-- dump date 20140619_152841 -- class Genbank::misc_feature -- table misc_feature_note -- id note 189918000001 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 189918000002 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 189918000003 AAA-like domain; Region: AAA_10; pfam12846 189918000004 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 189918000005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000006 Walker A motif; other site 189918000007 ATP binding site [chemical binding]; other site 189918000008 Walker B motif; other site 189918000009 arginine finger; other site 189918000010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 189918000011 sequence-specific DNA binding site [nucleotide binding]; other site 189918000012 salt bridge; other site 189918000013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918000014 putative Mg++ binding site [ion binding]; other site 189918000015 helicase superfamily c-terminal domain; Region: HELICc; smart00490 189918000016 Helicase associated domain; Region: HA; pfam03457 189918000017 Helicase associated domain; Region: HA; pfam03457 189918000018 Helicase associated domain; Region: HA; pfam03457 189918000019 Helicase associated domain; Region: HA; pfam03457 189918000020 Helicase associated domain; Region: HA; pfam03457 189918000021 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918000022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918000023 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918000024 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 189918000025 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 189918000026 ATP binding site [chemical binding]; other site 189918000027 Divergent AAA domain; Region: AAA_4; pfam04326 189918000028 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 189918000029 TrwC relaxase; Region: TrwC; pfam08751 189918000030 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 189918000031 AAA domain; Region: AAA_30; pfam13604 189918000032 Family description; Region: UvrD_C_2; pfam13538 189918000033 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918000034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918000035 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918000036 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 189918000037 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918000038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918000039 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918000040 YodL-like; Region: YodL; pfam14191 189918000041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918000042 non-specific DNA binding site [nucleotide binding]; other site 189918000043 salt bridge; other site 189918000044 sequence-specific DNA binding site [nucleotide binding]; other site 189918000045 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918000047 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918000048 replicative DNA helicase; Validated; Region: PRK07773 189918000049 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 189918000050 catalytic residues [active] 189918000051 ParB-like nuclease domain; Region: ParB; smart00470 189918000052 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 189918000053 DNA-binding interface [nucleotide binding]; DNA binding site 189918000054 Domain of unknown function (DUF932); Region: DUF932; pfam06067 189918000055 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918000056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918000057 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918000058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918000059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918000060 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189918000061 ABC1 family; Region: ABC1; pfam03109 189918000062 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189918000063 ABC1 family; Region: ABC1; pfam03109 189918000064 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 189918000065 active site 189918000066 ATP binding site [chemical binding]; other site 189918000067 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918000068 Cytochrome P450; Region: p450; cl12078 189918000069 MMPL family; Region: MMPL; pfam03176 189918000070 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 189918000071 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 189918000072 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918000073 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918000074 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189918000075 catalytic site [active] 189918000076 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 189918000077 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 189918000078 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 189918000079 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 189918000080 active site 189918000081 catalytic residues [active] 189918000082 DNA binding site [nucleotide binding] 189918000083 Int/Topo IB signature motif; other site 189918000084 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 189918000085 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 189918000086 active site 189918000087 DNA binding site [nucleotide binding] 189918000088 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 189918000089 DNA binding site [nucleotide binding] 189918000090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918000091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918000092 active site 189918000093 ATP binding site [chemical binding]; other site 189918000094 substrate binding site [chemical binding]; other site 189918000095 activation loop (A-loop); other site 189918000096 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 189918000097 putative active site [active] 189918000098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918000099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918000100 non-specific DNA binding site [nucleotide binding]; other site 189918000101 salt bridge; other site 189918000102 sequence-specific DNA binding site [nucleotide binding]; other site 189918000103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918000104 putative substrate translocation pore; other site 189918000105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918000106 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 189918000107 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 189918000108 AAA domain; Region: AAA_22; pfam13401 189918000109 ATP-binding site [chemical binding]; other site 189918000110 Helix-turn-helix domain; Region: HTH_28; pfam13518 189918000111 Winged helix-turn helix; Region: HTH_29; pfam13551 189918000112 Homeodomain-like domain; Region: HTH_32; pfam13565 189918000113 Integrase core domain; Region: rve; pfam00665 189918000114 Integrase core domain; Region: rve_3; pfam13683 189918000115 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 189918000116 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000117 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 189918000118 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 189918000119 ParB-like nuclease domain; Region: ParB; smart00470 189918000120 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918000121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000122 P-loop; other site 189918000123 Magnesium ion binding site [ion binding]; other site 189918000124 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918000125 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000126 P-loop; other site 189918000127 Magnesium ion binding site [ion binding]; other site 189918000128 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000129 Magnesium ion binding site [ion binding]; other site 189918000130 Helix-turn-helix domain; Region: HTH_36; pfam13730 189918000131 Transcription factor WhiB; Region: Whib; pfam02467 189918000132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 189918000133 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 189918000134 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189918000135 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189918000136 catalytic residue [active] 189918000137 Helix-turn-helix domain; Region: HTH_28; pfam13518 189918000138 Winged helix-turn helix; Region: HTH_29; pfam13551 189918000139 Integrase core domain; Region: rve; pfam00665 189918000140 Integrase core domain; Region: rve_3; cl15866 189918000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 189918000142 AAA domain; Region: AAA_22; pfam13401 189918000143 TniQ; Region: TniQ; pfam06527 189918000144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918000145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918000146 non-specific DNA binding site [nucleotide binding]; other site 189918000147 salt bridge; other site 189918000148 sequence-specific DNA binding site [nucleotide binding]; other site 189918000149 TniQ; Region: TniQ; pfam06527 189918000150 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 189918000151 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 189918000152 RES domain; Region: RES; cl02411 189918000153 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918000154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918000155 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918000157 Thioredoxin; Region: Thioredoxin_4; pfam13462 189918000158 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 189918000159 Transposase; Region: HTH_Tnp_1; pfam01527 189918000160 HTH-like domain; Region: HTH_21; pfam13276 189918000161 Integrase core domain; Region: rve; pfam00665 189918000162 Integrase core domain; Region: rve_3; pfam13683 189918000163 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918000164 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918000165 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000166 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918000167 iron-sulfur cluster [ion binding]; other site 189918000168 [2Fe-2S] cluster binding site [ion binding]; other site 189918000169 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000170 beta subunit interface [polypeptide binding]; other site 189918000171 alpha subunit interface [polypeptide binding]; other site 189918000172 active site 189918000173 substrate binding site [chemical binding]; other site 189918000174 Fe binding site [ion binding]; other site 189918000175 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000176 inter-subunit interface; other site 189918000177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189918000178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189918000179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189918000180 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 189918000181 active site 189918000182 metal binding site [ion binding]; metal-binding site 189918000183 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 189918000184 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 189918000185 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 189918000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918000187 NAD(P) binding site [chemical binding]; other site 189918000188 active site 189918000189 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 189918000190 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 189918000191 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 189918000192 active site 189918000193 Fe binding site [ion binding]; other site 189918000194 SCP-2 sterol transfer family; Region: SCP2; pfam02036 189918000195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 189918000196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918000197 salt bridge; other site 189918000198 non-specific DNA binding site [nucleotide binding]; other site 189918000199 sequence-specific DNA binding site [nucleotide binding]; other site 189918000200 Integrase core domain; Region: rve; pfam00665 189918000201 transposase/IS protein; Provisional; Region: PRK09183 189918000202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000203 Walker A motif; other site 189918000204 ATP binding site [chemical binding]; other site 189918000205 Walker B motif; other site 189918000206 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000207 inter-subunit interface; other site 189918000208 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 189918000209 L-aspartate oxidase; Provisional; Region: PRK06175 189918000210 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918000211 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 189918000212 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189918000213 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918000214 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 189918000215 NAD(P) binding site [chemical binding]; other site 189918000216 catalytic residues [active] 189918000217 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000218 inter-subunit interface; other site 189918000219 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000220 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918000221 alpha subunit interaction site [polypeptide binding]; other site 189918000222 beta subunit interaction site [polypeptide binding]; other site 189918000223 iron-sulfur cluster [ion binding]; other site 189918000224 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000225 beta subunit interface [polypeptide binding]; other site 189918000226 alpha subunit interface [polypeptide binding]; other site 189918000227 active site 189918000228 substrate binding site [chemical binding]; other site 189918000229 Fe binding site [ion binding]; other site 189918000230 short chain dehydrogenase; Provisional; Region: PRK06138 189918000231 classical (c) SDRs; Region: SDR_c; cd05233 189918000232 NAD(P) binding site [chemical binding]; other site 189918000233 active site 189918000234 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918000235 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 189918000236 putative NAD(P) binding site [chemical binding]; other site 189918000237 catalytic Zn binding site [ion binding]; other site 189918000238 VPS10 domain; Region: VPS10; smart00602 189918000239 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000240 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918000241 [2Fe-2S] cluster binding site [ion binding]; other site 189918000242 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918000243 hydrophobic ligand binding site; other site 189918000244 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918000245 SCP-2 sterol transfer family; Region: SCP2; cl01225 189918000246 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918000247 active site 189918000248 Permease; Region: Permease; pfam02405 189918000249 Epoxide hydrolase N terminus; Region: EHN; pfam06441 189918000250 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918000251 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918000252 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 189918000253 NAD(P) binding site [chemical binding]; other site 189918000254 catalytic residues [active] 189918000255 catalytic residues [active] 189918000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918000257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918000258 putative substrate translocation pore; other site 189918000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 189918000260 MarR family; Region: MarR; pfam01047 189918000261 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000262 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918000263 alpha subunit interaction site [polypeptide binding]; other site 189918000264 beta subunit interaction site [polypeptide binding]; other site 189918000265 iron-sulfur cluster [ion binding]; other site 189918000266 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000267 beta subunit interface [polypeptide binding]; other site 189918000268 alpha subunit interface [polypeptide binding]; other site 189918000269 active site 189918000270 substrate binding site [chemical binding]; other site 189918000271 Fe binding site [ion binding]; other site 189918000272 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000273 inter-subunit interface; other site 189918000274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918000275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918000276 lipid-transfer protein; Provisional; Region: PRK07855 189918000277 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918000278 active site 189918000279 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918000280 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918000281 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918000282 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918000283 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918000284 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 189918000285 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918000286 iron-sulfur cluster [ion binding]; other site 189918000287 [2Fe-2S] cluster binding site [ion binding]; other site 189918000288 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000289 beta subunit interface [polypeptide binding]; other site 189918000290 alpha subunit interface [polypeptide binding]; other site 189918000291 active site 189918000292 substrate binding site [chemical binding]; other site 189918000293 Fe binding site [ion binding]; other site 189918000294 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000295 inter-subunit interface; other site 189918000296 Cupin domain; Region: Cupin_2; pfam07883 189918000297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918000298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918000299 MarR family; Region: MarR; pfam01047 189918000300 MarR family; Region: MarR_2; cl17246 189918000301 putative transposase OrfB; Reviewed; Region: PHA02517 189918000302 HTH-like domain; Region: HTH_21; pfam13276 189918000303 Integrase core domain; Region: rve; pfam00665 189918000304 Integrase core domain; Region: rve_3; cl15866 189918000305 HTH-like domain; Region: HTH_21; pfam13276 189918000306 Integrase core domain; Region: rve; pfam00665 189918000307 Integrase core domain; Region: rve_3; pfam13683 189918000308 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 189918000309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189918000310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189918000311 CAAX protease self-immunity; Region: Abi; pfam02517 189918000312 CopC domain; Region: CopC; pfam04234 189918000313 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918000314 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918000315 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 189918000316 Subunit I/III interface [polypeptide binding]; other site 189918000317 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189918000318 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918000319 catalytic residues [active] 189918000320 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 189918000321 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918000322 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 189918000323 Penicillinase repressor; Region: Pencillinase_R; pfam03965 189918000324 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189918000325 Peptidase family M23; Region: Peptidase_M23; pfam01551 189918000326 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 189918000327 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 189918000328 D-pathway; other site 189918000329 Putative ubiquinol binding site [chemical binding]; other site 189918000330 Low-spin heme (heme b) binding site [chemical binding]; other site 189918000331 Putative water exit pathway; other site 189918000332 Binuclear center (heme o3/CuB) [ion binding]; other site 189918000333 K-pathway; other site 189918000334 Putative proton exit pathway; other site 189918000335 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 189918000336 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918000337 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 189918000338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918000339 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918000340 cyclase homology domain; Region: CHD; cd07302 189918000341 nucleotidyl binding site; other site 189918000342 metal binding site [ion binding]; metal-binding site 189918000343 dimer interface [polypeptide binding]; other site 189918000344 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 189918000345 Predicted membrane protein [Function unknown]; Region: COG3462 189918000346 Short C-terminal domain; Region: SHOCT; pfam09851 189918000347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189918000348 dimerization interface [polypeptide binding]; other site 189918000349 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918000350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918000351 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918000352 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 189918000353 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 189918000354 Copper resistance protein D; Region: CopD; pfam05425 189918000355 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 189918000356 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918000357 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 189918000358 Thioredoxin; Region: Thioredoxin_4; pfam13462 189918000359 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 189918000360 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918000361 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918000362 cyclase homology domain; Region: CHD; cd07302 189918000363 nucleotidyl binding site; other site 189918000364 metal binding site [ion binding]; metal-binding site 189918000365 dimer interface [polypeptide binding]; other site 189918000366 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 189918000367 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918000368 Helix-turn-helix domain; Region: HTH_18; pfam12833 189918000369 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189918000370 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189918000371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918000372 dimerization interface [polypeptide binding]; other site 189918000373 putative DNA binding site [nucleotide binding]; other site 189918000374 putative Zn2+ binding site [ion binding]; other site 189918000375 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 189918000376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918000377 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918000378 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 189918000379 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189918000380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918000381 metal-binding site [ion binding] 189918000382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918000383 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918000384 Domain of unknown function DUF302; Region: DUF302; pfam03625 189918000385 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918000386 HAMP domain; Region: HAMP; pfam00672 189918000387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918000388 dimer interface [polypeptide binding]; other site 189918000389 phosphorylation site [posttranslational modification] 189918000390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918000391 ATP binding site [chemical binding]; other site 189918000392 Mg2+ binding site [ion binding]; other site 189918000393 G-X-G motif; other site 189918000394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918000395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918000396 active site 189918000397 phosphorylation site [posttranslational modification] 189918000398 intermolecular recognition site; other site 189918000399 dimerization interface [polypeptide binding]; other site 189918000400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918000401 DNA binding site [nucleotide binding] 189918000402 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 189918000403 Multicopper oxidase; Region: Cu-oxidase; pfam00394 189918000404 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 189918000405 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 189918000406 Predicted membrane protein [Function unknown]; Region: COG3462 189918000407 Short C-terminal domain; Region: SHOCT; pfam09851 189918000408 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189918000409 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918000410 metal-binding site [ion binding] 189918000411 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918000412 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918000413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918000414 metal-binding site [ion binding] 189918000415 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918000416 putative homodimer interface [polypeptide binding]; other site 189918000417 putative homotetramer interface [polypeptide binding]; other site 189918000418 putative allosteric switch controlling residues; other site 189918000419 putative metal binding site [ion binding]; other site 189918000420 putative homodimer-homodimer interface [polypeptide binding]; other site 189918000421 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189918000422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918000423 Walker A/P-loop; other site 189918000424 ATP binding site [chemical binding]; other site 189918000425 Q-loop/lid; other site 189918000426 ABC transporter signature motif; other site 189918000427 Walker B; other site 189918000428 D-loop; other site 189918000429 H-loop/switch region; other site 189918000430 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918000431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918000433 active site 189918000434 phosphorylation site [posttranslational modification] 189918000435 intermolecular recognition site; other site 189918000436 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 189918000437 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918000438 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918000439 Penicillinase repressor; Region: Pencillinase_R; cl17580 189918000440 Peptidase family M48; Region: Peptidase_M48; cl12018 189918000441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918000442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918000443 DNA binding site [nucleotide binding] 189918000444 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918000445 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918000446 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918000447 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918000448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918000449 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918000450 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189918000451 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189918000452 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 189918000453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918000454 Mg2+ binding site [ion binding]; other site 189918000455 G-X-G motif; other site 189918000456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 189918000457 Integrase core domain; Region: rve_3; pfam13683 189918000458 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000459 MULE transposase domain; Region: MULE; pfam10551 189918000460 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000461 MULE transposase domain; Region: MULE; pfam10551 189918000462 Predicted membrane protein [Function unknown]; Region: COG3462 189918000463 Short C-terminal domain; Region: SHOCT; pfam09851 189918000464 BNR repeat-like domain; Region: BNR_2; pfam13088 189918000465 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918000466 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918000467 cyclase homology domain; Region: CHD; cd07302 189918000468 nucleotidyl binding site; other site 189918000469 metal binding site [ion binding]; metal-binding site 189918000470 dimer interface [polypeptide binding]; other site 189918000471 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 189918000472 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918000473 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189918000474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918000475 S-adenosylmethionine binding site [chemical binding]; other site 189918000476 Helix-turn-helix domain; Region: HTH_18; pfam12833 189918000477 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189918000478 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189918000479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918000480 dimerization interface [polypeptide binding]; other site 189918000481 putative DNA binding site [nucleotide binding]; other site 189918000482 putative Zn2+ binding site [ion binding]; other site 189918000483 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 189918000484 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918000485 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918000486 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 189918000487 Cadmium resistance transporter; Region: Cad; pfam03596 189918000488 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189918000489 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918000490 catalytic residues [active] 189918000491 AMP-binding enzyme; Region: AMP-binding; pfam00501 189918000492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918000493 active site 189918000494 CoA binding site [chemical binding]; other site 189918000495 AMP binding site [chemical binding]; other site 189918000496 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918000497 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 189918000498 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 189918000499 Walker A/P-loop; other site 189918000500 ATP binding site [chemical binding]; other site 189918000501 Q-loop/lid; other site 189918000502 ABC transporter signature motif; other site 189918000503 Walker B; other site 189918000504 D-loop; other site 189918000505 H-loop/switch region; other site 189918000506 TOBE domain; Region: TOBE_2; pfam08402 189918000507 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 189918000508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918000509 dimer interface [polypeptide binding]; other site 189918000510 conserved gate region; other site 189918000511 ABC-ATPase subunit interface; other site 189918000512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918000513 dimer interface [polypeptide binding]; other site 189918000514 conserved gate region; other site 189918000515 ABC-ATPase subunit interface; other site 189918000516 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 189918000517 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 189918000518 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 189918000519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918000520 active site residue [active] 189918000521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918000522 active site residue [active] 189918000523 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918000524 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918000525 putative homotetramer interface [polypeptide binding]; other site 189918000526 putative homodimer interface [polypeptide binding]; other site 189918000527 putative allosteric switch controlling residues; other site 189918000528 putative metal binding site [ion binding]; other site 189918000529 putative homodimer-homodimer interface [polypeptide binding]; other site 189918000530 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000531 MULE transposase domain; Region: MULE; pfam10551 189918000532 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 189918000533 5' RNA guide strand anchoring site; other site 189918000534 active site 189918000535 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 189918000536 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 189918000537 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 189918000538 FIC domain binding interface [polypeptide binding]; other site 189918000539 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 189918000540 Fic/DOC family; Region: Fic; cl00960 189918000541 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918000542 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918000543 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 189918000544 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 189918000545 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 189918000546 PPE family; Region: PPE; pfam00823 189918000547 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 189918000548 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000549 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 189918000550 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000551 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000552 PPE family; Region: PPE; pfam00823 189918000553 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 189918000554 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918000555 EspG family; Region: ESX-1_EspG; pfam14011 189918000556 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 189918000557 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 189918000558 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 189918000559 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 189918000560 catalytic residues [active] 189918000561 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 189918000562 active site 189918000563 catalytic residues [active] 189918000564 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 189918000565 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000566 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 189918000567 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 189918000568 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 189918000569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 189918000570 ATP binding site [chemical binding]; other site 189918000571 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 189918000572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 189918000573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918000574 S-adenosylmethionine binding site [chemical binding]; other site 189918000575 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 189918000576 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 189918000577 AAA domain; Region: AAA_30; pfam13604 189918000578 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 189918000579 AAA domain; Region: AAA_12; pfam13087 189918000580 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 189918000581 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 189918000582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000583 Walker A motif; other site 189918000584 ATP binding site [chemical binding]; other site 189918000585 Walker B motif; other site 189918000586 arginine finger; other site 189918000587 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 189918000588 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189918000589 Active Sites [active] 189918000590 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000591 MULE transposase domain; Region: MULE; pfam10551 189918000592 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 189918000593 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 189918000594 DNA binding residues [nucleotide binding] 189918000595 putative transposase OrfB; Reviewed; Region: PHA02517 189918000596 HTH-like domain; Region: HTH_21; pfam13276 189918000597 Integrase core domain; Region: rve; pfam00665 189918000598 Integrase core domain; Region: rve_3; pfam13683 189918000599 Integrase core domain; Region: rve_3; pfam13683 189918000600 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000601 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918000602 Integrase core domain; Region: rve; pfam00665 189918000603 HTH-like domain; Region: HTH_21; pfam13276 189918000604 Integrase core domain; Region: rve; pfam00665 189918000605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189918000606 Transposase; Region: HTH_Tnp_1; cl17663 189918000607 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000608 MULE transposase domain; Region: MULE; pfam10551 189918000609 Integrase core domain; Region: rve_3; cl15866 189918000610 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918000611 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 189918000612 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918000613 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 189918000614 acetaldehyde dehydrogenase; Validated; Region: PRK08300 189918000615 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 189918000616 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 189918000617 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 189918000618 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 189918000619 active site 189918000620 catalytic residues [active] 189918000621 metal binding site [ion binding]; metal-binding site 189918000622 DmpG-like communication domain; Region: DmpG_comm; pfam07836 189918000623 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918000624 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918000625 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000626 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918000627 iron-sulfur cluster [ion binding]; other site 189918000628 [2Fe-2S] cluster binding site [ion binding]; other site 189918000629 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000630 beta subunit interface [polypeptide binding]; other site 189918000631 alpha subunit interface [polypeptide binding]; other site 189918000632 active site 189918000633 substrate binding site [chemical binding]; other site 189918000634 Fe binding site [ion binding]; other site 189918000635 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000636 inter-subunit interface; other site 189918000637 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189918000638 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189918000639 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189918000640 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 189918000641 active site 189918000642 metal binding site [ion binding]; metal-binding site 189918000643 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 189918000644 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 189918000645 intersubunit interface [polypeptide binding]; other site 189918000646 active site 189918000647 Zn2+ binding site [ion binding]; other site 189918000648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918000649 MarR family; Region: MarR; pfam01047 189918000650 MarR family; Region: MarR_2; cl17246 189918000651 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918000652 Cupin domain; Region: Cupin_2; pfam07883 189918000653 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000654 inter-subunit interface; other site 189918000655 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918000656 iron-sulfur cluster [ion binding]; other site 189918000657 [2Fe-2S] cluster binding site [ion binding]; other site 189918000658 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000659 beta subunit interface [polypeptide binding]; other site 189918000660 alpha subunit interface [polypeptide binding]; other site 189918000661 active site 189918000662 substrate binding site [chemical binding]; other site 189918000663 Fe binding site [ion binding]; other site 189918000664 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918000665 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918000666 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918000667 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918000668 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918000669 lipid-transfer protein; Provisional; Region: PRK07855 189918000670 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918000671 active site 189918000672 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918000673 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918000674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918000675 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 189918000676 putative NAD(P) binding site [chemical binding]; other site 189918000677 catalytic Zn binding site [ion binding]; other site 189918000678 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918000679 inter-subunit interface; other site 189918000680 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918000681 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918000682 alpha subunit interaction site [polypeptide binding]; other site 189918000683 beta subunit interaction site [polypeptide binding]; other site 189918000684 iron-sulfur cluster [ion binding]; other site 189918000685 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918000686 beta subunit interface [polypeptide binding]; other site 189918000687 alpha subunit interface [polypeptide binding]; other site 189918000688 active site 189918000689 substrate binding site [chemical binding]; other site 189918000690 Fe binding site [ion binding]; other site 189918000691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000692 MULE transposase domain; Region: MULE; pfam10551 189918000693 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000694 MULE transposase domain; Region: MULE; pfam10551 189918000695 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 189918000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918000698 replicative DNA helicase; Region: DnaB; TIGR00665 189918000699 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 189918000700 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 189918000701 Walker A motif; other site 189918000702 ATP binding site [chemical binding]; other site 189918000703 Walker B motif; other site 189918000704 DNA binding loops [nucleotide binding] 189918000705 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 189918000706 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 189918000707 Transcription factor WhiB; Region: Whib; pfam02467 189918000708 Transcription factor WhiB; Region: Whib; pfam02467 189918000709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918000710 non-specific DNA binding site [nucleotide binding]; other site 189918000711 salt bridge; other site 189918000712 sequence-specific DNA binding site [nucleotide binding]; other site 189918000713 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 189918000714 active site 189918000715 catalytic site [active] 189918000716 substrate binding site [chemical binding]; other site 189918000717 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 189918000718 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 189918000719 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 189918000720 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 189918000721 active site 189918000722 Fe-S cluster binding site [ion binding]; other site 189918000723 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 189918000724 Protein of unknown function (DUF499); Region: DUF499; pfam04465 189918000725 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 189918000726 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918000727 DEAD-like helicases superfamily; Region: DEXDc; smart00487 189918000728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918000729 ATP binding site [chemical binding]; other site 189918000730 putative Mg++ binding site [ion binding]; other site 189918000731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918000732 nucleotide binding region [chemical binding]; other site 189918000733 ATP-binding site [chemical binding]; other site 189918000734 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 189918000735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 189918000736 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 189918000737 putative active site [active] 189918000738 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000739 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918000740 Integrase core domain; Region: rve; pfam00665 189918000741 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 189918000742 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 189918000743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918000744 motif II; other site 189918000745 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 189918000746 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000747 MULE transposase domain; Region: MULE; pfam10551 189918000748 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918000749 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918000750 active site 189918000751 ATP binding site [chemical binding]; other site 189918000752 substrate binding site [chemical binding]; other site 189918000753 activation loop (A-loop); other site 189918000754 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 189918000755 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 189918000756 active site 189918000757 DNA binding site [nucleotide binding] 189918000758 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 189918000759 DNA binding site [nucleotide binding] 189918000760 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 189918000761 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 189918000762 putative active site [active] 189918000763 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 189918000764 HerA helicase [Replication, recombination, and repair]; Region: COG0433 189918000765 Cutinase; Region: Cutinase; pfam01083 189918000766 AAA-like domain; Region: AAA_10; pfam12846 189918000767 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120 189918000768 Walker A motif; other site 189918000769 ATP binding site [chemical binding]; other site 189918000770 Walker B motif; other site 189918000771 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 189918000772 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 189918000773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000774 Walker A motif; other site 189918000775 ATP binding site [chemical binding]; other site 189918000776 Walker B motif; other site 189918000777 arginine finger; other site 189918000778 Protein of unknown function (DUF690); Region: DUF690; cl04939 189918000779 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 189918000780 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000781 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 189918000782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000783 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 189918000784 PPE family; Region: PPE; pfam00823 189918000785 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918000786 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918000787 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 189918000788 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 189918000789 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 189918000790 active site 189918000791 catalytic residues [active] 189918000792 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 189918000793 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 189918000794 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 189918000795 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000796 P-loop; other site 189918000797 Magnesium ion binding site [ion binding]; other site 189918000798 EspG family; Region: ESX-1_EspG; pfam14011 189918000799 ParB-like nuclease domain; Region: ParB; smart00470 189918000800 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000801 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918000802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918000803 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 189918000804 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 189918000805 catalytic residues [active] 189918000806 catalytic nucleophile [active] 189918000807 Recombinase; Region: Recombinase; pfam07508 189918000808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000809 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918000810 Walker A motif; other site 189918000811 ATP binding site [chemical binding]; other site 189918000812 Walker B motif; other site 189918000813 arginine finger; other site 189918000814 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 189918000815 active site 189918000816 catalytic triad [active] 189918000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918000818 Walker B; other site 189918000819 D-loop; other site 189918000820 H-loop/switch region; other site 189918000821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918000822 MULE transposase domain; Region: MULE; pfam10551 189918000823 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 189918000824 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 189918000825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918000826 active site 189918000827 DNA binding site [nucleotide binding] 189918000828 Int/Topo IB signature motif; other site 189918000829 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 189918000830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918000831 active site 189918000832 DNA binding site [nucleotide binding] 189918000833 Int/Topo IB signature motif; other site 189918000834 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000835 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918000836 Integrase core domain; Region: rve; pfam00665 189918000837 HTH-like domain; Region: HTH_21; pfam13276 189918000838 Integrase core domain; Region: rve; pfam00665 189918000839 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 189918000840 putative transposase OrfB; Reviewed; Region: PHA02517 189918000841 Integrase core domain; Region: rve; pfam00665 189918000842 Transposase; Region: HTH_Tnp_1; cl17663 189918000843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189918000844 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 189918000845 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918000846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918000847 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 189918000848 nudix motif; other site 189918000849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918000850 Zn2+ binding site [ion binding]; other site 189918000851 Mg2+ binding site [ion binding]; other site 189918000852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918000853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918000854 Transport protein; Region: actII; TIGR00833 189918000855 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 189918000856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189918000857 Transposase; Region: HTH_Tnp_1; cl17663 189918000858 HTH-like domain; Region: HTH_21; pfam13276 189918000859 Integrase core domain; Region: rve; pfam00665 189918000860 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918000861 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918000862 Integrase core domain; Region: rve; pfam00665 189918000863 Integrase core domain; Region: rve_3; pfam13683 189918000864 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 189918000865 TPP-binding site [chemical binding]; other site 189918000866 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 189918000867 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 189918000868 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 189918000869 beta-clamp/clamp loader binding surface; other site 189918000870 Protein of unknown function (DUF615); Region: DUF615; cl01147 189918000871 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 189918000872 ParB-like nuclease domain; Region: ParBc; pfam02195 189918000873 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918000874 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000875 P-loop; other site 189918000876 Magnesium ion binding site [ion binding]; other site 189918000877 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918000878 Magnesium ion binding site [ion binding]; other site 189918000879 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 189918000880 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 189918000881 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 189918000882 G-X-X-G motif; other site 189918000883 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 189918000884 RxxxH motif; other site 189918000885 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 189918000886 hypothetical protein; Validated; Region: PRK00041 189918000887 ribonuclease P; Reviewed; Region: rnpA; PRK00588 189918000888 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 189918000889 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 189918000890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918000891 Walker A motif; other site 189918000892 ATP binding site [chemical binding]; other site 189918000893 Walker B motif; other site 189918000894 arginine finger; other site 189918000895 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 189918000896 DnaA box-binding interface [nucleotide binding]; other site 189918000897 DNA polymerase III subunit beta; Validated; Region: PRK07761 189918000898 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 189918000899 putative DNA binding surface [nucleotide binding]; other site 189918000900 dimer interface [polypeptide binding]; other site 189918000901 beta-clamp/clamp loader binding surface; other site 189918000902 beta-clamp/translesion DNA polymerase binding surface; other site 189918000903 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918000904 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 189918000905 recombination protein F; Reviewed; Region: recF; PRK00064 189918000906 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 189918000907 Walker A/P-loop; other site 189918000908 ATP binding site [chemical binding]; other site 189918000909 Q-loop/lid; other site 189918000910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918000911 ABC transporter signature motif; other site 189918000912 Walker B; other site 189918000913 D-loop; other site 189918000914 H-loop/switch region; other site 189918000915 hypothetical protein; Provisional; Region: PRK03195 189918000916 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 189918000917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918000918 Mg2+ binding site [ion binding]; other site 189918000919 G-X-G motif; other site 189918000920 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 189918000921 anchoring element; other site 189918000922 dimer interface [polypeptide binding]; other site 189918000923 ATP binding site [chemical binding]; other site 189918000924 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 189918000925 active site 189918000926 putative metal-binding site [ion binding]; other site 189918000927 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 189918000928 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 189918000929 CAP-like domain; other site 189918000930 active site 189918000931 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 189918000932 protein-splicing catalytic site; other site 189918000933 thioester formation/cholesterol transfer; other site 189918000934 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 189918000935 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 189918000936 DNA gyrase subunit A; Validated; Region: PRK05560 189918000937 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 189918000938 primary dimer interface [polypeptide binding]; other site 189918000939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000941 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000942 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000944 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918000945 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 189918000946 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 189918000947 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 189918000948 active site 189918000949 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 189918000950 putative septation inhibitor protein; Reviewed; Region: PRK00159 189918000951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 189918000952 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 189918000953 Glutamine amidotransferase class-I; Region: GATase; pfam00117 189918000954 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 189918000955 glutamine binding [chemical binding]; other site 189918000956 catalytic triad [active] 189918000957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918000958 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918000959 active site 189918000960 ATP binding site [chemical binding]; other site 189918000961 substrate binding site [chemical binding]; other site 189918000962 activation loop (A-loop); other site 189918000963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 189918000964 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918000965 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918000966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918000967 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918000968 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918000969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918000970 active site 189918000971 ATP binding site [chemical binding]; other site 189918000972 substrate binding site [chemical binding]; other site 189918000973 activation loop (A-loop); other site 189918000974 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 189918000975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189918000976 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 189918000977 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 189918000978 active site 189918000979 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918000980 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918000981 phosphopeptide binding site; other site 189918000982 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 189918000983 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918000984 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918000985 phosphopeptide binding site; other site 189918000986 HsdM N-terminal domain; Region: HsdM_N; pfam12161 189918000987 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 189918000988 Methyltransferase domain; Region: Methyltransf_26; pfam13659 189918000989 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 189918000990 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 189918000991 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 189918000992 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 189918000993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918000994 ATP binding site [chemical binding]; other site 189918000995 putative Mg++ binding site [ion binding]; other site 189918000996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 189918000997 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 189918000998 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 189918000999 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 189918001000 ligand binding site [chemical binding]; other site 189918001001 active site 189918001002 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918001003 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918001004 active site 189918001005 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918001006 MULE transposase domain; Region: MULE; pfam10551 189918001007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918001008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918001009 active site 189918001010 catalytic tetrad [active] 189918001011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001013 hypothetical protein; Validated; Region: PRK07581 189918001014 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 189918001015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001017 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 189918001018 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 189918001019 putative NADP binding site [chemical binding]; other site 189918001020 putative substrate binding site [chemical binding]; other site 189918001021 active site 189918001022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001023 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918001024 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001025 active site 189918001026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001027 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001028 active site 189918001029 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 189918001030 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918001031 active site 189918001032 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918001033 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918001034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918001035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001036 NAD(P) binding site [chemical binding]; other site 189918001037 active site 189918001038 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 189918001039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 189918001040 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 189918001041 DNA binding residues [nucleotide binding] 189918001042 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 189918001043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918001044 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918001045 phosphopeptide binding site; other site 189918001046 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918001047 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918001048 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918001049 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918001050 PHB binding site; other site 189918001051 CoenzymeA binding site [chemical binding]; other site 189918001052 subunit interaction site [polypeptide binding]; other site 189918001053 Predicted acetyltransferase [General function prediction only]; Region: COG2388 189918001054 hypothetical protein; Provisional; Region: PRK02268 189918001055 DivIVA domain; Region: DivI1A_domain; TIGR03544 189918001056 DivIVA domain; Region: DivI1A_domain; TIGR03544 189918001057 Transcription factor WhiB; Region: Whib; pfam02467 189918001058 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918001059 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 189918001060 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 189918001061 EspG family; Region: ESX-1_EspG; pfam14011 189918001062 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 189918001063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918001064 Walker A motif; other site 189918001065 ATP binding site [chemical binding]; other site 189918001066 Walker B motif; other site 189918001067 arginine finger; other site 189918001068 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 189918001069 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 189918001070 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918001071 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 189918001072 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918001074 Walker A motif; other site 189918001075 ATP binding site [chemical binding]; other site 189918001076 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 189918001077 PPE family; Region: PPE; pfam00823 189918001078 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918001079 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918001080 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 189918001081 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 189918001082 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 189918001083 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 189918001084 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 189918001085 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 189918001086 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 189918001087 active site 189918001088 catalytic residues [active] 189918001089 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 189918001090 dimerization domain swap beta strand [polypeptide binding]; other site 189918001091 regulatory protein interface [polypeptide binding]; other site 189918001092 active site 189918001093 regulatory phosphorylation site [posttranslational modification]; other site 189918001094 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 189918001095 active site 189918001096 phosphorylation site [posttranslational modification] 189918001097 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 189918001098 active site 189918001099 P-loop; other site 189918001100 phosphorylation site [posttranslational modification] 189918001101 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 189918001102 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 189918001103 putative substrate binding site [chemical binding]; other site 189918001104 putative ATP binding site [chemical binding]; other site 189918001105 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 189918001106 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 189918001107 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 189918001108 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 189918001109 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 189918001110 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 189918001111 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 189918001112 Pirin-related protein [General function prediction only]; Region: COG1741 189918001113 Pirin; Region: Pirin; pfam02678 189918001114 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 189918001115 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 189918001116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001120 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918001121 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 189918001122 Leucine carboxyl methyltransferase; Region: LCM; cl01306 189918001123 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918001124 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 189918001125 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 189918001126 NAD(P) binding site [chemical binding]; other site 189918001127 catalytic residues [active] 189918001128 short chain dehydrogenase; Provisional; Region: PRK07791 189918001129 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 189918001130 NAD binding site [chemical binding]; other site 189918001131 homodimer interface [polypeptide binding]; other site 189918001132 active site 189918001133 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918001134 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 189918001135 NAD(P) binding site [chemical binding]; other site 189918001136 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 189918001137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918001138 motif II; other site 189918001139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918001140 S-adenosylmethionine binding site [chemical binding]; other site 189918001141 Protein of unknown function (DUF456); Region: DUF456; pfam04306 189918001142 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 189918001143 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 189918001144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001146 active site 189918001147 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001149 active site 189918001150 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 189918001151 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 189918001152 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 189918001153 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 189918001154 ligand binding site [chemical binding]; other site 189918001155 homodimer interface [polypeptide binding]; other site 189918001156 NAD(P) binding site [chemical binding]; other site 189918001157 trimer interface B [polypeptide binding]; other site 189918001158 trimer interface A [polypeptide binding]; other site 189918001159 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 189918001160 short chain dehydrogenase; Provisional; Region: PRK07806 189918001161 glucose-1-dehydrogenase; Provisional; Region: PRK06947 189918001162 NAD(P) binding site [chemical binding]; other site 189918001163 active site 189918001164 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 189918001165 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 189918001166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918001167 dimer interface [polypeptide binding]; other site 189918001168 conserved gate region; other site 189918001169 putative PBP binding loops; other site 189918001170 ABC-ATPase subunit interface; other site 189918001171 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 189918001172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918001173 substrate binding pocket [chemical binding]; other site 189918001174 membrane-bound complex binding site; other site 189918001175 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 189918001176 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 189918001177 Walker A/P-loop; other site 189918001178 ATP binding site [chemical binding]; other site 189918001179 Q-loop/lid; other site 189918001180 ABC transporter signature motif; other site 189918001181 Walker B; other site 189918001182 D-loop; other site 189918001183 H-loop/switch region; other site 189918001184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001187 active site 189918001188 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 189918001189 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 189918001190 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918001191 NAD(P) binding site [chemical binding]; other site 189918001192 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189918001193 active site 189918001194 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918001195 putative hydrophobic ligand binding site [chemical binding]; other site 189918001196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918001197 DNA-binding site [nucleotide binding]; DNA binding site 189918001198 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 189918001199 FCD domain; Region: FCD; pfam07729 189918001200 Restriction endonuclease; Region: Mrr_cat; pfam04471 189918001201 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 189918001202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918001203 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918001204 acyl-activating enzyme (AAE) consensus motif; other site 189918001205 putative AMP binding site [chemical binding]; other site 189918001206 putative active site [active] 189918001207 putative CoA binding site [chemical binding]; other site 189918001208 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918001209 Permease; Region: Permease; pfam02405 189918001210 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918001211 Permease; Region: Permease; pfam02405 189918001212 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001213 mce related protein; Region: MCE; pfam02470 189918001214 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918001215 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001216 mce related protein; Region: MCE; pfam02470 189918001217 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918001218 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001219 mce related protein; Region: MCE; pfam02470 189918001220 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 189918001221 mce related protein; Region: MCE; pfam02470 189918001222 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001223 mce related protein; Region: MCE; pfam02470 189918001224 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001225 mce related protein; Region: MCE; pfam02470 189918001226 RDD family; Region: RDD; pfam06271 189918001227 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 189918001228 Phosphotransferase enzyme family; Region: APH; pfam01636 189918001229 Fructosamine kinase; Region: Fructosamin_kin; cl17579 189918001230 PE-PPE domain; Region: PE-PPE; pfam08237 189918001231 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918001232 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 189918001233 Predicted membrane protein [Function unknown]; Region: COG2261 189918001234 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 189918001235 Pirin-related protein [General function prediction only]; Region: COG1741 189918001236 Pirin; Region: Pirin; pfam02678 189918001237 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918001238 MarR family; Region: MarR_2; pfam12802 189918001239 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 189918001240 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918001241 NAD binding site [chemical binding]; other site 189918001242 catalytic Zn binding site [ion binding]; other site 189918001243 substrate binding site [chemical binding]; other site 189918001244 structural Zn binding site [ion binding]; other site 189918001245 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 189918001246 putative active site [active] 189918001247 RNA polymerase factor sigma-70; Validated; Region: PRK08241 189918001248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918001249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918001250 DNA binding residues [nucleotide binding] 189918001251 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918001252 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 189918001253 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918001254 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 189918001255 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 189918001256 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 189918001257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918001258 S-adenosylmethionine binding site [chemical binding]; other site 189918001259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918001260 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 189918001261 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918001262 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918001263 putative homodimer interface [polypeptide binding]; other site 189918001264 putative homotetramer interface [polypeptide binding]; other site 189918001265 putative allosteric switch controlling residues; other site 189918001266 putative metal binding site [ion binding]; other site 189918001267 putative homodimer-homodimer interface [polypeptide binding]; other site 189918001268 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 189918001269 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 189918001270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918001271 putative substrate translocation pore; other site 189918001272 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918001274 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918001275 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 189918001276 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918001277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918001278 Walker A motif; other site 189918001279 ATP binding site [chemical binding]; other site 189918001280 Walker B motif; other site 189918001281 arginine finger; other site 189918001282 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 189918001283 Protein of unknown function DUF58; Region: DUF58; pfam01882 189918001284 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 189918001285 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 189918001286 active site 189918001287 Zn binding site [ion binding]; other site 189918001288 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 189918001289 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 189918001290 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918001291 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 189918001292 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918001294 active site 189918001295 phosphorylation site [posttranslational modification] 189918001296 intermolecular recognition site; other site 189918001297 dimerization interface [polypeptide binding]; other site 189918001298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918001299 DNA binding site [nucleotide binding] 189918001300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918001301 HAMP domain; Region: HAMP; pfam00672 189918001302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918001303 phosphorylation site [posttranslational modification] 189918001304 dimer interface [polypeptide binding]; other site 189918001305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918001306 ATP binding site [chemical binding]; other site 189918001307 Mg2+ binding site [ion binding]; other site 189918001308 G-X-G motif; other site 189918001309 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 189918001310 Predicted integral membrane protein [Function unknown]; Region: COG0392 189918001311 Domain of unknown function DUF20; Region: UPF0118; pfam01594 189918001312 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 189918001313 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918001314 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918001315 active site 189918001316 MMPL family; Region: MMPL; pfam03176 189918001317 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 189918001318 MMPL family; Region: MMPL; pfam03176 189918001319 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 189918001320 LabA_like proteins; Region: LabA_like; cd06167 189918001321 putative metal binding site [ion binding]; other site 189918001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918001323 S-adenosylmethionine binding site [chemical binding]; other site 189918001324 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 189918001325 active site 189918001326 substrate-binding site [chemical binding]; other site 189918001327 metal-binding site [ion binding] 189918001328 GTP binding site [chemical binding]; other site 189918001329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918001330 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 189918001331 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918001332 acyl-activating enzyme (AAE) consensus motif; other site 189918001333 putative AMP binding site [chemical binding]; other site 189918001334 putative active site [active] 189918001335 acyl-activating enzyme (AAE) consensus motif; other site 189918001336 putative CoA binding site [chemical binding]; other site 189918001337 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918001338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918001339 substrate binding site [chemical binding]; other site 189918001340 oxyanion hole (OAH) forming residues; other site 189918001341 trimer interface [polypeptide binding]; other site 189918001342 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 189918001343 classical (c) SDRs; Region: SDR_c; cd05233 189918001344 NAD(P) binding site [chemical binding]; other site 189918001345 active site 189918001346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 189918001347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 189918001348 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 189918001349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001350 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001351 active site 189918001352 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 189918001353 putative active site [active] 189918001354 putative catalytic site [active] 189918001355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918001356 active site 2 [active] 189918001357 active site 1 [active] 189918001358 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918001359 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 189918001360 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918001361 active site 189918001362 Ion channel; Region: Ion_trans_2; pfam07885 189918001363 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 189918001364 tetramer interface [polypeptide binding]; other site 189918001365 active site 189918001366 Mg2+/Mn2+ binding site [ion binding]; other site 189918001367 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 189918001368 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918001369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001370 NAD(P) binding site [chemical binding]; other site 189918001371 active site 189918001372 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 189918001373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918001374 DNA-binding site [nucleotide binding]; DNA binding site 189918001375 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 189918001376 short chain dehydrogenase; Provisional; Region: PRK12829 189918001377 classical (c) SDRs; Region: SDR_c; cd05233 189918001378 NAD(P) binding site [chemical binding]; other site 189918001379 active site 189918001380 Phosphotransferase enzyme family; Region: APH; pfam01636 189918001381 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 189918001382 substrate binding site [chemical binding]; other site 189918001383 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 189918001384 putative hexamer interface [polypeptide binding]; other site 189918001385 putative hexagonal pore; other site 189918001386 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 189918001387 putative hexamer interface [polypeptide binding]; other site 189918001388 putative hexagonal pore; other site 189918001389 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 189918001390 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 189918001391 Hexamer interface [polypeptide binding]; other site 189918001392 Hexagonal pore residue; other site 189918001393 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 189918001394 Hexamer/Pentamer interface [polypeptide binding]; other site 189918001395 central pore; other site 189918001396 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 189918001397 putative hexamer interface [polypeptide binding]; other site 189918001398 putative hexagonal pore; other site 189918001399 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 189918001400 putative hexamer interface [polypeptide binding]; other site 189918001401 putative hexagonal pore; other site 189918001402 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 189918001403 putative catalytic cysteine [active] 189918001404 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 189918001405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918001406 inhibitor-cofactor binding pocket; inhibition site 189918001407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918001408 catalytic residue [active] 189918001409 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918001410 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918001411 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918001412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001415 active site 189918001416 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 189918001417 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918001418 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918001419 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918001420 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918001421 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918001422 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918001423 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918001424 substrate binding pocket [chemical binding]; other site 189918001425 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918001426 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918001427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918001428 putative acyl-acceptor binding pocket; other site 189918001429 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 189918001430 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 189918001431 CsbD-like; Region: CsbD; pfam05532 189918001432 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 189918001433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001437 active site 189918001438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918001439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918001440 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 189918001441 RibD C-terminal domain; Region: RibD_C; cl17279 189918001442 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 189918001443 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918001444 NAD binding site [chemical binding]; other site 189918001445 catalytic residues [active] 189918001446 Methyltransferase domain; Region: Methyltransf_11; pfam08241 189918001447 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918001448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918001449 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 189918001450 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918001451 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 189918001452 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918001453 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918001454 putative AMP binding site [chemical binding]; other site 189918001455 putative active site [active] 189918001456 acyl-activating enzyme (AAE) consensus motif; other site 189918001457 putative CoA binding site [chemical binding]; other site 189918001458 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 189918001459 active site 189918001460 substrate binding pocket [chemical binding]; other site 189918001461 homodimer interaction site [polypeptide binding]; other site 189918001462 Transmembrane secretion effector; Region: MFS_3; pfam05977 189918001463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918001464 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 189918001465 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 189918001466 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 189918001467 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918001468 Ligand Binding Site [chemical binding]; other site 189918001469 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 189918001470 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 189918001471 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 189918001472 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918001473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918001474 catalytic residue [active] 189918001475 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 189918001476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918001477 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918001478 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 189918001479 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918001480 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 189918001481 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 189918001482 putative dimer interface [polypeptide binding]; other site 189918001483 putative active site [active] 189918001484 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 189918001485 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 189918001486 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 189918001487 putative active site [active] 189918001488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001490 O-methyltransferase; Region: Methyltransf_2; pfam00891 189918001491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918001492 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918001493 active site 2 [active] 189918001494 active site 1 [active] 189918001495 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 189918001496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001497 NAD(P) binding site [chemical binding]; other site 189918001498 active site 189918001499 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 189918001500 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918001501 dimer interface [polypeptide binding]; other site 189918001502 active site 189918001503 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 189918001504 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 189918001505 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 189918001506 FAD binding site [chemical binding]; other site 189918001507 substrate binding site [chemical binding]; other site 189918001508 catalytic residues [active] 189918001509 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 189918001510 GAF domain; Region: GAF; cl17456 189918001511 ANTAR domain; Region: ANTAR; pfam03861 189918001512 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918001513 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918001514 active site 189918001515 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918001516 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918001517 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 189918001518 KR domain; Region: KR; pfam08659 189918001519 NADP binding site [chemical binding]; other site 189918001520 active site 189918001521 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918001522 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 189918001523 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918001524 active site 189918001525 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918001526 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 189918001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001528 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 189918001529 Enoylreductase; Region: PKS_ER; smart00829 189918001530 NAD(P) binding site [chemical binding]; other site 189918001531 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 189918001532 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 189918001533 putative NADP binding site [chemical binding]; other site 189918001534 active site 189918001535 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918001536 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918001537 acyl-CoA synthetase; Validated; Region: PRK05850 189918001538 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918001539 acyl-activating enzyme (AAE) consensus motif; other site 189918001540 active site 189918001541 PE-PPE domain; Region: PE-PPE; pfam08237 189918001542 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 189918001543 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 189918001544 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 189918001545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918001546 catalytic loop [active] 189918001547 iron binding site [ion binding]; other site 189918001548 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 189918001549 L-aspartate oxidase; Provisional; Region: PRK06175 189918001550 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918001551 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 189918001552 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 189918001553 tetramer interface [polypeptide binding]; other site 189918001554 active site 189918001555 Mg2+/Mn2+ binding site [ion binding]; other site 189918001556 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 189918001557 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 189918001558 putative dimer interface [polypeptide binding]; other site 189918001559 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 189918001560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918001561 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 189918001562 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918001563 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 189918001564 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 189918001565 GAF domain; Region: GAF_2; pfam13185 189918001566 ANTAR domain; Region: ANTAR; pfam03861 189918001567 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 189918001568 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 189918001569 putative active site [active] 189918001570 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 189918001571 putative active site [active] 189918001572 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 189918001573 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 189918001574 active site 189918001575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 189918001576 DNA binding site [nucleotide binding] 189918001577 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 189918001578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918001579 Coenzyme A binding pocket [chemical binding]; other site 189918001580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918001581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918001582 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 189918001583 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 189918001584 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 189918001585 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 189918001586 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 189918001587 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 189918001588 intersubunit interface [polypeptide binding]; other site 189918001589 short chain dehydrogenase; Provisional; Region: PRK08267 189918001590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001591 NAD(P) binding site [chemical binding]; other site 189918001592 active site 189918001593 Lysine efflux permease [General function prediction only]; Region: COG1279 189918001594 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918001595 Permease; Region: Permease; pfam02405 189918001596 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918001597 Permease; Region: Permease; pfam02405 189918001598 mce related protein; Region: MCE; pfam02470 189918001599 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918001600 mce related protein; Region: MCE; pfam02470 189918001601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001602 mce related protein; Region: MCE; pfam02470 189918001603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918001604 mce related protein; Region: MCE; pfam02470 189918001605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001607 mce related protein; Region: MCE; pfam02470 189918001608 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918001609 mce related protein; Region: MCE; pfam02470 189918001610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918001611 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918001612 CoenzymeA binding site [chemical binding]; other site 189918001613 subunit interaction site [polypeptide binding]; other site 189918001614 PHB binding site; other site 189918001615 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 189918001616 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918001617 Predicted transcriptional regulators [Transcription]; Region: COG1695 189918001618 Transcriptional regulator PadR-like family; Region: PadR; cl17335 189918001619 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 189918001620 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 189918001621 active site 189918001622 FMN binding site [chemical binding]; other site 189918001623 substrate binding site [chemical binding]; other site 189918001624 putative catalytic residue [active] 189918001625 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918001626 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918001627 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918001628 classical (c) SDRs; Region: SDR_c; cd05233 189918001629 NAD(P) binding site [chemical binding]; other site 189918001630 active site 189918001631 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 189918001632 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918001633 short chain dehydrogenase; Provisional; Region: PRK12828 189918001634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001635 NAD(P) binding site [chemical binding]; other site 189918001636 active site 189918001637 SnoaL-like domain; Region: SnoaL_4; pfam13577 189918001638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918001639 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 189918001640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918001641 hydrophobic ligand binding site; other site 189918001642 short chain dehydrogenase; Provisional; Region: PRK12828 189918001643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001644 NAD(P) binding site [chemical binding]; other site 189918001645 active site 189918001646 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918001647 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918001648 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918001649 hypothetical protein; Validated; Region: PRK07121 189918001650 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918001651 classical (c) SDRs; Region: SDR_c; cd05233 189918001652 short chain dehydrogenase; Provisional; Region: PRK08267 189918001653 NAD(P) binding site [chemical binding]; other site 189918001654 active site 189918001655 classical (c) SDRs; Region: SDR_c; cd05233 189918001656 NAD(P) binding site [chemical binding]; other site 189918001657 active site 189918001658 enoyl-CoA hydratase; Provisional; Region: PRK09245 189918001659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918001660 substrate binding site [chemical binding]; other site 189918001661 oxyanion hole (OAH) forming residues; other site 189918001662 trimer interface [polypeptide binding]; other site 189918001663 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 189918001664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918001665 NAD binding site [chemical binding]; other site 189918001666 catalytic residues [active] 189918001667 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 189918001668 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918001669 catalytic Zn binding site [ion binding]; other site 189918001670 structural Zn binding site [ion binding]; other site 189918001671 tetramer interface [polypeptide binding]; other site 189918001672 acyl-CoA synthetase; Validated; Region: PRK08316 189918001673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918001674 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918001675 acyl-activating enzyme (AAE) consensus motif; other site 189918001676 putative AMP binding site [chemical binding]; other site 189918001677 putative active site [active] 189918001678 putative CoA binding site [chemical binding]; other site 189918001679 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918001680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918001681 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 189918001682 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189918001683 NAD(P) binding site [chemical binding]; other site 189918001684 homodimer interface [polypeptide binding]; other site 189918001685 active site 189918001686 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 189918001687 putative allyl alcohol dehydrogenase; Provisional; Region: PLN03154 189918001688 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918001689 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918001690 substrate binding pocket [chemical binding]; other site 189918001691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918001692 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918001693 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 189918001694 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918001695 hypothetical protein; Validated; Region: PRK07121 189918001696 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918001697 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 189918001698 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 189918001699 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 189918001700 active site 189918001701 Fe binding site [ion binding]; other site 189918001702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001704 active site 189918001705 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 189918001706 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 189918001707 FAD binding pocket [chemical binding]; other site 189918001708 FAD binding motif [chemical binding]; other site 189918001709 phosphate binding motif [ion binding]; other site 189918001710 beta-alpha-beta structure motif; other site 189918001711 NAD(p) ribose binding residues [chemical binding]; other site 189918001712 NAD binding pocket [chemical binding]; other site 189918001713 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 189918001714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918001715 catalytic loop [active] 189918001716 iron binding site [ion binding]; other site 189918001717 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918001718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918001719 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 189918001720 classical (c) SDRs; Region: SDR_c; cd05233 189918001721 NAD(P) binding site [chemical binding]; other site 189918001722 active site 189918001723 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918001724 classical (c) SDRs; Region: SDR_c; cd05233 189918001725 NAD(P) binding site [chemical binding]; other site 189918001726 active site 189918001727 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 189918001728 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918001729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001731 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918001732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918001733 putative substrate translocation pore; other site 189918001734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001735 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189918001736 NAD(P) binding site [chemical binding]; other site 189918001737 active site 189918001738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918001739 Ligand Binding Site [chemical binding]; other site 189918001740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918001741 Ligand Binding Site [chemical binding]; other site 189918001742 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918001743 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918001744 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918001745 classical (c) SDRs; Region: SDR_c; cd05233 189918001746 NAD(P) binding site [chemical binding]; other site 189918001747 active site 189918001748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001750 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918001751 Cytochrome P450; Region: p450; cl12078 189918001752 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 189918001753 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 189918001754 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918001755 classical (c) SDRs; Region: SDR_c; cd05233 189918001756 NAD(P) binding site [chemical binding]; other site 189918001757 active site 189918001758 short chain dehydrogenase; Provisional; Region: PRK12827 189918001759 classical (c) SDRs; Region: SDR_c; cd05233 189918001760 NAD(P) binding site [chemical binding]; other site 189918001761 active site 189918001762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001764 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 189918001765 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918001766 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918001767 active site 189918001768 Transcriptional regulators [Transcription]; Region: GntR; COG1802 189918001769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918001770 DNA-binding site [nucleotide binding]; DNA binding site 189918001771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 189918001772 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 189918001773 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 189918001774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 189918001775 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 189918001776 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 189918001777 active site 189918001778 hypothetical protein; Provisional; Region: PRK06062 189918001779 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918001780 inhibitor-cofactor binding pocket; inhibition site 189918001781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918001782 catalytic residue [active] 189918001783 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 189918001784 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 189918001785 tetrameric interface [polypeptide binding]; other site 189918001786 NAD binding site [chemical binding]; other site 189918001787 catalytic residues [active] 189918001788 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 189918001789 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918001790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918001791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918001792 dimer interface [polypeptide binding]; other site 189918001793 phosphorylation site [posttranslational modification] 189918001794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918001795 ATP binding site [chemical binding]; other site 189918001796 Mg2+ binding site [ion binding]; other site 189918001797 G-X-G motif; other site 189918001798 Response regulator receiver domain; Region: Response_reg; pfam00072 189918001799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918001800 active site 189918001801 phosphorylation site [posttranslational modification] 189918001802 intermolecular recognition site; other site 189918001803 dimerization interface [polypeptide binding]; other site 189918001804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189918001805 PAS domain; Region: PAS_9; pfam13426 189918001806 putative active site [active] 189918001807 heme pocket [chemical binding]; other site 189918001808 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918001809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 189918001810 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189918001811 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918001812 anti sigma factor interaction site; other site 189918001813 regulatory phosphorylation site [posttranslational modification]; other site 189918001814 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 189918001815 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 189918001816 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 189918001817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918001818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 189918001819 dimerization interface [polypeptide binding]; other site 189918001820 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 189918001821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918001822 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918001823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918001824 metal binding site [ion binding]; metal-binding site 189918001825 active site 189918001826 I-site; other site 189918001827 Putative transcription activator [Transcription]; Region: TenA; COG0819 189918001828 Methyltransferase domain; Region: Methyltransf_24; pfam13578 189918001829 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918001830 anti sigma factor interaction site; other site 189918001831 regulatory phosphorylation site [posttranslational modification]; other site 189918001832 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 189918001833 nucleotide binding site [chemical binding]; other site 189918001834 acyl-CoA synthetase; Validated; Region: PRK07788 189918001835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918001836 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918001837 acyl-activating enzyme (AAE) consensus motif; other site 189918001838 acyl-activating enzyme (AAE) consensus motif; other site 189918001839 putative AMP binding site [chemical binding]; other site 189918001840 putative active site [active] 189918001841 putative CoA binding site [chemical binding]; other site 189918001842 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 189918001843 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 189918001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918001845 putative substrate translocation pore; other site 189918001846 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 189918001847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918001849 active site 189918001850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918001851 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 189918001852 FAD binding site [chemical binding]; other site 189918001853 substrate binding site [chemical binding]; other site 189918001854 catalytic base [active] 189918001855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001857 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 189918001858 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918001859 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 189918001860 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 189918001861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918001862 Walker A motif; other site 189918001863 ATP binding site [chemical binding]; other site 189918001864 Walker B motif; other site 189918001865 arginine finger; other site 189918001866 Protein of unknown function (DUF690); Region: DUF690; cl04939 189918001867 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 189918001868 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918001869 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 189918001870 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918001871 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918001872 PE family; Region: PE; pfam00934 189918001873 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 189918001874 PPE family; Region: PPE; pfam00823 189918001875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 189918001876 EspG family; Region: ESX-1_EspG; pfam14011 189918001877 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 189918001878 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 189918001879 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 189918001880 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 189918001881 active site 189918001882 catalytic residues [active] 189918001883 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 189918001884 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 189918001885 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 189918001886 NAD(P) binding site [chemical binding]; other site 189918001887 LDH/MDH dimer interface [polypeptide binding]; other site 189918001888 substrate binding site [chemical binding]; other site 189918001889 pyruvate kinase; Provisional; Region: PRK14725 189918001890 active site 189918001891 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 189918001892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918001893 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 189918001894 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 189918001895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918001896 S-adenosylmethionine binding site [chemical binding]; other site 189918001897 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 189918001898 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 189918001899 CysD dimerization site [polypeptide binding]; other site 189918001900 G1 box; other site 189918001901 putative GEF interaction site [polypeptide binding]; other site 189918001902 GTP/Mg2+ binding site [chemical binding]; other site 189918001903 Switch I region; other site 189918001904 G2 box; other site 189918001905 G3 box; other site 189918001906 Switch II region; other site 189918001907 G4 box; other site 189918001908 G5 box; other site 189918001909 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 189918001910 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 189918001911 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 189918001912 ligand-binding site [chemical binding]; other site 189918001913 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 189918001914 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189918001915 Active Sites [active] 189918001916 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 189918001917 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189918001918 Sulfatase; Region: Sulfatase; pfam00884 189918001919 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918001920 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 189918001921 active site 189918001922 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 189918001923 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 189918001924 active site 189918001925 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 189918001926 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 189918001927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918001928 putative DNA binding site [nucleotide binding]; other site 189918001929 putative Zn2+ binding site [ion binding]; other site 189918001930 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 189918001931 putative hydrophobic ligand binding site [chemical binding]; other site 189918001932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 189918001933 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918001934 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918001935 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918001936 iron-sulfur cluster [ion binding]; other site 189918001937 [2Fe-2S] cluster binding site [ion binding]; other site 189918001938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918001939 nucleotide binding site [chemical binding]; other site 189918001940 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 189918001941 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 189918001942 putative di-iron ligands [ion binding]; other site 189918001943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918001944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918001945 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918001946 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 189918001947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918001948 GAF domain; Region: GAF; pfam01590 189918001949 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189918001950 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918001951 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 189918001952 DXD motif; other site 189918001953 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918001954 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 189918001955 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918001956 anti sigma factor interaction site; other site 189918001957 regulatory phosphorylation site [posttranslational modification]; other site 189918001958 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189918001959 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 189918001960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918001961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918001962 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 189918001963 PE-PPE domain; Region: PE-PPE; pfam08237 189918001964 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 189918001965 active site 189918001966 catalytic residues [active] 189918001967 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 189918001968 PE-PPE domain; Region: PE-PPE; pfam08237 189918001969 PE-PPE domain; Region: PE-PPE; pfam08237 189918001970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918001971 MULE transposase domain; Region: MULE; pfam10551 189918001972 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918001973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001974 NAD(P) binding site [chemical binding]; other site 189918001975 active site 189918001976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918001977 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918001978 NAD(P) binding site [chemical binding]; other site 189918001979 active site 189918001980 Secretory lipase; Region: LIP; pfam03583 189918001981 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189918001982 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 189918001983 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918001984 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918001985 active site 189918001986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918001987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918001988 dimerization interface [polypeptide binding]; other site 189918001989 DNA binding residues [nucleotide binding] 189918001990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918001991 S-adenosylmethionine binding site [chemical binding]; other site 189918001992 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 189918001993 trimer interface [polypeptide binding]; other site 189918001994 active site 189918001995 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 189918001996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918001997 Cytochrome P450; Region: p450; cl12078 189918001998 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918001999 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918002000 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918002001 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 189918002002 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 189918002003 substrate binding site; other site 189918002004 tetramer interface; other site 189918002005 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 189918002006 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 189918002007 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 189918002008 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 189918002009 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 189918002010 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 189918002011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918002012 catalytic loop [active] 189918002013 iron binding site [ion binding]; other site 189918002014 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 189918002015 YibE/F-like protein; Region: YibE_F; pfam07907 189918002016 aminotransferase AlaT; Validated; Region: PRK09265 189918002017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918002018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918002019 homodimer interface [polypeptide binding]; other site 189918002020 catalytic residue [active] 189918002021 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 189918002022 4Fe-4S binding domain; Region: Fer4; cl02805 189918002023 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 189918002024 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 189918002025 4Fe-4S binding domain; Region: Fer4; pfam00037 189918002026 Cysteine-rich domain; Region: CCG; pfam02754 189918002027 Cysteine-rich domain; Region: CCG; pfam02754 189918002028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918002029 dimerization interface [polypeptide binding]; other site 189918002030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918002031 DNA binding residues [nucleotide binding] 189918002032 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918002033 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 189918002034 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 189918002035 G1 box; other site 189918002036 GTP/Mg2+ binding site [chemical binding]; other site 189918002037 G2 box; other site 189918002038 Switch I region; other site 189918002039 G3 box; other site 189918002040 Switch II region; other site 189918002041 G4 box; other site 189918002042 G5 box; other site 189918002043 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 189918002044 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 189918002045 G1 box; other site 189918002046 GTP/Mg2+ binding site [chemical binding]; other site 189918002047 G2 box; other site 189918002048 Switch I region; other site 189918002049 G3 box; other site 189918002050 Switch II region; other site 189918002051 G4 box; other site 189918002052 G5 box; other site 189918002053 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918002054 nucleotide binding site [chemical binding]; other site 189918002055 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918002056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918002057 TIGR03085 family protein; Region: TIGR03085 189918002058 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 189918002059 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 189918002060 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918002061 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918002062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918002063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918002064 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918002065 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 189918002066 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 189918002067 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 189918002068 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 189918002069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918002070 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 189918002071 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 189918002072 nucleotide binding site [chemical binding]; other site 189918002073 NEF interaction site [polypeptide binding]; other site 189918002074 SBD interface [polypeptide binding]; other site 189918002075 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 189918002076 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 189918002077 dimer interface [polypeptide binding]; other site 189918002078 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 189918002079 chaperone protein DnaJ; Provisional; Region: PRK14279 189918002080 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 189918002081 HSP70 interaction site [polypeptide binding]; other site 189918002082 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 189918002083 Zn binding sites [ion binding]; other site 189918002084 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 189918002085 dimer interface [polypeptide binding]; other site 189918002086 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 189918002087 DNA binding residues [nucleotide binding] 189918002088 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918002089 putative dimer interface [polypeptide binding]; other site 189918002090 mannosyltransferase; Provisional; Region: pimE; PRK13375 189918002091 mannosyltransferase; Provisional; Region: pimE; PRK13375 189918002092 mannosyltransferase; Provisional; Region: pimE; PRK13375 189918002093 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 189918002094 active site 189918002095 catalytic residues [active] 189918002096 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 189918002097 heme-binding site [chemical binding]; other site 189918002098 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 189918002099 FMN reductase; Validated; Region: fre; PRK08051 189918002100 FAD binding pocket [chemical binding]; other site 189918002101 FAD binding motif [chemical binding]; other site 189918002102 phosphate binding motif [ion binding]; other site 189918002103 beta-alpha-beta structure motif; other site 189918002104 NAD binding pocket [chemical binding]; other site 189918002105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002107 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 189918002108 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 189918002109 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 189918002110 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 189918002111 Clp amino terminal domain; Region: Clp_N; pfam02861 189918002112 Clp amino terminal domain; Region: Clp_N; pfam02861 189918002113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918002114 Walker A motif; other site 189918002115 ATP binding site [chemical binding]; other site 189918002116 Walker B motif; other site 189918002117 arginine finger; other site 189918002118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918002119 Walker A motif; other site 189918002120 ATP binding site [chemical binding]; other site 189918002121 Walker B motif; other site 189918002122 arginine finger; other site 189918002123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 189918002124 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918002125 classical (c) SDRs; Region: SDR_c; cd05233 189918002126 NAD(P) binding site [chemical binding]; other site 189918002127 active site 189918002128 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189918002129 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189918002130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918002131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918002132 putative substrate translocation pore; other site 189918002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918002134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002136 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 189918002137 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 189918002138 Thioredoxin; Region: Thioredoxin_4; pfam13462 189918002139 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 189918002140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918002141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918002142 LysR substrate binding domain; Region: LysR_substrate; pfam03466 189918002143 dimerization interface [polypeptide binding]; other site 189918002144 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 189918002145 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 189918002146 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 189918002147 XdhC Rossmann domain; Region: XdhC_C; pfam13478 189918002148 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 189918002149 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 189918002150 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 189918002151 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 189918002152 catalytic loop [active] 189918002153 iron binding site [ion binding]; other site 189918002154 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 189918002155 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 189918002156 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 189918002157 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 189918002158 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 189918002159 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 189918002160 XdhC Rossmann domain; Region: XdhC_C; pfam13478 189918002161 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918002162 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 189918002163 putative hydrophobic ligand binding site [chemical binding]; other site 189918002164 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 189918002165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 189918002166 metal ion-dependent adhesion site (MIDAS); other site 189918002167 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918002168 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 189918002169 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918002170 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 189918002171 short chain dehydrogenase; Validated; Region: PRK08264 189918002172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918002173 NAD(P) binding site [chemical binding]; other site 189918002174 active site 189918002175 Nitronate monooxygenase; Region: NMO; pfam03060 189918002176 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918002177 FMN binding site [chemical binding]; other site 189918002178 substrate binding site [chemical binding]; other site 189918002179 putative catalytic residue [active] 189918002180 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 189918002181 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 189918002182 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189918002183 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918002184 NAD(P) binding site [chemical binding]; other site 189918002185 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 189918002186 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 189918002187 active site 189918002188 intersubunit interface [polypeptide binding]; other site 189918002189 zinc binding site [ion binding]; other site 189918002190 Na+ binding site [ion binding]; other site 189918002191 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 189918002192 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 189918002193 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 189918002194 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 189918002195 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 189918002196 Peptidase family M50; Region: Peptidase_M50; pfam02163 189918002197 active site 189918002198 putative substrate binding region [chemical binding]; other site 189918002199 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918002201 DNA-binding site [nucleotide binding]; DNA binding site 189918002202 FCD domain; Region: FCD; pfam07729 189918002203 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 189918002204 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 189918002205 catalytic triad [active] 189918002206 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 189918002207 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 189918002208 active site 189918002209 metal binding site [ion binding]; metal-binding site 189918002210 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918002211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918002212 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 189918002213 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189918002214 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918002215 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918002216 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 189918002217 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 189918002218 GDP-binding site [chemical binding]; other site 189918002219 ACT binding site; other site 189918002220 IMP binding site; other site 189918002221 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918002222 CoenzymeA binding site [chemical binding]; other site 189918002223 subunit interaction site [polypeptide binding]; other site 189918002224 PHB binding site; other site 189918002225 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918002226 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918002227 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918002228 Cytochrome P450; Region: p450; cl12078 189918002229 MMPL family; Region: MMPL; pfam03176 189918002230 MMPL family; Region: MMPL; pfam03176 189918002231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918002232 MarR family; Region: MarR_2; pfam12802 189918002233 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 189918002234 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 189918002235 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 189918002236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918002237 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 189918002238 active site residue [active] 189918002239 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 189918002240 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 189918002241 homodimer interface [polypeptide binding]; other site 189918002242 substrate-cofactor binding pocket; other site 189918002243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918002244 catalytic residue [active] 189918002245 short chain dehydrogenase; Provisional; Region: PRK07825 189918002246 classical (c) SDRs; Region: SDR_c; cd05233 189918002247 NAD(P) binding site [chemical binding]; other site 189918002248 active site 189918002249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918002250 Coenzyme A binding pocket [chemical binding]; other site 189918002251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918002252 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 189918002253 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 189918002254 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918002255 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 189918002256 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 189918002257 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 189918002258 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189918002259 DXD motif; other site 189918002260 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 189918002261 phosphate acetyltransferase; Reviewed; Region: PRK05632 189918002262 DRTGG domain; Region: DRTGG; pfam07085 189918002263 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 189918002264 propionate/acetate kinase; Provisional; Region: PRK12379 189918002265 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 189918002266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918002267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918002268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918002269 active site 189918002270 ATP binding site [chemical binding]; other site 189918002271 substrate binding site [chemical binding]; other site 189918002272 activation loop (A-loop); other site 189918002273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918002274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918002275 substrate binding pocket [chemical binding]; other site 189918002276 membrane-bound complex binding site; other site 189918002277 hinge residues; other site 189918002278 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 189918002279 nudix motif; other site 189918002280 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 189918002281 thiamine phosphate binding site [chemical binding]; other site 189918002282 active site 189918002283 pyrophosphate binding site [ion binding]; other site 189918002284 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 189918002285 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 189918002286 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 189918002287 thiS-thiF/thiG interaction site; other site 189918002288 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 189918002289 ThiS interaction site; other site 189918002290 putative active site [active] 189918002291 tetramer interface [polypeptide binding]; other site 189918002292 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 189918002293 active site 189918002294 catalytic triad [active] 189918002295 oxyanion hole [active] 189918002296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189918002297 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 189918002298 Walker A/P-loop; other site 189918002299 ATP binding site [chemical binding]; other site 189918002300 Q-loop/lid; other site 189918002301 ABC transporter signature motif; other site 189918002302 Walker B; other site 189918002303 D-loop; other site 189918002304 H-loop/switch region; other site 189918002305 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 189918002306 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 189918002307 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 189918002308 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 189918002309 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 189918002310 PA/protease or protease-like domain interface [polypeptide binding]; other site 189918002311 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 189918002312 active site 189918002313 metal binding site [ion binding]; metal-binding site 189918002314 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 189918002315 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 189918002316 PA/protease or protease-like domain interface [polypeptide binding]; other site 189918002317 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 189918002318 Peptidase family M28; Region: Peptidase_M28; pfam04389 189918002319 active site 189918002320 metal binding site [ion binding]; metal-binding site 189918002321 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 189918002322 amino acid transporter; Region: 2A0306; TIGR00909 189918002323 amino acid transporter; Region: 2A0306; TIGR00909 189918002324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002328 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918002329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918002330 Septum formation; Region: Septum_form; pfam13845 189918002331 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 189918002332 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 189918002333 dimer interface [polypeptide binding]; other site 189918002334 substrate binding site [chemical binding]; other site 189918002335 ATP binding site [chemical binding]; other site 189918002336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918002337 putative substrate translocation pore; other site 189918002338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918002339 AAA ATPase domain; Region: AAA_16; pfam13191 189918002340 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 189918002341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918002342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918002343 DNA binding residues [nucleotide binding] 189918002344 dimerization interface [polypeptide binding]; other site 189918002345 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 189918002346 putative catalytic site [active] 189918002347 putative phosphate binding site [ion binding]; other site 189918002348 active site 189918002349 metal binding site A [ion binding]; metal-binding site 189918002350 DNA binding site [nucleotide binding] 189918002351 putative AP binding site [nucleotide binding]; other site 189918002352 putative metal binding site B [ion binding]; other site 189918002353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 189918002354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918002355 Coenzyme A binding pocket [chemical binding]; other site 189918002356 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 189918002357 active site 189918002358 catalytic residues [active] 189918002359 metal binding site [ion binding]; metal-binding site 189918002360 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 189918002361 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 189918002362 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 189918002363 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 189918002364 E-class dimer interface [polypeptide binding]; other site 189918002365 P-class dimer interface [polypeptide binding]; other site 189918002366 active site 189918002367 Cu2+ binding site [ion binding]; other site 189918002368 Zn2+ binding site [ion binding]; other site 189918002369 carboxylate-amine ligase; Provisional; Region: PRK13517 189918002370 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 189918002371 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 189918002372 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 189918002373 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918002374 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918002375 Leucine carboxyl methyltransferase; Region: LCM; cl01306 189918002376 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 189918002377 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 189918002378 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 189918002379 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 189918002380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189918002381 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 189918002382 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 189918002383 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 189918002384 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189918002385 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 189918002386 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 189918002387 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 189918002388 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 189918002389 transmembrane helices; other site 189918002390 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 189918002391 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 189918002392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189918002393 Histidine kinase; Region: HisKA_3; pfam07730 189918002394 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 189918002395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918002397 active site 189918002398 phosphorylation site [posttranslational modification] 189918002399 intermolecular recognition site; other site 189918002400 dimerization interface [polypeptide binding]; other site 189918002401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918002402 DNA binding residues [nucleotide binding] 189918002403 dimerization interface [polypeptide binding]; other site 189918002404 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 189918002405 2TM domain; Region: 2TM; pfam13239 189918002406 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 189918002407 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 189918002408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918002409 Walker A motif; other site 189918002410 ATP binding site [chemical binding]; other site 189918002411 Walker B motif; other site 189918002412 arginine finger; other site 189918002413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918002414 Walker A motif; other site 189918002415 ATP binding site [chemical binding]; other site 189918002416 Walker B motif; other site 189918002417 arginine finger; other site 189918002418 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 189918002419 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 189918002420 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 189918002421 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 189918002422 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 189918002423 dimer interface [polypeptide binding]; other site 189918002424 putative functional site; other site 189918002425 putative MPT binding site; other site 189918002426 short chain dehydrogenase; Provisional; Region: PRK06197 189918002427 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 189918002428 putative NAD(P) binding site [chemical binding]; other site 189918002429 active site 189918002430 Uncharacterized conserved protein [Function unknown]; Region: COG3402 189918002431 Predicted membrane protein [Function unknown]; Region: COG3428 189918002432 Bacterial PH domain; Region: DUF304; pfam03703 189918002433 Bacterial PH domain; Region: DUF304; cl01348 189918002434 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 189918002435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918002436 active site 189918002437 motif I; other site 189918002438 motif II; other site 189918002439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918002440 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 189918002441 TrkA-N domain; Region: TrkA_N; pfam02254 189918002442 PAS domain; Region: PAS_9; pfam13426 189918002443 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918002444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918002445 DNA binding residues [nucleotide binding] 189918002446 dimerization interface [polypeptide binding]; other site 189918002447 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 189918002448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918002449 ATP binding site [chemical binding]; other site 189918002450 putative Mg++ binding site [ion binding]; other site 189918002451 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 189918002452 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 189918002453 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189918002454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918002455 ABC transporter signature motif; other site 189918002456 Walker B; other site 189918002457 D-loop; other site 189918002458 H-loop/switch region; other site 189918002459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918002460 Walker A/P-loop; other site 189918002461 ATP binding site [chemical binding]; other site 189918002462 Q-loop/lid; other site 189918002463 ABC transporter signature motif; other site 189918002464 Walker B; other site 189918002465 D-loop; other site 189918002466 H-loop/switch region; other site 189918002467 Cupin domain; Region: Cupin_2; pfam07883 189918002468 short chain dehydrogenase; Provisional; Region: PRK06197 189918002469 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 189918002470 putative NAD(P) binding site [chemical binding]; other site 189918002471 active site 189918002472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002474 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 189918002475 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 189918002476 ring oligomerisation interface [polypeptide binding]; other site 189918002477 ATP/Mg binding site [chemical binding]; other site 189918002478 stacking interactions; other site 189918002479 hinge regions; other site 189918002480 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 189918002481 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918002482 active site 189918002483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918002484 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 189918002485 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918002486 Protein of unknown function (DUF664); Region: DUF664; pfam04978 189918002487 DinB superfamily; Region: DinB_2; pfam12867 189918002488 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918002489 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 189918002490 NAD(P) binding site [chemical binding]; other site 189918002491 catalytic residues [active] 189918002492 enoyl-CoA hydratase; Provisional; Region: PRK12478 189918002493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918002494 substrate binding site [chemical binding]; other site 189918002495 oxyanion hole (OAH) forming residues; other site 189918002496 trimer interface [polypeptide binding]; other site 189918002497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918002498 Cytochrome P450; Region: p450; cl12078 189918002499 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918002500 classical (c) SDRs; Region: SDR_c; cd05233 189918002501 NAD(P) binding site [chemical binding]; other site 189918002502 active site 189918002503 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 189918002504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918002505 Cytochrome P450; Region: p450; cl12078 189918002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002507 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918002508 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918002509 active site 189918002510 Winged helix-turn helix; Region: HTH_29; pfam13551 189918002511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 189918002512 Integrase core domain; Region: rve; pfam00665 189918002513 Integrase core domain; Region: rve_3; pfam13683 189918002514 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 189918002515 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918002516 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918002517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918002518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918002519 acetoin reductases; Region: 23BDH; TIGR02415 189918002520 NAD(P) binding site [chemical binding]; other site 189918002521 active site 189918002522 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 189918002523 GAF domain; Region: GAF; pfam01590 189918002524 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 189918002525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918002526 NAD(P) binding site [chemical binding]; other site 189918002527 catalytic residues [active] 189918002528 Protein of unknown function (DUF779); Region: DUF779; pfam05610 189918002529 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 189918002530 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 189918002531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918002532 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 189918002533 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918002534 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918002535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918002536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918002537 non-specific DNA binding site [nucleotide binding]; other site 189918002538 salt bridge; other site 189918002539 sequence-specific DNA binding site [nucleotide binding]; other site 189918002540 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 189918002541 Domain of unknown function (DUF955); Region: DUF955; pfam06114 189918002542 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 189918002543 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 189918002544 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918002545 active site 2 [active] 189918002546 active site 1 [active] 189918002547 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918002548 isocitrate lyase; Provisional; Region: PRK15063 189918002549 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 189918002550 tetramer interface [polypeptide binding]; other site 189918002551 active site 189918002552 Mg2+/Mn2+ binding site [ion binding]; other site 189918002553 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 189918002554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189918002555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 189918002556 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 189918002557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002559 Predicted membrane protein [Function unknown]; Region: COG2733 189918002560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918002561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918002562 non-specific DNA binding site [nucleotide binding]; other site 189918002563 salt bridge; other site 189918002564 sequence-specific DNA binding site [nucleotide binding]; other site 189918002565 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 189918002566 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 189918002567 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 189918002568 catalytic residue [active] 189918002569 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 189918002570 Predicted amidohydrolase [General function prediction only]; Region: COG0388 189918002571 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 189918002572 putative active site [active] 189918002573 catalytic triad [active] 189918002574 putative dimer interface [polypeptide binding]; other site 189918002575 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 189918002576 Na binding site [ion binding]; other site 189918002577 putative glycosylation site [posttranslational modification]; other site 189918002578 putative glycosylation site [posttranslational modification]; other site 189918002579 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189918002580 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 189918002581 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 189918002582 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 189918002583 FAD binding domain; Region: FAD_binding_4; pfam01565 189918002584 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 189918002585 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 189918002586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918002587 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918002588 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918002589 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 189918002590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918002591 NAD(P) binding site [chemical binding]; other site 189918002592 active site 189918002593 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 189918002594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918002595 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 189918002596 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 189918002597 putative ADP-binding pocket [chemical binding]; other site 189918002598 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 189918002599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918002600 catalytic core [active] 189918002601 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918002602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918002603 dimer interface [polypeptide binding]; other site 189918002604 phosphorylation site [posttranslational modification] 189918002605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918002606 ATP binding site [chemical binding]; other site 189918002607 G-X-G motif; other site 189918002608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918002609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918002610 active site 189918002611 phosphorylation site [posttranslational modification] 189918002612 intermolecular recognition site; other site 189918002613 dimerization interface [polypeptide binding]; other site 189918002614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918002615 DNA binding site [nucleotide binding] 189918002616 YCII-related domain; Region: YCII; cl00999 189918002617 exopolyphosphatase; Region: exo_poly_only; TIGR03706 189918002618 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 189918002619 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 189918002620 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 189918002621 DNA interaction; other site 189918002622 Metal-binding active site; metal-binding site 189918002623 AP (apurinic/apyrimidinic) site pocket; other site 189918002624 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918002625 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 189918002626 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 189918002627 DNA binding domain, excisionase family; Region: excise; TIGR01764 189918002628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918002629 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 189918002630 putative NAD(P) binding site [chemical binding]; other site 189918002631 active site 189918002632 putative substrate binding site [chemical binding]; other site 189918002633 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918002634 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918002635 putative acyl-acceptor binding pocket; other site 189918002636 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918002637 active site 189918002638 catalytic site [active] 189918002639 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 189918002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918002641 motif II; other site 189918002642 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 189918002643 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 189918002644 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 189918002645 tRNA; other site 189918002646 putative tRNA binding site [nucleotide binding]; other site 189918002647 putative NADP binding site [chemical binding]; other site 189918002648 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 189918002649 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 189918002650 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 189918002651 domain interfaces; other site 189918002652 active site 189918002653 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 189918002654 homodimer interface [polypeptide binding]; other site 189918002655 active site 189918002656 SAM binding site [chemical binding]; other site 189918002657 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 189918002658 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 189918002659 active site 189918002660 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 189918002661 dimer interface [polypeptide binding]; other site 189918002662 active site 189918002663 Schiff base residues; other site 189918002664 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918002665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002667 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 189918002668 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 189918002669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918002670 inhibitor-cofactor binding pocket; inhibition site 189918002671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918002672 catalytic residue [active] 189918002673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918002674 catalytic core [active] 189918002675 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189918002676 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918002677 catalytic residues [active] 189918002678 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 189918002679 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 189918002680 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 189918002681 ResB-like family; Region: ResB; pfam05140 189918002682 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 189918002683 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918002684 AAA domain; Region: AAA_31; pfam13614 189918002685 P-loop; other site 189918002686 Magnesium ion binding site [ion binding]; other site 189918002687 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 189918002688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918002689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918002690 catalytic residue [active] 189918002691 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918002692 Homeodomain-like domain; Region: HTH_23; cl17451 189918002693 Clp amino terminal domain; Region: Clp_N; pfam02861 189918002694 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 189918002695 UbiA prenyltransferase family; Region: UbiA; pfam01040 189918002696 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 189918002697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918002698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918002699 NAD(P) binding site [chemical binding]; other site 189918002700 active site 189918002701 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189918002702 Nitronate monooxygenase; Region: NMO; pfam03060 189918002703 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918002704 FMN binding site [chemical binding]; other site 189918002705 substrate binding site [chemical binding]; other site 189918002706 putative catalytic residue [active] 189918002707 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189918002708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918002709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918002710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918002711 dimer interface [polypeptide binding]; other site 189918002712 phosphorylation site [posttranslational modification] 189918002713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918002714 ATP binding site [chemical binding]; other site 189918002715 Mg2+ binding site [ion binding]; other site 189918002716 G-X-G motif; other site 189918002717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918002718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918002719 active site 189918002720 phosphorylation site [posttranslational modification] 189918002721 intermolecular recognition site; other site 189918002722 dimerization interface [polypeptide binding]; other site 189918002723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918002724 DNA binding site [nucleotide binding] 189918002725 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 189918002726 Ligand binding site; other site 189918002727 Putative Catalytic site; other site 189918002728 DXD motif; other site 189918002729 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 189918002730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918002731 S-adenosylmethionine binding site [chemical binding]; other site 189918002732 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 189918002733 Moco binding site; other site 189918002734 metal coordination site [ion binding]; other site 189918002735 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 189918002736 cyanate hydratase; Validated; Region: PRK02866 189918002737 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 189918002738 oligomer interface [polypeptide binding]; other site 189918002739 active site 189918002740 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 189918002741 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 189918002742 putative molybdopterin cofactor binding site [chemical binding]; other site 189918002743 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 189918002744 putative molybdopterin cofactor binding site; other site 189918002745 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918002746 Ligand Binding Site [chemical binding]; other site 189918002747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918002748 Ligand Binding Site [chemical binding]; other site 189918002749 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 189918002750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918002751 dimerization interface [polypeptide binding]; other site 189918002752 putative DNA binding site [nucleotide binding]; other site 189918002753 Predicted transcriptional regulator [Transcription]; Region: COG2345 189918002754 putative Zn2+ binding site [ion binding]; other site 189918002755 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 189918002756 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 189918002757 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 189918002758 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 189918002759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918002760 active site 189918002761 CoA binding site [chemical binding]; other site 189918002762 AMP binding site [chemical binding]; other site 189918002763 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 189918002764 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 189918002765 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 189918002766 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918002767 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918002768 active site 189918002769 short chain dehydrogenase; Provisional; Region: PRK05866 189918002770 classical (c) SDRs; Region: SDR_c; cd05233 189918002771 NAD(P) binding site [chemical binding]; other site 189918002772 active site 189918002773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002775 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918002776 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918002777 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 189918002778 substrate binding site [chemical binding]; other site 189918002779 oxyanion hole (OAH) forming residues; other site 189918002780 trimer interface [polypeptide binding]; other site 189918002781 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 189918002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918002783 motif II; other site 189918002784 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 189918002785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918002786 DNA binding residues [nucleotide binding] 189918002787 acyl-CoA synthetase; Validated; Region: PRK06188 189918002788 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918002789 putative active site [active] 189918002790 putative CoA binding site [chemical binding]; other site 189918002791 putative AMP binding site [chemical binding]; other site 189918002792 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 189918002793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 189918002794 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 189918002795 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 189918002796 active site 189918002797 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918002798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918002799 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918002800 acyl-activating enzyme (AAE) consensus motif; other site 189918002801 acyl-activating enzyme (AAE) consensus motif; other site 189918002802 putative AMP binding site [chemical binding]; other site 189918002803 putative active site [active] 189918002804 putative CoA binding site [chemical binding]; other site 189918002805 O-succinylbenzoate synthase; Provisional; Region: PRK02901 189918002806 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 189918002807 active site 189918002808 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918002809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918002810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918002811 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 189918002812 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 189918002813 conserved cys residue [active] 189918002814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918002815 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 189918002816 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 189918002817 conserved cys residue [active] 189918002818 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 189918002819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918002820 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918002821 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918002822 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 189918002823 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 189918002824 dimer interface [polypeptide binding]; other site 189918002825 tetramer interface [polypeptide binding]; other site 189918002826 PYR/PP interface [polypeptide binding]; other site 189918002827 TPP binding site [chemical binding]; other site 189918002828 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 189918002829 TPP-binding site; other site 189918002830 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 189918002831 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918002832 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 189918002833 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918002834 NAD binding site [chemical binding]; other site 189918002835 catalytic Zn binding site [ion binding]; other site 189918002836 structural Zn binding site [ion binding]; other site 189918002837 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 189918002838 catalytic residues [active] 189918002839 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_3; cd06228 189918002840 putative active site [active] 189918002841 Zn binding site [ion binding]; other site 189918002842 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918002843 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 189918002844 short chain dehydrogenase; Provisional; Region: PRK08263 189918002845 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 189918002846 NADP binding site [chemical binding]; other site 189918002847 active site 189918002848 steroid binding site; other site 189918002849 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 189918002850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918002851 S-adenosylmethionine binding site [chemical binding]; other site 189918002852 Uncharacterized conserved protein [Function unknown]; Region: COG3349 189918002853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918002854 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 189918002855 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 189918002856 putative active site [active] 189918002857 metal binding site [ion binding]; metal-binding site 189918002858 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 189918002859 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 189918002860 Predicted membrane protein [Function unknown]; Region: COG2860 189918002861 UPF0126 domain; Region: UPF0126; pfam03458 189918002862 UPF0126 domain; Region: UPF0126; pfam03458 189918002863 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 189918002864 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 189918002865 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 189918002866 putative active site [active] 189918002867 catalytic site [active] 189918002868 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 189918002869 putative active site [active] 189918002870 catalytic site [active] 189918002871 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 189918002872 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918002873 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 189918002874 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189918002875 substrate binding pocket [chemical binding]; other site 189918002876 chain length determination region; other site 189918002877 substrate-Mg2+ binding site; other site 189918002878 catalytic residues [active] 189918002879 aspartate-rich region 1; other site 189918002880 active site lid residues [active] 189918002881 aspartate-rich region 2; other site 189918002882 heat shock protein HtpX; Provisional; Region: PRK03072 189918002883 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 189918002884 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 189918002885 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 189918002886 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 189918002887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 189918002888 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 189918002889 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 189918002890 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 189918002891 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 189918002892 FOG: PKD repeat [General function prediction only]; Region: COG3291 189918002893 AAA ATPase domain; Region: AAA_16; pfam13191 189918002894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189918002895 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918002896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918002897 DNA binding residues [nucleotide binding] 189918002898 dimerization interface [polypeptide binding]; other site 189918002899 MarR family; Region: MarR_2; pfam12802 189918002900 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918002901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918002902 active site 189918002903 ATP binding site [chemical binding]; other site 189918002904 substrate binding site [chemical binding]; other site 189918002905 activation loop (A-loop); other site 189918002906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918002907 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918002908 substrate binding pocket [chemical binding]; other site 189918002909 membrane-bound complex binding site; other site 189918002910 hinge residues; other site 189918002911 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 189918002912 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 189918002913 dimer interface [polypeptide binding]; other site 189918002914 active site 189918002915 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 189918002916 PEGA domain; Region: PEGA; pfam08308 189918002917 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918002918 Cytochrome P450; Region: p450; cl12078 189918002919 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918002920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918002921 S-adenosylmethionine binding site [chemical binding]; other site 189918002922 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918002924 S-adenosylmethionine binding site [chemical binding]; other site 189918002925 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 189918002926 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 189918002927 putative active site [active] 189918002928 putative ligand binding site [chemical binding]; other site 189918002929 putative NAD(P) binding site [chemical binding]; other site 189918002930 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 189918002931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918002932 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918002933 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918002934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918002935 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918002936 active site 189918002937 ATP binding site [chemical binding]; other site 189918002938 substrate binding site [chemical binding]; other site 189918002939 activation loop (A-loop); other site 189918002940 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918002941 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918002942 cyclase homology domain; Region: CHD; cd07302 189918002943 nucleotidyl binding site; other site 189918002944 metal binding site [ion binding]; metal-binding site 189918002945 dimer interface [polypeptide binding]; other site 189918002946 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 189918002947 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918002948 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 189918002949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918002950 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 189918002951 Part of AAA domain; Region: AAA_19; pfam13245 189918002952 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 189918002953 AAA domain; Region: AAA_12; pfam13087 189918002954 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 189918002955 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 189918002956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918002957 ATP binding site [chemical binding]; other site 189918002958 putative Mg++ binding site [ion binding]; other site 189918002959 helicase superfamily c-terminal domain; Region: HELICc; smart00490 189918002960 ATP-binding site [chemical binding]; other site 189918002961 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 189918002962 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918002963 MULE transposase domain; Region: MULE; pfam10551 189918002964 Uncharacterized conserved protein [Function unknown]; Region: COG1479 189918002965 Protein of unknown function DUF262; Region: DUF262; pfam03235 189918002966 Uncharacterized conserved protein [Function unknown]; Region: COG3472 189918002967 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 189918002968 Family description; Region: UvrD_C_2; pfam13538 189918002969 DEAD-like helicases superfamily; Region: DEXDc; smart00487 189918002970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918002971 ATP binding site [chemical binding]; other site 189918002972 putative Mg++ binding site [ion binding]; other site 189918002973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918002974 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 189918002975 nucleotide binding region [chemical binding]; other site 189918002976 ATP-binding site [chemical binding]; other site 189918002977 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 189918002978 ATP-binding site [chemical binding]; other site 189918002979 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 189918002980 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 189918002981 putative active site [active] 189918002982 putative catalytic site [active] 189918002983 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 189918002984 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 189918002985 cofactor binding site; other site 189918002986 DNA binding site [nucleotide binding] 189918002987 substrate interaction site [chemical binding]; other site 189918002988 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 189918002989 additional DNA contacts [nucleotide binding]; other site 189918002990 mismatch recognition site; other site 189918002991 active site 189918002992 zinc binding site [ion binding]; other site 189918002993 DNA intercalation site [nucleotide binding]; other site 189918002994 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 189918002995 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 189918002996 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 189918002997 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 189918002998 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 189918002999 putative active site [active] 189918003000 Nuclease-related domain; Region: NERD; pfam08378 189918003001 Part of AAA domain; Region: AAA_19; pfam13245 189918003002 Family description; Region: UvrD_C_2; pfam13538 189918003003 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 189918003004 Mrr N-terminal domain; Region: Mrr_N; pfam14338 189918003005 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 189918003006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918003007 Walker A motif; other site 189918003008 ATP binding site [chemical binding]; other site 189918003009 Walker B motif; other site 189918003010 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 189918003011 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 189918003012 active site 189918003013 catalytic residues [active] 189918003014 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 189918003015 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189918003016 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 189918003017 nudix motif; other site 189918003018 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 189918003019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918003022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918003023 NAD(P) binding site [chemical binding]; other site 189918003024 active site 189918003025 Fic/DOC family; Region: Fic; cl00960 189918003026 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 189918003027 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 189918003028 DNA binding site [nucleotide binding] 189918003029 Transposase; Region: HTH_Tnp_1; pfam01527 189918003030 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189918003031 Mechanosensitive ion channel; Region: MS_channel; pfam00924 189918003032 SIR2-like domain; Region: SIR2_2; pfam13289 189918003033 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189918003034 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189918003035 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189918003036 protein binding site [polypeptide binding]; other site 189918003037 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 189918003038 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 189918003039 EamA-like transporter family; Region: EamA; pfam00892 189918003040 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 189918003041 EamA-like transporter family; Region: EamA; pfam00892 189918003042 short chain dehydrogenase; Provisional; Region: PRK05866 189918003043 classical (c) SDRs; Region: SDR_c; cd05233 189918003044 NAD(P) binding site [chemical binding]; other site 189918003045 active site 189918003046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 189918003047 Microsomal signal peptidase 12 kDa subunit (SPC12); Region: SPC12; pfam06645 189918003048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003050 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918003051 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918003052 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189918003053 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 189918003054 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 189918003055 PIF1-like helicase; Region: PIF1; pfam05970 189918003056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918003057 Walker A motif; other site 189918003058 ATP binding site [chemical binding]; other site 189918003059 Walker B motif; other site 189918003060 Family description; Region: UvrD_C_2; pfam13538 189918003061 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 189918003062 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 189918003063 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 189918003065 P-loop containing region of AAA domain; Region: AAA_29; cl17516 189918003066 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 189918003067 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 189918003068 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 189918003069 Creatinine amidohydrolase; Region: Creatininase; pfam02633 189918003070 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 189918003071 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 189918003072 NAD binding site [chemical binding]; other site 189918003073 ligand binding site [chemical binding]; other site 189918003074 catalytic site [active] 189918003075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918003076 dimer interface [polypeptide binding]; other site 189918003077 conserved gate region; other site 189918003078 putative PBP binding loops; other site 189918003079 ABC-ATPase subunit interface; other site 189918003080 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918003081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918003082 Walker A/P-loop; other site 189918003083 ATP binding site [chemical binding]; other site 189918003084 Q-loop/lid; other site 189918003085 ABC transporter signature motif; other site 189918003086 Walker B; other site 189918003087 D-loop; other site 189918003088 H-loop/switch region; other site 189918003089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918003090 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918003091 substrate binding pocket [chemical binding]; other site 189918003092 membrane-bound complex binding site; other site 189918003093 hinge residues; other site 189918003094 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 189918003095 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918003096 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 189918003097 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 189918003098 AsnC family; Region: AsnC_trans_reg; pfam01037 189918003099 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 189918003100 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 189918003101 haloalkane dehalogenase; Provisional; Region: PRK03592 189918003102 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918003103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003107 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918003108 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918003109 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 189918003110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918003111 NAD(P) binding site [chemical binding]; other site 189918003112 active site 189918003113 Uncharacterized conserved protein [Function unknown]; Region: COG1434 189918003114 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 189918003115 putative active site [active] 189918003116 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 189918003117 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918003118 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918003119 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 189918003120 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 189918003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918003122 putative PBP binding loops; other site 189918003123 dimer interface [polypeptide binding]; other site 189918003124 ABC-ATPase subunit interface; other site 189918003125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 189918003126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918003127 dimer interface [polypeptide binding]; other site 189918003128 conserved gate region; other site 189918003129 putative PBP binding loops; other site 189918003130 ABC-ATPase subunit interface; other site 189918003131 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 189918003132 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 189918003133 Walker A/P-loop; other site 189918003134 ATP binding site [chemical binding]; other site 189918003135 Q-loop/lid; other site 189918003136 ABC transporter signature motif; other site 189918003137 Walker B; other site 189918003138 D-loop; other site 189918003139 H-loop/switch region; other site 189918003140 TOBE domain; Region: TOBE_2; pfam08402 189918003141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918003142 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 189918003143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918003144 active site 189918003145 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 189918003146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918003147 active site 189918003148 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 189918003149 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 189918003150 active site 189918003151 dimer interface [polypeptide binding]; other site 189918003152 non-prolyl cis peptide bond; other site 189918003153 insertion regions; other site 189918003154 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 189918003155 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 189918003156 active site 189918003157 non-prolyl cis peptide bond; other site 189918003158 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189918003159 Sulfatase; Region: Sulfatase; cl17466 189918003160 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918003161 hydrophobic ligand binding site; other site 189918003162 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 189918003163 DNA binding residues [nucleotide binding] 189918003164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918003165 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 189918003166 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 189918003167 Sulfate transporter family; Region: Sulfate_transp; pfam00916 189918003168 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 189918003169 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 189918003170 AAA domain; Region: AAA_30; pfam13604 189918003171 Family description; Region: UvrD_C_2; pfam13538 189918003172 LabA_like proteins; Region: LabA_like; cd06167 189918003173 putative metal binding site [ion binding]; other site 189918003174 Uncharacterized conserved protein [Function unknown]; Region: COG1432 189918003175 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 189918003176 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918003177 anti sigma factor interaction site; other site 189918003178 regulatory phosphorylation site [posttranslational modification]; other site 189918003179 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 189918003180 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 189918003181 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 189918003182 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 189918003183 HD domain; Region: HD_4; pfam13328 189918003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918003185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918003186 putative substrate translocation pore; other site 189918003187 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918003188 MarR family; Region: MarR_2; pfam12802 189918003189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918003190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918003191 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 189918003192 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 189918003193 oligomer interface [polypeptide binding]; other site 189918003194 metal binding site [ion binding]; metal-binding site 189918003195 metal binding site [ion binding]; metal-binding site 189918003196 putative Cl binding site [ion binding]; other site 189918003197 aspartate ring; other site 189918003198 basic sphincter; other site 189918003199 hydrophobic gate; other site 189918003200 periplasmic entrance; other site 189918003201 HD domain; Region: HD_5; pfam13487 189918003202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918003203 Zn2+ binding site [ion binding]; other site 189918003204 Mg2+ binding site [ion binding]; other site 189918003205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918003206 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918003207 DNA binding residues [nucleotide binding] 189918003208 dimerization interface [polypeptide binding]; other site 189918003209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003211 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918003212 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918003213 substrate binding site [chemical binding]; other site 189918003214 oxyanion hole (OAH) forming residues; other site 189918003215 trimer interface [polypeptide binding]; other site 189918003216 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 189918003217 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 189918003218 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918003219 Transcriptional regulator; Region: Rrf2; cl17282 189918003220 Predicted transcriptional regulator [Transcription]; Region: COG1959 189918003221 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 189918003222 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 189918003223 heme-binding site [chemical binding]; other site 189918003224 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 189918003225 FAD binding pocket [chemical binding]; other site 189918003226 FAD binding motif [chemical binding]; other site 189918003227 phosphate binding motif [ion binding]; other site 189918003228 beta-alpha-beta structure motif; other site 189918003229 NAD binding pocket [chemical binding]; other site 189918003230 Heme binding pocket [chemical binding]; other site 189918003231 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 189918003232 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918003233 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 189918003234 active site 189918003235 catalytic site [active] 189918003236 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918003237 active site 189918003238 catalytic site [active] 189918003239 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 189918003240 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 189918003241 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 189918003242 putative homodimer interface [polypeptide binding]; other site 189918003243 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 189918003244 heterodimer interface [polypeptide binding]; other site 189918003245 homodimer interface [polypeptide binding]; other site 189918003246 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 189918003247 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 189918003248 23S rRNA interface [nucleotide binding]; other site 189918003249 L7/L12 interface [polypeptide binding]; other site 189918003250 putative thiostrepton binding site; other site 189918003251 L25 interface [polypeptide binding]; other site 189918003252 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 189918003253 mRNA/rRNA interface [nucleotide binding]; other site 189918003254 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 189918003255 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 189918003256 putative catalytic site [active] 189918003257 putative metal binding site [ion binding]; other site 189918003258 putative phosphate binding site [ion binding]; other site 189918003259 Transposase; Region: HTH_Tnp_1; cl17663 189918003260 putative transposase OrfB; Reviewed; Region: PHA02517 189918003261 HTH-like domain; Region: HTH_21; pfam13276 189918003262 Integrase core domain; Region: rve; pfam00665 189918003263 Integrase core domain; Region: rve_3; cl15866 189918003264 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 189918003265 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189918003266 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 189918003267 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 189918003268 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918003269 MULE transposase domain; Region: MULE; pfam10551 189918003270 Low molecular weight phosphatase family; Region: LMWPc; cl00105 189918003271 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 189918003272 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 189918003273 Integrase core domain; Region: rve; pfam00665 189918003274 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918003275 O-Antigen ligase; Region: Wzy_C; cl04850 189918003276 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 189918003277 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 189918003278 trimer interface [polypeptide binding]; other site 189918003279 active site 189918003280 substrate binding site [chemical binding]; other site 189918003281 CoA binding site [chemical binding]; other site 189918003282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918003283 active site 189918003284 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 189918003285 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 189918003286 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 189918003287 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 189918003288 NADP binding site [chemical binding]; other site 189918003289 active site 189918003290 putative substrate binding site [chemical binding]; other site 189918003291 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 189918003292 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 189918003293 NADP-binding site; other site 189918003294 homotetramer interface [polypeptide binding]; other site 189918003295 substrate binding site [chemical binding]; other site 189918003296 homodimer interface [polypeptide binding]; other site 189918003297 active site 189918003298 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 189918003299 Chain length determinant protein; Region: Wzz; pfam02706 189918003300 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 189918003301 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 189918003302 PE-PPE domain; Region: PE-PPE; pfam08237 189918003303 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918003305 S-adenosylmethionine binding site [chemical binding]; other site 189918003306 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918003307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918003308 S-adenosylmethionine binding site [chemical binding]; other site 189918003309 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918003310 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918003311 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189918003312 ABC1 family; Region: ABC1; pfam03109 189918003313 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 189918003314 active site 189918003315 ATP binding site [chemical binding]; other site 189918003316 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918003317 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 189918003318 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918003319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003320 Protein of unknown function (DUF664); Region: DUF664; pfam04978 189918003321 DinB superfamily; Region: DinB_2; pfam12867 189918003322 DinB superfamily; Region: DinB_2; pfam12867 189918003323 Predicted transcriptional regulator [Transcription]; Region: COG2378 189918003324 HTH domain; Region: HTH_11; pfam08279 189918003325 WYL domain; Region: WYL; pfam13280 189918003326 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 189918003327 putative catalytic site [active] 189918003328 putative metal binding site [ion binding]; other site 189918003329 putative phosphate binding site [ion binding]; other site 189918003330 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 189918003331 active site 189918003332 catalytic site [active] 189918003333 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 189918003334 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 189918003335 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 189918003336 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 189918003337 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 189918003338 nucleotide binding site [chemical binding]; other site 189918003339 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 189918003340 23S rRNA interface [nucleotide binding]; other site 189918003341 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 189918003342 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 189918003343 core dimer interface [polypeptide binding]; other site 189918003344 peripheral dimer interface [polypeptide binding]; other site 189918003345 L10 interface [polypeptide binding]; other site 189918003346 L11 interface [polypeptide binding]; other site 189918003347 putative EF-Tu interaction site [polypeptide binding]; other site 189918003348 putative EF-G interaction site [polypeptide binding]; other site 189918003349 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 189918003350 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 189918003351 Walker A/P-loop; other site 189918003352 ATP binding site [chemical binding]; other site 189918003353 Q-loop/lid; other site 189918003354 ABC transporter signature motif; other site 189918003355 Walker B; other site 189918003356 D-loop; other site 189918003357 H-loop/switch region; other site 189918003358 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 189918003359 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 189918003360 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 189918003361 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 189918003362 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 189918003363 RPB10 interaction site [polypeptide binding]; other site 189918003364 RPB1 interaction site [polypeptide binding]; other site 189918003365 RPB11 interaction site [polypeptide binding]; other site 189918003366 RPB3 interaction site [polypeptide binding]; other site 189918003367 RPB12 interaction site [polypeptide binding]; other site 189918003368 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 189918003369 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 189918003370 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 189918003371 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 189918003372 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 189918003373 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 189918003374 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 189918003375 G-loop; other site 189918003376 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 189918003377 DNA binding site [nucleotide binding] 189918003378 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 189918003379 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 189918003380 endonuclease IV; Provisional; Region: PRK01060 189918003381 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 189918003382 AP (apurinic/apyrimidinic) site pocket; other site 189918003383 DNA interaction; other site 189918003384 Metal-binding active site; metal-binding site 189918003385 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 189918003386 active site 189918003387 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 189918003388 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 189918003389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918003390 active site 189918003391 enoyl-CoA hydratase; Provisional; Region: PRK12478 189918003392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918003393 substrate binding site [chemical binding]; other site 189918003394 oxyanion hole (OAH) forming residues; other site 189918003395 trimer interface [polypeptide binding]; other site 189918003396 PaaX-like protein; Region: PaaX; pfam07848 189918003397 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 189918003398 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918003399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918003400 substrate binding site [chemical binding]; other site 189918003401 oxyanion hole (OAH) forming residues; other site 189918003402 trimer interface [polypeptide binding]; other site 189918003403 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 189918003404 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 189918003405 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 189918003406 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 189918003407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003409 WHG domain; Region: WHG; pfam13305 189918003410 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 189918003411 S17 interaction site [polypeptide binding]; other site 189918003412 S8 interaction site; other site 189918003413 16S rRNA interaction site [nucleotide binding]; other site 189918003414 streptomycin interaction site [chemical binding]; other site 189918003415 23S rRNA interaction site [nucleotide binding]; other site 189918003416 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 189918003417 30S ribosomal protein S7; Validated; Region: PRK05302 189918003418 elongation factor G; Reviewed; Region: PRK00007 189918003419 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 189918003420 G1 box; other site 189918003421 putative GEF interaction site [polypeptide binding]; other site 189918003422 GTP/Mg2+ binding site [chemical binding]; other site 189918003423 Switch I region; other site 189918003424 G2 box; other site 189918003425 G3 box; other site 189918003426 Switch II region; other site 189918003427 G4 box; other site 189918003428 G5 box; other site 189918003429 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 189918003430 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 189918003431 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 189918003432 elongation factor Tu; Reviewed; Region: PRK00049 189918003433 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 189918003434 G1 box; other site 189918003435 GEF interaction site [polypeptide binding]; other site 189918003436 GTP/Mg2+ binding site [chemical binding]; other site 189918003437 Switch I region; other site 189918003438 G2 box; other site 189918003439 G3 box; other site 189918003440 Switch II region; other site 189918003441 G4 box; other site 189918003442 G5 box; other site 189918003443 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 189918003444 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 189918003445 Antibiotic Binding Site [chemical binding]; other site 189918003446 Cutinase; Region: Cutinase; pfam01083 189918003447 Short C-terminal domain; Region: SHOCT; pfam09851 189918003448 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003449 Ligand Binding Site [chemical binding]; other site 189918003450 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003451 Ligand Binding Site [chemical binding]; other site 189918003452 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918003453 classical (c) SDRs; Region: SDR_c; cd05233 189918003454 NAD(P) binding site [chemical binding]; other site 189918003455 active site 189918003456 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918003457 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 189918003458 inhibitor-cofactor binding pocket; inhibition site 189918003459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918003460 catalytic residue [active] 189918003461 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 189918003462 Amidinotransferase; Region: Amidinotransf; pfam02274 189918003463 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 189918003464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918003465 putative DNA binding site [nucleotide binding]; other site 189918003466 putative Zn2+ binding site [ion binding]; other site 189918003467 AsnC family; Region: AsnC_trans_reg; pfam01037 189918003468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918003469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918003470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918003471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 189918003472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918003473 putative dimer interface [polypeptide binding]; other site 189918003474 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 189918003475 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 189918003476 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189918003477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918003478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918003479 DNA binding residues [nucleotide binding] 189918003480 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 189918003481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003482 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 189918003483 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 189918003484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918003485 FeS/SAM binding site; other site 189918003486 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 189918003487 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 189918003488 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918003489 phosphate binding site [ion binding]; other site 189918003490 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 189918003491 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 189918003492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918003493 active site 189918003494 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 189918003495 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189918003496 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 189918003497 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 189918003498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918003499 putative substrate translocation pore; other site 189918003500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003502 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918003503 Cytochrome P450; Region: p450; cl12078 189918003504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918003505 Cytochrome P450; Region: p450; cl12078 189918003506 Carboxylesterase family; Region: COesterase; pfam00135 189918003507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918003508 substrate binding pocket [chemical binding]; other site 189918003509 catalytic triad [active] 189918003510 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 189918003511 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 189918003512 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 189918003513 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 189918003514 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 189918003515 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 189918003516 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 189918003517 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 189918003518 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 189918003519 putative translocon binding site; other site 189918003520 protein-rRNA interface [nucleotide binding]; other site 189918003521 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 189918003522 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 189918003523 G-X-X-G motif; other site 189918003524 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 189918003525 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 189918003526 23S rRNA interface [nucleotide binding]; other site 189918003527 5S rRNA interface [nucleotide binding]; other site 189918003528 putative antibiotic binding site [chemical binding]; other site 189918003529 L25 interface [polypeptide binding]; other site 189918003530 L27 interface [polypeptide binding]; other site 189918003531 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 189918003532 putative translocon interaction site; other site 189918003533 23S rRNA interface [nucleotide binding]; other site 189918003534 signal recognition particle (SRP54) interaction site; other site 189918003535 L23 interface [polypeptide binding]; other site 189918003536 trigger factor interaction site; other site 189918003537 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 189918003538 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189918003539 Sulfatase; Region: Sulfatase; pfam00884 189918003540 Uncharacterized conserved protein [Function unknown]; Region: COG1262 189918003541 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 189918003542 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 189918003543 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 189918003544 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 189918003545 RNA binding site [nucleotide binding]; other site 189918003546 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 189918003547 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 189918003548 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 189918003549 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 189918003550 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 189918003551 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 189918003552 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 189918003553 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 189918003554 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 189918003555 5S rRNA interface [nucleotide binding]; other site 189918003556 L27 interface [polypeptide binding]; other site 189918003557 23S rRNA interface [nucleotide binding]; other site 189918003558 L5 interface [polypeptide binding]; other site 189918003559 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 189918003560 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 189918003561 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 189918003562 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 189918003563 23S rRNA binding site [nucleotide binding]; other site 189918003564 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 189918003565 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 189918003566 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 189918003567 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 189918003568 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189918003569 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 189918003570 NADP binding site [chemical binding]; other site 189918003571 active site 189918003572 steroid binding site; other site 189918003573 Cupin; Region: Cupin_6; pfam12852 189918003574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918003575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918003576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918003577 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918003578 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 189918003579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918003580 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 189918003581 tandem repeat interface [polypeptide binding]; other site 189918003582 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 189918003583 oligomer interface [polypeptide binding]; other site 189918003584 active site residues [active] 189918003585 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 189918003586 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 189918003587 tandem repeat interface [polypeptide binding]; other site 189918003588 oligomer interface [polypeptide binding]; other site 189918003589 active site residues [active] 189918003590 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918003591 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 189918003592 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918003593 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 189918003594 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918003595 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 189918003596 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 189918003597 SecY translocase; Region: SecY; pfam00344 189918003598 adenylate kinase; Reviewed; Region: adk; PRK00279 189918003599 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 189918003600 AMP-binding site [chemical binding]; other site 189918003601 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 189918003602 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 189918003603 active site 189918003604 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 189918003605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918003606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918003607 DNA binding residues [nucleotide binding] 189918003608 Putative zinc-finger; Region: zf-HC2; pfam13490 189918003609 MarR family; Region: MarR; pfam01047 189918003610 Homeodomain-like domain; Region: HTH_23; cl17451 189918003611 Winged helix-turn helix; Region: HTH_29; pfam13551 189918003612 Integrase core domain; Region: rve; pfam00665 189918003613 Integrase core domain; Region: rve_3; pfam13683 189918003614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918003615 NmrA-like family; Region: NmrA; pfam05368 189918003616 NAD(P) binding site [chemical binding]; other site 189918003617 active site 189918003618 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918003619 MarR family; Region: MarR_2; pfam12802 189918003620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918003621 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189918003622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189918003623 Histidine kinase; Region: HisKA_3; pfam07730 189918003624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918003625 ATP binding site [chemical binding]; other site 189918003626 Mg2+ binding site [ion binding]; other site 189918003627 G-X-G motif; other site 189918003628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918003629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918003630 active site 189918003631 phosphorylation site [posttranslational modification] 189918003632 intermolecular recognition site; other site 189918003633 dimerization interface [polypeptide binding]; other site 189918003634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918003635 DNA binding residues [nucleotide binding] 189918003636 dimerization interface [polypeptide binding]; other site 189918003637 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189918003638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918003639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918003640 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 189918003641 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 189918003642 malonyl-CoA binding site [chemical binding]; other site 189918003643 dimer interface [polypeptide binding]; other site 189918003644 active site 189918003645 product binding site; other site 189918003646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 189918003647 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 189918003648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918003649 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918003650 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 189918003651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918003652 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 189918003653 substrate binding pocket [chemical binding]; other site 189918003654 FAD binding site [chemical binding]; other site 189918003655 catalytic base [active] 189918003656 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 189918003657 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 189918003658 tetrameric interface [polypeptide binding]; other site 189918003659 NAD binding site [chemical binding]; other site 189918003660 catalytic residues [active] 189918003661 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 189918003662 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 189918003663 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 189918003664 NAD binding site [chemical binding]; other site 189918003665 substrate binding site [chemical binding]; other site 189918003666 homodimer interface [polypeptide binding]; other site 189918003667 active site 189918003668 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 189918003669 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 189918003670 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 189918003671 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 189918003672 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189918003673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189918003674 ligand binding site [chemical binding]; other site 189918003675 flexible hinge region; other site 189918003676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918003677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918003678 ATP binding site [chemical binding]; other site 189918003679 Mg2+ binding site [ion binding]; other site 189918003680 G-X-G motif; other site 189918003681 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 189918003682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918003683 active site 189918003684 phosphorylation site [posttranslational modification] 189918003685 intermolecular recognition site; other site 189918003686 dimerization interface [polypeptide binding]; other site 189918003687 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 189918003688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918003689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918003690 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918003691 hydrophobic ligand binding site; other site 189918003692 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003693 Ligand Binding Site [chemical binding]; other site 189918003694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003695 Ligand Binding Site [chemical binding]; other site 189918003696 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 189918003697 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918003698 catalytic Zn binding site [ion binding]; other site 189918003699 structural Zn binding site [ion binding]; other site 189918003700 NAD(P) binding site [chemical binding]; other site 189918003701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 189918003702 Predicted kinase [General function prediction only]; Region: COG0645 189918003703 AAA domain; Region: AAA_17; pfam13207 189918003704 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918003705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918003706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918003707 active site 189918003708 phosphorylation site [posttranslational modification] 189918003709 intermolecular recognition site; other site 189918003710 dimerization interface [polypeptide binding]; other site 189918003711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918003712 DNA binding residues [nucleotide binding] 189918003713 dimerization interface [polypeptide binding]; other site 189918003714 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918003715 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189918003716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189918003717 Histidine kinase; Region: HisKA_3; pfam07730 189918003718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918003719 ATP binding site [chemical binding]; other site 189918003720 G-X-G motif; other site 189918003721 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918003722 FMN binding site [chemical binding]; other site 189918003723 dimer interface [polypeptide binding]; other site 189918003724 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 189918003725 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918003726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918003727 active site 189918003728 Erythromycin esterase; Region: Erythro_esteras; pfam05139 189918003729 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 189918003730 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 189918003731 putative dimer interface [polypeptide binding]; other site 189918003732 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 189918003733 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 189918003734 ATP cone domain; Region: ATP-cone; pfam03477 189918003735 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 189918003736 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 189918003737 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 189918003738 active site 189918003739 dimer interface [polypeptide binding]; other site 189918003740 effector binding site; other site 189918003741 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003742 Ligand Binding Site [chemical binding]; other site 189918003743 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918003744 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 189918003745 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 189918003746 tetramer interface [polypeptide binding]; other site 189918003747 TPP-binding site [chemical binding]; other site 189918003748 heterodimer interface [polypeptide binding]; other site 189918003749 phosphorylation loop region [posttranslational modification] 189918003750 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 189918003751 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 189918003752 TPP binding site [chemical binding]; other site 189918003753 alpha subunit interface [polypeptide binding]; other site 189918003754 heterodimer interface [polypeptide binding]; other site 189918003755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189918003756 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 189918003757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189918003758 E3 interaction surface; other site 189918003759 lipoyl attachment site [posttranslational modification]; other site 189918003760 e3 binding domain; Region: E3_binding; pfam02817 189918003761 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189918003762 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 189918003763 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 189918003764 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 189918003765 putative NAD(P) binding site [chemical binding]; other site 189918003766 putative substrate binding site [chemical binding]; other site 189918003767 catalytic Zn binding site [ion binding]; other site 189918003768 structural Zn binding site [ion binding]; other site 189918003769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003770 Ligand Binding Site [chemical binding]; other site 189918003771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003772 Ligand Binding Site [chemical binding]; other site 189918003773 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189918003774 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918003775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918003776 Transporter associated domain; Region: CorC_HlyC; smart01091 189918003777 phosphoglycolate phosphatase; Provisional; Region: PRK01158 189918003778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918003779 active site 189918003780 motif I; other site 189918003781 motif II; other site 189918003782 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 189918003783 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 189918003784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918003785 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 189918003786 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918003787 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 189918003788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003789 Ligand Binding Site [chemical binding]; other site 189918003790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003791 Ligand Binding Site [chemical binding]; other site 189918003792 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 189918003793 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 189918003794 Divalent cation transporter; Region: MgtE; cl00786 189918003795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003796 Ligand Binding Site [chemical binding]; other site 189918003797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003798 Ligand Binding Site [chemical binding]; other site 189918003799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003800 Ligand Binding Site [chemical binding]; other site 189918003801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189918003802 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189918003803 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918003804 dimer interface [polypeptide binding]; other site 189918003805 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 189918003806 rRNA binding site [nucleotide binding]; other site 189918003807 predicted 30S ribosome binding site; other site 189918003808 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 189918003809 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 189918003810 30S ribosomal protein S13; Region: bact_S13; TIGR03631 189918003811 30S ribosomal protein S11; Validated; Region: PRK05309 189918003812 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 189918003813 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 189918003814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189918003815 RNA binding surface [nucleotide binding]; other site 189918003816 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 189918003817 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 189918003818 alphaNTD homodimer interface [polypeptide binding]; other site 189918003819 alphaNTD - beta interaction site [polypeptide binding]; other site 189918003820 alphaNTD - beta' interaction site [polypeptide binding]; other site 189918003821 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 189918003822 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 189918003823 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 189918003824 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 189918003825 dimerization interface 3.5A [polypeptide binding]; other site 189918003826 active site 189918003827 Cutinase; Region: Cutinase; pfam01083 189918003828 Cutinase; Region: Cutinase; pfam01083 189918003829 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 189918003830 EamA-like transporter family; Region: EamA; pfam00892 189918003831 EamA-like transporter family; Region: EamA; pfam00892 189918003832 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 189918003833 CGNR zinc finger; Region: zf-CGNR; pfam11706 189918003834 Homeodomain-like domain; Region: HTH_23; cl17451 189918003835 Winged helix-turn helix; Region: HTH_29; pfam13551 189918003836 Integrase core domain; Region: rve; pfam00665 189918003837 Integrase core domain; Region: rve_3; pfam13683 189918003838 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918003839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918003840 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918003841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918003842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918003843 metal binding site [ion binding]; metal-binding site 189918003844 active site 189918003845 I-site; other site 189918003846 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 189918003847 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 189918003848 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 189918003849 active site 189918003850 catalytic residues [active] 189918003851 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 189918003852 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 189918003853 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918003854 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 189918003855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918003856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918003857 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 189918003858 Proteins of 100 residues with WXG; Region: WXG100; cl02005 189918003859 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 189918003860 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 189918003861 23S rRNA interface [nucleotide binding]; other site 189918003862 L3 interface [polypeptide binding]; other site 189918003863 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 189918003864 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 189918003865 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 189918003866 active site 189918003867 substrate binding site [chemical binding]; other site 189918003868 metal binding site [ion binding]; metal-binding site 189918003869 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 189918003870 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918003871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189918003872 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 189918003873 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 189918003874 glutaminase active site [active] 189918003875 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 189918003876 dimer interface [polypeptide binding]; other site 189918003877 active site 189918003878 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 189918003879 dimer interface [polypeptide binding]; other site 189918003880 active site 189918003881 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 189918003882 putative hydrophobic ligand binding site [chemical binding]; other site 189918003883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918003884 putative DNA binding site [nucleotide binding]; other site 189918003885 dimerization interface [polypeptide binding]; other site 189918003886 putative Zn2+ binding site [ion binding]; other site 189918003887 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 189918003888 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918003889 Uncharacterized conserved protein [Function unknown]; Region: COG0062 189918003890 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 189918003891 putative substrate binding site [chemical binding]; other site 189918003892 putative ATP binding site [chemical binding]; other site 189918003893 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 189918003894 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 189918003895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918003896 catalytic residue [active] 189918003897 alanine racemase; Reviewed; Region: alr; PRK00053 189918003898 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 189918003899 active site 189918003900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189918003901 dimer interface [polypeptide binding]; other site 189918003902 substrate binding site [chemical binding]; other site 189918003903 catalytic residues [active] 189918003904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918003905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918003906 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918003907 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 189918003908 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 189918003909 Glycoprotease family; Region: Peptidase_M22; pfam00814 189918003910 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 189918003911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918003912 Coenzyme A binding pocket [chemical binding]; other site 189918003913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189918003914 UGMP family protein; Validated; Region: PRK09604 189918003915 SnoaL-like domain; Region: SnoaL_4; pfam13577 189918003916 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 189918003917 oligomerisation interface [polypeptide binding]; other site 189918003918 mobile loop; other site 189918003919 roof hairpin; other site 189918003920 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 189918003921 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 189918003922 ring oligomerisation interface [polypeptide binding]; other site 189918003923 ATP/Mg binding site [chemical binding]; other site 189918003924 stacking interactions; other site 189918003925 hinge regions; other site 189918003926 MarR family; Region: MarR_2; cl17246 189918003927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918003928 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 189918003929 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 189918003930 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 189918003931 Transcription factor WhiB; Region: Whib; pfam02467 189918003932 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 189918003933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918003934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918003935 DNA binding residues [nucleotide binding] 189918003936 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 189918003937 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918003938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 189918003939 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 189918003940 active site 189918003941 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 189918003942 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918003943 phosphate binding site [ion binding]; other site 189918003944 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 189918003945 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189918003946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918003947 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189918003948 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 189918003949 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 189918003950 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 189918003951 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 189918003952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918003953 motif II; other site 189918003954 GMP synthase; Reviewed; Region: guaA; PRK00074 189918003955 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 189918003956 AMP/PPi binding site [chemical binding]; other site 189918003957 candidate oxyanion hole; other site 189918003958 catalytic triad [active] 189918003959 potential glutamine specificity residues [chemical binding]; other site 189918003960 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 189918003961 ATP Binding subdomain [chemical binding]; other site 189918003962 Ligand Binding sites [chemical binding]; other site 189918003963 Dimerization subdomain; other site 189918003964 DNA Polymerase Y-family; Region: PolY_like; cd03468 189918003965 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 189918003966 DNA binding site [nucleotide binding] 189918003967 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918003968 MarR family; Region: MarR; pfam01047 189918003969 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 189918003970 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 189918003971 active site 189918003972 MarR family; Region: MarR_2; pfam12802 189918003973 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918003974 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 189918003975 dimer interaction site [polypeptide binding]; other site 189918003976 substrate-binding tunnel; other site 189918003977 active site 189918003978 catalytic site [active] 189918003979 substrate binding site [chemical binding]; other site 189918003980 Universal stress protein family; Region: Usp; pfam00582 189918003981 Ligand Binding Site [chemical binding]; other site 189918003982 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918003983 Ligand Binding Site [chemical binding]; other site 189918003984 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 189918003985 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 189918003986 active site 189918003987 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 189918003988 generic binding surface II; other site 189918003989 generic binding surface I; other site 189918003990 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 189918003991 FMN binding site [chemical binding]; other site 189918003992 dimer interface [polypeptide binding]; other site 189918003993 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 189918003994 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 189918003995 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918003996 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918003997 active site 189918003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918003999 S-adenosylmethionine binding site [chemical binding]; other site 189918004000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918004002 ATP binding site [chemical binding]; other site 189918004003 Mg2+ binding site [ion binding]; other site 189918004004 G-X-G motif; other site 189918004005 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 189918004006 Protein of unknown function (DUF742); Region: DUF742; pfam05331 189918004007 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 189918004008 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 189918004009 G1 box; other site 189918004010 GTP/Mg2+ binding site [chemical binding]; other site 189918004011 G2 box; other site 189918004012 Switch I region; other site 189918004013 G3 box; other site 189918004014 Switch II region; other site 189918004015 G4 box; other site 189918004016 G5 box; other site 189918004017 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 189918004018 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 189918004019 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 189918004020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 189918004021 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 189918004022 Transglutaminase/protease-like homologues; Region: TGc; smart00460 189918004023 PGAP1-like protein; Region: PGAP1; pfam07819 189918004024 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918004025 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918004026 phosphopeptide binding site; other site 189918004027 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918004028 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918004029 phosphopeptide binding site; other site 189918004030 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918004031 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 189918004032 Walker A/P-loop; other site 189918004033 ATP binding site [chemical binding]; other site 189918004034 Q-loop/lid; other site 189918004035 ABC transporter signature motif; other site 189918004036 Walker B; other site 189918004037 D-loop; other site 189918004038 H-loop/switch region; other site 189918004039 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189918004040 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 189918004041 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 189918004042 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 189918004043 active site 189918004044 FMN binding site [chemical binding]; other site 189918004045 substrate binding site [chemical binding]; other site 189918004046 putative catalytic residue [active] 189918004047 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 189918004048 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 189918004049 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 189918004050 homodimer interface [polypeptide binding]; other site 189918004051 NADP binding site [chemical binding]; other site 189918004052 substrate binding site [chemical binding]; other site 189918004053 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 189918004054 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189918004055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918004056 S-adenosylmethionine binding site [chemical binding]; other site 189918004057 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 189918004058 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 189918004059 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 189918004060 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 189918004061 homodimer interface [polypeptide binding]; other site 189918004062 substrate-cofactor binding pocket; other site 189918004063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918004064 catalytic residue [active] 189918004065 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 189918004066 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 189918004067 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918004068 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 189918004069 putative catalytic site [active] 189918004070 putative metal binding site [ion binding]; other site 189918004071 putative phosphate binding site [ion binding]; other site 189918004072 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 189918004073 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 189918004074 active site 189918004075 HIGH motif; other site 189918004076 dimer interface [polypeptide binding]; other site 189918004077 KMSKS motif; other site 189918004078 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 189918004079 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 189918004080 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 189918004081 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918004082 FMN binding site [chemical binding]; other site 189918004083 substrate binding site [chemical binding]; other site 189918004084 putative catalytic residue [active] 189918004085 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 189918004086 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 189918004087 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 189918004088 Strictosidine synthase; Region: Str_synth; pfam03088 189918004089 hypothetical protein; Provisional; Region: PRK06541 189918004090 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918004091 inhibitor-cofactor binding pocket; inhibition site 189918004092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918004093 catalytic residue [active] 189918004094 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 189918004095 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 189918004096 putative DNA binding site [nucleotide binding]; other site 189918004097 putative Zn2+ binding site [ion binding]; other site 189918004098 AsnC family; Region: AsnC_trans_reg; pfam01037 189918004099 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 189918004100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918004101 NAD(P) binding site [chemical binding]; other site 189918004102 catalytic residues [active] 189918004103 Acyltransferase family; Region: Acyl_transf_3; pfam01757 189918004104 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 189918004105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918004106 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 189918004107 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 189918004108 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 189918004109 Domain of unknown function DUF20; Region: UPF0118; pfam01594 189918004110 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 189918004111 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 189918004112 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 189918004113 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 189918004114 L-aspartate oxidase; Provisional; Region: PRK06175 189918004115 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918004116 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 189918004117 putative Iron-sulfur protein interface [polypeptide binding]; other site 189918004118 putative proximal heme binding site [chemical binding]; other site 189918004119 putative SdhC-like subunit interface [polypeptide binding]; other site 189918004120 putative distal heme binding site [chemical binding]; other site 189918004121 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 189918004122 putative Iron-sulfur protein interface [polypeptide binding]; other site 189918004123 putative proximal heme binding site [chemical binding]; other site 189918004124 putative SdhD-like interface [polypeptide binding]; other site 189918004125 putative distal heme binding site [chemical binding]; other site 189918004126 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 189918004127 active site 189918004128 catalytic motif [active] 189918004129 Zn binding site [ion binding]; other site 189918004130 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 189918004131 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 189918004132 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 189918004133 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 189918004134 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 189918004135 adenosine deaminase; Provisional; Region: PRK09358 189918004136 active site 189918004137 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 189918004138 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 189918004139 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918004140 cyclase homology domain; Region: CHD; cd07302 189918004141 nucleotidyl binding site; other site 189918004142 metal binding site [ion binding]; metal-binding site 189918004143 dimer interface [polypeptide binding]; other site 189918004144 cyclase homology domain; Region: CHD; cd07302 189918004145 nucleotidyl binding site; other site 189918004146 metal binding site [ion binding]; metal-binding site 189918004147 dimer interface [polypeptide binding]; other site 189918004148 AAA ATPase domain; Region: AAA_16; pfam13191 189918004149 Double zinc ribbon; Region: DZR; pfam12773 189918004150 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 189918004151 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918004152 cyclase homology domain; Region: CHD; cd07302 189918004153 nucleotidyl binding site; other site 189918004154 metal binding site [ion binding]; metal-binding site 189918004155 dimer interface [polypeptide binding]; other site 189918004156 AAA ATPase domain; Region: AAA_16; pfam13191 189918004157 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918004158 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918004159 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918004160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918004161 active site 189918004162 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 189918004163 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 189918004164 active site 189918004165 substrate binding site [chemical binding]; other site 189918004166 metal binding site [ion binding]; metal-binding site 189918004167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918004168 MarR family; Region: MarR_2; pfam12802 189918004169 Putative ammonia monooxygenase; Region: AmoA; pfam05145 189918004170 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 189918004171 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 189918004172 purine nucleoside phosphorylase; Provisional; Region: PRK08202 189918004173 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 189918004174 amidohydrolase; Region: amidohydrolases; TIGR01891 189918004175 metal binding site [ion binding]; metal-binding site 189918004176 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 189918004177 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 189918004178 metal binding site [ion binding]; metal-binding site 189918004179 putative dimer interface [polypeptide binding]; other site 189918004180 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 189918004181 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 189918004182 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 189918004183 putative active site pocket [active] 189918004184 dimerization interface [polypeptide binding]; other site 189918004185 putative catalytic residue [active] 189918004186 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 189918004187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918004188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918004189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 189918004190 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 189918004191 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 189918004192 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 189918004193 active site 189918004194 short chain dehydrogenase; Provisional; Region: PRK07035 189918004195 classical (c) SDRs; Region: SDR_c; cd05233 189918004196 NAD(P) binding site [chemical binding]; other site 189918004197 active site 189918004198 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918004199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918004200 substrate binding site [chemical binding]; other site 189918004201 oxyanion hole (OAH) forming residues; other site 189918004202 trimer interface [polypeptide binding]; other site 189918004203 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 189918004204 Winged helix-turn helix; Region: HTH_29; pfam13551 189918004205 Integrase core domain; Region: rve; pfam00665 189918004206 Integrase core domain; Region: rve_3; pfam13683 189918004207 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 189918004208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004209 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 189918004210 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918004211 FAD binding pocket [chemical binding]; other site 189918004212 FAD binding motif [chemical binding]; other site 189918004213 phosphate binding motif [ion binding]; other site 189918004214 beta-alpha-beta structure motif; other site 189918004215 NAD binding pocket [chemical binding]; other site 189918004216 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918004217 catalytic loop [active] 189918004218 iron binding site [ion binding]; other site 189918004219 Fatty acid desaturase; Region: FA_desaturase; pfam00487 189918004220 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 189918004221 putative di-iron ligands [ion binding]; other site 189918004222 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 189918004223 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 189918004224 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 189918004225 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 189918004226 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 189918004227 [4Fe-4S] binding site [ion binding]; other site 189918004228 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918004229 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918004230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918004231 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 189918004232 molybdopterin cofactor binding site; other site 189918004233 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 189918004234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918004235 putative substrate translocation pore; other site 189918004236 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 189918004237 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 189918004238 putative DNA binding site [nucleotide binding]; other site 189918004239 catalytic residue [active] 189918004240 putative H2TH interface [polypeptide binding]; other site 189918004241 putative catalytic residues [active] 189918004242 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 189918004243 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 189918004244 Protein of unknown function (DUF1269); Region: DUF1269; pfam06897 189918004245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918004246 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 189918004247 ATP binding site [chemical binding]; other site 189918004248 putative Mg++ binding site [ion binding]; other site 189918004249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918004250 nucleotide binding region [chemical binding]; other site 189918004251 ATP-binding site [chemical binding]; other site 189918004252 DEAD/H associated; Region: DEAD_assoc; pfam08494 189918004253 hypothetical protein; Provisional; Region: PRK06194 189918004254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918004255 NAD(P) binding site [chemical binding]; other site 189918004256 active site 189918004257 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 189918004258 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 189918004259 active site 189918004260 TDP-binding site; other site 189918004261 acceptor substrate-binding pocket; other site 189918004262 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 189918004263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918004264 tetrameric interface [polypeptide binding]; other site 189918004265 NAD binding site [chemical binding]; other site 189918004266 catalytic residues [active] 189918004267 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 189918004268 AsnC family; Region: AsnC_trans_reg; pfam01037 189918004269 L-lysine aminotransferase; Provisional; Region: PRK08297 189918004270 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918004271 inhibitor-cofactor binding pocket; inhibition site 189918004272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918004273 catalytic residue [active] 189918004274 Restriction endonuclease; Region: Mrr_cat; pfam04471 189918004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918004276 short chain dehydrogenase; Provisional; Region: PRK06701 189918004277 NAD(P) binding site [chemical binding]; other site 189918004278 active site 189918004279 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 189918004280 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 189918004281 putative ADP-binding pocket [chemical binding]; other site 189918004282 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 189918004283 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 189918004284 active site 189918004285 DNA binding site [nucleotide binding] 189918004286 Int/Topo IB signature motif; other site 189918004287 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 189918004288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 189918004289 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 189918004290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918004291 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189918004292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918004293 DNA binding residues [nucleotide binding] 189918004294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918004295 anti sigma factor interaction site; other site 189918004296 regulatory phosphorylation site [posttranslational modification]; other site 189918004297 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 189918004298 Ligand binding site; other site 189918004299 metal-binding site 189918004300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918004301 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918004302 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 189918004303 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 189918004304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918004305 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 189918004306 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 189918004307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918004308 carboxyltransferase (CT) interaction site; other site 189918004309 biotinylation site [posttranslational modification]; other site 189918004310 Fe-S metabolism associated domain; Region: SufE; cl00951 189918004311 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 189918004312 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 189918004313 active site residue [active] 189918004314 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 189918004315 active site residue [active] 189918004316 Maf-like protein; Region: Maf; pfam02545 189918004317 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 189918004318 active site 189918004319 dimer interface [polypeptide binding]; other site 189918004320 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 189918004321 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918004322 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918004323 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918004324 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 189918004325 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 189918004326 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189918004327 Bacterial PH domain; Region: DUF304; pfam03703 189918004328 Predicted membrane protein [Function unknown]; Region: COG2246 189918004329 GtrA-like protein; Region: GtrA; pfam04138 189918004330 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 189918004331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918004332 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 189918004333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918004334 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 189918004335 FAD binding site [chemical binding]; other site 189918004336 homotetramer interface [polypeptide binding]; other site 189918004337 substrate binding pocket [chemical binding]; other site 189918004338 catalytic base [active] 189918004339 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 189918004340 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189918004341 hypothetical protein; Provisional; Region: PRK07233 189918004342 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 189918004343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918004344 active site 189918004345 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 189918004346 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 189918004347 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 189918004348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918004349 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 189918004350 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189918004351 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918004352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 189918004353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918004354 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 189918004355 putative active site [active] 189918004356 putative catalytic site [active] 189918004357 putative Zn binding site [ion binding]; other site 189918004358 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 189918004359 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 189918004360 active site 189918004361 homodimer interface [polypeptide binding]; other site 189918004362 TIGR03089 family protein; Region: TIGR03089 189918004363 Transcriptional regulator [Transcription]; Region: LytR; COG1316 189918004364 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 189918004365 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 189918004366 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 189918004367 NADP binding site [chemical binding]; other site 189918004368 active site 189918004369 putative substrate binding site [chemical binding]; other site 189918004370 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 189918004371 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 189918004372 Probable Catalytic site; other site 189918004373 metal-binding site 189918004374 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 189918004375 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 189918004376 active site 189918004377 Substrate binding site; other site 189918004378 Mg++ binding site; other site 189918004379 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 189918004380 putative trimer interface [polypeptide binding]; other site 189918004381 putative CoA binding site [chemical binding]; other site 189918004382 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 189918004383 nudix motif; other site 189918004384 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 189918004385 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 189918004386 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 189918004387 putative FMN binding site [chemical binding]; other site 189918004388 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 189918004389 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 189918004390 phosphate binding site [ion binding]; other site 189918004391 dimer interface [polypeptide binding]; other site 189918004392 Transcription factor WhiB; Region: Whib; pfam02467 189918004393 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 189918004394 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 189918004395 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 189918004396 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 189918004397 active site 189918004398 substrate binding site [chemical binding]; other site 189918004399 metal binding site [ion binding]; metal-binding site 189918004400 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 189918004401 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 189918004402 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 189918004403 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 189918004404 amino acid transporter; Region: 2A0306; TIGR00909 189918004405 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 189918004406 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 189918004407 Fatty acid desaturase; Region: FA_desaturase; pfam00487 189918004408 Di-iron ligands [ion binding]; other site 189918004409 Rubredoxin [Energy production and conversion]; Region: COG1773 189918004410 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 189918004411 iron binding site [ion binding]; other site 189918004412 Rubredoxin [Energy production and conversion]; Region: COG1773 189918004413 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 189918004414 iron binding site [ion binding]; other site 189918004415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004417 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 189918004418 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 189918004419 homotetramer interface [polypeptide binding]; other site 189918004420 ligand binding site [chemical binding]; other site 189918004421 catalytic site [active] 189918004422 NAD binding site [chemical binding]; other site 189918004423 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 189918004424 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 189918004425 metal binding site [ion binding]; metal-binding site 189918004426 putative dimer interface [polypeptide binding]; other site 189918004427 Secretory lipase; Region: LIP; pfam03583 189918004428 ANTAR domain; Region: ANTAR; cl04297 189918004429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189918004430 TPR motif; other site 189918004431 binding surface 189918004432 TPR repeat; Region: TPR_11; pfam13414 189918004433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189918004434 TPR motif; other site 189918004435 binding surface 189918004436 TPR repeat; Region: TPR_11; pfam13414 189918004437 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 189918004438 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 189918004439 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 189918004440 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 189918004441 TMP-binding site; other site 189918004442 ATP-binding site [chemical binding]; other site 189918004443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918004444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918004445 active site 189918004446 phosphorylation site [posttranslational modification] 189918004447 intermolecular recognition site; other site 189918004448 dimerization interface [polypeptide binding]; other site 189918004449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918004450 DNA binding site [nucleotide binding] 189918004451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918004452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918004453 dimerization interface [polypeptide binding]; other site 189918004454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918004455 dimer interface [polypeptide binding]; other site 189918004456 phosphorylation site [posttranslational modification] 189918004457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918004458 ATP binding site [chemical binding]; other site 189918004459 Mg2+ binding site [ion binding]; other site 189918004460 G-X-G motif; other site 189918004461 lipoprotein LpqB; Provisional; Region: PRK13616 189918004462 Sporulation and spore germination; Region: Germane; pfam10646 189918004463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 189918004464 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 189918004465 comF family protein; Region: comF; TIGR00201 189918004466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918004467 active site 189918004468 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 189918004469 30S subunit binding site; other site 189918004470 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 189918004471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 189918004472 ATP binding site [chemical binding]; other site 189918004473 putative Mg++ binding site [ion binding]; other site 189918004474 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 189918004475 RNA12 protein; Region: RNA12; pfam10443 189918004476 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918004477 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918004478 BCCT family transporter; Region: BCCT; pfam02028 189918004479 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 189918004480 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918004481 FAD binding pocket [chemical binding]; other site 189918004482 FAD binding motif [chemical binding]; other site 189918004483 phosphate binding motif [ion binding]; other site 189918004484 beta-alpha-beta structure motif; other site 189918004485 NAD binding pocket [chemical binding]; other site 189918004486 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 189918004487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918004488 catalytic loop [active] 189918004489 iron binding site [ion binding]; other site 189918004490 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 189918004491 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 189918004492 putative di-iron ligands [ion binding]; other site 189918004493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918004494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918004495 active site 189918004496 catalytic tetrad [active] 189918004497 Predicted GTPases [General function prediction only]; Region: COG1162 189918004498 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 189918004499 GTPase/Zn-binding domain interface [polypeptide binding]; other site 189918004500 GTP/Mg2+ binding site [chemical binding]; other site 189918004501 G4 box; other site 189918004502 G5 box; other site 189918004503 G1 box; other site 189918004504 Switch I region; other site 189918004505 G2 box; other site 189918004506 G3 box; other site 189918004507 Switch II region; other site 189918004508 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 189918004509 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 189918004510 hinge; other site 189918004511 active site 189918004512 Uncharacterized conserved protein [Function unknown]; Region: COG2135 189918004513 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 189918004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918004515 S-adenosylmethionine binding site [chemical binding]; other site 189918004516 short chain dehydrogenase; Provisional; Region: PRK08278 189918004517 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 189918004518 NAD(P) binding site [chemical binding]; other site 189918004519 homodimer interface [polypeptide binding]; other site 189918004520 active site 189918004521 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 189918004522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918004523 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 189918004524 dimerization interface [polypeptide binding]; other site 189918004525 substrate binding pocket [chemical binding]; other site 189918004526 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 189918004527 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918004528 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918004529 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 189918004530 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 189918004531 AAA ATPase domain; Region: AAA_16; pfam13191 189918004532 AAA domain; Region: AAA_22; pfam13401 189918004533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918004534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918004535 DNA binding residues [nucleotide binding] 189918004536 dimerization interface [polypeptide binding]; other site 189918004537 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 189918004538 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918004539 catalytic loop [active] 189918004540 iron binding site [ion binding]; other site 189918004541 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 189918004542 FAD binding pocket [chemical binding]; other site 189918004543 FAD binding motif [chemical binding]; other site 189918004544 phosphate binding motif [ion binding]; other site 189918004545 beta-alpha-beta structure motif; other site 189918004546 NAD binding pocket [chemical binding]; other site 189918004547 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 189918004548 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 189918004549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918004550 NAD(P) binding site [chemical binding]; other site 189918004551 active site 189918004552 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918004553 inter-subunit interface; other site 189918004554 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 189918004555 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918004556 iron-sulfur cluster [ion binding]; other site 189918004557 [2Fe-2S] cluster binding site [ion binding]; other site 189918004558 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 189918004559 putative alpha subunit interface [polypeptide binding]; other site 189918004560 putative active site [active] 189918004561 putative substrate binding site [chemical binding]; other site 189918004562 Fe binding site [ion binding]; other site 189918004563 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 189918004564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918004565 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 189918004566 dimerization interface [polypeptide binding]; other site 189918004567 substrate binding pocket [chemical binding]; other site 189918004568 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 189918004569 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 189918004570 active site 189918004571 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 189918004572 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918004573 active site 189918004574 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 189918004575 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 189918004576 putative deacylase active site [active] 189918004577 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 189918004578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918004579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918004580 DNA binding residues [nucleotide binding] 189918004581 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 189918004582 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918004583 carboxyltransferase (CT) interaction site; other site 189918004584 biotinylation site [posttranslational modification]; other site 189918004585 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 189918004586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189918004587 Histidine kinase; Region: HisKA_2; pfam07568 189918004588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918004589 ATP binding site [chemical binding]; other site 189918004590 Mg2+ binding site [ion binding]; other site 189918004591 G-X-G motif; other site 189918004592 Transcription factor WhiB; Region: Whib; pfam02467 189918004593 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 189918004594 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 189918004595 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 189918004596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918004597 Coenzyme A binding pocket [chemical binding]; other site 189918004598 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 189918004599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918004600 catalytic core [active] 189918004601 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918004602 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918004603 P-loop; other site 189918004604 Magnesium ion binding site [ion binding]; other site 189918004605 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 189918004606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918004607 Magnesium ion binding site [ion binding]; other site 189918004608 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 189918004609 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918004610 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 189918004611 putative NAD(P) binding site [chemical binding]; other site 189918004612 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 189918004613 DEAD-like helicases superfamily; Region: DEXDc; smart00487 189918004614 ATP binding site [chemical binding]; other site 189918004615 Mg++ binding site [ion binding]; other site 189918004616 motif III; other site 189918004617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918004618 nucleotide binding region [chemical binding]; other site 189918004619 ATP-binding site [chemical binding]; other site 189918004620 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 189918004621 dinuclear metal binding motif [ion binding]; other site 189918004622 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 189918004623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004625 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 189918004626 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 189918004627 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 189918004628 ATP binding site [chemical binding]; other site 189918004629 substrate interface [chemical binding]; other site 189918004630 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918004631 active site residue [active] 189918004632 TIGR02569 family protein; Region: TIGR02569_actnb 189918004633 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 189918004634 active site 189918004635 DNA binding site [nucleotide binding] 189918004636 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918004637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918004638 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 189918004639 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 189918004640 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 189918004641 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 189918004642 Predicted membrane protein [Function unknown]; Region: COG4270 189918004643 Ion channel; Region: Ion_trans_2; pfam07885 189918004644 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 189918004645 TrkA-N domain; Region: TrkA_N; pfam02254 189918004646 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 189918004647 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 189918004648 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 189918004649 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 189918004650 putative NADH binding site [chemical binding]; other site 189918004651 putative active site [active] 189918004652 nudix motif; other site 189918004653 putative metal binding site [ion binding]; other site 189918004654 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 189918004655 catalytic residues [active] 189918004656 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 189918004657 Family description; Region: UvrD_C_2; pfam13538 189918004658 HRDC domain; Region: HRDC; pfam00570 189918004659 Transcription factor WhiB; Region: Whib; pfam02467 189918004660 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189918004661 ABC1 family; Region: ABC1; pfam03109 189918004662 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 189918004663 active site 189918004664 ATP binding site [chemical binding]; other site 189918004665 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 189918004666 Uncharacterized conserved protein [Function unknown]; Region: COG5282 189918004667 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 189918004668 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 189918004669 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189918004670 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 189918004671 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 189918004672 hypothetical protein; Validated; Region: PRK00068 189918004673 DNA binding site [nucleotide binding] 189918004674 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 189918004675 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 189918004676 Predicted ATPase [General function prediction only]; Region: COG3899 189918004677 AAA ATPase domain; Region: AAA_16; pfam13191 189918004678 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189918004679 FAD binding domain; Region: FAD_binding_4; pfam01565 189918004680 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918004681 MULE transposase domain; Region: MULE; pfam10551 189918004682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918004683 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 189918004684 Int/Topo IB signature motif; other site 189918004685 Helix-turn-helix domain; Region: HTH_36; pfam13730 189918004686 TrwC relaxase; Region: TrwC; pfam08751 189918004687 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 189918004688 AAA domain; Region: AAA_30; pfam13604 189918004689 Family description; Region: UvrD_C_2; pfam13538 189918004690 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189918004691 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189918004692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918004693 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918004694 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918004695 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918004696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918004697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918004698 dimerization interface [polypeptide binding]; other site 189918004699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918004700 dimer interface [polypeptide binding]; other site 189918004701 phosphorylation site [posttranslational modification] 189918004702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918004703 ATP binding site [chemical binding]; other site 189918004704 Mg2+ binding site [ion binding]; other site 189918004705 G-X-G motif; other site 189918004706 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918004707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918004708 active site 189918004709 phosphorylation site [posttranslational modification] 189918004710 intermolecular recognition site; other site 189918004711 dimerization interface [polypeptide binding]; other site 189918004712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918004713 DNA binding site [nucleotide binding] 189918004714 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918004715 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918004716 Penicillinase repressor; Region: Pencillinase_R; cl17580 189918004717 Peptidase family M48; Region: Peptidase_M48; cl12018 189918004718 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 189918004719 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189918004720 dimer interface [polypeptide binding]; other site 189918004721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918004722 catalytic residue [active] 189918004723 multidrug resistance protein MdtH; Provisional; Region: PRK11646 189918004724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918004725 putative substrate translocation pore; other site 189918004726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918004727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918004728 DNA binding site [nucleotide binding] 189918004729 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918004730 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918004731 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 189918004732 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918004733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918004734 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918004735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918004736 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918004737 metal-binding site [ion binding] 189918004738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189918004739 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918004740 metal-binding site [ion binding] 189918004741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918004742 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918004743 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 189918004744 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918004745 putative homodimer interface [polypeptide binding]; other site 189918004746 putative homotetramer interface [polypeptide binding]; other site 189918004747 putative allosteric switch controlling residues; other site 189918004748 putative metal binding site [ion binding]; other site 189918004749 putative homodimer-homodimer interface [polypeptide binding]; other site 189918004750 HTH-like domain; Region: HTH_21; pfam13276 189918004751 Integrase core domain; Region: rve; pfam00665 189918004752 Integrase core domain; Region: rve_3; pfam13683 189918004753 Transposase; Region: HTH_Tnp_1; pfam01527 189918004754 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918004755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918004756 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 189918004757 Walker A/P-loop; other site 189918004758 ATP binding site [chemical binding]; other site 189918004759 Q-loop/lid; other site 189918004760 ABC transporter signature motif; other site 189918004761 Walker B; other site 189918004762 D-loop; other site 189918004763 H-loop/switch region; other site 189918004764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189918004765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918004766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918004767 Transposase; Region: HTH_Tnp_1; cl17663 189918004768 putative transposase OrfB; Reviewed; Region: PHA02517 189918004769 HTH-like domain; Region: HTH_21; pfam13276 189918004770 Integrase core domain; Region: rve; pfam00665 189918004771 Integrase core domain; Region: rve_3; cl15866 189918004772 Predicted membrane protein [Function unknown]; Region: COG3462 189918004773 Short C-terminal domain; Region: SHOCT; pfam09851 189918004774 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918004775 MULE transposase domain; Region: MULE; pfam10551 189918004776 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 189918004777 active site 189918004778 catalytic triad [active] 189918004779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918004780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918004781 Walker A motif; other site 189918004782 ATP binding site [chemical binding]; other site 189918004783 Walker B motif; other site 189918004784 arginine finger; other site 189918004785 Thioredoxin; Region: Thioredoxin_4; pfam13462 189918004786 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 189918004787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918004788 dimerization interface [polypeptide binding]; other site 189918004789 putative DNA binding site [nucleotide binding]; other site 189918004790 putative Zn2+ binding site [ion binding]; other site 189918004791 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 189918004792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918004793 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918004794 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 189918004795 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 189918004796 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 189918004797 TIR domain; Region: TIR_2; pfam13676 189918004798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918004799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918004800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 189918004801 dimerization interface [polypeptide binding]; other site 189918004802 short chain dehydrogenase; Provisional; Region: PRK06500 189918004803 classical (c) SDRs; Region: SDR_c; cd05233 189918004804 NAD(P) binding site [chemical binding]; other site 189918004805 active site 189918004806 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918004807 DinB superfamily; Region: DinB_2; pfam12867 189918004808 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918004809 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 189918004810 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189918004811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004813 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918004814 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918004815 putative acyl-acceptor binding pocket; other site 189918004816 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918004817 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918004818 NAD(P) binding site [chemical binding]; other site 189918004819 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 189918004820 Transglycosylase; Region: Transgly; pfam00912 189918004821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189918004822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918004823 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 189918004824 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 189918004825 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918004826 Cytochrome P450; Region: p450; cl12078 189918004827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004829 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 189918004830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918004831 dimerization interface [polypeptide binding]; other site 189918004832 putative DNA binding site [nucleotide binding]; other site 189918004833 putative Zn2+ binding site [ion binding]; other site 189918004834 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 189918004835 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 189918004836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004838 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 189918004839 Predicted membrane protein [Function unknown]; Region: COG2259 189918004840 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 189918004841 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 189918004842 G1 box; other site 189918004843 putative GEF interaction site [polypeptide binding]; other site 189918004844 GTP/Mg2+ binding site [chemical binding]; other site 189918004845 Switch I region; other site 189918004846 G2 box; other site 189918004847 G3 box; other site 189918004848 Switch II region; other site 189918004849 G4 box; other site 189918004850 G5 box; other site 189918004851 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 189918004852 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 189918004853 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918004854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918004855 NAD(P) binding site [chemical binding]; other site 189918004856 active site 189918004857 enoyl-CoA hydratase; Provisional; Region: PRK08260 189918004858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918004859 substrate binding site [chemical binding]; other site 189918004860 oxyanion hole (OAH) forming residues; other site 189918004861 trimer interface [polypeptide binding]; other site 189918004862 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 189918004863 acyl-CoA synthetase; Provisional; Region: PRK13391 189918004864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918004865 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918004866 acyl-activating enzyme (AAE) consensus motif; other site 189918004867 putative AMP binding site [chemical binding]; other site 189918004868 putative active site [active] 189918004869 acyl-activating enzyme (AAE) consensus motif; other site 189918004870 putative CoA binding site [chemical binding]; other site 189918004871 CoA binding site [chemical binding]; other site 189918004872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918004873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918004874 active site 189918004875 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 189918004876 classical (c) SDRs; Region: SDR_c; cd05233 189918004877 NAD(P) binding site [chemical binding]; other site 189918004878 active site 189918004879 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918004880 Phosphotransferase enzyme family; Region: APH; pfam01636 189918004881 putative active site [active] 189918004882 putative substrate binding site [chemical binding]; other site 189918004883 ATP binding site [chemical binding]; other site 189918004884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004888 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 189918004889 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 189918004890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918004891 active site 189918004892 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 189918004893 putative transposase OrfB; Reviewed; Region: PHA02517 189918004894 HTH-like domain; Region: HTH_21; pfam13276 189918004895 Integrase core domain; Region: rve; pfam00665 189918004896 Integrase core domain; Region: rve_3; pfam13683 189918004897 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 189918004898 Winged helix-turn helix; Region: HTH_29; pfam13551 189918004899 Integrase core domain; Region: rve; pfam00665 189918004900 Integrase core domain; Region: rve_3; pfam13683 189918004901 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 189918004902 CoA binding domain; Region: CoA_binding_2; pfam13380 189918004903 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 189918004904 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 189918004905 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 189918004906 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918004907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918004908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918004909 active site 189918004910 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918004911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918004912 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918004913 acyl-activating enzyme (AAE) consensus motif; other site 189918004914 putative AMP binding site [chemical binding]; other site 189918004915 putative active site [active] 189918004916 putative CoA binding site [chemical binding]; other site 189918004917 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 189918004918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918004919 substrate binding site [chemical binding]; other site 189918004920 oxyanion hole (OAH) forming residues; other site 189918004921 trimer interface [polypeptide binding]; other site 189918004922 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189918004923 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 189918004924 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 189918004925 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918004926 dimer interface [polypeptide binding]; other site 189918004927 active site 189918004928 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918004929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918004930 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 189918004931 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 189918004932 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918004933 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918004934 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 189918004935 FMN-binding pocket [chemical binding]; other site 189918004936 flavin binding motif; other site 189918004937 phosphate binding motif [ion binding]; other site 189918004938 beta-alpha-beta structure motif; other site 189918004939 NAD binding pocket [chemical binding]; other site 189918004940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918004941 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 189918004942 catalytic loop [active] 189918004943 iron binding site [ion binding]; other site 189918004944 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918004945 Cytochrome P450; Region: p450; cl12078 189918004946 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918004947 Permease; Region: Permease; pfam02405 189918004948 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918004949 Permease; Region: Permease; pfam02405 189918004950 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918004951 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918004952 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918004953 mce related protein; Region: MCE; pfam02470 189918004954 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918004955 mce related protein; Region: MCE; pfam02470 189918004956 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918004957 mce related protein; Region: MCE; pfam02470 189918004958 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918004959 mce related protein; Region: MCE; pfam02470 189918004960 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918004961 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 189918004962 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 189918004963 classical (c) SDRs; Region: SDR_c; cd05233 189918004964 NAD(P) binding site [chemical binding]; other site 189918004965 active site 189918004966 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918004967 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918004968 substrate binding pocket [chemical binding]; other site 189918004969 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918004970 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 189918004971 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 189918004972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918004975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918004976 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 189918004977 active site 189918004978 catalytic site [active] 189918004979 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918004980 active site 189918004981 catalytic site [active] 189918004982 lipid-transfer protein; Provisional; Region: PRK08256 189918004983 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918004984 active site 189918004985 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918004986 classical (c) SDRs; Region: SDR_c; cd05233 189918004987 NAD(P) binding site [chemical binding]; other site 189918004988 active site 189918004989 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918004990 cyclase homology domain; Region: CHD; cd07302 189918004991 nucleotidyl binding site; other site 189918004992 metal binding site [ion binding]; metal-binding site 189918004993 dimer interface [polypeptide binding]; other site 189918004994 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918004995 hypothetical protein; Provisional; Region: PRK08244 189918004996 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 189918004997 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 189918004998 FAD binding site [chemical binding]; other site 189918004999 Methyltransferase domain; Region: Methyltransf_11; pfam08241 189918005000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005001 Dynamin family; Region: Dynamin_N; pfam00350 189918005002 YfjP GTPase; Region: YfjP; cd11383 189918005003 G1 box; other site 189918005004 Walker A/P-loop; other site 189918005005 GTP/Mg2+ binding site [chemical binding]; other site 189918005006 ATP binding site [chemical binding]; other site 189918005007 Switch I region; other site 189918005008 G2 box; other site 189918005009 Switch II region; other site 189918005010 G3 box; other site 189918005011 G4 box; other site 189918005012 G5 box; other site 189918005013 Dynamin family; Region: Dynamin_N; pfam00350 189918005014 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 189918005015 G1 box; other site 189918005016 GTP/Mg2+ binding site [chemical binding]; other site 189918005017 G2 box; other site 189918005018 Switch I region; other site 189918005019 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 189918005020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005022 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 189918005023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005024 NAD(P) binding site [chemical binding]; other site 189918005025 active site 189918005026 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918005027 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 189918005028 NAD(P) binding site [chemical binding]; other site 189918005029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918005030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918005031 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 189918005032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918005033 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 189918005034 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 189918005035 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918005036 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918005037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918005038 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918005039 putative active site [active] 189918005040 putative substrate binding site [chemical binding]; other site 189918005041 ATP binding site [chemical binding]; other site 189918005042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005044 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 189918005045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005046 Walker A/P-loop; other site 189918005047 ATP binding site [chemical binding]; other site 189918005048 Q-loop/lid; other site 189918005049 ABC transporter signature motif; other site 189918005050 Walker B; other site 189918005051 D-loop; other site 189918005052 H-loop/switch region; other site 189918005053 enoyl-CoA hydratase; Provisional; Region: PRK06190 189918005054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005055 substrate binding site [chemical binding]; other site 189918005056 oxyanion hole (OAH) forming residues; other site 189918005057 trimer interface [polypeptide binding]; other site 189918005058 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 189918005059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189918005060 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 189918005061 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189918005062 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 189918005063 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 189918005064 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189918005065 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 189918005066 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 189918005067 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 189918005068 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 189918005069 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 189918005070 Binuclear center (active site) [active] 189918005071 K-pathway; other site 189918005072 Putative proton exit pathway; other site 189918005073 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 189918005074 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 189918005075 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 189918005076 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 189918005077 4Fe-4S binding domain; Region: Fer4; pfam00037 189918005078 4Fe-4S binding domain; Region: Fer4; pfam00037 189918005079 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 189918005080 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 189918005081 NADH dehydrogenase subunit G; Validated; Region: PRK07860 189918005082 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918005083 catalytic loop [active] 189918005084 iron binding site [ion binding]; other site 189918005085 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 189918005086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918005087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918005088 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 189918005089 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 189918005090 SLBB domain; Region: SLBB; pfam10531 189918005091 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 189918005092 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 189918005093 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 189918005094 putative dimer interface [polypeptide binding]; other site 189918005095 [2Fe-2S] cluster binding site [ion binding]; other site 189918005096 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 189918005097 NADH dehydrogenase subunit D; Validated; Region: PRK06075 189918005098 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 189918005099 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 189918005100 NADH dehydrogenase subunit A; Validated; Region: PRK07928 189918005101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 189918005102 active site 189918005103 phosphorylation site [posttranslational modification] 189918005104 intermolecular recognition site; other site 189918005105 dimerization interface [polypeptide binding]; other site 189918005106 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918005107 Methyltransferase domain; Region: Methyltransf_25; pfam13649 189918005108 S-adenosylmethionine binding site [chemical binding]; other site 189918005109 Phosphotransferase enzyme family; Region: APH; pfam01636 189918005110 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918005111 putative active site [active] 189918005112 putative substrate binding site [chemical binding]; other site 189918005113 ATP binding site [chemical binding]; other site 189918005114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005115 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918005116 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918005117 active site 189918005118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005120 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 189918005121 active site 189918005122 catalytic residues [active] 189918005123 metal binding site [ion binding]; metal-binding site 189918005124 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918005125 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918005126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918005127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918005128 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 189918005129 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918005130 hydrophobic ligand binding site; other site 189918005131 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918005132 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005133 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005134 active site 189918005135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005136 Putative esterase; Region: Esterase; pfam00756 189918005137 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 189918005138 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 189918005139 NADP binding site [chemical binding]; other site 189918005140 dimer interface [polypeptide binding]; other site 189918005141 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 189918005142 RibD C-terminal domain; Region: RibD_C; cl17279 189918005143 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 189918005144 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 189918005145 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 189918005146 Protein of unknown function (DUF461); Region: DUF461; pfam04314 189918005147 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 189918005148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005150 active site 189918005151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005153 active site 189918005154 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 189918005155 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 189918005156 active site 189918005157 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918005158 ferredoxin-NADP+ reductase; Region: PLN02852 189918005159 peptide chain release factor 2; Validated; Region: prfB; PRK00578 189918005160 This domain is found in peptide chain release factors; Region: PCRF; smart00937 189918005161 RF-1 domain; Region: RF-1; pfam00472 189918005162 Mechanosensitive ion channel; Region: MS_channel; pfam00924 189918005163 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189918005164 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 189918005165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005166 Walker A/P-loop; other site 189918005167 ATP binding site [chemical binding]; other site 189918005168 Q-loop/lid; other site 189918005169 ABC transporter signature motif; other site 189918005170 Walker B; other site 189918005171 D-loop; other site 189918005172 H-loop/switch region; other site 189918005173 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 189918005174 FtsX-like permease family; Region: FtsX; pfam02687 189918005175 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 189918005176 SmpB-tmRNA interface; other site 189918005177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918005178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918005179 metal binding site [ion binding]; metal-binding site 189918005180 active site 189918005181 I-site; other site 189918005182 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189918005183 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918005184 PAS fold; Region: PAS_3; pfam08447 189918005185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918005186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918005187 active site 189918005188 phosphorylation site [posttranslational modification] 189918005189 intermolecular recognition site; other site 189918005190 dimerization interface [polypeptide binding]; other site 189918005191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918005192 DNA binding residues [nucleotide binding] 189918005193 dimerization interface [polypeptide binding]; other site 189918005194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918005195 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 189918005196 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918005197 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005198 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918005199 iron-sulfur cluster [ion binding]; other site 189918005200 [2Fe-2S] cluster binding site [ion binding]; other site 189918005201 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005202 beta subunit interface [polypeptide binding]; other site 189918005203 alpha subunit interface [polypeptide binding]; other site 189918005204 active site 189918005205 substrate binding site [chemical binding]; other site 189918005206 Fe binding site [ion binding]; other site 189918005207 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005208 inter-subunit interface; other site 189918005209 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 189918005210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005211 NAD(P) binding site [chemical binding]; other site 189918005212 active site 189918005213 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 189918005214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918005215 HTH-like domain; Region: HTH_21; pfam13276 189918005216 Integrase core domain; Region: rve; pfam00665 189918005217 Integrase core domain; Region: rve_3; pfam13683 189918005218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189918005219 Transposase; Region: HTH_Tnp_1; pfam01527 189918005220 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 189918005221 Cupin domain; Region: Cupin_2; pfam07883 189918005222 Cupin domain; Region: Cupin_2; pfam07883 189918005223 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 189918005224 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918005225 putative active site [active] 189918005226 catalytic residue [active] 189918005227 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 189918005228 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 189918005229 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 189918005230 active site 189918005231 Fe binding site [ion binding]; other site 189918005232 SCP-2 sterol transfer family; Region: SCP2; pfam02036 189918005233 Class I aldolases; Region: Aldolase_Class_I; cl17187 189918005234 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918005235 catalytic residue [active] 189918005236 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005237 inter-subunit interface; other site 189918005238 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 189918005239 L-aspartate oxidase; Provisional; Region: PRK06175 189918005240 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918005241 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 189918005242 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189918005243 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918005244 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 189918005245 NAD(P) binding site [chemical binding]; other site 189918005246 catalytic residues [active] 189918005247 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005248 inter-subunit interface; other site 189918005249 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005250 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918005251 alpha subunit interaction site [polypeptide binding]; other site 189918005252 beta subunit interaction site [polypeptide binding]; other site 189918005253 iron-sulfur cluster [ion binding]; other site 189918005254 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005255 beta subunit interface [polypeptide binding]; other site 189918005256 alpha subunit interface [polypeptide binding]; other site 189918005257 active site 189918005258 substrate binding site [chemical binding]; other site 189918005259 Fe binding site [ion binding]; other site 189918005260 short chain dehydrogenase; Provisional; Region: PRK06138 189918005261 classical (c) SDRs; Region: SDR_c; cd05233 189918005262 NAD(P) binding site [chemical binding]; other site 189918005263 active site 189918005264 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918005265 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 189918005266 putative NAD(P) binding site [chemical binding]; other site 189918005267 catalytic Zn binding site [ion binding]; other site 189918005268 VPS10 domain; Region: VPS10; smart00602 189918005269 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005270 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918005271 [2Fe-2S] cluster binding site [ion binding]; other site 189918005272 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918005273 hydrophobic ligand binding site; other site 189918005274 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918005275 SCP-2 sterol transfer family; Region: SCP2; pfam02036 189918005276 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918005277 active site 189918005278 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918005279 Permease; Region: Permease; pfam02405 189918005280 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918005281 Permease; Region: Permease; pfam02405 189918005282 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005283 mce related protein; Region: MCE; pfam02470 189918005284 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918005285 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005286 mce related protein; Region: MCE; pfam02470 189918005287 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918005288 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005289 mce related protein; Region: MCE; pfam02470 189918005290 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005291 mce related protein; Region: MCE; pfam02470 189918005292 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918005293 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005294 mce related protein; Region: MCE; pfam02470 189918005295 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918005296 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918005297 mce related protein; Region: MCE; pfam02470 189918005298 Epoxide hydrolase N terminus; Region: EHN; pfam06441 189918005299 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918005300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918005301 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 189918005302 NAD(P) binding site [chemical binding]; other site 189918005303 catalytic residues [active] 189918005304 catalytic residues [active] 189918005305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918005306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918005307 putative substrate translocation pore; other site 189918005308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 189918005309 MarR family; Region: MarR; pfam01047 189918005310 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005311 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918005312 alpha subunit interaction site [polypeptide binding]; other site 189918005313 beta subunit interaction site [polypeptide binding]; other site 189918005314 iron-sulfur cluster [ion binding]; other site 189918005315 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005316 beta subunit interface [polypeptide binding]; other site 189918005317 alpha subunit interface [polypeptide binding]; other site 189918005318 active site 189918005319 substrate binding site [chemical binding]; other site 189918005320 Fe binding site [ion binding]; other site 189918005321 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005322 inter-subunit interface; other site 189918005323 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918005324 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 189918005325 putative NAD(P) binding site [chemical binding]; other site 189918005326 catalytic Zn binding site [ion binding]; other site 189918005327 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918005328 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918005329 lipid-transfer protein; Provisional; Region: PRK07855 189918005330 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918005331 active site 189918005332 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918005333 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918005334 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918005335 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918005336 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918005337 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 189918005338 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918005339 iron-sulfur cluster [ion binding]; other site 189918005340 [2Fe-2S] cluster binding site [ion binding]; other site 189918005341 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005342 beta subunit interface [polypeptide binding]; other site 189918005343 alpha subunit interface [polypeptide binding]; other site 189918005344 active site 189918005345 substrate binding site [chemical binding]; other site 189918005346 Fe binding site [ion binding]; other site 189918005347 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005348 inter-subunit interface; other site 189918005349 Cupin domain; Region: Cupin_2; pfam07883 189918005350 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918005351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918005352 MarR family; Region: MarR; pfam01047 189918005353 MarR family; Region: MarR_2; cl17246 189918005354 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918005355 MULE transposase domain; Region: MULE; pfam10551 189918005356 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 189918005357 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 189918005358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918005359 active site 189918005360 DNA binding site [nucleotide binding] 189918005361 Int/Topo IB signature motif; other site 189918005362 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 189918005363 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918005364 active site 189918005365 DNA binding site [nucleotide binding] 189918005366 Int/Topo IB signature motif; other site 189918005367 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918005368 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918005369 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918005370 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005371 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918005372 iron-sulfur cluster [ion binding]; other site 189918005373 [2Fe-2S] cluster binding site [ion binding]; other site 189918005374 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005375 beta subunit interface [polypeptide binding]; other site 189918005376 alpha subunit interface [polypeptide binding]; other site 189918005377 active site 189918005378 substrate binding site [chemical binding]; other site 189918005379 Fe binding site [ion binding]; other site 189918005380 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005381 inter-subunit interface; other site 189918005382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189918005383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189918005384 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189918005385 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 189918005386 active site 189918005387 metal binding site [ion binding]; metal-binding site 189918005388 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 189918005389 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 189918005390 intersubunit interface [polypeptide binding]; other site 189918005391 active site 189918005392 Zn2+ binding site [ion binding]; other site 189918005393 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 189918005394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005395 NAD(P) binding site [chemical binding]; other site 189918005396 active site 189918005397 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 189918005398 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 189918005399 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 189918005400 active site 189918005401 Fe binding site [ion binding]; other site 189918005402 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918005403 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 189918005404 alpha subunit interaction site [polypeptide binding]; other site 189918005405 beta subunit interaction site [polypeptide binding]; other site 189918005406 iron-sulfur cluster [ion binding]; other site 189918005407 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 189918005408 beta subunit interface [polypeptide binding]; other site 189918005409 alpha subunit interface [polypeptide binding]; other site 189918005410 active site 189918005411 substrate binding site [chemical binding]; other site 189918005412 Fe binding site [ion binding]; other site 189918005413 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 189918005414 inter-subunit interface; other site 189918005415 Transposase; Region: HTH_Tnp_1; pfam01527 189918005416 HTH-like domain; Region: HTH_21; pfam13276 189918005417 Integrase core domain; Region: rve; pfam00665 189918005418 Integrase core domain; Region: rve_3; pfam13683 189918005419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918005420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918005421 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 189918005422 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 189918005423 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 189918005424 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918005425 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 189918005426 active site 189918005427 inhibitor site; inhibition site 189918005428 dimer interface [polypeptide binding]; other site 189918005429 catalytic residue [active] 189918005430 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918005431 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 189918005432 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918005433 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918005434 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 189918005435 active site 189918005436 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918005437 active site 189918005438 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 189918005439 Lyase; Region: Lyase_1; pfam00206 189918005440 tetramer interface [polypeptide binding]; other site 189918005441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918005442 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 189918005443 Coenzyme A transferase; Region: CoA_trans; cl17247 189918005444 Coenzyme A transferase; Region: CoA_trans; cl17247 189918005445 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918005446 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 189918005447 Cupin domain; Region: Cupin_2; pfam07883 189918005448 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918005449 Transposase; Region: HTH_Tnp_1; pfam01527 189918005450 HTH-like domain; Region: HTH_21; pfam13276 189918005451 Integrase core domain; Region: rve; pfam00665 189918005452 Integrase core domain; Region: rve_3; pfam13683 189918005453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918005454 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918005455 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 189918005456 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 189918005457 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 189918005458 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918005459 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 189918005460 active site 189918005461 inhibitor site; inhibition site 189918005462 dimer interface [polypeptide binding]; other site 189918005463 catalytic residue [active] 189918005464 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918005465 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 189918005466 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918005467 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918005468 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 189918005469 active site 189918005470 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 189918005471 active site 189918005472 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 189918005473 Lyase; Region: Lyase_1; pfam00206 189918005474 tetramer interface [polypeptide binding]; other site 189918005475 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918005476 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 189918005477 Coenzyme A transferase; Region: CoA_trans; cl17247 189918005478 Coenzyme A transferase; Region: CoA_trans; cl17247 189918005479 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918005480 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 189918005481 Cupin domain; Region: Cupin_2; pfam07883 189918005482 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918005483 Transposase; Region: HTH_Tnp_1; pfam01527 189918005484 HTH-like domain; Region: HTH_21; pfam13276 189918005485 Integrase core domain; Region: rve; pfam00665 189918005486 Integrase core domain; Region: rve_3; pfam13683 189918005487 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 189918005488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005489 NAD(P) binding site [chemical binding]; other site 189918005490 active site 189918005491 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 189918005492 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 189918005493 putative active site [active] 189918005494 catalytic triad [active] 189918005495 putative dimer interface [polypeptide binding]; other site 189918005496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 189918005497 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918005498 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918005499 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918005500 G5 domain; Region: G5; pfam07501 189918005501 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918005502 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 189918005503 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189918005504 putative NAD(P) binding site [chemical binding]; other site 189918005505 catalytic Zn binding site [ion binding]; other site 189918005506 structural Zn binding site [ion binding]; other site 189918005507 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 189918005508 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918005509 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918005510 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 189918005511 Cytochrome P450; Region: p450; cl12078 189918005512 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918005513 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 189918005514 active site 189918005515 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 189918005516 putative deacylase active site [active] 189918005517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 189918005518 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 189918005519 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918005520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005521 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918005522 active site 189918005523 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 189918005524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005525 acyl-activating enzyme (AAE) consensus motif; other site 189918005526 AMP binding site [chemical binding]; other site 189918005527 active site 189918005528 CoA binding site [chemical binding]; other site 189918005529 acyl carrier protein; Validated; Region: PRK05883 189918005530 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 189918005531 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 189918005532 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 189918005533 camphor resistance protein CrcB; Provisional; Region: PRK14228 189918005534 camphor resistance protein CrcB; Provisional; Region: PRK14216 189918005535 phosphoglucomutase; Validated; Region: PRK07564 189918005536 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 189918005537 active site 189918005538 substrate binding site [chemical binding]; other site 189918005539 metal binding site [ion binding]; metal-binding site 189918005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918005541 putative substrate translocation pore; other site 189918005542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918005543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918005544 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918005545 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918005546 active site 189918005547 Winged helix-turn helix; Region: HTH_29; pfam13551 189918005548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 189918005549 Integrase core domain; Region: rve; pfam00665 189918005550 Integrase core domain; Region: rve_3; pfam13683 189918005551 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918005552 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 189918005553 PE-PPE domain; Region: PE-PPE; pfam08237 189918005554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918005555 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918005556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918005557 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918005558 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 189918005559 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189918005560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005561 ABC transporter signature motif; other site 189918005562 Walker B; other site 189918005563 D-loop; other site 189918005564 H-loop/switch region; other site 189918005565 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 189918005566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005567 Walker A/P-loop; other site 189918005568 ATP binding site [chemical binding]; other site 189918005569 Q-loop/lid; other site 189918005570 ABC transporter signature motif; other site 189918005571 Walker B; other site 189918005572 D-loop; other site 189918005573 H-loop/switch region; other site 189918005574 Conserved TM helix; Region: TM_helix; pfam05552 189918005575 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189918005576 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 189918005577 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 189918005578 active site 189918005579 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 189918005580 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918005581 active site 189918005582 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 189918005583 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005584 active site 189918005585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189918005586 PAS domain; Region: PAS_9; pfam13426 189918005587 putative active site [active] 189918005588 heme pocket [chemical binding]; other site 189918005589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005592 putative succinate dehydrogenase; Reviewed; Region: PRK12842 189918005593 GAF domain; Region: GAF; cl17456 189918005594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918005595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918005596 metal binding site [ion binding]; metal-binding site 189918005597 active site 189918005598 I-site; other site 189918005599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189918005600 hypothetical protein; Provisional; Region: PRK07877 189918005601 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 189918005602 ATP binding site [chemical binding]; other site 189918005603 substrate interface [chemical binding]; other site 189918005604 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918005605 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 189918005606 putative active site [active] 189918005607 putative catalytic site [active] 189918005608 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 189918005609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918005610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005612 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918005613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918005614 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918005615 classical (c) SDRs; Region: SDR_c; cd05233 189918005616 NAD(P) binding site [chemical binding]; other site 189918005617 active site 189918005618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005620 active site 189918005621 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005623 NAD(P) binding site [chemical binding]; other site 189918005624 active site 189918005625 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 189918005626 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918005627 dimer interface [polypeptide binding]; other site 189918005628 active site 189918005629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005631 active site 189918005632 Transcriptional regulators [Transcription]; Region: GntR; COG1802 189918005633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918005634 DNA-binding site [nucleotide binding]; DNA binding site 189918005635 FCD domain; Region: FCD; pfam07729 189918005636 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918005637 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005639 acyl-activating enzyme (AAE) consensus motif; other site 189918005640 acyl-activating enzyme (AAE) consensus motif; other site 189918005641 AMP binding site [chemical binding]; other site 189918005642 active site 189918005643 CoA binding site [chemical binding]; other site 189918005644 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918005645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005647 acyl-activating enzyme (AAE) consensus motif; other site 189918005648 AMP binding site [chemical binding]; other site 189918005649 active site 189918005650 CoA binding site [chemical binding]; other site 189918005651 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918005652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005653 AMP binding site [chemical binding]; other site 189918005654 active site 189918005655 acyl-activating enzyme (AAE) consensus motif; other site 189918005656 CoA binding site [chemical binding]; other site 189918005657 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918005658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005659 substrate binding site [chemical binding]; other site 189918005660 oxyanion hole (OAH) forming residues; other site 189918005661 trimer interface [polypeptide binding]; other site 189918005662 enoyl-CoA hydratase; Provisional; Region: PRK06494 189918005663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005664 substrate binding site [chemical binding]; other site 189918005665 oxyanion hole (OAH) forming residues; other site 189918005666 trimer interface [polypeptide binding]; other site 189918005667 enoyl-CoA hydratase; Provisional; Region: PRK06688 189918005668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005669 substrate binding site [chemical binding]; other site 189918005670 oxyanion hole (OAH) forming residues; other site 189918005671 trimer interface [polypeptide binding]; other site 189918005672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005673 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 189918005674 substrate binding site [chemical binding]; other site 189918005675 oxyanion hole (OAH) forming residues; other site 189918005676 trimer interface [polypeptide binding]; other site 189918005677 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918005678 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 189918005679 dimer interface [polypeptide binding]; other site 189918005680 active site 189918005681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005682 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 189918005683 enoyl-CoA hydratase; Provisional; Region: PRK08252 189918005684 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005685 substrate binding site [chemical binding]; other site 189918005686 oxyanion hole (OAH) forming residues; other site 189918005687 trimer interface [polypeptide binding]; other site 189918005688 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918005689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005690 NAD(P) binding site [chemical binding]; other site 189918005691 active site 189918005692 enoyl-CoA hydratase; Provisional; Region: PRK06210 189918005693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005694 substrate binding site [chemical binding]; other site 189918005695 oxyanion hole (OAH) forming residues; other site 189918005696 trimer interface [polypeptide binding]; other site 189918005697 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918005698 acyl-CoA synthetase; Validated; Region: PRK07798 189918005699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005700 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 189918005701 acyl-activating enzyme (AAE) consensus motif; other site 189918005702 acyl-activating enzyme (AAE) consensus motif; other site 189918005703 putative AMP binding site [chemical binding]; other site 189918005704 putative active site [active] 189918005705 putative CoA binding site [chemical binding]; other site 189918005706 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 189918005707 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918005708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005709 active site 189918005710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918005711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918005712 active site 189918005713 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 189918005714 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918005715 active site 189918005716 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918005717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918005718 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 189918005719 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 189918005720 NAD binding site [chemical binding]; other site 189918005721 catalytic residues [active] 189918005722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918005723 Cytochrome P450; Region: p450; cl12078 189918005724 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918005725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918005726 NAD(P) binding site [chemical binding]; other site 189918005727 catalytic residues [active] 189918005728 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918005729 Cytochrome P450; Region: p450; cl12078 189918005730 acyl-CoA synthetase; Validated; Region: PRK07798 189918005731 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918005732 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 189918005733 acyl-activating enzyme (AAE) consensus motif; other site 189918005734 putative AMP binding site [chemical binding]; other site 189918005735 putative active site [active] 189918005736 putative CoA binding site [chemical binding]; other site 189918005737 Isochorismatase family; Region: Isochorismatase; pfam00857 189918005738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 189918005739 catalytic triad [active] 189918005740 conserved cis-peptide bond; other site 189918005741 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918005742 iron-sulfur cluster [ion binding]; other site 189918005743 [2Fe-2S] cluster binding site [ion binding]; other site 189918005744 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 189918005745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005746 NAD(P) binding site [chemical binding]; other site 189918005747 active site 189918005748 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918005749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918005750 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918005751 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 189918005752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918005753 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918005754 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918005755 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918005756 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 189918005757 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918005758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918005759 Cytochrome P450; Region: p450; cl12078 189918005760 Protein of unknown function (DUF466); Region: DUF466; pfam04328 189918005761 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 189918005762 Carbon starvation protein CstA; Region: CstA; pfam02554 189918005763 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 189918005764 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 189918005765 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 189918005766 active site 189918005767 DNA binding site [nucleotide binding] 189918005768 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 189918005769 DNA binding site [nucleotide binding] 189918005770 Yqey-like protein; Region: YqeY; cl17540 189918005771 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 189918005772 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 189918005773 Moco binding site; other site 189918005774 metal coordination site [ion binding]; other site 189918005775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005776 NAD(P) binding site [chemical binding]; other site 189918005777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918005778 active site 189918005779 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918005780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918005781 dimerization interface [polypeptide binding]; other site 189918005782 putative DNA binding site [nucleotide binding]; other site 189918005783 putative Zn2+ binding site [ion binding]; other site 189918005784 SCP-2 sterol transfer family; Region: SCP2; cl01225 189918005785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918005786 S-adenosylmethionine binding site [chemical binding]; other site 189918005787 Phosphotransferase enzyme family; Region: APH; pfam01636 189918005788 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918005789 putative active site [active] 189918005790 putative substrate binding site [chemical binding]; other site 189918005791 ATP binding site [chemical binding]; other site 189918005792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918005793 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 189918005794 Cytochrome P450; Region: p450; cl12078 189918005795 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918005796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005798 short chain dehydrogenase; Provisional; Region: PRK07832 189918005799 classical (c) SDRs; Region: SDR_c; cd05233 189918005800 NAD(P) binding site [chemical binding]; other site 189918005801 active site 189918005802 Predicted ATPase [General function prediction only]; Region: COG4637 189918005803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005804 Walker A/P-loop; other site 189918005805 ATP binding site [chemical binding]; other site 189918005806 DNA polymerase IV; Validated; Region: PRK03352 189918005807 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 189918005808 active site 189918005809 DNA binding site [nucleotide binding] 189918005810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005811 Predicted flavoprotein [General function prediction only]; Region: COG0431 189918005812 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189918005813 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 189918005814 catalytic residues [active] 189918005815 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 189918005816 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 189918005817 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 189918005818 Class I ribonucleotide reductase; Region: RNR_I; cd01679 189918005819 active site 189918005820 dimer interface [polypeptide binding]; other site 189918005821 catalytic residues [active] 189918005822 effector binding site; other site 189918005823 R2 peptide binding site; other site 189918005824 Predicted membrane protein [Function unknown]; Region: COG3174 189918005825 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 189918005826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 189918005827 dimerization interface [polypeptide binding]; other site 189918005828 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918005829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918005830 NAD(P) binding site [chemical binding]; other site 189918005831 active site 189918005832 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 189918005833 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 189918005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 189918005835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005836 agmatinase; Region: agmatinase; TIGR01230 189918005837 Agmatinase-like family; Region: Agmatinase-like; cd09990 189918005838 active site 189918005839 oligomer interface [polypeptide binding]; other site 189918005840 Mn binding site [ion binding]; other site 189918005841 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 189918005842 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918005843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005845 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 189918005846 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 189918005847 dimer interface [polypeptide binding]; other site 189918005848 putative radical transfer pathway; other site 189918005849 diiron center [ion binding]; other site 189918005850 tyrosyl radical; other site 189918005851 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918005852 potassium efflux protein KefA; Provisional; Region: PRK11281 189918005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918005854 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918005855 putative substrate translocation pore; other site 189918005856 Putative esterase; Region: Esterase; pfam00756 189918005857 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189918005858 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 189918005859 putative NAD(P) binding site [chemical binding]; other site 189918005860 putative substrate binding site [chemical binding]; other site 189918005861 catalytic Zn binding site [ion binding]; other site 189918005862 structural Zn binding site [ion binding]; other site 189918005863 dimer interface [polypeptide binding]; other site 189918005864 YCII-related domain; Region: YCII; cl00999 189918005865 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 189918005866 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 189918005867 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 189918005868 urea carboxylase; Region: urea_carbox; TIGR02712 189918005869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918005870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918005871 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 189918005872 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 189918005873 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 189918005874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918005875 carboxyltransferase (CT) interaction site; other site 189918005876 biotinylation site [posttranslational modification]; other site 189918005877 allophanate hydrolase; Provisional; Region: PRK08186 189918005878 Amidase; Region: Amidase; cl11426 189918005879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918005880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918005881 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 189918005882 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918005883 Walker A/P-loop; other site 189918005884 ATP binding site [chemical binding]; other site 189918005885 Q-loop/lid; other site 189918005886 ABC transporter signature motif; other site 189918005887 Walker B; other site 189918005888 D-loop; other site 189918005889 H-loop/switch region; other site 189918005890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189918005891 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 189918005892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918005893 Walker A/P-loop; other site 189918005894 ATP binding site [chemical binding]; other site 189918005895 Q-loop/lid; other site 189918005896 ABC transporter signature motif; other site 189918005897 Walker B; other site 189918005898 D-loop; other site 189918005899 H-loop/switch region; other site 189918005900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189918005901 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 189918005902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918005903 ABC-ATPase subunit interface; other site 189918005904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 189918005905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918005906 dimer interface [polypeptide binding]; other site 189918005907 conserved gate region; other site 189918005908 putative PBP binding loops; other site 189918005909 ABC-ATPase subunit interface; other site 189918005910 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 189918005911 catalytic triad [active] 189918005912 Isochorismatase family; Region: Isochorismatase; pfam00857 189918005913 conserved cis-peptide bond; other site 189918005914 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 189918005915 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 189918005916 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918005917 oxidase reductase; Provisional; Region: PTZ00273 189918005918 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 189918005919 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 189918005920 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 189918005921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 189918005922 siderophore binding site; other site 189918005923 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 189918005924 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 189918005925 D-pathway; other site 189918005926 Putative ubiquinol binding site [chemical binding]; other site 189918005927 Low-spin heme (heme b) binding site [chemical binding]; other site 189918005928 Putative water exit pathway; other site 189918005929 Binuclear center (heme o3/CuB) [ion binding]; other site 189918005930 K-pathway; other site 189918005931 Putative proton exit pathway; other site 189918005932 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 189918005933 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 189918005934 phosphoserine phosphatase SerB; Region: serB; TIGR00338 189918005935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918005936 motif II; other site 189918005937 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 189918005938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918005939 DNA-binding site [nucleotide binding]; DNA binding site 189918005940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918005941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918005942 homodimer interface [polypeptide binding]; other site 189918005943 catalytic residue [active] 189918005944 Predicted membrane protein [Function unknown]; Region: COG2364 189918005945 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 189918005946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918005947 Walker A/P-loop; other site 189918005948 ATP binding site [chemical binding]; other site 189918005949 Q-loop/lid; other site 189918005950 ABC transporter signature motif; other site 189918005951 Walker B; other site 189918005952 D-loop; other site 189918005953 H-loop/switch region; other site 189918005954 NUDIX domain; Region: NUDIX; pfam00293 189918005955 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918005956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918005957 substrate binding site [chemical binding]; other site 189918005958 oxyanion hole (OAH) forming residues; other site 189918005959 trimer interface [polypeptide binding]; other site 189918005960 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 189918005961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918005962 S-adenosylmethionine binding site [chemical binding]; other site 189918005963 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 189918005964 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 189918005965 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 189918005966 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 189918005967 FOG: WD40-like repeat [Function unknown]; Region: COG1520 189918005968 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 189918005969 active site 189918005970 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 189918005971 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 189918005972 trimer interface [polypeptide binding]; other site 189918005973 active site 189918005974 substrate binding site [chemical binding]; other site 189918005975 CoA binding site [chemical binding]; other site 189918005976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918005977 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918005978 Uncharacterized conserved protein [Function unknown]; Region: COG1543 189918005979 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 189918005980 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 189918005981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918005982 S-adenosylmethionine binding site [chemical binding]; other site 189918005983 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 189918005984 Ligand binding site [chemical binding]; other site 189918005985 Electron transfer flavoprotein domain; Region: ETF; pfam01012 189918005986 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 189918005987 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 189918005988 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 189918005989 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918005990 classical (c) SDRs; Region: SDR_c; cd05233 189918005991 NAD(P) binding site [chemical binding]; other site 189918005992 active site 189918005993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 189918005994 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918005995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189918005996 putative acyl-acceptor binding pocket; other site 189918005997 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 189918005998 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 189918005999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918006000 catalytic residue [active] 189918006001 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 189918006002 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 189918006003 Ligand Binding Site [chemical binding]; other site 189918006004 PknH-like extracellular domain; Region: PknH_C; pfam14032 189918006005 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 189918006006 4-coumarate--CoA ligase; Region: PLN02246 189918006007 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 189918006008 acyl-activating enzyme (AAE) consensus motif; other site 189918006009 active site 189918006010 putative CoA binding site [chemical binding]; other site 189918006011 AMP binding site [chemical binding]; other site 189918006012 Protein of unknown function (DUF419); Region: DUF419; pfam04237 189918006013 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 189918006014 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 189918006015 nucleotide binding pocket [chemical binding]; other site 189918006016 K-X-D-G motif; other site 189918006017 catalytic site [active] 189918006018 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 189918006019 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 189918006020 Helix-hairpin-helix motif; Region: HHH; pfam00633 189918006021 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 189918006022 Dimer interface [polypeptide binding]; other site 189918006023 BRCT sequence motif; other site 189918006024 spermidine synthase; Provisional; Region: PRK03612 189918006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918006026 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 189918006027 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 189918006028 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 189918006029 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 189918006030 Hemerythrin-like domain; Region: Hr-like; cd12108 189918006031 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 189918006032 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 189918006033 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 189918006034 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 189918006035 6-phosphofructokinase; Provisional; Region: PRK03202 189918006036 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 189918006037 active site 189918006038 ADP/pyrophosphate binding site [chemical binding]; other site 189918006039 dimerization interface [polypeptide binding]; other site 189918006040 allosteric effector site; other site 189918006041 fructose-1,6-bisphosphate binding site; other site 189918006042 Cutinase; Region: Cutinase; pfam01083 189918006043 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 189918006044 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 189918006045 GatB domain; Region: GatB_Yqey; pfam02637 189918006046 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 189918006047 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918006048 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918006049 enoyl-CoA hydratase; Provisional; Region: PRK06495 189918006050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918006051 substrate binding site [chemical binding]; other site 189918006052 oxyanion hole (OAH) forming residues; other site 189918006053 trimer interface [polypeptide binding]; other site 189918006054 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918006055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918006056 active site 189918006057 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918006058 Phosphotransferase enzyme family; Region: APH; pfam01636 189918006059 putative active site [active] 189918006060 putative substrate binding site [chemical binding]; other site 189918006061 ATP binding site [chemical binding]; other site 189918006062 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 189918006063 classical (c) SDRs; Region: SDR_c; cd05233 189918006064 NAD(P) binding site [chemical binding]; other site 189918006065 active site 189918006066 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 189918006067 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 189918006068 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 189918006069 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 189918006070 PYR/PP interface [polypeptide binding]; other site 189918006071 dimer interface [polypeptide binding]; other site 189918006072 TPP binding site [chemical binding]; other site 189918006073 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 189918006074 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 189918006075 TPP-binding site [chemical binding]; other site 189918006076 dimer interface [polypeptide binding]; other site 189918006077 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 189918006078 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 189918006079 putative valine binding site [chemical binding]; other site 189918006080 dimer interface [polypeptide binding]; other site 189918006081 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 189918006082 ketol-acid reductoisomerase; Provisional; Region: PRK05479 189918006083 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 189918006084 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 189918006085 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 189918006086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918006087 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 189918006088 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 189918006089 ligand binding site [chemical binding]; other site 189918006090 NAD binding site [chemical binding]; other site 189918006091 dimerization interface [polypeptide binding]; other site 189918006092 catalytic site [active] 189918006093 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 189918006094 putative L-serine binding site [chemical binding]; other site 189918006095 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 189918006096 tartrate dehydrogenase; Region: TTC; TIGR02089 189918006097 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 189918006098 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 189918006099 active site 189918006100 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 189918006101 MarR family; Region: MarR_2; pfam12802 189918006102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918006103 putative substrate translocation pore; other site 189918006104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918006105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918006106 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 189918006107 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 189918006108 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 189918006109 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 189918006110 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 189918006111 active site 189918006112 HIGH motif; other site 189918006113 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 189918006114 active site 189918006115 KMSKS motif; other site 189918006116 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 189918006117 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918006118 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918006119 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 189918006120 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 189918006121 substrate binding site [chemical binding]; other site 189918006122 ligand binding site [chemical binding]; other site 189918006123 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 189918006124 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 189918006125 substrate binding site [chemical binding]; other site 189918006126 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 189918006127 IHF - DNA interface [nucleotide binding]; other site 189918006128 IHF dimer interface [polypeptide binding]; other site 189918006129 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 189918006130 active site 189918006131 Ap6A binding site [chemical binding]; other site 189918006132 nudix motif; other site 189918006133 metal binding site [ion binding]; metal-binding site 189918006134 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918006135 catalytic core [active] 189918006136 polyphosphate kinase; Provisional; Region: PRK05443 189918006137 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 189918006138 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 189918006139 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 189918006140 putative domain interface [polypeptide binding]; other site 189918006141 putative active site [active] 189918006142 catalytic site [active] 189918006143 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 189918006144 putative active site [active] 189918006145 catalytic site [active] 189918006146 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 189918006147 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 189918006148 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 189918006149 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 189918006150 cystathionine gamma-lyase; Validated; Region: PRK07582 189918006151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918006152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918006153 catalytic residue [active] 189918006154 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 189918006155 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 189918006156 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918006157 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 189918006158 AsnC family; Region: AsnC_trans_reg; pfam01037 189918006159 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 189918006160 thiamine monophosphate kinase; Provisional; Region: PRK05731 189918006161 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 189918006162 ATP binding site [chemical binding]; other site 189918006163 dimerization interface [polypeptide binding]; other site 189918006164 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 189918006165 ligand binding site [chemical binding]; other site 189918006166 active site 189918006167 UGI interface [polypeptide binding]; other site 189918006168 catalytic site [active] 189918006169 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 189918006170 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 189918006171 DAK2 domain; Region: Dak2; pfam02734 189918006172 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 189918006173 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 189918006174 generic binding surface II; other site 189918006175 ssDNA binding site; other site 189918006176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918006177 ATP binding site [chemical binding]; other site 189918006178 putative Mg++ binding site [ion binding]; other site 189918006179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918006180 nucleotide binding region [chemical binding]; other site 189918006181 ATP-binding site [chemical binding]; other site 189918006182 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 189918006183 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918006184 active site 189918006185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918006186 catalytic tetrad [active] 189918006187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918006188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918006189 active site 189918006190 catalytic tetrad [active] 189918006191 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918006192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918006193 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 189918006194 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 189918006195 catalytic residues [active] 189918006196 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 189918006197 putative active site [active] 189918006198 redox center [active] 189918006199 pyruvate carboxylase; Reviewed; Region: PRK12999 189918006200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918006201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918006202 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 189918006203 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 189918006204 active site 189918006205 catalytic residues [active] 189918006206 metal binding site [ion binding]; metal-binding site 189918006207 homodimer binding site [polypeptide binding]; other site 189918006208 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918006209 carboxyltransferase (CT) interaction site; other site 189918006210 biotinylation site [posttranslational modification]; other site 189918006211 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 189918006212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918006213 S-adenosylmethionine binding site [chemical binding]; other site 189918006214 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 189918006215 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 189918006216 active site 189918006217 (T/H)XGH motif; other site 189918006218 Hemerythrin-like domain; Region: Hr-like; cd12108 189918006219 Fe binding site [ion binding]; other site 189918006220 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 189918006221 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 189918006222 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 189918006223 ribonuclease III; Reviewed; Region: rnc; PRK00102 189918006224 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 189918006225 dimerization interface [polypeptide binding]; other site 189918006226 active site 189918006227 metal binding site [ion binding]; metal-binding site 189918006228 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 189918006229 dsRNA binding site [nucleotide binding]; other site 189918006230 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 189918006231 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 189918006232 DNA binding site [nucleotide binding] 189918006233 catalytic residue [active] 189918006234 H2TH interface [polypeptide binding]; other site 189918006235 putative catalytic residues [active] 189918006236 turnover-facilitating residue; other site 189918006237 intercalation triad [nucleotide binding]; other site 189918006238 8OG recognition residue [nucleotide binding]; other site 189918006239 putative reading head residues; other site 189918006240 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 189918006241 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 189918006242 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 189918006243 acylphosphatase; Provisional; Region: PRK14422 189918006244 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 189918006245 AAA domain; Region: AAA_23; pfam13476 189918006246 Walker A/P-loop; other site 189918006247 ATP binding site [chemical binding]; other site 189918006248 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 189918006249 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 189918006250 ABC transporter signature motif; other site 189918006251 Walker B; other site 189918006252 D-loop; other site 189918006253 H-loop/switch region; other site 189918006254 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 189918006255 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 189918006256 homotetramer interface [polypeptide binding]; other site 189918006257 FMN binding site [chemical binding]; other site 189918006258 homodimer contacts [polypeptide binding]; other site 189918006259 putative active site [active] 189918006260 putative substrate binding site [chemical binding]; other site 189918006261 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 189918006262 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 189918006263 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918006264 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 189918006265 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 189918006266 Nitrogen regulatory protein P-II; Region: P-II; smart00938 189918006267 PII uridylyl-transferase; Provisional; Region: PRK03381 189918006268 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 189918006269 metal binding triad; other site 189918006270 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 189918006271 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918006272 Zn2+ binding site [ion binding]; other site 189918006273 Mg2+ binding site [ion binding]; other site 189918006274 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 189918006275 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 189918006276 signal recognition particle protein; Provisional; Region: PRK10867 189918006277 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 189918006278 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 189918006279 P loop; other site 189918006280 GTP binding site [chemical binding]; other site 189918006281 Signal peptide binding domain; Region: SRP_SPB; pfam02978 189918006282 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 189918006283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918006284 active site 189918006285 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 189918006286 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 189918006287 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 189918006288 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 189918006289 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918006290 SnoaL-like domain; Region: SnoaL_3; pfam13474 189918006291 Methyltransferase domain; Region: Methyltransf_11; pfam08241 189918006292 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 189918006293 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 189918006294 hypothetical protein; Provisional; Region: PRK02821 189918006295 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 189918006296 G-X-X-G motif; other site 189918006297 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 189918006298 RimM N-terminal domain; Region: RimM; pfam01782 189918006299 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 189918006300 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 189918006301 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 189918006302 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 189918006303 Catalytic site [active] 189918006304 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 189918006305 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 189918006306 RNA/DNA hybrid binding site [nucleotide binding]; other site 189918006307 active site 189918006308 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 189918006309 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918006310 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918006311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918006312 UMP phosphatase; Provisional; Region: PRK10444 189918006313 active site 189918006314 motif I; other site 189918006315 motif II; other site 189918006316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918006317 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 189918006318 TPP-binding site [chemical binding]; other site 189918006319 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 189918006320 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 189918006321 PYR/PP interface [polypeptide binding]; other site 189918006322 dimer interface [polypeptide binding]; other site 189918006323 TPP binding site [chemical binding]; other site 189918006324 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189918006325 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 189918006326 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918006327 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 189918006328 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918006329 active site 189918006330 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918006331 catalytic triad [active] 189918006332 dimer interface [polypeptide binding]; other site 189918006333 AMP-binding enzyme; Region: AMP-binding; pfam00501 189918006334 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918006335 active site 189918006336 CoA binding site [chemical binding]; other site 189918006337 AMP binding site [chemical binding]; other site 189918006338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918006339 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 189918006340 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 189918006341 Walker A/P-loop; other site 189918006342 ATP binding site [chemical binding]; other site 189918006343 Q-loop/lid; other site 189918006344 ABC transporter signature motif; other site 189918006345 Walker B; other site 189918006346 D-loop; other site 189918006347 H-loop/switch region; other site 189918006348 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 189918006349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918006350 dimer interface [polypeptide binding]; other site 189918006351 conserved gate region; other site 189918006352 ABC-ATPase subunit interface; other site 189918006353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918006354 dimer interface [polypeptide binding]; other site 189918006355 conserved gate region; other site 189918006356 ABC-ATPase subunit interface; other site 189918006357 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 189918006358 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 189918006359 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 189918006360 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 189918006361 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 189918006362 hypothetical protein; Reviewed; Region: PRK12497 189918006363 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 189918006364 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 189918006365 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 189918006366 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 189918006367 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 189918006368 DNA protecting protein DprA; Region: dprA; TIGR00732 189918006369 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 189918006370 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 189918006371 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 189918006372 FAD binding pocket [chemical binding]; other site 189918006373 FAD binding motif [chemical binding]; other site 189918006374 phosphate binding motif [ion binding]; other site 189918006375 NAD binding pocket [chemical binding]; other site 189918006376 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 189918006377 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 189918006378 putative active site [active] 189918006379 putative substrate binding site [chemical binding]; other site 189918006380 putative FMN binding site [chemical binding]; other site 189918006381 putative catalytic residues [active] 189918006382 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 189918006383 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918006384 active site 189918006385 DNA binding site [nucleotide binding] 189918006386 Int/Topo IB signature motif; other site 189918006387 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189918006388 Peptidase family M23; Region: Peptidase_M23; pfam01551 189918006389 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 189918006390 rRNA interaction site [nucleotide binding]; other site 189918006391 S8 interaction site; other site 189918006392 putative laminin-1 binding site; other site 189918006393 elongation factor Ts; Provisional; Region: tsf; PRK09377 189918006394 UBA/TS-N domain; Region: UBA; pfam00627 189918006395 Elongation factor TS; Region: EF_TS; pfam00889 189918006396 Elongation factor TS; Region: EF_TS; pfam00889 189918006397 amidase; Provisional; Region: PRK07869 189918006398 Amidase; Region: Amidase; cl11426 189918006399 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 189918006400 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189918006401 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189918006402 Walker A/P-loop; other site 189918006403 ATP binding site [chemical binding]; other site 189918006404 Q-loop/lid; other site 189918006405 ABC transporter signature motif; other site 189918006406 Walker B; other site 189918006407 D-loop; other site 189918006408 H-loop/switch region; other site 189918006409 Amino acid permease; Region: AA_permease_2; pfam13520 189918006410 tyramine oxidase; Provisional; Region: tynA; PRK11504 189918006411 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 189918006412 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 189918006413 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 189918006414 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 189918006415 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 189918006416 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 189918006417 dimerization interface [polypeptide binding]; other site 189918006418 ligand binding site [chemical binding]; other site 189918006419 NADP binding site [chemical binding]; other site 189918006420 catalytic site [active] 189918006421 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 189918006422 putative nucleotide binding site [chemical binding]; other site 189918006423 uridine monophosphate binding site [chemical binding]; other site 189918006424 homohexameric interface [polypeptide binding]; other site 189918006425 ribosome recycling factor; Reviewed; Region: frr; PRK00083 189918006426 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 189918006427 hinge region; other site 189918006428 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 189918006429 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 189918006430 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 189918006431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918006432 FeS/SAM binding site; other site 189918006433 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918006434 SnoaL-like domain; Region: SnoaL_3; pfam13474 189918006435 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 189918006436 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 189918006437 NAD binding site [chemical binding]; other site 189918006438 catalytic residues [active] 189918006439 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 189918006440 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918006441 molybdopterin cofactor binding site; other site 189918006442 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 189918006443 putative molybdopterin cofactor binding site; other site 189918006444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918006445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918006446 Ecdysteroid kinase; Region: EcKinase; cl17738 189918006447 Phosphotransferase enzyme family; Region: APH; pfam01636 189918006448 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918006449 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918006450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918006451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918006452 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918006453 Cytochrome P450; Region: p450; cl12078 189918006454 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918006455 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918006456 YacP-like NYN domain; Region: NYN_YacP; cl01491 189918006457 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918006458 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 189918006459 Strictosidine synthase; Region: Str_synth; pfam03088 189918006460 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918006461 Cytochrome P450; Region: p450; cl12078 189918006462 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918006463 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918006464 NAD(P) binding site [chemical binding]; other site 189918006465 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 189918006466 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 189918006467 classical (c) SDRs; Region: SDR_c; cd05233 189918006468 NAD(P) binding site [chemical binding]; other site 189918006469 active site 189918006470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918006471 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918006472 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918006473 putative active site [active] 189918006474 putative substrate binding site [chemical binding]; other site 189918006475 ATP binding site [chemical binding]; other site 189918006476 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918006477 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918006478 hydrophobic ligand binding site; other site 189918006479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918006480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918006481 active site 189918006482 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918006483 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918006484 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918006485 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918006486 Domain of unknown function (DUF427); Region: DUF427; pfam04248 189918006487 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918006488 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918006489 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918006490 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189918006491 FAD binding domain; Region: FAD_binding_4; pfam01565 189918006492 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 189918006493 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 189918006494 DNA photolyase; Region: DNA_photolyase; pfam00875 189918006495 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 189918006496 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 189918006497 active site 189918006498 catalytic site [active] 189918006499 tetramer interface [polypeptide binding]; other site 189918006500 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 189918006501 Fasciclin domain; Region: Fasciclin; pfam02469 189918006502 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 189918006503 Fasciclin domain; Region: Fasciclin; pfam02469 189918006504 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 189918006505 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 189918006506 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 189918006507 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 189918006508 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 189918006509 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 189918006510 active site 189918006511 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 189918006512 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 189918006513 putative substrate binding region [chemical binding]; other site 189918006514 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 189918006515 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 189918006516 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 189918006517 Predicted acetyltransferase [General function prediction only]; Region: COG3393 189918006518 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 189918006519 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 189918006520 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 189918006521 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 189918006522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189918006523 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 189918006524 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918006525 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918006526 CoenzymeA binding site [chemical binding]; other site 189918006527 subunit interaction site [polypeptide binding]; other site 189918006528 PHB binding site; other site 189918006529 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 189918006530 active site 189918006531 cobyric acid synthase; Provisional; Region: PRK00784 189918006532 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918006533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918006534 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 189918006535 catalytic triad [active] 189918006536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918006537 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 189918006538 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918006539 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 189918006540 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 189918006541 active site 189918006542 dimer interface [polypeptide binding]; other site 189918006543 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 189918006544 Ligand Binding Site [chemical binding]; other site 189918006545 Molecular Tunnel; other site 189918006546 ethanolamine permease; Region: 2A0305; TIGR00908 189918006547 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 189918006548 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189918006549 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918006550 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 189918006551 Peptidase C26; Region: Peptidase_C26; pfam07722 189918006552 catalytic triad [active] 189918006553 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918006554 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918006555 NAD(P) binding site [chemical binding]; other site 189918006556 catalytic residues [active] 189918006557 short chain dehydrogenase; Provisional; Region: PRK06057 189918006558 classical (c) SDRs; Region: SDR_c; cd05233 189918006559 NAD(P) binding site [chemical binding]; other site 189918006560 active site 189918006561 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918006562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918006563 DNA-binding site [nucleotide binding]; DNA binding site 189918006564 FCD domain; Region: FCD; pfam07729 189918006565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918006566 dimerization interface [polypeptide binding]; other site 189918006567 putative DNA binding site [nucleotide binding]; other site 189918006568 putative Zn2+ binding site [ion binding]; other site 189918006569 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 189918006570 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 189918006571 PDGLE domain; Region: PDGLE; pfam13190 189918006572 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 189918006573 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918006574 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 189918006575 Walker A/P-loop; other site 189918006576 ATP binding site [chemical binding]; other site 189918006577 Q-loop/lid; other site 189918006578 ABC transporter signature motif; other site 189918006579 Walker B; other site 189918006580 D-loop; other site 189918006581 H-loop/switch region; other site 189918006582 mycothione reductase; Reviewed; Region: PRK07846 189918006583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918006584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918006585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 189918006586 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 189918006587 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918006588 malate:quinone oxidoreductase; Validated; Region: PRK05257 189918006589 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 189918006590 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 189918006591 Coenzyme A binding pocket [chemical binding]; other site 189918006592 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 189918006593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918006594 Walker A motif; other site 189918006595 ATP binding site [chemical binding]; other site 189918006596 Walker B motif; other site 189918006597 arginine finger; other site 189918006598 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 189918006599 metal ion-dependent adhesion site (MIDAS); other site 189918006600 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 189918006601 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 189918006602 Walker A motif; other site 189918006603 homodimer interface [polypeptide binding]; other site 189918006604 ATP binding site [chemical binding]; other site 189918006605 hydroxycobalamin binding site [chemical binding]; other site 189918006606 Walker B motif; other site 189918006607 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 189918006608 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 189918006609 catalytic triad [active] 189918006610 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 189918006611 siroheme synthase; Provisional; Region: cysG; PRK10637 189918006612 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 189918006613 homodimer interface [polypeptide binding]; other site 189918006614 active site 189918006615 SAM binding site [chemical binding]; other site 189918006616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918006617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918006618 putative substrate translocation pore; other site 189918006619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918006620 prolyl-tRNA synthetase; Provisional; Region: PRK09194 189918006621 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 189918006622 dimer interface [polypeptide binding]; other site 189918006623 motif 1; other site 189918006624 active site 189918006625 motif 2; other site 189918006626 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 189918006627 putative deacylase active site [active] 189918006628 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189918006629 active site 189918006630 motif 3; other site 189918006631 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 189918006632 anticodon binding site; other site 189918006633 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 189918006634 dinuclear metal binding motif [ion binding]; other site 189918006635 ribosome maturation protein RimP; Reviewed; Region: PRK00092 189918006636 Sm and related proteins; Region: Sm_like; cl00259 189918006637 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 189918006638 putative oligomer interface [polypeptide binding]; other site 189918006639 putative RNA binding site [nucleotide binding]; other site 189918006640 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 189918006641 NusA N-terminal domain; Region: NusA_N; pfam08529 189918006642 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 189918006643 RNA binding site [nucleotide binding]; other site 189918006644 homodimer interface [polypeptide binding]; other site 189918006645 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 189918006646 G-X-X-G motif; other site 189918006647 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 189918006648 G-X-X-G motif; other site 189918006649 Protein of unknown function (DUF448); Region: DUF448; pfam04296 189918006650 putative RNA binding cleft [nucleotide binding]; other site 189918006651 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 189918006652 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 189918006653 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 189918006654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 189918006655 G1 box; other site 189918006656 putative GEF interaction site [polypeptide binding]; other site 189918006657 GTP/Mg2+ binding site [chemical binding]; other site 189918006658 Switch I region; other site 189918006659 G2 box; other site 189918006660 G3 box; other site 189918006661 Switch II region; other site 189918006662 G4 box; other site 189918006663 G5 box; other site 189918006664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 189918006665 Translation-initiation factor 2; Region: IF-2; pfam11987 189918006666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 189918006667 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 189918006668 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 189918006669 DHH family; Region: DHH; pfam01368 189918006670 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 189918006671 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 189918006672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918006673 S-adenosylmethionine binding site [chemical binding]; other site 189918006674 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 189918006675 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918006676 DNA binding residues [nucleotide binding] 189918006677 dimer interface [polypeptide binding]; other site 189918006678 enoyl-CoA hydratase; Provisional; Region: PRK06190 189918006679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918006680 substrate binding site [chemical binding]; other site 189918006681 oxyanion hole (OAH) forming residues; other site 189918006682 trimer interface [polypeptide binding]; other site 189918006683 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 189918006684 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 189918006685 Predicted acyl esterases [General function prediction only]; Region: COG2936 189918006686 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 189918006687 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 189918006688 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 189918006689 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 189918006690 active site 189918006691 metal binding site [ion binding]; metal-binding site 189918006692 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 189918006693 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 189918006694 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 189918006695 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 189918006696 RNA binding site [nucleotide binding]; other site 189918006697 active site 189918006698 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 189918006699 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 189918006700 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 189918006701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918006702 putative DNA binding site [nucleotide binding]; other site 189918006703 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 189918006704 FeoA domain; Region: FeoA; pfam04023 189918006705 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 189918006706 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 189918006707 active site 189918006708 Riboflavin kinase; Region: Flavokinase; pfam01687 189918006709 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 189918006710 16S/18S rRNA binding site [nucleotide binding]; other site 189918006711 S13e-L30e interaction site [polypeptide binding]; other site 189918006712 25S rRNA binding site [nucleotide binding]; other site 189918006713 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 189918006714 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 189918006715 oligomer interface [polypeptide binding]; other site 189918006716 RNA binding site [nucleotide binding]; other site 189918006717 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 189918006718 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 189918006719 RNase E interface [polypeptide binding]; other site 189918006720 trimer interface [polypeptide binding]; other site 189918006721 active site 189918006722 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 189918006723 putative nucleic acid binding region [nucleotide binding]; other site 189918006724 G-X-X-G motif; other site 189918006725 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 189918006726 RNA binding site [nucleotide binding]; other site 189918006727 domain interface; other site 189918006728 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 189918006729 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 189918006730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 189918006731 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 189918006732 hypothetical protein; Provisional; Region: PRK01842 189918006733 SEC-C motif; Region: SEC-C; pfam02810 189918006734 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 189918006735 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 189918006736 hexamer interface [polypeptide binding]; other site 189918006737 ligand binding site [chemical binding]; other site 189918006738 putative active site [active] 189918006739 NAD(P) binding site [chemical binding]; other site 189918006740 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 189918006741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918006742 putative DNA binding site [nucleotide binding]; other site 189918006743 putative Zn2+ binding site [ion binding]; other site 189918006744 AsnC family; Region: AsnC_trans_reg; pfam01037 189918006745 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918006746 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918006747 active site 189918006748 dihydrodipicolinate reductase; Provisional; Region: PRK00048 189918006749 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918006750 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 189918006751 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 189918006752 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189918006753 Dienelactone hydrolase family; Region: DLH; pfam01738 189918006754 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 189918006755 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 189918006756 thymidylate synthase; Reviewed; Region: thyA; PRK01827 189918006757 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 189918006758 dimerization interface [polypeptide binding]; other site 189918006759 active site 189918006760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 189918006761 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 189918006762 folate binding site [chemical binding]; other site 189918006763 NADP+ binding site [chemical binding]; other site 189918006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 189918006765 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 189918006766 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 189918006767 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918006768 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 189918006769 dimer interface [polypeptide binding]; other site 189918006770 active site 189918006771 catalytic residue [active] 189918006772 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 189918006773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918006774 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 189918006775 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 189918006776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918006777 NAD(P) binding site [chemical binding]; other site 189918006778 active site 189918006779 Uncharacterized conserved protein [Function unknown]; Region: COG1359 189918006780 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 189918006781 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918006782 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 189918006783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918006784 Coenzyme A binding pocket [chemical binding]; other site 189918006785 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 189918006786 Competence-damaged protein; Region: CinA; pfam02464 189918006787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918006788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918006789 non-specific DNA binding site [nucleotide binding]; other site 189918006790 salt bridge; other site 189918006791 sequence-specific DNA binding site [nucleotide binding]; other site 189918006792 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 189918006793 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918006794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 189918006795 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 189918006796 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 189918006797 dimerization interface [polypeptide binding]; other site 189918006798 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 189918006799 ATP binding site [chemical binding]; other site 189918006800 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 189918006801 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 189918006802 HupF/HypC family; Region: HupF_HypC; pfam01455 189918006803 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 189918006804 Acylphosphatase; Region: Acylphosphatase; pfam00708 189918006805 HypF finger; Region: zf-HYPF; pfam07503 189918006806 HypF finger; Region: zf-HYPF; pfam07503 189918006807 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 189918006808 HupF/HypC family; Region: HupF_HypC; pfam01455 189918006809 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 189918006810 nickel binding site [ion binding]; other site 189918006811 NifU-like domain; Region: NifU; cl00484 189918006812 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918006813 iron-sulfur cluster [ion binding]; other site 189918006814 [2Fe-2S] cluster binding site [ion binding]; other site 189918006815 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 189918006816 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 189918006817 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 189918006818 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918006819 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 189918006820 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 189918006821 recombinase A; Provisional; Region: recA; PRK09354 189918006822 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 189918006823 hexamer interface [polypeptide binding]; other site 189918006824 Walker A motif; other site 189918006825 ATP binding site [chemical binding]; other site 189918006826 Walker B motif; other site 189918006827 recombination regulator RecX; Reviewed; Region: recX; PRK00117 189918006828 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918006829 MarR family; Region: MarR_2; pfam12802 189918006830 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918006831 TIGR03086 family protein; Region: TIGR03086 189918006832 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 189918006833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918006834 dimer interface [polypeptide binding]; other site 189918006835 conserved gate region; other site 189918006836 putative PBP binding loops; other site 189918006837 ABC-ATPase subunit interface; other site 189918006838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 189918006839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918006840 dimer interface [polypeptide binding]; other site 189918006841 conserved gate region; other site 189918006842 putative PBP binding loops; other site 189918006843 ABC-ATPase subunit interface; other site 189918006844 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 189918006845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918006846 substrate binding pocket [chemical binding]; other site 189918006847 membrane-bound complex binding site; other site 189918006848 hinge residues; other site 189918006849 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918006850 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 189918006851 Walker A/P-loop; other site 189918006852 ATP binding site [chemical binding]; other site 189918006853 Q-loop/lid; other site 189918006854 ABC transporter signature motif; other site 189918006855 Walker B; other site 189918006856 D-loop; other site 189918006857 H-loop/switch region; other site 189918006858 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 189918006859 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 189918006860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918006861 FeS/SAM binding site; other site 189918006862 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 189918006863 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 189918006864 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 189918006865 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 189918006866 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 189918006867 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 189918006868 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 189918006869 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 189918006870 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 189918006871 GTPases [General function prediction only]; Region: HflX; COG2262 189918006872 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 189918006873 HflX GTPase family; Region: HflX; cd01878 189918006874 G1 box; other site 189918006875 GTP/Mg2+ binding site [chemical binding]; other site 189918006876 Switch I region; other site 189918006877 G2 box; other site 189918006878 G3 box; other site 189918006879 Switch II region; other site 189918006880 G4 box; other site 189918006881 G5 box; other site 189918006882 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 189918006883 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 189918006884 ATP binding site [chemical binding]; other site 189918006885 Mg++ binding site [ion binding]; other site 189918006886 motif III; other site 189918006887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918006888 nucleotide binding region [chemical binding]; other site 189918006889 ATP-binding site [chemical binding]; other site 189918006890 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 189918006891 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 189918006892 molybdopterin cofactor binding site [chemical binding]; other site 189918006893 substrate binding site [chemical binding]; other site 189918006894 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 189918006895 molybdopterin cofactor binding site; other site 189918006896 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 189918006897 LGFP repeat; Region: LGFP; pfam08310 189918006898 LGFP repeat; Region: LGFP; pfam08310 189918006899 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 189918006900 LexA repressor; Validated; Region: PRK00215 189918006901 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 189918006902 Catalytic site [active] 189918006903 LysM domain; Region: LysM; pfam01476 189918006904 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 189918006905 ATP cone domain; Region: ATP-cone; pfam03477 189918006906 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 189918006907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918006908 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 189918006909 PAC2 family; Region: PAC2; pfam09754 189918006910 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 189918006911 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 189918006912 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 189918006913 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 189918006914 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 189918006915 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 189918006916 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 189918006917 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 189918006918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918006919 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189918006920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918006921 DNA binding residues [nucleotide binding] 189918006922 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 189918006923 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 189918006924 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 189918006925 Protein of unknown function (DUF952); Region: DUF952; pfam06108 189918006926 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 189918006927 homotrimer interaction site [polypeptide binding]; other site 189918006928 putative active site [active] 189918006929 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 189918006930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918006931 S-adenosylmethionine binding site [chemical binding]; other site 189918006932 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 189918006933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918006934 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189918006935 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918006936 DNA binding residues [nucleotide binding] 189918006937 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 189918006938 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918006939 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 189918006940 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 189918006941 active site 189918006942 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 189918006943 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 189918006944 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 189918006945 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 189918006946 trimer interface [polypeptide binding]; other site 189918006947 active site 189918006948 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 189918006949 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 189918006950 generic binding surface II; other site 189918006951 ssDNA binding site; other site 189918006952 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 189918006953 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 189918006954 TrkA-N domain; Region: TrkA_N; pfam02254 189918006955 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 189918006956 TrkA-N domain; Region: TrkA_N; pfam02254 189918006957 TrkA-C domain; Region: TrkA_C; pfam02080 189918006958 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918006959 TRAM domain; Region: TRAM; pfam01938 189918006960 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 189918006961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918006962 MarR family; Region: MarR_2; pfam12802 189918006963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189918006964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918006965 Walker A/P-loop; other site 189918006966 ATP binding site [chemical binding]; other site 189918006967 Q-loop/lid; other site 189918006968 ABC transporter signature motif; other site 189918006969 Walker B; other site 189918006970 D-loop; other site 189918006971 H-loop/switch region; other site 189918006972 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 189918006973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189918006974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918006975 Walker A/P-loop; other site 189918006976 ATP binding site [chemical binding]; other site 189918006977 Q-loop/lid; other site 189918006978 ABC transporter signature motif; other site 189918006979 Walker B; other site 189918006980 D-loop; other site 189918006981 H-loop/switch region; other site 189918006982 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 189918006983 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 189918006984 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 189918006985 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 189918006986 TPP-binding site; other site 189918006987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 189918006988 PYR/PP interface [polypeptide binding]; other site 189918006989 dimer interface [polypeptide binding]; other site 189918006990 TPP binding site [chemical binding]; other site 189918006991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189918006992 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 189918006993 putative active site [active] 189918006994 putative metal binding site [ion binding]; other site 189918006995 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 189918006996 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 189918006997 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 189918006998 catalytic site [active] 189918006999 putative active site [active] 189918007000 putative substrate binding site [chemical binding]; other site 189918007001 Helicase and RNase D C-terminal; Region: HRDC; smart00341 189918007002 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 189918007003 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 189918007004 substrate binding site [chemical binding]; other site 189918007005 active site 189918007006 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 189918007007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918007008 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 189918007009 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918007010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918007011 metal binding site [ion binding]; metal-binding site 189918007012 active site 189918007013 I-site; other site 189918007014 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189918007015 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 189918007016 SelR domain; Region: SelR; pfam01641 189918007017 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 189918007018 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918007019 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918007020 hypothetical protein; Provisional; Region: PRK14059 189918007021 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 189918007022 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 189918007023 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 189918007024 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 189918007025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918007026 Coenzyme A binding pocket [chemical binding]; other site 189918007027 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 189918007028 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 189918007029 DNA binding site [nucleotide binding] 189918007030 active site 189918007031 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189918007032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918007033 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918007034 DNA binding residues [nucleotide binding] 189918007035 Clp amino terminal domain; Region: Clp_N; pfam02861 189918007036 Clp amino terminal domain; Region: Clp_N; pfam02861 189918007037 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918007038 hydrophobic ligand binding site; other site 189918007039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918007040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918007041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918007042 Asp23 family; Region: Asp23; pfam03780 189918007043 Asp23 family; Region: Asp23; pfam03780 189918007044 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 189918007045 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 189918007046 GAF domain; Region: GAF; pfam01590 189918007047 GAF domain; Region: GAF_2; pfam13185 189918007048 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918007049 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 189918007050 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918007051 CoenzymeA binding site [chemical binding]; other site 189918007052 subunit interaction site [polypeptide binding]; other site 189918007053 PHB binding site; other site 189918007054 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 189918007055 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 189918007056 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 189918007057 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 189918007058 active site 189918007059 dimer interface [polypeptide binding]; other site 189918007060 motif 1; other site 189918007061 motif 2; other site 189918007062 motif 3; other site 189918007063 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 189918007064 anticodon binding site; other site 189918007065 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 189918007066 nucleotide binding site/active site [active] 189918007067 HIT family signature motif; other site 189918007068 catalytic residue [active] 189918007069 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 189918007070 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 189918007071 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 189918007072 putative acyl-acceptor binding pocket; other site 189918007073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918007074 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918007075 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189918007076 nudix motif; other site 189918007077 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 189918007078 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 189918007079 active site 189918007080 multimer interface [polypeptide binding]; other site 189918007081 acyl-CoA thioesterase II; Region: tesB; TIGR00189 189918007082 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918007083 active site 189918007084 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918007085 catalytic triad [active] 189918007086 dimer interface [polypeptide binding]; other site 189918007087 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 189918007088 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 189918007089 predicted active site [active] 189918007090 catalytic triad [active] 189918007091 hypothetical protein; Validated; Region: PRK00110 189918007092 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189918007093 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 189918007094 substrate binding pocket [chemical binding]; other site 189918007095 chain length determination region; other site 189918007096 substrate-Mg2+ binding site; other site 189918007097 catalytic residues [active] 189918007098 aspartate-rich region 1; other site 189918007099 active site lid residues [active] 189918007100 aspartate-rich region 2; other site 189918007101 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 189918007102 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 189918007103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918007104 classical (c) SDRs; Region: SDR_c; cd05233 189918007105 NAD(P) binding site [chemical binding]; other site 189918007106 active site 189918007107 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 189918007108 classical (c) SDRs; Region: SDR_c; cd05233 189918007109 NAD(P) binding site [chemical binding]; other site 189918007110 active site 189918007111 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 189918007112 agmatinase; Region: agmatinase; TIGR01230 189918007113 oligomer interface [polypeptide binding]; other site 189918007114 putative active site [active] 189918007115 Mn binding site [ion binding]; other site 189918007116 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 189918007117 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 189918007118 active site 189918007119 catalytic site [active] 189918007120 Zn binding site [ion binding]; other site 189918007121 tetramer interface [polypeptide binding]; other site 189918007122 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918007123 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918007124 iron-sulfur cluster [ion binding]; other site 189918007125 [2Fe-2S] cluster binding site [ion binding]; other site 189918007126 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918007127 hydrophobic ligand binding site; other site 189918007128 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918007129 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 189918007130 FMN-binding pocket [chemical binding]; other site 189918007131 flavin binding motif; other site 189918007132 phosphate binding motif [ion binding]; other site 189918007133 beta-alpha-beta structure motif; other site 189918007134 NAD binding pocket [chemical binding]; other site 189918007135 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918007136 catalytic loop [active] 189918007137 iron binding site [ion binding]; other site 189918007138 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 189918007139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918007140 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 189918007141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 189918007142 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189918007143 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 189918007144 active site 189918007145 putative DNA-binding cleft [nucleotide binding]; other site 189918007146 dimer interface [polypeptide binding]; other site 189918007147 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 189918007148 RuvA N terminal domain; Region: RuvA_N; pfam01330 189918007149 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 189918007150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918007151 Walker A motif; other site 189918007152 ATP binding site [chemical binding]; other site 189918007153 Walker B motif; other site 189918007154 arginine finger; other site 189918007155 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 189918007156 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 189918007157 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 189918007158 putative di-iron ligands [ion binding]; other site 189918007159 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 189918007160 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 189918007161 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918007162 FAD binding pocket [chemical binding]; other site 189918007163 FAD binding motif [chemical binding]; other site 189918007164 phosphate binding motif [ion binding]; other site 189918007165 beta-alpha-beta structure motif; other site 189918007166 NAD binding pocket [chemical binding]; other site 189918007167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918007168 catalytic loop [active] 189918007169 iron binding site [ion binding]; other site 189918007170 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189918007171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918007172 acyl-activating enzyme (AAE) consensus motif; other site 189918007173 AMP binding site [chemical binding]; other site 189918007174 active site 189918007175 CoA binding site [chemical binding]; other site 189918007176 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918007177 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 189918007178 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 189918007179 putative NAD(P) binding site [chemical binding]; other site 189918007180 active site 189918007181 putative substrate binding site [chemical binding]; other site 189918007182 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 189918007183 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 189918007184 tetrameric interface [polypeptide binding]; other site 189918007185 NAD binding site [chemical binding]; other site 189918007186 catalytic residues [active] 189918007187 substrate binding site [chemical binding]; other site 189918007188 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 189918007189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918007190 inhibitor-cofactor binding pocket; inhibition site 189918007191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918007192 catalytic residue [active] 189918007193 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 189918007194 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 189918007195 Protein export membrane protein; Region: SecD_SecF; cl14618 189918007196 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 189918007197 Protein export membrane protein; Region: SecD_SecF; pfam02355 189918007198 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 189918007199 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 189918007200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918007201 active site 189918007202 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 189918007203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918007204 Zn2+ binding site [ion binding]; other site 189918007205 Mg2+ binding site [ion binding]; other site 189918007206 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 189918007207 synthetase active site [active] 189918007208 NTP binding site [chemical binding]; other site 189918007209 metal binding site [ion binding]; metal-binding site 189918007210 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 189918007211 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 189918007212 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918007213 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918007214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918007215 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918007216 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 189918007217 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 189918007218 active site 189918007219 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 189918007220 active site 189918007221 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 189918007222 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 189918007223 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 189918007224 dimer interface [polypeptide binding]; other site 189918007225 motif 1; other site 189918007226 active site 189918007227 motif 2; other site 189918007228 motif 3; other site 189918007229 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 189918007230 anticodon binding site; other site 189918007231 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918007232 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 189918007233 putative NAD(P) binding site [chemical binding]; other site 189918007234 catalytic Zn binding site [ion binding]; other site 189918007235 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 189918007236 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 189918007237 Walker A/P-loop; other site 189918007238 ATP binding site [chemical binding]; other site 189918007239 Q-loop/lid; other site 189918007240 ABC transporter signature motif; other site 189918007241 Walker B; other site 189918007242 D-loop; other site 189918007243 H-loop/switch region; other site 189918007244 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 189918007245 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 189918007246 Walker A/P-loop; other site 189918007247 ATP binding site [chemical binding]; other site 189918007248 Q-loop/lid; other site 189918007249 ABC transporter signature motif; other site 189918007250 Walker B; other site 189918007251 D-loop; other site 189918007252 H-loop/switch region; other site 189918007253 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 189918007254 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 189918007255 TM-ABC transporter signature motif; other site 189918007256 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 189918007257 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 189918007258 TM-ABC transporter signature motif; other site 189918007259 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 189918007260 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 189918007261 putative ligand binding site [chemical binding]; other site 189918007262 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 189918007263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 189918007264 PYR/PP interface [polypeptide binding]; other site 189918007265 dimer interface [polypeptide binding]; other site 189918007266 TPP binding site [chemical binding]; other site 189918007267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 189918007268 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 189918007269 TPP-binding site; other site 189918007270 dimer interface [polypeptide binding]; other site 189918007271 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918007272 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 189918007273 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 189918007274 DNA-binding site [nucleotide binding]; DNA binding site 189918007275 RNA-binding motif; other site 189918007276 Radical SAM superfamily; Region: Radical_SAM; pfam04055 189918007277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918007278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918007279 active site 189918007280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918007281 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918007282 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918007283 active site 189918007284 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918007285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918007286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918007287 acyl-CoA thioesterase II; Region: tesB; TIGR00189 189918007288 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918007289 active site 189918007290 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918007291 catalytic triad [active] 189918007292 dimer interface [polypeptide binding]; other site 189918007293 DinB superfamily; Region: DinB_2; pfam12867 189918007294 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 189918007295 Predicted metalloprotease [General function prediction only]; Region: COG2321 189918007296 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 189918007297 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 189918007298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918007299 substrate binding pocket [chemical binding]; other site 189918007300 catalytic triad [active] 189918007301 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 189918007302 putative hydrophobic ligand binding site [chemical binding]; other site 189918007303 protein interface [polypeptide binding]; other site 189918007304 gate; other site 189918007305 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 189918007306 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 189918007307 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 189918007308 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 189918007309 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 189918007310 dimer interface [polypeptide binding]; other site 189918007311 anticodon binding site; other site 189918007312 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 189918007313 homodimer interface [polypeptide binding]; other site 189918007314 motif 1; other site 189918007315 active site 189918007316 motif 2; other site 189918007317 GAD domain; Region: GAD; pfam02938 189918007318 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189918007319 active site 189918007320 motif 3; other site 189918007321 Uncharacterized conserved protein [Function unknown]; Region: COG3349 189918007322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918007323 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 189918007324 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189918007325 substrate binding pocket [chemical binding]; other site 189918007326 chain length determination region; other site 189918007327 substrate-Mg2+ binding site; other site 189918007328 catalytic residues [active] 189918007329 aspartate-rich region 1; other site 189918007330 active site lid residues [active] 189918007331 aspartate-rich region 2; other site 189918007332 Predicted ATPase [General function prediction only]; Region: COG3899 189918007333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918007334 Walker A motif; other site 189918007335 ATP binding site [chemical binding]; other site 189918007336 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918007337 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189918007338 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918007339 cyclase homology domain; Region: CHD; cd07302 189918007340 nucleotidyl binding site; other site 189918007341 metal binding site [ion binding]; metal-binding site 189918007342 dimer interface [polypeptide binding]; other site 189918007343 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918007344 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 189918007345 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 189918007346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918007347 dimer interface [polypeptide binding]; other site 189918007348 active site 189918007349 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918007350 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 189918007351 Domain of unknown function (DUF389); Region: DUF389; cl00781 189918007352 Domain of unknown function (DUF389); Region: DUF389; pfam04087 189918007353 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 189918007354 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 189918007355 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 189918007356 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 189918007357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 189918007358 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 189918007359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 189918007360 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 189918007361 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 189918007362 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 189918007363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 189918007364 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 189918007365 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 189918007366 recombination factor protein RarA; Reviewed; Region: PRK13342 189918007367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918007368 Walker A motif; other site 189918007369 ATP binding site [chemical binding]; other site 189918007370 Walker B motif; other site 189918007371 arginine finger; other site 189918007372 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 189918007373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918007374 dimerization interface [polypeptide binding]; other site 189918007375 putative DNA binding site [nucleotide binding]; other site 189918007376 putative Zn2+ binding site [ion binding]; other site 189918007377 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 189918007378 putative hydrophobic ligand binding site [chemical binding]; other site 189918007379 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 189918007380 dimer interface [polypeptide binding]; other site 189918007381 active site 189918007382 product binding site; other site 189918007383 malonyl-CoA binding site [chemical binding]; other site 189918007384 Phospholipid methyltransferase; Region: PEMT; cl17370 189918007385 MMPL family; Region: MMPL; pfam03176 189918007386 MMPL family; Region: MMPL; pfam03176 189918007387 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 189918007388 putative hydrophobic ligand binding site [chemical binding]; other site 189918007389 gas vesicle synthesis-like protein; Reviewed; Region: PRK09368 189918007390 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 189918007391 Gas vesicle protein G; Region: GvpG; pfam05120 189918007392 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 189918007393 Gas vesicle protein; Region: Gas_vesicle; pfam00741 189918007394 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 189918007395 Gas vesicle protein; Region: Gas_vesicle; pfam00741 189918007396 Gas vesicle protein K; Region: GvpK; pfam05121 189918007397 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 189918007398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918007399 acyl-activating enzyme (AAE) consensus motif; other site 189918007400 AMP binding site [chemical binding]; other site 189918007401 active site 189918007402 CoA binding site [chemical binding]; other site 189918007403 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 189918007404 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 189918007405 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 189918007406 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 189918007407 motif 1; other site 189918007408 active site 189918007409 motif 2; other site 189918007410 motif 3; other site 189918007411 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 189918007412 DHHA1 domain; Region: DHHA1; pfam02272 189918007413 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 189918007414 YceG-like family; Region: YceG; pfam02618 189918007415 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 189918007416 dimerization interface [polypeptide binding]; other site 189918007417 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 189918007418 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 189918007419 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 189918007420 shikimate binding site; other site 189918007421 NAD(P) binding site [chemical binding]; other site 189918007422 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 189918007423 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 189918007424 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918007425 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 189918007426 NAD(P) binding site [chemical binding]; other site 189918007427 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 189918007428 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 189918007429 Tetramer interface [polypeptide binding]; other site 189918007430 active site 189918007431 FMN-binding site [chemical binding]; other site 189918007432 shikimate kinase; Reviewed; Region: aroK; PRK00131 189918007433 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 189918007434 ADP binding site [chemical binding]; other site 189918007435 magnesium binding site [ion binding]; other site 189918007436 putative shikimate binding site; other site 189918007437 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 189918007438 active site 189918007439 dimer interface [polypeptide binding]; other site 189918007440 metal binding site [ion binding]; metal-binding site 189918007441 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 189918007442 Dehydroquinase class II; Region: DHquinase_II; pfam01220 189918007443 trimer interface [polypeptide binding]; other site 189918007444 active site 189918007445 dimer interface [polypeptide binding]; other site 189918007446 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 189918007447 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 189918007448 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 189918007449 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 189918007450 active site 189918007451 elongation factor P; Validated; Region: PRK00529 189918007452 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 189918007453 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 189918007454 RNA binding site [nucleotide binding]; other site 189918007455 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 189918007456 RNA binding site [nucleotide binding]; other site 189918007457 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 189918007458 putative RNA binding site [nucleotide binding]; other site 189918007459 hypothetical protein; Provisional; Region: PRK07236 189918007460 hypothetical protein; Validated; Region: PRK05868 189918007461 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918007462 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918007463 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 189918007464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918007465 active site 189918007466 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 189918007467 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 189918007468 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 189918007469 dihydroorotase; Validated; Region: pyrC; PRK09357 189918007470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918007471 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 189918007472 active site 189918007473 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 189918007474 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 189918007475 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 189918007476 catalytic site [active] 189918007477 subunit interface [polypeptide binding]; other site 189918007478 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 189918007479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918007480 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918007481 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 189918007482 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918007483 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918007484 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 189918007485 IMP binding site; other site 189918007486 dimer interface [polypeptide binding]; other site 189918007487 interdomain contacts; other site 189918007488 partial ornithine binding site; other site 189918007489 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 189918007490 active site 189918007491 dimer interface [polypeptide binding]; other site 189918007492 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918007493 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 189918007494 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 189918007495 catalytic site [active] 189918007496 G-X2-G-X-G-K; other site 189918007497 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 189918007498 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 189918007499 Flavoprotein; Region: Flavoprotein; pfam02441 189918007500 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 189918007501 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 189918007502 S-adenosylmethionine synthetase; Validated; Region: PRK05250 189918007503 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 189918007504 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 189918007505 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918007506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918007507 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 189918007508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918007509 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 189918007510 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189918007511 putative NAD(P) binding site [chemical binding]; other site 189918007512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918007513 Predicted membrane protein [Function unknown]; Region: COG3714 189918007514 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 189918007515 primosome assembly protein PriA; Provisional; Region: PRK14873 189918007516 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 189918007517 LemA family; Region: LemA; cl00742 189918007518 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 189918007519 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 189918007520 putative active site [active] 189918007521 substrate binding site [chemical binding]; other site 189918007522 putative cosubstrate binding site; other site 189918007523 catalytic site [active] 189918007524 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 189918007525 substrate binding site [chemical binding]; other site 189918007526 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 189918007527 putative RNA binding site [nucleotide binding]; other site 189918007528 16S rRNA methyltransferase B; Provisional; Region: PRK14902 189918007529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918007530 S-adenosylmethionine binding site [chemical binding]; other site 189918007531 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 189918007532 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 189918007533 substrate binding site [chemical binding]; other site 189918007534 hexamer interface [polypeptide binding]; other site 189918007535 metal binding site [ion binding]; metal-binding site 189918007536 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 189918007537 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 189918007538 catalytic motif [active] 189918007539 Zn binding site [ion binding]; other site 189918007540 RibD C-terminal domain; Region: RibD_C; pfam01872 189918007541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918007542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918007543 putative substrate translocation pore; other site 189918007544 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 189918007545 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 189918007546 Lumazine binding domain; Region: Lum_binding; pfam00677 189918007547 Lumazine binding domain; Region: Lum_binding; pfam00677 189918007548 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 189918007549 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 189918007550 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 189918007551 dimerization interface [polypeptide binding]; other site 189918007552 active site 189918007553 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 189918007554 homopentamer interface [polypeptide binding]; other site 189918007555 active site 189918007556 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 189918007557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918007558 Coenzyme A binding pocket [chemical binding]; other site 189918007559 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 189918007560 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 189918007561 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 189918007562 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 189918007563 GIY-YIG motif/motif A; other site 189918007564 active site 189918007565 catalytic site [active] 189918007566 putative DNA binding site [nucleotide binding]; other site 189918007567 metal binding site [ion binding]; metal-binding site 189918007568 UvrB/uvrC motif; Region: UVR; pfam02151 189918007569 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 189918007570 minor groove reading motif; other site 189918007571 Helix-hairpin-helix motif; Region: HHH; pfam00633 189918007572 helix-hairpin-helix signature motif; other site 189918007573 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 189918007574 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 189918007575 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 189918007576 phosphate binding site [ion binding]; other site 189918007577 putative substrate binding pocket [chemical binding]; other site 189918007578 dimer interface [polypeptide binding]; other site 189918007579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 189918007580 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 189918007581 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 189918007582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918007583 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918007584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918007585 substrate binding pocket [chemical binding]; other site 189918007586 membrane-bound complex binding site; other site 189918007587 hinge residues; other site 189918007588 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 189918007589 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 189918007590 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 189918007591 Phosphoglycerate kinase; Region: PGK; pfam00162 189918007592 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 189918007593 substrate binding site [chemical binding]; other site 189918007594 hinge regions; other site 189918007595 ADP binding site [chemical binding]; other site 189918007596 catalytic site [active] 189918007597 triosephosphate isomerase; Provisional; Region: PRK14567 189918007598 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 189918007599 substrate binding site [chemical binding]; other site 189918007600 dimer interface [polypeptide binding]; other site 189918007601 catalytic triad [active] 189918007602 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 189918007603 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 189918007604 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 189918007605 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 189918007606 putative active site [active] 189918007607 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 189918007608 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 189918007609 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 189918007610 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 189918007611 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 189918007612 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 189918007613 putative active site [active] 189918007614 transaldolase; Provisional; Region: PRK03903 189918007615 catalytic residue [active] 189918007616 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 189918007617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 189918007618 TPP-binding site [chemical binding]; other site 189918007619 dimer interface [polypeptide binding]; other site 189918007620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 189918007621 PYR/PP interface [polypeptide binding]; other site 189918007622 dimer interface [polypeptide binding]; other site 189918007623 TPP binding site [chemical binding]; other site 189918007624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189918007625 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 189918007626 UbiA prenyltransferase family; Region: UbiA; pfam01040 189918007627 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 189918007628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918007629 Walker A/P-loop; other site 189918007630 ATP binding site [chemical binding]; other site 189918007631 Q-loop/lid; other site 189918007632 ABC transporter signature motif; other site 189918007633 Walker B; other site 189918007634 D-loop; other site 189918007635 H-loop/switch region; other site 189918007636 TOBE domain; Region: TOBE_2; pfam08402 189918007637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 189918007638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918007639 dimer interface [polypeptide binding]; other site 189918007640 conserved gate region; other site 189918007641 putative PBP binding loops; other site 189918007642 ABC-ATPase subunit interface; other site 189918007643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918007644 dimer interface [polypeptide binding]; other site 189918007645 conserved gate region; other site 189918007646 putative PBP binding loops; other site 189918007647 ABC-ATPase subunit interface; other site 189918007648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 189918007649 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 189918007650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918007651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918007652 NAD(P) binding site [chemical binding]; other site 189918007653 active site 189918007654 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 189918007655 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 189918007656 N- and C-terminal domain interface [polypeptide binding]; other site 189918007657 putative active site [active] 189918007658 MgATP binding site [chemical binding]; other site 189918007659 catalytic site [active] 189918007660 metal binding site [ion binding]; metal-binding site 189918007661 putative xylulose binding site [chemical binding]; other site 189918007662 putative homodimer interface [polypeptide binding]; other site 189918007663 BtpA family; Region: BtpA; cl00440 189918007664 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 189918007665 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 189918007666 active site 189918007667 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 189918007668 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 189918007669 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 189918007670 hypothetical protein; Provisional; Region: PRK09256 189918007671 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 189918007672 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 189918007673 NADP binding site [chemical binding]; other site 189918007674 dimer interface [polypeptide binding]; other site 189918007675 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 189918007676 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 189918007677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918007678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918007679 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918007680 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189918007681 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918007682 Walker A/P-loop; other site 189918007683 ATP binding site [chemical binding]; other site 189918007684 Q-loop/lid; other site 189918007685 ABC transporter signature motif; other site 189918007686 Walker B; other site 189918007687 D-loop; other site 189918007688 H-loop/switch region; other site 189918007689 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 189918007690 Predicted transcriptional regulator [Transcription]; Region: COG2345 189918007691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918007692 dimerization interface [polypeptide binding]; other site 189918007693 putative DNA binding site [nucleotide binding]; other site 189918007694 putative Zn2+ binding site [ion binding]; other site 189918007695 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 189918007696 FeS assembly protein SufB; Region: sufB; TIGR01980 189918007697 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 189918007698 FeS assembly protein SufD; Region: sufD; TIGR01981 189918007699 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 189918007700 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 189918007701 Walker A/P-loop; other site 189918007702 ATP binding site [chemical binding]; other site 189918007703 Q-loop/lid; other site 189918007704 ABC transporter signature motif; other site 189918007705 Walker B; other site 189918007706 D-loop; other site 189918007707 H-loop/switch region; other site 189918007708 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 189918007709 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 189918007710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918007711 catalytic residue [active] 189918007712 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 189918007713 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 189918007714 trimerization site [polypeptide binding]; other site 189918007715 active site 189918007716 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 189918007717 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 189918007718 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189918007719 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189918007720 catalytic residues [active] 189918007721 enoyl-CoA hydratase; Provisional; Region: PRK05864 189918007722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918007723 substrate binding site [chemical binding]; other site 189918007724 oxyanion hole (OAH) forming residues; other site 189918007725 trimer interface [polypeptide binding]; other site 189918007726 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189918007727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918007728 Walker A/P-loop; other site 189918007729 ATP binding site [chemical binding]; other site 189918007730 Q-loop/lid; other site 189918007731 ABC transporter signature motif; other site 189918007732 Walker B; other site 189918007733 D-loop; other site 189918007734 H-loop/switch region; other site 189918007735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918007736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918007737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918007738 aconitate hydratase; Validated; Region: PRK09277 189918007739 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 189918007740 substrate binding site [chemical binding]; other site 189918007741 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 189918007742 ligand binding site [chemical binding]; other site 189918007743 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 189918007744 substrate binding site [chemical binding]; other site 189918007745 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918007746 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918007747 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918007748 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918007749 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918007750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918007751 Walker A motif; other site 189918007752 ATP binding site [chemical binding]; other site 189918007753 Walker B motif; other site 189918007754 arginine finger; other site 189918007755 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 189918007756 Protein of unknown function DUF58; Region: DUF58; pfam01882 189918007757 hypothetical protein; Provisional; Region: PRK13685 189918007758 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 189918007759 metal ion-dependent adhesion site (MIDAS); other site 189918007760 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 189918007761 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 189918007762 NAD(P) binding site [chemical binding]; other site 189918007763 homotetramer interface [polypeptide binding]; other site 189918007764 homodimer interface [polypeptide binding]; other site 189918007765 active site 189918007766 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 189918007767 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 189918007768 NAD binding site [chemical binding]; other site 189918007769 homotetramer interface [polypeptide binding]; other site 189918007770 homodimer interface [polypeptide binding]; other site 189918007771 substrate binding site [chemical binding]; other site 189918007772 active site 189918007773 ferrochelatase; Reviewed; Region: hemH; PRK00035 189918007774 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 189918007775 C-terminal domain interface [polypeptide binding]; other site 189918007776 active site 189918007777 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 189918007778 active site 189918007779 N-terminal domain interface [polypeptide binding]; other site 189918007780 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918007781 hydroxyglutarate oxidase; Provisional; Region: PRK11728 189918007782 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 189918007783 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 189918007784 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 189918007785 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 189918007786 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 189918007787 hydroxyglutarate oxidase; Provisional; Region: PRK11728 189918007788 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918007789 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918007790 [2Fe-2S] cluster binding site [ion binding]; other site 189918007791 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918007792 hydrophobic ligand binding site; other site 189918007793 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 189918007794 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918007795 tetramerization interface [polypeptide binding]; other site 189918007796 NAD(P) binding site [chemical binding]; other site 189918007797 catalytic residues [active] 189918007798 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 189918007799 choline dehydrogenase; Validated; Region: PRK02106 189918007800 lycopene cyclase; Region: lycopene_cycl; TIGR01789 189918007801 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189918007802 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 189918007803 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189918007804 ligand binding site [chemical binding]; other site 189918007805 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 189918007806 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 189918007807 metal binding triad; other site 189918007808 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 189918007809 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918007810 Bacterial transcriptional regulator; Region: IclR; pfam01614 189918007811 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 189918007812 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918007813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918007814 active site 189918007815 Predicted transcriptional regulator [Transcription]; Region: COG2378 189918007816 WYL domain; Region: WYL; pfam13280 189918007817 Predicted transcriptional regulator [Transcription]; Region: COG2378 189918007818 WYL domain; Region: WYL; pfam13280 189918007819 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 189918007820 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 189918007821 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 189918007822 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 189918007823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918007824 ATP binding site [chemical binding]; other site 189918007825 putative Mg++ binding site [ion binding]; other site 189918007826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918007827 nucleotide binding region [chemical binding]; other site 189918007828 ATP-binding site [chemical binding]; other site 189918007829 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 189918007830 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 189918007831 5'-3' exonuclease; Region: 53EXOc; smart00475 189918007832 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 189918007833 active site 189918007834 metal binding site 1 [ion binding]; metal-binding site 189918007835 putative 5' ssDNA interaction site; other site 189918007836 metal binding site 3; metal-binding site 189918007837 metal binding site 2 [ion binding]; metal-binding site 189918007838 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 189918007839 putative DNA binding site [nucleotide binding]; other site 189918007840 putative metal binding site [ion binding]; other site 189918007841 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 189918007842 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 189918007843 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 189918007844 active site 189918007845 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918007846 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918007848 NAD(P) binding site [chemical binding]; other site 189918007849 active site 189918007850 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 189918007851 active site 189918007852 putative homodimer interface [polypeptide binding]; other site 189918007853 SAM binding site [chemical binding]; other site 189918007854 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 189918007855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918007856 S-adenosylmethionine binding site [chemical binding]; other site 189918007857 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 189918007858 active site 189918007859 SAM binding site [chemical binding]; other site 189918007860 homodimer interface [polypeptide binding]; other site 189918007861 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 189918007862 Phosphotransferase enzyme family; Region: APH; pfam01636 189918007863 Ecdysteroid kinase; Region: EcKinase; cl17738 189918007864 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 189918007865 active site 189918007866 SAM binding site [chemical binding]; other site 189918007867 homodimer interface [polypeptide binding]; other site 189918007868 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 189918007869 active site 189918007870 SAM binding site [chemical binding]; other site 189918007871 homodimer interface [polypeptide binding]; other site 189918007872 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 189918007873 Precorrin-8X methylmutase; Region: CbiC; pfam02570 189918007874 precorrin-3B synthase; Region: CobG; TIGR02435 189918007875 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918007876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918007877 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189918007878 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189918007879 ligand binding site [chemical binding]; other site 189918007880 flexible hinge region; other site 189918007881 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 189918007882 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 189918007883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918007884 ABC-ATPase subunit interface; other site 189918007885 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 189918007886 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 189918007887 Walker A/P-loop; other site 189918007888 ATP binding site [chemical binding]; other site 189918007889 Q-loop/lid; other site 189918007890 ABC transporter signature motif; other site 189918007891 Walker B; other site 189918007892 D-loop; other site 189918007893 H-loop/switch region; other site 189918007894 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 189918007895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918007896 putative PBP binding loops; other site 189918007897 dimer interface [polypeptide binding]; other site 189918007898 ABC-ATPase subunit interface; other site 189918007899 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 189918007900 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 189918007901 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 189918007902 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 189918007903 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 189918007904 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 189918007905 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189918007906 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 189918007907 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 189918007908 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 189918007909 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918007910 active site 189918007911 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 189918007912 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 189918007913 putative active site [active] 189918007914 catalytic triad [active] 189918007915 putative dimer interface [polypeptide binding]; other site 189918007916 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 189918007917 Ligand binding site; other site 189918007918 Putative Catalytic site; other site 189918007919 DXD motif; other site 189918007920 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 189918007921 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 189918007922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918007923 ATP binding site [chemical binding]; other site 189918007924 putative Mg++ binding site [ion binding]; other site 189918007925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918007926 nucleotide binding region [chemical binding]; other site 189918007927 ATP-binding site [chemical binding]; other site 189918007928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918007929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918007930 DNA binding site [nucleotide binding] 189918007931 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918007932 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 189918007933 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918007934 substrate binding pocket [chemical binding]; other site 189918007935 catalytic triad [active] 189918007936 Ecdysteroid kinase; Region: EcKinase; cl17738 189918007937 Phosphotransferase enzyme family; Region: APH; pfam01636 189918007938 hypothetical protein; Provisional; Region: PRK02237 189918007939 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 189918007940 RDD family; Region: RDD; pfam06271 189918007941 Predicted membrane protein [Function unknown]; Region: COG2259 189918007942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918007943 D-xylulose kinase; Region: XylB; TIGR01312 189918007944 nucleotide binding site [chemical binding]; other site 189918007945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918007946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918007947 active site 189918007948 Transcriptional regulators [Transcription]; Region: GntR; COG1802 189918007949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918007950 DNA-binding site [nucleotide binding]; DNA binding site 189918007951 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 189918007952 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 189918007953 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 189918007954 active site 189918007955 non-prolyl cis peptide bond; other site 189918007956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918007957 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189918007958 active site residue [active] 189918007959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189918007960 active site residue [active] 189918007961 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 189918007962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918007963 dimer interface [polypeptide binding]; other site 189918007964 conserved gate region; other site 189918007965 putative PBP binding loops; other site 189918007966 ABC-ATPase subunit interface; other site 189918007967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 189918007968 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 189918007969 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 189918007970 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 189918007971 Walker A/P-loop; other site 189918007972 ATP binding site [chemical binding]; other site 189918007973 Q-loop/lid; other site 189918007974 ABC transporter signature motif; other site 189918007975 Walker B; other site 189918007976 D-loop; other site 189918007977 H-loop/switch region; other site 189918007978 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 189918007979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189918007980 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918007981 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 189918007982 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 189918007983 N- and C-terminal domain interface [polypeptide binding]; other site 189918007984 putative active site [active] 189918007985 MgATP binding site [chemical binding]; other site 189918007986 catalytic site [active] 189918007987 metal binding site [ion binding]; metal-binding site 189918007988 putative xylulose binding site [chemical binding]; other site 189918007989 putative homodimer interface [polypeptide binding]; other site 189918007990 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 189918007991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918007992 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918007993 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918007994 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918007995 Cytochrome P450; Region: p450; cl12078 189918007996 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918007997 mce related protein; Region: MCE; pfam02470 189918007998 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918007999 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918008000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008001 short chain dehydrogenase; Provisional; Region: PRK07791 189918008002 NAD(P) binding site [chemical binding]; other site 189918008003 active site 189918008004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918008005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918008006 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 189918008007 metal ion-dependent adhesion site (MIDAS); other site 189918008008 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918008009 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 189918008010 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 189918008011 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 189918008012 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 189918008013 ligand binding site [chemical binding]; other site 189918008014 short chain dehydrogenase; Provisional; Region: PRK06179 189918008015 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 189918008016 NADP binding site [chemical binding]; other site 189918008017 active site 189918008018 steroid binding site; other site 189918008019 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 189918008020 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 189918008021 NAD binding site [chemical binding]; other site 189918008022 catalytic residues [active] 189918008023 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918008024 Cytochrome P450; Region: p450; cl12078 189918008025 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918008026 Cytochrome P450; Region: p450; cl12078 189918008027 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918008028 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918008029 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 189918008030 Winged helix-turn helix; Region: HTH_29; pfam13551 189918008031 Integrase core domain; Region: rve; pfam00665 189918008032 Integrase core domain; Region: rve_3; pfam13683 189918008033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918008034 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918008035 putative acyl-acceptor binding pocket; other site 189918008036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008040 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918008041 classical (c) SDRs; Region: SDR_c; cd05233 189918008042 NAD(P) binding site [chemical binding]; other site 189918008043 active site 189918008044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008045 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 189918008046 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918008047 Cytochrome P450; Region: p450; cl12078 189918008048 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 189918008049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918008050 DNA binding residues [nucleotide binding] 189918008051 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 189918008052 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918008053 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918008054 NAD(P) binding site [chemical binding]; other site 189918008055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 189918008056 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 189918008057 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 189918008058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008059 dimer interface [polypeptide binding]; other site 189918008060 conserved gate region; other site 189918008061 putative PBP binding loops; other site 189918008062 ABC-ATPase subunit interface; other site 189918008063 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 189918008064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008065 dimer interface [polypeptide binding]; other site 189918008066 conserved gate region; other site 189918008067 putative PBP binding loops; other site 189918008068 ABC-ATPase subunit interface; other site 189918008069 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 189918008070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008071 Walker A/P-loop; other site 189918008072 ATP binding site [chemical binding]; other site 189918008073 Q-loop/lid; other site 189918008074 ABC transporter signature motif; other site 189918008075 Walker B; other site 189918008076 D-loop; other site 189918008077 H-loop/switch region; other site 189918008078 TOBE domain; Region: TOBE_2; pfam08402 189918008079 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 189918008080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008081 Walker A/P-loop; other site 189918008082 ATP binding site [chemical binding]; other site 189918008083 Q-loop/lid; other site 189918008084 ABC transporter signature motif; other site 189918008085 Walker B; other site 189918008086 D-loop; other site 189918008087 H-loop/switch region; other site 189918008088 dihydroxyacetone kinase; Provisional; Region: PRK14479 189918008089 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 189918008090 DAK2 domain; Region: Dak2; pfam02734 189918008091 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 189918008092 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 189918008093 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 189918008094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008095 dimer interface [polypeptide binding]; other site 189918008096 conserved gate region; other site 189918008097 putative PBP binding loops; other site 189918008098 ABC-ATPase subunit interface; other site 189918008099 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 189918008100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008101 dimer interface [polypeptide binding]; other site 189918008102 conserved gate region; other site 189918008103 putative PBP binding loops; other site 189918008104 ABC-ATPase subunit interface; other site 189918008105 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 189918008106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 189918008107 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 189918008108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008109 Walker A/P-loop; other site 189918008110 ATP binding site [chemical binding]; other site 189918008111 Q-loop/lid; other site 189918008112 ABC transporter signature motif; other site 189918008113 Walker B; other site 189918008114 D-loop; other site 189918008115 H-loop/switch region; other site 189918008116 TOBE domain; Region: TOBE_2; pfam08402 189918008117 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918008118 hydrophobic ligand binding site; other site 189918008119 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 189918008120 TspO/MBR family; Region: TspO_MBR; pfam03073 189918008121 tartrate dehydrogenase; Provisional; Region: PRK08194 189918008122 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 189918008123 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 189918008124 tartrate dehydrogenase; Provisional; Region: PRK08194 189918008125 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 189918008126 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 189918008127 transmembrane helices; other site 189918008128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918008129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918008130 putative DNA binding site [nucleotide binding]; other site 189918008131 putative Zn2+ binding site [ion binding]; other site 189918008132 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 189918008133 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918008134 Ferredoxin [Energy production and conversion]; Region: COG1146 189918008135 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 189918008136 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918008137 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 189918008138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008139 Walker A/P-loop; other site 189918008140 ATP binding site [chemical binding]; other site 189918008141 Q-loop/lid; other site 189918008142 ABC transporter signature motif; other site 189918008143 Walker B; other site 189918008144 D-loop; other site 189918008145 H-loop/switch region; other site 189918008146 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 189918008147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008148 dimer interface [polypeptide binding]; other site 189918008149 conserved gate region; other site 189918008150 putative PBP binding loops; other site 189918008151 ABC-ATPase subunit interface; other site 189918008152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 189918008153 substrate binding pocket [chemical binding]; other site 189918008154 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 189918008155 membrane-bound complex binding site; other site 189918008156 hinge residues; other site 189918008157 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 189918008158 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 189918008159 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918008160 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918008161 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 189918008162 active site 1 [active] 189918008163 dimer interface [polypeptide binding]; other site 189918008164 hexamer interface [polypeptide binding]; other site 189918008165 active site 2 [active] 189918008166 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 189918008167 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 189918008168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918008169 catalytic residue [active] 189918008170 Transposase; Region: HTH_Tnp_1; cl17663 189918008171 putative transposase OrfB; Reviewed; Region: PHA02517 189918008172 HTH-like domain; Region: HTH_21; pfam13276 189918008173 Integrase core domain; Region: rve; pfam00665 189918008174 Integrase core domain; Region: rve_3; cl15866 189918008175 AAA domain; Region: AAA_23; pfam13476 189918008176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008177 ABC transporter signature motif; other site 189918008178 Walker B; other site 189918008179 D-loop; other site 189918008180 H-loop/switch region; other site 189918008181 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 189918008182 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918008183 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 189918008184 active site 189918008185 DNA binding site [nucleotide binding] 189918008186 Int/Topo IB signature motif; other site 189918008187 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 189918008188 YaeQ protein; Region: YaeQ; pfam07152 189918008189 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918008190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918008191 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 189918008192 Flavin binding site [chemical binding]; other site 189918008193 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 189918008194 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 189918008195 AMP-binding domain protein; Validated; Region: PRK07529 189918008196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918008197 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 189918008198 acyl-activating enzyme (AAE) consensus motif; other site 189918008199 putative AMP binding site [chemical binding]; other site 189918008200 putative active site [active] 189918008201 putative CoA binding site [chemical binding]; other site 189918008202 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918008203 CoenzymeA binding site [chemical binding]; other site 189918008204 subunit interaction site [polypeptide binding]; other site 189918008205 PHB binding site; other site 189918008206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918008207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918008208 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 189918008209 putative substrate binding pocket [chemical binding]; other site 189918008210 dimerization interface [polypeptide binding]; other site 189918008211 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 189918008212 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 189918008213 tetramer interface [polypeptide binding]; other site 189918008214 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 189918008215 active site 189918008216 metal binding site [ion binding]; metal-binding site 189918008217 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 189918008218 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 189918008219 NAD binding site [chemical binding]; other site 189918008220 catalytic residues [active] 189918008221 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 189918008222 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 189918008223 dimer interface [polypeptide binding]; other site 189918008224 active site 189918008225 catalytic residue [active] 189918008226 hypothetical protein; Provisional; Region: PRK12764 189918008227 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 189918008228 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 189918008229 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 189918008230 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 189918008231 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 189918008232 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 189918008233 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 189918008234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918008235 active site 189918008236 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 189918008237 short chain dehydrogenase; Provisional; Region: PRK06180 189918008238 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 189918008239 NADP binding site [chemical binding]; other site 189918008240 active site 189918008241 steroid binding site; other site 189918008242 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 189918008243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918008244 DNA binding residues [nucleotide binding] 189918008245 putative dimer interface [polypeptide binding]; other site 189918008246 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189918008247 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918008248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918008249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918008250 salt bridge; other site 189918008251 non-specific DNA binding site [nucleotide binding]; other site 189918008252 sequence-specific DNA binding site [nucleotide binding]; other site 189918008253 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 189918008254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008255 NAD(P) binding site [chemical binding]; other site 189918008256 active site 189918008257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008259 aldose dehydrogenase; Validated; Region: PRK06398 189918008260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008261 NAD(P) binding site [chemical binding]; other site 189918008262 active site 189918008263 Predicted transcriptional regulator [Transcription]; Region: COG2378 189918008264 HTH domain; Region: HTH_11; pfam08279 189918008265 WYL domain; Region: WYL; pfam13280 189918008266 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918008267 choline dehydrogenase; Validated; Region: PRK02106 189918008268 lycopene cyclase; Region: lycopene_cycl; TIGR01789 189918008269 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189918008270 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 189918008271 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918008272 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 189918008273 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918008274 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 189918008275 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 189918008276 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 189918008277 NIPSNAP; Region: NIPSNAP; pfam07978 189918008278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008280 WHG domain; Region: WHG; pfam13305 189918008281 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918008282 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 189918008283 RibD C-terminal domain; Region: RibD_C; cl17279 189918008284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918008285 Predicted membrane protein [Function unknown]; Region: COG2323 189918008286 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 189918008287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918008288 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189918008289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918008290 DNA binding residues [nucleotide binding] 189918008291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918008292 MarR family; Region: MarR; pfam01047 189918008293 Protein of unknown function (DUF461); Region: DUF461; cl01071 189918008294 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 189918008295 Predicted membrane protein [Function unknown]; Region: COG4325 189918008296 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918008297 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 189918008298 dimerization interface [polypeptide binding]; other site 189918008299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918008302 classical (c) SDRs; Region: SDR_c; cd05233 189918008303 NAD(P) binding site [chemical binding]; other site 189918008304 active site 189918008305 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 189918008306 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 189918008307 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 189918008308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918008309 classical (c) SDRs; Region: SDR_c; cd05233 189918008310 NAD(P) binding site [chemical binding]; other site 189918008311 active site 189918008312 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 189918008313 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 189918008314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 189918008315 AAA domain; Region: AAA_33; pfam13671 189918008316 hypothetical protein; Provisional; Region: PRK06834 189918008317 TrkA-N domain; Region: TrkA_N; pfam02254 189918008318 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918008319 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918008320 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918008321 active site 189918008322 catalytic tetrad [active] 189918008323 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189918008324 RNA binding surface [nucleotide binding]; other site 189918008325 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918008326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918008327 substrate binding site [chemical binding]; other site 189918008328 oxyanion hole (OAH) forming residues; other site 189918008329 trimer interface [polypeptide binding]; other site 189918008330 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 189918008331 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918008332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918008333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918008334 acyl-activating enzyme (AAE) consensus motif; other site 189918008335 acyl-activating enzyme (AAE) consensus motif; other site 189918008336 AMP binding site [chemical binding]; other site 189918008337 active site 189918008338 CoA binding site [chemical binding]; other site 189918008339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 189918008340 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 189918008341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008343 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 189918008344 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918008345 Prostaglandin dehydrogenases; Region: PGDH; cd05288 189918008346 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 189918008347 NAD(P) binding site [chemical binding]; other site 189918008348 substrate binding site [chemical binding]; other site 189918008349 dimer interface [polypeptide binding]; other site 189918008350 MOSC domain; Region: MOSC; pfam03473 189918008351 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918008352 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918008353 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918008354 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918008355 hydrophobic ligand binding site; other site 189918008356 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189918008357 metal binding site 2 [ion binding]; metal-binding site 189918008358 putative DNA binding helix; other site 189918008359 metal binding site 1 [ion binding]; metal-binding site 189918008360 dimer interface [polypeptide binding]; other site 189918008361 structural Zn2+ binding site [ion binding]; other site 189918008362 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 189918008363 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 189918008364 heme binding site [chemical binding]; other site 189918008365 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 189918008366 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189918008367 active site 189918008368 catalytic triad [active] 189918008369 oxyanion hole [active] 189918008370 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918008371 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 189918008372 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 189918008373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918008374 active site 189918008375 phosphorylation site [posttranslational modification] 189918008376 intermolecular recognition site; other site 189918008377 dimerization interface [polypeptide binding]; other site 189918008378 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918008379 CHASE3 domain; Region: CHASE3; pfam05227 189918008380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918008381 dimerization interface [polypeptide binding]; other site 189918008382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918008383 dimer interface [polypeptide binding]; other site 189918008384 phosphorylation site [posttranslational modification] 189918008385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918008386 ATP binding site [chemical binding]; other site 189918008387 Mg2+ binding site [ion binding]; other site 189918008388 G-X-G motif; other site 189918008389 Response regulator receiver domain; Region: Response_reg; pfam00072 189918008390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918008391 active site 189918008392 phosphorylation site [posttranslational modification] 189918008393 intermolecular recognition site; other site 189918008394 dimerization interface [polypeptide binding]; other site 189918008395 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189918008396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918008397 dimerization interface [polypeptide binding]; other site 189918008398 putative DNA binding site [nucleotide binding]; other site 189918008399 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918008400 putative Zn2+ binding site [ion binding]; other site 189918008401 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 189918008402 putative hydrophobic ligand binding site [chemical binding]; other site 189918008403 NlpC/P60 family; Region: NLPC_P60; cl17555 189918008404 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 189918008405 Uncharacterized conserved protein [Function unknown]; Region: COG3379 189918008406 hypothetical protein; Validated; Region: PRK02101 189918008407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918008408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918008409 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918008410 Helix-turn-helix domain; Region: HTH_18; pfam12833 189918008411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918008412 hypothetical protein; Provisional; Region: PRK01346 189918008413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 189918008414 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 189918008415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918008416 catalytic residue [active] 189918008417 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 189918008418 putative active site [active] 189918008419 catalytic residue [active] 189918008420 Amidase; Region: Amidase; cl11426 189918008421 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 189918008422 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918008423 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 189918008424 competence damage-inducible protein A; Provisional; Region: PRK00549 189918008425 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 189918008426 putative MPT binding site; other site 189918008427 Competence-damaged protein; Region: CinA; pfam02464 189918008428 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918008429 Biofilm formation and stress response factor; Region: BsmA; pfam10014 189918008430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008431 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918008432 NAD(P) binding site [chemical binding]; other site 189918008433 active site 189918008434 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918008435 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918008436 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189918008437 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918008438 anti sigma factor interaction site; other site 189918008439 regulatory phosphorylation site [posttranslational modification]; other site 189918008440 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 189918008441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 189918008442 Nitronate monooxygenase; Region: NMO; pfam03060 189918008443 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918008444 FMN binding site [chemical binding]; other site 189918008445 substrate binding site [chemical binding]; other site 189918008446 putative catalytic residue [active] 189918008447 Ferredoxin [Energy production and conversion]; Region: COG1146 189918008448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008450 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 189918008451 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918008452 molybdopterin cofactor binding site; other site 189918008453 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918008454 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 189918008455 putative molybdopterin cofactor binding site; other site 189918008456 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918008457 Cytochrome P450; Region: p450; cl12078 189918008458 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918008459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918008460 non-specific DNA binding site [nucleotide binding]; other site 189918008461 salt bridge; other site 189918008462 sequence-specific DNA binding site [nucleotide binding]; other site 189918008463 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 189918008464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918008465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918008466 DNA-binding site [nucleotide binding]; DNA binding site 189918008467 FCD domain; Region: FCD; cl11656 189918008468 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 189918008469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918008470 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918008471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918008472 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 189918008473 hypothetical protein; Provisional; Region: PRK06815 189918008474 tetramer interface [polypeptide binding]; other site 189918008475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918008476 catalytic residue [active] 189918008477 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189918008478 active site 189918008479 agmatinase; Region: agmatinase; TIGR01230 189918008480 Agmatinase-like family; Region: Agmatinase-like; cd09990 189918008481 active site 189918008482 oligomer interface [polypeptide binding]; other site 189918008483 Mn binding site [ion binding]; other site 189918008484 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918008486 S-adenosylmethionine binding site [chemical binding]; other site 189918008487 chorismate mutase; Provisional; Region: PRK09269 189918008488 Chorismate mutase type II; Region: CM_2; cl00693 189918008489 short chain dehydrogenase; Provisional; Region: PRK08267 189918008490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008491 NAD(P) binding site [chemical binding]; other site 189918008492 active site 189918008493 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918008494 hydrophobic ligand binding site; other site 189918008495 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918008496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918008497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918008498 Cytochrome P450; Region: p450; cl12078 189918008499 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 189918008500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918008501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008502 Predicted RNA-binding proteins [General function prediction only]; Region: PelA; COG1537 189918008503 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 189918008504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918008505 motif II; other site 189918008506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918008507 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 189918008508 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918008509 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918008510 active site 189918008511 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189918008512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918008513 short chain dehydrogenase; Provisional; Region: PRK08303 189918008514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008515 NAD(P) binding site [chemical binding]; other site 189918008516 active site 189918008517 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 189918008518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918008519 active site 189918008520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918008521 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918008522 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 189918008523 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918008524 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918008525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918008526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918008527 putative substrate translocation pore; other site 189918008528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918008529 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 189918008530 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 189918008531 heme binding site [chemical binding]; other site 189918008532 ferroxidase pore; other site 189918008533 ferroxidase diiron center [ion binding]; other site 189918008534 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 189918008535 enoyl-CoA hydratase; Provisional; Region: PRK06688 189918008536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918008537 substrate binding site [chemical binding]; other site 189918008538 oxyanion hole (OAH) forming residues; other site 189918008539 trimer interface [polypeptide binding]; other site 189918008540 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 189918008541 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918008542 CoenzymeA binding site [chemical binding]; other site 189918008543 subunit interaction site [polypeptide binding]; other site 189918008544 PHB binding site; other site 189918008545 Amidase; Region: Amidase; cl11426 189918008546 Isochorismatase family; Region: Isochorismatase; pfam00857 189918008547 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 189918008548 catalytic triad [active] 189918008549 conserved cis-peptide bond; other site 189918008550 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 189918008551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918008552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189918008553 TPR motif; other site 189918008554 TPR repeat; Region: TPR_11; pfam13414 189918008555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189918008556 binding surface 189918008557 TPR motif; other site 189918008558 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 189918008559 nucleoside/Zn binding site; other site 189918008560 dimer interface [polypeptide binding]; other site 189918008561 catalytic motif [active] 189918008562 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 189918008563 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 189918008564 active site 189918008565 catalytic site [active] 189918008566 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 189918008567 Putative esterase; Region: Esterase; pfam00756 189918008568 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 189918008569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918008570 Walker A motif; other site 189918008571 ATP binding site [chemical binding]; other site 189918008572 Walker B motif; other site 189918008573 arginine finger; other site 189918008574 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 189918008575 TfoX N-terminal domain; Region: TfoX_N; cl17592 189918008576 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 189918008577 minor groove reading motif; other site 189918008578 helix-hairpin-helix signature motif; other site 189918008579 Protein of unknown function DUF72; Region: DUF72; pfam01904 189918008580 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 189918008581 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 189918008582 putative ligand binding site [chemical binding]; other site 189918008583 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 189918008584 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 189918008585 putative ligand binding site [chemical binding]; other site 189918008586 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 189918008587 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 189918008588 TM-ABC transporter signature motif; other site 189918008589 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 189918008590 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 189918008591 Walker A/P-loop; other site 189918008592 ATP binding site [chemical binding]; other site 189918008593 Q-loop/lid; other site 189918008594 ABC transporter signature motif; other site 189918008595 Walker B; other site 189918008596 D-loop; other site 189918008597 H-loop/switch region; other site 189918008598 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 189918008599 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189918008600 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918008601 NAD(P) binding site [chemical binding]; other site 189918008602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918008603 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918008604 NAD(P) binding site [chemical binding]; other site 189918008605 active site 189918008606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918008607 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 189918008608 inhibitor binding site; inhibition site 189918008609 catalytic Zn binding site [ion binding]; other site 189918008610 structural Zn binding site [ion binding]; other site 189918008611 NADP binding site [chemical binding]; other site 189918008612 tetramer interface [polypeptide binding]; other site 189918008613 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918008614 phosphate binding site [ion binding]; other site 189918008615 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 189918008616 N- and C-terminal domain interface [polypeptide binding]; other site 189918008617 active site 189918008618 MgATP binding site [chemical binding]; other site 189918008619 catalytic site [active] 189918008620 metal binding site [ion binding]; metal-binding site 189918008621 xylulose binding site [chemical binding]; other site 189918008622 putative homodimer interface [polypeptide binding]; other site 189918008623 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 189918008624 putative active site [active] 189918008625 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 189918008626 Homeodomain-like domain; Region: HTH_23; cl17451 189918008627 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 189918008628 short chain dehydrogenase; Provisional; Region: PRK06841 189918008629 classical (c) SDRs; Region: SDR_c; cd05233 189918008630 NAD(P) binding site [chemical binding]; other site 189918008631 active site 189918008632 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 189918008633 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918008634 active site 189918008635 putative phosphoketolase; Provisional; Region: PRK05261 189918008636 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 189918008637 TPP-binding site; other site 189918008638 XFP C-terminal domain; Region: XFP_C; pfam09363 189918008639 CAAX protease self-immunity; Region: Abi; pfam02517 189918008640 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 189918008641 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 189918008642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008643 Walker A/P-loop; other site 189918008644 ATP binding site [chemical binding]; other site 189918008645 Q-loop/lid; other site 189918008646 ABC transporter signature motif; other site 189918008647 Walker B; other site 189918008648 D-loop; other site 189918008649 H-loop/switch region; other site 189918008650 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189918008651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918008652 putative PBP binding loops; other site 189918008653 ABC-ATPase subunit interface; other site 189918008654 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189918008655 classical (c) SDRs; Region: SDR_c; cd05233 189918008656 NAD(P) binding site [chemical binding]; other site 189918008657 active site 189918008658 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918008659 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918008660 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189918008661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918008662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918008663 UreD urease accessory protein; Region: UreD; cl00530 189918008664 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918008665 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 189918008666 urease subunit alpha; Reviewed; Region: ureC; PRK13206 189918008667 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 189918008668 subunit interactions [polypeptide binding]; other site 189918008669 active site 189918008670 flap region; other site 189918008671 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 189918008672 gamma-beta subunit interface [polypeptide binding]; other site 189918008673 alpha-beta subunit interface [polypeptide binding]; other site 189918008674 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 189918008675 alpha-gamma subunit interface [polypeptide binding]; other site 189918008676 beta-gamma subunit interface [polypeptide binding]; other site 189918008677 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918008678 CoenzymeA binding site [chemical binding]; other site 189918008679 subunit interaction site [polypeptide binding]; other site 189918008680 PHB binding site; other site 189918008681 Predicted transcriptional regulator [Transcription]; Region: COG3682 189918008682 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 189918008683 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918008684 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 189918008685 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 189918008686 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 189918008687 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918008688 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 189918008689 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 189918008690 active site 189918008691 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189918008692 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918008693 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918008694 Transporter associated domain; Region: CorC_HlyC; smart01091 189918008695 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189918008696 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918008697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918008698 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 189918008699 active site 189918008700 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 189918008701 metal ion-dependent adhesion site (MIDAS); other site 189918008702 classical (c) SDRs; Region: SDR_c; cd05233 189918008703 NAD(P) binding site [chemical binding]; other site 189918008704 active site 189918008705 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 189918008706 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 189918008707 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 189918008708 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918008709 hydrophobic ligand binding site; other site 189918008710 DoxX-like family; Region: DoxX_2; pfam13564 189918008711 PE-PPE domain; Region: PE-PPE; pfam08237 189918008712 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918008713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918008714 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918008715 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 189918008716 acyltransferase PapA5; Provisional; Region: PRK09294 189918008717 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189918008718 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918008719 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918008720 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 189918008721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008722 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 189918008723 Walker A/P-loop; other site 189918008724 ATP binding site [chemical binding]; other site 189918008725 Q-loop/lid; other site 189918008726 ABC transporter signature motif; other site 189918008727 Walker B; other site 189918008728 D-loop; other site 189918008729 H-loop/switch region; other site 189918008730 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918008731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918008732 active site 189918008733 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918008734 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918008735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918008736 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 189918008737 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 189918008738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918008739 active site 189918008740 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918008741 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 189918008742 KR domain; Region: KR; pfam08659 189918008743 NADP binding site [chemical binding]; other site 189918008744 active site 189918008745 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918008746 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918008747 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918008748 active site 189918008749 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918008750 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918008751 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918008752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918008753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918008754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918008755 active site 189918008756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918008757 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918008758 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 189918008759 KR domain; Region: KR; pfam08659 189918008760 NADP binding site [chemical binding]; other site 189918008761 active site 189918008762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918008763 acyl-CoA synthetase; Validated; Region: PRK05850 189918008764 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918008765 acyl-activating enzyme (AAE) consensus motif; other site 189918008766 active site 189918008767 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 189918008768 glycine dehydrogenase; Provisional; Region: PRK05367 189918008769 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918008770 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918008771 catalytic residue [active] 189918008772 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 189918008773 tetramer interface [polypeptide binding]; other site 189918008774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918008775 catalytic residue [active] 189918008776 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 189918008777 DNA binding residues [nucleotide binding] 189918008778 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918008779 putative dimer interface [polypeptide binding]; other site 189918008780 Bifunctional nuclease; Region: DNase-RNase; pfam02577 189918008781 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 189918008782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918008783 DNA binding residues [nucleotide binding] 189918008784 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918008785 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918008786 phosphopeptide binding site; other site 189918008787 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 189918008788 lipoyl attachment site [posttranslational modification]; other site 189918008789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 189918008790 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 189918008791 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 189918008792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 189918008793 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 189918008794 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 189918008795 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 189918008796 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 189918008797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918008798 nucleotide binding region [chemical binding]; other site 189918008799 ATP-binding site [chemical binding]; other site 189918008800 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189918008801 hypothetical protein; Provisional; Region: PRK06184 189918008802 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918008803 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 189918008804 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 189918008805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008806 Walker A/P-loop; other site 189918008807 ATP binding site [chemical binding]; other site 189918008808 Q-loop/lid; other site 189918008809 ABC transporter signature motif; other site 189918008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918008811 ABC transporter signature motif; other site 189918008812 Walker B; other site 189918008813 D-loop; other site 189918008814 H-loop/switch region; other site 189918008815 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 189918008816 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 189918008817 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 189918008818 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918008819 hypothetical protein; Validated; Region: PRK07121 189918008820 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918008821 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 189918008822 metal binding site [ion binding]; metal-binding site 189918008823 substrate binding site [chemical binding]; other site 189918008824 dimer interface [polypeptide binding]; other site 189918008825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918008826 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918008827 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 189918008828 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918008829 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 189918008830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 189918008831 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 189918008832 TrkA-C domain; Region: TrkA_C; pfam02080 189918008833 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189918008834 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189918008835 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 189918008836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918008837 substrate binding pocket [chemical binding]; other site 189918008838 catalytic triad [active] 189918008839 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 189918008840 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 189918008841 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 189918008842 classical (c) SDRs; Region: SDR_c; cd05233 189918008843 NAD(P) binding site [chemical binding]; other site 189918008844 active site 189918008845 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918008846 hydrophobic ligand binding site; other site 189918008847 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918008848 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918008849 putative acyl-acceptor binding pocket; other site 189918008850 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 189918008851 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 189918008852 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 189918008853 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 189918008854 FMN-binding pocket [chemical binding]; other site 189918008855 flavin binding motif; other site 189918008856 phosphate binding motif [ion binding]; other site 189918008857 beta-alpha-beta structure motif; other site 189918008858 NAD binding pocket [chemical binding]; other site 189918008859 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918008860 catalytic loop [active] 189918008861 iron binding site [ion binding]; other site 189918008862 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918008863 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918008864 SnoaL-like domain; Region: SnoaL_4; pfam13577 189918008865 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189918008866 nudix motif; other site 189918008867 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189918008868 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 189918008869 intracellular protease, PfpI family; Region: PfpI; TIGR01382 189918008870 proposed catalytic triad [active] 189918008871 conserved cys residue [active] 189918008872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918008873 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918008874 substrate binding pocket [chemical binding]; other site 189918008875 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 189918008876 active site 189918008877 catalytic triad [active] 189918008878 oxyanion hole [active] 189918008879 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918008880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918008881 S-adenosylmethionine binding site [chemical binding]; other site 189918008882 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 189918008883 acyl-CoA synthetase; Validated; Region: PRK07798 189918008884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918008885 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 189918008886 acyl-activating enzyme (AAE) consensus motif; other site 189918008887 acyl-activating enzyme (AAE) consensus motif; other site 189918008888 putative AMP binding site [chemical binding]; other site 189918008889 putative active site [active] 189918008890 putative CoA binding site [chemical binding]; other site 189918008891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918008892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189918008893 PAS domain; Region: PAS_9; pfam13426 189918008894 putative active site [active] 189918008895 heme pocket [chemical binding]; other site 189918008896 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918008897 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918008898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918008899 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918008900 acyl-activating enzyme (AAE) consensus motif; other site 189918008901 acyl-activating enzyme (AAE) consensus motif; other site 189918008902 putative AMP binding site [chemical binding]; other site 189918008903 putative active site [active] 189918008904 putative CoA binding site [chemical binding]; other site 189918008905 SOUL heme-binding protein; Region: SOUL; pfam04832 189918008906 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 189918008907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918008908 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189918008909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918008910 DNA binding residues [nucleotide binding] 189918008911 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918008912 anti sigma factor interaction site; other site 189918008913 regulatory phosphorylation site [posttranslational modification]; other site 189918008914 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 189918008915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189918008916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918008917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918008918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918008919 active site 189918008920 phosphorylation site [posttranslational modification] 189918008921 intermolecular recognition site; other site 189918008922 dimerization interface [polypeptide binding]; other site 189918008923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918008924 DNA binding site [nucleotide binding] 189918008925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918008926 dimerization interface [polypeptide binding]; other site 189918008927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918008928 dimer interface [polypeptide binding]; other site 189918008929 phosphorylation site [posttranslational modification] 189918008930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918008931 ATP binding site [chemical binding]; other site 189918008932 Mg2+ binding site [ion binding]; other site 189918008933 G-X-G motif; other site 189918008934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918008935 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918008936 active site 189918008937 ATP binding site [chemical binding]; other site 189918008938 substrate binding site [chemical binding]; other site 189918008939 activation loop (A-loop); other site 189918008940 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918008941 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918008942 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 189918008943 Phage capsid family; Region: Phage_capsid; pfam05065 189918008944 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 189918008945 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 189918008946 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 189918008947 HNH endonuclease; Region: HNH_3; pfam13392 189918008948 AAA domain; Region: AAA_25; pfam13481 189918008949 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189918008950 Walker A motif; other site 189918008951 ATP binding site [chemical binding]; other site 189918008952 Walker B motif; other site 189918008953 Helix-turn-helix domain; Region: HTH_17; pfam12728 189918008954 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 189918008955 Int/Topo IB signature motif; other site 189918008956 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 189918008957 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 189918008958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918008959 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918008960 GTP-binding protein Der; Reviewed; Region: PRK03003 189918008961 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 189918008962 G1 box; other site 189918008963 GTP/Mg2+ binding site [chemical binding]; other site 189918008964 Switch I region; other site 189918008965 G2 box; other site 189918008966 Switch II region; other site 189918008967 G3 box; other site 189918008968 G4 box; other site 189918008969 G5 box; other site 189918008970 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 189918008971 G1 box; other site 189918008972 GTP/Mg2+ binding site [chemical binding]; other site 189918008973 Switch I region; other site 189918008974 G2 box; other site 189918008975 G3 box; other site 189918008976 Switch II region; other site 189918008977 G4 box; other site 189918008978 G5 box; other site 189918008979 cytidylate kinase; Provisional; Region: cmk; PRK00023 189918008980 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 189918008981 active site 189918008982 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 189918008983 CMP-binding site; other site 189918008984 The sites determining sugar specificity; other site 189918008985 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 189918008986 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189918008987 RNA binding surface [nucleotide binding]; other site 189918008988 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 189918008989 active site 189918008990 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 189918008991 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 189918008992 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189918008993 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918008994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189918008995 Magnesium ion binding site [ion binding]; other site 189918008996 MMPL family; Region: MMPL; pfam03176 189918008997 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918008998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918008999 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 189918009000 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918009001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009002 homodimer interface [polypeptide binding]; other site 189918009003 catalytic residue [active] 189918009004 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 189918009005 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 189918009006 active site 189918009007 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 189918009008 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 189918009009 PYR/PP interface [polypeptide binding]; other site 189918009010 dimer interface [polypeptide binding]; other site 189918009011 TPP binding site [chemical binding]; other site 189918009012 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 189918009013 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 189918009014 TPP-binding site [chemical binding]; other site 189918009015 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918009016 Cytochrome P450; Region: p450; cl12078 189918009017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189918009018 putative DNA binding site [nucleotide binding]; other site 189918009019 putative Zn2+ binding site [ion binding]; other site 189918009020 O-methyltransferase; Region: Methyltransf_2; pfam00891 189918009021 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 189918009022 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918009023 active site 189918009024 DNA binding site [nucleotide binding] 189918009025 Int/Topo IB signature motif; other site 189918009026 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 189918009027 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 189918009028 dimer interface [polypeptide binding]; other site 189918009029 ADP-ribose binding site [chemical binding]; other site 189918009030 active site 189918009031 nudix motif; other site 189918009032 metal binding site [ion binding]; metal-binding site 189918009033 CTP synthetase; Validated; Region: pyrG; PRK05380 189918009034 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 189918009035 active site 189918009036 UTP binding site [chemical binding]; other site 189918009037 Catalytic site [active] 189918009038 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 189918009039 active site 189918009040 putative oxyanion hole; other site 189918009041 catalytic triad [active] 189918009042 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 189918009043 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 189918009044 Thiamine pyrophosphokinase; Region: TPK; cl08415 189918009045 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 189918009046 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 189918009047 active site 189918009048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009050 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 189918009051 DNA repair protein RecN; Region: recN; TIGR00634 189918009052 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 189918009053 Walker A/P-loop; other site 189918009054 ATP binding site [chemical binding]; other site 189918009055 Q-loop/lid; other site 189918009056 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 189918009057 ABC transporter signature motif; other site 189918009058 Walker B; other site 189918009059 D-loop; other site 189918009060 H-loop/switch region; other site 189918009061 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 189918009062 ATP-NAD kinase; Region: NAD_kinase; pfam01513 189918009063 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 189918009064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189918009065 RNA binding surface [nucleotide binding]; other site 189918009066 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 189918009067 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 189918009068 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 189918009069 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 189918009070 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 189918009071 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 189918009072 active site 189918009073 HIGH motif; other site 189918009074 dimer interface [polypeptide binding]; other site 189918009075 KMSKS motif; other site 189918009076 S4 RNA-binding domain; Region: S4; smart00363 189918009077 RNA binding surface [nucleotide binding]; other site 189918009078 3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802 189918009079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 189918009080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918009081 Walker A/P-loop; other site 189918009082 ATP binding site [chemical binding]; other site 189918009083 Q-loop/lid; other site 189918009084 ABC transporter signature motif; other site 189918009085 Walker B; other site 189918009086 D-loop; other site 189918009087 H-loop/switch region; other site 189918009088 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189918009089 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918009090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009092 Uncharacterized conserved protein [Function unknown]; Region: COG2835 189918009093 acyl-CoA synthetase; Validated; Region: PRK07868 189918009094 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 189918009095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918009096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918009097 active site 189918009098 CoA binding site [chemical binding]; other site 189918009099 AMP binding site [chemical binding]; other site 189918009100 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189918009101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918009102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918009103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918009104 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918009105 argininosuccinate lyase; Provisional; Region: PRK00855 189918009106 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 189918009107 active sites [active] 189918009108 tetramer interface [polypeptide binding]; other site 189918009109 argininosuccinate synthase; Provisional; Region: PRK13820 189918009110 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 189918009111 ANP binding site [chemical binding]; other site 189918009112 Substrate Binding Site II [chemical binding]; other site 189918009113 Substrate Binding Site I [chemical binding]; other site 189918009114 arginine repressor; Provisional; Region: PRK03341 189918009115 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 189918009116 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 189918009117 ornithine carbamoyltransferase; Provisional; Region: PRK00779 189918009118 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 189918009119 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 189918009120 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 189918009121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918009122 inhibitor-cofactor binding pocket; inhibition site 189918009123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009124 catalytic residue [active] 189918009125 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 189918009126 feedback inhibition sensing region; other site 189918009127 homohexameric interface [polypeptide binding]; other site 189918009128 nucleotide binding site [chemical binding]; other site 189918009129 N-acetyl-L-glutamate binding site [chemical binding]; other site 189918009130 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 189918009131 heterotetramer interface [polypeptide binding]; other site 189918009132 active site pocket [active] 189918009133 cleavage site 189918009134 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 189918009135 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 189918009136 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 189918009137 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 189918009138 putative tRNA-binding site [nucleotide binding]; other site 189918009139 B3/4 domain; Region: B3_4; pfam03483 189918009140 tRNA synthetase B5 domain; Region: B5; smart00874 189918009141 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 189918009142 dimer interface [polypeptide binding]; other site 189918009143 motif 1; other site 189918009144 motif 3; other site 189918009145 motif 2; other site 189918009146 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 189918009147 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 189918009148 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 189918009149 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 189918009150 dimer interface [polypeptide binding]; other site 189918009151 motif 1; other site 189918009152 active site 189918009153 motif 2; other site 189918009154 motif 3; other site 189918009155 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918009156 cyclase homology domain; Region: CHD; cd07302 189918009157 nucleotidyl binding site; other site 189918009158 metal binding site [ion binding]; metal-binding site 189918009159 dimer interface [polypeptide binding]; other site 189918009160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 189918009161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918009162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918009163 active site 189918009164 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189918009165 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 189918009166 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189918009167 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 189918009168 23S rRNA binding site [nucleotide binding]; other site 189918009169 L21 binding site [polypeptide binding]; other site 189918009170 L13 binding site [polypeptide binding]; other site 189918009171 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 189918009172 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 189918009173 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 189918009174 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 189918009175 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 189918009176 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 189918009177 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 189918009178 dimer interface [polypeptide binding]; other site 189918009179 putative anticodon binding site; other site 189918009180 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189918009181 motif 1; other site 189918009182 dimer interface [polypeptide binding]; other site 189918009183 active site 189918009184 motif 2; other site 189918009185 motif 3; other site 189918009186 Predicted esterase [General function prediction only]; Region: COG0627 189918009187 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 189918009188 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 189918009189 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918009190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918009191 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 189918009192 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189918009193 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189918009194 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 189918009195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918009196 Domain of unknown function (DUF427); Region: DUF427; pfam04248 189918009197 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918009198 Cytochrome P450; Region: p450; cl12078 189918009199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918009200 Ligand Binding Site [chemical binding]; other site 189918009201 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 189918009202 Fe-S cluster binding site [ion binding]; other site 189918009203 active site 189918009204 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 189918009205 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918009206 active site 189918009207 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918009208 catalytic triad [active] 189918009209 dimer interface [polypeptide binding]; other site 189918009210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918009211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918009212 dimer interface [polypeptide binding]; other site 189918009213 phosphorylation site [posttranslational modification] 189918009214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918009215 ATP binding site [chemical binding]; other site 189918009216 Mg2+ binding site [ion binding]; other site 189918009217 G-X-G motif; other site 189918009218 Predicted membrane protein [Function unknown]; Region: COG5373 189918009219 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 189918009220 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 189918009221 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918009222 putative metal binding site [ion binding]; other site 189918009223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918009224 dimerization interface [polypeptide binding]; other site 189918009225 putative DNA binding site [nucleotide binding]; other site 189918009226 putative Zn2+ binding site [ion binding]; other site 189918009227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918009228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918009229 putative substrate translocation pore; other site 189918009230 excinuclease ABC subunit B; Provisional; Region: PRK05298 189918009231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918009232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918009233 nucleotide binding region [chemical binding]; other site 189918009234 ATP-binding site [chemical binding]; other site 189918009235 Ultra-violet resistance protein B; Region: UvrB; pfam12344 189918009236 UvrB/uvrC motif; Region: UVR; pfam02151 189918009237 Protein of unknown function (DUF402); Region: DUF402; cl00979 189918009238 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 189918009239 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 189918009240 CoA-binding site [chemical binding]; other site 189918009241 ATP-binding [chemical binding]; other site 189918009242 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 189918009243 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 189918009244 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 189918009245 RNA binding site [nucleotide binding]; other site 189918009246 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 189918009247 RNA binding site [nucleotide binding]; other site 189918009248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189918009249 RNA binding site [nucleotide binding]; other site 189918009250 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 189918009251 RNA binding site [nucleotide binding]; other site 189918009252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918009255 NADH(P)-binding; Region: NAD_binding_10; pfam13460 189918009256 NAD(P) binding site [chemical binding]; other site 189918009257 active site 189918009258 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 189918009259 Protease prsW family; Region: PrsW-protease; pfam13367 189918009260 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 189918009261 5'-3' exonuclease; Region: 53EXOc; smart00475 189918009262 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 189918009263 active site 189918009264 metal binding site 1 [ion binding]; metal-binding site 189918009265 putative 5' ssDNA interaction site; other site 189918009266 metal binding site 3; metal-binding site 189918009267 metal binding site 2 [ion binding]; metal-binding site 189918009268 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 189918009269 putative DNA binding site [nucleotide binding]; other site 189918009270 putative metal binding site [ion binding]; other site 189918009271 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 189918009272 active site 189918009273 substrate binding site [chemical binding]; other site 189918009274 DNA polymerase I; Provisional; Region: PRK05755 189918009275 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 189918009276 active site 189918009277 DNA binding site [nucleotide binding] 189918009278 catalytic site [active] 189918009279 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 189918009280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918009281 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 189918009282 putative dimerization interface [polypeptide binding]; other site 189918009283 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 189918009284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918009285 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 189918009286 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918009287 lipid-transfer protein; Provisional; Region: PRK06059 189918009288 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918009289 active site 189918009290 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 189918009291 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 189918009292 Walker A/P-loop; other site 189918009293 ATP binding site [chemical binding]; other site 189918009294 Q-loop/lid; other site 189918009295 ABC transporter signature motif; other site 189918009296 Walker B; other site 189918009297 D-loop; other site 189918009298 H-loop/switch region; other site 189918009299 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 189918009300 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 189918009301 Walker A/P-loop; other site 189918009302 ATP binding site [chemical binding]; other site 189918009303 Q-loop/lid; other site 189918009304 ABC transporter signature motif; other site 189918009305 Walker B; other site 189918009306 D-loop; other site 189918009307 H-loop/switch region; other site 189918009308 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 189918009309 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 189918009310 TM-ABC transporter signature motif; other site 189918009311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 189918009312 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 189918009313 TM-ABC transporter signature motif; other site 189918009314 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 189918009315 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 189918009316 dimerization interface [polypeptide binding]; other site 189918009317 ligand binding site [chemical binding]; other site 189918009318 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 189918009319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918009320 active site 189918009321 phosphorylation site [posttranslational modification] 189918009322 intermolecular recognition site; other site 189918009323 dimerization interface [polypeptide binding]; other site 189918009324 ANTAR domain; Region: ANTAR; pfam03861 189918009325 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 189918009326 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918009327 active site 189918009328 DNA binding site [nucleotide binding] 189918009329 Int/Topo IB signature motif; other site 189918009330 AAA domain; Region: AAA_25; pfam13481 189918009331 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189918009332 Walker A motif; other site 189918009333 ATP binding site [chemical binding]; other site 189918009334 Walker B motif; other site 189918009335 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 189918009336 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 189918009337 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 189918009338 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 189918009339 Phage capsid family; Region: Phage_capsid; pfam05065 189918009340 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 189918009341 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 189918009342 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 189918009343 agmatinase; Region: agmatinase; TIGR01230 189918009344 oligomer interface [polypeptide binding]; other site 189918009345 putative active site [active] 189918009346 Mn binding site [ion binding]; other site 189918009347 Heme NO binding associated; Region: HNOBA; pfam07701 189918009348 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189918009349 cyclase homology domain; Region: CHD; cd07302 189918009350 nucleotidyl binding site; other site 189918009351 metal binding site [ion binding]; metal-binding site 189918009352 dimer interface [polypeptide binding]; other site 189918009353 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 189918009354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918009355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918009356 hydrophobic ligand binding site; other site 189918009357 Ferritin-like domain; Region: Ferritin; pfam00210 189918009358 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 189918009359 dimerization interface [polypeptide binding]; other site 189918009360 DPS ferroxidase diiron center [ion binding]; other site 189918009361 ion pore; other site 189918009362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918009363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918009364 active site 189918009365 phosphorylation site [posttranslational modification] 189918009366 intermolecular recognition site; other site 189918009367 dimerization interface [polypeptide binding]; other site 189918009368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918009369 DNA binding residues [nucleotide binding] 189918009370 dimerization interface [polypeptide binding]; other site 189918009371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918009372 ATP binding site [chemical binding]; other site 189918009373 G-X-G motif; other site 189918009374 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918009375 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 189918009376 Walker A/P-loop; other site 189918009377 ATP binding site [chemical binding]; other site 189918009378 Q-loop/lid; other site 189918009379 ABC transporter signature motif; other site 189918009380 Walker B; other site 189918009381 D-loop; other site 189918009382 H-loop/switch region; other site 189918009383 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 189918009384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918009385 dimer interface [polypeptide binding]; other site 189918009386 conserved gate region; other site 189918009387 putative PBP binding loops; other site 189918009388 ABC-ATPase subunit interface; other site 189918009389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918009390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918009391 substrate binding pocket [chemical binding]; other site 189918009392 membrane-bound complex binding site; other site 189918009393 hinge residues; other site 189918009394 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 189918009395 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 189918009396 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 189918009397 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 189918009398 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 189918009399 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 189918009400 Walker A/P-loop; other site 189918009401 ATP binding site [chemical binding]; other site 189918009402 Q-loop/lid; other site 189918009403 ABC transporter signature motif; other site 189918009404 Walker B; other site 189918009405 D-loop; other site 189918009406 H-loop/switch region; other site 189918009407 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 189918009408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918009409 Walker A/P-loop; other site 189918009410 ATP binding site [chemical binding]; other site 189918009411 Q-loop/lid; other site 189918009412 ABC transporter signature motif; other site 189918009413 Walker B; other site 189918009414 D-loop; other site 189918009415 H-loop/switch region; other site 189918009416 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 189918009417 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918009418 active site 189918009419 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918009420 catalytic triad [active] 189918009421 dimer interface [polypeptide binding]; other site 189918009422 pyruvate kinase; Provisional; Region: PRK06247 189918009423 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 189918009424 domain interfaces; other site 189918009425 active site 189918009426 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 189918009427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918009428 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 189918009429 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 189918009430 active site 189918009431 dimer interface [polypeptide binding]; other site 189918009432 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 189918009433 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189918009434 active site 189918009435 FMN binding site [chemical binding]; other site 189918009436 substrate binding site [chemical binding]; other site 189918009437 3Fe-4S cluster binding site [ion binding]; other site 189918009438 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 189918009439 domain interface; other site 189918009440 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 189918009441 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918009442 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918009443 active site 189918009444 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 189918009445 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 189918009446 substrate binding site [chemical binding]; other site 189918009447 active site 189918009448 catalytic residues [active] 189918009449 heterodimer interface [polypeptide binding]; other site 189918009450 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 189918009451 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 189918009452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009453 catalytic residue [active] 189918009454 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 189918009455 active site 189918009456 ribulose/triose binding site [chemical binding]; other site 189918009457 phosphate binding site [ion binding]; other site 189918009458 substrate (anthranilate) binding pocket [chemical binding]; other site 189918009459 product (indole) binding pocket [chemical binding]; other site 189918009460 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 189918009461 anthranilate synthase component I; Provisional; Region: PRK13571 189918009462 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 189918009463 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 189918009464 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 189918009465 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 189918009466 catalytic triad [active] 189918009467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918009468 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918009469 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 189918009470 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 189918009471 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 189918009472 substrate binding site [chemical binding]; other site 189918009473 glutamase interaction surface [polypeptide binding]; other site 189918009474 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 189918009475 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 189918009476 active site 189918009477 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 189918009478 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 189918009479 catalytic residues [active] 189918009480 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 189918009481 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 189918009482 putative active site [active] 189918009483 oxyanion strand; other site 189918009484 catalytic triad [active] 189918009485 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 189918009486 putative active site pocket [active] 189918009487 4-fold oligomerization interface [polypeptide binding]; other site 189918009488 metal binding residues [ion binding]; metal-binding site 189918009489 3-fold/trimer interface [polypeptide binding]; other site 189918009490 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 189918009491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918009492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009493 homodimer interface [polypeptide binding]; other site 189918009494 catalytic residue [active] 189918009495 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 189918009496 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 189918009497 NAD binding site [chemical binding]; other site 189918009498 dimerization interface [polypeptide binding]; other site 189918009499 product binding site; other site 189918009500 substrate binding site [chemical binding]; other site 189918009501 zinc binding site [ion binding]; other site 189918009502 catalytic residues [active] 189918009503 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918009504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918009505 non-specific DNA binding site [nucleotide binding]; other site 189918009506 salt bridge; other site 189918009507 sequence-specific DNA binding site [nucleotide binding]; other site 189918009508 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 189918009509 active site 189918009510 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 189918009511 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 189918009512 dimerization interface [polypeptide binding]; other site 189918009513 active site 189918009514 L-aspartate oxidase; Provisional; Region: PRK07804 189918009515 L-aspartate oxidase; Provisional; Region: PRK06175 189918009516 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189918009517 quinolinate synthetase; Provisional; Region: PRK09375 189918009518 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 189918009519 nudix motif; other site 189918009520 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 189918009521 Secretory lipase; Region: LIP; pfam03583 189918009522 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 189918009523 biotin synthase; Validated; Region: PRK06256 189918009524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918009525 FeS/SAM binding site; other site 189918009526 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 189918009527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009528 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 189918009529 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 189918009530 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 189918009531 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 189918009532 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 189918009533 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918009534 catalytic residue [active] 189918009535 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 189918009536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918009537 inhibitor-cofactor binding pocket; inhibition site 189918009538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009539 catalytic residue [active] 189918009540 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918009541 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 189918009542 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 189918009543 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 189918009544 active site 189918009545 catalytic site [active] 189918009546 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 189918009547 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 189918009548 active site 189918009549 catalytic site [active] 189918009550 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 189918009551 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 189918009552 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 189918009553 catalytic site [active] 189918009554 active site 189918009555 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 189918009556 threonine dehydratase; Validated; Region: PRK08639 189918009557 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 189918009558 tetramer interface [polypeptide binding]; other site 189918009559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918009560 catalytic residue [active] 189918009561 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 189918009562 putative Ile/Val binding site [chemical binding]; other site 189918009563 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918009564 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 189918009565 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 189918009566 active site 189918009567 PHP Thumb interface [polypeptide binding]; other site 189918009568 metal binding site [ion binding]; metal-binding site 189918009569 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 189918009570 generic binding surface II; other site 189918009571 generic binding surface I; other site 189918009572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009574 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 189918009575 YCII-related domain; Region: YCII; cl00999 189918009576 Predicted permeases [General function prediction only]; Region: RarD; COG2962 189918009577 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 189918009578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 189918009579 RNA binding surface [nucleotide binding]; other site 189918009580 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 189918009581 active site 189918009582 lipoprotein signal peptidase; Provisional; Region: PRK14764 189918009583 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 189918009584 active site 189918009585 homotetramer interface [polypeptide binding]; other site 189918009586 homodimer interface [polypeptide binding]; other site 189918009587 DNA polymerase IV; Provisional; Region: PRK03348 189918009588 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 189918009589 active site 189918009590 DNA binding site [nucleotide binding] 189918009591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189918009592 RNA binding surface [nucleotide binding]; other site 189918009593 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918009594 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 189918009595 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918009596 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 189918009597 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 189918009598 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 189918009599 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 189918009600 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918009601 active site 189918009602 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 189918009603 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 189918009604 HIGH motif; other site 189918009605 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 189918009606 active site 189918009607 KMSKS motif; other site 189918009608 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 189918009609 tRNA binding surface [nucleotide binding]; other site 189918009610 anticodon binding site; other site 189918009611 peptide synthase; Provisional; Region: PRK12467 189918009612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 189918009613 acyl-CoA synthetase; Validated; Region: PRK05850 189918009614 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918009615 acyl-activating enzyme (AAE) consensus motif; other site 189918009616 active site 189918009617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918009618 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 189918009619 Walker A/P-loop; other site 189918009620 ATP binding site [chemical binding]; other site 189918009621 Q-loop/lid; other site 189918009622 ABC transporter signature motif; other site 189918009623 Walker B; other site 189918009624 D-loop; other site 189918009625 H-loop/switch region; other site 189918009626 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918009627 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189918009628 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 189918009629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 189918009630 active site 189918009631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918009632 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189918009633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918009634 active site 189918009635 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 189918009636 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 189918009637 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189918009638 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 189918009639 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 189918009640 Transport protein; Region: actII; TIGR00833 189918009641 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 189918009642 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 189918009643 homodimer interface [polypeptide binding]; other site 189918009644 active site 189918009645 TDP-binding site; other site 189918009646 acceptor substrate-binding pocket; other site 189918009647 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918009648 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918009649 Condensation domain; Region: Condensation; pfam00668 189918009650 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 189918009651 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918009652 active site 189918009653 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918009654 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 189918009655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918009656 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 189918009657 Enoylreductase; Region: PKS_ER; smart00829 189918009658 NAD(P) binding site [chemical binding]; other site 189918009659 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 189918009660 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 189918009661 putative NADP binding site [chemical binding]; other site 189918009662 active site 189918009663 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918009664 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918009665 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918009666 membrane ATPase/protein kinase; Provisional; Region: PRK09435 189918009667 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 189918009668 Walker A; other site 189918009669 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 189918009670 G4 box; other site 189918009671 G5 box; other site 189918009672 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 189918009673 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 189918009674 active site 189918009675 substrate binding site [chemical binding]; other site 189918009676 coenzyme B12 binding site [chemical binding]; other site 189918009677 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 189918009678 B12 binding site [chemical binding]; other site 189918009679 cobalt ligand [ion binding]; other site 189918009680 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 189918009681 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 189918009682 heterodimer interface [polypeptide binding]; other site 189918009683 substrate interaction site [chemical binding]; other site 189918009684 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 189918009685 Uncharacterized conserved protein [Function unknown]; Region: COG0398 189918009686 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 189918009687 DoxX-like family; Region: DoxX_2; pfam13564 189918009688 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 189918009689 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 189918009690 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 189918009691 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 189918009692 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 189918009693 active site 189918009694 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 189918009695 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 189918009696 active site 189918009697 Pup-like protein; Region: Pup; cl05289 189918009698 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 189918009699 proteasome ATPase; Region: pup_AAA; TIGR03689 189918009700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918009701 Walker A motif; other site 189918009702 ATP binding site [chemical binding]; other site 189918009703 Walker B motif; other site 189918009704 arginine finger; other site 189918009705 Protein of unknown function (DUF503); Region: DUF503; pfam04456 189918009706 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 189918009707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918009708 S-adenosylmethionine binding site [chemical binding]; other site 189918009709 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 189918009710 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189918009711 DinB superfamily; Region: DinB_2; pfam12867 189918009712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009713 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 189918009714 putative dimer interface [polypeptide binding]; other site 189918009715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918009716 mercuric reductase; Validated; Region: PRK06370 189918009717 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918009718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918009719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 189918009720 Predicted membrane protein [Function unknown]; Region: COG3918 189918009721 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 189918009722 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 189918009723 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 189918009724 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 189918009725 homodimer interface [polypeptide binding]; other site 189918009726 putative metal binding site [ion binding]; other site 189918009727 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 189918009728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918009729 putative substrate translocation pore; other site 189918009730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918009731 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 189918009732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918009733 motif II; other site 189918009734 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 189918009735 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 189918009736 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 189918009737 substrate binding pocket [chemical binding]; other site 189918009738 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 189918009739 B12 binding site [chemical binding]; other site 189918009740 cobalt ligand [ion binding]; other site 189918009741 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 189918009742 PAC2 family; Region: PAC2; pfam09754 189918009743 Uncharacterized conserved protein [Function unknown]; Region: COG5361 189918009744 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 189918009745 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 189918009746 short chain dehydrogenase; Provisional; Region: PRK05872 189918009747 classical (c) SDRs; Region: SDR_c; cd05233 189918009748 NAD(P) binding site [chemical binding]; other site 189918009749 active site 189918009750 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 189918009751 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 189918009752 active site 189918009753 HIGH motif; other site 189918009754 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 189918009755 active site 189918009756 KMSKS motif; other site 189918009757 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 189918009758 putative tRNA binding surface [nucleotide binding]; other site 189918009759 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 189918009760 active site 189918009761 conserved hypothetical protein; Region: TIGR03843 189918009762 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 189918009763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918009764 catalytic core [active] 189918009765 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 189918009766 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 189918009767 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 189918009768 quinone interaction residues [chemical binding]; other site 189918009769 active site 189918009770 catalytic residues [active] 189918009771 FMN binding site [chemical binding]; other site 189918009772 substrate binding site [chemical binding]; other site 189918009773 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 189918009774 substrate binding site [chemical binding]; other site 189918009775 hypothetical protein; Provisional; Region: PRK07906 189918009776 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 189918009777 putative metal binding site [ion binding]; other site 189918009778 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 189918009779 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 189918009780 catalytic residues [active] 189918009781 catalytic nucleophile [active] 189918009782 Recombinase; Region: Recombinase; pfam07508 189918009783 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 189918009784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918009785 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918009786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918009787 non-specific DNA binding site [nucleotide binding]; other site 189918009788 salt bridge; other site 189918009789 sequence-specific DNA binding site [nucleotide binding]; other site 189918009790 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 189918009791 nudix motif; other site 189918009792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918009793 Zn2+ binding site [ion binding]; other site 189918009794 Mg2+ binding site [ion binding]; other site 189918009795 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 189918009796 ThiF family; Region: ThiF; pfam00899 189918009797 ATP binding site [chemical binding]; other site 189918009798 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 189918009799 active site 189918009800 NTP binding site [chemical binding]; other site 189918009801 metal binding triad [ion binding]; metal-binding site 189918009802 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 189918009803 active site 189918009804 nucleophile elbow; other site 189918009805 putative transposase OrfB; Reviewed; Region: PHA02517 189918009806 Integrase core domain; Region: rve; pfam00665 189918009807 Integrase core domain; Region: rve_2; pfam13333 189918009808 Integrase core domain; Region: rve; pfam00665 189918009809 Integrase core domain; Region: rve_3; cl15866 189918009810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918009811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918009812 active site 189918009813 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 189918009814 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918009815 NAD binding site [chemical binding]; other site 189918009816 catalytic Zn binding site [ion binding]; other site 189918009817 substrate binding site [chemical binding]; other site 189918009818 structural Zn binding site [ion binding]; other site 189918009819 SCP-2 sterol transfer family; Region: SCP2; pfam02036 189918009820 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 189918009821 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 189918009822 putative active site [active] 189918009823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918009824 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918009825 active site 189918009826 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918009827 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 189918009828 dimer interface [polypeptide binding]; other site 189918009829 acyl-activating enzyme (AAE) consensus motif; other site 189918009830 putative active site [active] 189918009831 AMP binding site [chemical binding]; other site 189918009832 putative CoA binding site [chemical binding]; other site 189918009833 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 189918009834 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 189918009835 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 189918009836 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 189918009837 Cytochrome P450; Region: p450; cl12078 189918009838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918009839 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918009840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189918009841 Transposase; Region: HTH_Tnp_1; pfam01527 189918009842 HTH-like domain; Region: HTH_21; pfam13276 189918009843 Integrase core domain; Region: rve; pfam00665 189918009844 Integrase core domain; Region: rve_3; pfam13683 189918009845 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918009846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918009847 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 189918009848 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918009849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918009850 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918009851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918009852 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918009853 classical (c) SDRs; Region: SDR_c; cd05233 189918009854 NAD(P) binding site [chemical binding]; other site 189918009855 active site 189918009856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009858 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 189918009859 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 189918009860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009861 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 189918009862 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918009863 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 189918009864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918009865 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918009866 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 189918009867 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918009868 carboxyltransferase (CT) interaction site; other site 189918009869 biotinylation site [posttranslational modification]; other site 189918009870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918009871 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918009872 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918009873 active site 189918009874 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918009875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918009876 acyl-activating enzyme (AAE) consensus motif; other site 189918009877 AMP binding site [chemical binding]; other site 189918009878 active site 189918009879 CoA binding site [chemical binding]; other site 189918009880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009882 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 189918009883 TIGR03084 family protein; Region: TIGR03084 189918009884 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918009885 Wyosine base formation; Region: Wyosine_form; pfam08608 189918009886 enoyl-CoA hydratase; Provisional; Region: PRK06494 189918009887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918009888 substrate binding site [chemical binding]; other site 189918009889 oxyanion hole (OAH) forming residues; other site 189918009890 trimer interface [polypeptide binding]; other site 189918009891 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918009892 active site 2 [active] 189918009893 active site 1 [active] 189918009894 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 189918009895 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189918009896 active site 2 [active] 189918009897 active site 1 [active] 189918009898 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918009899 active site 189918009900 catalytic site [active] 189918009901 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918009902 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 189918009903 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 189918009904 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918009905 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918009906 thiolase; Provisional; Region: PRK06158 189918009907 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918009908 active site 189918009909 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 189918009910 Helix-turn-helix domain; Region: HTH_18; pfam12833 189918009911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918009912 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 189918009913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918009914 catalytic loop [active] 189918009915 iron binding site [ion binding]; other site 189918009916 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918009917 Cytochrome P450; Region: p450; cl12078 189918009918 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 189918009919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918009920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918009921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009923 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918009924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918009925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918009926 CoenzymeA binding site [chemical binding]; other site 189918009927 subunit interaction site [polypeptide binding]; other site 189918009928 PHB binding site; other site 189918009929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918009930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918009931 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 189918009932 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 189918009933 active site 189918009934 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918009935 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 189918009936 NAD(P) binding site [chemical binding]; other site 189918009937 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918009938 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918009939 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 189918009940 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 189918009941 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 189918009942 [4Fe-4S] binding site [ion binding]; other site 189918009943 molybdopterin cofactor binding site; other site 189918009944 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 189918009945 molybdopterin cofactor binding site; other site 189918009946 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 189918009947 Flavodoxin; Region: Flavodoxin_1; pfam00258 189918009948 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 189918009949 FAD binding pocket [chemical binding]; other site 189918009950 FAD binding motif [chemical binding]; other site 189918009951 catalytic residues [active] 189918009952 NAD binding pocket [chemical binding]; other site 189918009953 phosphate binding motif [ion binding]; other site 189918009954 beta-alpha-beta structure motif; other site 189918009955 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 189918009956 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918009957 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 189918009958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918009959 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918009960 iron-sulfur cluster [ion binding]; other site 189918009961 [2Fe-2S] cluster binding site [ion binding]; other site 189918009962 PknH-like extracellular domain; Region: PknH_C; pfam14032 189918009963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918009964 Ligand Binding Site [chemical binding]; other site 189918009965 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 189918009966 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 189918009967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 189918009968 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 189918009969 PAS domain; Region: PAS; smart00091 189918009970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918009971 ATP binding site [chemical binding]; other site 189918009972 Mg2+ binding site [ion binding]; other site 189918009973 G-X-G motif; other site 189918009974 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 189918009975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918009976 active site 189918009977 phosphorylation site [posttranslational modification] 189918009978 intermolecular recognition site; other site 189918009979 dimerization interface [polypeptide binding]; other site 189918009980 Transcriptional regulator; Region: CitT; pfam12431 189918009981 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918009982 Cytochrome P450; Region: p450; cl12078 189918009983 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 189918009984 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 189918009985 putative active site [active] 189918009986 catalytic site [active] 189918009987 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 189918009988 putative active site [active] 189918009989 catalytic site [active] 189918009990 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918009991 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918009992 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 189918009993 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 189918009994 catalytic triad [active] 189918009995 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 189918009996 putative hydrophobic ligand binding site [chemical binding]; other site 189918009997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918009998 TIGR01777 family protein; Region: yfcH 189918009999 NAD(P) binding site [chemical binding]; other site 189918010000 active site 189918010001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918010002 active site 189918010003 DivIVA domain; Region: DivI1A_domain; TIGR03544 189918010004 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 189918010005 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 189918010006 Predicted integral membrane protein [Function unknown]; Region: COG0762 189918010007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 189918010008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 189918010009 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189918010010 catalytic residue [active] 189918010011 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 189918010012 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 189918010013 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 189918010014 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 189918010015 nucleotide binding site [chemical binding]; other site 189918010016 SulA interaction site; other site 189918010017 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 189918010018 Cell division protein FtsQ; Region: FtsQ; pfam03799 189918010019 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 189918010020 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 189918010021 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918010022 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918010023 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 189918010024 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 189918010025 active site 189918010026 homodimer interface [polypeptide binding]; other site 189918010027 cell division protein FtsW; Region: ftsW; TIGR02614 189918010028 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 189918010029 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918010030 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918010031 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 189918010032 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 189918010033 Mg++ binding site [ion binding]; other site 189918010034 putative catalytic motif [active] 189918010035 putative substrate binding site [chemical binding]; other site 189918010036 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 189918010037 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918010038 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918010039 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 189918010040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918010041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918010042 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 189918010043 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 189918010044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189918010045 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 189918010046 MraW methylase family; Region: Methyltransf_5; cl17771 189918010047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 189918010048 MraZ protein; Region: MraZ; pfam02381 189918010049 MraZ protein; Region: MraZ; pfam02381 189918010050 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 189918010051 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 189918010052 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 189918010053 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189918010054 substrate binding pocket [chemical binding]; other site 189918010055 chain length determination region; other site 189918010056 substrate-Mg2+ binding site; other site 189918010057 catalytic residues [active] 189918010058 aspartate-rich region 1; other site 189918010059 active site lid residues [active] 189918010060 aspartate-rich region 2; other site 189918010061 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 189918010062 Helix-turn-helix domain; Region: HTH_17; cl17695 189918010063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918010064 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918010065 active site 189918010066 ATP binding site [chemical binding]; other site 189918010067 substrate binding site [chemical binding]; other site 189918010068 activation loop (A-loop); other site 189918010069 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 189918010070 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 189918010071 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918010072 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189918010073 putative acyl-acceptor binding pocket; other site 189918010074 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 189918010075 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 189918010076 P loop; other site 189918010077 Nucleotide binding site [chemical binding]; other site 189918010078 DTAP/Switch II; other site 189918010079 Switch I; other site 189918010080 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918010081 putative hydrophobic ligand binding site [chemical binding]; other site 189918010082 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 189918010083 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189918010084 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189918010085 acyl-activating enzyme (AAE) consensus motif; other site 189918010086 putative AMP binding site [chemical binding]; other site 189918010087 putative active site [active] 189918010088 putative CoA binding site [chemical binding]; other site 189918010089 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 189918010090 agmatinase; Region: agmatinase; TIGR01230 189918010091 oligomer interface [polypeptide binding]; other site 189918010092 putative active site [active] 189918010093 Mn binding site [ion binding]; other site 189918010094 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 189918010095 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918010096 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918010097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918010098 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 189918010099 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 189918010100 NlpC/P60 family; Region: NLPC_P60; pfam00877 189918010101 hypothetical protein; Validated; Region: PRK07883 189918010102 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 189918010103 active site 189918010104 catalytic site [active] 189918010105 substrate binding site [chemical binding]; other site 189918010106 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 189918010107 GIY-YIG motif/motif A; other site 189918010108 active site 189918010109 catalytic site [active] 189918010110 putative DNA binding site [nucleotide binding]; other site 189918010111 metal binding site [ion binding]; metal-binding site 189918010112 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 189918010113 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 189918010114 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 189918010115 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 189918010116 Subunit I/III interface [polypeptide binding]; other site 189918010117 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 189918010118 Cytochrome c; Region: Cytochrom_C; pfam00034 189918010119 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 189918010120 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 189918010121 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 189918010122 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 189918010123 iron-sulfur cluster [ion binding]; other site 189918010124 [2Fe-2S] cluster binding site [ion binding]; other site 189918010125 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 189918010126 heme bH binding site [chemical binding]; other site 189918010127 intrachain domain interface; other site 189918010128 heme bL binding site [chemical binding]; other site 189918010129 interchain domain interface [polypeptide binding]; other site 189918010130 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 189918010131 Qo binding site; other site 189918010132 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 189918010133 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 189918010134 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 189918010135 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 189918010136 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 189918010137 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 189918010138 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 189918010139 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 189918010140 active site 189918010141 dimer interface [polypeptide binding]; other site 189918010142 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 189918010143 Ligand Binding Site [chemical binding]; other site 189918010144 Molecular Tunnel; other site 189918010145 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 189918010146 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 189918010147 substrate binding site [chemical binding]; other site 189918010148 ATP binding site [chemical binding]; other site 189918010149 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 189918010150 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 189918010151 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 189918010152 homotrimer interface [polypeptide binding]; other site 189918010153 Walker A motif; other site 189918010154 GTP binding site [chemical binding]; other site 189918010155 Walker B motif; other site 189918010156 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 189918010157 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 189918010158 putative dimer interface [polypeptide binding]; other site 189918010159 active site pocket [active] 189918010160 putative cataytic base [active] 189918010161 cobalamin synthase; Reviewed; Region: cobS; PRK00235 189918010162 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 189918010163 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 189918010164 homodimer interface [polypeptide binding]; other site 189918010165 substrate-cofactor binding pocket; other site 189918010166 catalytic residue [active] 189918010167 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 189918010168 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 189918010169 multifunctional aminopeptidase A; Provisional; Region: PRK00913 189918010170 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 189918010171 interface (dimer of trimers) [polypeptide binding]; other site 189918010172 Substrate-binding/catalytic site; other site 189918010173 Zn-binding sites [ion binding]; other site 189918010174 short chain dehydrogenase; Validated; Region: PRK05855 189918010175 classical (c) SDRs; Region: SDR_c; cd05233 189918010176 NAD(P) binding site [chemical binding]; other site 189918010177 active site 189918010178 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189918010179 E3 interaction surface; other site 189918010180 lipoyl attachment site [posttranslational modification]; other site 189918010181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189918010182 E3 interaction surface; other site 189918010183 lipoyl attachment site [posttranslational modification]; other site 189918010184 e3 binding domain; Region: E3_binding; pfam02817 189918010185 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 189918010186 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189918010187 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 189918010188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918010189 NAD(P) binding site [chemical binding]; other site 189918010190 active site 189918010191 lipoate-protein ligase B; Provisional; Region: PRK14345 189918010192 lipoyl synthase; Provisional; Region: PRK05481 189918010193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918010194 FeS/SAM binding site; other site 189918010195 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 189918010196 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 189918010197 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 189918010198 active site 189918010199 RDD family; Region: RDD; pfam06271 189918010200 glutamine synthetase, type I; Region: GlnA; TIGR00653 189918010201 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189918010202 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918010203 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 189918010204 putative active site [active] 189918010205 dimerization interface [polypeptide binding]; other site 189918010206 putative tRNAtyr binding site [nucleotide binding]; other site 189918010207 DoxX; Region: DoxX; pfam07681 189918010208 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918010209 B12 binding domain; Region: B12-binding_2; pfam02607 189918010210 B12 binding domain; Region: B12-binding; pfam02310 189918010211 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918010212 anti sigma factor interaction site; other site 189918010213 regulatory phosphorylation site [posttranslational modification]; other site 189918010214 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918010215 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918010216 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 189918010217 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 189918010218 metal binding triad; other site 189918010219 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 189918010220 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 189918010221 metal binding triad; other site 189918010222 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 189918010223 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 189918010224 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189918010225 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918010226 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189918010227 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918010228 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189918010229 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918010230 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918010231 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918010232 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918010233 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 189918010234 oligomerization interface [polypeptide binding]; other site 189918010235 active site 189918010236 metal binding site [ion binding]; metal-binding site 189918010237 enoyl-CoA hydratase; Provisional; Region: PRK06688 189918010238 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918010239 substrate binding site [chemical binding]; other site 189918010240 oxyanion hole (OAH) forming residues; other site 189918010241 trimer interface [polypeptide binding]; other site 189918010242 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 189918010243 putative active site; other site 189918010244 putative metal binding residues [ion binding]; other site 189918010245 signature motif; other site 189918010246 putative triphosphate binding site [ion binding]; other site 189918010247 CHAD domain; Region: CHAD; pfam05235 189918010248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918010249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918010250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918010251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 189918010252 RibD C-terminal domain; Region: RibD_C; cl17279 189918010253 CAAX protease self-immunity; Region: Abi; pfam02517 189918010254 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189918010255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918010256 S-adenosylmethionine binding site [chemical binding]; other site 189918010257 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 189918010258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918010259 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918010260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918010261 sequence-specific DNA binding site [nucleotide binding]; other site 189918010262 salt bridge; other site 189918010263 Cupin domain; Region: Cupin_2; pfam07883 189918010264 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 189918010265 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 189918010266 RNA/DNA hybrid binding site [nucleotide binding]; other site 189918010267 active site 189918010268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918010269 catalytic core [active] 189918010270 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 189918010271 Putative zinc ribbon domain; Region: DUF164; pfam02591 189918010272 Uncharacterized conserved protein [Function unknown]; Region: COG0327 189918010273 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 189918010274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 189918010275 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 189918010276 hypothetical protein; Provisional; Region: PRK07908 189918010277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918010278 homodimer interface [polypeptide binding]; other site 189918010279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918010280 catalytic residue [active] 189918010281 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 189918010282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918010283 motif II; other site 189918010284 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 189918010285 Low molecular weight phosphatase family; Region: LMWPc; cd00115 189918010286 active site 189918010287 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 189918010288 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 189918010289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918010290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918010291 DNA binding residues [nucleotide binding] 189918010292 dimerization interface [polypeptide binding]; other site 189918010293 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 189918010294 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 189918010295 glutaminase active site [active] 189918010296 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 189918010297 dimer interface [polypeptide binding]; other site 189918010298 active site 189918010299 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 189918010300 dimer interface [polypeptide binding]; other site 189918010301 active site 189918010302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918010303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918010304 NAD(P) binding site [chemical binding]; other site 189918010305 active site 189918010306 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 189918010307 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 189918010308 NodB motif; other site 189918010309 putative active site [active] 189918010310 putative catalytic site [active] 189918010311 putative Zn binding site [ion binding]; other site 189918010312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189918010313 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 189918010314 DXD motif; other site 189918010315 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 189918010316 putative sugar binding site [chemical binding]; other site 189918010317 catalytic residues [active] 189918010318 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 189918010319 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 189918010320 putative dimer interface [polypeptide binding]; other site 189918010321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918010322 ligand binding site [chemical binding]; other site 189918010323 Zn binding site [ion binding]; other site 189918010324 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918010325 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 189918010326 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 189918010327 dimer interface [polypeptide binding]; other site 189918010328 catalytic triad [active] 189918010329 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 189918010330 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 189918010331 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 189918010332 dimer interface [polypeptide binding]; other site 189918010333 TPP-binding site [chemical binding]; other site 189918010334 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 189918010335 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 189918010336 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918010337 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 189918010338 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918010339 acyl carrier protein; Provisional; Region: acpP; PRK00982 189918010340 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 189918010341 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 189918010342 dimer interface [polypeptide binding]; other site 189918010343 active site 189918010344 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 189918010345 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 189918010346 dimer interface [polypeptide binding]; other site 189918010347 active site 189918010348 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918010349 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918010350 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918010351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918010352 Ligand Binding Site [chemical binding]; other site 189918010353 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 189918010354 Spore germination protein; Region: Spore_permease; cl17796 189918010355 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 189918010356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918010357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918010358 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189918010359 FAD binding domain; Region: FAD_binding_4; pfam01565 189918010360 diacylglycerol kinase; Reviewed; Region: PRK11914 189918010361 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 189918010362 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 189918010363 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918010364 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918010365 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189918010366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918010367 S-adenosylmethionine binding site [chemical binding]; other site 189918010368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918010369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918010370 DNA binding residues [nucleotide binding] 189918010371 dimerization interface [polypeptide binding]; other site 189918010372 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 189918010373 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918010374 NAD binding site [chemical binding]; other site 189918010375 catalytic Zn binding site [ion binding]; other site 189918010376 substrate binding site [chemical binding]; other site 189918010377 structural Zn binding site [ion binding]; other site 189918010378 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918010379 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 189918010380 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 189918010381 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 189918010382 conserved cys residue [active] 189918010383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918010384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918010385 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 189918010386 DJ-1 family protein; Region: not_thiJ; TIGR01383 189918010387 conserved cys residue [active] 189918010388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918010389 nucleotide binding site [chemical binding]; other site 189918010390 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918010391 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918010392 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918010393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918010394 classical (c) SDRs; Region: SDR_c; cd05233 189918010395 NAD(P) binding site [chemical binding]; other site 189918010396 active site 189918010397 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 189918010398 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 189918010399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 189918010400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918010401 dimer interface [polypeptide binding]; other site 189918010402 conserved gate region; other site 189918010403 putative PBP binding loops; other site 189918010404 ABC-ATPase subunit interface; other site 189918010405 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 189918010406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918010407 putative PBP binding loops; other site 189918010408 dimer interface [polypeptide binding]; other site 189918010409 ABC-ATPase subunit interface; other site 189918010410 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 189918010411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918010412 Walker A/P-loop; other site 189918010413 ATP binding site [chemical binding]; other site 189918010414 Q-loop/lid; other site 189918010415 ABC transporter signature motif; other site 189918010416 Walker B; other site 189918010417 D-loop; other site 189918010418 H-loop/switch region; other site 189918010419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189918010420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918010421 Walker A/P-loop; other site 189918010422 ATP binding site [chemical binding]; other site 189918010423 Q-loop/lid; other site 189918010424 ABC transporter signature motif; other site 189918010425 Walker B; other site 189918010426 D-loop; other site 189918010427 H-loop/switch region; other site 189918010428 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918010429 classical (c) SDRs; Region: SDR_c; cd05233 189918010430 NAD(P) binding site [chemical binding]; other site 189918010431 active site 189918010432 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 189918010433 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918010434 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918010435 active site 189918010436 ATP binding site [chemical binding]; other site 189918010437 substrate binding site [chemical binding]; other site 189918010438 activation loop (A-loop); other site 189918010439 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918010440 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 189918010441 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 189918010442 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 189918010443 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 189918010444 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189918010445 RNA binding site [nucleotide binding]; other site 189918010446 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189918010447 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 189918010448 NAD binding site [chemical binding]; other site 189918010449 substrate binding site [chemical binding]; other site 189918010450 catalytic Zn binding site [ion binding]; other site 189918010451 structural Zn binding site [ion binding]; other site 189918010452 phosphoenolpyruvate synthase; Validated; Region: PRK06464 189918010453 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 189918010454 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 189918010455 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 189918010456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918010457 active site 189918010458 motif I; other site 189918010459 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 189918010460 motif II; other site 189918010461 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 189918010462 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 189918010463 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 189918010464 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 189918010465 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 189918010466 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 189918010467 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918010468 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918010469 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918010470 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918010471 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918010472 dimer interface [polypeptide binding]; other site 189918010473 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918010474 Ligand Binding Site [chemical binding]; other site 189918010475 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918010476 Ligand Binding Site [chemical binding]; other site 189918010477 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 189918010478 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 189918010479 putative substrate binding site [chemical binding]; other site 189918010480 putative ATP binding site [chemical binding]; other site 189918010481 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 189918010482 active site 189918010483 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 189918010484 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 189918010485 active site 189918010486 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 189918010487 nickel binding site [ion binding]; other site 189918010488 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 189918010489 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 189918010490 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 189918010491 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 189918010492 FAD binding pocket [chemical binding]; other site 189918010493 FAD binding motif [chemical binding]; other site 189918010494 phosphate binding motif [ion binding]; other site 189918010495 beta-alpha-beta structure motif; other site 189918010496 NAD binding pocket [chemical binding]; other site 189918010497 Iron coordination center [ion binding]; other site 189918010498 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 189918010499 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 189918010500 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189918010501 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189918010502 catalytic residue [active] 189918010503 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 189918010504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918010505 Cytochrome P450; Region: p450; cl12078 189918010506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918010507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918010508 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 189918010509 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918010510 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 189918010511 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 189918010512 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 189918010513 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918010514 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 189918010515 Walker A/P-loop; other site 189918010516 ATP binding site [chemical binding]; other site 189918010517 Q-loop/lid; other site 189918010518 ABC transporter signature motif; other site 189918010519 Walker B; other site 189918010520 D-loop; other site 189918010521 H-loop/switch region; other site 189918010522 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918010523 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918010524 Walker A/P-loop; other site 189918010525 ATP binding site [chemical binding]; other site 189918010526 Q-loop/lid; other site 189918010527 ABC transporter signature motif; other site 189918010528 Walker B; other site 189918010529 D-loop; other site 189918010530 H-loop/switch region; other site 189918010531 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918010532 MarR family; Region: MarR; pfam01047 189918010533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918010534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918010535 putative substrate translocation pore; other site 189918010536 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 189918010537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918010538 active site 189918010539 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 189918010540 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 189918010541 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 189918010542 D-pathway; other site 189918010543 Putative ubiquinol binding site [chemical binding]; other site 189918010544 Low-spin heme (heme b) binding site [chemical binding]; other site 189918010545 Putative water exit pathway; other site 189918010546 Binuclear center (heme o3/CuB) [ion binding]; other site 189918010547 K-pathway; other site 189918010548 Putative proton exit pathway; other site 189918010549 The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918 189918010550 DNA primase; Validated; Region: dnaG; PRK05667 189918010551 CHC2 zinc finger; Region: zf-CHC2; cl17510 189918010552 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 189918010553 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 189918010554 active site 189918010555 metal binding site [ion binding]; metal-binding site 189918010556 interdomain interaction site; other site 189918010557 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 189918010558 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 189918010559 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 189918010560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918010561 Zn2+ binding site [ion binding]; other site 189918010562 Mg2+ binding site [ion binding]; other site 189918010563 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 189918010564 Repair protein; Region: Repair_PSII; pfam04536 189918010565 glycyl-tRNA synthetase; Provisional; Region: PRK04173 189918010566 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189918010567 motif 1; other site 189918010568 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 189918010569 active site 189918010570 motif 2; other site 189918010571 motif 3; other site 189918010572 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 189918010573 anticodon binding site; other site 189918010574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918010575 dimerization interface [polypeptide binding]; other site 189918010576 putative DNA binding site [nucleotide binding]; other site 189918010577 putative Zn2+ binding site [ion binding]; other site 189918010578 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189918010579 metal binding site 2 [ion binding]; metal-binding site 189918010580 putative DNA binding helix; other site 189918010581 metal binding site 1 [ion binding]; metal-binding site 189918010582 dimer interface [polypeptide binding]; other site 189918010583 structural Zn2+ binding site [ion binding]; other site 189918010584 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 189918010585 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 189918010586 catalytic residue [active] 189918010587 putative FPP diphosphate binding site; other site 189918010588 putative FPP binding hydrophobic cleft; other site 189918010589 dimer interface [polypeptide binding]; other site 189918010590 putative IPP diphosphate binding site; other site 189918010591 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 189918010592 Recombination protein O N terminal; Region: RecO_N; pfam11967 189918010593 Recombination protein O C terminal; Region: RecO_C; pfam02565 189918010594 amidase; Provisional; Region: PRK06061 189918010595 Amidase; Region: Amidase; pfam01425 189918010596 GTPase Era; Reviewed; Region: era; PRK00089 189918010597 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 189918010598 G1 box; other site 189918010599 GTP/Mg2+ binding site [chemical binding]; other site 189918010600 Switch I region; other site 189918010601 G2 box; other site 189918010602 Switch II region; other site 189918010603 G3 box; other site 189918010604 G4 box; other site 189918010605 G5 box; other site 189918010606 KH domain; Region: KH_2; pfam07650 189918010607 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189918010608 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918010609 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918010610 Transporter associated domain; Region: CorC_HlyC; smart01091 189918010611 metal-binding heat shock protein; Provisional; Region: PRK00016 189918010612 K homology RNA-binding domain; Region: KH; smart00322 189918010613 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 189918010614 PhoH-like protein; Region: PhoH; pfam02562 189918010615 Protein of unknown function (DUF998); Region: DUF998; pfam06197 189918010616 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 189918010617 chaperone protein DnaJ; Provisional; Region: PRK14278 189918010618 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 189918010619 HSP70 interaction site [polypeptide binding]; other site 189918010620 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 189918010621 Zn binding sites [ion binding]; other site 189918010622 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 189918010623 dimer interface [polypeptide binding]; other site 189918010624 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 189918010625 HTH domain; Region: HTH_11; cl17392 189918010626 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 189918010627 MbtH-like protein; Region: MbtH; pfam03621 189918010628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918010629 Condensation domain; Region: Condensation; pfam00668 189918010630 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 189918010631 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 189918010632 acyl-activating enzyme (AAE) consensus motif; other site 189918010633 AMP binding site [chemical binding]; other site 189918010634 Condensation domain; Region: Condensation; pfam00668 189918010635 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 189918010636 Condensation domain; Region: Condensation; pfam00668 189918010637 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 189918010638 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 189918010639 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 189918010640 acyl-activating enzyme (AAE) consensus motif; other site 189918010641 AMP binding site [chemical binding]; other site 189918010642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918010643 Condensation domain; Region: Condensation; pfam00668 189918010644 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 189918010645 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 189918010646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918010647 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918010648 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918010649 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 189918010650 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 189918010651 NADP binding site [chemical binding]; other site 189918010652 active site 189918010653 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918010654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918010655 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918010656 active site 189918010657 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 189918010658 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 189918010659 Condensation domain; Region: Condensation; pfam00668 189918010660 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 189918010661 Nonribosomal peptide synthase; Region: NRPS; pfam08415 189918010662 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 189918010663 acyl-activating enzyme (AAE) consensus motif; other site 189918010664 AMP binding site [chemical binding]; other site 189918010665 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918010666 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 189918010667 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 189918010668 acyl-activating enzyme (AAE) consensus motif; other site 189918010669 active site 189918010670 AMP binding site [chemical binding]; other site 189918010671 substrate binding site [chemical binding]; other site 189918010672 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 189918010673 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918010674 active site 189918010675 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918010676 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 189918010677 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 189918010678 KR domain; Region: KR; pfam08659 189918010679 putative NADP binding site [chemical binding]; other site 189918010680 active site 189918010681 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918010682 coproporphyrinogen III oxidase; Validated; Region: PRK05628 189918010683 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 189918010684 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918010685 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189918010686 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 189918010687 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189918010688 Active Sites [active] 189918010689 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 189918010690 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 189918010691 putative active site [active] 189918010692 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 189918010693 putative active site [active] 189918010694 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918010695 FOG: CBS domain [General function prediction only]; Region: COG0517 189918010696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918010697 Transporter associated domain; Region: CorC_HlyC; pfam03471 189918010698 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189918010699 Domain of unknown function DUF21; Region: DUF21; pfam01595 189918010700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189918010701 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 189918010702 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 189918010703 Walker A/P-loop; other site 189918010704 ATP binding site [chemical binding]; other site 189918010705 Q-loop/lid; other site 189918010706 ABC transporter signature motif; other site 189918010707 Walker B; other site 189918010708 D-loop; other site 189918010709 H-loop/switch region; other site 189918010710 TOBE-like domain; Region: TOBE_3; pfam12857 189918010711 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189918010712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918010713 dimer interface [polypeptide binding]; other site 189918010714 conserved gate region; other site 189918010715 putative PBP binding loops; other site 189918010716 ABC-ATPase subunit interface; other site 189918010717 sulfate transport protein; Provisional; Region: cysT; CHL00187 189918010718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918010719 dimer interface [polypeptide binding]; other site 189918010720 conserved gate region; other site 189918010721 putative PBP binding loops; other site 189918010722 ABC-ATPase subunit interface; other site 189918010723 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 189918010724 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 189918010725 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 189918010726 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 189918010727 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918010728 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918010729 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 189918010730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918010731 active site 189918010732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918010733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918010734 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 189918010735 putative dimerization interface [polypeptide binding]; other site 189918010736 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 189918010737 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 189918010738 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 189918010739 PknH-like extracellular domain; Region: PknH_C; pfam14032 189918010740 PknH-like extracellular domain; Region: PknH_C; pfam14032 189918010741 GTP-binding protein LepA; Provisional; Region: PRK05433 189918010742 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 189918010743 G1 box; other site 189918010744 putative GEF interaction site [polypeptide binding]; other site 189918010745 GTP/Mg2+ binding site [chemical binding]; other site 189918010746 Switch I region; other site 189918010747 G2 box; other site 189918010748 G3 box; other site 189918010749 Switch II region; other site 189918010750 G4 box; other site 189918010751 G5 box; other site 189918010752 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 189918010753 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 189918010754 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 189918010755 PemK-like protein; Region: PemK; pfam02452 189918010756 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 189918010757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189918010758 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 189918010759 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 189918010760 polymerase nucleotide-binding site; other site 189918010761 DNA-binding residues [nucleotide binding]; DNA binding site 189918010762 nucleotide binding site [chemical binding]; other site 189918010763 primase nucleotide-binding site [nucleotide binding]; other site 189918010764 AAA domain; Region: AAA_25; pfam13481 189918010765 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189918010766 active site 189918010767 Int/Topo IB signature motif; other site 189918010768 DNA binding site [nucleotide binding] 189918010769 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 189918010770 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 189918010771 active site 189918010772 dimer interface [polypeptide binding]; other site 189918010773 non-prolyl cis peptide bond; other site 189918010774 insertion regions; other site 189918010775 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918010776 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 189918010777 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 189918010778 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 189918010779 Walker A/P-loop; other site 189918010780 ATP binding site [chemical binding]; other site 189918010781 Q-loop/lid; other site 189918010782 ABC transporter signature motif; other site 189918010783 Walker B; other site 189918010784 D-loop; other site 189918010785 H-loop/switch region; other site 189918010786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918010787 dimer interface [polypeptide binding]; other site 189918010788 conserved gate region; other site 189918010789 ABC-ATPase subunit interface; other site 189918010790 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 189918010791 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 189918010792 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 189918010793 active site 189918010794 non-prolyl cis peptide bond; other site 189918010795 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 189918010796 ribonuclease Z; Reviewed; Region: PRK00055 189918010797 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 189918010798 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 189918010799 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 189918010800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 189918010801 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 189918010802 Uncharacterized conserved protein [Function unknown]; Region: COG2308 189918010803 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 189918010804 hypothetical protein; Reviewed; Region: PRK07914 189918010805 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 189918010806 Competence protein; Region: Competence; pfam03772 189918010807 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 189918010808 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 189918010809 polymerase nucleotide-binding site; other site 189918010810 DNA-binding residues [nucleotide binding]; DNA binding site 189918010811 nucleotide binding site [chemical binding]; other site 189918010812 primase nucleotide-binding site [nucleotide binding]; other site 189918010813 AAA domain; Region: AAA_25; pfam13481 189918010814 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 189918010815 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 189918010816 catalytic residues [active] 189918010817 catalytic nucleophile [active] 189918010818 Recombinase; Region: Recombinase; pfam07508 189918010819 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 189918010820 SLBB domain; Region: SLBB; pfam10531 189918010821 Helix-hairpin-helix motif; Region: HHH; pfam00633 189918010822 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 189918010823 homotrimer interaction site [polypeptide binding]; other site 189918010824 putative active site [active] 189918010825 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918010826 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918010827 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918010828 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918010829 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 189918010830 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 189918010831 putative hydrophobic ligand binding site [chemical binding]; other site 189918010832 CLM binding site; other site 189918010833 L1 loop; other site 189918010834 DNA binding site [nucleotide binding] 189918010835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918010836 putative DNA binding site [nucleotide binding]; other site 189918010837 putative Zn2+ binding site [ion binding]; other site 189918010838 EDD domain protein, DegV family; Region: DegV; TIGR00762 189918010839 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 189918010840 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189918010841 active site 189918010842 catalytic triad [active] 189918010843 oxyanion hole [active] 189918010844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918010845 catalytic core [active] 189918010846 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 189918010847 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 189918010848 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 189918010849 active site 189918010850 (T/H)XGH motif; other site 189918010851 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 189918010852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918010853 DNA-binding site [nucleotide binding]; DNA binding site 189918010854 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 189918010855 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 189918010856 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 189918010857 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918010858 nucleotide binding site [chemical binding]; other site 189918010859 Predicted dehydrogenase [General function prediction only]; Region: COG0579 189918010860 hydroxyglutarate oxidase; Provisional; Region: PRK11728 189918010861 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 189918010862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918010863 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 189918010864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 189918010865 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 189918010866 metal ion-dependent adhesion site (MIDAS); other site 189918010867 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918010868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918010869 Walker A motif; other site 189918010870 ATP binding site [chemical binding]; other site 189918010871 Walker B motif; other site 189918010872 arginine finger; other site 189918010873 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 189918010874 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 189918010875 putative catalytic cysteine [active] 189918010876 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 189918010877 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 189918010878 substrate binding site [chemical binding]; other site 189918010879 dimer interface [polypeptide binding]; other site 189918010880 ATP binding site [chemical binding]; other site 189918010881 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918010882 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918010883 substrate binding site [chemical binding]; other site 189918010884 oxyanion hole (OAH) forming residues; other site 189918010885 trimer interface [polypeptide binding]; other site 189918010886 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918010887 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918010888 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918010889 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918010890 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918010891 active site 189918010892 NAD synthetase; Reviewed; Region: nadE; PRK02628 189918010893 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 189918010894 multimer interface [polypeptide binding]; other site 189918010895 active site 189918010896 catalytic triad [active] 189918010897 protein interface 1 [polypeptide binding]; other site 189918010898 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 189918010899 homodimer interface [polypeptide binding]; other site 189918010900 NAD binding pocket [chemical binding]; other site 189918010901 ATP binding pocket [chemical binding]; other site 189918010902 Mg binding site [ion binding]; other site 189918010903 active-site loop [active] 189918010904 Isochorismatase family; Region: Isochorismatase; pfam00857 189918010905 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 189918010906 catalytic triad [active] 189918010907 conserved cis-peptide bond; other site 189918010908 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 189918010909 NAD-dependent deacetylase; Provisional; Region: PRK05333 189918010910 NAD+ binding site [chemical binding]; other site 189918010911 substrate binding site [chemical binding]; other site 189918010912 Zn binding site [ion binding]; other site 189918010913 gamma-glutamyl kinase; Provisional; Region: PRK05429 189918010914 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 189918010915 nucleotide binding site [chemical binding]; other site 189918010916 homotetrameric interface [polypeptide binding]; other site 189918010917 putative phosphate binding site [ion binding]; other site 189918010918 putative allosteric binding site; other site 189918010919 PUA domain; Region: PUA; pfam01472 189918010920 GTPase CgtA; Reviewed; Region: obgE; PRK12296 189918010921 GTP1/OBG; Region: GTP1_OBG; pfam01018 189918010922 Obg GTPase; Region: Obg; cd01898 189918010923 G1 box; other site 189918010924 GTP/Mg2+ binding site [chemical binding]; other site 189918010925 Switch I region; other site 189918010926 G2 box; other site 189918010927 G3 box; other site 189918010928 Switch II region; other site 189918010929 G4 box; other site 189918010930 G5 box; other site 189918010931 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 189918010932 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 189918010933 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 189918010934 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 189918010935 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 189918010936 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 189918010937 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 189918010938 homodimer interface [polypeptide binding]; other site 189918010939 oligonucleotide binding site [chemical binding]; other site 189918010940 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 189918010941 active site 189918010942 multimer interface [polypeptide binding]; other site 189918010943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918010944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918010945 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 189918010946 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 189918010947 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 189918010948 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918010949 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918010950 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 189918010951 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 189918010952 active site 189918010953 HIGH motif; other site 189918010954 nucleotide binding site [chemical binding]; other site 189918010955 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 189918010956 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 189918010957 active site 189918010958 KMSKS motif; other site 189918010959 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 189918010960 tRNA binding surface [nucleotide binding]; other site 189918010961 anticodon binding site; other site 189918010962 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 189918010963 Uncharacterized conserved protein [Function unknown]; Region: COG3268 189918010964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918010965 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 189918010966 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189918010967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918010968 hypothetical protein; Provisional; Region: PRK06753 189918010969 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918010970 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918010971 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918010972 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 189918010973 GTP binding site; other site 189918010974 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 189918010975 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 189918010976 TPP-binding site [chemical binding]; other site 189918010977 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 189918010978 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 189918010979 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 189918010980 dimer interface [polypeptide binding]; other site 189918010981 PYR/PP interface [polypeptide binding]; other site 189918010982 TPP binding site [chemical binding]; other site 189918010983 substrate binding site [chemical binding]; other site 189918010984 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918010985 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918010986 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918010987 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918010988 [2Fe-2S] cluster binding site [ion binding]; other site 189918010989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 189918010990 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189918010991 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 189918010992 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 189918010993 active site 189918010994 TDP-binding site; other site 189918010995 acceptor substrate-binding pocket; other site 189918010996 homodimer interface [polypeptide binding]; other site 189918010997 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 189918010998 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 189918010999 iron-sulfur cluster [ion binding]; other site 189918011000 [2Fe-2S] cluster binding site [ion binding]; other site 189918011001 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 189918011002 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 189918011003 putative di-iron ligands [ion binding]; other site 189918011004 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 189918011005 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 189918011006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918011007 Walker A motif; other site 189918011008 ATP binding site [chemical binding]; other site 189918011009 Walker B motif; other site 189918011010 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 189918011011 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 189918011012 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 189918011013 oligomer interface [polypeptide binding]; other site 189918011014 active site residues [active] 189918011015 Clp protease; Region: CLP_protease; pfam00574 189918011016 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 189918011017 oligomer interface [polypeptide binding]; other site 189918011018 active site residues [active] 189918011019 trigger factor; Provisional; Region: tig; PRK01490 189918011020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 189918011021 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 189918011022 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 189918011023 hypothetical protein; Provisional; Region: PRK07208 189918011024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918011025 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 189918011026 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 189918011027 catalytic residue [active] 189918011028 putative FPP diphosphate binding site; other site 189918011029 putative FPP binding hydrophobic cleft; other site 189918011030 dimer interface [polypeptide binding]; other site 189918011031 putative IPP diphosphate binding site; other site 189918011032 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 189918011033 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189918011034 GAF domain; Region: GAF; pfam01590 189918011035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918011036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918011037 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189918011038 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 189918011039 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 189918011040 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 189918011041 putative ADP-binding pocket [chemical binding]; other site 189918011042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918011043 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 189918011044 FHIPEP family; Region: FHIPEP; cl07980 189918011045 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 189918011046 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 189918011047 putative [4Fe-4S] binding site [ion binding]; other site 189918011048 putative molybdopterin cofactor binding site [chemical binding]; other site 189918011049 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 189918011050 molybdopterin cofactor binding site; other site 189918011051 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918011052 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918011053 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 189918011054 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 189918011055 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 189918011056 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 189918011057 putative DNA binding site [nucleotide binding]; other site 189918011058 catalytic residue [active] 189918011059 putative H2TH interface [polypeptide binding]; other site 189918011060 putative catalytic residues [active] 189918011061 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 189918011062 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 189918011063 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 189918011064 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 189918011065 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 189918011066 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 189918011067 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 189918011068 nucleoside/Zn binding site; other site 189918011069 dimer interface [polypeptide binding]; other site 189918011070 catalytic motif [active] 189918011071 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189918011072 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189918011073 acyl-activating enzyme (AAE) consensus motif; other site 189918011074 putative AMP binding site [chemical binding]; other site 189918011075 putative active site [active] 189918011076 putative CoA binding site [chemical binding]; other site 189918011077 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 189918011078 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 189918011079 catalytic residues [active] 189918011080 N-formylglutamate amidohydrolase; Region: FGase; cl01522 189918011081 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918011082 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 189918011083 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 189918011084 Zn binding site [ion binding]; other site 189918011085 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918011086 active site 189918011087 Domain of unknown function (DUF477); Region: DUF477; cl01535 189918011088 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 189918011089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918011090 active site 189918011091 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 189918011092 apolar tunnel; other site 189918011093 heme binding site [chemical binding]; other site 189918011094 dimerization interface [polypeptide binding]; other site 189918011095 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 189918011096 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 189918011097 active site 189918011098 catalytic site [active] 189918011099 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 189918011100 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189918011101 active site 189918011102 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 189918011103 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 189918011104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918011105 Walker A/P-loop; other site 189918011106 ATP binding site [chemical binding]; other site 189918011107 Q-loop/lid; other site 189918011108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918011109 ABC transporter; Region: ABC_tran_2; pfam12848 189918011110 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918011111 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 189918011112 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 189918011113 dimer interface [polypeptide binding]; other site 189918011114 ssDNA binding site [nucleotide binding]; other site 189918011115 tetramer (dimer of dimers) interface [polypeptide binding]; other site 189918011116 Copper resistance protein D; Region: CopD; pfam05425 189918011117 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 189918011118 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 189918011119 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 189918011120 putative acyl-acceptor binding pocket; other site 189918011121 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 189918011122 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 189918011123 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918011124 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189918011125 putative acyl-acceptor binding pocket; other site 189918011126 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918011127 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918011128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918011129 Ligand Binding Site [chemical binding]; other site 189918011130 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918011131 Ligand Binding Site [chemical binding]; other site 189918011132 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 189918011133 enoyl-CoA hydratase; Provisional; Region: PRK05870 189918011134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918011135 substrate binding site [chemical binding]; other site 189918011136 oxyanion hole (OAH) forming residues; other site 189918011137 trimer interface [polypeptide binding]; other site 189918011138 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 189918011139 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189918011140 E3 interaction surface; other site 189918011141 lipoyl attachment site [posttranslational modification]; other site 189918011142 e3 binding domain; Region: E3_binding; pfam02817 189918011143 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189918011144 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 189918011145 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 189918011146 alpha subunit interface [polypeptide binding]; other site 189918011147 TPP binding site [chemical binding]; other site 189918011148 heterodimer interface [polypeptide binding]; other site 189918011149 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189918011150 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 189918011151 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 189918011152 tetramer interface [polypeptide binding]; other site 189918011153 TPP-binding site [chemical binding]; other site 189918011154 heterodimer interface [polypeptide binding]; other site 189918011155 phosphorylation loop region [posttranslational modification] 189918011156 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 189918011157 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 189918011158 putative active site [active] 189918011159 putative catalytic site [active] 189918011160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011162 active site 189918011163 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 189918011164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918011165 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 189918011166 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 189918011167 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918011168 carboxyltransferase (CT) interaction site; other site 189918011169 biotinylation site [posttranslational modification]; other site 189918011170 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 189918011171 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918011172 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918011173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918011176 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918011177 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 189918011178 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 189918011179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011180 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918011181 classical (c) SDRs; Region: SDR_c; cd05233 189918011182 NAD(P) binding site [chemical binding]; other site 189918011183 active site 189918011184 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 189918011185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189918011186 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 189918011187 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 189918011188 catalytic site [active] 189918011189 putative active site [active] 189918011190 putative substrate binding site [chemical binding]; other site 189918011191 dimer interface [polypeptide binding]; other site 189918011192 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 189918011193 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 189918011194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 189918011195 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 189918011196 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 189918011197 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 189918011198 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918011199 catalytic triad [active] 189918011200 hypothetical protein; Provisional; Region: PRK07907 189918011201 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 189918011202 active site 189918011203 metal binding site [ion binding]; metal-binding site 189918011204 dimer interface [polypeptide binding]; other site 189918011205 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 189918011206 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 189918011207 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 189918011208 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 189918011209 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 189918011210 phosphate binding site [ion binding]; other site 189918011211 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 189918011212 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 189918011213 putative active site [active] 189918011214 putative catalytic site [active] 189918011215 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 189918011216 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918011217 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 189918011218 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 189918011219 putative NAD(P) binding site [chemical binding]; other site 189918011220 active site 189918011221 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 189918011222 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 189918011223 active site 189918011224 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 189918011225 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 189918011226 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918011227 DNA binding residues [nucleotide binding] 189918011228 putative dimer interface [polypeptide binding]; other site 189918011229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918011231 putative substrate translocation pore; other site 189918011232 ChaB; Region: ChaB; pfam06150 189918011233 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 189918011234 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 189918011235 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 189918011236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011237 acyl-activating enzyme (AAE) consensus motif; other site 189918011238 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 189918011239 putative AMP binding site [chemical binding]; other site 189918011240 putative active site [active] 189918011241 acyl-activating enzyme (AAE) consensus motif; other site 189918011242 putative CoA binding site [chemical binding]; other site 189918011243 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918011244 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 189918011245 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011246 acyl-activating enzyme (AAE) consensus motif; other site 189918011247 AMP binding site [chemical binding]; other site 189918011248 active site 189918011249 CoA binding site [chemical binding]; other site 189918011250 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918011251 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918011252 substrate binding site [chemical binding]; other site 189918011253 oxyanion hole (OAH) forming residues; other site 189918011254 trimer interface [polypeptide binding]; other site 189918011255 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918011256 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918011257 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 189918011258 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918011259 active site 189918011260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011262 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011263 Cytochrome P450; Region: p450; cl12078 189918011264 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918011265 mce related protein; Region: MCE; pfam02470 189918011266 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918011267 mce related protein; Region: MCE; pfam02470 189918011268 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918011269 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918011270 mce related protein; Region: MCE; pfam02470 189918011271 mce related protein; Region: MCE; pfam02470 189918011272 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918011273 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918011274 mce related protein; Region: MCE; pfam02470 189918011275 mce related protein; Region: MCE; pfam02470 189918011276 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918011277 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918011278 Permease; Region: Permease; pfam02405 189918011279 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918011280 Permease; Region: Permease; pfam02405 189918011281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918011282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918011283 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 189918011284 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 189918011285 NAD binding site [chemical binding]; other site 189918011286 catalytic residues [active] 189918011287 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918011288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011289 NAD(P) binding site [chemical binding]; other site 189918011290 active site 189918011291 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918011292 classical (c) SDRs; Region: SDR_c; cd05233 189918011293 NAD(P) binding site [chemical binding]; other site 189918011294 active site 189918011295 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 189918011296 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011297 Cytochrome P450; Region: p450; cl12078 189918011298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011300 active site 189918011301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011302 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918011303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011304 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918011305 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918011306 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918011307 iron-sulfur cluster [ion binding]; other site 189918011308 [2Fe-2S] cluster binding site [ion binding]; other site 189918011309 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918011310 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 189918011311 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 189918011312 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 189918011313 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 189918011314 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918011315 lipid-transfer protein; Provisional; Region: PRK07855 189918011316 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918011317 active site 189918011318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918011319 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918011320 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 189918011321 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 189918011322 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918011323 Cytochrome P450; Region: p450; cl12078 189918011324 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011325 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918011326 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918011327 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011328 Cytochrome P450; Region: p450; cl12078 189918011329 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 189918011330 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918011331 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918011332 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918011333 [2Fe-2S] cluster binding site [ion binding]; other site 189918011334 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 189918011335 putative alpha subunit interface [polypeptide binding]; other site 189918011336 putative active site [active] 189918011337 putative substrate binding site [chemical binding]; other site 189918011338 Fe binding site [ion binding]; other site 189918011339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011341 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 189918011342 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918011343 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918011344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011345 Cytochrome P450; Region: p450; cl12078 189918011346 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918011347 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918011348 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 189918011349 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 189918011350 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918011351 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918011352 [2Fe-2S] cluster binding site [ion binding]; other site 189918011353 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 189918011354 alpha subunit interface [polypeptide binding]; other site 189918011355 active site 189918011356 substrate binding site [chemical binding]; other site 189918011357 Fe binding site [ion binding]; other site 189918011358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918011359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011360 NAD(P) binding site [chemical binding]; other site 189918011361 active site 189918011362 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 189918011363 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 189918011364 FAD binding pocket [chemical binding]; other site 189918011365 FAD binding motif [chemical binding]; other site 189918011366 phosphate binding motif [ion binding]; other site 189918011367 beta-alpha-beta structure motif; other site 189918011368 NAD(p) ribose binding residues [chemical binding]; other site 189918011369 NAD binding pocket [chemical binding]; other site 189918011370 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 189918011371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918011372 catalytic loop [active] 189918011373 iron binding site [ion binding]; other site 189918011374 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918011375 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 189918011376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918011377 MarR family; Region: MarR_2; pfam12802 189918011378 MarR family; Region: MarR_2; cl17246 189918011379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918011380 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 189918011381 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 189918011382 active site 189918011383 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918011384 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918011385 [2Fe-2S] cluster binding site [ion binding]; other site 189918011386 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 189918011387 alpha subunit interface [polypeptide binding]; other site 189918011388 active site 189918011389 substrate binding site [chemical binding]; other site 189918011390 Fe binding site [ion binding]; other site 189918011391 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 189918011392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918011393 NAD binding site [chemical binding]; other site 189918011394 catalytic residues [active] 189918011395 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 189918011396 Winged helix-turn helix; Region: HTH_29; pfam13551 189918011397 Integrase core domain; Region: rve; pfam00665 189918011398 Integrase core domain; Region: rve_3; pfam13683 189918011399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011400 Cytochrome P450; Region: p450; cl12078 189918011401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918011406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918011407 Walker A motif; other site 189918011408 ATP binding site [chemical binding]; other site 189918011409 Walker B motif; other site 189918011410 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 189918011411 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 189918011412 metal ion-dependent adhesion site (MIDAS); other site 189918011413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918011414 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918011415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011416 NAD(P) binding site [chemical binding]; other site 189918011417 active site 189918011418 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 189918011419 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918011420 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918011421 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918011422 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918011423 active site 189918011424 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 189918011425 dimer interface [polypeptide binding]; other site 189918011426 substrate binding site [chemical binding]; other site 189918011427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011429 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011430 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011431 active site 189918011432 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918011433 putative active site [active] 189918011434 putative substrate binding site [chemical binding]; other site 189918011435 ATP binding site [chemical binding]; other site 189918011436 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 189918011437 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918011438 NAD(P) binding site [chemical binding]; other site 189918011439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011442 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011443 active site 189918011444 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 189918011445 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918011446 dimer interface [polypeptide binding]; other site 189918011447 active site 189918011448 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918011449 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918011450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918011451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011452 NAD(P) binding site [chemical binding]; other site 189918011453 active site 189918011454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011456 active site 189918011457 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918011458 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918011459 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918011460 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918011461 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918011462 [2Fe-2S] cluster binding site [ion binding]; other site 189918011463 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 189918011464 alpha subunit interface [polypeptide binding]; other site 189918011465 active site 189918011466 substrate binding site [chemical binding]; other site 189918011467 Fe binding site [ion binding]; other site 189918011468 Herpesvirus VP23 like capsid protein; Region: Herpes_V23; cl17653 189918011469 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 189918011470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918011471 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 189918011472 active site 189918011473 SnoaL-like domain; Region: SnoaL_4; pfam13577 189918011474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011476 active site 189918011477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011479 enoyl-CoA hydratase; Provisional; Region: PRK08290 189918011480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918011481 substrate binding site [chemical binding]; other site 189918011482 oxyanion hole (OAH) forming residues; other site 189918011483 trimer interface [polypeptide binding]; other site 189918011484 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011485 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011486 active site 189918011487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011489 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 189918011490 classical (c) SDRs; Region: SDR_c; cd05233 189918011491 NAD(P) binding site [chemical binding]; other site 189918011492 active site 189918011493 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918011494 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918011495 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918011496 acyl-CoA synthetase; Provisional; Region: PRK13382 189918011497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011498 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918011499 acyl-activating enzyme (AAE) consensus motif; other site 189918011500 putative AMP binding site [chemical binding]; other site 189918011501 putative active site [active] 189918011502 putative CoA binding site [chemical binding]; other site 189918011503 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918011504 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918011505 putative acyl-acceptor binding pocket; other site 189918011506 extended (e) SDRs; Region: SDR_e; cd08946 189918011507 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189918011508 NAD(P) binding site [chemical binding]; other site 189918011509 active site 189918011510 substrate binding site [chemical binding]; other site 189918011511 classical (c) SDRs; Region: SDR_c; cd05233 189918011512 NAD(P) binding site [chemical binding]; other site 189918011513 active site 189918011514 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918011515 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918011516 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918011517 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918011518 enoyl-CoA hydratase; Provisional; Region: PRK12478 189918011519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918011520 substrate binding site [chemical binding]; other site 189918011521 oxyanion hole (OAH) forming residues; other site 189918011522 trimer interface [polypeptide binding]; other site 189918011523 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 189918011524 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 189918011525 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 189918011526 active site 189918011527 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 189918011528 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 189918011529 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 189918011530 active site 189918011531 Amidohydrolase; Region: Amidohydro_2; pfam04909 189918011532 Cytochrome P450; Region: p450; cl12078 189918011533 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011534 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918011535 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 189918011536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011539 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 189918011540 NAD(P) binding site [chemical binding]; other site 189918011541 active site 189918011542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918011543 TAP-like protein; Region: Abhydrolase_4; pfam08386 189918011544 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 189918011545 Methyltransferase domain; Region: Methyltransf_26; pfam13659 189918011546 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 189918011547 oligomeric interface; other site 189918011548 putative active site [active] 189918011549 homodimer interface [polypeptide binding]; other site 189918011550 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 189918011551 GIY-YIG motif/motif A; other site 189918011552 putative active site [active] 189918011553 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 189918011554 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 189918011555 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 189918011556 DEAD-like helicases superfamily; Region: DEXDc; smart00487 189918011557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918011558 ATP binding site [chemical binding]; other site 189918011559 putative Mg++ binding site [ion binding]; other site 189918011560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 189918011561 nucleotide binding region [chemical binding]; other site 189918011562 ATP-binding site [chemical binding]; other site 189918011563 Predicted flavoprotein [General function prediction only]; Region: COG0431 189918011564 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189918011565 Putative cyclase; Region: Cyclase; pfam04199 189918011566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918011567 NAD(P) binding site [chemical binding]; other site 189918011568 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 189918011569 active site 189918011570 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 189918011571 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 189918011572 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 189918011573 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918011574 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 189918011575 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 189918011576 active site 189918011577 metal binding site [ion binding]; metal-binding site 189918011578 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 189918011579 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918011580 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918011581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918011582 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 189918011583 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918011584 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 189918011585 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 189918011586 L-aspartate oxidase; Provisional; Region: PRK06175 189918011587 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918011588 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 189918011589 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 189918011590 Subunit I/III interface [polypeptide binding]; other site 189918011591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011593 LAO/AO transport system ATPase; Region: lao; TIGR00750 189918011594 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918011595 putative acyltransferase; Provisional; Region: PRK05790 189918011596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918011597 dimer interface [polypeptide binding]; other site 189918011598 active site 189918011599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011600 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 189918011601 NAD(P) binding site [chemical binding]; other site 189918011602 active site 189918011603 short chain dehydrogenase; Provisional; Region: PRK08278 189918011604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011605 NAD(P) binding site [chemical binding]; other site 189918011606 active site 189918011607 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 189918011608 active site 189918011609 Trp repressor protein; Region: Trp_repressor; cl17266 189918011610 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 189918011611 Phage capsid family; Region: Phage_capsid; pfam05065 189918011612 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 189918011613 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 189918011614 GIY-YIG motif/motif A; other site 189918011615 active site 189918011616 catalytic site [active] 189918011617 metal binding site [ion binding]; metal-binding site 189918011618 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 189918011619 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 189918011620 catalytic residues [active] 189918011621 catalytic nucleophile [active] 189918011622 Recombinase; Region: Recombinase; pfam07508 189918011623 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 189918011624 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918011625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918011626 substrate binding site [chemical binding]; other site 189918011627 oxyanion hole (OAH) forming residues; other site 189918011628 trimer interface [polypeptide binding]; other site 189918011629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011631 active site 189918011632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918011633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918011634 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918011635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011636 acyl-activating enzyme (AAE) consensus motif; other site 189918011637 AMP binding site [chemical binding]; other site 189918011638 active site 189918011639 CoA binding site [chemical binding]; other site 189918011640 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918011641 catalytic loop [active] 189918011642 iron binding site [ion binding]; other site 189918011643 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918011644 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918011645 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 189918011646 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918011647 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 189918011648 B12 binding site [chemical binding]; other site 189918011649 cobalt ligand [ion binding]; other site 189918011650 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 189918011651 short chain dehydrogenase; Provisional; Region: PRK08278 189918011652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918011653 NAD(P) binding site [chemical binding]; other site 189918011654 active site 189918011655 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918011656 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011658 acyl-activating enzyme (AAE) consensus motif; other site 189918011659 acyl-activating enzyme (AAE) consensus motif; other site 189918011660 AMP binding site [chemical binding]; other site 189918011661 active site 189918011662 CoA binding site [chemical binding]; other site 189918011663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918011664 dimerization interface [polypeptide binding]; other site 189918011665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918011666 cyclase homology domain; Region: CHD; cd07302 189918011667 nucleotidyl binding site; other site 189918011668 metal binding site [ion binding]; metal-binding site 189918011669 dimer interface [polypeptide binding]; other site 189918011670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011671 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918011672 putative substrate translocation pore; other site 189918011673 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918011674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011675 putative substrate translocation pore; other site 189918011676 Phosphotransferase enzyme family; Region: APH; pfam01636 189918011677 Ecdysteroid kinase; Region: EcKinase; cl17738 189918011678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918011679 Cytochrome P450; Region: p450; cl12078 189918011680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 189918011681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 189918011682 DNA binding site [nucleotide binding] 189918011683 domain linker motif; other site 189918011684 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 189918011685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011686 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918011687 putative substrate translocation pore; other site 189918011688 Domain of unknown function (DUF309); Region: DUF309; pfam03745 189918011689 Predicted membrane protein [Function unknown]; Region: COG4270 189918011690 Glucitol operon activator protein (GutM); Region: GutM; cl01890 189918011691 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 189918011692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918011693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011695 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918011696 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 189918011697 active site 189918011698 dimerization interface [polypeptide binding]; other site 189918011699 ribonuclease PH; Reviewed; Region: rph; PRK00173 189918011700 Ribonuclease PH; Region: RNase_PH_bact; cd11362 189918011701 hexamer interface [polypeptide binding]; other site 189918011702 active site 189918011703 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 189918011704 glutamate racemase; Provisional; Region: PRK00865 189918011705 Rhomboid family; Region: Rhomboid; pfam01694 189918011706 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 189918011707 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189918011708 dimer interface [polypeptide binding]; other site 189918011709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918011710 catalytic residue [active] 189918011711 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 189918011712 MoaE interaction surface [polypeptide binding]; other site 189918011713 MoeB interaction surface [polypeptide binding]; other site 189918011714 thiocarboxylated glycine; other site 189918011715 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 189918011716 MPN+ (JAMM) motif; other site 189918011717 Zinc-binding site [ion binding]; other site 189918011718 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 189918011719 putative active site pocket [active] 189918011720 cleavage site 189918011721 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 189918011722 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 189918011723 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 189918011724 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 189918011725 active site 189918011726 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 189918011727 DEAD/DEAH box helicase; Region: DEAD; pfam00270 189918011728 DEAD_2; Region: DEAD_2; pfam06733 189918011729 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 189918011730 Predicted metalloprotease [General function prediction only]; Region: COG2321 189918011731 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 189918011732 MspA; Region: MspA; pfam09203 189918011733 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 189918011734 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 189918011735 putative homodimer interface [polypeptide binding]; other site 189918011736 putative active site pocket [active] 189918011737 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 189918011738 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 189918011739 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 189918011740 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 189918011741 active site 189918011742 homodimer interface [polypeptide binding]; other site 189918011743 catalytic site [active] 189918011744 acceptor binding site [chemical binding]; other site 189918011745 glycogen branching enzyme; Provisional; Region: PRK05402 189918011746 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 189918011747 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 189918011748 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 189918011749 active site 189918011750 catalytic site [active] 189918011751 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 189918011752 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 189918011753 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 189918011754 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 189918011755 putative acyltransferase; Provisional; Region: PRK05790 189918011756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918011757 dimer interface [polypeptide binding]; other site 189918011758 active site 189918011759 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 189918011760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918011761 dimer interface [polypeptide binding]; other site 189918011762 substrate binding site [chemical binding]; other site 189918011763 metal binding site [ion binding]; metal-binding site 189918011764 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 189918011765 hypothetical protein; Provisional; Region: PRK03298 189918011766 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189918011767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918011768 dimerization interface [polypeptide binding]; other site 189918011769 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918011770 cyclase homology domain; Region: CHD; cd07302 189918011771 nucleotidyl binding site; other site 189918011772 metal binding site [ion binding]; metal-binding site 189918011773 dimer interface [polypeptide binding]; other site 189918011774 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 189918011775 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918011776 acyl-activating enzyme (AAE) consensus motif; other site 189918011777 active site 189918011778 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 189918011779 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 189918011780 AlkA N-terminal domain; Region: AlkA_N; pfam06029 189918011781 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 189918011782 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189918011783 minor groove reading motif; other site 189918011784 helix-hairpin-helix signature motif; other site 189918011785 substrate binding pocket [chemical binding]; other site 189918011786 active site 189918011787 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 189918011788 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 189918011789 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 189918011790 DNA binding site [nucleotide binding] 189918011791 active site 189918011792 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 189918011793 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 189918011794 hinge; other site 189918011795 active site 189918011796 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 189918011797 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 189918011798 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 189918011799 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 189918011800 gamma subunit interface [polypeptide binding]; other site 189918011801 epsilon subunit interface [polypeptide binding]; other site 189918011802 LBP interface [polypeptide binding]; other site 189918011803 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 189918011804 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 189918011805 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 189918011806 alpha subunit interaction interface [polypeptide binding]; other site 189918011807 Walker A motif; other site 189918011808 ATP binding site [chemical binding]; other site 189918011809 Walker B motif; other site 189918011810 inhibitor binding site; inhibition site 189918011811 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 189918011812 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 189918011813 core domain interface [polypeptide binding]; other site 189918011814 delta subunit interface [polypeptide binding]; other site 189918011815 epsilon subunit interface [polypeptide binding]; other site 189918011816 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 189918011817 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 189918011818 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 189918011819 beta subunit interaction interface [polypeptide binding]; other site 189918011820 Walker A motif; other site 189918011821 ATP binding site [chemical binding]; other site 189918011822 Walker B motif; other site 189918011823 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 189918011824 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 189918011825 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 189918011826 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 189918011827 ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118 189918011828 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 189918011829 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 189918011830 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 189918011831 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 189918011832 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 189918011833 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 189918011834 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 189918011835 Mg++ binding site [ion binding]; other site 189918011836 putative catalytic motif [active] 189918011837 substrate binding site [chemical binding]; other site 189918011838 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 189918011839 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 189918011840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918011841 S-adenosylmethionine binding site [chemical binding]; other site 189918011842 peptide chain release factor 1; Validated; Region: prfA; PRK00591 189918011843 This domain is found in peptide chain release factors; Region: PCRF; smart00937 189918011844 RF-1 domain; Region: RF-1; pfam00472 189918011845 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 189918011846 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918011847 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918011848 MarR family; Region: MarR_2; pfam12802 189918011849 acyl-CoA synthetase; Provisional; Region: PRK13388 189918011850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918011851 acyl-activating enzyme (AAE) consensus motif; other site 189918011852 AMP binding site [chemical binding]; other site 189918011853 active site 189918011854 CoA binding site [chemical binding]; other site 189918011855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918011856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918011857 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 189918011858 transcription termination factor Rho; Provisional; Region: PRK12608 189918011859 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189918011860 RNA binding site [nucleotide binding]; other site 189918011861 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 189918011862 multimer interface [polypeptide binding]; other site 189918011863 Walker A motif; other site 189918011864 ATP binding site [chemical binding]; other site 189918011865 Walker B motif; other site 189918011866 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 189918011867 threonine synthase; Reviewed; Region: PRK06721 189918011868 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 189918011869 homodimer interface [polypeptide binding]; other site 189918011870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918011871 catalytic residue [active] 189918011872 homoserine dehydrogenase; Provisional; Region: PRK06349 189918011873 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 189918011874 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 189918011875 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 189918011876 diaminopimelate decarboxylase; Region: lysA; TIGR01048 189918011877 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 189918011878 active site 189918011879 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189918011880 substrate binding site [chemical binding]; other site 189918011881 catalytic residues [active] 189918011882 dimer interface [polypeptide binding]; other site 189918011883 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 189918011884 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 189918011885 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 189918011886 active site 189918011887 HIGH motif; other site 189918011888 KMSK motif region; other site 189918011889 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 189918011890 tRNA binding surface [nucleotide binding]; other site 189918011891 anticodon binding site; other site 189918011892 MASE1; Region: MASE1; cl17823 189918011893 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918011894 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 189918011895 putative NAD(P) binding site [chemical binding]; other site 189918011896 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189918011897 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189918011898 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 189918011899 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 189918011900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918011901 putative ADP-binding pocket [chemical binding]; other site 189918011902 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 189918011903 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918011904 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 189918011905 Putative sensor; Region: Sensor; pfam13796 189918011906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189918011907 Histidine kinase; Region: HisKA_3; pfam07730 189918011908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918011909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918011910 active site 189918011911 phosphorylation site [posttranslational modification] 189918011912 intermolecular recognition site; other site 189918011913 dimerization interface [polypeptide binding]; other site 189918011914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918011915 DNA binding residues [nucleotide binding] 189918011916 dimerization interface [polypeptide binding]; other site 189918011917 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 189918011918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918011919 metal binding site [ion binding]; metal-binding site 189918011920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918011921 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918011922 putative substrate translocation pore; other site 189918011923 Uncharacterized conserved protein [Function unknown]; Region: COG2966 189918011924 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 189918011925 Rrf2 family protein; Region: rrf2_super; TIGR00738 189918011926 Transcriptional regulator; Region: Rrf2; pfam02082 189918011927 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 189918011928 Isochorismatase family; Region: Isochorismatase; pfam00857 189918011929 catalytic triad [active] 189918011930 conserved cis-peptide bond; other site 189918011931 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 189918011932 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 189918011933 active site 189918011934 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 189918011935 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 189918011936 CysD dimerization site [polypeptide binding]; other site 189918011937 G1 box; other site 189918011938 putative GEF interaction site [polypeptide binding]; other site 189918011939 GTP/Mg2+ binding site [chemical binding]; other site 189918011940 Switch I region; other site 189918011941 G2 box; other site 189918011942 G3 box; other site 189918011943 Switch II region; other site 189918011944 G4 box; other site 189918011945 G5 box; other site 189918011946 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 189918011947 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 189918011948 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 189918011949 ligand-binding site [chemical binding]; other site 189918011950 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 189918011951 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189918011952 Active Sites [active] 189918011953 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918011954 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918011955 active site 189918011956 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 189918011957 active site clefts [active] 189918011958 zinc binding site [ion binding]; other site 189918011959 dimer interface [polypeptide binding]; other site 189918011960 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 189918011961 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 189918011962 Ligand binding site; other site 189918011963 Ligand binding site; other site 189918011964 Ligand binding site; other site 189918011965 Putative Catalytic site; other site 189918011966 DXD motif; other site 189918011967 Predicted membrane protein [Function unknown]; Region: COG2246 189918011968 GtrA-like protein; Region: GtrA; pfam04138 189918011969 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 189918011970 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 189918011971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918011972 HAMP domain; Region: HAMP; pfam00672 189918011973 dimerization interface [polypeptide binding]; other site 189918011974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918011975 dimer interface [polypeptide binding]; other site 189918011976 phosphorylation site [posttranslational modification] 189918011977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918011978 ATP binding site [chemical binding]; other site 189918011979 Mg2+ binding site [ion binding]; other site 189918011980 G-X-G motif; other site 189918011981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918011982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918011983 active site 189918011984 phosphorylation site [posttranslational modification] 189918011985 intermolecular recognition site; other site 189918011986 dimerization interface [polypeptide binding]; other site 189918011987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918011988 DNA binding site [nucleotide binding] 189918011989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 189918011990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918011991 putative PBP binding loops; other site 189918011992 dimer interface [polypeptide binding]; other site 189918011993 ABC-ATPase subunit interface; other site 189918011994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 189918011995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918011996 dimer interface [polypeptide binding]; other site 189918011997 conserved gate region; other site 189918011998 putative PBP binding loops; other site 189918011999 ABC-ATPase subunit interface; other site 189918012000 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 189918012001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918012002 Walker A/P-loop; other site 189918012003 ATP binding site [chemical binding]; other site 189918012004 Q-loop/lid; other site 189918012005 ABC transporter signature motif; other site 189918012006 Walker B; other site 189918012007 D-loop; other site 189918012008 H-loop/switch region; other site 189918012009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189918012010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189918012011 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 189918012012 Walker A/P-loop; other site 189918012013 ATP binding site [chemical binding]; other site 189918012014 Q-loop/lid; other site 189918012015 ABC transporter signature motif; other site 189918012016 Walker B; other site 189918012017 D-loop; other site 189918012018 H-loop/switch region; other site 189918012019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189918012020 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 189918012021 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 189918012022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918012023 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 189918012024 active site 189918012025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918012026 Walker A/P-loop; other site 189918012027 ATP binding site [chemical binding]; other site 189918012028 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 189918012029 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 189918012030 active site 189918012031 metal binding site [ion binding]; metal-binding site 189918012032 DNA binding site [nucleotide binding] 189918012033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918012034 catalytic core [active] 189918012035 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 189918012036 Winged helix-turn helix; Region: HTH_29; pfam13551 189918012037 Integrase core domain; Region: rve; pfam00665 189918012038 Integrase core domain; Region: rve_3; pfam13683 189918012039 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 189918012040 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 189918012041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189918012042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189918012043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918012044 Walker A/P-loop; other site 189918012045 ATP binding site [chemical binding]; other site 189918012046 Q-loop/lid; other site 189918012047 ABC transporter signature motif; other site 189918012048 Walker B; other site 189918012049 D-loop; other site 189918012050 H-loop/switch region; other site 189918012051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189918012052 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 189918012053 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918012054 Walker A/P-loop; other site 189918012055 ATP binding site [chemical binding]; other site 189918012056 Q-loop/lid; other site 189918012057 ABC transporter signature motif; other site 189918012058 Walker B; other site 189918012059 D-loop; other site 189918012060 H-loop/switch region; other site 189918012061 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 189918012062 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918012063 molybdopterin cofactor binding site; other site 189918012064 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 189918012065 molybdopterin cofactor binding site; other site 189918012066 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 189918012067 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 189918012068 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918012069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918012070 acyl-activating enzyme (AAE) consensus motif; other site 189918012071 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918012072 AMP binding site [chemical binding]; other site 189918012073 active site 189918012074 acyl-activating enzyme (AAE) consensus motif; other site 189918012075 CoA binding site [chemical binding]; other site 189918012076 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918012077 metal-binding site [ion binding] 189918012078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189918012079 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189918012080 metal-binding site [ion binding] 189918012081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918012082 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918012083 cyclase homology domain; Region: CHD; cd07302 189918012084 nucleotidyl binding site; other site 189918012085 metal binding site [ion binding]; metal-binding site 189918012086 dimer interface [polypeptide binding]; other site 189918012087 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 189918012088 putative active site [active] 189918012089 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918012090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918012091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 189918012092 putative dimer interface [polypeptide binding]; other site 189918012093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918012094 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 189918012095 HIT family signature motif; other site 189918012096 catalytic residue [active] 189918012097 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918012098 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 189918012099 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918012100 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 189918012101 Fe-S cluster binding site [ion binding]; other site 189918012102 DNA binding site [nucleotide binding] 189918012103 active site 189918012104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012105 H+ Antiporter protein; Region: 2A0121; TIGR00900 189918012106 putative substrate translocation pore; other site 189918012107 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918012108 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 189918012109 SCP-2 sterol transfer family; Region: SCP2; cl01225 189918012110 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 189918012111 FAD binding domain; Region: FAD_binding_4; pfam01565 189918012112 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 189918012113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918012114 Cytochrome P450; Region: p450; cl12078 189918012115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012117 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189918012118 Sulfatase; Region: Sulfatase; pfam00884 189918012119 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 189918012120 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 189918012121 FAD binding pocket [chemical binding]; other site 189918012122 FAD binding motif [chemical binding]; other site 189918012123 phosphate binding motif [ion binding]; other site 189918012124 NAD binding pocket [chemical binding]; other site 189918012125 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918012126 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 189918012127 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 189918012128 ATP binding site [chemical binding]; other site 189918012129 Mg++ binding site [ion binding]; other site 189918012130 motif III; other site 189918012131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918012132 nucleotide binding region [chemical binding]; other site 189918012133 ATP-binding site [chemical binding]; other site 189918012134 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 189918012135 putative RNA binding site [nucleotide binding]; other site 189918012136 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 189918012137 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 189918012138 RNase_H superfamily; Region: RNase_H_2; pfam13482 189918012139 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 189918012140 Part of AAA domain; Region: AAA_19; pfam13245 189918012141 AAA domain; Region: AAA_12; pfam13087 189918012142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918012144 putative substrate translocation pore; other site 189918012145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012147 putative substrate translocation pore; other site 189918012148 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 189918012149 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189918012150 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 189918012151 TPP-binding site [chemical binding]; other site 189918012152 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 189918012153 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918012154 short chain dehydrogenase; Provisional; Region: PRK07832 189918012155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012156 NAD(P) binding site [chemical binding]; other site 189918012157 active site 189918012158 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 189918012159 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 189918012160 Malic enzyme, N-terminal domain; Region: malic; pfam00390 189918012161 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 189918012162 putative NAD(P) binding site [chemical binding]; other site 189918012163 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 189918012164 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 189918012165 oligomer interface [polypeptide binding]; other site 189918012166 metal binding site [ion binding]; metal-binding site 189918012167 metal binding site [ion binding]; metal-binding site 189918012168 putative Cl binding site [ion binding]; other site 189918012169 basic sphincter; other site 189918012170 hydrophobic gate; other site 189918012171 periplasmic entrance; other site 189918012172 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 189918012173 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 189918012174 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 189918012175 Walker A/P-loop; other site 189918012176 ATP binding site [chemical binding]; other site 189918012177 Q-loop/lid; other site 189918012178 ABC transporter signature motif; other site 189918012179 Walker B; other site 189918012180 D-loop; other site 189918012181 H-loop/switch region; other site 189918012182 TOBE domain; Region: TOBE_2; pfam08402 189918012183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 189918012184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918012185 dimer interface [polypeptide binding]; other site 189918012186 conserved gate region; other site 189918012187 putative PBP binding loops; other site 189918012188 ABC-ATPase subunit interface; other site 189918012189 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189918012190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918012191 dimer interface [polypeptide binding]; other site 189918012192 conserved gate region; other site 189918012193 putative PBP binding loops; other site 189918012194 ABC-ATPase subunit interface; other site 189918012195 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 189918012196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 189918012197 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 189918012198 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 189918012199 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 189918012200 MgtE intracellular N domain; Region: MgtE_N; smart00924 189918012201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 189918012202 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 189918012203 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 189918012204 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189918012205 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189918012206 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 189918012207 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 189918012208 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 189918012209 sec-independent translocase; Provisional; Region: PRK03100 189918012210 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189918012211 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189918012212 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189918012213 protein binding site [polypeptide binding]; other site 189918012214 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 189918012215 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 189918012216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918012217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918012218 DNA binding residues [nucleotide binding] 189918012219 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 189918012220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918012221 S-adenosylmethionine binding site [chemical binding]; other site 189918012222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012224 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189918012225 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 189918012226 Walker A/P-loop; other site 189918012227 ATP binding site [chemical binding]; other site 189918012228 Q-loop/lid; other site 189918012229 ABC transporter signature motif; other site 189918012230 Walker B; other site 189918012231 D-loop; other site 189918012232 H-loop/switch region; other site 189918012233 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 189918012234 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189918012235 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 189918012236 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 189918012237 ligand binding site; other site 189918012238 oligomer interface; other site 189918012239 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 189918012240 dimer interface [polypeptide binding]; other site 189918012241 N-terminal domain interface [polypeptide binding]; other site 189918012242 sulfate 1 binding site; other site 189918012243 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 189918012244 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918012245 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 189918012246 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 189918012247 DivIVA domain; Region: DivI1A_domain; TIGR03544 189918012248 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 189918012249 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189918012250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 189918012251 dihydropteroate synthase; Region: DHPS; TIGR01496 189918012252 substrate binding pocket [chemical binding]; other site 189918012253 dimer interface [polypeptide binding]; other site 189918012254 inhibitor binding site; inhibition site 189918012255 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 189918012256 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 189918012257 acyl-activating enzyme (AAE) consensus motif; other site 189918012258 putative AMP binding site [chemical binding]; other site 189918012259 putative active site [active] 189918012260 putative CoA binding site [chemical binding]; other site 189918012261 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 189918012262 AAA domain; Region: AAA_22; pfam13401 189918012263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918012264 Walker A motif; other site 189918012265 ATP binding site [chemical binding]; other site 189918012266 Walker B motif; other site 189918012267 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 189918012268 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189918012269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918012270 Walker A/P-loop; other site 189918012271 ATP binding site [chemical binding]; other site 189918012272 Q-loop/lid; other site 189918012273 ABC transporter signature motif; other site 189918012274 Walker B; other site 189918012275 D-loop; other site 189918012276 H-loop/switch region; other site 189918012277 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918012278 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 189918012279 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 189918012280 metal binding site [ion binding]; metal-binding site 189918012281 putative dimer interface [polypeptide binding]; other site 189918012282 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 189918012283 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 189918012284 putative trimer interface [polypeptide binding]; other site 189918012285 putative CoA binding site [chemical binding]; other site 189918012286 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918012287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918012288 active site residue [active] 189918012289 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918012290 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189918012291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189918012292 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189918012293 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918012294 putative homodimer interface [polypeptide binding]; other site 189918012295 putative homotetramer interface [polypeptide binding]; other site 189918012296 putative allosteric switch controlling residues; other site 189918012297 putative metal binding site [ion binding]; other site 189918012298 putative homodimer-homodimer interface [polypeptide binding]; other site 189918012299 Domain of unknown function DUF302; Region: DUF302; cl01364 189918012300 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 189918012301 acyl-CoA synthetase; Validated; Region: PRK07787 189918012302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918012303 acyl-activating enzyme (AAE) consensus motif; other site 189918012304 AMP binding site [chemical binding]; other site 189918012305 active site 189918012306 CoA binding site [chemical binding]; other site 189918012307 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 189918012308 dimer interface [polypeptide binding]; other site 189918012309 ADP-ribose binding site [chemical binding]; other site 189918012310 active site 189918012311 nudix motif; other site 189918012312 metal binding site [ion binding]; metal-binding site 189918012313 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918012314 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 189918012315 SnoaL-like domain; Region: SnoaL_3; pfam13474 189918012316 Proline dehydrogenase; Region: Pro_dh; cl03282 189918012317 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 189918012318 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 189918012319 Glutamate binding site [chemical binding]; other site 189918012320 NAD binding site [chemical binding]; other site 189918012321 catalytic residues [active] 189918012322 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 189918012323 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918012324 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918012325 active site 189918012326 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918012327 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 189918012328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918012329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012330 homodimer interface [polypeptide binding]; other site 189918012331 catalytic residue [active] 189918012332 Ferredoxin [Energy production and conversion]; Region: COG1146 189918012333 4Fe-4S binding domain; Region: Fer4; pfam00037 189918012334 Uncharacterized conserved protein [Function unknown]; Region: COG2353 189918012335 FO synthase; Reviewed; Region: fbiC; PRK09234 189918012336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918012337 FeS/SAM binding site; other site 189918012338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918012339 FeS/SAM binding site; other site 189918012340 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 189918012341 Homeodomain-like domain; Region: HTH_23; pfam13384 189918012342 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918012343 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918012344 Integrase core domain; Region: rve; pfam00665 189918012345 putative minor structural protein; Region: PHA01351 189918012346 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 189918012347 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 189918012348 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 189918012349 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 189918012350 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 189918012351 G1 box; other site 189918012352 putative GEF interaction site [polypeptide binding]; other site 189918012353 GTP/Mg2+ binding site [chemical binding]; other site 189918012354 Switch I region; other site 189918012355 G2 box; other site 189918012356 G3 box; other site 189918012357 Switch II region; other site 189918012358 G4 box; other site 189918012359 G5 box; other site 189918012360 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 189918012361 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 189918012362 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 189918012363 active site 189918012364 8-oxo-dGMP binding site [chemical binding]; other site 189918012365 nudix motif; other site 189918012366 metal binding site [ion binding]; metal-binding site 189918012367 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 189918012368 aromatic arch; other site 189918012369 DCoH dimer interaction site [polypeptide binding]; other site 189918012370 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 189918012371 DCoH tetramer interaction site [polypeptide binding]; other site 189918012372 substrate binding site [chemical binding]; other site 189918012373 mannosyltransferase; Provisional; Region: pimE; PRK13375 189918012374 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 189918012375 uncharacterized HhH-GPD family protein; Region: TIGR03252 189918012376 minor groove reading motif; other site 189918012377 helix-hairpin-helix signature motif; other site 189918012378 Histidine kinase; Region: His_kinase; pfam06580 189918012379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918012380 ATP binding site [chemical binding]; other site 189918012381 Mg2+ binding site [ion binding]; other site 189918012382 G-X-G motif; other site 189918012383 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 189918012384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918012385 active site 189918012386 phosphorylation site [posttranslational modification] 189918012387 intermolecular recognition site; other site 189918012388 dimerization interface [polypeptide binding]; other site 189918012389 LytTr DNA-binding domain; Region: LytTR; smart00850 189918012390 Protein of unknown function, DUF485; Region: DUF485; pfam04341 189918012391 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 189918012392 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 189918012393 Protein of unknown function, DUF485; Region: DUF485; pfam04341 189918012394 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 189918012395 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 189918012396 Na binding site [ion binding]; other site 189918012397 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918012398 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 189918012399 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918012400 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 189918012401 Predicted transcriptional regulators [Transcription]; Region: COG1725 189918012402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918012403 DNA-binding site [nucleotide binding]; DNA binding site 189918012404 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 189918012405 NAD-dependent deacetylase; Provisional; Region: PRK00481 189918012406 NAD+ binding site [chemical binding]; other site 189918012407 substrate binding site [chemical binding]; other site 189918012408 Zn binding site [ion binding]; other site 189918012409 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189918012410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918012411 S-adenosylmethionine binding site [chemical binding]; other site 189918012412 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918012413 DoxX; Region: DoxX; pfam07681 189918012414 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 189918012415 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918012416 FMN binding site [chemical binding]; other site 189918012417 substrate binding site [chemical binding]; other site 189918012418 putative catalytic residue [active] 189918012419 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 189918012420 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 189918012421 NAD binding site [chemical binding]; other site 189918012422 homodimer interface [polypeptide binding]; other site 189918012423 homotetramer interface [polypeptide binding]; other site 189918012424 active site 189918012425 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918012426 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918012427 enoyl-CoA hydratase; Provisional; Region: PRK06688 189918012428 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918012429 substrate binding site [chemical binding]; other site 189918012430 oxyanion hole (OAH) forming residues; other site 189918012431 trimer interface [polypeptide binding]; other site 189918012432 HicB family; Region: HicB; pfam05534 189918012433 H+ Antiporter protein; Region: 2A0121; TIGR00900 189918012434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012435 CAAX protease self-immunity; Region: Abi; pfam02517 189918012436 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 189918012437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012438 NAD(P) binding site [chemical binding]; other site 189918012439 active site 189918012440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918012443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918012444 active site 189918012445 catalytic tetrad [active] 189918012446 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 189918012447 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 189918012448 trimer interface [polypeptide binding]; other site 189918012449 putative metal binding site [ion binding]; other site 189918012450 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 189918012451 Fasciclin domain; Region: Fasciclin; pfam02469 189918012452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918012453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918012454 active site 189918012455 enoyl-CoA hydratase; Provisional; Region: PRK08252 189918012456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918012457 substrate binding site [chemical binding]; other site 189918012458 oxyanion hole (OAH) forming residues; other site 189918012459 trimer interface [polypeptide binding]; other site 189918012460 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 189918012461 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918012462 dimer interface [polypeptide binding]; other site 189918012463 active site 189918012464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918012465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918012466 FCD domain; Region: FCD; pfam07729 189918012467 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 189918012468 Predicted membrane protein [Function unknown]; Region: COG2259 189918012469 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918012470 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918012471 classical (c) SDRs; Region: SDR_c; cd05233 189918012472 NAD(P) binding site [chemical binding]; other site 189918012473 active site 189918012474 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918012475 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 189918012476 dimer interface [polypeptide binding]; other site 189918012477 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918012478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918012479 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189918012480 hypothetical protein; Provisional; Region: PRK06149 189918012481 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 189918012482 active site 189918012483 ATP binding site [chemical binding]; other site 189918012484 substrate binding site [chemical binding]; other site 189918012485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918012486 inhibitor-cofactor binding pocket; inhibition site 189918012487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012488 catalytic residue [active] 189918012489 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918012490 cyclase homology domain; Region: CHD; cd07302 189918012491 nucleotidyl binding site; other site 189918012492 metal binding site [ion binding]; metal-binding site 189918012493 dimer interface [polypeptide binding]; other site 189918012494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918012495 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918012496 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918012497 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 189918012498 putative hydrophobic ligand binding site [chemical binding]; other site 189918012499 Domain of unknown function (DU1801); Region: DUF1801; cl17490 189918012500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918012501 dimerization interface [polypeptide binding]; other site 189918012502 putative DNA binding site [nucleotide binding]; other site 189918012503 putative Zn2+ binding site [ion binding]; other site 189918012504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918012505 active site residue [active] 189918012506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918012508 putative substrate translocation pore; other site 189918012509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189918012510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918012511 S-adenosylmethionine binding site [chemical binding]; other site 189918012512 GTP-binding protein YchF; Reviewed; Region: PRK09601 189918012513 YchF GTPase; Region: YchF; cd01900 189918012514 G1 box; other site 189918012515 GTP/Mg2+ binding site [chemical binding]; other site 189918012516 Switch I region; other site 189918012517 G2 box; other site 189918012518 Switch II region; other site 189918012519 G3 box; other site 189918012520 G4 box; other site 189918012521 G5 box; other site 189918012522 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 189918012523 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 189918012524 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 189918012525 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 189918012526 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 189918012527 generic binding surface II; other site 189918012528 generic binding surface I; other site 189918012529 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 189918012530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012531 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 189918012532 NAD(P) binding site [chemical binding]; other site 189918012533 active site 189918012534 MgtC family; Region: MgtC; pfam02308 189918012535 magnesium transport protein MgtC; Provisional; Region: PRK15385 189918012536 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189918012537 Sulfatase; Region: Sulfatase; pfam00884 189918012538 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189918012539 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 189918012540 Uncharacterized conserved protein [Function unknown]; Region: COG1262 189918012541 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 189918012542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918012543 classical (c) SDRs; Region: SDR_c; cd05233 189918012544 NAD(P) binding site [chemical binding]; other site 189918012545 active site 189918012546 classical (c) SDRs; Region: SDR_c; cd05233 189918012547 short chain dehydrogenase; Provisional; Region: PRK05650 189918012548 NAD(P) binding site [chemical binding]; other site 189918012549 active site 189918012550 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 189918012551 Domain of unknown function DUF20; Region: UPF0118; pfam01594 189918012552 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189918012553 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 189918012554 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 189918012555 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 189918012556 putative active site [active] 189918012557 fumarate hydratase; Reviewed; Region: fumC; PRK00485 189918012558 Class II fumarases; Region: Fumarase_classII; cd01362 189918012559 active site 189918012560 tetramer interface [polypeptide binding]; other site 189918012561 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918012562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012563 NAD(P) binding site [chemical binding]; other site 189918012564 active site 189918012565 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918012566 dimer interface [polypeptide binding]; other site 189918012567 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918012568 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189918012569 GAF domain; Region: GAF_3; pfam13492 189918012570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918012571 Histidine kinase; Region: HisKA_3; pfam07730 189918012572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918012573 ATP binding site [chemical binding]; other site 189918012574 Mg2+ binding site [ion binding]; other site 189918012575 G-X-G motif; other site 189918012576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918012577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918012578 active site 189918012579 phosphorylation site [posttranslational modification] 189918012580 intermolecular recognition site; other site 189918012581 dimerization interface [polypeptide binding]; other site 189918012582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918012583 DNA binding residues [nucleotide binding] 189918012584 dimerization interface [polypeptide binding]; other site 189918012585 Universal stress protein family; Region: Usp; pfam00582 189918012586 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 189918012587 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 189918012588 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 189918012589 putative active site [active] 189918012590 PhoH-like protein; Region: PhoH; pfam02562 189918012591 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 189918012592 dinuclear metal binding motif [ion binding]; other site 189918012593 serine hydroxymethyltransferase; Provisional; Region: PRK13580 189918012594 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 189918012595 dimer interface [polypeptide binding]; other site 189918012596 active site 189918012597 glycine-pyridoxal phosphate binding site [chemical binding]; other site 189918012598 folate binding site [chemical binding]; other site 189918012599 pantothenate kinase; Provisional; Region: PRK05439 189918012600 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 189918012601 ATP-binding site [chemical binding]; other site 189918012602 CoA-binding site [chemical binding]; other site 189918012603 Mg2+-binding site [ion binding]; other site 189918012604 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 189918012605 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 189918012606 catalytic residue [active] 189918012607 putative FPP diphosphate binding site; other site 189918012608 putative FPP binding hydrophobic cleft; other site 189918012609 dimer interface [polypeptide binding]; other site 189918012610 putative IPP diphosphate binding site; other site 189918012611 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 189918012612 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 189918012613 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918012614 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 189918012615 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 189918012616 catalytic residues [active] 189918012617 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 189918012618 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 189918012619 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 189918012620 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 189918012621 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 189918012622 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 189918012623 cystathionine gamma-synthase; Provisional; Region: PRK07811 189918012624 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 189918012625 homodimer interface [polypeptide binding]; other site 189918012626 substrate-cofactor binding pocket; other site 189918012627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012628 catalytic residue [active] 189918012629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918012630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918012631 active site 189918012632 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 189918012633 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 189918012634 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189918012635 dimer interface [polypeptide binding]; other site 189918012636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012637 catalytic residue [active] 189918012638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 189918012639 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 189918012640 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 189918012641 active site 189918012642 catalytic triad [active] 189918012643 oxyanion hole [active] 189918012644 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 189918012645 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918012646 dimer interface [polypeptide binding]; other site 189918012647 active site 189918012648 Bax inhibitor 1 like; Region: BaxI_1; cl17691 189918012649 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 189918012650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918012651 substrate binding site [chemical binding]; other site 189918012652 oxyanion hole (OAH) forming residues; other site 189918012653 trimer interface [polypeptide binding]; other site 189918012654 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 189918012655 enoyl-CoA hydratase; Provisional; Region: PRK05862 189918012656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918012657 substrate binding site [chemical binding]; other site 189918012658 oxyanion hole (OAH) forming residues; other site 189918012659 trimer interface [polypeptide binding]; other site 189918012660 Predicted membrane protein [Function unknown]; Region: COG4425 189918012661 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 189918012662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189918012663 active site residue [active] 189918012664 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 189918012665 hypothetical protein; Provisional; Region: PRK10279 189918012666 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 189918012667 active site 189918012668 nucleophile elbow; other site 189918012669 Patatin-like phospholipase; Region: Patatin; pfam01734 189918012670 nucleophile elbow; other site 189918012671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 189918012672 MOSC domain; Region: MOSC; pfam03473 189918012673 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918012674 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918012675 lipid-transfer protein; Provisional; Region: PRK08256 189918012676 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918012677 active site 189918012678 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 189918012679 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 189918012680 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 189918012681 PAS domain; Region: PAS; smart00091 189918012682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918012683 ATP binding site [chemical binding]; other site 189918012684 Mg2+ binding site [ion binding]; other site 189918012685 G-X-G motif; other site 189918012686 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 189918012687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918012688 active site 189918012689 phosphorylation site [posttranslational modification] 189918012690 intermolecular recognition site; other site 189918012691 dimerization interface [polypeptide binding]; other site 189918012692 Homeodomain-like domain; Region: HTH_23; pfam13384 189918012693 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189918012694 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 189918012695 amidase catalytic site [active] 189918012696 Zn binding residues [ion binding]; other site 189918012697 substrate binding site [chemical binding]; other site 189918012698 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 189918012699 Cupin domain; Region: Cupin_2; pfam07883 189918012700 Putative esterase; Region: Esterase; pfam00756 189918012701 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 189918012702 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 189918012703 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 189918012704 Cation efflux family; Region: Cation_efflux; cl00316 189918012705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918012706 dimerization interface [polypeptide binding]; other site 189918012707 putative DNA binding site [nucleotide binding]; other site 189918012708 putative Zn2+ binding site [ion binding]; other site 189918012709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189918012710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189918012711 Coenzyme A binding pocket [chemical binding]; other site 189918012712 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 189918012713 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189918012714 inhibitor-cofactor binding pocket; inhibition site 189918012715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012716 catalytic residue [active] 189918012717 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 189918012718 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 189918012719 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 189918012720 E-class dimer interface [polypeptide binding]; other site 189918012721 P-class dimer interface [polypeptide binding]; other site 189918012722 active site 189918012723 Cu2+ binding site [ion binding]; other site 189918012724 Zn2+ binding site [ion binding]; other site 189918012725 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 189918012726 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189918012727 dimer interface [polypeptide binding]; other site 189918012728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918012729 catalytic residue [active] 189918012730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 189918012731 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918012732 active site residue [active] 189918012733 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 189918012734 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 189918012735 Cl- selectivity filter; other site 189918012736 Cl- binding residues [ion binding]; other site 189918012737 pore gating glutamate residue; other site 189918012738 dimer interface [polypeptide binding]; other site 189918012739 H+/Cl- coupling transport residue; other site 189918012740 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918012741 Cytochrome P450; Region: p450; cl12078 189918012742 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918012743 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918012744 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 189918012745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918012746 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918012747 hypothetical protein; Provisional; Region: PRK08317 189918012748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918012749 S-adenosylmethionine binding site [chemical binding]; other site 189918012750 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918012751 aldose dehydrogenase; Validated; Region: PRK06398 189918012752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918012754 active site 189918012755 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 189918012756 active site 189918012757 diiron metal binding site [ion binding]; other site 189918012758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012760 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 189918012761 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 189918012762 substrate binding pocket [chemical binding]; other site 189918012763 catalytic triad [active] 189918012764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918012765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918012766 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189918012767 salt bridge; other site 189918012768 non-specific DNA binding site [nucleotide binding]; other site 189918012769 sequence-specific DNA binding site [nucleotide binding]; other site 189918012770 Domain of unknown function (DUF385); Region: DUF385; cl04387 189918012771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918012772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012773 putative substrate translocation pore; other site 189918012774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918012777 D-galactonate transporter; Region: 2A0114; TIGR00893 189918012778 putative substrate translocation pore; other site 189918012779 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 189918012780 homotrimer interaction site [polypeptide binding]; other site 189918012781 putative active site [active] 189918012782 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 189918012783 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 189918012784 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 189918012785 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918012786 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918012787 K+-transporting ATPase, c chain; Region: KdpC; cl00944 189918012788 K+-transporting ATPase, c chain; Region: KdpC; cl00944 189918012789 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 189918012790 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 189918012791 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 189918012792 Ligand Binding Site [chemical binding]; other site 189918012793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918012794 dimer interface [polypeptide binding]; other site 189918012795 phosphorylation site [posttranslational modification] 189918012796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918012797 ATP binding site [chemical binding]; other site 189918012798 Mg2+ binding site [ion binding]; other site 189918012799 G-X-G motif; other site 189918012800 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 189918012801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918012802 active site 189918012803 phosphorylation site [posttranslational modification] 189918012804 intermolecular recognition site; other site 189918012805 dimerization interface [polypeptide binding]; other site 189918012806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918012807 DNA binding site [nucleotide binding] 189918012808 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 189918012809 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918012810 acyl-activating enzyme (AAE) consensus motif; other site 189918012811 AMP binding site [chemical binding]; other site 189918012812 active site 189918012813 CoA binding site [chemical binding]; other site 189918012814 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 189918012815 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 189918012816 catalytic residues [active] 189918012817 catalytic nucleophile [active] 189918012818 Recombinase; Region: Recombinase; pfam07508 189918012819 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 189918012820 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 189918012821 GIY-YIG motif/motif A; other site 189918012822 active site 189918012823 catalytic site [active] 189918012824 metal binding site [ion binding]; metal-binding site 189918012825 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 189918012826 Phage capsid family; Region: Phage_capsid; pfam05065 189918012827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 189918012828 Trp repressor protein; Region: Trp_repressor; cl17266 189918012829 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 189918012830 active site 189918012831 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 189918012832 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 189918012833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918012834 Radical SAM superfamily; Region: Radical_SAM; pfam04055 189918012835 FeS/SAM binding site; other site 189918012836 exopolyphosphatase; Region: exo_poly_only; TIGR03706 189918012837 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 189918012838 Uncharacterized conserved protein [Function unknown]; Region: COG1507 189918012839 Septum formation initiator; Region: DivIC; pfam04977 189918012840 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 189918012841 enolase; Provisional; Region: eno; PRK00077 189918012842 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 189918012843 dimer interface [polypeptide binding]; other site 189918012844 metal binding site [ion binding]; metal-binding site 189918012845 substrate binding pocket [chemical binding]; other site 189918012846 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 189918012847 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189918012848 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189918012849 Imelysin; Region: Peptidase_M75; pfam09375 189918012850 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 189918012851 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 189918012852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 189918012853 homodimer interface [polypeptide binding]; other site 189918012854 metal binding site [ion binding]; metal-binding site 189918012855 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 189918012856 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 189918012857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918012858 ATP binding site [chemical binding]; other site 189918012859 putative Mg++ binding site [ion binding]; other site 189918012860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918012861 nucleotide binding region [chemical binding]; other site 189918012862 ATP-binding site [chemical binding]; other site 189918012863 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 189918012864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918012865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918012866 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 189918012867 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 189918012868 Substrate binding site; other site 189918012869 Mg++ binding site; other site 189918012870 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 189918012871 active site 189918012872 substrate binding site [chemical binding]; other site 189918012873 CoA binding site [chemical binding]; other site 189918012874 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 189918012875 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 189918012876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918012877 active site 189918012878 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 189918012879 ArsC family; Region: ArsC; pfam03960 189918012880 catalytic residues [active] 189918012881 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 189918012882 short chain dehydrogenase; Provisional; Region: PRK06197 189918012883 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 189918012884 putative NAD(P) binding site [chemical binding]; other site 189918012885 active site 189918012886 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 189918012887 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 189918012888 5S rRNA interface [nucleotide binding]; other site 189918012889 CTC domain interface [polypeptide binding]; other site 189918012890 L16 interface [polypeptide binding]; other site 189918012891 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 189918012892 putative active site [active] 189918012893 catalytic residue [active] 189918012894 Protein of unknown function, DUF488; Region: DUF488; pfam04343 189918012895 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 189918012896 4Fe-4S binding domain; Region: Fer4; pfam00037 189918012897 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 189918012898 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918012899 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918012900 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918012901 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918012902 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 189918012903 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189918012904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918012905 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 189918012906 Walker A/P-loop; other site 189918012907 ATP binding site [chemical binding]; other site 189918012908 Q-loop/lid; other site 189918012909 ABC transporter signature motif; other site 189918012910 Walker B; other site 189918012911 D-loop; other site 189918012912 H-loop/switch region; other site 189918012913 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 189918012914 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918012915 acyl-activating enzyme (AAE) consensus motif; other site 189918012916 active site 189918012917 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 189918012918 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 189918012919 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 189918012920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918012921 S-adenosylmethionine binding site [chemical binding]; other site 189918012922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 189918012923 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918012924 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918012925 Domain of unknown function (DUF348); Region: DUF348; pfam03990 189918012926 G5 domain; Region: G5; pfam07501 189918012927 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918012928 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 189918012929 active site 189918012930 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 189918012931 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 189918012932 active site 189918012933 HIGH motif; other site 189918012934 KMSKS motif; other site 189918012935 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 189918012936 tRNA binding surface [nucleotide binding]; other site 189918012937 anticodon binding site; other site 189918012938 glutamate dehydrogenase; Provisional; Region: PRK09414 189918012939 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 189918012940 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 189918012941 NAD(P) binding site [chemical binding]; other site 189918012942 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189918012943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918012944 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 189918012945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918012946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918012947 DNA binding residues [nucleotide binding] 189918012948 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918012949 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189918012950 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 189918012951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918012952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918012953 DNA binding residues [nucleotide binding] 189918012954 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918012955 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 189918012956 chorismate binding enzyme; Region: Chorismate_bind; cl10555 189918012957 Predicted methyltransferases [General function prediction only]; Region: COG0313 189918012958 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 189918012959 putative SAM binding site [chemical binding]; other site 189918012960 putative homodimer interface [polypeptide binding]; other site 189918012961 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 189918012962 arginine deiminase; Provisional; Region: PRK01388 189918012963 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 189918012964 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 189918012965 DNA binding residues [nucleotide binding] 189918012966 dimer interface [polypeptide binding]; other site 189918012967 [2Fe-2S] cluster binding site [ion binding]; other site 189918012968 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 189918012969 PE-PPE domain; Region: PE-PPE; pfam08237 189918012970 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 189918012971 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 189918012972 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 189918012973 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 189918012974 shikimate binding site; other site 189918012975 NAD(P) binding site [chemical binding]; other site 189918012976 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189918012977 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189918012978 ligand binding site [chemical binding]; other site 189918012979 flexible hinge region; other site 189918012980 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 189918012981 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189918012982 Uncharacterized conserved protein [Function unknown]; Region: COG5361 189918012983 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 189918012984 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 189918012985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189918012986 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 189918012987 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 189918012988 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 189918012989 dimer interface [polypeptide binding]; other site 189918012990 putative functional site; other site 189918012991 putative MPT binding site; other site 189918012992 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 189918012993 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 189918012994 active site 189918012995 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 189918012996 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 189918012997 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 189918012998 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 189918012999 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 189918013000 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 189918013001 Homeodomain-like domain; Region: HTH_23; pfam13384 189918013002 Helix-turn-helix domain; Region: HTH_38; pfam13936 189918013003 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 189918013004 Integrase core domain; Region: rve; pfam00665 189918013005 MspA; Region: MspA; pfam09203 189918013006 MspA; Region: MspA; pfam09203 189918013007 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 189918013008 MPT binding site; other site 189918013009 trimer interface [polypeptide binding]; other site 189918013010 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189918013011 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189918013012 protein binding site [polypeptide binding]; other site 189918013013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918013014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918013015 dimerization interface [polypeptide binding]; other site 189918013016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918013017 dimer interface [polypeptide binding]; other site 189918013018 phosphorylation site [posttranslational modification] 189918013019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918013020 ATP binding site [chemical binding]; other site 189918013021 Mg2+ binding site [ion binding]; other site 189918013022 G-X-G motif; other site 189918013023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918013024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918013025 active site 189918013026 phosphorylation site [posttranslational modification] 189918013027 intermolecular recognition site; other site 189918013028 dimerization interface [polypeptide binding]; other site 189918013029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918013030 DNA binding site [nucleotide binding] 189918013031 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 189918013032 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 189918013033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918013035 active site 189918013036 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918013037 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918013038 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918013039 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 189918013040 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189918013041 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189918013042 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 189918013043 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189918013044 carboxyltransferase (CT) interaction site; other site 189918013045 biotinylation site [posttranslational modification]; other site 189918013046 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013047 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918013048 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918013049 active site 189918013050 enoyl-CoA hydratase; Provisional; Region: PRK07827 189918013051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013052 substrate binding site [chemical binding]; other site 189918013053 oxyanion hole (OAH) forming residues; other site 189918013054 trimer interface [polypeptide binding]; other site 189918013055 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 189918013056 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 189918013057 PE-PPE domain; Region: PE-PPE; pfam08237 189918013058 PE-PPE domain; Region: PE-PPE; pfam08237 189918013059 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 189918013060 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 189918013061 metal ion-dependent adhesion site (MIDAS); other site 189918013062 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 189918013063 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 189918013064 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 189918013065 Sulfate transporter family; Region: Sulfate_transp; pfam00916 189918013066 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 189918013067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918013068 dimerization interface [polypeptide binding]; other site 189918013069 putative DNA binding site [nucleotide binding]; other site 189918013070 putative Zn2+ binding site [ion binding]; other site 189918013071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918013072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918013073 active site 189918013074 ATP binding site [chemical binding]; other site 189918013075 substrate binding site [chemical binding]; other site 189918013076 activation loop (A-loop); other site 189918013077 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 189918013078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918013079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918013080 metal binding site [ion binding]; metal-binding site 189918013081 active site 189918013082 I-site; other site 189918013083 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 189918013084 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 189918013085 purine monophosphate binding site [chemical binding]; other site 189918013086 dimer interface [polypeptide binding]; other site 189918013087 putative catalytic residues [active] 189918013088 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 189918013089 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 189918013090 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 189918013091 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 189918013092 active site 189918013093 cosubstrate binding site; other site 189918013094 substrate binding site [chemical binding]; other site 189918013095 catalytic site [active] 189918013096 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 189918013097 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 189918013098 active site 189918013099 dimer interface [polypeptide binding]; other site 189918013100 non-prolyl cis peptide bond; other site 189918013101 insertion regions; other site 189918013102 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918013103 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918013104 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 189918013105 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 189918013106 active site 189918013107 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 189918013108 CoA binding domain; Region: CoA_binding; smart00881 189918013109 CoA-ligase; Region: Ligase_CoA; pfam00549 189918013110 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 189918013111 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 189918013112 CoA-ligase; Region: Ligase_CoA; pfam00549 189918013113 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189918013114 Peptidase family M23; Region: Peptidase_M23; pfam01551 189918013115 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 189918013116 Part of AAA domain; Region: AAA_19; pfam13245 189918013117 Family description; Region: UvrD_C_2; pfam13538 189918013118 hypothetical protein; Provisional; Region: PRK07857 189918013119 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918013120 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189918013121 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189918013122 active site 189918013123 catalytic triad [active] 189918013124 oxyanion hole [active] 189918013125 succinic semialdehyde dehydrogenase; Region: PLN02278 189918013126 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 189918013127 tetramerization interface [polypeptide binding]; other site 189918013128 NAD(P) binding site [chemical binding]; other site 189918013129 catalytic residues [active] 189918013130 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 189918013131 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 189918013132 active site 189918013133 dimer interface [polypeptide binding]; other site 189918013134 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 189918013135 dimer interface [polypeptide binding]; other site 189918013136 active site 189918013137 short chain dehydrogenase; Provisional; Region: PRK08251 189918013138 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 189918013139 putative NAD(P) binding site [chemical binding]; other site 189918013140 active site 189918013141 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 189918013142 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 189918013143 putative DNA binding site [nucleotide binding]; other site 189918013144 catalytic residue [active] 189918013145 putative H2TH interface [polypeptide binding]; other site 189918013146 putative catalytic residues [active] 189918013147 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 189918013148 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 189918013149 Predicted membrane protein [Function unknown]; Region: COG1950 189918013150 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 189918013151 active site 189918013152 SAM binding site [chemical binding]; other site 189918013153 homodimer interface [polypeptide binding]; other site 189918013154 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 189918013155 thiamine pyrophosphate protein; Provisional; Region: PRK08273 189918013156 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 189918013157 PYR/PP interface [polypeptide binding]; other site 189918013158 dimer interface [polypeptide binding]; other site 189918013159 tetramer interface [polypeptide binding]; other site 189918013160 TPP binding site [chemical binding]; other site 189918013161 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 189918013162 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 189918013163 TPP-binding site [chemical binding]; other site 189918013164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918013165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918013166 putative substrate translocation pore; other site 189918013167 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 189918013168 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918013169 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918013170 Helix-turn-helix domain; Region: HTH_18; pfam12833 189918013171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918013172 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 189918013173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013174 NAD(P) binding site [chemical binding]; other site 189918013175 active site 189918013176 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 189918013177 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189918013178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189918013179 phosphopeptide binding site; other site 189918013180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918013181 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 189918013182 DNA binding residues [nucleotide binding] 189918013183 dimerization interface [polypeptide binding]; other site 189918013184 Protein kinase domain; Region: Pkinase; pfam00069 189918013185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918013186 active site 189918013187 ATP binding site [chemical binding]; other site 189918013188 substrate binding site [chemical binding]; other site 189918013189 activation loop (A-loop); other site 189918013190 Kelch motif; Region: Kelch_6; pfam13964 189918013191 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189918013192 Kelch domain; Region: Kelch; smart00612 189918013193 Kelch motif; Region: Kelch_1; pfam01344 189918013194 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189918013195 Kelch motif; Region: Kelch_1; pfam01344 189918013196 Kelch domain; Region: Kelch; smart00612 189918013197 Kelch motif; Region: Kelch_1; pfam01344 189918013198 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189918013199 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 189918013200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 189918013201 active site 189918013202 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 189918013203 RNA/DNA hybrid binding site [nucleotide binding]; other site 189918013204 active site 189918013205 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918013206 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918013207 active site 189918013208 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 189918013209 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 189918013210 nucleotide binding site [chemical binding]; other site 189918013211 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 189918013212 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 189918013213 active site 189918013214 DNA binding site [nucleotide binding] 189918013215 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 189918013216 DNA binding site [nucleotide binding] 189918013217 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 189918013218 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 189918013219 Walker A/P-loop; other site 189918013220 ATP binding site [chemical binding]; other site 189918013221 Q-loop/lid; other site 189918013222 ABC transporter signature motif; other site 189918013223 Walker B; other site 189918013224 D-loop; other site 189918013225 H-loop/switch region; other site 189918013226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 189918013227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918013228 dimer interface [polypeptide binding]; other site 189918013229 conserved gate region; other site 189918013230 putative PBP binding loops; other site 189918013231 ABC-ATPase subunit interface; other site 189918013232 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189918013233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918013234 dimer interface [polypeptide binding]; other site 189918013235 putative PBP binding loops; other site 189918013236 ABC-ATPase subunit interface; other site 189918013237 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 189918013238 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 189918013239 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 189918013240 MarR family; Region: MarR_2; pfam12802 189918013241 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 189918013242 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 189918013243 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 189918013244 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 189918013245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 189918013246 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 189918013247 putative substrate binding site [chemical binding]; other site 189918013248 putative ATP binding site [chemical binding]; other site 189918013249 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 189918013250 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 189918013251 putative DNA binding site [nucleotide binding]; other site 189918013252 putative homodimer interface [polypeptide binding]; other site 189918013253 short chain dehydrogenase; Provisional; Region: PRK07814 189918013254 classical (c) SDRs; Region: SDR_c; cd05233 189918013255 NAD(P) binding site [chemical binding]; other site 189918013256 active site 189918013257 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918013258 manganese transport protein MntH; Reviewed; Region: PRK00701 189918013259 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 189918013260 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 189918013261 putative active site pocket [active] 189918013262 dimerization interface [polypeptide binding]; other site 189918013263 putative catalytic residue [active] 189918013264 Protein of unknown function (DUF867); Region: DUF867; pfam05908 189918013265 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 189918013266 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 189918013267 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 189918013268 active site 189918013269 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 189918013270 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 189918013271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918013272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918013273 DNA binding residues [nucleotide binding] 189918013274 putative anti-sigmaE protein; Provisional; Region: PRK13920 189918013275 Anti-sigma-K factor rskA; Region: RskA; pfam10099 189918013276 carboxylate-amine ligase; Provisional; Region: PRK13517 189918013277 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 189918013278 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 189918013279 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 189918013280 Subunit I/III interface [polypeptide binding]; other site 189918013281 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918013282 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 189918013283 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 189918013284 putative dimer interface [polypeptide binding]; other site 189918013285 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 189918013286 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 189918013287 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918013288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918013289 DNA-binding site [nucleotide binding]; DNA binding site 189918013290 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 189918013291 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 189918013292 Cysteine-rich domain; Region: CCG; pfam02754 189918013293 Cysteine-rich domain; Region: CCG; pfam02754 189918013294 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 189918013295 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 189918013296 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 189918013297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 189918013298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 189918013299 DNA binding site [nucleotide binding] 189918013300 domain linker motif; other site 189918013301 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 189918013302 ligand binding site [chemical binding]; other site 189918013303 dimerization interface [polypeptide binding]; other site 189918013304 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 189918013305 N- and C-terminal domain interface [polypeptide binding]; other site 189918013306 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 189918013307 active site 189918013308 putative catalytic site [active] 189918013309 metal binding site [ion binding]; metal-binding site 189918013310 ATP binding site [chemical binding]; other site 189918013311 carbohydrate binding site [chemical binding]; other site 189918013312 short chain dehydrogenase; Validated; Region: PRK08324 189918013313 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 189918013314 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 189918013315 putative NAD(P) binding site [chemical binding]; other site 189918013316 active site 189918013317 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 189918013318 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 189918013319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918013320 putative substrate translocation pore; other site 189918013321 Domain of unknown function (DUF718); Region: DUF718; pfam05336 189918013322 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 189918013323 active site 189918013324 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 189918013325 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918013326 NAD binding site [chemical binding]; other site 189918013327 catalytic residues [active] 189918013328 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 189918013329 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 189918013330 PYR/PP interface [polypeptide binding]; other site 189918013331 dimer interface [polypeptide binding]; other site 189918013332 TPP binding site [chemical binding]; other site 189918013333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 189918013334 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 189918013335 TPP-binding site; other site 189918013336 dimer interface [polypeptide binding]; other site 189918013337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013338 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918013339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918013340 active site 189918013341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918013343 active site 189918013344 enoyl-CoA hydratase; Provisional; Region: PRK06688 189918013345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013346 substrate binding site [chemical binding]; other site 189918013347 oxyanion hole (OAH) forming residues; other site 189918013348 trimer interface [polypeptide binding]; other site 189918013349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189918013350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189918013351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189918013352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918013353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918013355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013356 active site 189918013357 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918013358 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918013359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013360 NAD(P) binding site [chemical binding]; other site 189918013361 active site 189918013362 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918013363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918013364 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918013365 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189918013366 [2Fe-2S] cluster binding site [ion binding]; other site 189918013367 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189918013368 hydrophobic ligand binding site; other site 189918013369 classical (c) SDRs; Region: SDR_c; cd05233 189918013370 NAD(P) binding site [chemical binding]; other site 189918013371 active site 189918013372 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 189918013373 PQQ-like domain; Region: PQQ_2; pfam13360 189918013374 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 189918013375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918013376 DNA-binding site [nucleotide binding]; DNA binding site 189918013377 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 189918013378 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 189918013379 AMP-binding enzyme; Region: AMP-binding; pfam00501 189918013380 acyl-activating enzyme (AAE) consensus motif; other site 189918013381 putative AMP binding site [chemical binding]; other site 189918013382 putative active site [active] 189918013383 putative CoA binding site [chemical binding]; other site 189918013384 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 189918013385 classical (c) SDRs; Region: SDR_c; cd05233 189918013386 NAD(P) binding site [chemical binding]; other site 189918013387 active site 189918013388 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918013389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013390 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918013391 acyl-activating enzyme (AAE) consensus motif; other site 189918013392 acyl-activating enzyme (AAE) consensus motif; other site 189918013393 putative AMP binding site [chemical binding]; other site 189918013394 putative active site [active] 189918013395 putative CoA binding site [chemical binding]; other site 189918013396 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918013397 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918013398 short chain dehydrogenase; Provisional; Region: PRK07814 189918013399 classical (c) SDRs; Region: SDR_c; cd05233 189918013400 NAD(P) binding site [chemical binding]; other site 189918013401 active site 189918013402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013403 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 189918013404 metal ion-dependent adhesion site (MIDAS); other site 189918013405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918013406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189918013407 Walker A motif; other site 189918013408 ATP binding site [chemical binding]; other site 189918013409 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 189918013410 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918013411 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918013412 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918013413 Cytochrome P450; Region: p450; cl12078 189918013414 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 189918013415 NADH(P)-binding; Region: NAD_binding_10; pfam13460 189918013416 NAD(P) binding site [chemical binding]; other site 189918013417 putative active site [active] 189918013418 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918013419 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189918013420 catalytic site [active] 189918013421 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918013422 hydrophobic ligand binding site; other site 189918013423 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 189918013424 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 189918013425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918013426 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189918013427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918013428 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918013429 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 189918013430 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 189918013431 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 189918013432 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189918013433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013434 substrate binding site [chemical binding]; other site 189918013435 oxyanion hole (OAH) forming residues; other site 189918013436 trimer interface [polypeptide binding]; other site 189918013437 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 189918013438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 189918013439 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 189918013440 AMP-binding domain protein; Validated; Region: PRK08315 189918013441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013442 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 189918013443 acyl-activating enzyme (AAE) consensus motif; other site 189918013444 acyl-activating enzyme (AAE) consensus motif; other site 189918013445 putative AMP binding site [chemical binding]; other site 189918013446 putative active site [active] 189918013447 putative CoA binding site [chemical binding]; other site 189918013448 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 189918013449 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013450 acyl-activating enzyme (AAE) consensus motif; other site 189918013451 AMP binding site [chemical binding]; other site 189918013452 active site 189918013453 CoA binding site [chemical binding]; other site 189918013454 GAF domain; Region: GAF; pfam01590 189918013455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918013456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918013457 DNA binding residues [nucleotide binding] 189918013458 dimerization interface [polypeptide binding]; other site 189918013459 Epoxide hydrolase N terminus; Region: EHN; pfam06441 189918013460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918013461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918013462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918013463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918013464 metal binding site [ion binding]; metal-binding site 189918013465 active site 189918013466 I-site; other site 189918013467 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 189918013468 putative active site [active] 189918013469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189918013470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189918013471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918013472 Walker A/P-loop; other site 189918013473 ATP binding site [chemical binding]; other site 189918013474 Q-loop/lid; other site 189918013475 ABC transporter signature motif; other site 189918013476 Walker B; other site 189918013477 D-loop; other site 189918013478 H-loop/switch region; other site 189918013479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189918013480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189918013481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918013482 Walker A/P-loop; other site 189918013483 ATP binding site [chemical binding]; other site 189918013484 Q-loop/lid; other site 189918013485 ABC transporter signature motif; other site 189918013486 Walker B; other site 189918013487 D-loop; other site 189918013488 H-loop/switch region; other site 189918013489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189918013490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918013491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918013492 Walker A/P-loop; other site 189918013493 ATP binding site [chemical binding]; other site 189918013494 Q-loop/lid; other site 189918013495 ABC transporter signature motif; other site 189918013496 Walker B; other site 189918013497 D-loop; other site 189918013498 H-loop/switch region; other site 189918013499 Ion channel; Region: Ion_trans_2; pfam07885 189918013500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918013501 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918013502 active site 189918013503 phosphorylation site [posttranslational modification] 189918013504 intermolecular recognition site; other site 189918013505 dimerization interface [polypeptide binding]; other site 189918013506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918013507 DNA binding site [nucleotide binding] 189918013508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918013509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918013510 dimerization interface [polypeptide binding]; other site 189918013511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918013512 dimer interface [polypeptide binding]; other site 189918013513 phosphorylation site [posttranslational modification] 189918013514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918013515 ATP binding site [chemical binding]; other site 189918013516 Mg2+ binding site [ion binding]; other site 189918013517 G-X-G motif; other site 189918013518 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 189918013519 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 189918013520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918013521 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 189918013522 MarR family; Region: MarR_2; cl17246 189918013523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918013524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918013525 putative substrate translocation pore; other site 189918013526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918013527 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 189918013528 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 189918013529 dimer interface [polypeptide binding]; other site 189918013530 active site 189918013531 citrylCoA binding site [chemical binding]; other site 189918013532 NADH binding [chemical binding]; other site 189918013533 cationic pore residues; other site 189918013534 oxalacetate/citrate binding site [chemical binding]; other site 189918013535 coenzyme A binding site [chemical binding]; other site 189918013536 catalytic triad [active] 189918013537 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 189918013538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013539 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 189918013540 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 189918013541 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 189918013542 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 189918013543 dimer interface [polypeptide binding]; other site 189918013544 Citrate synthase; Region: Citrate_synt; pfam00285 189918013545 active site 189918013546 citrylCoA binding site [chemical binding]; other site 189918013547 oxalacetate/citrate binding site [chemical binding]; other site 189918013548 coenzyme A binding site [chemical binding]; other site 189918013549 catalytic triad [active] 189918013550 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 189918013551 putative dimer interface [polypeptide binding]; other site 189918013552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918013553 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 189918013554 4Fe-4S binding domain; Region: Fer4; pfam00037 189918013555 ferredoxin-NADP+ reductase; Region: PLN02852 189918013556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918013557 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 189918013558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918013559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918013560 catalytic residue [active] 189918013561 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 189918013562 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 189918013563 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189918013564 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189918013565 MarR family; Region: MarR_2; cl17246 189918013566 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 189918013567 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918013568 hydrophobic ligand binding site; other site 189918013569 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 189918013570 H+ Antiporter protein; Region: 2A0121; TIGR00900 189918013571 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 189918013572 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 189918013573 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189918013574 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 189918013575 putative dimer interface [polypeptide binding]; other site 189918013576 N-terminal domain interface [polypeptide binding]; other site 189918013577 putative substrate binding pocket (H-site) [chemical binding]; other site 189918013578 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 189918013579 DNA-binding site [nucleotide binding]; DNA binding site 189918013580 RNA-binding motif; other site 189918013581 hypothetical protein; Provisional; Region: PRK11770 189918013582 Domain of unknown function (DUF307); Region: DUF307; pfam03733 189918013583 Domain of unknown function (DUF307); Region: DUF307; pfam03733 189918013584 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 189918013585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189918013586 FeS/SAM binding site; other site 189918013587 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 189918013588 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 189918013589 MoaE interaction surface [polypeptide binding]; other site 189918013590 thiocarboxylated glycine; other site 189918013591 ydaO/yuaA element as predicted by Rfam (RF00379), score 42.62 189918013592 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 189918013593 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 189918013594 MoaE homodimer interface [polypeptide binding]; other site 189918013595 MoaD interaction [polypeptide binding]; other site 189918013596 active site residues [active] 189918013597 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 189918013598 MPT binding site; other site 189918013599 trimer interface [polypeptide binding]; other site 189918013600 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 189918013601 trimer interface [polypeptide binding]; other site 189918013602 dimer interface [polypeptide binding]; other site 189918013603 putative active site [active] 189918013604 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 189918013605 WYL domain; Region: WYL; pfam13280 189918013606 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 189918013607 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 189918013608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 189918013609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918013610 ATP binding site [chemical binding]; other site 189918013611 putative Mg++ binding site [ion binding]; other site 189918013612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918013613 nucleotide binding region [chemical binding]; other site 189918013614 ATP-binding site [chemical binding]; other site 189918013615 ethanolamine permease; Region: 2A0305; TIGR00908 189918013616 Cupin domain; Region: Cupin_2; cl17218 189918013617 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918013618 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918013619 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 189918013620 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 189918013621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013622 AMP binding site [chemical binding]; other site 189918013623 active site 189918013624 acyl-activating enzyme (AAE) consensus motif; other site 189918013625 CoA binding site [chemical binding]; other site 189918013626 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 189918013627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013628 substrate binding site [chemical binding]; other site 189918013629 oxyanion hole (OAH) forming residues; other site 189918013630 trimer interface [polypeptide binding]; other site 189918013631 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189918013632 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 189918013633 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 189918013634 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918013635 dimer interface [polypeptide binding]; other site 189918013636 active site 189918013637 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 189918013638 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 189918013639 FMN binding site [chemical binding]; other site 189918013640 active site 189918013641 substrate binding site [chemical binding]; other site 189918013642 catalytic residue [active] 189918013643 short chain dehydrogenase; Validated; Region: PRK08264 189918013644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013645 NAD(P) binding site [chemical binding]; other site 189918013646 active site 189918013647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013649 aminotransferase; Validated; Region: PRK07777 189918013650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918013651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918013652 homodimer interface [polypeptide binding]; other site 189918013653 catalytic residue [active] 189918013654 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918013655 putative hydrophobic ligand binding site [chemical binding]; other site 189918013656 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918013657 putative hydrophobic ligand binding site [chemical binding]; other site 189918013658 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918013659 putative hydrophobic ligand binding site [chemical binding]; other site 189918013660 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 189918013661 putative hydrophobic ligand binding site [chemical binding]; other site 189918013662 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 189918013663 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189918013664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013665 NAD(P) binding site [chemical binding]; other site 189918013666 active site 189918013667 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918013668 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918013669 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 189918013670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918013671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013675 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 189918013676 apolar tunnel; other site 189918013677 heme binding site [chemical binding]; other site 189918013678 dimerization interface [polypeptide binding]; other site 189918013679 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 189918013680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013682 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 189918013683 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 189918013684 homodimer interface [polypeptide binding]; other site 189918013685 putative substrate binding pocket [chemical binding]; other site 189918013686 diiron center [ion binding]; other site 189918013687 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 189918013688 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 189918013689 FMN binding site [chemical binding]; other site 189918013690 active site 189918013691 catalytic residues [active] 189918013692 substrate binding site [chemical binding]; other site 189918013693 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 189918013694 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 189918013695 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 189918013696 PhoU domain; Region: PhoU; pfam01895 189918013697 PhoU domain; Region: PhoU; pfam01895 189918013698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918013699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918013700 active site 189918013701 phosphorylation site [posttranslational modification] 189918013702 intermolecular recognition site; other site 189918013703 dimerization interface [polypeptide binding]; other site 189918013704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918013705 DNA binding site [nucleotide binding] 189918013706 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 189918013707 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 189918013708 Walker A/P-loop; other site 189918013709 ATP binding site [chemical binding]; other site 189918013710 Q-loop/lid; other site 189918013711 ABC transporter signature motif; other site 189918013712 Walker B; other site 189918013713 D-loop; other site 189918013714 H-loop/switch region; other site 189918013715 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 189918013716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918013717 dimer interface [polypeptide binding]; other site 189918013718 conserved gate region; other site 189918013719 putative PBP binding loops; other site 189918013720 ABC-ATPase subunit interface; other site 189918013721 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 189918013722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918013723 dimer interface [polypeptide binding]; other site 189918013724 conserved gate region; other site 189918013725 ABC-ATPase subunit interface; other site 189918013726 PBP superfamily domain; Region: PBP_like_2; cl17296 189918013727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918013728 putative DNA binding site [nucleotide binding]; other site 189918013729 putative Zn2+ binding site [ion binding]; other site 189918013730 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 189918013731 Low molecular weight phosphatase family; Region: LMWPc; cl00105 189918013732 active site 189918013733 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 189918013734 Low molecular weight phosphatase family; Region: LMWPc; cd00115 189918013735 active site 189918013736 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 189918013737 arsenical-resistance protein; Region: acr3; TIGR00832 189918013738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918013739 dimerization interface [polypeptide binding]; other site 189918013740 putative DNA binding site [nucleotide binding]; other site 189918013741 putative Zn2+ binding site [ion binding]; other site 189918013742 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 189918013743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189918013744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918013745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918013746 DNA binding site [nucleotide binding] 189918013747 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 189918013748 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189918013749 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918013750 catalytic residues [active] 189918013751 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 189918013752 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 189918013753 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 189918013754 active site residue [active] 189918013755 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 189918013756 active site residue [active] 189918013757 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 189918013758 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918013759 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 189918013760 heme-binding site [chemical binding]; other site 189918013761 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 189918013762 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 189918013763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918013764 catalytic residue [active] 189918013765 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 189918013766 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 189918013767 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 189918013768 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 189918013769 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 189918013770 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 189918013771 dimerization interface [polypeptide binding]; other site 189918013772 putative ATP binding site [chemical binding]; other site 189918013773 Cupin domain; Region: Cupin_2; cl17218 189918013774 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 189918013775 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 189918013776 putative NAD(P) binding site [chemical binding]; other site 189918013777 putative active site [active] 189918013778 amidophosphoribosyltransferase; Provisional; Region: PRK07847 189918013779 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 189918013780 active site 189918013781 tetramer interface [polypeptide binding]; other site 189918013782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918013783 active site 189918013784 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013785 mce related protein; Region: MCE; pfam02470 189918013786 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918013787 CAAX protease self-immunity; Region: Abi; pfam02517 189918013788 Predicted membrane protein [Function unknown]; Region: COG4425 189918013789 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 189918013790 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 189918013791 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 189918013792 dimerization interface [polypeptide binding]; other site 189918013793 ATP binding site [chemical binding]; other site 189918013794 Uncharacterized conserved protein [Function unknown]; Region: COG3375 189918013795 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 189918013796 dimerization interface [polypeptide binding]; other site 189918013797 ATP binding site [chemical binding]; other site 189918013798 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 189918013799 PE-PPE domain; Region: PE-PPE; pfam08237 189918013800 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918013801 active site 189918013802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918013803 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 189918013804 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 189918013805 active site 189918013806 metal binding site [ion binding]; metal-binding site 189918013807 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 189918013808 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 189918013809 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 189918013810 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 189918013811 putative active site [active] 189918013812 catalytic triad [active] 189918013813 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 189918013814 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 189918013815 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918013816 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 189918013817 Predicted deacetylase [General function prediction only]; Region: COG3233 189918013818 putative active site [active] 189918013819 putative Zn binding site [ion binding]; other site 189918013820 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 189918013821 catalytic residues [active] 189918013822 dimer interface [polypeptide binding]; other site 189918013823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918013825 WHG domain; Region: WHG; pfam13305 189918013826 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 189918013827 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 189918013828 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 189918013829 ATP binding site [chemical binding]; other site 189918013830 active site 189918013831 substrate binding site [chemical binding]; other site 189918013832 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189918013833 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 189918013834 DXD motif; other site 189918013835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013836 NAD(P) binding site [chemical binding]; other site 189918013837 active site 189918013838 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918013839 Cytochrome P450; Region: p450; cl12078 189918013840 adenylosuccinate lyase; Region: purB; TIGR00928 189918013841 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 189918013842 tetramer interface [polypeptide binding]; other site 189918013843 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 189918013844 amino acid transporter; Region: 2A0306; TIGR00909 189918013845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 189918013846 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 189918013847 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 189918013848 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 189918013849 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 189918013850 Cytochrome P450; Region: p450; cl12078 189918013851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918013852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918013853 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 189918013854 DNA-binding interface [nucleotide binding]; DNA binding site 189918013855 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 189918013856 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918013857 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918013858 short chain dehydrogenase; Provisional; Region: PRK07774 189918013859 classical (c) SDRs; Region: SDR_c; cd05233 189918013860 NAD(P) binding site [chemical binding]; other site 189918013861 active site 189918013862 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 189918013863 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 189918013864 NAD binding site [chemical binding]; other site 189918013865 catalytic residues [active] 189918013866 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918013867 Cytochrome P450; Region: p450; cl12078 189918013868 short chain dehydrogenase; Provisional; Region: PRK07775 189918013869 classical (c) SDRs; Region: SDR_c; cd05233 189918013870 NAD(P) binding site [chemical binding]; other site 189918013871 active site 189918013872 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918013873 Cytochrome P450; Region: p450; cl12078 189918013874 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918013875 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918013876 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 189918013877 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918013878 NAD binding site [chemical binding]; other site 189918013879 catalytic Zn binding site [ion binding]; other site 189918013880 substrate binding site [chemical binding]; other site 189918013881 structural Zn binding site [ion binding]; other site 189918013882 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918013883 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189918013884 classical (c) SDRs; Region: SDR_c; cd05233 189918013885 NAD(P) binding site [chemical binding]; other site 189918013886 active site 189918013887 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 189918013888 nucleotide binding site/active site [active] 189918013889 HIT family signature motif; other site 189918013890 catalytic residue [active] 189918013891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918013892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 189918013893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189918013894 dimer interface [polypeptide binding]; other site 189918013895 phosphorylation site [posttranslational modification] 189918013896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918013897 ATP binding site [chemical binding]; other site 189918013898 Mg2+ binding site [ion binding]; other site 189918013899 G-X-G motif; other site 189918013900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189918013901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918013902 active site 189918013903 phosphorylation site [posttranslational modification] 189918013904 intermolecular recognition site; other site 189918013905 dimerization interface [polypeptide binding]; other site 189918013906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189918013907 DNA binding site [nucleotide binding] 189918013908 HNH endonuclease; Region: HNH_3; pfam13392 189918013909 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 189918013910 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918013911 trehalose synthase; Region: treS_nterm; TIGR02456 189918013912 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 189918013913 active site 189918013914 catalytic site [active] 189918013915 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 189918013916 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 189918013917 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 189918013918 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 189918013919 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 189918013920 putative hydrophobic ligand binding site [chemical binding]; other site 189918013921 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 189918013922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 189918013923 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 189918013924 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918013925 catalytic loop [active] 189918013926 iron binding site [ion binding]; other site 189918013927 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 189918013928 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918013929 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918013930 short chain dehydrogenase; Provisional; Region: PRK05875 189918013931 classical (c) SDRs; Region: SDR_c; cd05233 189918013932 NAD(P) binding site [chemical binding]; other site 189918013933 active site 189918013934 enoyl-CoA hydratase; Provisional; Region: PRK08290 189918013935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013936 substrate binding site [chemical binding]; other site 189918013937 oxyanion hole (OAH) forming residues; other site 189918013938 trimer interface [polypeptide binding]; other site 189918013939 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 189918013940 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 189918013941 active site 189918013942 homotetramer interface [polypeptide binding]; other site 189918013943 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013944 mce related protein; Region: MCE; pfam02470 189918013945 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013946 mce related protein; Region: MCE; pfam02470 189918013947 mce related protein; Region: MCE; pfam02470 189918013948 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918013949 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013950 mce related protein; Region: MCE; pfam02470 189918013951 Vps51/Vps67; Region: Vps51; pfam08700 189918013952 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013953 mce related protein; Region: MCE; pfam02470 189918013954 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918013955 mce related protein; Region: MCE; pfam02470 189918013956 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918013957 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918013958 Permease; Region: Permease; pfam02405 189918013959 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 189918013960 Permease; Region: Permease; pfam02405 189918013961 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 189918013962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918013963 NAD(P) binding site [chemical binding]; other site 189918013964 active site 189918013965 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 189918013966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013967 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 189918013968 FAD binding site [chemical binding]; other site 189918013969 substrate binding site [chemical binding]; other site 189918013970 catalytic base [active] 189918013971 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918013972 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918013973 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918013974 active site 189918013975 acyl-CoA synthetase; Validated; Region: PRK07867 189918013976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013977 acyl-activating enzyme (AAE) consensus motif; other site 189918013978 AMP binding site [chemical binding]; other site 189918013979 active site 189918013980 CoA binding site [chemical binding]; other site 189918013981 Nitronate monooxygenase; Region: NMO; pfam03060 189918013982 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918013983 FMN binding site [chemical binding]; other site 189918013984 substrate binding site [chemical binding]; other site 189918013985 putative catalytic residue [active] 189918013986 acyl-CoA synthetase; Validated; Region: PRK07798 189918013987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918013988 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 189918013989 acyl-activating enzyme (AAE) consensus motif; other site 189918013990 acyl-activating enzyme (AAE) consensus motif; other site 189918013991 putative AMP binding site [chemical binding]; other site 189918013992 putative active site [active] 189918013993 putative CoA binding site [chemical binding]; other site 189918013994 enoyl-CoA hydratase; Provisional; Region: PRK07799 189918013995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918013996 substrate binding site [chemical binding]; other site 189918013997 oxyanion hole (OAH) forming residues; other site 189918013998 trimer interface [polypeptide binding]; other site 189918013999 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 189918014000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014001 Cytochrome P450; Region: p450; cl12078 189918014002 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 189918014003 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918014004 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 189918014005 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 189918014006 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918014007 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 189918014008 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918014009 lipid-transfer protein; Provisional; Region: PRK07937 189918014010 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918014011 active site 189918014012 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 189918014013 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918014014 active site 189918014015 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918014016 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918014017 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 189918014018 MOSC domain; Region: MOSC; pfam03473 189918014019 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 189918014020 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 189918014021 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 189918014022 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189918014023 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 189918014024 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 189918014025 DXD motif; other site 189918014026 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 189918014027 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 189918014028 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 189918014029 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 189918014030 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 189918014031 short chain dehydrogenase; Provisional; Region: PRK07890 189918014032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014033 NAD(P) binding site [chemical binding]; other site 189918014034 active site 189918014035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918014036 putative DNA binding site [nucleotide binding]; other site 189918014037 Transcriptional regulator [Transcription]; Region: IclR; COG1414 189918014038 putative Zn2+ binding site [ion binding]; other site 189918014039 acyl-CoA synthetase; Provisional; Region: PRK13390 189918014040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918014041 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 189918014042 acyl-activating enzyme (AAE) consensus motif; other site 189918014043 putative AMP binding site [chemical binding]; other site 189918014044 putative active site [active] 189918014045 acyl-activating enzyme (AAE) consensus motif; other site 189918014046 putative CoA binding site [chemical binding]; other site 189918014047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 189918014048 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 189918014049 NAD(P) binding site [chemical binding]; other site 189918014050 catalytic residues [active] 189918014051 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 189918014052 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918014053 NAD binding site [chemical binding]; other site 189918014054 catalytic Zn binding site [ion binding]; other site 189918014055 substrate binding site [chemical binding]; other site 189918014056 structural Zn binding site [ion binding]; other site 189918014057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014058 Cytochrome P450; Region: p450; cl12078 189918014059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189918014060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918014061 ATP binding site [chemical binding]; other site 189918014062 Mg2+ binding site [ion binding]; other site 189918014063 G-X-G motif; other site 189918014064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918014065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189918014066 active site 189918014067 phosphorylation site [posttranslational modification] 189918014068 intermolecular recognition site; other site 189918014069 dimerization interface [polypeptide binding]; other site 189918014070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918014071 DNA binding residues [nucleotide binding] 189918014072 dimerization interface [polypeptide binding]; other site 189918014073 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918014074 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 189918014075 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 189918014076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918014077 ATP binding site [chemical binding]; other site 189918014078 putative Mg++ binding site [ion binding]; other site 189918014079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918014080 nucleotide binding region [chemical binding]; other site 189918014081 ATP-binding site [chemical binding]; other site 189918014082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918014083 active site 189918014084 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 189918014085 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 189918014086 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 189918014087 active site 189918014088 catalytic residues [active] 189918014089 metal binding site [ion binding]; metal-binding site 189918014090 DmpG-like communication domain; Region: DmpG_comm; pfam07836 189918014091 acetaldehyde dehydrogenase; Validated; Region: PRK08300 189918014092 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 189918014093 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 189918014094 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 189918014095 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 189918014096 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918014097 enoyl-CoA hydratase; Region: PLN02864 189918014098 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 189918014099 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 189918014100 dimer interaction site [polypeptide binding]; other site 189918014101 substrate-binding tunnel; other site 189918014102 active site 189918014103 catalytic site [active] 189918014104 substrate binding site [chemical binding]; other site 189918014105 SnoaL-like domain; Region: SnoaL_4; pfam13577 189918014106 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 189918014107 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 189918014108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189918014109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189918014110 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 189918014111 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 189918014112 putative active site [active] 189918014113 putative metal binding site [ion binding]; other site 189918014114 lipid-transfer protein; Provisional; Region: PRK07855 189918014115 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189918014116 active site 189918014117 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 189918014118 putative active site [active] 189918014119 putative catalytic site [active] 189918014120 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918014121 active site 189918014122 catalytic site [active] 189918014123 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 189918014124 DUF35 OB-fold domain; Region: DUF35; pfam01796 189918014125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014127 active site 189918014128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014130 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014131 Cytochrome P450; Region: p450; cl12078 189918014132 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 189918014133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918014134 dimer interface [polypeptide binding]; other site 189918014135 active site 189918014136 Domain of unknown function (DUF385); Region: DUF385; pfam04075 189918014137 short chain dehydrogenase; Provisional; Region: PRK07791 189918014138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014139 NAD(P) binding site [chemical binding]; other site 189918014140 active site 189918014141 short chain dehydrogenase; Provisional; Region: PRK07856 189918014142 classical (c) SDRs; Region: SDR_c; cd05233 189918014143 NAD(P) binding site [chemical binding]; other site 189918014144 active site 189918014145 enoyl-CoA hydratase; Provisional; Region: PRK06495 189918014146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918014147 substrate binding site [chemical binding]; other site 189918014148 oxyanion hole (OAH) forming residues; other site 189918014149 trimer interface [polypeptide binding]; other site 189918014150 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 189918014151 Coenzyme A transferase; Region: CoA_trans; cl17247 189918014152 Nitronate monooxygenase; Region: NMO; pfam03060 189918014153 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189918014154 FMN binding site [chemical binding]; other site 189918014155 substrate binding site [chemical binding]; other site 189918014156 putative catalytic residue [active] 189918014157 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 189918014158 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 189918014159 NAD binding site [chemical binding]; other site 189918014160 catalytic Zn binding site [ion binding]; other site 189918014161 substrate binding site [chemical binding]; other site 189918014162 structural Zn binding site [ion binding]; other site 189918014163 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 189918014164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189918014165 dimer interface [polypeptide binding]; other site 189918014166 active site 189918014167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014169 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 189918014170 short chain dehydrogenase; Provisional; Region: PRK07831 189918014171 classical (c) SDRs; Region: SDR_c; cd05233 189918014172 NAD(P) binding site [chemical binding]; other site 189918014173 active site 189918014174 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014175 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014176 active site 189918014177 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 189918014178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918014179 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 189918014180 acyl-activating enzyme (AAE) consensus motif; other site 189918014181 putative AMP binding site [chemical binding]; other site 189918014182 putative active site [active] 189918014183 putative CoA binding site [chemical binding]; other site 189918014184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014185 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 189918014186 FAD binding site [chemical binding]; other site 189918014187 substrate binding site [chemical binding]; other site 189918014188 catalytic base [active] 189918014189 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918014190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014192 active site 189918014193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014195 active site 189918014196 aspartate aminotransferase; Provisional; Region: PRK05764 189918014197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918014198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918014199 homodimer interface [polypeptide binding]; other site 189918014200 catalytic residue [active] 189918014201 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918014202 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 189918014203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918014204 acyl-activating enzyme (AAE) consensus motif; other site 189918014205 AMP binding site [chemical binding]; other site 189918014206 active site 189918014207 CoA binding site [chemical binding]; other site 189918014208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014209 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 189918014210 NAD(P) binding site [chemical binding]; other site 189918014211 active site 189918014212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918014213 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918014214 putative substrate translocation pore; other site 189918014215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918014216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918014217 LysR substrate binding domain; Region: LysR_substrate; pfam03466 189918014218 dimerization interface [polypeptide binding]; other site 189918014219 CsbD-like; Region: CsbD; pfam05532 189918014220 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 189918014221 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 189918014222 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 189918014223 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 189918014224 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 189918014225 active site 189918014226 Fe binding site [ion binding]; other site 189918014227 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 189918014228 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918014229 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918014230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014231 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 189918014232 Flavin binding site [chemical binding]; other site 189918014233 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 189918014234 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 189918014235 FAD binding pocket [chemical binding]; other site 189918014236 FAD binding motif [chemical binding]; other site 189918014237 phosphate binding motif [ion binding]; other site 189918014238 beta-alpha-beta structure motif; other site 189918014239 NAD(p) ribose binding residues [chemical binding]; other site 189918014240 NAD binding pocket [chemical binding]; other site 189918014241 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 189918014242 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189918014243 catalytic loop [active] 189918014244 iron binding site [ion binding]; other site 189918014245 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918014246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014247 active site 189918014248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918014249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918014250 active site 189918014251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014253 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 189918014254 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 189918014255 Phosphotransferase enzyme family; Region: APH; pfam01636 189918014256 Transcriptional regulators [Transcription]; Region: PurR; COG1609 189918014257 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 189918014258 DNA binding site [nucleotide binding] 189918014259 domain linker motif; other site 189918014260 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 189918014261 putative dimerization interface [polypeptide binding]; other site 189918014262 putative ligand binding site [chemical binding]; other site 189918014263 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 189918014264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 189918014265 ABC-ATPase subunit interface; other site 189918014266 dimer interface [polypeptide binding]; other site 189918014267 putative PBP binding regions; other site 189918014268 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 189918014269 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 189918014270 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 189918014271 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 189918014272 intersubunit interface [polypeptide binding]; other site 189918014273 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 189918014274 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 189918014275 active site residue [active] 189918014276 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189918014277 active site residue [active] 189918014278 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 189918014279 putative FMN binding site [chemical binding]; other site 189918014280 PQQ-like domain; Region: PQQ_2; pfam13360 189918014281 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 189918014282 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 189918014283 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 189918014284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 189918014285 ABC-ATPase subunit interface; other site 189918014286 dimer interface [polypeptide binding]; other site 189918014287 putative PBP binding regions; other site 189918014288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918014289 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 189918014290 Walker A/P-loop; other site 189918014291 ATP binding site [chemical binding]; other site 189918014292 Q-loop/lid; other site 189918014293 ABC transporter signature motif; other site 189918014294 Walker B; other site 189918014295 D-loop; other site 189918014296 H-loop/switch region; other site 189918014297 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 189918014298 putative active site [active] 189918014299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918014300 dimerization interface [polypeptide binding]; other site 189918014301 putative DNA binding site [nucleotide binding]; other site 189918014302 putative Zn2+ binding site [ion binding]; other site 189918014303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918014304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189918014305 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 189918014306 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 189918014307 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 189918014308 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 189918014309 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 189918014310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918014311 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 189918014312 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 189918014313 active site 189918014314 catalytic site [active] 189918014315 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 189918014316 transmembrane helices; other site 189918014317 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189918014318 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 189918014319 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189918014320 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 189918014321 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 189918014322 active site 189918014323 HIGH motif; other site 189918014324 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 189918014325 KMSKS motif; other site 189918014326 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 189918014327 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 189918014328 homotrimer interaction site [polypeptide binding]; other site 189918014329 zinc binding site [ion binding]; other site 189918014330 CDP-binding sites; other site 189918014331 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 189918014332 substrate binding site; other site 189918014333 dimer interface; other site 189918014334 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 189918014335 DNA repair protein RadA; Provisional; Region: PRK11823 189918014336 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189918014337 Walker A motif; other site 189918014338 ATP binding site [chemical binding]; other site 189918014339 Walker B motif; other site 189918014340 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 189918014341 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 189918014342 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 189918014343 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 189918014344 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 189918014345 active site clefts [active] 189918014346 zinc binding site [ion binding]; other site 189918014347 dimer interface [polypeptide binding]; other site 189918014348 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189918014349 endonuclease III; Region: ENDO3c; smart00478 189918014350 minor groove reading motif; other site 189918014351 helix-hairpin-helix signature motif; other site 189918014352 substrate binding pocket [chemical binding]; other site 189918014353 active site 189918014354 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 189918014355 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189918014356 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189918014357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918014358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918014359 metal binding site [ion binding]; metal-binding site 189918014360 active site 189918014361 I-site; other site 189918014362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189918014363 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 189918014364 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 189918014365 conserved cys residue [active] 189918014366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918014367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918014368 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918014369 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189918014370 catalytic site [active] 189918014371 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 189918014372 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 189918014373 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 189918014374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918014375 catalytic core [active] 189918014376 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 189918014377 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 189918014378 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 189918014379 Clp amino terminal domain; Region: Clp_N; pfam02861 189918014380 Clp amino terminal domain; Region: Clp_N; pfam02861 189918014381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918014382 Walker A motif; other site 189918014383 ATP binding site [chemical binding]; other site 189918014384 Walker B motif; other site 189918014385 arginine finger; other site 189918014386 UvrB/uvrC motif; Region: UVR; pfam02151 189918014387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918014388 Walker A motif; other site 189918014389 ATP binding site [chemical binding]; other site 189918014390 Walker B motif; other site 189918014391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 189918014392 Lsr2; Region: Lsr2; pfam11774 189918014393 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 189918014394 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 189918014395 dimer interface [polypeptide binding]; other site 189918014396 putative anticodon binding site; other site 189918014397 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189918014398 motif 1; other site 189918014399 dimer interface [polypeptide binding]; other site 189918014400 active site 189918014401 motif 2; other site 189918014402 motif 3; other site 189918014403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 189918014404 dimer interface [polypeptide binding]; other site 189918014405 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 189918014406 active site 189918014407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189918014408 substrate binding site [chemical binding]; other site 189918014409 catalytic residue [active] 189918014410 pantothenate kinase; Reviewed; Region: PRK13318 189918014411 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 189918014412 tetramerization interface [polypeptide binding]; other site 189918014413 active site 189918014414 Pantoate-beta-alanine ligase; Region: PanC; cd00560 189918014415 pantoate--beta-alanine ligase; Region: panC; TIGR00018 189918014416 active site 189918014417 ATP-binding site [chemical binding]; other site 189918014418 pantoate-binding site; other site 189918014419 HXXH motif; other site 189918014420 Rossmann-like domain; Region: Rossmann-like; pfam10727 189918014421 Uncharacterized conserved protein [Function unknown]; Region: COG5495 189918014422 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 189918014423 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 189918014424 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 189918014425 catalytic center binding site [active] 189918014426 ATP binding site [chemical binding]; other site 189918014427 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 189918014428 homooctamer interface [polypeptide binding]; other site 189918014429 active site 189918014430 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 189918014431 dihydropteroate synthase; Region: DHPS; TIGR01496 189918014432 substrate binding pocket [chemical binding]; other site 189918014433 dimer interface [polypeptide binding]; other site 189918014434 inhibitor binding site; inhibition site 189918014435 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 189918014436 homodecamer interface [polypeptide binding]; other site 189918014437 GTP cyclohydrolase I; Provisional; Region: PLN03044 189918014438 active site 189918014439 putative catalytic site residues [active] 189918014440 zinc binding site [ion binding]; other site 189918014441 GTP-CH-I/GFRP interaction surface; other site 189918014442 FtsH Extracellular; Region: FtsH_ext; pfam06480 189918014443 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 189918014444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918014445 Walker A motif; other site 189918014446 ATP binding site [chemical binding]; other site 189918014447 Walker B motif; other site 189918014448 arginine finger; other site 189918014449 Peptidase family M41; Region: Peptidase_M41; pfam01434 189918014450 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918014451 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189918014452 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918014453 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 189918014454 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918014455 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 189918014456 putative NAD(P) binding site [chemical binding]; other site 189918014457 catalytic Zn binding site [ion binding]; other site 189918014458 Uncharacterized conserved protein [Function unknown]; Region: COG2968 189918014459 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 189918014460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918014461 active site 189918014462 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 189918014463 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 189918014464 Ligand Binding Site [chemical binding]; other site 189918014465 TilS substrate binding domain; Region: TilS; pfam09179 189918014466 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 189918014467 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 189918014468 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 189918014469 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 189918014470 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 189918014471 dimer interface [polypeptide binding]; other site 189918014472 substrate binding site [chemical binding]; other site 189918014473 metal binding sites [ion binding]; metal-binding site 189918014474 putative OHCU decarboxylase; Provisional; Region: PRK13798 189918014475 allantoicase; Provisional; Region: PRK13257 189918014476 Allantoicase repeat; Region: Allantoicase; pfam03561 189918014477 Allantoicase repeat; Region: Allantoicase; pfam03561 189918014478 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 189918014479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 189918014480 putative active site [active] 189918014481 putative metal binding site [ion binding]; other site 189918014482 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 189918014483 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 189918014484 dimer interface [polypeptide binding]; other site 189918014485 NADP binding site [chemical binding]; other site 189918014486 catalytic residues [active] 189918014487 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 189918014488 yybP-ykoY element as predicted by Rfam (RF00080), score 51.99 189918014489 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 189918014490 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 189918014491 acyl-activating enzyme (AAE) consensus motif; other site 189918014492 AMP binding site [chemical binding]; other site 189918014493 active site 189918014494 CoA binding site [chemical binding]; other site 189918014495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 189918014496 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 189918014497 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 189918014498 putative CoA binding site [chemical binding]; other site 189918014499 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 189918014500 putative trimer interface [polypeptide binding]; other site 189918014501 putative CoA binding site [chemical binding]; other site 189918014502 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 189918014503 Zn binding site [ion binding]; other site 189918014504 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 189918014505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014506 NAD(P) binding site [chemical binding]; other site 189918014507 active site 189918014508 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl00172 189918014509 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 189918014510 DNA polymerase III subunit delta'; Validated; Region: PRK07940 189918014511 DNA polymerase III subunit delta'; Validated; Region: PRK08485 189918014512 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 189918014513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189918014514 dimerization interface [polypeptide binding]; other site 189918014515 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189918014516 cyclase homology domain; Region: CHD; cd07302 189918014517 nucleotidyl binding site; other site 189918014518 metal binding site [ion binding]; metal-binding site 189918014519 dimer interface [polypeptide binding]; other site 189918014520 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 189918014521 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 189918014522 active site 189918014523 interdomain interaction site; other site 189918014524 putative metal-binding site [ion binding]; other site 189918014525 nucleotide binding site [chemical binding]; other site 189918014526 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 189918014527 domain I; other site 189918014528 phosphate binding site [ion binding]; other site 189918014529 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 189918014530 domain II; other site 189918014531 domain III; other site 189918014532 nucleotide binding site [chemical binding]; other site 189918014533 DNA binding groove [nucleotide binding] 189918014534 catalytic site [active] 189918014535 domain IV; other site 189918014536 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 189918014537 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 189918014538 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 189918014539 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 189918014540 DNA-binding site [nucleotide binding]; DNA binding site 189918014541 RNA-binding motif; other site 189918014542 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 189918014543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918014544 ATP binding site [chemical binding]; other site 189918014545 putative Mg++ binding site [ion binding]; other site 189918014546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918014547 nucleotide binding region [chemical binding]; other site 189918014548 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 189918014549 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 189918014550 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 189918014551 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 189918014552 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 189918014553 ATP binding site [chemical binding]; other site 189918014554 Walker A motif; other site 189918014555 hexamer interface [polypeptide binding]; other site 189918014556 Walker B motif; other site 189918014557 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 189918014558 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 189918014559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918014560 motif II; other site 189918014561 acetyl-CoA synthetase; Provisional; Region: PRK00174 189918014562 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 189918014563 active site 189918014564 CoA binding site [chemical binding]; other site 189918014565 acyl-activating enzyme (AAE) consensus motif; other site 189918014566 AMP binding site [chemical binding]; other site 189918014567 acetate binding site [chemical binding]; other site 189918014568 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 189918014569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918014570 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189918014571 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189918014572 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 189918014573 putative active site [active] 189918014574 putative CoA binding site [chemical binding]; other site 189918014575 nudix motif; other site 189918014576 metal binding site [ion binding]; metal-binding site 189918014577 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189918014578 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918014579 catalytic residues [active] 189918014580 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 189918014581 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189918014582 minor groove reading motif; other site 189918014583 helix-hairpin-helix signature motif; other site 189918014584 substrate binding pocket [chemical binding]; other site 189918014585 active site 189918014586 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 189918014587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189918014588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189918014589 ligand binding site [chemical binding]; other site 189918014590 flexible hinge region; other site 189918014591 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 189918014592 putative switch regulator; other site 189918014593 non-specific DNA interactions [nucleotide binding]; other site 189918014594 DNA binding site [nucleotide binding] 189918014595 sequence specific DNA binding site [nucleotide binding]; other site 189918014596 putative cAMP binding site [chemical binding]; other site 189918014597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918014598 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 189918014599 homotrimer interaction site [polypeptide binding]; other site 189918014600 putative active site [active] 189918014601 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 189918014602 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 189918014603 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 189918014604 P loop; other site 189918014605 Nucleotide binding site [chemical binding]; other site 189918014606 DTAP/Switch II; other site 189918014607 Switch I; other site 189918014608 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 189918014609 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 189918014610 DTAP/Switch II; other site 189918014611 Switch I; other site 189918014612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918014613 Transcription factor WhiB; Region: Whib; pfam02467 189918014614 Transglycosylase; Region: Transgly; pfam00912 189918014615 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 189918014616 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189918014617 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189918014618 phosphodiesterase YaeI; Provisional; Region: PRK11340 189918014619 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 189918014620 putative active site [active] 189918014621 putative metal binding site [ion binding]; other site 189918014622 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 189918014623 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 189918014624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918014625 catalytic residue [active] 189918014626 Helix-turn-helix domain; Region: HTH_17; pfam12728 189918014627 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918014628 MULE transposase domain; Region: MULE; pfam10551 189918014629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014631 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918014632 CoenzymeA binding site [chemical binding]; other site 189918014633 subunit interaction site [polypeptide binding]; other site 189918014634 PHB binding site; other site 189918014635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014637 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918014638 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 189918014639 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 189918014640 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918014641 active site 189918014642 ATP binding site [chemical binding]; other site 189918014643 substrate binding site [chemical binding]; other site 189918014644 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918014645 substrate binding site [chemical binding]; other site 189918014646 activation loop (A-loop); other site 189918014647 activation loop (A-loop); other site 189918014648 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918014649 MULE transposase domain; Region: MULE; pfam10551 189918014650 Cytochrome P450; Region: p450; cl12078 189918014651 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014652 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 189918014653 active site 189918014654 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 189918014655 catalytic triad [active] 189918014656 dimer interface [polypeptide binding]; other site 189918014657 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 189918014658 putative methyltransferase; Provisional; Region: PRK14967 189918014659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918014660 S-adenosylmethionine binding site [chemical binding]; other site 189918014661 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918014662 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 189918014663 Yqey-like protein; Region: YqeY; pfam09424 189918014664 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 189918014665 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 189918014666 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918014667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918014668 Walker A motif; other site 189918014669 ATP binding site [chemical binding]; other site 189918014670 Walker B motif; other site 189918014671 arginine finger; other site 189918014672 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 189918014673 Protein of unknown function DUF58; Region: DUF58; pfam01882 189918014674 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 189918014675 Predicted membrane protein/domain [Function unknown]; Region: COG1714 189918014676 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 189918014677 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 189918014678 putative active site [active] 189918014679 putative FMN binding site [chemical binding]; other site 189918014680 putative substrate binding site [chemical binding]; other site 189918014681 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 189918014682 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 189918014683 dimer interface [polypeptide binding]; other site 189918014684 PYR/PP interface [polypeptide binding]; other site 189918014685 TPP binding site [chemical binding]; other site 189918014686 substrate binding site [chemical binding]; other site 189918014687 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 189918014688 Domain of unknown function; Region: EKR; pfam10371 189918014689 4Fe-4S binding domain; Region: Fer4_6; pfam12837 189918014690 4Fe-4S binding domain; Region: Fer4; pfam00037 189918014691 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 189918014692 TPP-binding site [chemical binding]; other site 189918014693 dimer interface [polypeptide binding]; other site 189918014694 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 189918014695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918014696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918014697 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 189918014698 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 189918014699 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 189918014700 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918014701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918014702 DNA-binding site [nucleotide binding]; DNA binding site 189918014703 FCD domain; Region: FCD; pfam07729 189918014704 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 189918014705 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 189918014706 Na binding site [ion binding]; other site 189918014707 putative substrate binding site [chemical binding]; other site 189918014708 Predicted transcriptional regulators [Transcription]; Region: COG1695 189918014709 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 189918014710 Predicted transcriptional regulators [Transcription]; Region: COG1695 189918014711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918014712 dimerization interface [polypeptide binding]; other site 189918014713 putative DNA binding site [nucleotide binding]; other site 189918014714 putative Zn2+ binding site [ion binding]; other site 189918014715 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918014716 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918014717 active site 189918014718 catalytic tetrad [active] 189918014719 glycerol kinase; Provisional; Region: glpK; PRK00047 189918014720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 189918014721 nucleotide binding site [chemical binding]; other site 189918014722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918014723 S-adenosylmethionine binding site [chemical binding]; other site 189918014724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918014725 metabolite-proton symporter; Region: 2A0106; TIGR00883 189918014726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918014727 S-adenosylmethionine binding site [chemical binding]; other site 189918014728 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 189918014729 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 189918014730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918014731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918014732 catalytic residue [active] 189918014733 catalytic residue [active] 189918014734 Uncharacterized conserved protein [Function unknown]; Region: COG4301 189918014735 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 189918014736 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 189918014737 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 189918014738 putative active site [active] 189918014739 putative dimer interface [polypeptide binding]; other site 189918014740 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 189918014741 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 189918014742 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 189918014743 PknH-like extracellular domain; Region: PknH_C; pfam14032 189918014744 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 189918014745 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189918014746 putative DNA binding helix; other site 189918014747 metal binding site 2 [ion binding]; metal-binding site 189918014748 metal binding site 1 [ion binding]; metal-binding site 189918014749 dimer interface [polypeptide binding]; other site 189918014750 structural Zn2+ binding site [ion binding]; other site 189918014751 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 189918014752 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 189918014753 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 189918014754 aspartate kinase; Reviewed; Region: PRK06635 189918014755 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 189918014756 putative nucleotide binding site [chemical binding]; other site 189918014757 putative catalytic residues [active] 189918014758 putative Mg ion binding site [ion binding]; other site 189918014759 putative aspartate binding site [chemical binding]; other site 189918014760 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 189918014761 putative allosteric regulatory site; other site 189918014762 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 189918014763 putative allosteric regulatory residue; other site 189918014764 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 189918014765 putative FMN binding site [chemical binding]; other site 189918014766 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 189918014767 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 189918014768 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189918014769 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918014770 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 189918014771 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 189918014772 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 189918014773 active site 189918014774 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 189918014775 domain_subunit interface; other site 189918014776 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189918014777 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 189918014778 active site 189918014779 FMN binding site [chemical binding]; other site 189918014780 substrate binding site [chemical binding]; other site 189918014781 3Fe-4S cluster binding site [ion binding]; other site 189918014782 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918014783 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 189918014784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189918014785 non-specific DNA binding site [nucleotide binding]; other site 189918014786 salt bridge; other site 189918014787 sequence-specific DNA binding site [nucleotide binding]; other site 189918014788 Cupin domain; Region: Cupin_2; pfam07883 189918014789 2-isopropylmalate synthase; Validated; Region: PRK03739 189918014790 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 189918014791 active site 189918014792 catalytic residues [active] 189918014793 metal binding site [ion binding]; metal-binding site 189918014794 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 189918014795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189918014796 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 189918014797 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 189918014798 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 189918014799 active site 189918014800 catalytic site [active] 189918014801 substrate binding site [chemical binding]; other site 189918014802 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 189918014803 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 189918014804 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 189918014805 catalytic triad [active] 189918014806 recombination protein RecR; Reviewed; Region: recR; PRK00076 189918014807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 189918014808 RecR protein; Region: RecR; pfam02132 189918014809 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 189918014810 putative active site [active] 189918014811 putative metal-binding site [ion binding]; other site 189918014812 tetramer interface [polypeptide binding]; other site 189918014813 hypothetical protein; Validated; Region: PRK00153 189918014814 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 189918014815 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 189918014816 active site 189918014817 metal binding site [ion binding]; metal-binding site 189918014818 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 189918014819 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189918014820 FAD binding domain; Region: FAD_binding_4; pfam01565 189918014821 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 189918014822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918014823 S-adenosylmethionine binding site [chemical binding]; other site 189918014824 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 189918014825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918014826 Walker A motif; other site 189918014827 ATP binding site [chemical binding]; other site 189918014828 Walker B motif; other site 189918014829 arginine finger; other site 189918014830 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 189918014831 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 189918014832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918014833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918014834 catalytic residue [active] 189918014835 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189918014836 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189918014837 protein binding site [polypeptide binding]; other site 189918014838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014839 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 189918014840 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189918014841 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 189918014842 nucleotide binding site [chemical binding]; other site 189918014843 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 189918014844 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 189918014845 active site 189918014846 DNA binding site [nucleotide binding] 189918014847 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 189918014848 DNA binding site [nucleotide binding] 189918014849 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918014850 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918014851 active site 189918014852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014854 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918014855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918014856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014857 NAD(P) binding site [chemical binding]; other site 189918014858 active site 189918014859 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 189918014860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918014861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918014862 DNA binding residues [nucleotide binding] 189918014863 AAA ATPase domain; Region: AAA_16; pfam13191 189918014864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189918014865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189918014866 DNA binding residues [nucleotide binding] 189918014867 dimerization interface [polypeptide binding]; other site 189918014868 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 189918014869 putative FMN binding site [chemical binding]; other site 189918014870 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 189918014871 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918014872 classical (c) SDRs; Region: SDR_c; cd05233 189918014873 NAD(P) binding site [chemical binding]; other site 189918014874 active site 189918014875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918014876 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014877 Cytochrome P450; Region: p450; cl12078 189918014878 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 189918014879 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918014880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918014881 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918014882 active site 189918014883 metal binding site [ion binding]; metal-binding site 189918014884 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 189918014885 classical (c) SDRs; Region: SDR_c; cd05233 189918014886 NAD(P) binding site [chemical binding]; other site 189918014887 active site 189918014888 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 189918014889 FMN binding site [chemical binding]; other site 189918014890 dimer interface [polypeptide binding]; other site 189918014891 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 189918014892 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918014893 short chain dehydrogenase; Provisional; Region: PRK08303 189918014894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014895 NAD(P) binding site [chemical binding]; other site 189918014896 active site 189918014897 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014898 Cytochrome P450; Region: p450; cl12078 189918014899 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918014900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918014901 NAD(P) binding site [chemical binding]; other site 189918014902 active site 189918014903 choline dehydrogenase; Validated; Region: PRK02106 189918014904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918014905 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189918014906 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 189918014907 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 189918014908 active site 189918014909 DNA binding site [nucleotide binding] 189918014910 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 189918014911 DNA binding site [nucleotide binding] 189918014912 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 189918014913 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 189918014914 homodimer interface [polypeptide binding]; other site 189918014915 putative substrate binding pocket [chemical binding]; other site 189918014916 diiron center [ion binding]; other site 189918014917 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 189918014918 active site 189918014919 HIGH motif; other site 189918014920 nucleotide binding site [chemical binding]; other site 189918014921 active site 189918014922 KMSKS motif; other site 189918014923 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918014924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918014925 substrate binding pocket [chemical binding]; other site 189918014926 membrane-bound complex binding site; other site 189918014927 hinge residues; other site 189918014928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 189918014929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918014930 dimer interface [polypeptide binding]; other site 189918014931 conserved gate region; other site 189918014932 putative PBP binding loops; other site 189918014933 ABC-ATPase subunit interface; other site 189918014934 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 189918014935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918014936 Walker A/P-loop; other site 189918014937 ATP binding site [chemical binding]; other site 189918014938 Q-loop/lid; other site 189918014939 ABC transporter signature motif; other site 189918014940 Walker B; other site 189918014941 D-loop; other site 189918014942 H-loop/switch region; other site 189918014943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918014944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918014945 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 189918014946 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 189918014947 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918014948 Cytochrome P450; Region: p450; cl12078 189918014949 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 189918014950 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 189918014951 haloalkane dehalogenase; Provisional; Region: PRK00870 189918014952 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 189918014953 PE-PPE domain; Region: PE-PPE; pfam08237 189918014954 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 189918014955 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 189918014956 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 189918014957 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 189918014958 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 189918014959 alpha-beta subunit interface [polypeptide binding]; other site 189918014960 alpha-gamma subunit interface [polypeptide binding]; other site 189918014961 active site 189918014962 substrate and K+ binding site; other site 189918014963 K+ binding site [ion binding]; other site 189918014964 cobalamin binding site [chemical binding]; other site 189918014965 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 189918014966 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 189918014967 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189918014968 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 189918014969 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 189918014970 active site 189918014971 Zn binding site [ion binding]; other site 189918014972 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 189918014973 prephenate dehydrogenase; Validated; Region: PRK06545 189918014974 prephenate dehydrogenase; Validated; Region: PRK08507 189918014975 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 189918014976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918014977 dimer interface [polypeptide binding]; other site 189918014978 ABC-ATPase subunit interface; other site 189918014979 putative PBP binding loops; other site 189918014980 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 189918014981 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918014982 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 189918014983 Walker A/P-loop; other site 189918014984 ATP binding site [chemical binding]; other site 189918014985 Q-loop/lid; other site 189918014986 ABC transporter signature motif; other site 189918014987 Walker B; other site 189918014988 D-loop; other site 189918014989 H-loop/switch region; other site 189918014990 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 189918014991 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 189918014992 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189918014993 putative active site [active] 189918014994 putative substrate binding site [chemical binding]; other site 189918014995 ATP binding site [chemical binding]; other site 189918014996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918014997 catalytic core [active] 189918014998 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 189918014999 classical (c) SDRs; Region: SDR_c; cd05233 189918015000 NAD(P) binding site [chemical binding]; other site 189918015001 active site 189918015002 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 189918015003 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189918015004 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 189918015005 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918015006 Predicted transcriptional regulators [Transcription]; Region: COG1733 189918015007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918015008 dimerization interface [polypeptide binding]; other site 189918015009 putative Zn2+ binding site [ion binding]; other site 189918015010 putative DNA binding site [nucleotide binding]; other site 189918015011 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 189918015012 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 189918015013 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 189918015014 Protein of unknown function (DUF419); Region: DUF419; cl15265 189918015015 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 189918015016 active site 189918015017 metal binding site [ion binding]; metal-binding site 189918015018 homotetramer interface [polypeptide binding]; other site 189918015019 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 189918015020 Cutinase; Region: Cutinase; pfam01083 189918015021 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918015022 Ligand Binding Site [chemical binding]; other site 189918015023 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189918015024 Ligand Binding Site [chemical binding]; other site 189918015025 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 189918015026 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918015027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918015028 homodimer interface [polypeptide binding]; other site 189918015029 catalytic residue [active] 189918015030 GXWXG protein; Region: GXWXG; pfam14231 189918015031 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 189918015032 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 189918015033 TIGR03086 family protein; Region: TIGR03086 189918015034 enoyl-CoA hydratase; Provisional; Region: PRK06142 189918015035 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189918015036 substrate binding site [chemical binding]; other site 189918015037 oxyanion hole (OAH) forming residues; other site 189918015038 trimer interface [polypeptide binding]; other site 189918015039 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918015040 MarR family; Region: MarR; pfam01047 189918015041 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 189918015042 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 189918015043 NAD(P) binding site [chemical binding]; other site 189918015044 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 189918015045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918015046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918015047 catalytic residue [active] 189918015048 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 189918015049 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 189918015050 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 189918015051 Walker A/P-loop; other site 189918015052 ATP binding site [chemical binding]; other site 189918015053 Q-loop/lid; other site 189918015054 ABC transporter signature motif; other site 189918015055 Walker B; other site 189918015056 D-loop; other site 189918015057 H-loop/switch region; other site 189918015058 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 189918015059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918015060 active site 189918015061 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 189918015062 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 189918015063 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 189918015064 Phosphotransferase enzyme family; Region: APH; pfam01636 189918015065 Uncharacterized conserved protein [Function unknown]; Region: COG2128 189918015066 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 189918015067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918015068 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 189918015069 DNA-binding site [nucleotide binding]; DNA binding site 189918015070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189918015071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918015072 homodimer interface [polypeptide binding]; other site 189918015073 catalytic residue [active] 189918015074 Predicted membrane protein [Function unknown]; Region: COG2246 189918015075 GtrA-like protein; Region: GtrA; pfam04138 189918015076 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189918015077 FAD binding domain; Region: FAD_binding_4; pfam01565 189918015078 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 189918015079 short chain dehydrogenase; Provisional; Region: PRK07904 189918015080 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189918015081 NAD(P) binding site [chemical binding]; other site 189918015082 active site 189918015083 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 189918015084 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 189918015085 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 189918015086 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 189918015087 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 189918015088 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918015089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918015090 active site 189918015091 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918015092 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918015093 active site 189918015094 ATP binding site [chemical binding]; other site 189918015095 substrate binding site [chemical binding]; other site 189918015096 activation loop (A-loop); other site 189918015097 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189918015098 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 189918015099 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 189918015100 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918015101 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 189918015102 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 189918015103 active site 189918015104 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 189918015105 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 189918015106 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 189918015107 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 189918015108 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 189918015109 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918015110 acyl-activating enzyme (AAE) consensus motif; other site 189918015111 active site 189918015112 Cutinase; Region: Cutinase; pfam01083 189918015113 Putative esterase; Region: Esterase; pfam00756 189918015114 Putative esterase; Region: Esterase; pfam00756 189918015115 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 189918015116 UbiA prenyltransferase family; Region: UbiA; pfam01040 189918015117 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 189918015118 active site 189918015119 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 189918015120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189918015121 active site 189918015122 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 189918015123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918015124 UDP-galactopyranose mutase; Region: GLF; pfam03275 189918015125 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 189918015126 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 189918015127 amidase catalytic site [active] 189918015128 Zn binding residues [ion binding]; other site 189918015129 substrate binding site [chemical binding]; other site 189918015130 LGFP repeat; Region: LGFP; pfam08310 189918015131 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 189918015132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918015133 active site 189918015134 motif I; other site 189918015135 motif II; other site 189918015136 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 189918015137 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918015138 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189918015139 putative acyl-acceptor binding pocket; other site 189918015140 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918015141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189918015142 putative acyl-acceptor binding pocket; other site 189918015143 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 189918015144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918015145 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918015146 iron-sulfur cluster [ion binding]; other site 189918015147 [2Fe-2S] cluster binding site [ion binding]; other site 189918015148 seryl-tRNA synthetase; Provisional; Region: PRK05431 189918015149 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 189918015150 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 189918015151 dimer interface [polypeptide binding]; other site 189918015152 active site 189918015153 motif 1; other site 189918015154 motif 2; other site 189918015155 motif 3; other site 189918015156 Septum formation; Region: Septum_form; pfam13845 189918015157 Septum formation; Region: Septum_form; pfam13845 189918015158 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 189918015159 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918015160 catalytic core [active] 189918015161 prephenate dehydratase; Provisional; Region: PRK11898 189918015162 Prephenate dehydratase; Region: PDT; pfam00800 189918015163 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 189918015164 putative L-Phe binding site [chemical binding]; other site 189918015165 CAAX protease self-immunity; Region: Abi; pfam02517 189918015166 Transcriptional regulator [Transcription]; Region: LytR; COG1316 189918015167 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 189918015168 Ferritin-like domain; Region: Ferritin; pfam00210 189918015169 ferroxidase diiron center [ion binding]; other site 189918015170 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 189918015171 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 189918015172 putative active site [active] 189918015173 catalytic site [active] 189918015174 putative metal binding site [ion binding]; other site 189918015175 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 189918015176 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918015177 active site residue [active] 189918015178 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 189918015179 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 189918015180 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 189918015181 yybP-ykoY element as predicted by Rfam (RF00080), score 60.05 189918015182 Predicted membrane protein [Function unknown]; Region: COG2119 189918015183 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 189918015184 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 189918015185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 189918015186 CopC domain; Region: CopC; pfam04234 189918015187 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 189918015188 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918015189 DNA binding residues [nucleotide binding] 189918015190 dimer interface [polypeptide binding]; other site 189918015191 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 189918015192 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 189918015193 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918015194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918015195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015197 DNA polymerase IV; Validated; Region: PRK03858 189918015198 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 189918015199 active site 189918015200 DNA binding site [nucleotide binding] 189918015201 hydroperoxidase II; Provisional; Region: katE; PRK11249 189918015202 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 189918015203 heme binding pocket [chemical binding]; other site 189918015204 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 189918015205 domain interactions; other site 189918015206 hypothetical protein; Provisional; Region: PRK07945 189918015207 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 189918015208 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 189918015209 active site 189918015210 TIGR03086 family protein; Region: TIGR03086 189918015211 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 189918015212 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918015213 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 189918015214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918015215 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 189918015216 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 189918015217 active site 189918015218 dimer interface [polypeptide binding]; other site 189918015219 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 189918015220 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189918015221 active site 189918015222 FMN binding site [chemical binding]; other site 189918015223 substrate binding site [chemical binding]; other site 189918015224 3Fe-4S cluster binding site [ion binding]; other site 189918015225 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 189918015226 domain interface; other site 189918015227 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918015228 CoenzymeA binding site [chemical binding]; other site 189918015229 subunit interaction site [polypeptide binding]; other site 189918015230 PHB binding site; other site 189918015231 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 189918015232 amphipathic channel; other site 189918015233 Asn-Pro-Ala signature motifs; other site 189918015234 Protein of unknown function (DUF732); Region: DUF732; pfam05305 189918015235 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 189918015236 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 189918015237 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 189918015238 dimerization interface [polypeptide binding]; other site 189918015239 DPS ferroxidase diiron center [ion binding]; other site 189918015240 ion pore; other site 189918015241 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 189918015242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189918015243 minor groove reading motif; other site 189918015244 helix-hairpin-helix signature motif; other site 189918015245 active site 189918015246 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189918015247 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 189918015248 substrate binding pocket [chemical binding]; other site 189918015249 chain length determination region; other site 189918015250 substrate-Mg2+ binding site; other site 189918015251 catalytic residues [active] 189918015252 aspartate-rich region 1; other site 189918015253 active site lid residues [active] 189918015254 aspartate-rich region 2; other site 189918015255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918015256 phytoene desaturase; Region: crtI_fam; TIGR02734 189918015257 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 189918015258 active site lid residues [active] 189918015259 substrate binding pocket [chemical binding]; other site 189918015260 catalytic residues [active] 189918015261 substrate-Mg2+ binding site; other site 189918015262 aspartate-rich region 1; other site 189918015263 aspartate-rich region 2; other site 189918015264 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 189918015265 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 189918015266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189918015267 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 189918015268 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 189918015269 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 189918015270 iron-sulfur cluster [ion binding]; other site 189918015271 [2Fe-2S] cluster binding site [ion binding]; other site 189918015272 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 189918015273 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 189918015274 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 189918015275 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 189918015276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 189918015277 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189918015278 hydrophobic ligand binding site; other site 189918015279 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 189918015280 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918015281 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 189918015282 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918015283 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 189918015284 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 189918015285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918015286 NAD(P) binding site [chemical binding]; other site 189918015287 active site 189918015288 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918015289 SelR domain; Region: SelR; pfam01641 189918015290 methionine sulfoxide reductase B; Provisional; Region: PRK00222 189918015291 methionine sulfoxide reductase A; Provisional; Region: PRK14054 189918015292 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918015293 Cytochrome P450; Region: p450; cl12078 189918015294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015296 Methyltransferase domain; Region: Methyltransf_24; pfam13578 189918015297 FOG: CBS domain [General function prediction only]; Region: COG0517 189918015298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 189918015299 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 189918015300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918015301 dimerization interface [polypeptide binding]; other site 189918015302 putative Zn2+ binding site [ion binding]; other site 189918015303 putative DNA binding site [nucleotide binding]; other site 189918015304 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 189918015305 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 189918015306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189918015307 S-adenosylmethionine binding site [chemical binding]; other site 189918015308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189918015309 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 189918015310 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 189918015311 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918015312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918015314 active site 189918015315 Domain of unknown function (DUF427); Region: DUF427; cl00998 189918015316 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 189918015317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189918015318 NAD binding site [chemical binding]; other site 189918015319 catalytic Zn binding site [ion binding]; other site 189918015320 structural Zn binding site [ion binding]; other site 189918015321 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918015322 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 189918015323 Isochorismatase family; Region: Isochorismatase; pfam00857 189918015324 catalytic triad [active] 189918015325 metal binding site [ion binding]; metal-binding site 189918015326 conserved cis-peptide bond; other site 189918015327 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 189918015328 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 189918015329 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 189918015330 active site 189918015331 catalytic site [active] 189918015332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015334 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 189918015335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918015336 active site 189918015337 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 189918015338 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918015339 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918015340 active site 189918015341 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 189918015342 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 189918015343 trehalose synthase; Region: treS_nterm; TIGR02456 189918015344 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 189918015345 active site 189918015346 catalytic site [active] 189918015347 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 189918015348 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 189918015349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918015350 active site 189918015351 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 189918015352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189918015353 Walker A/P-loop; other site 189918015354 ATP binding site [chemical binding]; other site 189918015355 Q-loop/lid; other site 189918015356 ABC transporter signature motif; other site 189918015357 Walker B; other site 189918015358 D-loop; other site 189918015359 H-loop/switch region; other site 189918015360 TOBE domain; Region: TOBE_2; pfam08402 189918015361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918015362 dimer interface [polypeptide binding]; other site 189918015363 conserved gate region; other site 189918015364 putative PBP binding loops; other site 189918015365 ABC-ATPase subunit interface; other site 189918015366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 189918015367 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 189918015368 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 189918015369 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 189918015370 Cupin domain; Region: Cupin_2; cl17218 189918015371 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 189918015372 putative hydrophobic ligand binding site [chemical binding]; other site 189918015373 protein interface [polypeptide binding]; other site 189918015374 gate; other site 189918015375 dihydroxyacetone kinase; Provisional; Region: PRK14479 189918015376 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 189918015377 DAK2 domain; Region: Dak2; pfam02734 189918015378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015380 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 189918015381 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 189918015382 elongation factor G; Reviewed; Region: PRK12740 189918015383 G1 box; other site 189918015384 putative GEF interaction site [polypeptide binding]; other site 189918015385 GTP/Mg2+ binding site [chemical binding]; other site 189918015386 Switch I region; other site 189918015387 G2 box; other site 189918015388 G3 box; other site 189918015389 Switch II region; other site 189918015390 G4 box; other site 189918015391 G5 box; other site 189918015392 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 189918015393 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 189918015394 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 189918015395 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 189918015396 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 189918015397 mce related protein; Region: MCE; pfam02470 189918015398 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 189918015399 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189918015400 catalytic core [active] 189918015401 MMPL family; Region: MMPL; pfam03176 189918015402 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189918015403 Rhomboid family; Region: Rhomboid; pfam01694 189918015404 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918015405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918015406 active site 189918015407 amidase; Validated; Region: PRK06565 189918015408 Amidase; Region: Amidase; cl11426 189918015409 Cupin; Region: Cupin_6; pfam12852 189918015410 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 189918015411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189918015412 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 189918015413 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 189918015414 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 189918015415 Cytochrome P450; Region: p450; cl12078 189918015416 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 189918015417 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189918015418 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 189918015419 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918015420 anti sigma factor interaction site; other site 189918015421 regulatory phosphorylation site [posttranslational modification]; other site 189918015422 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189918015423 B12 binding domain; Region: B12-binding_2; pfam02607 189918015424 B12 binding domain; Region: B12-binding; pfam02310 189918015425 B12 binding site [chemical binding]; other site 189918015426 von Willebrand factor type A domain; Region: VWA_2; pfam13519 189918015427 Protein of unknown function DUF58; Region: DUF58; pfam01882 189918015428 MoxR-like ATPases [General function prediction only]; Region: COG0714 189918015429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189918015430 Walker A motif; other site 189918015431 ATP binding site [chemical binding]; other site 189918015432 Walker B motif; other site 189918015433 arginine finger; other site 189918015434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918015437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015439 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 189918015440 putative hydrophobic ligand binding site [chemical binding]; other site 189918015441 short chain dehydrogenase; Provisional; Region: PRK06197 189918015442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918015443 NAD(P) binding site [chemical binding]; other site 189918015444 active site 189918015445 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 189918015446 active site 189918015447 catalytic triad [active] 189918015448 oxyanion hole [active] 189918015449 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 189918015450 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 189918015451 amino acid transporter; Region: 2A0306; TIGR00909 189918015452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918015453 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918015454 active site 189918015455 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918015456 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918015457 PAS fold; Region: PAS_3; pfam08447 189918015458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189918015459 putative active site [active] 189918015460 heme pocket [chemical binding]; other site 189918015461 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918015462 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189918015463 anti sigma factor interaction site; other site 189918015464 regulatory phosphorylation site [posttranslational modification]; other site 189918015465 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918015466 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 189918015467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918015469 active site 189918015470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015471 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918015472 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918015473 active site 189918015474 hypothetical protein; Validated; Region: PRK07198 189918015475 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 189918015476 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 189918015477 dimerization interface [polypeptide binding]; other site 189918015478 active site 189918015479 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 189918015480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189918015481 active site 189918015482 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 189918015483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918015484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918015485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918015486 active site 189918015487 metal binding site [ion binding]; metal-binding site 189918015488 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 189918015489 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 189918015490 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 189918015491 FAD binding domain; Region: FAD_binding_2; pfam00890 189918015492 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 189918015493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 189918015494 Uncharacterized conserved protein [Function unknown]; Region: COG0397 189918015495 hypothetical protein; Validated; Region: PRK00029 189918015496 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 189918015497 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 189918015498 homodimer interface [polypeptide binding]; other site 189918015499 homotetramer interface [polypeptide binding]; other site 189918015500 active site pocket [active] 189918015501 cleavage site 189918015502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918015505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918015506 metal binding site [ion binding]; metal-binding site 189918015507 active site 189918015508 I-site; other site 189918015509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918015511 active site 189918015512 short chain dehydrogenase; Provisional; Region: PRK05872 189918015513 classical (c) SDRs; Region: SDR_c; cd05233 189918015514 NAD(P) binding site [chemical binding]; other site 189918015515 active site 189918015516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189918015517 active site 189918015518 metal binding site [ion binding]; metal-binding site 189918015519 selenophosphate synthetase; Provisional; Region: PRK00943 189918015520 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 189918015521 dimerization interface [polypeptide binding]; other site 189918015522 putative ATP binding site [chemical binding]; other site 189918015523 selenocysteine synthase; Provisional; Region: PRK04311 189918015524 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 189918015525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 189918015526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189918015527 catalytic residue [active] 189918015528 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 189918015529 G1 box; other site 189918015530 putative GEF interaction site [polypeptide binding]; other site 189918015531 GTP/Mg2+ binding site [chemical binding]; other site 189918015532 Switch I region; other site 189918015533 G2 box; other site 189918015534 G3 box; other site 189918015535 Switch II region; other site 189918015536 G4 box; other site 189918015537 G5 box; other site 189918015538 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 189918015539 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 189918015540 Transcriptional regulator PadR-like family; Region: PadR; cl17335 189918015541 Predicted transcriptional regulators [Transcription]; Region: COG1695 189918015542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918015543 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918015544 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918015545 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189918015546 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 189918015547 molybdopterin cofactor binding site; other site 189918015548 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 189918015549 4Fe-4S binding domain; Region: Fer4_6; pfam12837 189918015550 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 189918015551 Cutinase; Region: Cutinase; pfam01083 189918015552 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189918015553 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 189918015554 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 189918015555 Uncharacterized conserved protein [Function unknown]; Region: COG0398 189918015556 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 189918015557 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 189918015558 nucleotide binding site [chemical binding]; other site 189918015559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 189918015560 SnoaL-like domain; Region: SnoaL_2; pfam12680 189918015561 short chain dehydrogenase; Provisional; Region: PRK06940 189918015562 classical (c) SDRs; Region: SDR_c; cd05233 189918015563 NAD(P) binding site [chemical binding]; other site 189918015564 active site 189918015565 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 189918015566 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 189918015567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015569 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 189918015570 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918015571 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 189918015572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189918015573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918015574 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 189918015575 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 189918015576 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 189918015577 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 189918015578 acyl-activating enzyme (AAE) consensus motif; other site 189918015579 active site 189918015580 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918015581 GAF domain; Region: GAF_3; pfam13492 189918015582 ANTAR domain; Region: ANTAR; pfam03861 189918015583 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 189918015584 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 189918015585 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 189918015586 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 189918015587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015589 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 189918015590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918015591 putative substrate translocation pore; other site 189918015592 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189918015593 MarR family; Region: MarR_2; pfam12802 189918015594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918015595 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189918015596 NAD(P) binding site [chemical binding]; other site 189918015597 active site 189918015598 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918015599 MarR family; Region: MarR_2; cl17246 189918015600 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 189918015601 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918015602 putative active site [active] 189918015603 putative metal binding site [ion binding]; other site 189918015604 Cupin superfamily protein; Region: Cupin_4; pfam08007 189918015605 Cupin-like domain; Region: Cupin_8; pfam13621 189918015606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189918015607 Domain of unknown function DUF302; Region: DUF302; cl01364 189918015608 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189918015609 CoenzymeA binding site [chemical binding]; other site 189918015610 subunit interaction site [polypeptide binding]; other site 189918015611 PHB binding site; other site 189918015612 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 189918015613 NmrA-like family; Region: NmrA; pfam05368 189918015614 putative NADP binding site [chemical binding]; other site 189918015615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015617 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 189918015618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189918015619 putative substrate translocation pore; other site 189918015620 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 189918015621 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 189918015622 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 189918015623 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 189918015624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189918015625 ATP binding site [chemical binding]; other site 189918015626 putative Mg++ binding site [ion binding]; other site 189918015627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189918015628 nucleotide binding region [chemical binding]; other site 189918015629 ATP-binding site [chemical binding]; other site 189918015630 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 189918015631 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 189918015632 putative active site [active] 189918015633 putative CoA binding site [chemical binding]; other site 189918015634 nudix motif; other site 189918015635 metal binding site [ion binding]; metal-binding site 189918015636 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 189918015637 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 189918015638 tetramer interface [polypeptide binding]; other site 189918015639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189918015640 catalytic residue [active] 189918015641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918015642 dimerization interface [polypeptide binding]; other site 189918015643 putative DNA binding site [nucleotide binding]; other site 189918015644 putative Zn2+ binding site [ion binding]; other site 189918015645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 189918015646 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 189918015647 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 189918015648 Part of AAA domain; Region: AAA_19; pfam13245 189918015649 Family description; Region: UvrD_C_2; pfam13538 189918015650 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 189918015651 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189918015652 active site 189918015653 FMN binding site [chemical binding]; other site 189918015654 substrate binding site [chemical binding]; other site 189918015655 3Fe-4S cluster binding site [ion binding]; other site 189918015656 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 189918015657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 189918015658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189918015659 metal binding site [ion binding]; metal-binding site 189918015660 active site 189918015661 I-site; other site 189918015662 hypothetical protein; Provisional; Region: PRK06547 189918015663 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 189918015664 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918015665 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918015666 Walker A/P-loop; other site 189918015667 ATP binding site [chemical binding]; other site 189918015668 Q-loop/lid; other site 189918015669 ABC transporter signature motif; other site 189918015670 Walker B; other site 189918015671 D-loop; other site 189918015672 H-loop/switch region; other site 189918015673 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918015674 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 189918015675 Walker A/P-loop; other site 189918015676 ATP binding site [chemical binding]; other site 189918015677 Q-loop/lid; other site 189918015678 ABC transporter signature motif; other site 189918015679 Walker B; other site 189918015680 D-loop; other site 189918015681 H-loop/switch region; other site 189918015682 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 189918015683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015684 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 189918015685 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189918015686 active site 189918015687 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189918015688 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189918015689 active site 189918015690 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918015691 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918015692 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189918015693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 189918015694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 189918015695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 189918015696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 189918015697 dimerization interface [polypeptide binding]; other site 189918015698 Cobalt transport protein; Region: CbiQ; cl00463 189918015699 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 189918015700 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 189918015701 Walker A/P-loop; other site 189918015702 ATP binding site [chemical binding]; other site 189918015703 Q-loop/lid; other site 189918015704 ABC transporter signature motif; other site 189918015705 Walker B; other site 189918015706 D-loop; other site 189918015707 H-loop/switch region; other site 189918015708 BioY family; Region: BioY; pfam02632 189918015709 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 189918015710 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 189918015711 active site 189918015712 catalytic site [active] 189918015713 Zn binding site [ion binding]; other site 189918015714 tetramer interface [polypeptide binding]; other site 189918015715 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 189918015716 agmatinase; Region: agmatinase; TIGR01230 189918015717 oligomer interface [polypeptide binding]; other site 189918015718 putative active site [active] 189918015719 Mn binding site [ion binding]; other site 189918015720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 189918015721 classical (c) SDRs; Region: SDR_c; cd05233 189918015722 NAD(P) binding site [chemical binding]; other site 189918015723 active site 189918015724 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189918015725 classical (c) SDRs; Region: SDR_c; cd05233 189918015726 NAD(P) binding site [chemical binding]; other site 189918015727 active site 189918015728 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 189918015729 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 189918015730 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 189918015731 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 189918015732 Ferredoxin [Energy production and conversion]; Region: COG1146 189918015733 4Fe-4S binding domain; Region: Fer4; pfam00037 189918015734 Predicted transcriptional regulator [Transcription]; Region: COG2345 189918015735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189918015736 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 189918015737 heme-binding site [chemical binding]; other site 189918015738 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 189918015739 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 189918015740 Amidase; Region: Amidase; cl11426 189918015741 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 189918015742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918015743 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 189918015744 YCII-related domain; Region: YCII; cl00999 189918015745 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 189918015746 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 189918015747 putative active site [active] 189918015748 putative FMN binding site [chemical binding]; other site 189918015749 putative substrate binding site [chemical binding]; other site 189918015750 putative catalytic residue [active] 189918015751 FAD binding domain; Region: FAD_binding_3; pfam01494 189918015752 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918015753 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189918015754 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918015755 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918015756 ABC transporter; Region: ABC_tran_2; pfam12848 189918015757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189918015758 Cutinase; Region: Cutinase; pfam01083 189918015759 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 189918015760 Pirin-related protein [General function prediction only]; Region: COG1741 189918015761 Pirin; Region: Pirin; pfam02678 189918015762 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 189918015763 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 189918015764 classical (c) SDRs; Region: SDR_c; cd05233 189918015765 NAD(P) binding site [chemical binding]; other site 189918015766 active site 189918015767 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 189918015768 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 189918015769 MOSC domain; Region: MOSC; pfam03473 189918015770 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918015771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918015774 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 189918015775 active site 189918015776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189918015777 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189918015778 catalytic residues [active] 189918015779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 189918015780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918015781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918015782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189918015783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189918015784 active site residue [active] 189918015785 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918015786 active site residue [active] 189918015787 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189918015788 active site residue [active] 189918015789 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 189918015790 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 189918015791 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 189918015792 putative homodimer interface [polypeptide binding]; other site 189918015793 putative homotetramer interface [polypeptide binding]; other site 189918015794 putative allosteric switch controlling residues; other site 189918015795 putative metal binding site [ion binding]; other site 189918015796 putative homodimer-homodimer interface [polypeptide binding]; other site 189918015797 Predicted membrane protein [Function unknown]; Region: COG2149 189918015798 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 189918015799 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189918015800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189918015801 motif II; other site 189918015802 Domain of unknown function (DUF305); Region: DUF305; pfam03713 189918015803 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 189918015804 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 189918015805 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 189918015806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189918015807 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 189918015808 active site 189918015809 catalytic tetrad [active] 189918015810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189918015811 MarR family; Region: MarR_2; pfam12802 189918015812 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189918015813 active site 189918015814 catalytic site [active] 189918015815 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 189918015816 active site 189918015817 catalytic site [active] 189918015818 EVE domain; Region: EVE; cl00728 189918015819 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 189918015820 Transcriptional regulators [Transcription]; Region: FadR; COG2186 189918015821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918015822 DNA-binding site [nucleotide binding]; DNA binding site 189918015823 FCD domain; Region: FCD; pfam07729 189918015824 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 189918015825 AAA domain; Region: AAA_33; pfam13671 189918015826 ATP-binding site [chemical binding]; other site 189918015827 Gluconate-6-phosphate binding site [chemical binding]; other site 189918015828 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 189918015829 fructuronate transporter; Provisional; Region: PRK10034; cl15264 189918015830 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 189918015831 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 189918015832 active site 189918015833 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189918015834 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 189918015835 putative NAD(P) binding site [chemical binding]; other site 189918015836 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 189918015837 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 189918015838 dimer interface [polypeptide binding]; other site 189918015839 acyl-activating enzyme (AAE) consensus motif; other site 189918015840 putative active site [active] 189918015841 AMP binding site [chemical binding]; other site 189918015842 putative CoA binding site [chemical binding]; other site 189918015843 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 189918015844 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189918015845 active site 189918015846 FMN binding site [chemical binding]; other site 189918015847 substrate binding site [chemical binding]; other site 189918015848 3Fe-4S cluster binding site [ion binding]; other site 189918015849 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 189918015850 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 189918015851 nucleophilic elbow; other site 189918015852 catalytic triad; other site 189918015853 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 189918015854 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189918015855 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 189918015856 putative acyl-acceptor binding pocket; other site 189918015857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015859 short chain dehydrogenase; Provisional; Region: PRK06523 189918015860 classical (c) SDRs; Region: SDR_c; cd05233 189918015861 NAD(P) binding site [chemical binding]; other site 189918015862 active site 189918015863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189918015864 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 189918015865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 189918015866 DNA binding residues [nucleotide binding] 189918015867 dimer interface [polypeptide binding]; other site 189918015868 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 189918015869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189918015870 Mg2+ binding site [ion binding]; other site 189918015871 G-X-G motif; other site 189918015872 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 189918015873 ATP binding site [chemical binding]; other site 189918015874 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 189918015875 active site 189918015876 metal binding site [ion binding]; metal-binding site 189918015877 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 189918015878 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 189918015879 CAP-like domain; other site 189918015880 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 189918015881 active site 189918015882 primary dimer interface [polypeptide binding]; other site 189918015883 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189918015884 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 189918015885 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189918015886 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 189918015887 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 189918015888 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 189918015889 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 189918015890 NAD binding site [chemical binding]; other site 189918015891 ligand binding site [chemical binding]; other site 189918015892 catalytic site [active] 189918015893 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189918015894 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 189918015895 hypothetical protein; Provisional; Region: PRK06847 189918015896 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 189918015897 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 189918015898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918015899 dimer interface [polypeptide binding]; other site 189918015900 conserved gate region; other site 189918015901 putative PBP binding loops; other site 189918015902 ABC-ATPase subunit interface; other site 189918015903 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 189918015904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 189918015905 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 189918015906 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 189918015907 Walker A/P-loop; other site 189918015908 ATP binding site [chemical binding]; other site 189918015909 Q-loop/lid; other site 189918015910 ABC transporter signature motif; other site 189918015911 Walker B; other site 189918015912 D-loop; other site 189918015913 H-loop/switch region; other site 189918015914 NMT1-like family; Region: NMT1_2; pfam13379 189918015915 NMT1/THI5 like; Region: NMT1; pfam09084 189918015916 membrane-bound complex binding site; other site 189918015917 hinge residues; other site 189918015918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189918015919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189918015920 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 189918015921 active site 189918015922 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 189918015923 putative hydrophobic ligand binding site [chemical binding]; other site 189918015924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189918015925 dimerization interface [polypeptide binding]; other site 189918015926 putative DNA binding site [nucleotide binding]; other site 189918015927 putative Zn2+ binding site [ion binding]; other site 189918015928 Transposase, Mutator family; Region: Transposase_mut; pfam00872 189918015929 MULE transposase domain; Region: MULE; pfam10551 189918015930 Beta-lactamase; Region: Beta-lactamase; pfam00144 189918015931 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189918015932 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 189918015933 Domain of unknown function (DUF222); Region: DUF222; pfam02720 189918015934 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189918015935 active site 189918015936 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 189918015937 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189918015938 Walker A motif; other site 189918015939 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 189918015940 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 189918015941 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 189918015942 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 189918015943 Walker A motif; other site 189918015944 ATP binding site [chemical binding]; other site 189918015945 Walker B motif; other site 189918015946 DNA binding loops [nucleotide binding] 189918015947 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 189918015948 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 189918015949 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 189918015950 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 189918015951 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 189918015952 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 189918015953 dimer interface [polypeptide binding]; other site 189918015954 ssDNA binding site [nucleotide binding]; other site 189918015955 tetramer (dimer of dimers) interface [polypeptide binding]; other site 189918015956 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 189918015957 Predicted integral membrane protein [Function unknown]; Region: COG5650 189918015958 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 189918015959 Transglycosylase; Region: Transgly; pfam00912 189918015960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189918015961 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 189918015962 Predicted transcriptional regulators [Transcription]; Region: COG1695 189918015963 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 189918015964 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 189918015965 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 189918015966 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189918015967 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189918015968 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 189918015969 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 189918015970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 189918015971 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 189918015972 Transcriptional regulators [Transcription]; Region: GntR; COG1802 189918015973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 189918015974 DNA-binding site [nucleotide binding]; DNA binding site 189918015975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189918015976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189918015977 substrate binding pocket [chemical binding]; other site 189918015978 membrane-bound complex binding site; other site 189918015979 hinge residues; other site 189918015980 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 189918015981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189918015982 dimer interface [polypeptide binding]; other site 189918015983 conserved gate region; other site 189918015984 putative PBP binding loops; other site 189918015985 ABC-ATPase subunit interface; other site 189918015986 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 189918015987 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 189918015988 Walker A/P-loop; other site 189918015989 ATP binding site [chemical binding]; other site 189918015990 Q-loop/lid; other site 189918015991 ABC transporter signature motif; other site 189918015992 Walker B; other site 189918015993 D-loop; other site 189918015994 H-loop/switch region; other site 189918015995 MarR family; Region: MarR; pfam01047 189918015996 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 189918015997 short chain dehydrogenase; Provisional; Region: PRK08219 189918015998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189918015999 NAD(P) binding site [chemical binding]; other site 189918016000 active site 189918016001 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 189918016002 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 189918016003 putative active site [active] 189918016004 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 189918016005 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 189918016006 HIGH motif; other site 189918016007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 189918016008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 189918016009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 189918016010 active site 189918016011 KMSKS motif; other site 189918016012 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 189918016013 tRNA binding surface [nucleotide binding]; other site 189918016014 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 189918016015 hypothetical protein; Validated; Region: PRK00228 189918016016 H+ Antiporter protein; Region: 2A0121; TIGR00900 189918016017 TIGR03084 family protein; Region: TIGR03084 189918016018 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 189918016019 Wyosine base formation; Region: Wyosine_form; pfam08608 189918016020 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189918016021 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189918016022 active site 189918016023 ATP binding site [chemical binding]; other site 189918016024 substrate binding site [chemical binding]; other site 189918016025 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189918016026 substrate binding site [chemical binding]; other site 189918016027 activation loop (A-loop); other site 189918016028 activation loop (A-loop); other site 189918016029 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 189918016030 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 189918016031 active site 189918016032 NTP binding site [chemical binding]; other site 189918016033 metal binding triad [ion binding]; metal-binding site 189918016034 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 189918016035 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189918016036 Zn2+ binding site [ion binding]; other site 189918016037 Mg2+ binding site [ion binding]; other site 189918016038 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 189918016039 active site 189918016040 Ap6A binding site [chemical binding]; other site 189918016041 nudix motif; other site 189918016042 metal binding site [ion binding]; metal-binding site 189918016043 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 189918016044 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 189918016045 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 189918016046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189918016047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189918016048 DNA binding residues [nucleotide binding] 189918016049 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 189918016050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 189918016051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189918016052 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189918016053 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189918016054 catalytic residues [active] 189918016055 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 189918016056 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 189918016057 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 189918016058 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 189918016059 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 189918016060 active site 189918016061 metal binding site [ion binding]; metal-binding site