPc; cd00115 164757009321 active site 164757009322 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 164757009323 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 164757009324 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757009325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757009326 DNA binding residues [nucleotide binding] 164757009327 dimerization interface [polypeptide binding]; other site 164757009328 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 164757009329 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 164757009330 glutaminase active site [active] 164757009331 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 164757009332 dimer interface [polypeptide binding]; other site 164757009333 active site 164757009334 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 164757009335 dimer interface [polypeptide binding]; other site 164757009336 active site 164757009337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757009338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757009339 NAD(P) binding site [chemical binding]; other site 164757009340 active site 164757009341 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 164757009342 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 164757009343 NodB motif; other site 164757009344 putative active site [active] 164757009345 putative catalytic site [active] 164757009346 putative Zn binding site [ion binding]; other site 164757009347 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 164757009348 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 164757009349 DXD motif; other site 164757009350 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 164757009351 putative sugar binding site [chemical binding]; other site 164757009352 catalytic residues [active] 164757009353 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 164757009354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 164757009355 putative dimer interface [polypeptide binding]; other site 164757009356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757009357 ligand binding site [chemical binding]; other site 164757009358 Zn binding site [ion binding]; other site 164757009359 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757009360 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 164757009361 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 164757009362 dimer interface [polypeptide binding]; other site 164757009363 catalytic triad [active] 164757009364 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 164757009365 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 164757009366 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 164757009367 dimer interface [polypeptide binding]; other site 164757009368 TPP-binding site [chemical binding]; other site 164757009369 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 164757009370 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 164757009371 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757009372 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 164757009373 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757009374 acyl carrier protein; Provisional; Region: acpP; PRK00982 164757009375 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 164757009376 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 164757009377 dimer interface [polypeptide binding]; other site 164757009378 active site 164757009379 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 164757009380 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 164757009381 dimer interface [polypeptide binding]; other site 164757009382 active site 164757009383 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757009384 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757009385 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757009386 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757009387 Ligand Binding Site [chemical binding]; other site 164757009388 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 164757009389 Spore germination protein; Region: Spore_permease; cl17796 164757009390 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 164757009391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757009392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757009393 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 164757009394 FAD binding domain; Region: FAD_binding_4; pfam01565 164757009395 diacylglycerol kinase; Reviewed; Region: PRK11914 164757009396 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 164757009397 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 164757009398 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757009399 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757009400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 164757009401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757009402 S-adenosylmethionine binding site [chemical binding]; other site 164757009403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757009404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757009405 DNA binding residues [nucleotide binding] 164757009406 dimerization interface [polypeptide binding]; other site 164757009407 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 164757009408 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757009409 NAD binding site [chemical binding]; other site 164757009410 catalytic Zn binding site [ion binding]; other site 164757009411 substrate binding site [chemical binding]; other site 164757009412 structural Zn binding site [ion binding]; other site 164757009413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757009414 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 164757009415 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 164757009416 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 164757009417 conserved cys residue [active] 164757009418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757009419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757009420 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 164757009421 DJ-1 family protein; Region: not_thiJ; TIGR01383 164757009422 conserved cys residue [active] 164757009423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757009424 nucleotide binding site [chemical binding]; other site 164757009425 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757009426 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757009427 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 164757009428 classical (c) SDRs; Region: SDR_c; cd05233 164757009429 NAD(P) binding site [chemical binding]; other site 164757009430 active site 164757009431 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 164757009432 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 164757009433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 164757009434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757009435 dimer interface [polypeptide binding]; other site 164757009436 conserved gate region; other site 164757009437 putative PBP binding loops; other site 164757009438 ABC-ATPase subunit interface; other site 164757009439 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 164757009440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757009441 putative PBP binding loops; other site 164757009442 dimer interface [polypeptide binding]; other site 164757009443 ABC-ATPase subunit interface; other site 164757009444 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 164757009445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757009446 Walker A/P-loop; other site 164757009447 ATP binding site [chemical binding]; other site 164757009448 Q-loop/lid; other site 164757009449 ABC transporter signature motif; other site 164757009450 Walker B; other site 164757009451 D-loop; other site 164757009452 H-loop/switch region; other site 164757009453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 164757009454 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757009455 Walker A/P-loop; other site 164757009456 ATP binding site [chemical binding]; other site 164757009457 Q-loop/lid; other site 164757009458 ABC transporter signature motif; other site 164757009459 Walker B; other site 164757009460 D-loop; other site 164757009461 H-loop/switch region; other site 164757009462 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757009463 classical (c) SDRs; Region: SDR_c; cd05233 164757009464 NAD(P) binding site [chemical binding]; other site 164757009465 active site 164757009466 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 164757009467 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757009468 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757009469 active site 164757009470 ATP binding site [chemical binding]; other site 164757009471 substrate binding site [chemical binding]; other site 164757009472 activation loop (A-loop); other site 164757009473 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 164757009474 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 164757009475 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 164757009476 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 164757009477 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 164757009478 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 164757009479 RNA binding site [nucleotide binding]; other site 164757009480 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 164757009481 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 164757009482 NAD binding site [chemical binding]; other site 164757009483 substrate binding site [chemical binding]; other site 164757009484 catalytic Zn binding site [ion binding]; other site 164757009485 structural Zn binding site [ion binding]; other site 164757009486 phosphoenolpyruvate synthase; Validated; Region: PRK06464 164757009487 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 164757009488 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 164757009489 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 164757009490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757009491 active site 164757009492 motif I; other site 164757009493 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 164757009494 motif II; other site 164757009495 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 164757009496 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 164757009497 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 164757009498 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 164757009499 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 164757009500 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 164757009501 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757009502 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757009503 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757009504 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757009505 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757009506 dimer interface [polypeptide binding]; other site 164757009507 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757009508 Ligand Binding Site [chemical binding]; other site 164757009509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757009510 Ligand Binding Site [chemical binding]; other site 164757009511 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 164757009512 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 164757009513 putative substrate binding site [chemical binding]; other site 164757009514 putative ATP binding site [chemical binding]; other site 164757009515 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 164757009516 active site 164757009517 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 164757009518 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 164757009519 active site 164757009520 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 164757009521 nickel binding site [ion binding]; other site 164757009522 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 164757009523 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 164757009524 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 164757009525 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 164757009526 FAD binding pocket [chemical binding]; other site 164757009527 FAD binding motif [chemical binding]; other site 164757009528 phosphate binding motif [ion binding]; other site 164757009529 beta-alpha-beta structure motif; other site 164757009530 NAD binding pocket [chemical binding]; other site 164757009531 Iron coordination center [ion binding]; other site 164757009532 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 164757009533 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 164757009534 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 164757009535 N-acetyl-D-glucosamine binding site [chemical binding]; other site 164757009536 catalytic residue [active] 164757009537 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 164757009538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757009539 Cytochrome P450; Region: p450; cl12078 164757009540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757009541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757009542 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 164757009543 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757009544 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 164757009545 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 164757009546 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 164757009547 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757009548 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 164757009549 Walker A/P-loop; other site 164757009550 ATP binding site [chemical binding]; other site 164757009551 Q-loop/lid; other site 164757009552 ABC transporter signature motif; other site 164757009553 Walker B; other site 164757009554 D-loop; other site 164757009555 H-loop/switch region; other site 164757009556 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757009557 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757009558 Walker A/P-loop; other site 164757009559 ATP binding site [chemical binding]; other site 164757009560 Q-loop/lid; other site 164757009561 ABC transporter signature motif; other site 164757009562 Walker B; other site 164757009563 D-loop; other site 164757009564 H-loop/switch region; other site 164757009565 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757009566 MarR family; Region: MarR; pfam01047 164757009567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757009568 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757009569 putative substrate translocation pore; other site 164757009570 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 164757009571 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757009572 active site 164757009573 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 164757009574 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 164757009575 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 164757009576 D-pathway; other site 164757009577 Putative ubiquinol binding site [chemical binding]; other site 164757009578 Low-spin heme (heme b) binding site [chemical binding]; other site 164757009579 Putative water exit pathway; other site 164757009580 Binuclear center (heme o3/CuB) [ion binding]; other site 164757009581 K-pathway; other site 164757009582 Putative proton exit pathway; other site 164757009583 The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918 164757009584 DNA primase; Validated; Region: dnaG; PRK05667 164757009585 CHC2 zinc finger; Region: zf-CHC2; cl17510 164757009586 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 164757009587 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 164757009588 active site 164757009589 metal binding site [ion binding]; metal-binding site 164757009590 interdomain interaction site; other site 164757009591 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 164757009592 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 164757009593 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 164757009594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757009595 Zn2+ binding site [ion binding]; other site 164757009596 Mg2+ binding site [ion binding]; other site 164757009597 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 164757009598 Repair protein; Region: Repair_PSII; pfam04536 164757009599 glycyl-tRNA synthetase; Provisional; Region: PRK04173 164757009600 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 164757009601 motif 1; other site 164757009602 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 164757009603 active site 164757009604 motif 2; other site 164757009605 motif 3; other site 164757009606 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 164757009607 anticodon binding site; other site 164757009608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757009609 dimerization interface [polypeptide binding]; other site 164757009610 putative DNA binding site [nucleotide binding]; other site 164757009611 putative Zn2+ binding site [ion binding]; other site 164757009612 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 164757009613 metal binding site 2 [ion binding]; metal-binding site 164757009614 putative DNA binding helix; other site 164757009615 metal binding site 1 [ion binding]; metal-binding site 164757009616 dimer interface [polypeptide binding]; other site 164757009617 structural Zn2+ binding site [ion binding]; other site 164757009618 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 164757009619 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 164757009620 catalytic residue [active] 164757009621 putative FPP diphosphate binding site; other site 164757009622 putative FPP binding hydrophobic cleft; other site 164757009623 dimer interface [polypeptide binding]; other site 164757009624 putative IPP diphosphate binding site; other site 164757009625 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 164757009626 Recombination protein O N terminal; Region: RecO_N; pfam11967 164757009627 Recombination protein O C terminal; Region: RecO_C; pfam02565 164757009628 amidase; Provisional; Region: PRK06061 164757009629 Amidase; Region: Amidase; pfam01425 164757009630 GTPase Era; Reviewed; Region: era; PRK00089 164757009631 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 164757009632 G1 box; other site 164757009633 GTP/Mg2+ binding site [chemical binding]; other site 164757009634 Switch I region; other site 164757009635 G2 box; other site 164757009636 Switch II region; other site 164757009637 G3 box; other site 164757009638 G4 box; other site 164757009639 G5 box; other site 164757009640 KH domain; Region: KH_2; pfam07650 164757009641 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 164757009642 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757009643 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757009644 Transporter associated domain; Region: CorC_HlyC; smart01091 164757009645 metal-binding heat shock protein; Provisional; Region: PRK00016 164757009646 K homology RNA-binding domain; Region: KH; smart00322 164757009647 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 164757009648 PhoH-like protein; Region: PhoH; pfam02562 164757009649 Protein of unknown function (DUF998); Region: DUF998; pfam06197 164757009650 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 164757009651 chaperone protein DnaJ; Provisional; Region: PRK14278 164757009652 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 164757009653 HSP70 interaction site [polypeptide binding]; other site 164757009654 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 164757009655 Zn binding sites [ion binding]; other site 164757009656 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 164757009657 dimer interface [polypeptide binding]; other site 164757009658 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 164757009659 HTH domain; Region: HTH_11; cl17392 164757009660 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 164757009661 MbtH-like protein; Region: MbtH; pfam03621 164757009662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757009663 Condensation domain; Region: Condensation; pfam00668 164757009664 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 164757009665 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 164757009666 acyl-activating enzyme (AAE) consensus motif; other site 164757009667 AMP binding site [chemical binding]; other site 164757009668 Condensation domain; Region: Condensation; pfam00668 164757009669 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 164757009670 Condensation domain; Region: Condensation; pfam00668 164757009671 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 164757009672 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 164757009673 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 164757009674 acyl-activating enzyme (AAE) consensus motif; other site 164757009675 AMP binding site [chemical binding]; other site 164757009676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757009677 Condensation domain; Region: Condensation; pfam00668 164757009678 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 164757009679 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 164757009680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757009681 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757009682 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757009683 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 164757009684 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 164757009685 NADP binding site [chemical binding]; other site 164757009686 active site 164757009687 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757009688 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757009689 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757009690 active site 164757009691 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 164757009692 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 164757009693 Condensation domain; Region: Condensation; pfam00668 164757009694 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 164757009695 Nonribosomal peptide synthase; Region: NRPS; pfam08415 164757009696 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 164757009697 acyl-activating enzyme (AAE) consensus motif; other site 164757009698 AMP binding site [chemical binding]; other site 164757009699 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757009700 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 164757009701 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 164757009702 acyl-activating enzyme (AAE) consensus motif; other site 164757009703 active site 164757009704 AMP binding site [chemical binding]; other site 164757009705 substrate binding site [chemical binding]; other site 164757009706 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757009707 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757009708 active site 164757009709 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 164757009710 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757009711 active site 164757009712 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757009713 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 164757009714 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 164757009715 KR domain; Region: KR; pfam08659 164757009716 putative NADP binding site [chemical binding]; other site 164757009717 active site 164757009718 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757009719 coproporphyrinogen III oxidase; Validated; Region: PRK05628 164757009720 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 164757009721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757009722 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 164757009723 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 164757009724 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 164757009725 Active Sites [active] 164757009726 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 164757009727 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 164757009728 putative active site [active] 164757009729 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 164757009730 putative active site [active] 164757009731 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757009732 FOG: CBS domain [General function prediction only]; Region: COG0517 164757009733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757009734 Transporter associated domain; Region: CorC_HlyC; pfam03471 164757009735 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 164757009736 Domain of unknown function DUF21; Region: DUF21; pfam01595 164757009737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 164757009738 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 164757009739 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 164757009740 Walker A/P-loop; other site 164757009741 ATP binding site [chemical binding]; other site 164757009742 Q-loop/lid; other site 164757009743 ABC transporter signature motif; other site 164757009744 Walker B; other site 164757009745 D-loop; other site 164757009746 H-loop/switch region; other site 164757009747 TOBE-like domain; Region: TOBE_3; pfam12857 164757009748 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 164757009749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757009750 dimer interface [polypeptide binding]; other site 164757009751 conserved gate region; other site 164757009752 putative PBP binding loops; other site 164757009753 ABC-ATPase subunit interface; other site 164757009754 sulfate transport protein; Provisional; Region: cysT; CHL00187 164757009755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757009756 dimer interface [polypeptide binding]; other site 164757009757 conserved gate region; other site 164757009758 putative PBP binding loops; other site 164757009759 ABC-ATPase subunit interface; other site 164757009760 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 164757009761 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 164757009762 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 164757009763 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 164757009764 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757009765 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 164757009766 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 164757009767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757009768 active site 164757009769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757009770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757009771 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 164757009772 putative dimerization interface [polypeptide binding]; other site 164757009773 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 164757009774 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 164757009775 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 164757009776 PknH-like extracellular domain; Region: PknH_C; pfam14032 164757009777 PknH-like extracellular domain; Region: PknH_C; pfam14032 164757009778 GTP-binding protein LepA; Provisional; Region: PRK05433 164757009779 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 164757009780 G1 box; other site 164757009781 putative GEF interaction site [polypeptide binding]; other site 164757009782 GTP/Mg2+ binding site [chemical binding]; other site 164757009783 Switch I region; other site 164757009784 G2 box; other site 164757009785 G3 box; other site 164757009786 Switch II region; other site 164757009787 G4 box; other site 164757009788 G5 box; other site 164757009789 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 164757009790 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 164757009791 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 164757009792 PemK-like protein; Region: PemK; pfam02452 164757009793 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 164757009794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 164757009795 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 164757009796 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 164757009797 active site 164757009798 dimer interface [polypeptide binding]; other site 164757009799 non-prolyl cis peptide bond; other site 164757009800 insertion regions; other site 164757009801 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757009802 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 164757009803 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 164757009804 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 164757009805 Walker A/P-loop; other site 164757009806 ATP binding site [chemical binding]; other site 164757009807 Q-loop/lid; other site 164757009808 ABC transporter signature motif; other site 164757009809 Walker B; other site 164757009810 D-loop; other site 164757009811 H-loop/switch region; other site 164757009812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757009813 dimer interface [polypeptide binding]; other site 164757009814 conserved gate region; other site 164757009815 ABC-ATPase subunit interface; other site 164757009816 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 164757009817 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 164757009818 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 164757009819 active site 164757009820 non-prolyl cis peptide bond; other site 164757009821 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 164757009822 ribonuclease Z; Reviewed; Region: PRK00055 164757009823 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 164757009824 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 164757009825 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 164757009826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 164757009827 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 164757009828 Uncharacterized conserved protein [Function unknown]; Region: COG2308 164757009829 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 164757009830 hypothetical protein; Reviewed; Region: PRK07914 164757009831 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 164757009832 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 164757009833 Competence protein; Region: Competence; pfam03772 164757009834 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 164757009835 SLBB domain; Region: SLBB; pfam10531 164757009836 Helix-hairpin-helix motif; Region: HHH; pfam00633 164757009837 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 164757009838 homotrimer interaction site [polypeptide binding]; other site 164757009839 putative active site [active] 164757009840 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757009841 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757009842 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757009843 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757009844 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 164757009845 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 164757009846 putative hydrophobic ligand binding site [chemical binding]; other site 164757009847 CLM binding site; other site 164757009848 L1 loop; other site 164757009849 DNA binding site [nucleotide binding] 164757009850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757009851 putative DNA binding site [nucleotide binding]; other site 164757009852 putative Zn2+ binding site [ion binding]; other site 164757009853 EDD domain protein, DegV family; Region: DegV; TIGR00762 164757009854 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 164757009855 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 164757009856 active site 164757009857 catalytic triad [active] 164757009858 oxyanion hole [active] 164757009859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757009860 catalytic core [active] 164757009861 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 164757009862 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 164757009863 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 164757009864 active site 164757009865 (T/H)XGH motif; other site 164757009866 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 164757009867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757009868 DNA-binding site [nucleotide binding]; DNA binding site 164757009869 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 164757009870 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 164757009871 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 164757009872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757009873 nucleotide binding site [chemical binding]; other site 164757009874 Predicted dehydrogenase [General function prediction only]; Region: COG0579 164757009875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 164757009876 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 164757009877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757009878 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 164757009879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 164757009880 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 164757009881 metal ion-dependent adhesion site (MIDAS); other site 164757009882 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757009883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757009884 Walker A motif; other site 164757009885 ATP binding site [chemical binding]; other site 164757009886 Walker B motif; other site 164757009887 arginine finger; other site 164757009888 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 164757009889 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 164757009890 putative catalytic cysteine [active] 164757009891 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 164757009892 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 164757009893 substrate binding site [chemical binding]; other site 164757009894 dimer interface [polypeptide binding]; other site 164757009895 ATP binding site [chemical binding]; other site 164757009896 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757009897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757009898 substrate binding site [chemical binding]; other site 164757009899 oxyanion hole (OAH) forming residues; other site 164757009900 trimer interface [polypeptide binding]; other site 164757009901 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757009902 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757009903 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757009904 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757009905 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757009906 active site 164757009907 NAD synthetase; Reviewed; Region: nadE; PRK02628 164757009908 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 164757009909 multimer interface [polypeptide binding]; other site 164757009910 active site 164757009911 catalytic triad [active] 164757009912 protein interface 1 [polypeptide binding]; other site 164757009913 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 164757009914 homodimer interface [polypeptide binding]; other site 164757009915 NAD binding pocket [chemical binding]; other site 164757009916 ATP binding pocket [chemical binding]; other site 164757009917 Mg binding site [ion binding]; other site 164757009918 active-site loop [active] 164757009919 Isochorismatase family; Region: Isochorismatase; pfam00857 164757009920 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 164757009921 catalytic triad [active] 164757009922 conserved cis-peptide bond; other site 164757009923 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 164757009924 NAD-dependent deacetylase; Provisional; Region: PRK05333 164757009925 NAD+ binding site [chemical binding]; other site 164757009926 substrate binding site [chemical binding]; other site 164757009927 Zn binding site [ion binding]; other site 164757009928 gamma-glutamyl kinase; Provisional; Region: PRK05429 164757009929 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 164757009930 nucleotide binding site [chemical binding]; other site 164757009931 homotetrameric interface [polypeptide binding]; other site 164757009932 putative phosphate binding site [ion binding]; other site 164757009933 putative allosteric binding site; other site 164757009934 PUA domain; Region: PUA; pfam01472 164757009935 GTPase CgtA; Reviewed; Region: obgE; PRK12296 164757009936 GTP1/OBG; Region: GTP1_OBG; pfam01018 164757009937 Obg GTPase; Region: Obg; cd01898 164757009938 G1 box; other site 164757009939 GTP/Mg2+ binding site [chemical binding]; other site 164757009940 Switch I region; other site 164757009941 G2 box; other site 164757009942 G3 box; other site 164757009943 Switch II region; other site 164757009944 G4 box; other site 164757009945 G5 box; other site 164757009946 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 164757009947 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 164757009948 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 164757009949 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 164757009950 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 164757009951 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 164757009952 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 164757009953 homodimer interface [polypeptide binding]; other site 164757009954 oligonucleotide binding site [chemical binding]; other site 164757009955 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 164757009956 active site 164757009957 multimer interface [polypeptide binding]; other site 164757009958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757009959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757009960 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 164757009961 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 164757009962 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 164757009963 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 164757009964 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 164757009965 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 164757009966 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 164757009967 active site 164757009968 HIGH motif; other site 164757009969 nucleotide binding site [chemical binding]; other site 164757009970 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 164757009971 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 164757009972 active site 164757009973 KMSKS motif; other site 164757009974 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 164757009975 tRNA binding surface [nucleotide binding]; other site 164757009976 anticodon binding site; other site 164757009977 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 164757009978 Uncharacterized conserved protein [Function unknown]; Region: COG3268 164757009979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757009980 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 164757009981 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 164757009982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757009983 hypothetical protein; Provisional; Region: PRK06753 164757009984 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757009985 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757009986 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757009987 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 164757009988 GTP binding site; other site 164757009989 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 164757009990 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 164757009991 TPP-binding site [chemical binding]; other site 164757009992 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 164757009993 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 164757009994 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 164757009995 dimer interface [polypeptide binding]; other site 164757009996 PYR/PP interface [polypeptide binding]; other site 164757009997 TPP binding site [chemical binding]; other site 164757009998 substrate binding site [chemical binding]; other site 164757009999 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757010000 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757010001 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757010002 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757010003 [2Fe-2S] cluster binding site [ion binding]; other site 164757010004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 164757010005 Uncharacterized conserved protein [Function unknown]; Region: COG3391 164757010006 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 164757010007 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 164757010008 active site 164757010009 TDP-binding site; other site 164757010010 acceptor substrate-binding pocket; other site 164757010011 homodimer interface [polypeptide binding]; other site 164757010012 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 164757010013 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 164757010014 iron-sulfur cluster [ion binding]; other site 164757010015 [2Fe-2S] cluster binding site [ion binding]; other site 164757010016 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 164757010017 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 164757010018 putative di-iron ligands [ion binding]; other site 164757010019 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 164757010020 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 164757010021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757010022 Walker A motif; other site 164757010023 ATP binding site [chemical binding]; other site 164757010024 Walker B motif; other site 164757010025 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 164757010026 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 164757010027 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 164757010028 oligomer interface [polypeptide binding]; other site 164757010029 active site residues [active] 164757010030 Clp protease; Region: CLP_protease; pfam00574 164757010031 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 164757010032 oligomer interface [polypeptide binding]; other site 164757010033 active site residues [active] 164757010034 trigger factor; Provisional; Region: tig; PRK01490 164757010035 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 164757010036 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 164757010037 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 164757010038 hypothetical protein; Provisional; Region: PRK07208 164757010039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757010040 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 164757010041 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 164757010042 catalytic residue [active] 164757010043 putative FPP diphosphate binding site; other site 164757010044 putative FPP binding hydrophobic cleft; other site 164757010045 dimer interface [polypeptide binding]; other site 164757010046 putative IPP diphosphate binding site; other site 164757010047 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 164757010048 Bacterial sugar transferase; Region: Bac_transf; pfam02397 164757010049 GAF domain; Region: GAF; pfam01590 164757010050 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757010051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757010052 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 164757010053 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 164757010054 Right handed beta helix region; Region: Beta_helix; pfam13229 164757010055 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 164757010056 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 164757010057 putative ADP-binding pocket [chemical binding]; other site 164757010058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757010059 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 164757010060 FHIPEP family; Region: FHIPEP; cl07980 164757010061 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 164757010062 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 164757010063 putative [4Fe-4S] binding site [ion binding]; other site 164757010064 putative molybdopterin cofactor binding site [chemical binding]; other site 164757010065 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 164757010066 molybdopterin cofactor binding site; other site 164757010067 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757010068 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757010069 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 164757010070 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 164757010071 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 164757010072 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 164757010073 putative DNA binding site [nucleotide binding]; other site 164757010074 catalytic residue [active] 164757010075 putative H2TH interface [polypeptide binding]; other site 164757010076 putative catalytic residues [active] 164757010077 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 164757010078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 164757010079 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 164757010080 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 164757010081 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 164757010082 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 164757010083 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 164757010084 nucleoside/Zn binding site; other site 164757010085 dimer interface [polypeptide binding]; other site 164757010086 catalytic motif [active] 164757010087 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 164757010088 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 164757010089 acyl-activating enzyme (AAE) consensus motif; other site 164757010090 putative AMP binding site [chemical binding]; other site 164757010091 putative active site [active] 164757010092 putative CoA binding site [chemical binding]; other site 164757010093 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 164757010094 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 164757010095 catalytic residues [active] 164757010096 N-formylglutamate amidohydrolase; Region: FGase; cl01522 164757010097 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757010098 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 164757010099 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 164757010100 Zn binding site [ion binding]; other site 164757010101 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757010102 active site 164757010103 Domain of unknown function (DUF477); Region: DUF477; cl01535 164757010104 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 164757010105 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757010106 active site 164757010107 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 164757010108 apolar tunnel; other site 164757010109 heme binding site [chemical binding]; other site 164757010110 dimerization interface [polypeptide binding]; other site 164757010111 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 164757010112 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 164757010113 active site 164757010114 catalytic site [active] 164757010115 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 164757010116 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 164757010117 active site 164757010118 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 164757010119 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 164757010120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757010121 Walker A/P-loop; other site 164757010122 ATP binding site [chemical binding]; other site 164757010123 Q-loop/lid; other site 164757010124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757010125 ABC transporter; Region: ABC_tran_2; pfam12848 164757010126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757010127 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 164757010128 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 164757010129 dimer interface [polypeptide binding]; other site 164757010130 ssDNA binding site [nucleotide binding]; other site 164757010131 tetramer (dimer of dimers) interface [polypeptide binding]; other site 164757010132 Copper resistance protein D; Region: CopD; pfam05425 164757010133 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 164757010134 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 164757010135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 164757010136 putative acyl-acceptor binding pocket; other site 164757010137 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 164757010138 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 164757010139 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757010140 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 164757010141 putative acyl-acceptor binding pocket; other site 164757010142 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757010143 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757010144 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757010145 Ligand Binding Site [chemical binding]; other site 164757010146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757010147 Ligand Binding Site [chemical binding]; other site 164757010148 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 164757010149 enoyl-CoA hydratase; Provisional; Region: PRK05870 164757010150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757010151 substrate binding site [chemical binding]; other site 164757010152 oxyanion hole (OAH) forming residues; other site 164757010153 trimer interface [polypeptide binding]; other site 164757010154 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 164757010155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 164757010156 E3 interaction surface; other site 164757010157 lipoyl attachment site [posttranslational modification]; other site 164757010158 e3 binding domain; Region: E3_binding; pfam02817 164757010159 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 164757010160 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 164757010161 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 164757010162 alpha subunit interface [polypeptide binding]; other site 164757010163 TPP binding site [chemical binding]; other site 164757010164 heterodimer interface [polypeptide binding]; other site 164757010165 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 164757010166 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 164757010167 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 164757010168 tetramer interface [polypeptide binding]; other site 164757010169 TPP-binding site [chemical binding]; other site 164757010170 heterodimer interface [polypeptide binding]; other site 164757010171 phosphorylation loop region [posttranslational modification] 164757010172 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 164757010173 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 164757010174 putative active site [active] 164757010175 putative catalytic site [active] 164757010176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010178 active site 164757010179 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 164757010180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757010181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 164757010182 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 164757010183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757010184 carboxyltransferase (CT) interaction site; other site 164757010185 biotinylation site [posttranslational modification]; other site 164757010186 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 164757010187 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757010188 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757010189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010191 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757010192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757010193 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 164757010194 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 164757010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010196 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757010197 classical (c) SDRs; Region: SDR_c; cd05233 164757010198 NAD(P) binding site [chemical binding]; other site 164757010199 active site 164757010200 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 164757010201 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 164757010202 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 164757010203 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 164757010204 catalytic site [active] 164757010205 putative active site [active] 164757010206 putative substrate binding site [chemical binding]; other site 164757010207 dimer interface [polypeptide binding]; other site 164757010208 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757010209 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 164757010210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757010211 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757010212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757010213 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757010214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757010215 DNA binding site [nucleotide binding] 164757010216 active site 164757010217 Int/Topo IB signature motif; other site 164757010218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 164757010219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 164757010220 catalytic residues [active] 164757010221 catalytic nucleophile [active] 164757010222 Recombinase; Region: Recombinase; pfam07508 164757010223 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 164757010224 polymerase nucleotide-binding site; other site 164757010225 DNA-binding residues [nucleotide binding]; DNA binding site 164757010226 nucleotide binding site [chemical binding]; other site 164757010227 primase nucleotide-binding site [nucleotide binding]; other site 164757010228 AAA domain; Region: AAA_25; pfam13481 164757010229 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 164757010230 ATP binding site [chemical binding]; other site 164757010231 Walker B motif; other site 164757010232 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 164757010233 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 164757010234 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757010235 catalytic triad [active] 164757010236 hypothetical protein; Provisional; Region: PRK07907 164757010237 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 164757010238 active site 164757010239 metal binding site [ion binding]; metal-binding site 164757010240 dimer interface [polypeptide binding]; other site 164757010241 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 164757010242 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 164757010243 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 164757010244 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 164757010245 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 164757010246 phosphate binding site [ion binding]; other site 164757010247 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 164757010248 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 164757010249 putative active site [active] 164757010250 putative catalytic site [active] 164757010251 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 164757010252 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757010253 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 164757010254 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 164757010255 putative NAD(P) binding site [chemical binding]; other site 164757010256 active site 164757010257 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 164757010258 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 164757010259 active site 164757010260 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 164757010261 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 164757010262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757010263 DNA binding residues [nucleotide binding] 164757010264 putative dimer interface [polypeptide binding]; other site 164757010265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757010267 putative substrate translocation pore; other site 164757010268 ChaB; Region: ChaB; pfam06150 164757010269 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 164757010270 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 164757010271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010272 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 164757010273 acyl-activating enzyme (AAE) consensus motif; other site 164757010274 acyl-activating enzyme (AAE) consensus motif; other site 164757010275 putative AMP binding site [chemical binding]; other site 164757010276 putative active site [active] 164757010277 putative CoA binding site [chemical binding]; other site 164757010278 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757010279 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 164757010280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010281 acyl-activating enzyme (AAE) consensus motif; other site 164757010282 AMP binding site [chemical binding]; other site 164757010283 active site 164757010284 CoA binding site [chemical binding]; other site 164757010285 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757010286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757010287 substrate binding site [chemical binding]; other site 164757010288 oxyanion hole (OAH) forming residues; other site 164757010289 trimer interface [polypeptide binding]; other site 164757010290 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757010291 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757010292 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 164757010293 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757010294 active site 164757010295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010298 Cytochrome P450; Region: p450; cl12078 164757010299 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757010300 mce related protein; Region: MCE; pfam02470 164757010301 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757010302 mce related protein; Region: MCE; pfam02470 164757010303 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757010304 mce related protein; Region: MCE; pfam02470 164757010305 mce related protein; Region: MCE; pfam02470 164757010306 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757010307 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757010308 mce related protein; Region: MCE; pfam02470 164757010309 mce related protein; Region: MCE; pfam02470 164757010310 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757010311 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757010312 Permease; Region: Permease; pfam02405 164757010313 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757010314 Permease; Region: Permease; pfam02405 164757010315 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757010316 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757010317 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757010318 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757010319 NAD binding site [chemical binding]; other site 164757010320 catalytic residues [active] 164757010321 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757010322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010323 NAD(P) binding site [chemical binding]; other site 164757010324 active site 164757010325 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757010326 classical (c) SDRs; Region: SDR_c; cd05233 164757010327 NAD(P) binding site [chemical binding]; other site 164757010328 active site 164757010329 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 164757010330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010331 Cytochrome P450; Region: p450; cl12078 164757010332 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010334 active site 164757010335 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010336 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757010337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010338 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757010339 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757010340 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757010341 iron-sulfur cluster [ion binding]; other site 164757010342 [2Fe-2S] cluster binding site [ion binding]; other site 164757010343 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757010344 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 164757010345 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 164757010346 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 164757010347 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757010348 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757010349 lipid-transfer protein; Provisional; Region: PRK07855 164757010350 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757010351 active site 164757010352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757010353 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757010354 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 164757010355 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757010356 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 164757010357 Cytochrome P450; Region: p450; cl12078 164757010358 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010359 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757010360 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757010361 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010362 Cytochrome P450; Region: p450; cl12078 164757010363 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 164757010364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757010365 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757010366 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757010367 [2Fe-2S] cluster binding site [ion binding]; other site 164757010368 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 164757010369 putative alpha subunit interface [polypeptide binding]; other site 164757010370 putative active site [active] 164757010371 putative substrate binding site [chemical binding]; other site 164757010372 Fe binding site [ion binding]; other site 164757010373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010375 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 164757010376 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757010377 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757010378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010379 Cytochrome P450; Region: p450; cl12078 164757010380 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757010381 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757010382 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 164757010383 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 164757010384 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757010385 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757010386 [2Fe-2S] cluster binding site [ion binding]; other site 164757010387 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 164757010388 alpha subunit interface [polypeptide binding]; other site 164757010389 active site 164757010390 substrate binding site [chemical binding]; other site 164757010391 Fe binding site [ion binding]; other site 164757010392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757010393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010394 NAD(P) binding site [chemical binding]; other site 164757010395 active site 164757010396 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 164757010397 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 164757010398 FAD binding pocket [chemical binding]; other site 164757010399 FAD binding motif [chemical binding]; other site 164757010400 phosphate binding motif [ion binding]; other site 164757010401 beta-alpha-beta structure motif; other site 164757010402 NAD(p) ribose binding residues [chemical binding]; other site 164757010403 NAD binding pocket [chemical binding]; other site 164757010404 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 164757010405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757010406 catalytic loop [active] 164757010407 iron binding site [ion binding]; other site 164757010408 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757010409 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 164757010410 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757010411 MarR family; Region: MarR_2; pfam12802 164757010412 MarR family; Region: MarR_2; cl17246 164757010413 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757010414 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 164757010415 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 164757010416 active site 164757010417 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757010418 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757010419 [2Fe-2S] cluster binding site [ion binding]; other site 164757010420 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 164757010421 alpha subunit interface [polypeptide binding]; other site 164757010422 active site 164757010423 substrate binding site [chemical binding]; other site 164757010424 Fe binding site [ion binding]; other site 164757010425 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 164757010426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757010427 NAD binding site [chemical binding]; other site 164757010428 catalytic residues [active] 164757010429 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010430 Cytochrome P450; Region: p450; cl12078 164757010431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757010436 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757010437 Walker A motif; other site 164757010438 ATP binding site [chemical binding]; other site 164757010439 Walker B motif; other site 164757010440 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 164757010441 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 164757010442 metal ion-dependent adhesion site (MIDAS); other site 164757010443 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757010444 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757010445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010446 NAD(P) binding site [chemical binding]; other site 164757010447 active site 164757010448 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 164757010449 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757010450 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757010451 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757010452 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757010453 active site 164757010454 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 164757010455 dimer interface [polypeptide binding]; other site 164757010456 substrate binding site [chemical binding]; other site 164757010457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010461 active site 164757010462 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757010463 putative active site [active] 164757010464 putative substrate binding site [chemical binding]; other site 164757010465 ATP binding site [chemical binding]; other site 164757010466 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 164757010467 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757010468 NAD(P) binding site [chemical binding]; other site 164757010469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010473 active site 164757010474 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 164757010475 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757010476 dimer interface [polypeptide binding]; other site 164757010477 active site 164757010478 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757010479 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757010480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010481 NAD(P) binding site [chemical binding]; other site 164757010482 active site 164757010483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010485 active site 164757010486 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757010487 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757010488 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757010489 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757010490 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757010491 [2Fe-2S] cluster binding site [ion binding]; other site 164757010492 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 164757010493 alpha subunit interface [polypeptide binding]; other site 164757010494 active site 164757010495 substrate binding site [chemical binding]; other site 164757010496 Fe binding site [ion binding]; other site 164757010497 Herpesvirus VP23 like capsid protein; Region: Herpes_V23; cl17653 164757010498 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 164757010499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757010500 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 164757010501 active site 164757010502 SnoaL-like domain; Region: SnoaL_4; pfam13577 164757010503 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 164757010504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010505 active site 164757010506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010508 enoyl-CoA hydratase; Provisional; Region: PRK08290 164757010509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757010510 substrate binding site [chemical binding]; other site 164757010511 oxyanion hole (OAH) forming residues; other site 164757010512 trimer interface [polypeptide binding]; other site 164757010513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010515 active site 164757010516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010518 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757010519 classical (c) SDRs; Region: SDR_c; cd05233 164757010520 NAD(P) binding site [chemical binding]; other site 164757010521 active site 164757010522 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757010523 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757010524 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757010525 acyl-CoA synthetase; Provisional; Region: PRK13382 164757010526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010527 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010528 acyl-activating enzyme (AAE) consensus motif; other site 164757010529 AMP binding site [chemical binding]; other site 164757010530 active site 164757010531 CoA binding site [chemical binding]; other site 164757010532 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757010533 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757010534 putative acyl-acceptor binding pocket; other site 164757010535 extended (e) SDRs; Region: SDR_e; cd08946 164757010536 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 164757010537 NAD(P) binding site [chemical binding]; other site 164757010538 active site 164757010539 substrate binding site [chemical binding]; other site 164757010540 classical (c) SDRs; Region: SDR_c; cd05233 164757010541 NAD(P) binding site [chemical binding]; other site 164757010542 active site 164757010543 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757010544 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757010545 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757010546 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757010547 enoyl-CoA hydratase; Provisional; Region: PRK12478 164757010548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757010549 substrate binding site [chemical binding]; other site 164757010550 oxyanion hole (OAH) forming residues; other site 164757010551 trimer interface [polypeptide binding]; other site 164757010552 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 164757010553 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 164757010554 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 164757010555 active site 164757010556 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 164757010557 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 164757010558 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 164757010559 active site 164757010560 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757010561 Cytochrome P450; Region: p450; cl12078 164757010562 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010563 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757010564 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 164757010565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 164757010569 NAD(P) binding site [chemical binding]; other site 164757010570 active site 164757010571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757010572 TAP-like protein; Region: Abhydrolase_4; pfam08386 164757010573 Predicted flavoprotein [General function prediction only]; Region: COG0431 164757010574 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 164757010575 Putative cyclase; Region: Cyclase; pfam04199 164757010576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757010577 NAD(P) binding site [chemical binding]; other site 164757010578 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 164757010579 active site 164757010580 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 164757010581 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 164757010582 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 164757010583 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757010584 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 164757010585 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 164757010586 active site 164757010587 metal binding site [ion binding]; metal-binding site 164757010588 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 164757010589 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757010590 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757010591 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757010592 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 164757010593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757010594 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 164757010595 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 164757010596 L-aspartate oxidase; Provisional; Region: PRK06175 164757010597 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757010598 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 164757010599 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 164757010600 Subunit I/III interface [polypeptide binding]; other site 164757010601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010602 LAO/AO transport system ATPase; Region: lao; TIGR00750 164757010603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757010604 putative acyltransferase; Provisional; Region: PRK05790 164757010605 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757010606 dimer interface [polypeptide binding]; other site 164757010607 active site 164757010608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010609 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 164757010610 NAD(P) binding site [chemical binding]; other site 164757010611 active site 164757010612 short chain dehydrogenase; Provisional; Region: PRK08278 164757010613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010614 NAD(P) binding site [chemical binding]; other site 164757010615 active site 164757010616 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757010617 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757010618 active site 164757010619 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757010620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757010621 substrate binding site [chemical binding]; other site 164757010622 oxyanion hole (OAH) forming residues; other site 164757010623 trimer interface [polypeptide binding]; other site 164757010624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010626 active site 164757010627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757010628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757010629 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757010630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010631 acyl-activating enzyme (AAE) consensus motif; other site 164757010632 AMP binding site [chemical binding]; other site 164757010633 active site 164757010634 CoA binding site [chemical binding]; other site 164757010635 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757010636 catalytic loop [active] 164757010637 iron binding site [ion binding]; other site 164757010638 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757010639 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757010640 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 164757010641 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757010642 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 164757010643 B12 binding site [chemical binding]; other site 164757010644 cobalt ligand [ion binding]; other site 164757010645 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 164757010646 short chain dehydrogenase; Provisional; Region: PRK08278 164757010647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757010648 NAD(P) binding site [chemical binding]; other site 164757010649 active site 164757010650 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757010651 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010653 acyl-activating enzyme (AAE) consensus motif; other site 164757010654 acyl-activating enzyme (AAE) consensus motif; other site 164757010655 AMP binding site [chemical binding]; other site 164757010656 active site 164757010657 CoA binding site [chemical binding]; other site 164757010658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757010659 dimerization interface [polypeptide binding]; other site 164757010660 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757010661 cyclase homology domain; Region: CHD; cd07302 164757010662 nucleotidyl binding site; other site 164757010663 metal binding site [ion binding]; metal-binding site 164757010664 dimer interface [polypeptide binding]; other site 164757010665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010666 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757010667 putative substrate translocation pore; other site 164757010668 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757010669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010670 putative substrate translocation pore; other site 164757010671 Phosphotransferase enzyme family; Region: APH; pfam01636 164757010672 Ecdysteroid kinase; Region: EcKinase; cl17738 164757010673 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757010674 Cytochrome P450; Region: p450; cl12078 164757010675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 164757010676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 164757010677 DNA binding site [nucleotide binding] 164757010678 domain linker motif; other site 164757010679 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 164757010680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010681 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757010682 putative substrate translocation pore; other site 164757010683 Domain of unknown function (DUF309); Region: DUF309; pfam03745 164757010684 Predicted membrane protein [Function unknown]; Region: COG4270 164757010685 Glucitol operon activator protein (GutM); Region: GutM; cl01890 164757010686 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 164757010687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757010688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010690 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757010691 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 164757010692 active site 164757010693 dimerization interface [polypeptide binding]; other site 164757010694 ribonuclease PH; Reviewed; Region: rph; PRK00173 164757010695 Ribonuclease PH; Region: RNase_PH_bact; cd11362 164757010696 hexamer interface [polypeptide binding]; other site 164757010697 active site 164757010698 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 164757010699 glutamate racemase; Provisional; Region: PRK00865 164757010700 Rhomboid family; Region: Rhomboid; pfam01694 164757010701 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 164757010702 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 164757010703 dimer interface [polypeptide binding]; other site 164757010704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757010705 catalytic residue [active] 164757010706 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 164757010707 MoaE interaction surface [polypeptide binding]; other site 164757010708 MoeB interaction surface [polypeptide binding]; other site 164757010709 thiocarboxylated glycine; other site 164757010710 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 164757010711 MPN+ (JAMM) motif; other site 164757010712 Zinc-binding site [ion binding]; other site 164757010713 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 164757010714 putative active site pocket [active] 164757010715 cleavage site 164757010716 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 164757010717 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 164757010718 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 164757010719 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 164757010720 active site 164757010721 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 164757010722 DEAD/DEAH box helicase; Region: DEAD; pfam00270 164757010723 DEAD_2; Region: DEAD_2; pfam06733 164757010724 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 164757010725 Predicted metalloprotease [General function prediction only]; Region: COG2321 164757010726 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 164757010727 MspA; Region: MspA; pfam09203 164757010728 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 164757010729 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 164757010730 putative homodimer interface [polypeptide binding]; other site 164757010731 putative active site pocket [active] 164757010732 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 164757010733 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 164757010734 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 164757010735 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 164757010736 active site 164757010737 homodimer interface [polypeptide binding]; other site 164757010738 catalytic site [active] 164757010739 acceptor binding site [chemical binding]; other site 164757010740 glycogen branching enzyme; Provisional; Region: PRK05402 164757010741 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 164757010742 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 164757010743 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 164757010744 active site 164757010745 catalytic site [active] 164757010746 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 164757010747 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 164757010748 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 164757010749 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 164757010750 putative acyltransferase; Provisional; Region: PRK05790 164757010751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757010752 dimer interface [polypeptide binding]; other site 164757010753 active site 164757010754 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 164757010755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757010756 dimer interface [polypeptide binding]; other site 164757010757 substrate binding site [chemical binding]; other site 164757010758 metal binding site [ion binding]; metal-binding site 164757010759 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 164757010760 hypothetical protein; Provisional; Region: PRK03298 164757010761 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 164757010762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757010763 dimerization interface [polypeptide binding]; other site 164757010764 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757010765 cyclase homology domain; Region: CHD; cd07302 164757010766 nucleotidyl binding site; other site 164757010767 metal binding site [ion binding]; metal-binding site 164757010768 dimer interface [polypeptide binding]; other site 164757010769 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 164757010770 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757010771 acyl-activating enzyme (AAE) consensus motif; other site 164757010772 active site 164757010773 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 164757010774 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 164757010775 AlkA N-terminal domain; Region: AlkA_N; pfam06029 164757010776 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 164757010777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 164757010778 minor groove reading motif; other site 164757010779 helix-hairpin-helix signature motif; other site 164757010780 substrate binding pocket [chemical binding]; other site 164757010781 active site 164757010782 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 164757010783 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 164757010784 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 164757010785 DNA binding site [nucleotide binding] 164757010786 active site 164757010787 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 164757010788 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 164757010789 hinge; other site 164757010790 active site 164757010791 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 164757010792 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 164757010793 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 164757010794 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 164757010795 gamma subunit interface [polypeptide binding]; other site 164757010796 epsilon subunit interface [polypeptide binding]; other site 164757010797 LBP interface [polypeptide binding]; other site 164757010798 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 164757010799 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 164757010800 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 164757010801 alpha subunit interaction interface [polypeptide binding]; other site 164757010802 Walker A motif; other site 164757010803 ATP binding site [chemical binding]; other site 164757010804 Walker B motif; other site 164757010805 inhibitor binding site; inhibition site 164757010806 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 164757010807 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 164757010808 core domain interface [polypeptide binding]; other site 164757010809 delta subunit interface [polypeptide binding]; other site 164757010810 epsilon subunit interface [polypeptide binding]; other site 164757010811 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 164757010812 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 164757010813 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 164757010814 beta subunit interaction interface [polypeptide binding]; other site 164757010815 Walker A motif; other site 164757010816 ATP binding site [chemical binding]; other site 164757010817 Walker B motif; other site 164757010818 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 164757010819 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 164757010820 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 164757010821 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 164757010822 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 164757010823 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 164757010824 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 164757010825 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 164757010826 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 164757010827 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 164757010828 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 164757010829 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 164757010830 Mg++ binding site [ion binding]; other site 164757010831 putative catalytic motif [active] 164757010832 substrate binding site [chemical binding]; other site 164757010833 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 164757010834 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 164757010835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757010836 S-adenosylmethionine binding site [chemical binding]; other site 164757010837 peptide chain release factor 1; Validated; Region: prfA; PRK00591 164757010838 This domain is found in peptide chain release factors; Region: PCRF; smart00937 164757010839 RF-1 domain; Region: RF-1; pfam00472 164757010840 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 164757010841 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757010842 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757010843 MarR family; Region: MarR_2; pfam12802 164757010844 acyl-CoA synthetase; Provisional; Region: PRK13388 164757010845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757010846 acyl-activating enzyme (AAE) consensus motif; other site 164757010847 AMP binding site [chemical binding]; other site 164757010848 active site 164757010849 CoA binding site [chemical binding]; other site 164757010850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757010851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757010852 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 164757010853 transcription termination factor Rho; Provisional; Region: PRK12608 164757010854 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 164757010855 RNA binding site [nucleotide binding]; other site 164757010856 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 164757010857 multimer interface [polypeptide binding]; other site 164757010858 Walker A motif; other site 164757010859 ATP binding site [chemical binding]; other site 164757010860 Walker B motif; other site 164757010861 homoserine kinase; Provisional; Region: PRK01212 164757010862 threonine synthase; Reviewed; Region: PRK06721 164757010863 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 164757010864 homodimer interface [polypeptide binding]; other site 164757010865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757010866 catalytic residue [active] 164757010867 homoserine dehydrogenase; Provisional; Region: PRK06349 164757010868 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 164757010869 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 164757010870 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 164757010871 diaminopimelate decarboxylase; Region: lysA; TIGR01048 164757010872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 164757010873 active site 164757010874 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 164757010875 substrate binding site [chemical binding]; other site 164757010876 catalytic residues [active] 164757010877 dimer interface [polypeptide binding]; other site 164757010878 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 164757010879 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 164757010880 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 164757010881 active site 164757010882 HIGH motif; other site 164757010883 KMSK motif region; other site 164757010884 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 164757010885 tRNA binding surface [nucleotide binding]; other site 164757010886 anticodon binding site; other site 164757010887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757010888 salt bridge; other site 164757010889 non-specific DNA binding site [nucleotide binding]; other site 164757010890 sequence-specific DNA binding site [nucleotide binding]; other site 164757010891 Domain of unknown function (DUF955); Region: DUF955; cl01076 164757010892 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 164757010893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 164757010894 Uncharacterized conserved protein [Function unknown]; Region: COG5323 164757010895 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757010896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757010897 S-adenosylmethionine binding site [chemical binding]; other site 164757010898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757010899 dimerization interface [polypeptide binding]; other site 164757010900 putative DNA binding site [nucleotide binding]; other site 164757010901 putative Zn2+ binding site [ion binding]; other site 164757010902 Cation efflux family; Region: Cation_efflux; cl00316 164757010903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757010904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757010905 S-adenosylmethionine binding site [chemical binding]; other site 164757010906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757010907 dimerization interface [polypeptide binding]; other site 164757010908 putative DNA binding site [nucleotide binding]; other site 164757010909 putative Zn2+ binding site [ion binding]; other site 164757010910 Cation efflux family; Region: Cation_efflux; cl00316 164757010911 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 164757010912 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 164757010913 catalytic residues [active] 164757010914 catalytic nucleophile [active] 164757010915 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 164757010916 AAA domain; Region: AAA_25; pfam13481 164757010917 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 164757010918 Walker A motif; other site 164757010919 ATP binding site [chemical binding]; other site 164757010920 Walker B motif; other site 164757010921 Helix-turn-helix domain; Region: HTH_17; cl17695 164757010922 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 164757010923 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757010924 active site 164757010925 DNA binding site [nucleotide binding] 164757010926 Int/Topo IB signature motif; other site 164757010927 MASE1; Region: MASE1; cl17823 164757010928 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757010929 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 164757010930 putative NAD(P) binding site [chemical binding]; other site 164757010931 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 164757010932 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 164757010933 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 164757010934 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 164757010935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757010936 putative ADP-binding pocket [chemical binding]; other site 164757010937 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 164757010938 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757010939 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 164757010940 Putative sensor; Region: Sensor; pfam13796 164757010941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 164757010942 Histidine kinase; Region: HisKA_3; pfam07730 164757010943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757010945 active site 164757010946 phosphorylation site [posttranslational modification] 164757010947 intermolecular recognition site; other site 164757010948 dimerization interface [polypeptide binding]; other site 164757010949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757010950 DNA binding residues [nucleotide binding] 164757010951 dimerization interface [polypeptide binding]; other site 164757010952 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 164757010953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757010954 metal binding site [ion binding]; metal-binding site 164757010955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757010956 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757010957 putative substrate translocation pore; other site 164757010958 Uncharacterized conserved protein [Function unknown]; Region: COG2966 164757010959 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 164757010960 Rrf2 family protein; Region: rrf2_super; TIGR00738 164757010961 Transcriptional regulator; Region: Rrf2; pfam02082 164757010962 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 164757010963 Isochorismatase family; Region: Isochorismatase; pfam00857 164757010964 catalytic triad [active] 164757010965 conserved cis-peptide bond; other site 164757010966 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 164757010967 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 164757010968 active site 164757010969 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 164757010970 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 164757010971 CysD dimerization site [polypeptide binding]; other site 164757010972 G1 box; other site 164757010973 putative GEF interaction site [polypeptide binding]; other site 164757010974 GTP/Mg2+ binding site [chemical binding]; other site 164757010975 Switch I region; other site 164757010976 G2 box; other site 164757010977 G3 box; other site 164757010978 Switch II region; other site 164757010979 G4 box; other site 164757010980 G5 box; other site 164757010981 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 164757010982 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 164757010983 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 164757010984 ligand-binding site [chemical binding]; other site 164757010985 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 164757010986 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 164757010987 Active Sites [active] 164757010988 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757010989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757010990 active site 164757010991 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 164757010992 active site clefts [active] 164757010993 zinc binding site [ion binding]; other site 164757010994 dimer interface [polypeptide binding]; other site 164757010995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 164757010996 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 164757010997 Ligand binding site; other site 164757010998 Ligand binding site; other site 164757010999 Ligand binding site; other site 164757011000 Putative Catalytic site; other site 164757011001 DXD motif; other site 164757011002 Predicted membrane protein [Function unknown]; Region: COG2246 164757011003 GtrA-like protein; Region: GtrA; pfam04138 164757011004 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 164757011005 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 164757011006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757011007 HAMP domain; Region: HAMP; pfam00672 164757011008 dimerization interface [polypeptide binding]; other site 164757011009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757011010 dimer interface [polypeptide binding]; other site 164757011011 phosphorylation site [posttranslational modification] 164757011012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757011013 ATP binding site [chemical binding]; other site 164757011014 Mg2+ binding site [ion binding]; other site 164757011015 G-X-G motif; other site 164757011016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757011017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757011018 active site 164757011019 phosphorylation site [posttranslational modification] 164757011020 intermolecular recognition site; other site 164757011021 dimerization interface [polypeptide binding]; other site 164757011022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757011023 DNA binding site [nucleotide binding] 164757011024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 164757011025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757011026 putative PBP binding loops; other site 164757011027 dimer interface [polypeptide binding]; other site 164757011028 ABC-ATPase subunit interface; other site 164757011029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 164757011030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757011031 dimer interface [polypeptide binding]; other site 164757011032 conserved gate region; other site 164757011033 putative PBP binding loops; other site 164757011034 ABC-ATPase subunit interface; other site 164757011035 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 164757011036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757011037 Walker A/P-loop; other site 164757011038 ATP binding site [chemical binding]; other site 164757011039 Q-loop/lid; other site 164757011040 ABC transporter signature motif; other site 164757011041 Walker B; other site 164757011042 D-loop; other site 164757011043 H-loop/switch region; other site 164757011044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 164757011045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 164757011046 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 164757011047 Walker A/P-loop; other site 164757011048 ATP binding site [chemical binding]; other site 164757011049 Q-loop/lid; other site 164757011050 ABC transporter signature motif; other site 164757011051 Walker B; other site 164757011052 D-loop; other site 164757011053 H-loop/switch region; other site 164757011054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 164757011055 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 164757011056 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 164757011057 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011058 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 164757011059 active site 164757011060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757011061 Walker A/P-loop; other site 164757011062 ATP binding site [chemical binding]; other site 164757011063 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 164757011064 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 164757011065 active site 164757011066 metal binding site [ion binding]; metal-binding site 164757011067 DNA binding site [nucleotide binding] 164757011068 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757011069 catalytic core [active] 164757011070 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 164757011071 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 164757011072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 164757011073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 164757011074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757011075 Walker A/P-loop; other site 164757011076 ATP binding site [chemical binding]; other site 164757011077 Q-loop/lid; other site 164757011078 ABC transporter signature motif; other site 164757011079 Walker B; other site 164757011080 D-loop; other site 164757011081 H-loop/switch region; other site 164757011082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 164757011083 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 164757011084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757011085 Walker A/P-loop; other site 164757011086 ATP binding site [chemical binding]; other site 164757011087 Q-loop/lid; other site 164757011088 ABC transporter signature motif; other site 164757011089 Walker B; other site 164757011090 D-loop; other site 164757011091 H-loop/switch region; other site 164757011092 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 164757011093 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757011094 molybdopterin cofactor binding site; other site 164757011095 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 164757011096 molybdopterin cofactor binding site; other site 164757011097 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 164757011098 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 164757011099 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757011100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011101 acyl-activating enzyme (AAE) consensus motif; other site 164757011102 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011103 AMP binding site [chemical binding]; other site 164757011104 active site 164757011105 acyl-activating enzyme (AAE) consensus motif; other site 164757011106 CoA binding site [chemical binding]; other site 164757011107 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 164757011108 metal-binding site [ion binding] 164757011109 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 164757011110 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 164757011111 metal-binding site [ion binding] 164757011112 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757011113 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757011114 cyclase homology domain; Region: CHD; cd07302 164757011115 nucleotidyl binding site; other site 164757011116 metal binding site [ion binding]; metal-binding site 164757011117 dimer interface [polypeptide binding]; other site 164757011118 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 164757011119 putative active site [active] 164757011120 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757011121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757011122 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 164757011123 putative dimer interface [polypeptide binding]; other site 164757011124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757011125 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 164757011126 HIT family signature motif; other site 164757011127 catalytic residue [active] 164757011128 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757011129 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 164757011130 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757011131 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 164757011132 Fe-S cluster binding site [ion binding]; other site 164757011133 DNA binding site [nucleotide binding] 164757011134 active site 164757011135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757011136 H+ Antiporter protein; Region: 2A0121; TIGR00900 164757011137 putative substrate translocation pore; other site 164757011138 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757011139 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 164757011140 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 164757011141 FAD binding domain; Region: FAD_binding_4; pfam01565 164757011142 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 164757011143 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011144 Cytochrome P450; Region: p450; cl12078 164757011145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011147 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 164757011148 Sulfatase; Region: Sulfatase; pfam00884 164757011149 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 164757011150 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 164757011151 FAD binding pocket [chemical binding]; other site 164757011152 FAD binding motif [chemical binding]; other site 164757011153 phosphate binding motif [ion binding]; other site 164757011154 NAD binding pocket [chemical binding]; other site 164757011155 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757011156 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 164757011157 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 164757011158 ATP binding site [chemical binding]; other site 164757011159 Mg++ binding site [ion binding]; other site 164757011160 motif III; other site 164757011161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757011162 nucleotide binding region [chemical binding]; other site 164757011163 ATP-binding site [chemical binding]; other site 164757011164 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 164757011165 putative RNA binding site [nucleotide binding]; other site 164757011166 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 164757011167 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 164757011168 RNase_H superfamily; Region: RNase_H_2; pfam13482 164757011169 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 164757011170 Part of AAA domain; Region: AAA_19; pfam13245 164757011171 AAA domain; Region: AAA_12; pfam13087 164757011172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757011173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757011174 putative substrate translocation pore; other site 164757011175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757011176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757011177 putative substrate translocation pore; other site 164757011178 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 164757011179 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 164757011180 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 164757011181 TPP-binding site [chemical binding]; other site 164757011182 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 164757011183 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757011184 short chain dehydrogenase; Provisional; Region: PRK07832 164757011185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011186 NAD(P) binding site [chemical binding]; other site 164757011187 active site 164757011188 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 164757011189 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 164757011190 Malic enzyme, N-terminal domain; Region: malic; pfam00390 164757011191 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 164757011192 putative NAD(P) binding site [chemical binding]; other site 164757011193 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 164757011194 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 164757011195 oligomer interface [polypeptide binding]; other site 164757011196 metal binding site [ion binding]; metal-binding site 164757011197 metal binding site [ion binding]; metal-binding site 164757011198 putative Cl binding site [ion binding]; other site 164757011199 basic sphincter; other site 164757011200 hydrophobic gate; other site 164757011201 periplasmic entrance; other site 164757011202 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 164757011203 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 164757011204 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 164757011205 Walker A/P-loop; other site 164757011206 ATP binding site [chemical binding]; other site 164757011207 Q-loop/lid; other site 164757011208 ABC transporter signature motif; other site 164757011209 Walker B; other site 164757011210 D-loop; other site 164757011211 H-loop/switch region; other site 164757011212 TOBE domain; Region: TOBE_2; pfam08402 164757011213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 164757011214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757011215 dimer interface [polypeptide binding]; other site 164757011216 conserved gate region; other site 164757011217 putative PBP binding loops; other site 164757011218 ABC-ATPase subunit interface; other site 164757011219 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 164757011220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757011221 dimer interface [polypeptide binding]; other site 164757011222 conserved gate region; other site 164757011223 putative PBP binding loops; other site 164757011224 ABC-ATPase subunit interface; other site 164757011225 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 164757011226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 164757011227 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 164757011228 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 164757011229 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 164757011230 MgtE intracellular N domain; Region: MgtE_N; smart00924 164757011231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 164757011232 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 164757011233 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 164757011234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 164757011235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 164757011236 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 164757011237 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 164757011238 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 164757011239 sec-independent translocase; Provisional; Region: PRK03100 164757011240 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 164757011241 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757011242 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 164757011243 protein binding site [polypeptide binding]; other site 164757011244 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 164757011245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757011246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757011247 DNA binding residues [nucleotide binding] 164757011248 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 164757011249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757011250 S-adenosylmethionine binding site [chemical binding]; other site 164757011251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 164757011254 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 164757011255 Walker A/P-loop; other site 164757011256 ATP binding site [chemical binding]; other site 164757011257 Q-loop/lid; other site 164757011258 ABC transporter signature motif; other site 164757011259 Walker B; other site 164757011260 D-loop; other site 164757011261 H-loop/switch region; other site 164757011262 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 164757011263 short chain dehydrogenase; Provisional; Region: PRK08278 164757011264 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 164757011265 NAD(P) binding site [chemical binding]; other site 164757011266 homodimer interface [polypeptide binding]; other site 164757011267 active site 164757011268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011269 short chain dehydrogenase; Provisional; Region: PRK06197 164757011270 NAD(P) binding site [chemical binding]; other site 164757011271 active site 164757011272 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011273 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011274 active site 164757011275 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757011276 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757011277 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011278 Ecdysteroid kinase; Region: EcKinase; cl17738 164757011279 Phosphotransferase enzyme family; Region: APH; pfam01636 164757011280 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757011281 classical (c) SDRs; Region: SDR_c; cd05233 164757011282 NAD(P) binding site [chemical binding]; other site 164757011283 active site 164757011284 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757011285 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011286 lipid-transfer protein; Provisional; Region: PRK07855 164757011287 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011288 active site 164757011289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011290 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757011291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011292 active site 164757011293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011295 active site 164757011296 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 164757011297 putative FMN binding site [chemical binding]; other site 164757011298 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 164757011299 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757011300 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757011301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011302 Cytochrome P450; Region: p450; cl12078 164757011303 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 164757011304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757011306 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011307 Cytochrome P450; Region: p450; cl12078 164757011308 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757011309 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 164757011310 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 164757011311 active site 164757011312 metal binding site [ion binding]; metal-binding site 164757011313 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011314 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011319 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757011320 active site 2 [active] 164757011321 active site 1 [active] 164757011322 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 164757011323 active site 2 [active] 164757011324 active site 1 [active] 164757011325 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 164757011326 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757011327 NAD binding site [chemical binding]; other site 164757011328 catalytic residues [active] 164757011329 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757011330 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757011331 NAD binding site [chemical binding]; other site 164757011332 catalytic Zn binding site [ion binding]; other site 164757011333 substrate binding site [chemical binding]; other site 164757011334 structural Zn binding site [ion binding]; other site 164757011335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 164757011336 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 164757011337 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011338 Cytochrome P450; Region: p450; cl12078 164757011339 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757011340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011341 substrate binding site [chemical binding]; other site 164757011342 oxyanion hole (OAH) forming residues; other site 164757011343 trimer interface [polypeptide binding]; other site 164757011344 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757011345 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757011346 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011347 short chain dehydrogenase; Provisional; Region: PRK07791 164757011348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011349 NAD(P) binding site [chemical binding]; other site 164757011350 active site 164757011351 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 164757011352 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757011353 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757011354 putative active site [active] 164757011355 putative substrate binding site [chemical binding]; other site 164757011356 Phosphotransferase enzyme family; Region: APH; pfam01636 164757011357 ATP binding site [chemical binding]; other site 164757011358 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757011359 classical (c) SDRs; Region: SDR_c; cd05233 164757011360 NAD(P) binding site [chemical binding]; other site 164757011361 active site 164757011362 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 164757011363 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757011364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757011365 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011366 Cytochrome P450; Region: p450; cl12078 164757011367 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 164757011368 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011369 lipid-transfer protein; Provisional; Region: PRK07855 164757011370 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011371 active site 164757011372 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757011373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011375 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011376 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011377 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011378 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011379 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 164757011380 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757011381 classical (c) SDRs; Region: SDR_c; cd05233 164757011382 NAD(P) binding site [chemical binding]; other site 164757011383 active site 164757011384 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757011385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011386 acyl-activating enzyme (AAE) consensus motif; other site 164757011387 AMP binding site [chemical binding]; other site 164757011388 active site 164757011389 CoA binding site [chemical binding]; other site 164757011390 thiolase; Provisional; Region: PRK06158 164757011391 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011392 active site 164757011393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011394 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757011395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011396 active site 164757011397 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 164757011398 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011399 active site 164757011400 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 164757011401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 164757011402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757011403 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011404 thiolase; Provisional; Region: PRK06158 164757011405 active site 164757011406 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011407 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 164757011408 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757011409 iron-sulfur cluster [ion binding]; other site 164757011410 [2Fe-2S] cluster binding site [ion binding]; other site 164757011411 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 164757011412 putative alpha subunit interface [polypeptide binding]; other site 164757011413 putative active site [active] 164757011414 putative substrate binding site [chemical binding]; other site 164757011415 Fe binding site [ion binding]; other site 164757011416 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757011417 inter-subunit interface; other site 164757011418 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757011419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011420 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757011421 acyl-activating enzyme (AAE) consensus motif; other site 164757011422 acyl-activating enzyme (AAE) consensus motif; other site 164757011423 putative AMP binding site [chemical binding]; other site 164757011424 putative active site [active] 164757011425 putative CoA binding site [chemical binding]; other site 164757011426 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757011427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011428 substrate binding site [chemical binding]; other site 164757011429 oxyanion hole (OAH) forming residues; other site 164757011430 trimer interface [polypeptide binding]; other site 164757011431 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757011432 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 164757011433 NAD(P) binding site [chemical binding]; other site 164757011434 catalytic residues [active] 164757011435 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 164757011436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011438 active site 164757011439 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757011440 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757011441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757011442 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757011443 active site 2 [active] 164757011444 active site 1 [active] 164757011445 short chain dehydrogenase; Provisional; Region: PRK06125 164757011446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011447 NAD(P) binding site [chemical binding]; other site 164757011448 active site 164757011449 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011450 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011453 Ferredoxin [Energy production and conversion]; Region: COG1146 164757011454 4Fe-4S binding domain; Region: Fer4; pfam00037 164757011455 ferredoxin-NADP+ reductase; Region: PLN02852 164757011456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757011457 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757011458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011459 substrate binding site [chemical binding]; other site 164757011460 oxyanion hole (OAH) forming residues; other site 164757011461 trimer interface [polypeptide binding]; other site 164757011462 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757011463 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 164757011464 acyl-activating enzyme (AAE) consensus motif; other site 164757011465 putative AMP binding site [chemical binding]; other site 164757011466 putative active site [active] 164757011467 putative CoA binding site [chemical binding]; other site 164757011468 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 164757011469 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757011470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011471 substrate binding site [chemical binding]; other site 164757011472 oxyanion hole (OAH) forming residues; other site 164757011473 trimer interface [polypeptide binding]; other site 164757011474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011476 active site 164757011477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757011478 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757011479 active site 2 [active] 164757011480 active site 1 [active] 164757011481 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757011482 classical (c) SDRs; Region: SDR_c; cd05233 164757011483 NAD(P) binding site [chemical binding]; other site 164757011484 active site 164757011485 enoyl-CoA hydratase; Provisional; Region: PRK08252 164757011486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011487 substrate binding site [chemical binding]; other site 164757011488 oxyanion hole (OAH) forming residues; other site 164757011489 trimer interface [polypeptide binding]; other site 164757011490 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757011491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011493 AMP binding site [chemical binding]; other site 164757011494 active site 164757011495 acyl-activating enzyme (AAE) consensus motif; other site 164757011496 acyl-activating enzyme (AAE) consensus motif; other site 164757011497 CoA binding site [chemical binding]; other site 164757011498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011499 active site 164757011500 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011501 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011502 active site 164757011503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011504 active site 164757011505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011507 active site 164757011508 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757011509 pyruvate phosphate dikinase; Provisional; Region: PRK05878 164757011510 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 164757011511 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 164757011512 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 164757011513 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757011514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011518 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757011519 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 164757011520 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757011521 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011522 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757011523 acyl-activating enzyme (AAE) consensus motif; other site 164757011524 acyl-activating enzyme (AAE) consensus motif; other site 164757011525 putative AMP binding site [chemical binding]; other site 164757011526 putative active site [active] 164757011527 putative CoA binding site [chemical binding]; other site 164757011528 lipid-transfer protein; Provisional; Region: PRK07855 164757011529 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011530 active site 164757011531 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 164757011532 putative active site [active] 164757011533 putative catalytic site [active] 164757011534 putative acyltransferase; Provisional; Region: PRK05790 164757011535 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757011536 dimer interface [polypeptide binding]; other site 164757011537 active site 164757011538 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757011539 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011540 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 164757011541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011543 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 164757011544 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 164757011545 FAD binding pocket [chemical binding]; other site 164757011546 FAD binding motif [chemical binding]; other site 164757011547 phosphate binding motif [ion binding]; other site 164757011548 beta-alpha-beta structure motif; other site 164757011549 NAD(p) ribose binding residues [chemical binding]; other site 164757011550 NAD binding pocket [chemical binding]; other site 164757011551 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 164757011552 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757011553 catalytic loop [active] 164757011554 iron binding site [ion binding]; other site 164757011555 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757011556 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757011557 iron-sulfur cluster [ion binding]; other site 164757011558 [2Fe-2S] cluster binding site [ion binding]; other site 164757011559 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757011560 hydrophobic ligand binding site; other site 164757011561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011562 Isochorismatase family; Region: Isochorismatase; pfam00857 164757011563 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 164757011564 catalytic triad [active] 164757011565 conserved cis-peptide bond; other site 164757011566 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757011567 DinB superfamily; Region: DinB_2; pfam12867 164757011568 metal-dependent hydrolase; Provisional; Region: PRK13291 164757011569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011571 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757011572 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757011573 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757011574 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757011575 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757011576 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757011577 putative acyl-acceptor binding pocket; other site 164757011578 acyl-CoA synthetase; Provisional; Region: PRK13382 164757011579 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757011580 acyl-activating enzyme (AAE) consensus motif; other site 164757011581 putative AMP binding site [chemical binding]; other site 164757011582 putative active site [active] 164757011583 putative CoA binding site [chemical binding]; other site 164757011584 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757011585 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011586 acyl-activating enzyme (AAE) consensus motif; other site 164757011587 AMP binding site [chemical binding]; other site 164757011588 active site 164757011589 CoA binding site [chemical binding]; other site 164757011590 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 164757011591 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011592 active site 164757011593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011594 Cytochrome P450; Region: p450; cl12078 164757011595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757011596 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757011597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011598 acyl-activating enzyme (AAE) consensus motif; other site 164757011599 AMP binding site [chemical binding]; other site 164757011600 active site 164757011601 CoA binding site [chemical binding]; other site 164757011602 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757011603 active site 164757011604 Amidohydrolase; Region: Amidohydro_2; pfam04909 164757011605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011606 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011607 active site 164757011608 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 164757011609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011610 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 164757011611 NAD(P) binding site [chemical binding]; other site 164757011612 active site 164757011613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757011614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757011615 putative substrate translocation pore; other site 164757011616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 164757011619 active site 164757011620 metal binding site [ion binding]; metal-binding site 164757011621 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011622 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011623 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757011624 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757011625 NAD binding site [chemical binding]; other site 164757011626 catalytic residues [active] 164757011627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011629 active site 164757011630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011634 active site 164757011635 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757011636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757011637 DNA-binding site [nucleotide binding]; DNA binding site 164757011638 FCD domain; Region: FCD; pfam07729 164757011639 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 164757011640 active site 2 [active] 164757011641 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757011642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011643 substrate binding site [chemical binding]; other site 164757011644 oxyanion hole (OAH) forming residues; other site 164757011645 trimer interface [polypeptide binding]; other site 164757011646 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 164757011647 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757011648 active site 164757011649 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757011650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011651 NAD(P) binding site [chemical binding]; other site 164757011652 active site 164757011653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011654 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011655 active site 164757011656 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011657 active site 164757011658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757011660 NAD(P) binding site [chemical binding]; other site 164757011661 active site 164757011662 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757011663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757011664 substrate binding site [chemical binding]; other site 164757011665 oxyanion hole (OAH) forming residues; other site 164757011666 trimer interface [polypeptide binding]; other site 164757011667 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 164757011668 classical (c) SDRs; Region: SDR_c; cd05233 164757011669 NAD(P) binding site [chemical binding]; other site 164757011670 active site 164757011671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011672 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 164757011673 NAD(P) binding site [chemical binding]; other site 164757011674 active site 164757011675 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011676 Cytochrome P450; Region: p450; cl12078 164757011677 acyl-CoA synthetase; Provisional; Region: PRK13391 164757011678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011679 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757011680 acyl-activating enzyme (AAE) consensus motif; other site 164757011681 putative AMP binding site [chemical binding]; other site 164757011682 putative active site [active] 164757011683 putative CoA binding site [chemical binding]; other site 164757011684 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 164757011685 Isochorismatase family; Region: Isochorismatase; pfam00857 164757011686 catalytic triad [active] 164757011687 conserved cis-peptide bond; other site 164757011688 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011689 mce related protein; Region: MCE; pfam02470 164757011690 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011691 mce related protein; Region: MCE; pfam02470 164757011692 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757011693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011694 mce related protein; Region: MCE; pfam02470 164757011695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011696 mce related protein; Region: MCE; pfam02470 164757011697 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011698 mce related protein; Region: MCE; pfam02470 164757011699 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011700 mce related protein; Region: MCE; pfam02470 164757011701 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757011702 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757011703 Permease; Region: Permease; pfam02405 164757011704 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757011705 Permease; Region: Permease; pfam02405 164757011706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011708 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 164757011709 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757011710 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757011711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757011712 DNA-binding site [nucleotide binding]; DNA binding site 164757011713 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 164757011714 Cytochrome P450; Region: p450; cl12078 164757011715 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757011716 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011719 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757011720 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757011721 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 164757011722 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 164757011723 putative NADP binding site [chemical binding]; other site 164757011724 putative substrate binding site [chemical binding]; other site 164757011725 active site 164757011726 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757011727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011729 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011730 mce related protein; Region: MCE; pfam02470 164757011731 mce related protein; Region: MCE; pfam02470 164757011732 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011733 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011734 mce related protein; Region: MCE; pfam02470 164757011735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011736 mce related protein; Region: MCE; pfam02470 164757011737 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011738 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757011739 mce related protein; Region: MCE; pfam02470 164757011740 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757011741 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757011742 Permease; Region: Permease; pfam02405 164757011743 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757011744 Permease; Region: Permease; pfam02405 164757011745 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011747 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 164757011748 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 164757011749 YceI-like domain; Region: YceI; pfam04264 164757011750 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757011751 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757011752 iron-sulfur cluster [ion binding]; other site 164757011753 [2Fe-2S] cluster binding site [ion binding]; other site 164757011754 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757011755 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757011756 beta subunit interface [polypeptide binding]; other site 164757011757 alpha subunit interface [polypeptide binding]; other site 164757011758 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757011759 classical (c) SDRs; Region: SDR_c; cd05233 164757011760 NAD(P) binding site [chemical binding]; other site 164757011761 active site 164757011762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757011763 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757011764 active site 164757011765 metal binding site [ion binding]; metal-binding site 164757011766 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757011767 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 164757011768 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011769 active site 164757011770 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 164757011771 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 164757011772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757011773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757011774 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 164757011775 Cupin domain; Region: Cupin_2; pfam07883 164757011776 Cupin domain; Region: Cupin_2; cl17218 164757011777 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 164757011778 Class I aldolases; Region: Aldolase_Class_I; cl17187 164757011779 catalytic residue [active] 164757011780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757011781 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 164757011782 NAD binding site [chemical binding]; other site 164757011783 catalytic residues [active] 164757011784 Tautomerase enzyme; Region: Tautomerase; pfam01361 164757011785 active site 1 [active] 164757011786 dimer interface [polypeptide binding]; other site 164757011787 hexamer interface [polypeptide binding]; other site 164757011788 active site 2 [active] 164757011789 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 164757011790 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 164757011791 N-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC); Region: PpCmtC_N; cd08361 164757011792 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 164757011793 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 164757011794 active site 164757011795 metal binding site [ion binding]; metal-binding site 164757011796 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757011797 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 164757011798 NAD(P) binding site [chemical binding]; other site 164757011799 catalytic residues [active] 164757011800 catalytic residues [active] 164757011801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757011802 MarR family; Region: MarR; pfam01047 164757011803 MarR family; Region: MarR_2; cl17246 164757011804 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757011805 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 164757011806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757011807 Bacterial transcriptional regulator; Region: IclR; pfam01614 164757011808 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 164757011809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757011810 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 164757011811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757011812 NAD(P) binding site [chemical binding]; other site 164757011813 active site 164757011814 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 164757011815 inter-subunit interface; other site 164757011816 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757011817 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757011818 iron-sulfur cluster [ion binding]; other site 164757011819 [2Fe-2S] cluster binding site [ion binding]; other site 164757011820 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 164757011821 beta subunit interface [polypeptide binding]; other site 164757011822 alpha subunit interface [polypeptide binding]; other site 164757011823 active site 164757011824 substrate binding site [chemical binding]; other site 164757011825 Fe binding site [ion binding]; other site 164757011826 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 164757011827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757011828 putative DNA binding site [nucleotide binding]; other site 164757011829 putative Zn2+ binding site [ion binding]; other site 164757011830 AsnC family; Region: AsnC_trans_reg; pfam01037 164757011831 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 164757011832 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 164757011833 dimer interface [polypeptide binding]; other site 164757011834 PYR/PP interface [polypeptide binding]; other site 164757011835 TPP binding site [chemical binding]; other site 164757011836 substrate binding site [chemical binding]; other site 164757011837 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 164757011838 TPP-binding site [chemical binding]; other site 164757011839 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 164757011840 acetaldehyde dehydrogenase; Validated; Region: PRK08300 164757011841 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 164757011842 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 164757011843 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 164757011844 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 164757011845 active site 164757011846 catalytic residues [active] 164757011847 metal binding site [ion binding]; metal-binding site 164757011848 DmpG-like communication domain; Region: DmpG_comm; pfam07836 164757011849 Predicted membrane protein [Function unknown]; Region: COG2259 164757011850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757011851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757011852 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 164757011853 putative dimerization interface [polypeptide binding]; other site 164757011854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011856 active site 164757011857 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757011858 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757011859 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 164757011860 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 164757011861 ligand binding site; other site 164757011862 oligomer interface; other site 164757011863 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 164757011864 dimer interface [polypeptide binding]; other site 164757011865 N-terminal domain interface [polypeptide binding]; other site 164757011866 sulfate 1 binding site; other site 164757011867 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 164757011868 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757011869 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 164757011870 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 164757011871 DivIVA domain; Region: DivI1A_domain; TIGR03544 164757011872 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 164757011873 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 164757011874 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 164757011875 dihydropteroate synthase; Region: DHPS; TIGR01496 164757011876 substrate binding pocket [chemical binding]; other site 164757011877 dimer interface [polypeptide binding]; other site 164757011878 inhibitor binding site; inhibition site 164757011879 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 164757011880 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 164757011881 acyl-activating enzyme (AAE) consensus motif; other site 164757011882 putative AMP binding site [chemical binding]; other site 164757011883 putative active site [active] 164757011884 putative CoA binding site [chemical binding]; other site 164757011885 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 164757011886 AAA domain; Region: AAA_22; pfam13401 164757011887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757011888 Walker A motif; other site 164757011889 ATP binding site [chemical binding]; other site 164757011890 Walker B motif; other site 164757011891 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 164757011892 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 164757011893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757011894 Walker A/P-loop; other site 164757011895 ATP binding site [chemical binding]; other site 164757011896 Q-loop/lid; other site 164757011897 ABC transporter signature motif; other site 164757011898 Walker B; other site 164757011899 D-loop; other site 164757011900 H-loop/switch region; other site 164757011901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757011902 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 164757011903 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 164757011904 metal binding site [ion binding]; metal-binding site 164757011905 putative dimer interface [polypeptide binding]; other site 164757011906 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 164757011907 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 164757011908 putative trimer interface [polypeptide binding]; other site 164757011909 putative CoA binding site [chemical binding]; other site 164757011910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757011911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757011912 active site residue [active] 164757011913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 164757011914 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757011915 putative homodimer interface [polypeptide binding]; other site 164757011916 putative homotetramer interface [polypeptide binding]; other site 164757011917 putative allosteric switch controlling residues; other site 164757011918 putative metal binding site [ion binding]; other site 164757011919 putative homodimer-homodimer interface [polypeptide binding]; other site 164757011920 Domain of unknown function DUF302; Region: DUF302; cl01364 164757011921 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 164757011922 active site 164757011923 acyl-CoA synthetase; Validated; Region: PRK07787 164757011924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757011925 acyl-activating enzyme (AAE) consensus motif; other site 164757011926 AMP binding site [chemical binding]; other site 164757011927 active site 164757011928 CoA binding site [chemical binding]; other site 164757011929 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 164757011930 dimer interface [polypeptide binding]; other site 164757011931 ADP-ribose binding site [chemical binding]; other site 164757011932 active site 164757011933 nudix motif; other site 164757011934 metal binding site [ion binding]; metal-binding site 164757011935 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757011936 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 164757011937 SnoaL-like domain; Region: SnoaL_3; pfam13474 164757011938 Proline dehydrogenase; Region: Pro_dh; cl03282 164757011939 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 164757011940 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 164757011941 Glutamate binding site [chemical binding]; other site 164757011942 NAD binding site [chemical binding]; other site 164757011943 catalytic residues [active] 164757011944 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 164757011945 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757011946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757011947 active site 164757011948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757011949 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 164757011950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757011951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757011952 homodimer interface [polypeptide binding]; other site 164757011953 catalytic residue [active] 164757011954 Ferredoxin [Energy production and conversion]; Region: COG1146 164757011955 4Fe-4S binding domain; Region: Fer4; pfam00037 164757011956 Uncharacterized conserved protein [Function unknown]; Region: COG2353 164757011957 FO synthase; Reviewed; Region: fbiC; PRK09234 164757011958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757011959 FeS/SAM binding site; other site 164757011960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757011961 FeS/SAM binding site; other site 164757011962 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 164757011963 putative minor structural protein; Region: PHA01351 164757011964 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 164757011965 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 164757011966 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 164757011967 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 164757011968 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 164757011969 G1 box; other site 164757011970 putative GEF interaction site [polypeptide binding]; other site 164757011971 GTP/Mg2+ binding site [chemical binding]; other site 164757011972 Switch I region; other site 164757011973 G2 box; other site 164757011974 G3 box; other site 164757011975 Switch II region; other site 164757011976 G4 box; other site 164757011977 G5 box; other site 164757011978 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 164757011979 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 164757011980 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 164757011981 active site 164757011982 8-oxo-dGMP binding site [chemical binding]; other site 164757011983 nudix motif; other site 164757011984 metal binding site [ion binding]; metal-binding site 164757011985 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 164757011986 aromatic arch; other site 164757011987 DCoH dimer interaction site [polypeptide binding]; other site 164757011988 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 164757011989 DCoH tetramer interaction site [polypeptide binding]; other site 164757011990 substrate binding site [chemical binding]; other site 164757011991 mannosyltransferase; Provisional; Region: pimE; PRK13375 164757011992 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 164757011993 uncharacterized HhH-GPD family protein; Region: TIGR03252 164757011994 minor groove reading motif; other site 164757011995 helix-hairpin-helix signature motif; other site 164757011996 Histidine kinase; Region: His_kinase; pfam06580 164757011997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757011998 ATP binding site [chemical binding]; other site 164757011999 Mg2+ binding site [ion binding]; other site 164757012000 G-X-G motif; other site 164757012001 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 164757012002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012003 active site 164757012004 phosphorylation site [posttranslational modification] 164757012005 intermolecular recognition site; other site 164757012006 dimerization interface [polypeptide binding]; other site 164757012007 LytTr DNA-binding domain; Region: LytTR; smart00850 164757012008 Protein of unknown function, DUF485; Region: DUF485; pfam04341 164757012009 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 164757012010 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 164757012011 Protein of unknown function, DUF485; Region: DUF485; pfam04341 164757012012 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 164757012013 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 164757012014 Na binding site [ion binding]; other site 164757012015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012016 putative substrate translocation pore; other site 164757012017 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757012018 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 164757012019 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757012020 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 164757012021 Predicted transcriptional regulators [Transcription]; Region: COG1725 164757012022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757012023 DNA-binding site [nucleotide binding]; DNA binding site 164757012024 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 164757012025 NAD-dependent deacetylase; Provisional; Region: PRK00481 164757012026 NAD+ binding site [chemical binding]; other site 164757012027 substrate binding site [chemical binding]; other site 164757012028 Zn binding site [ion binding]; other site 164757012029 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757012030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757012031 S-adenosylmethionine binding site [chemical binding]; other site 164757012032 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 164757012033 DoxX; Region: DoxX; pfam07681 164757012034 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 164757012035 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757012036 FMN binding site [chemical binding]; other site 164757012037 substrate binding site [chemical binding]; other site 164757012038 putative catalytic residue [active] 164757012039 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 164757012040 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 164757012041 NAD binding site [chemical binding]; other site 164757012042 homodimer interface [polypeptide binding]; other site 164757012043 homotetramer interface [polypeptide binding]; other site 164757012044 active site 164757012045 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757012046 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757012047 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757012048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757012049 substrate binding site [chemical binding]; other site 164757012050 oxyanion hole (OAH) forming residues; other site 164757012051 trimer interface [polypeptide binding]; other site 164757012052 HicB family; Region: HicB; pfam05534 164757012053 H+ Antiporter protein; Region: 2A0121; TIGR00900 164757012054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012055 CAAX protease self-immunity; Region: Abi; pfam02517 164757012056 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 164757012057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757012058 NAD(P) binding site [chemical binding]; other site 164757012059 active site 164757012060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757012063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757012064 active site 164757012065 catalytic tetrad [active] 164757012066 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 164757012067 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 164757012068 trimer interface [polypeptide binding]; other site 164757012069 putative metal binding site [ion binding]; other site 164757012070 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 164757012071 Fasciclin domain; Region: Fasciclin; pfam02469 164757012072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757012073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757012074 active site 164757012075 enoyl-CoA hydratase; Provisional; Region: PRK08252 164757012076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757012077 substrate binding site [chemical binding]; other site 164757012078 oxyanion hole (OAH) forming residues; other site 164757012079 trimer interface [polypeptide binding]; other site 164757012080 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 164757012081 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757012082 dimer interface [polypeptide binding]; other site 164757012083 active site 164757012084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757012085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757012086 FCD domain; Region: FCD; pfam07729 164757012087 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 164757012088 Predicted membrane protein [Function unknown]; Region: COG2259 164757012089 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757012090 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757012091 classical (c) SDRs; Region: SDR_c; cd05233 164757012092 NAD(P) binding site [chemical binding]; other site 164757012093 active site 164757012094 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757012095 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 164757012096 dimer interface [polypeptide binding]; other site 164757012097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757012098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757012099 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 164757012100 hypothetical protein; Provisional; Region: PRK06149 164757012101 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 164757012102 active site 164757012103 ATP binding site [chemical binding]; other site 164757012104 substrate binding site [chemical binding]; other site 164757012105 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757012106 inhibitor-cofactor binding pocket; inhibition site 164757012107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012108 catalytic residue [active] 164757012109 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757012110 cyclase homology domain; Region: CHD; cd07302 164757012111 nucleotidyl binding site; other site 164757012112 metal binding site [ion binding]; metal-binding site 164757012113 dimer interface [polypeptide binding]; other site 164757012114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757012115 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757012116 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757012117 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 164757012118 putative hydrophobic ligand binding site [chemical binding]; other site 164757012119 Domain of unknown function (DU1801); Region: DUF1801; cl17490 164757012120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757012121 dimerization interface [polypeptide binding]; other site 164757012122 putative DNA binding site [nucleotide binding]; other site 164757012123 putative Zn2+ binding site [ion binding]; other site 164757012124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757012125 active site residue [active] 164757012126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757012128 putative substrate translocation pore; other site 164757012129 Methyltransferase domain; Region: Methyltransf_23; pfam13489 164757012130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757012131 S-adenosylmethionine binding site [chemical binding]; other site 164757012132 GTP-binding protein YchF; Reviewed; Region: PRK09601 164757012133 YchF GTPase; Region: YchF; cd01900 164757012134 G1 box; other site 164757012135 GTP/Mg2+ binding site [chemical binding]; other site 164757012136 Switch I region; other site 164757012137 G2 box; other site 164757012138 Switch II region; other site 164757012139 G3 box; other site 164757012140 G4 box; other site 164757012141 G5 box; other site 164757012142 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 164757012143 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 164757012144 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 164757012145 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 164757012146 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 164757012147 generic binding surface II; other site 164757012148 generic binding surface I; other site 164757012149 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 164757012150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757012151 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 164757012152 NAD(P) binding site [chemical binding]; other site 164757012153 active site 164757012154 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 164757012155 MgtC family; Region: MgtC; pfam02308 164757012156 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 164757012157 Sulfatase; Region: Sulfatase; pfam00884 164757012158 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 164757012159 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 164757012160 Uncharacterized conserved protein [Function unknown]; Region: COG1262 164757012161 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 164757012162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757012163 classical (c) SDRs; Region: SDR_c; cd05233 164757012164 NAD(P) binding site [chemical binding]; other site 164757012165 active site 164757012166 classical (c) SDRs; Region: SDR_c; cd05233 164757012167 short chain dehydrogenase; Provisional; Region: PRK05650 164757012168 NAD(P) binding site [chemical binding]; other site 164757012169 active site 164757012170 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 164757012171 Domain of unknown function DUF20; Region: UPF0118; pfam01594 164757012172 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 164757012173 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 164757012174 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 164757012175 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 164757012176 putative active site [active] 164757012177 fumarate hydratase; Reviewed; Region: fumC; PRK00485 164757012178 Class II fumarases; Region: Fumarase_classII; cd01362 164757012179 active site 164757012180 tetramer interface [polypeptide binding]; other site 164757012181 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757012182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757012183 NAD(P) binding site [chemical binding]; other site 164757012184 active site 164757012185 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757012186 dimer interface [polypeptide binding]; other site 164757012187 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757012188 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 164757012189 GAF domain; Region: GAF_3; pfam13492 164757012190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757012191 Histidine kinase; Region: HisKA_3; pfam07730 164757012192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012193 ATP binding site [chemical binding]; other site 164757012194 Mg2+ binding site [ion binding]; other site 164757012195 G-X-G motif; other site 164757012196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757012197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012198 active site 164757012199 phosphorylation site [posttranslational modification] 164757012200 intermolecular recognition site; other site 164757012201 dimerization interface [polypeptide binding]; other site 164757012202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757012203 DNA binding residues [nucleotide binding] 164757012204 dimerization interface [polypeptide binding]; other site 164757012205 Universal stress protein family; Region: Usp; pfam00582 164757012206 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757012207 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 164757012208 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 164757012209 putative active site [active] 164757012210 PhoH-like protein; Region: PhoH; pfam02562 164757012211 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 164757012212 dinuclear metal binding motif [ion binding]; other site 164757012213 serine hydroxymethyltransferase; Provisional; Region: PRK13580 164757012214 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 164757012215 dimer interface [polypeptide binding]; other site 164757012216 active site 164757012217 glycine-pyridoxal phosphate binding site [chemical binding]; other site 164757012218 folate binding site [chemical binding]; other site 164757012219 pantothenate kinase; Provisional; Region: PRK05439 164757012220 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 164757012221 ATP-binding site [chemical binding]; other site 164757012222 CoA-binding site [chemical binding]; other site 164757012223 Mg2+-binding site [ion binding]; other site 164757012224 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 164757012225 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 164757012226 catalytic residue [active] 164757012227 putative FPP diphosphate binding site; other site 164757012228 putative FPP binding hydrophobic cleft; other site 164757012229 dimer interface [polypeptide binding]; other site 164757012230 putative IPP diphosphate binding site; other site 164757012231 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 164757012232 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 164757012233 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757012234 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 164757012235 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 164757012236 catalytic residues [active] 164757012237 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 164757012238 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 164757012239 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 164757012240 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 164757012241 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 164757012242 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 164757012243 cystathionine gamma-synthase; Provisional; Region: PRK07811 164757012244 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 164757012245 homodimer interface [polypeptide binding]; other site 164757012246 substrate-cofactor binding pocket; other site 164757012247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012248 catalytic residue [active] 164757012249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757012250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757012251 active site 164757012252 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 164757012253 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 164757012254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 164757012255 dimer interface [polypeptide binding]; other site 164757012256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012257 catalytic residue [active] 164757012258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 164757012259 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 164757012260 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 164757012261 active site 164757012262 catalytic triad [active] 164757012263 oxyanion hole [active] 164757012264 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 164757012265 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757012266 dimer interface [polypeptide binding]; other site 164757012267 active site 164757012268 Bax inhibitor 1 like; Region: BaxI_1; cl17691 164757012269 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 164757012270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757012271 substrate binding site [chemical binding]; other site 164757012272 oxyanion hole (OAH) forming residues; other site 164757012273 trimer interface [polypeptide binding]; other site 164757012274 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 164757012275 enoyl-CoA hydratase; Provisional; Region: PRK05862 164757012276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757012277 substrate binding site [chemical binding]; other site 164757012278 oxyanion hole (OAH) forming residues; other site 164757012279 trimer interface [polypeptide binding]; other site 164757012280 Predicted membrane protein [Function unknown]; Region: COG4425 164757012281 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 164757012282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757012283 active site residue [active] 164757012284 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 164757012285 hypothetical protein; Provisional; Region: PRK10279 164757012286 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 164757012287 active site 164757012288 nucleophile elbow; other site 164757012289 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 164757012290 nucleophile elbow; other site 164757012291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 164757012292 MOSC domain; Region: MOSC; pfam03473 164757012293 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757012294 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757012295 lipid-transfer protein; Provisional; Region: PRK08256 164757012296 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757012297 active site 164757012298 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 164757012299 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 164757012300 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 164757012301 PAS domain; Region: PAS; smart00091 164757012302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012303 ATP binding site [chemical binding]; other site 164757012304 Mg2+ binding site [ion binding]; other site 164757012305 G-X-G motif; other site 164757012306 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 164757012307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012308 active site 164757012309 phosphorylation site [posttranslational modification] 164757012310 intermolecular recognition site; other site 164757012311 dimerization interface [polypeptide binding]; other site 164757012312 Homeodomain-like domain; Region: HTH_23; pfam13384 164757012313 Uncharacterized conserved protein [Function unknown]; Region: COG3391 164757012314 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 164757012315 amidase catalytic site [active] 164757012316 Zn binding residues [ion binding]; other site 164757012317 substrate binding site [chemical binding]; other site 164757012318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 164757012319 Cupin domain; Region: Cupin_2; pfam07883 164757012320 Putative esterase; Region: Esterase; pfam00756 164757012321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 164757012322 Predicted transcriptional regulator [Transcription]; Region: COG2345 164757012323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757012324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757012325 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 164757012326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757012327 Walker A/P-loop; other site 164757012328 ATP binding site [chemical binding]; other site 164757012329 Q-loop/lid; other site 164757012330 ABC transporter signature motif; other site 164757012331 Walker B; other site 164757012332 D-loop; other site 164757012333 H-loop/switch region; other site 164757012334 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 164757012335 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 164757012336 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 164757012337 Cation efflux family; Region: Cation_efflux; cl00316 164757012338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757012339 dimerization interface [polypeptide binding]; other site 164757012340 putative DNA binding site [nucleotide binding]; other site 164757012341 putative Zn2+ binding site [ion binding]; other site 164757012342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 164757012343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 164757012344 Coenzyme A binding pocket [chemical binding]; other site 164757012345 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 164757012346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 164757012347 inhibitor-cofactor binding pocket; inhibition site 164757012348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012349 catalytic residue [active] 164757012350 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 164757012351 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 164757012352 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 164757012353 E-class dimer interface [polypeptide binding]; other site 164757012354 P-class dimer interface [polypeptide binding]; other site 164757012355 active site 164757012356 Cu2+ binding site [ion binding]; other site 164757012357 Zn2+ binding site [ion binding]; other site 164757012358 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 164757012359 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 164757012360 dimer interface [polypeptide binding]; other site 164757012361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012362 catalytic residue [active] 164757012363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 164757012364 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757012365 active site residue [active] 164757012366 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 164757012367 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 164757012368 Cl- selectivity filter; other site 164757012369 Cl- binding residues [ion binding]; other site 164757012370 pore gating glutamate residue; other site 164757012371 dimer interface [polypeptide binding]; other site 164757012372 H+/Cl- coupling transport residue; other site 164757012373 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757012374 Cytochrome P450; Region: p450; cl12078 164757012375 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 164757012376 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 164757012377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757012378 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757012379 hypothetical protein; Provisional; Region: PRK08317 164757012380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757012381 S-adenosylmethionine binding site [chemical binding]; other site 164757012382 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757012383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757012384 classical (c) SDRs; Region: SDR_c; cd05233 164757012385 NAD(P) binding site [chemical binding]; other site 164757012386 active site 164757012387 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 164757012388 active site 164757012389 diiron metal binding site [ion binding]; other site 164757012390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012392 Carboxylesterase family; Region: COesterase; pfam00135 164757012393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 164757012394 substrate binding pocket [chemical binding]; other site 164757012395 catalytic triad [active] 164757012396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757012397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 164757012398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757012399 salt bridge; other site 164757012400 non-specific DNA binding site [nucleotide binding]; other site 164757012401 sequence-specific DNA binding site [nucleotide binding]; other site 164757012402 Domain of unknown function (DUF385); Region: DUF385; cl04387 164757012403 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757012404 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 164757012405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757012406 active site 164757012407 DNA binding site [nucleotide binding] 164757012408 Int/Topo IB signature motif; other site 164757012409 Helix-turn-helix domain; Region: HTH_17; pfam12728 164757012410 Transposase; Region: HTH_Tnp_1; pfam01527 164757012411 HTH-like domain; Region: HTH_21; pfam13276 164757012412 Integrase core domain; Region: rve; pfam00665 164757012413 Integrase core domain; Region: rve_3; pfam13683 164757012414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757012415 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757012416 Walker A motif; other site 164757012417 ATP binding site [chemical binding]; other site 164757012418 Walker B motif; other site 164757012419 arginine finger; other site 164757012420 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 164757012421 active site 164757012422 catalytic triad [active] 164757012423 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757012424 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 164757012425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757012426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757012427 motif II; other site 164757012428 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757012429 putative homotetramer interface [polypeptide binding]; other site 164757012430 putative homodimer interface [polypeptide binding]; other site 164757012431 putative allosteric switch controlling residues; other site 164757012432 putative metal binding site [ion binding]; other site 164757012433 putative homodimer-homodimer interface [polypeptide binding]; other site 164757012434 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 164757012435 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 164757012436 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757012437 hydrolase; Region: PLN02578 164757012438 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 164757012439 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757012440 VirB8 protein; Region: VirB8; cl01500 164757012441 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012442 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012445 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 164757012446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757012447 S-adenosylmethionine binding site [chemical binding]; other site 164757012448 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 164757012449 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 164757012450 amidase catalytic site [active] 164757012451 Zn binding residues [ion binding]; other site 164757012452 substrate binding site [chemical binding]; other site 164757012453 LGFP repeat; Region: LGFP; pfam08310 164757012454 Domain of unknown function DUF302; Region: DUF302; pfam03625 164757012455 Penicillinase repressor; Region: Pencillinase_R; pfam03965 164757012456 CopC domain; Region: CopC; pfam04234 164757012457 Methyltransferase domain; Region: Methyltransf_11; pfam08241 164757012458 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 164757012459 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757012460 catalytic residues [active] 164757012461 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 164757012462 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 164757012463 Cupin domain; Region: Cupin_2; pfam07883 164757012464 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 164757012465 NADH dehydrogenase; Region: NADHdh; cl00469 164757012466 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 164757012467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757012468 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 164757012469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757012470 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 164757012471 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 164757012472 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 164757012473 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 164757012474 metal-binding site [ion binding] 164757012475 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 164757012476 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757012477 putative homodimer interface [polypeptide binding]; other site 164757012478 putative homotetramer interface [polypeptide binding]; other site 164757012479 putative allosteric switch controlling residues; other site 164757012480 putative metal binding site [ion binding]; other site 164757012481 putative homodimer-homodimer interface [polypeptide binding]; other site 164757012482 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 164757012483 dimerization interface [polypeptide binding]; other site 164757012484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757012485 active site residue [active] 164757012486 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 164757012487 Cupin domain; Region: Cupin_2; cl17218 164757012488 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757012489 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 164757012490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 164757012491 active site 164757012492 phosphorylation site [posttranslational modification] 164757012493 intermolecular recognition site; other site 164757012494 dimerization interface [polypeptide binding]; other site 164757012495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012496 DNA binding site [nucleotide binding] 164757012497 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 164757012498 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 164757012499 putative active site [active] 164757012500 catalytic triad [active] 164757012501 putative dimer interface [polypeptide binding]; other site 164757012502 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 164757012503 Peptidase family M23; Region: Peptidase_M23; pfam01551 164757012504 Predicted esterase [General function prediction only]; Region: COG0627 164757012505 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 164757012506 Peptidase family M48; Region: Peptidase_M48; cl12018 164757012507 Penicillinase repressor; Region: Pencillinase_R; pfam03965 164757012508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757012509 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757012510 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757012511 Penicillinase repressor; Region: Pencillinase_R; pfam03965 164757012512 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 164757012513 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757012514 catalytic residues [active] 164757012515 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012516 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012517 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 164757012518 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 164757012519 Multicopper oxidase; Region: Cu-oxidase; pfam00394 164757012520 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 164757012521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012522 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 164757012523 active site 164757012524 phosphorylation site [posttranslational modification] 164757012525 intermolecular recognition site; other site 164757012526 dimerization interface [polypeptide binding]; other site 164757012527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012528 DNA binding site [nucleotide binding] 164757012529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757012530 dimer interface [polypeptide binding]; other site 164757012531 phosphorylation site [posttranslational modification] 164757012532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012533 ATP binding site [chemical binding]; other site 164757012534 Mg2+ binding site [ion binding]; other site 164757012535 G-X-G motif; other site 164757012536 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 164757012537 Domain of unknown function (DUF305); Region: DUF305; pfam03713 164757012538 short chain dehydrogenase; Validated; Region: PRK05855 164757012539 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012540 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012541 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012542 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012543 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757012544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757012545 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 164757012546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757012547 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 164757012548 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757012549 cyclase homology domain; Region: CHD; cd07302 164757012550 nucleotidyl binding site; other site 164757012551 metal binding site [ion binding]; metal-binding site 164757012552 dimer interface [polypeptide binding]; other site 164757012553 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 164757012554 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 164757012555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757012556 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757012557 YceG-like family; Region: YceG; pfam02618 164757012558 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 164757012559 dimerization interface [polypeptide binding]; other site 164757012560 Hepcidin; Region: Hepcidin; pfam06446 164757012561 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 164757012562 RES domain; Region: RES; cl02411 164757012563 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 164757012564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757012565 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 164757012566 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 164757012567 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757012568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757012569 motif II; other site 164757012570 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757012571 putative homotetramer interface [polypeptide binding]; other site 164757012572 putative homodimer interface [polypeptide binding]; other site 164757012573 putative allosteric switch controlling residues; other site 164757012574 putative metal binding site [ion binding]; other site 164757012575 putative homodimer-homodimer interface [polypeptide binding]; other site 164757012576 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 164757012577 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 164757012578 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 164757012579 metal-binding site [ion binding] 164757012580 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757012581 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757012582 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 164757012583 metal-binding site [ion binding] 164757012584 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757012585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757012586 Helix-turn-helix domain; Region: HTH_18; pfam12833 164757012587 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 164757012588 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 164757012589 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 164757012590 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 164757012591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 164757012592 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 164757012593 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012594 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757012596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012597 DNA binding site [nucleotide binding] 164757012598 multidrug resistance protein MdtH; Provisional; Region: PRK11646 164757012599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012600 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 164757012601 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 164757012602 dimer interface [polypeptide binding]; other site 164757012603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757012604 catalytic residue [active] 164757012605 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 164757012606 Penicillinase repressor; Region: Pencillinase_R; pfam03965 164757012607 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012608 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757012610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012611 active site 164757012612 phosphorylation site [posttranslational modification] 164757012613 intermolecular recognition site; other site 164757012614 dimerization interface [polypeptide binding]; other site 164757012615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012616 DNA binding site [nucleotide binding] 164757012617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 164757012618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757012619 dimer interface [polypeptide binding]; other site 164757012620 phosphorylation site [posttranslational modification] 164757012621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012622 ATP binding site [chemical binding]; other site 164757012623 Mg2+ binding site [ion binding]; other site 164757012624 G-X-G motif; other site 164757012625 Domain of unknown function (DUF305); Region: DUF305; pfam03713 164757012626 BNR repeat-like domain; Region: BNR_2; pfam13088 164757012627 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 164757012628 NlpC/P60 family; Region: NLPC_P60; pfam00877 164757012629 RES domain; Region: RES; cl02411 164757012630 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 164757012631 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757012632 active site 164757012633 Int/Topo IB signature motif; other site 164757012634 DNA binding site [nucleotide binding] 164757012635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757012636 active site 164757012637 DNA binding site [nucleotide binding] 164757012638 Int/Topo IB signature motif; other site 164757012639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757012640 active site 164757012641 DNA binding site [nucleotide binding] 164757012642 Int/Topo IB signature motif; other site 164757012643 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757012644 DNA binding site [nucleotide binding] 164757012645 active site 164757012646 Int/Topo IB signature motif; other site 164757012647 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 164757012648 putative Zn-ribbon RNA-binding protein; Provisional; Region: PRK14890 164757012649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012651 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757012652 CoenzymeA binding site [chemical binding]; other site 164757012653 subunit interaction site [polypeptide binding]; other site 164757012654 PHB binding site; other site 164757012655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012657 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757012658 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 164757012659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012661 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757012662 Cytochrome P450; Region: p450; cl12078 164757012663 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757012664 CoenzymeA binding site [chemical binding]; other site 164757012665 subunit interaction site [polypeptide binding]; other site 164757012666 PHB binding site; other site 164757012667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757012668 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757012669 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 164757012670 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 164757012671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012673 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 164757012674 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 164757012675 AAA domain; Region: AAA_13; pfam13166 164757012676 HipA-like N-terminal domain; Region: HipA_N; pfam07805 164757012677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757012678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012679 putative substrate translocation pore; other site 164757012680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757012683 D-galactonate transporter; Region: 2A0114; TIGR00893 164757012684 putative substrate translocation pore; other site 164757012685 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 164757012686 homotrimer interaction site [polypeptide binding]; other site 164757012687 putative active site [active] 164757012688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 164757012689 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 164757012690 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 164757012691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757012692 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757012693 K+-transporting ATPase, c chain; Region: KdpC; cl00944 164757012694 K+-transporting ATPase, c chain; Region: KdpC; cl00944 164757012695 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 164757012696 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 164757012697 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 164757012698 Ligand Binding Site [chemical binding]; other site 164757012699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757012700 dimer interface [polypeptide binding]; other site 164757012701 phosphorylation site [posttranslational modification] 164757012702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012703 ATP binding site [chemical binding]; other site 164757012704 Mg2+ binding site [ion binding]; other site 164757012705 G-X-G motif; other site 164757012706 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 164757012707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012708 active site 164757012709 phosphorylation site [posttranslational modification] 164757012710 intermolecular recognition site; other site 164757012711 dimerization interface [polypeptide binding]; other site 164757012712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012713 DNA binding site [nucleotide binding] 164757012714 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 164757012715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757012716 acyl-activating enzyme (AAE) consensus motif; other site 164757012717 AMP binding site [chemical binding]; other site 164757012718 active site 164757012719 CoA binding site [chemical binding]; other site 164757012720 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757012721 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757012722 active site 164757012723 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 164757012724 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 164757012725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757012726 Radical SAM superfamily; Region: Radical_SAM; pfam04055 164757012727 FeS/SAM binding site; other site 164757012728 exopolyphosphatase; Region: exo_poly_only; TIGR03706 164757012729 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 164757012730 Uncharacterized conserved protein [Function unknown]; Region: COG1507 164757012731 Septum formation initiator; Region: DivIC; pfam04977 164757012732 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 164757012733 enolase; Provisional; Region: eno; PRK00077 164757012734 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 164757012735 dimer interface [polypeptide binding]; other site 164757012736 metal binding site [ion binding]; metal-binding site 164757012737 substrate binding pocket [chemical binding]; other site 164757012738 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 164757012739 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 164757012740 N-acetyl-D-glucosamine binding site [chemical binding]; other site 164757012741 Imelysin; Region: Peptidase_M75; pfam09375 164757012742 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 164757012743 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 164757012744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 164757012745 homodimer interface [polypeptide binding]; other site 164757012746 metal binding site [ion binding]; metal-binding site 164757012747 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 164757012748 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 164757012749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757012750 ATP binding site [chemical binding]; other site 164757012751 putative Mg++ binding site [ion binding]; other site 164757012752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757012753 nucleotide binding region [chemical binding]; other site 164757012754 ATP-binding site [chemical binding]; other site 164757012755 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 164757012756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757012757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757012758 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 164757012759 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 164757012760 Substrate binding site; other site 164757012761 Mg++ binding site; other site 164757012762 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 164757012763 active site 164757012764 substrate binding site [chemical binding]; other site 164757012765 CoA binding site [chemical binding]; other site 164757012766 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 164757012767 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 164757012768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757012769 active site 164757012770 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 164757012771 ArsC family; Region: ArsC; pfam03960 164757012772 catalytic residues [active] 164757012773 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 164757012774 short chain dehydrogenase; Provisional; Region: PRK06197 164757012775 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 164757012776 putative NAD(P) binding site [chemical binding]; other site 164757012777 active site 164757012778 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 164757012779 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 164757012780 5S rRNA interface [nucleotide binding]; other site 164757012781 CTC domain interface [polypeptide binding]; other site 164757012782 L16 interface [polypeptide binding]; other site 164757012783 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 164757012784 putative active site [active] 164757012785 catalytic residue [active] 164757012786 Protein of unknown function, DUF488; Region: DUF488; pfam04343 164757012787 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 164757012788 4Fe-4S binding domain; Region: Fer4; pfam00037 164757012789 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 164757012790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757012791 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757012792 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757012793 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757012794 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 164757012795 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 164757012796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757012797 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 164757012798 Walker A/P-loop; other site 164757012799 ATP binding site [chemical binding]; other site 164757012800 Q-loop/lid; other site 164757012801 ABC transporter signature motif; other site 164757012802 Walker B; other site 164757012803 D-loop; other site 164757012804 H-loop/switch region; other site 164757012805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 164757012806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757012807 acyl-activating enzyme (AAE) consensus motif; other site 164757012808 AMP binding site [chemical binding]; other site 164757012809 active site 164757012810 CoA binding site [chemical binding]; other site 164757012811 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 164757012812 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 164757012813 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 164757012814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757012815 S-adenosylmethionine binding site [chemical binding]; other site 164757012816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 164757012817 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757012818 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757012819 Domain of unknown function (DUF348); Region: DUF348; pfam03990 164757012820 G5 domain; Region: G5; pfam07501 164757012821 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757012822 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 164757012823 active site 164757012824 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 164757012825 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 164757012826 active site 164757012827 HIGH motif; other site 164757012828 KMSKS motif; other site 164757012829 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 164757012830 tRNA binding surface [nucleotide binding]; other site 164757012831 anticodon binding site; other site 164757012832 glutamate dehydrogenase; Provisional; Region: PRK09414 164757012833 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 164757012834 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 164757012835 NAD(P) binding site [chemical binding]; other site 164757012836 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 164757012837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757012838 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 164757012839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757012840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757012841 DNA binding residues [nucleotide binding] 164757012842 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757012843 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 164757012844 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 164757012845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757012846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757012847 DNA binding residues [nucleotide binding] 164757012848 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757012849 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 164757012850 chorismate binding enzyme; Region: Chorismate_bind; cl10555 164757012851 Predicted methyltransferases [General function prediction only]; Region: COG0313 164757012852 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 164757012853 putative SAM binding site [chemical binding]; other site 164757012854 putative homodimer interface [polypeptide binding]; other site 164757012855 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 164757012856 arginine deiminase; Provisional; Region: PRK01388 164757012857 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 164757012858 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 164757012859 DNA binding residues [nucleotide binding] 164757012860 dimer interface [polypeptide binding]; other site 164757012861 [2Fe-2S] cluster binding site [ion binding]; other site 164757012862 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 164757012863 PE-PPE domain; Region: PE-PPE; pfam08237 164757012864 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 164757012865 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 164757012866 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 164757012867 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 164757012868 shikimate binding site; other site 164757012869 NAD(P) binding site [chemical binding]; other site 164757012870 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 164757012871 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 164757012872 ligand binding site [chemical binding]; other site 164757012873 flexible hinge region; other site 164757012874 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 164757012875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 164757012876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 164757012877 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 164757012878 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 164757012879 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 164757012880 dimer interface [polypeptide binding]; other site 164757012881 putative functional site; other site 164757012882 putative MPT binding site; other site 164757012883 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 164757012884 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 164757012885 active site 164757012886 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 164757012887 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 164757012888 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 164757012889 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 164757012890 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 164757012891 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 164757012892 Homeodomain-like domain; Region: HTH_23; pfam13384 164757012893 Helix-turn-helix domain; Region: HTH_38; pfam13936 164757012894 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 164757012895 Integrase core domain; Region: rve; pfam00665 164757012896 MspA; Region: MspA; pfam09203 164757012897 MspA; Region: MspA; pfam09203 164757012898 Homeodomain-like domain; Region: HTH_23; pfam13384 164757012899 Helix-turn-helix domain; Region: HTH_38; pfam13936 164757012900 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 164757012901 Integrase core domain; Region: rve; pfam00665 164757012902 MspA; Region: MspA; pfam09203 164757012903 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 164757012904 MPT binding site; other site 164757012905 trimer interface [polypeptide binding]; other site 164757012906 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757012907 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 164757012908 protein binding site [polypeptide binding]; other site 164757012909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757012910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757012911 dimerization interface [polypeptide binding]; other site 164757012912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757012913 dimer interface [polypeptide binding]; other site 164757012914 phosphorylation site [posttranslational modification] 164757012915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757012916 ATP binding site [chemical binding]; other site 164757012917 Mg2+ binding site [ion binding]; other site 164757012918 G-X-G motif; other site 164757012919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757012920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757012921 active site 164757012922 phosphorylation site [posttranslational modification] 164757012923 intermolecular recognition site; other site 164757012924 dimerization interface [polypeptide binding]; other site 164757012925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757012926 DNA binding site [nucleotide binding] 164757012927 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 164757012928 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 164757012929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757012930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757012931 active site 164757012932 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757012933 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757012934 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757012935 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 164757012936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 164757012937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 164757012938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 164757012939 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 164757012940 carboxyltransferase (CT) interaction site; other site 164757012941 biotinylation site [posttranslational modification]; other site 164757012942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757012943 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757012944 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757012945 active site 164757012946 enoyl-CoA hydratase; Provisional; Region: PRK07827 164757012947 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757012948 substrate binding site [chemical binding]; other site 164757012949 oxyanion hole (OAH) forming residues; other site 164757012950 trimer interface [polypeptide binding]; other site 164757012951 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 164757012952 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 164757012953 PE-PPE domain; Region: PE-PPE; pfam08237 164757012954 PE-PPE domain; Region: PE-PPE; pfam08237 164757012955 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 164757012956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 164757012957 metal ion-dependent adhesion site (MIDAS); other site 164757012958 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 164757012959 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 164757012960 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 164757012961 Sulfate transporter family; Region: Sulfate_transp; pfam00916 164757012962 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 164757012963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757012964 dimerization interface [polypeptide binding]; other site 164757012965 putative DNA binding site [nucleotide binding]; other site 164757012966 putative Zn2+ binding site [ion binding]; other site 164757012967 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757012968 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757012969 active site 164757012970 ATP binding site [chemical binding]; other site 164757012971 substrate binding site [chemical binding]; other site 164757012972 activation loop (A-loop); other site 164757012973 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 164757012974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757012975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757012976 metal binding site [ion binding]; metal-binding site 164757012977 active site 164757012978 I-site; other site 164757012979 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 164757012980 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 164757012981 purine monophosphate binding site [chemical binding]; other site 164757012982 dimer interface [polypeptide binding]; other site 164757012983 putative catalytic residues [active] 164757012984 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 164757012985 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 164757012986 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 164757012987 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 164757012988 active site 164757012989 cosubstrate binding site; other site 164757012990 substrate binding site [chemical binding]; other site 164757012991 catalytic site [active] 164757012992 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 164757012993 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 164757012994 active site 164757012995 dimer interface [polypeptide binding]; other site 164757012996 non-prolyl cis peptide bond; other site 164757012997 insertion regions; other site 164757012998 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757012999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757013000 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 164757013001 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 164757013002 active site 164757013003 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 164757013004 CoA binding domain; Region: CoA_binding; smart00881 164757013005 CoA-ligase; Region: Ligase_CoA; pfam00549 164757013006 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 164757013007 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 164757013008 CoA-ligase; Region: Ligase_CoA; pfam00549 164757013009 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 164757013010 Peptidase family M23; Region: Peptidase_M23; pfam01551 164757013011 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 164757013012 Part of AAA domain; Region: AAA_19; pfam13245 164757013013 Family description; Region: UvrD_C_2; pfam13538 164757013014 hypothetical protein; Provisional; Region: PRK07857 164757013015 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 164757013016 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 164757013017 active site 164757013018 catalytic triad [active] 164757013019 oxyanion hole [active] 164757013020 succinic semialdehyde dehydrogenase; Region: PLN02278 164757013021 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 164757013022 tetramerization interface [polypeptide binding]; other site 164757013023 NAD(P) binding site [chemical binding]; other site 164757013024 catalytic residues [active] 164757013025 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 164757013026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 164757013027 active site 164757013028 dimer interface [polypeptide binding]; other site 164757013029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 164757013030 dimer interface [polypeptide binding]; other site 164757013031 active site 164757013032 short chain dehydrogenase; Provisional; Region: PRK08251 164757013033 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 164757013034 putative NAD(P) binding site [chemical binding]; other site 164757013035 active site 164757013036 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 164757013037 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 164757013038 putative DNA binding site [nucleotide binding]; other site 164757013039 catalytic residue [active] 164757013040 putative H2TH interface [polypeptide binding]; other site 164757013041 putative catalytic residues [active] 164757013042 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 164757013043 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 164757013044 Predicted membrane protein [Function unknown]; Region: COG1950 164757013045 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 164757013046 active site 164757013047 SAM binding site [chemical binding]; other site 164757013048 homodimer interface [polypeptide binding]; other site 164757013049 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 164757013050 thiamine pyrophosphate protein; Provisional; Region: PRK08273 164757013051 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 164757013052 PYR/PP interface [polypeptide binding]; other site 164757013053 dimer interface [polypeptide binding]; other site 164757013054 tetramer interface [polypeptide binding]; other site 164757013055 TPP binding site [chemical binding]; other site 164757013056 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 164757013057 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 164757013058 TPP-binding site [chemical binding]; other site 164757013059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757013060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757013061 putative substrate translocation pore; other site 164757013062 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 164757013063 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757013064 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757013065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757013066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757013067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757013068 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 164757013069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013070 NAD(P) binding site [chemical binding]; other site 164757013071 active site 164757013072 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 164757013073 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 164757013074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 164757013075 phosphopeptide binding site; other site 164757013076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757013077 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 164757013078 DNA binding residues [nucleotide binding] 164757013079 dimerization interface [polypeptide binding]; other site 164757013080 Protein kinase domain; Region: Pkinase; pfam00069 164757013081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757013082 active site 164757013083 ATP binding site [chemical binding]; other site 164757013084 substrate binding site [chemical binding]; other site 164757013085 activation loop (A-loop); other site 164757013086 Kelch motif; Region: Kelch_6; pfam13964 164757013087 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 164757013088 Kelch domain; Region: Kelch; smart00612 164757013089 Kelch motif; Region: Kelch_1; pfam01344 164757013090 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 164757013091 Kelch motif; Region: Kelch_1; pfam01344 164757013092 Kelch domain; Region: Kelch; smart00612 164757013093 Kelch motif; Region: Kelch_1; pfam01344 164757013094 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 164757013095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 164757013096 active site 164757013097 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 164757013098 RNA/DNA hybrid binding site [nucleotide binding]; other site 164757013099 active site 164757013100 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757013101 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757013102 active site 164757013103 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 164757013104 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 164757013105 nucleotide binding site [chemical binding]; other site 164757013106 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 164757013107 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 164757013108 active site 164757013109 DNA binding site [nucleotide binding] 164757013110 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 164757013111 DNA binding site [nucleotide binding] 164757013112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 164757013113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 164757013114 Walker A/P-loop; other site 164757013115 ATP binding site [chemical binding]; other site 164757013116 Q-loop/lid; other site 164757013117 ABC transporter signature motif; other site 164757013118 Walker B; other site 164757013119 D-loop; other site 164757013120 H-loop/switch region; other site 164757013121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 164757013122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757013123 dimer interface [polypeptide binding]; other site 164757013124 conserved gate region; other site 164757013125 putative PBP binding loops; other site 164757013126 ABC-ATPase subunit interface; other site 164757013127 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 164757013128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757013129 dimer interface [polypeptide binding]; other site 164757013130 putative PBP binding loops; other site 164757013131 ABC-ATPase subunit interface; other site 164757013132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 164757013133 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 164757013134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 164757013135 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 164757013136 MarR family; Region: MarR_2; pfam12802 164757013137 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 164757013138 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 164757013139 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 164757013140 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 164757013141 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 164757013142 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 164757013143 putative substrate binding site [chemical binding]; other site 164757013144 putative ATP binding site [chemical binding]; other site 164757013145 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 164757013146 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 164757013147 putative DNA binding site [nucleotide binding]; other site 164757013148 putative homodimer interface [polypeptide binding]; other site 164757013149 short chain dehydrogenase; Provisional; Region: PRK07814 164757013150 classical (c) SDRs; Region: SDR_c; cd05233 164757013151 NAD(P) binding site [chemical binding]; other site 164757013152 active site 164757013153 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757013154 manganese transport protein MntH; Reviewed; Region: PRK00701 164757013155 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 164757013156 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 164757013157 putative active site pocket [active] 164757013158 dimerization interface [polypeptide binding]; other site 164757013159 putative catalytic residue [active] 164757013160 Protein of unknown function (DUF867); Region: DUF867; pfam05908 164757013161 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 164757013162 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 164757013163 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 164757013164 active site 164757013165 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 164757013166 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 164757013167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757013168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757013169 DNA binding residues [nucleotide binding] 164757013170 putative anti-sigmaE protein; Provisional; Region: PRK13920 164757013171 Anti-sigma-K factor rskA; Region: RskA; pfam10099 164757013172 carboxylate-amine ligase; Provisional; Region: PRK13517 164757013173 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 164757013174 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 164757013175 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 164757013176 Subunit I/III interface [polypeptide binding]; other site 164757013177 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757013178 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 164757013179 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 164757013180 putative dimer interface [polypeptide binding]; other site 164757013181 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 164757013182 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 164757013183 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757013184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757013185 DNA-binding site [nucleotide binding]; DNA binding site 164757013186 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 164757013187 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 164757013188 Cysteine-rich domain; Region: CCG; pfam02754 164757013189 Cysteine-rich domain; Region: CCG; pfam02754 164757013190 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 164757013191 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 164757013192 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 164757013193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 164757013194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 164757013195 DNA binding site [nucleotide binding] 164757013196 domain linker motif; other site 164757013197 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 164757013198 ligand binding site [chemical binding]; other site 164757013199 dimerization interface [polypeptide binding]; other site 164757013200 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 164757013201 N- and C-terminal domain interface [polypeptide binding]; other site 164757013202 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 164757013203 active site 164757013204 putative catalytic site [active] 164757013205 metal binding site [ion binding]; metal-binding site 164757013206 ATP binding site [chemical binding]; other site 164757013207 carbohydrate binding site [chemical binding]; other site 164757013208 short chain dehydrogenase; Validated; Region: PRK08324 164757013209 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 164757013210 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 164757013211 putative NAD(P) binding site [chemical binding]; other site 164757013212 active site 164757013213 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 164757013214 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 164757013215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757013216 putative substrate translocation pore; other site 164757013217 Domain of unknown function (DUF718); Region: DUF718; pfam05336 164757013218 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 164757013219 active site 164757013220 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 164757013221 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757013222 NAD binding site [chemical binding]; other site 164757013223 catalytic residues [active] 164757013224 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 164757013225 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 164757013226 PYR/PP interface [polypeptide binding]; other site 164757013227 dimer interface [polypeptide binding]; other site 164757013228 TPP binding site [chemical binding]; other site 164757013229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 164757013230 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 164757013231 TPP-binding site; other site 164757013232 dimer interface [polypeptide binding]; other site 164757013233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013234 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757013235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757013236 active site 164757013237 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757013239 active site 164757013240 enoyl-CoA hydratase; Provisional; Region: PRK06688 164757013241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757013242 substrate binding site [chemical binding]; other site 164757013243 oxyanion hole (OAH) forming residues; other site 164757013244 trimer interface [polypeptide binding]; other site 164757013245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 164757013246 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 164757013247 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 164757013248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757013249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757013251 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013252 active site 164757013253 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757013254 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757013255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013256 NAD(P) binding site [chemical binding]; other site 164757013257 active site 164757013258 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757013259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757013260 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757013261 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 164757013262 [2Fe-2S] cluster binding site [ion binding]; other site 164757013263 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 164757013264 hydrophobic ligand binding site; other site 164757013265 classical (c) SDRs; Region: SDR_c; cd05233 164757013266 NAD(P) binding site [chemical binding]; other site 164757013267 active site 164757013268 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 164757013269 PQQ-like domain; Region: PQQ_2; pfam13360 164757013270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 164757013271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757013272 DNA-binding site [nucleotide binding]; DNA binding site 164757013273 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 164757013274 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 164757013275 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 164757013276 acyl-activating enzyme (AAE) consensus motif; other site 164757013277 putative AMP binding site [chemical binding]; other site 164757013278 putative active site [active] 164757013279 putative CoA binding site [chemical binding]; other site 164757013280 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 164757013281 classical (c) SDRs; Region: SDR_c; cd05233 164757013282 NAD(P) binding site [chemical binding]; other site 164757013283 active site 164757013284 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757013285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013286 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757013287 acyl-activating enzyme (AAE) consensus motif; other site 164757013288 acyl-activating enzyme (AAE) consensus motif; other site 164757013289 putative AMP binding site [chemical binding]; other site 164757013290 putative active site [active] 164757013291 putative CoA binding site [chemical binding]; other site 164757013292 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757013293 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757013294 short chain dehydrogenase; Provisional; Region: PRK07814 164757013295 classical (c) SDRs; Region: SDR_c; cd05233 164757013296 NAD(P) binding site [chemical binding]; other site 164757013297 active site 164757013298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 164757013300 metal ion-dependent adhesion site (MIDAS); other site 164757013301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757013302 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 164757013303 Walker A motif; other site 164757013304 ATP binding site [chemical binding]; other site 164757013305 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 164757013306 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757013307 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757013308 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013309 Cytochrome P450; Region: p450; cl12078 164757013310 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 164757013311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 164757013312 NAD(P) binding site [chemical binding]; other site 164757013313 putative active site [active] 164757013314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757013315 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 164757013316 catalytic site [active] 164757013317 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757013318 hydrophobic ligand binding site; other site 164757013319 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 164757013320 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 164757013321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757013322 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757013323 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757013324 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757013325 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 164757013326 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 164757013327 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 164757013328 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 164757013329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757013330 substrate binding site [chemical binding]; other site 164757013331 oxyanion hole (OAH) forming residues; other site 164757013332 trimer interface [polypeptide binding]; other site 164757013333 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 164757013334 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 164757013335 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 164757013336 AMP-binding domain protein; Validated; Region: PRK08315 164757013337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013338 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 164757013339 acyl-activating enzyme (AAE) consensus motif; other site 164757013340 acyl-activating enzyme (AAE) consensus motif; other site 164757013341 putative AMP binding site [chemical binding]; other site 164757013342 putative active site [active] 164757013343 putative CoA binding site [chemical binding]; other site 164757013344 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 164757013345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013346 acyl-activating enzyme (AAE) consensus motif; other site 164757013347 AMP binding site [chemical binding]; other site 164757013348 active site 164757013349 CoA binding site [chemical binding]; other site 164757013350 GAF domain; Region: GAF; pfam01590 164757013351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757013352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757013353 DNA binding residues [nucleotide binding] 164757013354 dimerization interface [polypeptide binding]; other site 164757013355 Epoxide hydrolase N terminus; Region: EHN; pfam06441 164757013356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757013357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757013358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757013359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757013360 metal binding site [ion binding]; metal-binding site 164757013361 active site 164757013362 I-site; other site 164757013363 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 164757013364 putative active site [active] 164757013365 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 164757013366 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 164757013367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 164757013368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757013369 Walker A/P-loop; other site 164757013370 ATP binding site [chemical binding]; other site 164757013371 Q-loop/lid; other site 164757013372 ABC transporter signature motif; other site 164757013373 Walker B; other site 164757013374 D-loop; other site 164757013375 H-loop/switch region; other site 164757013376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 164757013377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 164757013378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757013379 Walker A/P-loop; other site 164757013380 ATP binding site [chemical binding]; other site 164757013381 Q-loop/lid; other site 164757013382 ABC transporter signature motif; other site 164757013383 Walker B; other site 164757013384 D-loop; other site 164757013385 H-loop/switch region; other site 164757013386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 164757013387 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757013388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757013389 Walker A/P-loop; other site 164757013390 ATP binding site [chemical binding]; other site 164757013391 Q-loop/lid; other site 164757013392 ABC transporter signature motif; other site 164757013393 Walker B; other site 164757013394 D-loop; other site 164757013395 H-loop/switch region; other site 164757013396 Ion channel; Region: Ion_trans_2; pfam07885 164757013397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757013398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757013399 active site 164757013400 phosphorylation site [posttranslational modification] 164757013401 intermolecular recognition site; other site 164757013402 dimerization interface [polypeptide binding]; other site 164757013403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757013404 DNA binding site [nucleotide binding] 164757013405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757013406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757013407 dimerization interface [polypeptide binding]; other site 164757013408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757013409 dimer interface [polypeptide binding]; other site 164757013410 phosphorylation site [posttranslational modification] 164757013411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757013412 ATP binding site [chemical binding]; other site 164757013413 Mg2+ binding site [ion binding]; other site 164757013414 G-X-G motif; other site 164757013415 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 164757013416 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 164757013417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757013418 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 164757013419 MarR family; Region: MarR_2; cl17246 164757013420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757013421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757013422 putative substrate translocation pore; other site 164757013423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757013424 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 164757013425 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 164757013426 dimer interface [polypeptide binding]; other site 164757013427 active site 164757013428 citrylCoA binding site [chemical binding]; other site 164757013429 NADH binding [chemical binding]; other site 164757013430 cationic pore residues; other site 164757013431 oxalacetate/citrate binding site [chemical binding]; other site 164757013432 coenzyme A binding site [chemical binding]; other site 164757013433 catalytic triad [active] 164757013434 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 164757013435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013436 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 164757013437 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 164757013438 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 164757013439 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 164757013440 dimer interface [polypeptide binding]; other site 164757013441 Citrate synthase; Region: Citrate_synt; pfam00285 164757013442 active site 164757013443 citrylCoA binding site [chemical binding]; other site 164757013444 oxalacetate/citrate binding site [chemical binding]; other site 164757013445 coenzyme A binding site [chemical binding]; other site 164757013446 catalytic triad [active] 164757013447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 164757013448 putative dimer interface [polypeptide binding]; other site 164757013449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757013450 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757013451 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 164757013452 4Fe-4S binding domain; Region: Fer4; pfam00037 164757013453 ferredoxin-NADP+ reductase; Region: PLN02852 164757013454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757013455 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 164757013456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757013457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757013458 catalytic residue [active] 164757013459 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 164757013460 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 164757013461 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 164757013462 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 164757013463 MarR family; Region: MarR_2; cl17246 164757013464 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 164757013465 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757013466 hydrophobic ligand binding site; other site 164757013467 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 164757013468 H+ Antiporter protein; Region: 2A0121; TIGR00900 164757013469 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 164757013470 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 164757013471 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 164757013472 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 164757013473 putative dimer interface [polypeptide binding]; other site 164757013474 N-terminal domain interface [polypeptide binding]; other site 164757013475 putative substrate binding pocket (H-site) [chemical binding]; other site 164757013476 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 164757013477 DNA-binding site [nucleotide binding]; DNA binding site 164757013478 RNA-binding motif; other site 164757013479 hypothetical protein; Provisional; Region: PRK11770 164757013480 Domain of unknown function (DUF307); Region: DUF307; pfam03733 164757013481 Domain of unknown function (DUF307); Region: DUF307; pfam03733 164757013482 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 164757013483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 164757013484 FeS/SAM binding site; other site 164757013485 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 164757013486 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 164757013487 MoaE interaction surface [polypeptide binding]; other site 164757013488 thiocarboxylated glycine; other site 164757013489 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 164757013490 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 164757013491 MoaE homodimer interface [polypeptide binding]; other site 164757013492 MoaD interaction [polypeptide binding]; other site 164757013493 active site residues [active] 164757013494 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 164757013495 MPT binding site; other site 164757013496 trimer interface [polypeptide binding]; other site 164757013497 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 164757013498 trimer interface [polypeptide binding]; other site 164757013499 dimer interface [polypeptide binding]; other site 164757013500 putative active site [active] 164757013501 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 164757013502 WYL domain; Region: WYL; pfam13280 164757013503 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 164757013504 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 164757013505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 164757013506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757013507 ATP binding site [chemical binding]; other site 164757013508 putative Mg++ binding site [ion binding]; other site 164757013509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757013510 nucleotide binding region [chemical binding]; other site 164757013511 ATP-binding site [chemical binding]; other site 164757013512 ethanolamine permease; Region: 2A0305; TIGR00908 164757013513 Cupin domain; Region: Cupin_2; cl17218 164757013514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757013515 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757013516 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757013517 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 164757013518 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013519 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013520 AMP binding site [chemical binding]; other site 164757013521 active site 164757013522 acyl-activating enzyme (AAE) consensus motif; other site 164757013523 acyl-activating enzyme (AAE) consensus motif; other site 164757013524 CoA binding site [chemical binding]; other site 164757013525 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 164757013526 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757013527 substrate binding site [chemical binding]; other site 164757013528 oxyanion hole (OAH) forming residues; other site 164757013529 trimer interface [polypeptide binding]; other site 164757013530 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 164757013531 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 164757013532 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 164757013533 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757013534 dimer interface [polypeptide binding]; other site 164757013535 active site 164757013536 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 164757013537 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 164757013538 FMN binding site [chemical binding]; other site 164757013539 active site 164757013540 substrate binding site [chemical binding]; other site 164757013541 catalytic residue [active] 164757013542 short chain dehydrogenase; Validated; Region: PRK08264 164757013543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013544 NAD(P) binding site [chemical binding]; other site 164757013545 active site 164757013546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013548 aminotransferase; Validated; Region: PRK07777 164757013549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757013550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757013551 homodimer interface [polypeptide binding]; other site 164757013552 catalytic residue [active] 164757013553 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757013554 putative hydrophobic ligand binding site [chemical binding]; other site 164757013555 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757013556 putative hydrophobic ligand binding site [chemical binding]; other site 164757013557 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757013558 putative hydrophobic ligand binding site [chemical binding]; other site 164757013559 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 164757013560 putative hydrophobic ligand binding site [chemical binding]; other site 164757013561 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 164757013562 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 164757013563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013564 NAD(P) binding site [chemical binding]; other site 164757013565 active site 164757013566 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757013567 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757013568 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 164757013569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757013570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013574 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 164757013575 apolar tunnel; other site 164757013576 heme binding site [chemical binding]; other site 164757013577 dimerization interface [polypeptide binding]; other site 164757013578 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 164757013579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013581 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 164757013582 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 164757013583 homodimer interface [polypeptide binding]; other site 164757013584 putative substrate binding pocket [chemical binding]; other site 164757013585 diiron center [ion binding]; other site 164757013586 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 164757013587 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 164757013588 FMN binding site [chemical binding]; other site 164757013589 active site 164757013590 catalytic residues [active] 164757013591 substrate binding site [chemical binding]; other site 164757013592 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 164757013593 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 164757013594 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 164757013595 PhoU domain; Region: PhoU; pfam01895 164757013596 PhoU domain; Region: PhoU; pfam01895 164757013597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757013598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757013599 active site 164757013600 phosphorylation site [posttranslational modification] 164757013601 intermolecular recognition site; other site 164757013602 dimerization interface [polypeptide binding]; other site 164757013603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757013604 DNA binding site [nucleotide binding] 164757013605 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 164757013606 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 164757013607 Walker A/P-loop; other site 164757013608 ATP binding site [chemical binding]; other site 164757013609 Q-loop/lid; other site 164757013610 ABC transporter signature motif; other site 164757013611 Walker B; other site 164757013612 D-loop; other site 164757013613 H-loop/switch region; other site 164757013614 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 164757013615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757013616 dimer interface [polypeptide binding]; other site 164757013617 conserved gate region; other site 164757013618 putative PBP binding loops; other site 164757013619 ABC-ATPase subunit interface; other site 164757013620 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 164757013621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757013622 dimer interface [polypeptide binding]; other site 164757013623 conserved gate region; other site 164757013624 ABC-ATPase subunit interface; other site 164757013625 PBP superfamily domain; Region: PBP_like_2; cl17296 164757013626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757013627 putative DNA binding site [nucleotide binding]; other site 164757013628 putative Zn2+ binding site [ion binding]; other site 164757013629 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 164757013630 Low molecular weight phosphatase family; Region: LMWPc; cl00105 164757013631 active site 164757013632 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 164757013633 Low molecular weight phosphatase family; Region: LMWPc; cd00115 164757013634 active site 164757013635 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 164757013636 arsenical-resistance protein; Region: acr3; TIGR00832 164757013637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757013638 dimerization interface [polypeptide binding]; other site 164757013639 putative DNA binding site [nucleotide binding]; other site 164757013640 putative Zn2+ binding site [ion binding]; other site 164757013641 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 164757013642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 164757013643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757013644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757013645 DNA binding site [nucleotide binding] 164757013646 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 164757013647 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 164757013648 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757013649 catalytic residues [active] 164757013650 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 164757013651 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 164757013652 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 164757013653 active site residue [active] 164757013654 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 164757013655 active site residue [active] 164757013656 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 164757013657 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757013658 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 164757013659 heme-binding site [chemical binding]; other site 164757013660 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 164757013661 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 164757013662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757013663 catalytic residue [active] 164757013664 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 164757013665 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 164757013666 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 164757013667 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 164757013668 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 164757013669 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 164757013670 dimerization interface [polypeptide binding]; other site 164757013671 putative ATP binding site [chemical binding]; other site 164757013672 Cupin domain; Region: Cupin_2; cl17218 164757013673 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 164757013674 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 164757013675 putative NAD(P) binding site [chemical binding]; other site 164757013676 putative active site [active] 164757013677 amidophosphoribosyltransferase; Provisional; Region: PRK07847 164757013678 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 164757013679 active site 164757013680 tetramer interface [polypeptide binding]; other site 164757013681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757013682 active site 164757013683 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013684 mce related protein; Region: MCE; pfam02470 164757013685 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757013686 CAAX protease self-immunity; Region: Abi; pfam02517 164757013687 Predicted membrane protein [Function unknown]; Region: COG4425 164757013688 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 164757013689 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 164757013690 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 164757013691 dimerization interface [polypeptide binding]; other site 164757013692 ATP binding site [chemical binding]; other site 164757013693 Uncharacterized conserved protein [Function unknown]; Region: COG3375 164757013694 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 164757013695 dimerization interface [polypeptide binding]; other site 164757013696 ATP binding site [chemical binding]; other site 164757013697 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 164757013698 PE-PPE domain; Region: PE-PPE; pfam08237 164757013699 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757013700 active site 164757013701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757013702 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 164757013703 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 164757013704 active site 164757013705 metal binding site [ion binding]; metal-binding site 164757013706 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 164757013707 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 164757013708 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 164757013709 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 164757013710 putative active site [active] 164757013711 catalytic triad [active] 164757013712 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 164757013713 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 164757013714 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757013715 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 164757013716 Predicted deacetylase [General function prediction only]; Region: COG3233 164757013717 putative active site [active] 164757013718 putative Zn binding site [ion binding]; other site 164757013719 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 164757013720 catalytic residues [active] 164757013721 dimer interface [polypeptide binding]; other site 164757013722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757013724 WHG domain; Region: WHG; pfam13305 164757013725 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 164757013726 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 164757013727 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 164757013728 ATP binding site [chemical binding]; other site 164757013729 active site 164757013730 substrate binding site [chemical binding]; other site 164757013731 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 164757013732 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 164757013733 DXD motif; other site 164757013734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013735 NAD(P) binding site [chemical binding]; other site 164757013736 active site 164757013737 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013738 Cytochrome P450; Region: p450; cl12078 164757013739 adenylosuccinate lyase; Region: purB; TIGR00928 164757013740 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 164757013741 tetramer interface [polypeptide binding]; other site 164757013742 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 164757013743 amino acid transporter; Region: 2A0306; TIGR00909 164757013744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 164757013745 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 164757013746 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 164757013747 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 164757013748 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 164757013749 Cytochrome P450; Region: p450; cl12078 164757013750 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757013752 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 164757013753 DNA-binding interface [nucleotide binding]; DNA binding site 164757013754 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 164757013755 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 164757013756 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757013757 short chain dehydrogenase; Provisional; Region: PRK07774 164757013758 classical (c) SDRs; Region: SDR_c; cd05233 164757013759 NAD(P) binding site [chemical binding]; other site 164757013760 active site 164757013761 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 164757013762 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 164757013763 NAD binding site [chemical binding]; other site 164757013764 catalytic residues [active] 164757013765 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013766 Cytochrome P450; Region: p450; cl12078 164757013767 short chain dehydrogenase; Provisional; Region: PRK07775 164757013768 classical (c) SDRs; Region: SDR_c; cd05233 164757013769 NAD(P) binding site [chemical binding]; other site 164757013770 active site 164757013771 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013772 Cytochrome P450; Region: p450; cl12078 164757013773 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757013774 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757013775 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757013776 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757013777 NAD binding site [chemical binding]; other site 164757013778 catalytic Zn binding site [ion binding]; other site 164757013779 substrate binding site [chemical binding]; other site 164757013780 structural Zn binding site [ion binding]; other site 164757013781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757013782 classical (c) SDRs; Region: SDR_c; cd05233 164757013783 NAD(P) binding site [chemical binding]; other site 164757013784 active site 164757013785 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 164757013786 nucleotide binding site/active site [active] 164757013787 HIT family signature motif; other site 164757013788 catalytic residue [active] 164757013789 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757013790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 164757013791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 164757013792 dimer interface [polypeptide binding]; other site 164757013793 phosphorylation site [posttranslational modification] 164757013794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757013795 ATP binding site [chemical binding]; other site 164757013796 Mg2+ binding site [ion binding]; other site 164757013797 G-X-G motif; other site 164757013798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 164757013799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757013800 active site 164757013801 phosphorylation site [posttranslational modification] 164757013802 intermolecular recognition site; other site 164757013803 dimerization interface [polypeptide binding]; other site 164757013804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 164757013805 DNA binding site [nucleotide binding] 164757013806 HNH endonuclease; Region: HNH_3; pfam13392 164757013807 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 164757013808 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757013809 trehalose synthase; Region: treS_nterm; TIGR02456 164757013810 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 164757013811 active site 164757013812 catalytic site [active] 164757013813 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 164757013814 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 164757013815 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 164757013816 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 164757013817 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 164757013818 putative hydrophobic ligand binding site [chemical binding]; other site 164757013819 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 164757013820 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 164757013821 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 164757013822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757013823 catalytic loop [active] 164757013824 iron binding site [ion binding]; other site 164757013825 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 164757013826 short chain dehydrogenase; Provisional; Region: PRK05875 164757013827 classical (c) SDRs; Region: SDR_c; cd05233 164757013828 NAD(P) binding site [chemical binding]; other site 164757013829 active site 164757013830 enoyl-CoA hydratase; Provisional; Region: PRK08290 164757013831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757013832 substrate binding site [chemical binding]; other site 164757013833 oxyanion hole (OAH) forming residues; other site 164757013834 trimer interface [polypeptide binding]; other site 164757013835 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 164757013836 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 164757013837 active site 164757013838 homotetramer interface [polypeptide binding]; other site 164757013839 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013840 mce related protein; Region: MCE; pfam02470 164757013841 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013842 mce related protein; Region: MCE; pfam02470 164757013843 mce related protein; Region: MCE; pfam02470 164757013844 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757013845 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013846 mce related protein; Region: MCE; pfam02470 164757013847 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013848 mce related protein; Region: MCE; pfam02470 164757013849 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757013850 mce related protein; Region: MCE; pfam02470 164757013851 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757013852 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757013853 Permease; Region: Permease; pfam02405 164757013854 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 164757013855 Permease; Region: Permease; pfam02405 164757013856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013857 NAD(P) binding site [chemical binding]; other site 164757013858 flagellin modification protein A; Provisional; Region: PRK09186 164757013859 active site 164757013860 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 164757013861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013862 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 164757013863 FAD binding site [chemical binding]; other site 164757013864 substrate binding site [chemical binding]; other site 164757013865 catalytic base [active] 164757013866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757013867 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757013868 active site 164757013869 acyl-CoA synthetase; Validated; Region: PRK07867 164757013870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013871 acyl-activating enzyme (AAE) consensus motif; other site 164757013872 AMP binding site [chemical binding]; other site 164757013873 active site 164757013874 CoA binding site [chemical binding]; other site 164757013875 Nitronate monooxygenase; Region: NMO; pfam03060 164757013876 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757013877 FMN binding site [chemical binding]; other site 164757013878 substrate binding site [chemical binding]; other site 164757013879 putative catalytic residue [active] 164757013880 acyl-CoA synthetase; Validated; Region: PRK07798 164757013881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013882 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 164757013883 acyl-activating enzyme (AAE) consensus motif; other site 164757013884 acyl-activating enzyme (AAE) consensus motif; other site 164757013885 putative AMP binding site [chemical binding]; other site 164757013886 putative active site [active] 164757013887 putative CoA binding site [chemical binding]; other site 164757013888 enoyl-CoA hydratase; Provisional; Region: PRK07799 164757013889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757013890 substrate binding site [chemical binding]; other site 164757013891 oxyanion hole (OAH) forming residues; other site 164757013892 trimer interface [polypeptide binding]; other site 164757013893 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 164757013894 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013895 Cytochrome P450; Region: p450; cl12078 164757013896 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 164757013897 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757013898 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 164757013899 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757013900 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757013901 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757013902 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757013903 lipid-transfer protein; Provisional; Region: PRK07937 164757013904 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757013905 active site 164757013906 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 164757013907 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757013908 active site 164757013909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757013910 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757013911 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 164757013912 MOSC domain; Region: MOSC; pfam03473 164757013913 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 164757013914 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 164757013915 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 164757013916 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 164757013917 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 164757013918 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 164757013919 DXD motif; other site 164757013920 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 164757013921 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 164757013922 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 164757013923 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 164757013924 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 164757013925 short chain dehydrogenase; Provisional; Region: PRK07890 164757013926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757013927 NAD(P) binding site [chemical binding]; other site 164757013928 active site 164757013929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757013930 putative DNA binding site [nucleotide binding]; other site 164757013931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 164757013932 putative Zn2+ binding site [ion binding]; other site 164757013933 acyl-CoA synthetase; Provisional; Region: PRK13390 164757013934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757013935 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 164757013936 acyl-activating enzyme (AAE) consensus motif; other site 164757013937 putative AMP binding site [chemical binding]; other site 164757013938 putative active site [active] 164757013939 acyl-activating enzyme (AAE) consensus motif; other site 164757013940 putative CoA binding site [chemical binding]; other site 164757013941 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 164757013942 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 164757013943 NAD(P) binding site [chemical binding]; other site 164757013944 catalytic residues [active] 164757013945 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757013946 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757013947 NAD binding site [chemical binding]; other site 164757013948 catalytic Zn binding site [ion binding]; other site 164757013949 substrate binding site [chemical binding]; other site 164757013950 structural Zn binding site [ion binding]; other site 164757013951 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757013952 Cytochrome P450; Region: p450; cl12078 164757013953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 164757013954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757013955 ATP binding site [chemical binding]; other site 164757013956 Mg2+ binding site [ion binding]; other site 164757013957 G-X-G motif; other site 164757013958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757013959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 164757013960 active site 164757013961 phosphorylation site [posttranslational modification] 164757013962 intermolecular recognition site; other site 164757013963 dimerization interface [polypeptide binding]; other site 164757013964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757013965 DNA binding residues [nucleotide binding] 164757013966 dimerization interface [polypeptide binding]; other site 164757013967 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757013968 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 164757013969 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 164757013970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757013971 ATP binding site [chemical binding]; other site 164757013972 putative Mg++ binding site [ion binding]; other site 164757013973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757013974 nucleotide binding region [chemical binding]; other site 164757013975 ATP-binding site [chemical binding]; other site 164757013976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757013977 active site 164757013978 Haemolysin-III related; Region: HlyIII; cl03831 164757013979 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 164757013980 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 164757013981 active site 164757013982 catalytic residues [active] 164757013983 metal binding site [ion binding]; metal-binding site 164757013984 DmpG-like communication domain; Region: DmpG_comm; pfam07836 164757013985 acetaldehyde dehydrogenase; Validated; Region: PRK08300 164757013986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 164757013987 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 164757013988 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 164757013989 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 164757013990 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757013991 enoyl-CoA hydratase; Region: PLN02864 164757013992 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 164757013993 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 164757013994 dimer interaction site [polypeptide binding]; other site 164757013995 substrate-binding tunnel; other site 164757013996 active site 164757013997 catalytic site [active] 164757013998 substrate binding site [chemical binding]; other site 164757013999 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 164757014000 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757014001 DNA binding residues [nucleotide binding] 164757014002 drug binding residues [chemical binding]; other site 164757014003 dimer interface [polypeptide binding]; other site 164757014004 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 164757014005 short chain dehydrogenase; Provisional; Region: PRK06180 164757014006 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 164757014007 NADP binding site [chemical binding]; other site 164757014008 active site 164757014009 steroid binding site; other site 164757014010 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757014011 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 164757014012 Acylphosphatase; Region: Acylphosphatase; pfam00708 164757014013 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 164757014014 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 164757014015 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 164757014016 cyanophycin synthetase; Provisional; Region: PRK14016 164757014017 lipid-transfer protein; Provisional; Region: PRK07855 164757014018 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 164757014019 active site 164757014020 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 164757014021 putative active site [active] 164757014022 putative catalytic site [active] 164757014023 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757014024 active site 164757014025 catalytic site [active] 164757014026 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 164757014027 DUF35 OB-fold domain; Region: DUF35; pfam01796 164757014028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014030 active site 164757014031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014033 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757014034 Cytochrome P450; Region: p450; cl12078 164757014035 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 164757014036 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757014037 dimer interface [polypeptide binding]; other site 164757014038 active site 164757014039 Domain of unknown function (DUF385); Region: DUF385; pfam04075 164757014040 short chain dehydrogenase; Provisional; Region: PRK07791 164757014041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014042 NAD(P) binding site [chemical binding]; other site 164757014043 active site 164757014044 short chain dehydrogenase; Provisional; Region: PRK07856 164757014045 classical (c) SDRs; Region: SDR_c; cd05233 164757014046 NAD(P) binding site [chemical binding]; other site 164757014047 active site 164757014048 enoyl-CoA hydratase; Provisional; Region: PRK06495 164757014049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757014050 substrate binding site [chemical binding]; other site 164757014051 oxyanion hole (OAH) forming residues; other site 164757014052 trimer interface [polypeptide binding]; other site 164757014053 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 164757014054 Coenzyme A transferase; Region: CoA_trans; cl17247 164757014055 Nitronate monooxygenase; Region: NMO; pfam03060 164757014056 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 164757014057 FMN binding site [chemical binding]; other site 164757014058 substrate binding site [chemical binding]; other site 164757014059 putative catalytic residue [active] 164757014060 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 164757014061 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 164757014062 NAD binding site [chemical binding]; other site 164757014063 catalytic Zn binding site [ion binding]; other site 164757014064 substrate binding site [chemical binding]; other site 164757014065 structural Zn binding site [ion binding]; other site 164757014066 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 164757014067 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 164757014068 dimer interface [polypeptide binding]; other site 164757014069 active site 164757014070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757014071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757014072 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 164757014073 short chain dehydrogenase; Provisional; Region: PRK07831 164757014074 classical (c) SDRs; Region: SDR_c; cd05233 164757014075 NAD(P) binding site [chemical binding]; other site 164757014076 active site 164757014077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014079 active site 164757014080 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 164757014081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757014082 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 164757014083 acyl-activating enzyme (AAE) consensus motif; other site 164757014084 putative AMP binding site [chemical binding]; other site 164757014085 putative active site [active] 164757014086 putative CoA binding site [chemical binding]; other site 164757014087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014088 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 164757014089 FAD binding site [chemical binding]; other site 164757014090 substrate binding site [chemical binding]; other site 164757014091 catalytic base [active] 164757014092 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757014093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014095 active site 164757014096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014098 active site 164757014099 aspartate aminotransferase; Provisional; Region: PRK05764 164757014100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757014101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757014102 homodimer interface [polypeptide binding]; other site 164757014103 catalytic residue [active] 164757014104 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757014105 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 164757014106 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757014107 acyl-activating enzyme (AAE) consensus motif; other site 164757014108 AMP binding site [chemical binding]; other site 164757014109 active site 164757014110 CoA binding site [chemical binding]; other site 164757014111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014112 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 164757014113 NAD(P) binding site [chemical binding]; other site 164757014114 active site 164757014115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757014116 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757014117 putative substrate translocation pore; other site 164757014118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757014119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757014120 LysR substrate binding domain; Region: LysR_substrate; pfam03466 164757014121 dimerization interface [polypeptide binding]; other site 164757014122 CsbD-like; Region: CsbD; pfam05532 164757014123 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 164757014124 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 164757014125 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 164757014126 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 164757014127 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 164757014128 active site 164757014129 Fe binding site [ion binding]; other site 164757014130 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 164757014131 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757014132 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757014133 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014134 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 164757014135 Flavin binding site [chemical binding]; other site 164757014136 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 164757014137 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 164757014138 FAD binding pocket [chemical binding]; other site 164757014139 FAD binding motif [chemical binding]; other site 164757014140 phosphate binding motif [ion binding]; other site 164757014141 beta-alpha-beta structure motif; other site 164757014142 NAD(p) ribose binding residues [chemical binding]; other site 164757014143 NAD binding pocket [chemical binding]; other site 164757014144 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 164757014145 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 164757014146 catalytic loop [active] 164757014147 iron binding site [ion binding]; other site 164757014148 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757014149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014150 active site 164757014151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757014152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757014153 active site 164757014154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757014155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757014156 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 164757014157 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 164757014158 Phosphotransferase enzyme family; Region: APH; pfam01636 164757014159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 164757014160 Transcriptional regulators [Transcription]; Region: PurR; COG1609 164757014161 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 164757014162 DNA binding site [nucleotide binding] 164757014163 domain linker motif; other site 164757014164 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 164757014165 putative dimerization interface [polypeptide binding]; other site 164757014166 putative ligand binding site [chemical binding]; other site 164757014167 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 164757014168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 164757014169 ABC-ATPase subunit interface; other site 164757014170 dimer interface [polypeptide binding]; other site 164757014171 putative PBP binding regions; other site 164757014172 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757014173 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 164757014174 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 164757014175 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 164757014176 intersubunit interface [polypeptide binding]; other site 164757014177 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 164757014178 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 164757014179 active site residue [active] 164757014180 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757014181 active site residue [active] 164757014182 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 164757014183 FMN binding site [chemical binding]; other site 164757014184 dimer interface [polypeptide binding]; other site 164757014185 PQQ-like domain; Region: PQQ_2; pfam13360 164757014186 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 164757014187 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 164757014188 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 164757014189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 164757014190 ABC-ATPase subunit interface; other site 164757014191 dimer interface [polypeptide binding]; other site 164757014192 putative PBP binding regions; other site 164757014193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757014194 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 164757014195 Walker A/P-loop; other site 164757014196 ATP binding site [chemical binding]; other site 164757014197 Q-loop/lid; other site 164757014198 ABC transporter signature motif; other site 164757014199 Walker B; other site 164757014200 D-loop; other site 164757014201 H-loop/switch region; other site 164757014202 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 164757014203 putative active site [active] 164757014204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757014205 dimerization interface [polypeptide binding]; other site 164757014206 putative DNA binding site [nucleotide binding]; other site 164757014207 putative Zn2+ binding site [ion binding]; other site 164757014208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757014209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 164757014210 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 164757014211 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 164757014212 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 164757014213 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 164757014214 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 164757014215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757014216 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 164757014217 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 164757014218 active site 164757014219 catalytic site [active] 164757014220 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 164757014221 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 164757014222 transmembrane helices; other site 164757014223 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 164757014224 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 164757014225 active site 164757014226 catalytic triad [active] 164757014227 oxyanion hole [active] 164757014228 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 164757014229 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 164757014230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 164757014231 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 164757014232 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 164757014233 active site 164757014234 HIGH motif; other site 164757014235 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 164757014236 KMSKS motif; other site 164757014237 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 164757014238 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 164757014239 homotrimer interaction site [polypeptide binding]; other site 164757014240 zinc binding site [ion binding]; other site 164757014241 CDP-binding sites; other site 164757014242 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 164757014243 substrate binding site; other site 164757014244 dimer interface; other site 164757014245 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 164757014246 DNA repair protein RadA; Provisional; Region: PRK11823 164757014247 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 164757014248 Walker A motif; other site 164757014249 ATP binding site [chemical binding]; other site 164757014250 Walker B motif; other site 164757014251 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 164757014252 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 164757014253 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 164757014254 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 164757014255 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 164757014256 active site clefts [active] 164757014257 zinc binding site [ion binding]; other site 164757014258 dimer interface [polypeptide binding]; other site 164757014259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 164757014260 endonuclease III; Region: ENDO3c; smart00478 164757014261 minor groove reading motif; other site 164757014262 helix-hairpin-helix signature motif; other site 164757014263 substrate binding pocket [chemical binding]; other site 164757014264 active site 164757014265 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 164757014266 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 164757014267 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757014268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757014269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757014270 metal binding site [ion binding]; metal-binding site 164757014271 active site 164757014272 I-site; other site 164757014273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 164757014274 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 164757014275 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 164757014276 conserved cys residue [active] 164757014277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757014278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757014279 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757014280 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 164757014281 catalytic site [active] 164757014282 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 164757014283 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 164757014284 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 164757014285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757014286 catalytic core [active] 164757014287 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 164757014288 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 164757014289 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 164757014290 Clp amino terminal domain; Region: Clp_N; pfam02861 164757014291 Clp amino terminal domain; Region: Clp_N; pfam02861 164757014292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757014293 Walker A motif; other site 164757014294 ATP binding site [chemical binding]; other site 164757014295 Walker B motif; other site 164757014296 arginine finger; other site 164757014297 UvrB/uvrC motif; Region: UVR; pfam02151 164757014298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757014299 Walker A motif; other site 164757014300 ATP binding site [chemical binding]; other site 164757014301 Walker B motif; other site 164757014302 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 164757014303 Lsr2; Region: Lsr2; pfam11774 164757014304 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 164757014305 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 164757014306 dimer interface [polypeptide binding]; other site 164757014307 putative anticodon binding site; other site 164757014308 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 164757014309 motif 1; other site 164757014310 dimer interface [polypeptide binding]; other site 164757014311 active site 164757014312 motif 2; other site 164757014313 motif 3; other site 164757014314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 164757014315 dimer interface [polypeptide binding]; other site 164757014316 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 164757014317 active site 164757014318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 164757014319 substrate binding site [chemical binding]; other site 164757014320 catalytic residue [active] 164757014321 pantothenate kinase; Reviewed; Region: PRK13318 164757014322 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 164757014323 tetramerization interface [polypeptide binding]; other site 164757014324 active site 164757014325 Pantoate-beta-alanine ligase; Region: PanC; cd00560 164757014326 pantoate--beta-alanine ligase; Region: panC; TIGR00018 164757014327 active site 164757014328 ATP-binding site [chemical binding]; other site 164757014329 pantoate-binding site; other site 164757014330 HXXH motif; other site 164757014331 Rossmann-like domain; Region: Rossmann-like; pfam10727 164757014332 Uncharacterized conserved protein [Function unknown]; Region: COG5495 164757014333 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 164757014334 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 164757014335 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 164757014336 catalytic center binding site [active] 164757014337 ATP binding site [chemical binding]; other site 164757014338 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 164757014339 homooctamer interface [polypeptide binding]; other site 164757014340 active site 164757014341 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 164757014342 dihydropteroate synthase; Region: DHPS; TIGR01496 164757014343 substrate binding pocket [chemical binding]; other site 164757014344 dimer interface [polypeptide binding]; other site 164757014345 inhibitor binding site; inhibition site 164757014346 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 164757014347 homodecamer interface [polypeptide binding]; other site 164757014348 GTP cyclohydrolase I; Provisional; Region: PLN03044 164757014349 active site 164757014350 putative catalytic site residues [active] 164757014351 zinc binding site [ion binding]; other site 164757014352 GTP-CH-I/GFRP interaction surface; other site 164757014353 FtsH Extracellular; Region: FtsH_ext; pfam06480 164757014354 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 164757014355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757014356 Walker A motif; other site 164757014357 ATP binding site [chemical binding]; other site 164757014358 Walker B motif; other site 164757014359 arginine finger; other site 164757014360 Peptidase family M41; Region: Peptidase_M41; pfam01434 164757014361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757014362 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 164757014363 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757014364 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 164757014365 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757014366 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 164757014367 putative NAD(P) binding site [chemical binding]; other site 164757014368 catalytic Zn binding site [ion binding]; other site 164757014369 Uncharacterized conserved protein [Function unknown]; Region: COG2968 164757014370 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 164757014371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757014372 active site 164757014373 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 164757014374 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 164757014375 Ligand Binding Site [chemical binding]; other site 164757014376 TilS substrate binding domain; Region: TilS; pfam09179 164757014377 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 164757014378 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 164757014379 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 164757014380 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 164757014381 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 164757014382 dimer interface [polypeptide binding]; other site 164757014383 substrate binding site [chemical binding]; other site 164757014384 metal binding sites [ion binding]; metal-binding site 164757014385 putative OHCU decarboxylase; Provisional; Region: PRK13798 164757014386 allantoicase; Provisional; Region: PRK13257 164757014387 Allantoicase repeat; Region: Allantoicase; pfam03561 164757014388 Allantoicase repeat; Region: Allantoicase; pfam03561 164757014389 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 164757014390 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 164757014391 putative active site [active] 164757014392 putative metal binding site [ion binding]; other site 164757014393 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 164757014394 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 164757014395 dimer interface [polypeptide binding]; other site 164757014396 NADP binding site [chemical binding]; other site 164757014397 catalytic residues [active] 164757014398 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 164757014399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 164757014400 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 164757014401 acyl-activating enzyme (AAE) consensus motif; other site 164757014402 AMP binding site [chemical binding]; other site 164757014403 active site 164757014404 CoA binding site [chemical binding]; other site 164757014405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 164757014406 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 164757014407 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 164757014408 putative trimer interface [polypeptide binding]; other site 164757014409 putative CoA binding site [chemical binding]; other site 164757014410 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 164757014411 putative trimer interface [polypeptide binding]; other site 164757014412 putative CoA binding site [chemical binding]; other site 164757014413 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 164757014414 Zn binding site [ion binding]; other site 164757014415 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 164757014416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014417 NAD(P) binding site [chemical binding]; other site 164757014418 active site 164757014419 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 164757014420 DNA polymerase III subunit delta'; Validated; Region: PRK07940 164757014421 DNA polymerase III subunit delta'; Validated; Region: PRK08485 164757014422 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 164757014423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 164757014424 dimerization interface [polypeptide binding]; other site 164757014425 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 164757014426 cyclase homology domain; Region: CHD; cd07302 164757014427 nucleotidyl binding site; other site 164757014428 metal binding site [ion binding]; metal-binding site 164757014429 dimer interface [polypeptide binding]; other site 164757014430 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 164757014431 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 164757014432 active site 164757014433 interdomain interaction site; other site 164757014434 putative metal-binding site [ion binding]; other site 164757014435 nucleotide binding site [chemical binding]; other site 164757014436 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 164757014437 domain I; other site 164757014438 phosphate binding site [ion binding]; other site 164757014439 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 164757014440 domain II; other site 164757014441 domain III; other site 164757014442 nucleotide binding site [chemical binding]; other site 164757014443 DNA binding groove [nucleotide binding] 164757014444 catalytic site [active] 164757014445 domain IV; other site 164757014446 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 164757014447 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 164757014448 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 164757014449 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 164757014450 DNA-binding site [nucleotide binding]; DNA binding site 164757014451 RNA-binding motif; other site 164757014452 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 164757014453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757014454 ATP binding site [chemical binding]; other site 164757014455 putative Mg++ binding site [ion binding]; other site 164757014456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757014457 nucleotide binding region [chemical binding]; other site 164757014458 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 164757014459 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 164757014460 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 164757014461 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 164757014462 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 164757014463 ATP binding site [chemical binding]; other site 164757014464 Walker A motif; other site 164757014465 hexamer interface [polypeptide binding]; other site 164757014466 Walker B motif; other site 164757014467 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 164757014468 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 164757014469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757014470 motif II; other site 164757014471 acetyl-CoA synthetase; Provisional; Region: PRK00174 164757014472 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 164757014473 active site 164757014474 CoA binding site [chemical binding]; other site 164757014475 acyl-activating enzyme (AAE) consensus motif; other site 164757014476 AMP binding site [chemical binding]; other site 164757014477 acetate binding site [chemical binding]; other site 164757014478 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 164757014479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757014480 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 164757014481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757014482 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 164757014483 putative active site [active] 164757014484 putative CoA binding site [chemical binding]; other site 164757014485 nudix motif; other site 164757014486 metal binding site [ion binding]; metal-binding site 164757014487 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 164757014488 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757014489 catalytic residues [active] 164757014490 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 164757014491 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 164757014492 minor groove reading motif; other site 164757014493 helix-hairpin-helix signature motif; other site 164757014494 substrate binding pocket [chemical binding]; other site 164757014495 active site 164757014496 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 164757014497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 164757014498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 164757014499 ligand binding site [chemical binding]; other site 164757014500 flexible hinge region; other site 164757014501 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 164757014502 putative switch regulator; other site 164757014503 non-specific DNA interactions [nucleotide binding]; other site 164757014504 DNA binding site [nucleotide binding] 164757014505 sequence specific DNA binding site [nucleotide binding]; other site 164757014506 putative cAMP binding site [chemical binding]; other site 164757014507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757014508 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 164757014509 homotrimer interaction site [polypeptide binding]; other site 164757014510 putative active site [active] 164757014511 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 164757014512 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 164757014513 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 164757014514 P loop; other site 164757014515 Nucleotide binding site [chemical binding]; other site 164757014516 DTAP/Switch II; other site 164757014517 Switch I; other site 164757014518 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 164757014519 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 164757014520 DTAP/Switch II; other site 164757014521 Switch I; other site 164757014522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757014523 Transcription factor WhiB; Region: Whib; pfam02467 164757014524 Transglycosylase; Region: Transgly; pfam00912 164757014525 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 164757014526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 164757014527 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 164757014528 phosphodiesterase YaeI; Provisional; Region: PRK11340 164757014529 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 164757014530 putative active site [active] 164757014531 putative metal binding site [ion binding]; other site 164757014532 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 164757014533 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 164757014534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757014535 catalytic residue [active] 164757014536 Cytochrome P450; Region: p450; cl12078 164757014537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757014538 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 164757014539 active site 164757014540 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 164757014541 catalytic triad [active] 164757014542 dimer interface [polypeptide binding]; other site 164757014543 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 164757014544 putative methyltransferase; Provisional; Region: PRK14967 164757014545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757014546 S-adenosylmethionine binding site [chemical binding]; other site 164757014547 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757014548 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 164757014549 Yqey-like protein; Region: YqeY; pfam09424 164757014550 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 164757014551 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 164757014552 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757014553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757014554 Walker A motif; other site 164757014555 ATP binding site [chemical binding]; other site 164757014556 Walker B motif; other site 164757014557 arginine finger; other site 164757014558 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 164757014559 Protein of unknown function DUF58; Region: DUF58; pfam01882 164757014560 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 164757014561 Predicted membrane protein/domain [Function unknown]; Region: COG1714 164757014562 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 164757014563 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 164757014564 putative active site [active] 164757014565 putative FMN binding site [chemical binding]; other site 164757014566 putative substrate binding site [chemical binding]; other site 164757014567 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 164757014568 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 164757014569 dimer interface [polypeptide binding]; other site 164757014570 PYR/PP interface [polypeptide binding]; other site 164757014571 TPP binding site [chemical binding]; other site 164757014572 substrate binding site [chemical binding]; other site 164757014573 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 164757014574 Domain of unknown function; Region: EKR; pfam10371 164757014575 4Fe-4S binding domain; Region: Fer4_6; pfam12837 164757014576 4Fe-4S binding domain; Region: Fer4; pfam00037 164757014577 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 164757014578 TPP-binding site [chemical binding]; other site 164757014579 dimer interface [polypeptide binding]; other site 164757014580 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 164757014581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757014582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757014583 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 164757014584 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 164757014585 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 164757014586 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757014587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757014588 DNA-binding site [nucleotide binding]; DNA binding site 164757014589 FCD domain; Region: FCD; pfam07729 164757014590 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 164757014591 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 164757014592 Na binding site [ion binding]; other site 164757014593 putative substrate binding site [chemical binding]; other site 164757014594 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757014595 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 164757014596 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757014597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757014598 dimerization interface [polypeptide binding]; other site 164757014599 putative DNA binding site [nucleotide binding]; other site 164757014600 putative Zn2+ binding site [ion binding]; other site 164757014601 glycerol kinase; Provisional; Region: glpK; PRK00047 164757014602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 164757014603 nucleotide binding site [chemical binding]; other site 164757014604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757014605 S-adenosylmethionine binding site [chemical binding]; other site 164757014606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757014607 metabolite-proton symporter; Region: 2A0106; TIGR00883 164757014608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757014609 S-adenosylmethionine binding site [chemical binding]; other site 164757014610 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 164757014611 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 164757014612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757014613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757014614 catalytic residue [active] 164757014615 catalytic residue [active] 164757014616 Uncharacterized conserved protein [Function unknown]; Region: COG4301 164757014617 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 164757014618 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 164757014619 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 164757014620 putative active site [active] 164757014621 putative dimer interface [polypeptide binding]; other site 164757014622 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 164757014623 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 164757014624 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 164757014625 PknH-like extracellular domain; Region: PknH_C; pfam14032 164757014626 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 164757014627 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 164757014628 metal binding site 2 [ion binding]; metal-binding site 164757014629 putative DNA binding helix; other site 164757014630 metal binding site 1 [ion binding]; metal-binding site 164757014631 structural Zn2+ binding site [ion binding]; other site 164757014632 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 164757014633 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 164757014634 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 164757014635 aspartate kinase; Reviewed; Region: PRK06635 164757014636 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 164757014637 putative nucleotide binding site [chemical binding]; other site 164757014638 putative catalytic residues [active] 164757014639 putative Mg ion binding site [ion binding]; other site 164757014640 putative aspartate binding site [chemical binding]; other site 164757014641 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 164757014642 putative allosteric regulatory site; other site 164757014643 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 164757014644 putative allosteric regulatory residue; other site 164757014645 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 164757014646 putative FMN binding site [chemical binding]; other site 164757014647 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 164757014648 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 164757014649 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 164757014650 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757014651 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 164757014652 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 164757014653 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 164757014654 active site 164757014655 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 164757014656 domain_subunit interface; other site 164757014657 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 164757014658 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 164757014659 active site 164757014660 FMN binding site [chemical binding]; other site 164757014661 substrate binding site [chemical binding]; other site 164757014662 3Fe-4S cluster binding site [ion binding]; other site 164757014663 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757014664 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 164757014665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 164757014666 non-specific DNA binding site [nucleotide binding]; other site 164757014667 salt bridge; other site 164757014668 sequence-specific DNA binding site [nucleotide binding]; other site 164757014669 Cupin domain; Region: Cupin_2; pfam07883 164757014670 2-isopropylmalate synthase; Validated; Region: PRK03739 164757014671 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 164757014672 active site 164757014673 catalytic residues [active] 164757014674 metal binding site [ion binding]; metal-binding site 164757014675 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 164757014676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 164757014677 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 164757014678 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 164757014679 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 164757014680 active site 164757014681 catalytic site [active] 164757014682 substrate binding site [chemical binding]; other site 164757014683 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 164757014684 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 164757014685 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 164757014686 catalytic triad [active] 164757014687 recombination protein RecR; Reviewed; Region: recR; PRK00076 164757014688 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 164757014689 RecR protein; Region: RecR; pfam02132 164757014690 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 164757014691 putative active site [active] 164757014692 putative metal-binding site [ion binding]; other site 164757014693 tetramer interface [polypeptide binding]; other site 164757014694 hypothetical protein; Validated; Region: PRK00153 164757014695 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 164757014696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 164757014697 active site 164757014698 metal binding site [ion binding]; metal-binding site 164757014699 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 164757014700 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 164757014701 FAD binding domain; Region: FAD_binding_4; pfam01565 164757014702 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 164757014703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757014704 S-adenosylmethionine binding site [chemical binding]; other site 164757014705 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 164757014706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757014707 Walker A motif; other site 164757014708 ATP binding site [chemical binding]; other site 164757014709 Walker B motif; other site 164757014710 arginine finger; other site 164757014711 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 164757014712 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 164757014713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757014714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757014715 catalytic residue [active] 164757014716 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 164757014717 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 164757014718 protein binding site [polypeptide binding]; other site 164757014719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757014720 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 164757014721 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 164757014722 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 164757014723 nucleotide binding site [chemical binding]; other site 164757014724 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 164757014725 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 164757014726 DNA binding site [nucleotide binding] 164757014727 active site 164757014728 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 164757014729 DNA binding site [nucleotide binding] 164757014730 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 164757014731 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757014732 active site 164757014733 DNA binding site [nucleotide binding] 164757014734 Int/Topo IB signature motif; other site 164757014735 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 164757014736 active site 164757014737 catalytic residues [active] 164757014738 Int/Topo IB signature motif; other site 164757014739 DNA binding site [nucleotide binding] 164757014740 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757014741 active site 164757014742 DNA binding site [nucleotide binding] 164757014743 Int/Topo IB signature motif; other site 164757014744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 164757014745 active site 164757014746 DNA binding site [nucleotide binding] 164757014747 Int/Topo IB signature motif; other site 164757014748 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 164757014749 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 164757014750 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 164757014751 active site 164757014752 DNA binding site [nucleotide binding] 164757014753 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 164757014754 DNA binding site [nucleotide binding] 164757014755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757014756 dimerization interface [polypeptide binding]; other site 164757014757 putative DNA binding site [nucleotide binding]; other site 164757014758 putative Zn2+ binding site [ion binding]; other site 164757014759 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 164757014760 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757014761 Soluble P-type ATPase [General function prediction only]; Region: COG4087 164757014762 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 164757014763 Short C-terminal domain; Region: SHOCT; pfam09851 164757014764 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 164757014765 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757014766 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757014767 active site 164757014768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757014769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757014770 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757014771 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757014772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014773 NAD(P) binding site [chemical binding]; other site 164757014774 active site 164757014775 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 164757014776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757014777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757014778 DNA binding residues [nucleotide binding] 164757014779 AAA ATPase domain; Region: AAA_16; pfam13191 164757014780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 164757014781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 164757014782 DNA binding residues [nucleotide binding] 164757014783 dimerization interface [polypeptide binding]; other site 164757014784 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 164757014785 putative FMN binding site [chemical binding]; other site 164757014786 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 164757014787 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757014788 classical (c) SDRs; Region: SDR_c; cd05233 164757014789 NAD(P) binding site [chemical binding]; other site 164757014790 active site 164757014791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757014792 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757014793 Cytochrome P450; Region: p450; cl12078 164757014794 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 164757014795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757014796 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757014797 active site 164757014798 metal binding site [ion binding]; metal-binding site 164757014799 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 164757014800 classical (c) SDRs; Region: SDR_c; cd05233 164757014801 NAD(P) binding site [chemical binding]; other site 164757014802 active site 164757014803 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 164757014804 FMN binding site [chemical binding]; other site 164757014805 dimer interface [polypeptide binding]; other site 164757014806 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 164757014807 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757014808 short chain dehydrogenase; Provisional; Region: PRK08303 164757014809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014810 NAD(P) binding site [chemical binding]; other site 164757014811 active site 164757014812 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757014813 Cytochrome P450; Region: p450; cl12078 164757014814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757014815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757014816 NAD(P) binding site [chemical binding]; other site 164757014817 active site 164757014818 choline dehydrogenase; Validated; Region: PRK02106 164757014819 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 164757014820 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 164757014821 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 164757014822 active site 164757014823 DNA binding site [nucleotide binding] 164757014824 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 164757014825 DNA binding site [nucleotide binding] 164757014826 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 164757014827 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 164757014828 homodimer interface [polypeptide binding]; other site 164757014829 putative substrate binding pocket [chemical binding]; other site 164757014830 diiron center [ion binding]; other site 164757014831 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 164757014832 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 164757014833 active site 164757014834 HIGH motif; other site 164757014835 nucleotide binding site [chemical binding]; other site 164757014836 active site 164757014837 KMSKS motif; other site 164757014838 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757014839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757014840 substrate binding pocket [chemical binding]; other site 164757014841 membrane-bound complex binding site; other site 164757014842 hinge residues; other site 164757014843 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 164757014844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757014845 dimer interface [polypeptide binding]; other site 164757014846 conserved gate region; other site 164757014847 putative PBP binding loops; other site 164757014848 ABC-ATPase subunit interface; other site 164757014849 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 164757014850 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757014851 Walker A/P-loop; other site 164757014852 ATP binding site [chemical binding]; other site 164757014853 Q-loop/lid; other site 164757014854 ABC transporter signature motif; other site 164757014855 Walker B; other site 164757014856 D-loop; other site 164757014857 H-loop/switch region; other site 164757014858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757014859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757014860 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 164757014861 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 164757014862 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757014863 Cytochrome P450; Region: p450; cl12078 164757014864 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 164757014865 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 164757014866 haloalkane dehalogenase; Provisional; Region: PRK00870 164757014867 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 164757014868 PE-PPE domain; Region: PE-PPE; pfam08237 164757014869 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 164757014870 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 164757014871 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 164757014872 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 164757014873 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 164757014874 alpha-beta subunit interface [polypeptide binding]; other site 164757014875 alpha-gamma subunit interface [polypeptide binding]; other site 164757014876 active site 164757014877 substrate and K+ binding site; other site 164757014878 K+ binding site [ion binding]; other site 164757014879 cobalamin binding site [chemical binding]; other site 164757014880 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 164757014881 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 164757014882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 164757014883 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 164757014884 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 164757014885 active site 164757014886 Zn binding site [ion binding]; other site 164757014887 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 164757014888 prephenate dehydrogenase; Validated; Region: PRK06545 164757014889 prephenate dehydrogenase; Validated; Region: PRK08507 164757014890 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 164757014891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757014892 dimer interface [polypeptide binding]; other site 164757014893 ABC-ATPase subunit interface; other site 164757014894 putative PBP binding loops; other site 164757014895 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 164757014896 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757014897 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 164757014898 Walker A/P-loop; other site 164757014899 ATP binding site [chemical binding]; other site 164757014900 Q-loop/lid; other site 164757014901 ABC transporter signature motif; other site 164757014902 Walker B; other site 164757014903 D-loop; other site 164757014904 H-loop/switch region; other site 164757014905 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 164757014906 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 164757014907 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 164757014908 putative active site [active] 164757014909 putative substrate binding site [chemical binding]; other site 164757014910 ATP binding site [chemical binding]; other site 164757014911 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757014912 catalytic core [active] 164757014913 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 164757014914 classical (c) SDRs; Region: SDR_c; cd05233 164757014915 NAD(P) binding site [chemical binding]; other site 164757014916 active site 164757014917 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 164757014918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 164757014919 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 164757014920 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 164757014921 Predicted transcriptional regulators [Transcription]; Region: COG1733 164757014922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757014923 dimerization interface [polypeptide binding]; other site 164757014924 putative Zn2+ binding site [ion binding]; other site 164757014925 putative DNA binding site [nucleotide binding]; other site 164757014926 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 164757014927 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 164757014928 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 164757014929 Protein of unknown function (DUF419); Region: DUF419; cl15265 164757014930 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 164757014931 active site 164757014932 metal binding site [ion binding]; metal-binding site 164757014933 homotetramer interface [polypeptide binding]; other site 164757014934 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 164757014935 Cutinase; Region: Cutinase; pfam01083 164757014936 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757014937 Ligand Binding Site [chemical binding]; other site 164757014938 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 164757014939 Ligand Binding Site [chemical binding]; other site 164757014940 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 164757014941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757014942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757014943 homodimer interface [polypeptide binding]; other site 164757014944 catalytic residue [active] 164757014945 GXWXG protein; Region: GXWXG; pfam14231 164757014946 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 164757014947 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 164757014948 TIGR03086 family protein; Region: TIGR03086 164757014949 enoyl-CoA hydratase; Provisional; Region: PRK06142 164757014950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 164757014951 substrate binding site [chemical binding]; other site 164757014952 oxyanion hole (OAH) forming residues; other site 164757014953 trimer interface [polypeptide binding]; other site 164757014954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757014955 MarR family; Region: MarR; pfam01047 164757014956 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 164757014957 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 164757014958 NAD(P) binding site [chemical binding]; other site 164757014959 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 164757014960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757014961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757014962 catalytic residue [active] 164757014963 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 164757014964 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 164757014965 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 164757014966 Walker A/P-loop; other site 164757014967 ATP binding site [chemical binding]; other site 164757014968 Q-loop/lid; other site 164757014969 ABC transporter signature motif; other site 164757014970 Walker B; other site 164757014971 D-loop; other site 164757014972 H-loop/switch region; other site 164757014973 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 164757014974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757014975 active site 164757014976 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 164757014977 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 164757014978 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 164757014979 Phosphotransferase enzyme family; Region: APH; pfam01636 164757014980 Uncharacterized conserved protein [Function unknown]; Region: COG2128 164757014981 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 164757014982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757014983 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 164757014984 DNA-binding site [nucleotide binding]; DNA binding site 164757014985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 164757014986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757014987 homodimer interface [polypeptide binding]; other site 164757014988 catalytic residue [active] 164757014989 Predicted membrane protein [Function unknown]; Region: COG2246 164757014990 GtrA-like protein; Region: GtrA; pfam04138 164757014991 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 164757014992 FAD binding domain; Region: FAD_binding_4; pfam01565 164757014993 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 164757014994 short chain dehydrogenase; Provisional; Region: PRK07904 164757014995 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 164757014996 NAD(P) binding site [chemical binding]; other site 164757014997 active site 164757014998 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 164757014999 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 164757015000 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 164757015001 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 164757015002 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 164757015003 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757015004 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757015005 active site 164757015006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757015007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757015008 active site 164757015009 ATP binding site [chemical binding]; other site 164757015010 substrate binding site [chemical binding]; other site 164757015011 activation loop (A-loop); other site 164757015012 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 164757015013 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 164757015014 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 164757015015 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 164757015016 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757015017 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 164757015018 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 164757015019 active site 164757015020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 164757015021 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 164757015022 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 164757015023 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 164757015024 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 164757015025 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757015026 acyl-activating enzyme (AAE) consensus motif; other site 164757015027 active site 164757015028 Cutinase; Region: Cutinase; pfam01083 164757015029 Putative esterase; Region: Esterase; pfam00756 164757015030 Putative esterase; Region: Esterase; pfam00756 164757015031 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 164757015032 UbiA prenyltransferase family; Region: UbiA; pfam01040 164757015033 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 164757015034 active site 164757015035 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 164757015036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 164757015037 active site 164757015038 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 164757015039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757015040 UDP-galactopyranose mutase; Region: GLF; pfam03275 164757015041 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 164757015042 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 164757015043 amidase catalytic site [active] 164757015044 Zn binding residues [ion binding]; other site 164757015045 substrate binding site [chemical binding]; other site 164757015046 LGFP repeat; Region: LGFP; pfam08310 164757015047 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 164757015048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757015049 active site 164757015050 motif I; other site 164757015051 motif II; other site 164757015052 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 164757015053 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757015054 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 164757015055 putative acyl-acceptor binding pocket; other site 164757015056 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757015057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 164757015058 putative acyl-acceptor binding pocket; other site 164757015059 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 164757015060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757015061 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757015062 iron-sulfur cluster [ion binding]; other site 164757015063 [2Fe-2S] cluster binding site [ion binding]; other site 164757015064 seryl-tRNA synthetase; Provisional; Region: PRK05431 164757015065 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 164757015066 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 164757015067 dimer interface [polypeptide binding]; other site 164757015068 active site 164757015069 motif 1; other site 164757015070 motif 2; other site 164757015071 motif 3; other site 164757015072 Septum formation; Region: Septum_form; pfam13845 164757015073 Septum formation; Region: Septum_form; pfam13845 164757015074 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 164757015075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757015076 catalytic core [active] 164757015077 prephenate dehydratase; Provisional; Region: PRK11898 164757015078 Prephenate dehydratase; Region: PDT; pfam00800 164757015079 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 164757015080 putative L-Phe binding site [chemical binding]; other site 164757015081 CAAX protease self-immunity; Region: Abi; pfam02517 164757015082 Transcriptional regulator [Transcription]; Region: LytR; COG1316 164757015083 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 164757015084 Ferritin-like domain; Region: Ferritin; pfam00210 164757015085 ferroxidase diiron center [ion binding]; other site 164757015086 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 164757015087 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 164757015088 putative active site [active] 164757015089 catalytic site [active] 164757015090 putative metal binding site [ion binding]; other site 164757015091 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 164757015092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757015093 active site residue [active] 164757015094 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 164757015095 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 164757015096 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 164757015097 Predicted membrane protein [Function unknown]; Region: COG2119 164757015098 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 164757015099 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 164757015100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 164757015101 CopC domain; Region: CopC; pfam04234 164757015102 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 164757015103 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 164757015104 DNA binding residues [nucleotide binding] 164757015105 dimer interface [polypeptide binding]; other site 164757015106 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 164757015107 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 164757015108 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757015109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757015110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015112 DNA polymerase IV; Validated; Region: PRK03858 164757015113 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 164757015114 active site 164757015115 DNA binding site [nucleotide binding] 164757015116 hydroperoxidase II; Provisional; Region: katE; PRK11249 164757015117 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 164757015118 heme binding pocket [chemical binding]; other site 164757015119 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 164757015120 domain interactions; other site 164757015121 hypothetical protein; Provisional; Region: PRK07945 164757015122 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 164757015123 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 164757015124 active site 164757015125 TIGR03086 family protein; Region: TIGR03086 164757015126 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 164757015127 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757015128 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 164757015129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757015130 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 164757015131 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 164757015132 active site 164757015133 dimer interface [polypeptide binding]; other site 164757015134 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 164757015135 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 164757015136 active site 164757015137 FMN binding site [chemical binding]; other site 164757015138 substrate binding site [chemical binding]; other site 164757015139 3Fe-4S cluster binding site [ion binding]; other site 164757015140 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 164757015141 domain interface; other site 164757015142 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 164757015143 CoenzymeA binding site [chemical binding]; other site 164757015144 subunit interaction site [polypeptide binding]; other site 164757015145 PHB binding site; other site 164757015146 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 164757015147 amphipathic channel; other site 164757015148 Asn-Pro-Ala signature motifs; other site 164757015149 Protein of unknown function (DUF732); Region: DUF732; pfam05305 164757015150 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 164757015151 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 164757015152 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 164757015153 dimerization interface [polypeptide binding]; other site 164757015154 DPS ferroxidase diiron center [ion binding]; other site 164757015155 ion pore; other site 164757015156 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 164757015157 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 164757015158 minor groove reading motif; other site 164757015159 helix-hairpin-helix signature motif; other site 164757015160 active site 164757015161 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 164757015162 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 164757015163 substrate binding pocket [chemical binding]; other site 164757015164 chain length determination region; other site 164757015165 substrate-Mg2+ binding site; other site 164757015166 catalytic residues [active] 164757015167 aspartate-rich region 1; other site 164757015168 active site lid residues [active] 164757015169 aspartate-rich region 2; other site 164757015170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757015171 phytoene desaturase; Region: crtI_fam; TIGR02734 164757015172 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 164757015173 active site lid residues [active] 164757015174 substrate binding pocket [chemical binding]; other site 164757015175 catalytic residues [active] 164757015176 substrate-Mg2+ binding site; other site 164757015177 aspartate-rich region 1; other site 164757015178 aspartate-rich region 2; other site 164757015179 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 164757015180 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 164757015181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 164757015182 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 164757015183 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 164757015184 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 164757015185 iron-sulfur cluster [ion binding]; other site 164757015186 [2Fe-2S] cluster binding site [ion binding]; other site 164757015187 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 164757015188 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 164757015189 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 164757015190 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 164757015191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 164757015192 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 164757015193 hydrophobic ligand binding site; other site 164757015194 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 164757015195 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757015196 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 164757015197 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757015198 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 164757015199 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 164757015200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757015201 NAD(P) binding site [chemical binding]; other site 164757015202 active site 164757015203 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757015204 SelR domain; Region: SelR; pfam01641 164757015205 methionine sulfoxide reductase B; Provisional; Region: PRK00222 164757015206 methionine sulfoxide reductase A; Provisional; Region: PRK14054 164757015207 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757015208 Cytochrome P450; Region: p450; cl12078 164757015209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015211 Methyltransferase domain; Region: Methyltransf_24; pfam13578 164757015212 FOG: CBS domain [General function prediction only]; Region: COG0517 164757015213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 164757015214 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 164757015215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757015216 dimerization interface [polypeptide binding]; other site 164757015217 putative Zn2+ binding site [ion binding]; other site 164757015218 putative DNA binding site [nucleotide binding]; other site 164757015219 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 164757015220 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 164757015221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 164757015222 S-adenosylmethionine binding site [chemical binding]; other site 164757015223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 164757015224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 164757015225 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 164757015226 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757015227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015228 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757015229 active site 164757015230 Domain of unknown function (DUF427); Region: DUF427; cl00998 164757015231 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 164757015232 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 164757015233 NAD binding site [chemical binding]; other site 164757015234 catalytic Zn binding site [ion binding]; other site 164757015235 structural Zn binding site [ion binding]; other site 164757015236 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757015237 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 164757015238 Isochorismatase family; Region: Isochorismatase; pfam00857 164757015239 catalytic triad [active] 164757015240 metal binding site [ion binding]; metal-binding site 164757015241 conserved cis-peptide bond; other site 164757015242 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 164757015243 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 164757015244 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 164757015245 active site 164757015246 catalytic site [active] 164757015247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015249 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 164757015250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757015251 active site 164757015252 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 164757015253 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757015254 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757015255 active site 164757015256 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 164757015257 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 164757015258 trehalose synthase; Region: treS_nterm; TIGR02456 164757015259 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 164757015260 active site 164757015261 catalytic site [active] 164757015262 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757015263 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 164757015264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757015265 active site 164757015266 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 164757015267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 164757015268 Walker A/P-loop; other site 164757015269 ATP binding site [chemical binding]; other site 164757015270 Q-loop/lid; other site 164757015271 ABC transporter signature motif; other site 164757015272 Walker B; other site 164757015273 D-loop; other site 164757015274 H-loop/switch region; other site 164757015275 TOBE domain; Region: TOBE_2; pfam08402 164757015276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757015277 dimer interface [polypeptide binding]; other site 164757015278 conserved gate region; other site 164757015279 putative PBP binding loops; other site 164757015280 ABC-ATPase subunit interface; other site 164757015281 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 164757015282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 164757015283 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 164757015284 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 164757015285 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 164757015286 Cupin domain; Region: Cupin_2; cl17218 164757015287 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 164757015288 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757015289 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 164757015290 putative hydrophobic ligand binding site [chemical binding]; other site 164757015291 protein interface [polypeptide binding]; other site 164757015292 gate; other site 164757015293 dihydroxyacetone kinase; Provisional; Region: PRK14479 164757015294 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 164757015295 DAK2 domain; Region: Dak2; pfam02734 164757015296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015298 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 164757015299 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 164757015300 elongation factor G; Reviewed; Region: PRK12740 164757015301 G1 box; other site 164757015302 putative GEF interaction site [polypeptide binding]; other site 164757015303 GTP/Mg2+ binding site [chemical binding]; other site 164757015304 Switch I region; other site 164757015305 G2 box; other site 164757015306 G3 box; other site 164757015307 Switch II region; other site 164757015308 G4 box; other site 164757015309 G5 box; other site 164757015310 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 164757015311 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 164757015312 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 164757015313 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 164757015314 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 164757015315 mce related protein; Region: MCE; pfam02470 164757015316 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 164757015317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 164757015318 catalytic core [active] 164757015319 MMPL family; Region: MMPL; pfam03176 164757015320 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757015321 Rhomboid family; Region: Rhomboid; pfam01694 164757015322 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757015323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757015324 active site 164757015325 amidase; Validated; Region: PRK06565 164757015326 Amidase; Region: Amidase; cl11426 164757015327 Cupin; Region: Cupin_6; pfam12852 164757015328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 164757015329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 164757015330 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 164757015331 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 164757015332 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 164757015333 Cytochrome P450; Region: p450; cl12078 164757015334 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757015335 anti sigma factor interaction site; other site 164757015336 regulatory phosphorylation site [posttranslational modification]; other site 164757015337 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 164757015338 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 164757015339 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757015340 anti sigma factor interaction site; other site 164757015341 regulatory phosphorylation site [posttranslational modification]; other site 164757015342 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 164757015343 B12 binding domain; Region: B12-binding_2; pfam02607 164757015344 B12 binding domain; Region: B12-binding; pfam02310 164757015345 B12 binding site [chemical binding]; other site 164757015346 von Willebrand factor type A domain; Region: VWA_2; pfam13519 164757015347 Protein of unknown function DUF58; Region: DUF58; pfam01882 164757015348 MoxR-like ATPases [General function prediction only]; Region: COG0714 164757015349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 164757015350 Walker A motif; other site 164757015351 ATP binding site [chemical binding]; other site 164757015352 Walker B motif; other site 164757015353 arginine finger; other site 164757015354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757015357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015359 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 164757015360 putative hydrophobic ligand binding site [chemical binding]; other site 164757015361 short chain dehydrogenase; Provisional; Region: PRK06197 164757015362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757015363 NAD(P) binding site [chemical binding]; other site 164757015364 active site 164757015365 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 164757015366 active site 164757015367 catalytic triad [active] 164757015368 oxyanion hole [active] 164757015369 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 164757015370 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 164757015371 amino acid transporter; Region: 2A0306; TIGR00909 164757015372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757015373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757015374 active site 164757015375 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757015376 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757015377 PAS fold; Region: PAS_3; pfam08447 164757015378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 164757015379 putative active site [active] 164757015380 heme pocket [chemical binding]; other site 164757015381 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757015382 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 164757015383 anti sigma factor interaction site; other site 164757015384 regulatory phosphorylation site [posttranslational modification]; other site 164757015385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757015386 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 164757015387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757015389 active site 164757015390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015391 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757015392 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757015393 active site 164757015394 hypothetical protein; Validated; Region: PRK07198 164757015395 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 164757015396 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 164757015397 dimerization interface [polypeptide binding]; other site 164757015398 active site 164757015399 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 164757015400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 164757015401 active site 164757015402 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 164757015403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757015404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757015405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757015406 active site 164757015407 metal binding site [ion binding]; metal-binding site 164757015408 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 164757015409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757015410 ATP binding site [chemical binding]; other site 164757015411 putative Mg++ binding site [ion binding]; other site 164757015412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757015413 nucleotide binding region [chemical binding]; other site 164757015414 Helicase associated domain (HA2); Region: HA2; pfam04408 164757015415 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 164757015416 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 164757015417 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 164757015418 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 164757015419 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 164757015420 FAD binding domain; Region: FAD_binding_2; pfam00890 164757015421 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 164757015422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 164757015423 Uncharacterized conserved protein [Function unknown]; Region: COG0397 164757015424 hypothetical protein; Validated; Region: PRK00029 164757015425 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 164757015426 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 164757015427 homodimer interface [polypeptide binding]; other site 164757015428 homotetramer interface [polypeptide binding]; other site 164757015429 active site pocket [active] 164757015430 cleavage site 164757015431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757015434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757015435 metal binding site [ion binding]; metal-binding site 164757015436 active site 164757015437 I-site; other site 164757015438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757015440 active site 164757015441 short chain dehydrogenase; Provisional; Region: PRK05872 164757015442 classical (c) SDRs; Region: SDR_c; cd05233 164757015443 NAD(P) binding site [chemical binding]; other site 164757015444 active site 164757015445 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 164757015446 active site 164757015447 metal binding site [ion binding]; metal-binding site 164757015448 selenophosphate synthetase; Provisional; Region: PRK00943 164757015449 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 164757015450 dimerization interface [polypeptide binding]; other site 164757015451 putative ATP binding site [chemical binding]; other site 164757015452 selenocysteine synthase; Provisional; Region: PRK04311 164757015453 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 164757015454 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 164757015455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 164757015456 catalytic residue [active] 164757015457 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 164757015458 G1 box; other site 164757015459 putative GEF interaction site [polypeptide binding]; other site 164757015460 GTP/Mg2+ binding site [chemical binding]; other site 164757015461 Switch I region; other site 164757015462 G2 box; other site 164757015463 G3 box; other site 164757015464 Switch II region; other site 164757015465 G4 box; other site 164757015466 G5 box; other site 164757015467 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 164757015468 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 164757015469 Transcriptional regulator PadR-like family; Region: PadR; cl17335 164757015470 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757015471 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757015472 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757015473 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757015474 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 164757015475 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 164757015476 molybdopterin cofactor binding site; other site 164757015477 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 164757015478 4Fe-4S binding domain; Region: Fer4_6; pfam12837 164757015479 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 164757015480 Cutinase; Region: Cutinase; pfam01083 164757015481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 164757015482 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 164757015483 Uncharacterized conserved protein [Function unknown]; Region: COG0398 164757015484 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 164757015485 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 164757015486 nucleotide binding site [chemical binding]; other site 164757015487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 164757015488 SnoaL-like domain; Region: SnoaL_2; pfam12680 164757015489 short chain dehydrogenase; Provisional; Region: PRK06940 164757015490 classical (c) SDRs; Region: SDR_c; cd05233 164757015491 NAD(P) binding site [chemical binding]; other site 164757015492 active site 164757015493 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 164757015494 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 164757015495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015497 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 164757015498 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757015499 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 164757015500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 164757015501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757015502 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 164757015503 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 164757015504 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 164757015505 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 164757015506 acyl-activating enzyme (AAE) consensus motif; other site 164757015507 active site 164757015508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 164757015509 GAF domain; Region: GAF; pfam01590 164757015510 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757015511 GAF domain; Region: GAF; cl17456 164757015512 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757015513 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 164757015514 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 164757015515 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 164757015516 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 164757015517 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 164757015518 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 164757015519 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 164757015520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015522 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 164757015523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757015524 putative substrate translocation pore; other site 164757015525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 164757015526 MarR family; Region: MarR_2; pfam12802 164757015527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757015528 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 164757015529 NAD(P) binding site [chemical binding]; other site 164757015530 active site 164757015531 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757015532 MarR family; Region: MarR_2; cl17246 164757015533 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 164757015534 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757015535 putative active site [active] 164757015536 putative metal binding site [ion binding]; other site 164757015537 Cupin superfamily protein; Region: Cupin_4; pfam08007 164757015538 Cupin-like domain; Region: Cupin_8; pfam13621 164757015539 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 164757015540 Domain of unknown function DUF302; Region: DUF302; cl01364 164757015541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757015542 NmrA-like family; Region: NmrA; pfam05368 164757015543 NAD(P) binding site [chemical binding]; other site 164757015544 active site 164757015545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015547 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 164757015548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 164757015549 putative substrate translocation pore; other site 164757015550 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 164757015551 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 164757015552 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 164757015553 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 164757015554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 164757015555 ATP binding site [chemical binding]; other site 164757015556 putative Mg++ binding site [ion binding]; other site 164757015557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 164757015558 nucleotide binding region [chemical binding]; other site 164757015559 ATP-binding site [chemical binding]; other site 164757015560 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 164757015561 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 164757015562 putative active site [active] 164757015563 putative CoA binding site [chemical binding]; other site 164757015564 nudix motif; other site 164757015565 metal binding site [ion binding]; metal-binding site 164757015566 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 164757015567 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 164757015568 tetramer interface [polypeptide binding]; other site 164757015569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 164757015570 catalytic residue [active] 164757015571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757015572 dimerization interface [polypeptide binding]; other site 164757015573 putative DNA binding site [nucleotide binding]; other site 164757015574 putative Zn2+ binding site [ion binding]; other site 164757015575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 164757015576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 164757015577 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 164757015578 Part of AAA domain; Region: AAA_19; pfam13245 164757015579 Family description; Region: UvrD_C_2; pfam13538 164757015580 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 164757015581 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 164757015582 active site 164757015583 FMN binding site [chemical binding]; other site 164757015584 substrate binding site [chemical binding]; other site 164757015585 3Fe-4S cluster binding site [ion binding]; other site 164757015586 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 164757015587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 164757015588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 164757015589 metal binding site [ion binding]; metal-binding site 164757015590 active site 164757015591 I-site; other site 164757015592 hypothetical protein; Provisional; Region: PRK06547 164757015593 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 164757015594 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757015595 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757015596 Walker A/P-loop; other site 164757015597 ATP binding site [chemical binding]; other site 164757015598 Q-loop/lid; other site 164757015599 ABC transporter signature motif; other site 164757015600 Walker B; other site 164757015601 D-loop; other site 164757015602 H-loop/switch region; other site 164757015603 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757015604 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 164757015605 Walker A/P-loop; other site 164757015606 ATP binding site [chemical binding]; other site 164757015607 Q-loop/lid; other site 164757015608 ABC transporter signature motif; other site 164757015609 Walker B; other site 164757015610 D-loop; other site 164757015611 H-loop/switch region; other site 164757015612 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 164757015613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015614 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 164757015615 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 164757015616 active site 164757015617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 164757015618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 164757015619 active site 164757015620 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757015621 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757015622 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 164757015623 CoA-transferase family III; Region: CoA_transf_3; pfam02515 164757015624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 164757015625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 164757015626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 164757015627 dimerization interface [polypeptide binding]; other site 164757015628 Cobalt transport protein; Region: CbiQ; cl00463 164757015629 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 164757015630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 164757015631 Walker A/P-loop; other site 164757015632 ATP binding site [chemical binding]; other site 164757015633 Q-loop/lid; other site 164757015634 ABC transporter signature motif; other site 164757015635 Walker B; other site 164757015636 D-loop; other site 164757015637 H-loop/switch region; other site 164757015638 BioY family; Region: BioY; pfam02632 164757015639 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 164757015640 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 164757015641 active site 164757015642 catalytic site [active] 164757015643 Zn binding site [ion binding]; other site 164757015644 tetramer interface [polypeptide binding]; other site 164757015645 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 164757015646 agmatinase; Region: agmatinase; TIGR01230 164757015647 oligomer interface [polypeptide binding]; other site 164757015648 putative active site [active] 164757015649 Mn binding site [ion binding]; other site 164757015650 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 164757015651 classical (c) SDRs; Region: SDR_c; cd05233 164757015652 NAD(P) binding site [chemical binding]; other site 164757015653 active site 164757015654 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757015655 classical (c) SDRs; Region: SDR_c; cd05233 164757015656 NAD(P) binding site [chemical binding]; other site 164757015657 active site 164757015658 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 164757015659 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 164757015660 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 164757015661 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 164757015662 Ferredoxin [Energy production and conversion]; Region: COG1146 164757015663 4Fe-4S binding domain; Region: Fer4; pfam00037 164757015664 Predicted transcriptional regulator [Transcription]; Region: COG2345 164757015665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 164757015666 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 164757015667 heme-binding site [chemical binding]; other site 164757015668 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 164757015669 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 164757015670 Amidase; Region: Amidase; cl11426 164757015671 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 164757015672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757015673 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 164757015674 YCII-related domain; Region: YCII; cl00999 164757015675 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 164757015676 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 164757015677 putative active site [active] 164757015678 putative FMN binding site [chemical binding]; other site 164757015679 putative substrate binding site [chemical binding]; other site 164757015680 putative catalytic residue [active] 164757015681 FAD binding domain; Region: FAD_binding_3; pfam01494 164757015682 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757015683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 164757015684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757015685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757015686 ABC transporter; Region: ABC_tran_2; pfam12848 164757015687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 164757015688 Cutinase; Region: Cutinase; pfam01083 164757015689 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 164757015690 Pirin-related protein [General function prediction only]; Region: COG1741 164757015691 Pirin; Region: Pirin; pfam02678 164757015692 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 164757015693 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 164757015694 classical (c) SDRs; Region: SDR_c; cd05233 164757015695 NAD(P) binding site [chemical binding]; other site 164757015696 active site 164757015697 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 164757015698 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 164757015699 MOSC domain; Region: MOSC; pfam03473 164757015700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757015701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757015704 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 164757015705 active site 164757015706 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 164757015707 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 164757015708 catalytic residues [active] 164757015709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 164757015710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757015711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757015712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 164757015713 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 164757015714 active site residue [active] 164757015715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757015716 active site residue [active] 164757015717 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 164757015718 active site residue [active] 164757015719 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 164757015720 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 164757015721 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 164757015722 putative homodimer interface [polypeptide binding]; other site 164757015723 putative homotetramer interface [polypeptide binding]; other site 164757015724 putative allosteric switch controlling residues; other site 164757015725 putative metal binding site [ion binding]; other site 164757015726 putative homodimer-homodimer interface [polypeptide binding]; other site 164757015727 Predicted membrane protein [Function unknown]; Region: COG2149 164757015728 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 164757015729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 164757015730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 164757015731 motif II; other site 164757015732 Domain of unknown function (DUF305); Region: DUF305; pfam03713 164757015733 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 164757015734 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 164757015735 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 164757015736 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 164757015737 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 164757015738 active site 164757015739 catalytic tetrad [active] 164757015740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 164757015741 MarR family; Region: MarR_2; pfam12802 164757015742 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 164757015743 active site 164757015744 catalytic site [active] 164757015745 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 164757015746 active site 164757015747 catalytic site [active] 164757015748 EVE domain; Region: EVE; cl00728 164757015749 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 164757015750 Transcriptional regulators [Transcription]; Region: FadR; COG2186 164757015751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757015752 DNA-binding site [nucleotide binding]; DNA binding site 164757015753 FCD domain; Region: FCD; pfam07729 164757015754 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 164757015755 AAA domain; Region: AAA_33; pfam13671 164757015756 ATP-binding site [chemical binding]; other site 164757015757 Gluconate-6-phosphate binding site [chemical binding]; other site 164757015758 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 164757015759 fructuronate transporter; Provisional; Region: PRK10034; cl15264 164757015760 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 164757015761 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 164757015762 active site 164757015763 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 164757015764 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 164757015765 putative NAD(P) binding site [chemical binding]; other site 164757015766 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 164757015767 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 164757015768 dimer interface [polypeptide binding]; other site 164757015769 acyl-activating enzyme (AAE) consensus motif; other site 164757015770 putative active site [active] 164757015771 AMP binding site [chemical binding]; other site 164757015772 putative CoA binding site [chemical binding]; other site 164757015773 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 164757015774 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 164757015775 active site 164757015776 FMN binding site [chemical binding]; other site 164757015777 substrate binding site [chemical binding]; other site 164757015778 3Fe-4S cluster binding site [ion binding]; other site 164757015779 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 164757015780 nucleophilic elbow; other site 164757015781 catalytic triad; other site 164757015782 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 164757015783 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 164757015784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 164757015785 putative acyl-acceptor binding pocket; other site 164757015786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015788 short chain dehydrogenase; Provisional; Region: PRK06523 164757015789 classical (c) SDRs; Region: SDR_c; cd05233 164757015790 NAD(P) binding site [chemical binding]; other site 164757015791 active site 164757015792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 164757015793 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 164757015794 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 164757015795 DNA binding residues [nucleotide binding] 164757015796 dimer interface [polypeptide binding]; other site 164757015797 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 164757015798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 164757015799 Mg2+ binding site [ion binding]; other site 164757015800 G-X-G motif; other site 164757015801 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 164757015802 ATP binding site [chemical binding]; other site 164757015803 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 164757015804 active site 164757015805 metal binding site [ion binding]; metal-binding site 164757015806 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 164757015807 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 164757015808 CAP-like domain; other site 164757015809 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 164757015810 active site 164757015811 primary dimer interface [polypeptide binding]; other site 164757015812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 164757015813 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 164757015814 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 164757015815 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 164757015816 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 164757015817 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 164757015818 NAD binding site [chemical binding]; other site 164757015819 ligand binding site [chemical binding]; other site 164757015820 catalytic site [active] 164757015821 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 164757015822 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 164757015823 hypothetical protein; Provisional; Region: PRK06847 164757015824 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 164757015825 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 164757015826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757015827 dimer interface [polypeptide binding]; other site 164757015828 conserved gate region; other site 164757015829 putative PBP binding loops; other site 164757015830 ABC-ATPase subunit interface; other site 164757015831 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 164757015832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 164757015833 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 164757015834 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 164757015835 Walker A/P-loop; other site 164757015836 ATP binding site [chemical binding]; other site 164757015837 Q-loop/lid; other site 164757015838 ABC transporter signature motif; other site 164757015839 Walker B; other site 164757015840 D-loop; other site 164757015841 H-loop/switch region; other site 164757015842 NMT1-like family; Region: NMT1_2; pfam13379 164757015843 NMT1/THI5 like; Region: NMT1; pfam09084 164757015844 membrane-bound complex binding site; other site 164757015845 hinge residues; other site 164757015846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 164757015847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 164757015848 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 164757015849 active site 164757015850 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 164757015851 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 164757015852 putative hydrophobic ligand binding site [chemical binding]; other site 164757015853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 164757015854 dimerization interface [polypeptide binding]; other site 164757015855 putative DNA binding site [nucleotide binding]; other site 164757015856 putative Zn2+ binding site [ion binding]; other site 164757015857 Beta-lactamase; Region: Beta-lactamase; pfam00144 164757015858 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 164757015859 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 164757015860 Domain of unknown function (DUF222); Region: DUF222; pfam02720 164757015861 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 164757015862 active site 164757015863 replicative DNA helicase; Region: DnaB; TIGR00665 164757015864 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 164757015865 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 164757015866 Walker A motif; other site 164757015867 ATP binding site [chemical binding]; other site 164757015868 Walker B motif; other site 164757015869 DNA binding loops [nucleotide binding] 164757015870 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 164757015871 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 164757015872 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 164757015873 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 164757015874 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 164757015875 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 164757015876 dimer interface [polypeptide binding]; other site 164757015877 ssDNA binding site [nucleotide binding]; other site 164757015878 tetramer (dimer of dimers) interface [polypeptide binding]; other site 164757015879 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 164757015880 Predicted integral membrane protein [Function unknown]; Region: COG5650 164757015881 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 164757015882 Transglycosylase; Region: Transgly; pfam00912 164757015883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 164757015884 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 164757015885 Predicted transcriptional regulators [Transcription]; Region: COG1695 164757015886 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 164757015887 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 164757015888 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 164757015889 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 164757015890 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 164757015891 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 164757015892 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 164757015893 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 164757015894 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 164757015895 Transcriptional regulators [Transcription]; Region: GntR; COG1802 164757015896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 164757015897 DNA-binding site [nucleotide binding]; DNA binding site 164757015898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 164757015899 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 164757015900 substrate binding pocket [chemical binding]; other site 164757015901 membrane-bound complex binding site; other site 164757015902 hinge residues; other site 164757015903 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 164757015904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 164757015905 dimer interface [polypeptide binding]; other site 164757015906 conserved gate region; other site 164757015907 putative PBP binding loops; other site 164757015908 ABC-ATPase subunit interface; other site 164757015909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 164757015910 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 164757015911 Walker A/P-loop; other site 164757015912 ATP binding site [chemical binding]; other site 164757015913 Q-loop/lid; other site 164757015914 ABC transporter signature motif; other site 164757015915 Walker B; other site 164757015916 D-loop; other site 164757015917 H-loop/switch region; other site 164757015918 MarR family; Region: MarR; pfam01047 164757015919 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 164757015920 short chain dehydrogenase; Provisional; Region: PRK08219 164757015921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 164757015922 NAD(P) binding site [chemical binding]; other site 164757015923 active site 164757015924 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 164757015925 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 164757015926 putative active site [active] 164757015927 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 164757015928 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 164757015929 HIGH motif; other site 164757015930 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 164757015931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 164757015932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 164757015933 active site 164757015934 KMSKS motif; other site 164757015935 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 164757015936 tRNA binding surface [nucleotide binding]; other site 164757015937 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 164757015938 hypothetical protein; Validated; Region: PRK00228 164757015939 H+ Antiporter protein; Region: 2A0121; TIGR00900 164757015940 TIGR03084 family protein; Region: TIGR03084 164757015941 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 164757015942 Wyosine base formation; Region: Wyosine_form; pfam08608 164757015943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 164757015944 Catalytic domain of Protein Kinases; Region: PKc; cd00180 164757015945 active site 164757015946 ATP binding site [chemical binding]; other site 164757015947 substrate binding site [chemical binding]; other site 164757015948 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 164757015949 substrate binding site [chemical binding]; other site 164757015950 activation loop (A-loop); other site 164757015951 activation loop (A-loop); other site 164757015952 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 164757015953 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 164757015954 active site 164757015955 NTP binding site [chemical binding]; other site 164757015956 metal binding triad [ion binding]; metal-binding site 164757015957 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 164757015958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 164757015959 Zn2+ binding site [ion binding]; other site 164757015960 Mg2+ binding site [ion binding]; other site 164757015961 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 164757015962 active site 164757015963 Ap6A binding site [chemical binding]; other site 164757015964 nudix motif; other site 164757015965 metal binding site [ion binding]; metal-binding site 164757015966 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 164757015967 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 164757015968 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 164757015969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 164757015970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 164757015971 DNA binding residues [nucleotide binding] 164757015972 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 164757015973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 164757015974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 164757015975 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 164757015976 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 164757015977 catalytic residues [active] 164757015978 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 164757015979 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 164757015980 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 164757015981 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 164757015982 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 164757015983 active site 164757015984 metal binding site [ion binding]; metal-binding site 164757015985 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 164757015986 ParB-like nuclease domain; Region: ParBc; pfam02195 164757015987 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 164757015988 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 164757015989 P-loop; other site 164757015990 Magnesium ion binding site [ion binding]; other site 164757015991 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 164757015992 Magnesium ion binding site [ion binding]; other site 164757015993 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 164757015994 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 164757015995 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 164757015996 G-X-X-G motif; other site 164757015997 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 164757015998 RxxxH motif; other site 164757015999 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 164757016000 hypothetical protein; Validated; Region: PRK00041 164757016001 ribonuclease P; Reviewed; Region: rnpA; PRK00588 164757016002 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399